749,783 results match your criteria Future Oncology[Journal]


In Vitro Methods for Assessing Nanoparticle Toxicity.

Methods Mol Biol 2019 ;1894:1-29

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More

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January 2019

Functional Imaging of Visuospatial Attention in Complex and Naturalistic Conditions.

Curr Top Behav Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Lyon Neuroscience Research Center, Bron, France.

One of the ultimate goals of cognitive neuroscience is to understand how the brain works in the real world. Functional imaging with naturalistic stimuli provides us with the opportunity to study the brain in situations similar to the everyday life. This includes the processing of complex stimuli that can trigger many types of signals related both to the physical characteristics of the external input and to the internal knowledge that we have about natural objects and environments. Read More

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December 2018
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Statistical Network Inference for Time-Varying Molecular Data with Dynamic Bayesian Networks.

Methods Mol Biol 2019 ;1883:25-48

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

In this chapter, we review the problem of network inference from time-course data, focusing on a class of graphical models known as dynamic Bayesian networks (DBNs). We discuss the relationship of DBNs to models based on ordinary differential equations, and consider extensions to nonlinear time dynamics. We provide an introduction to time-varying DBN models, which allow for changes to the network structure and parameters over time. Read More

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January 2019

Laparoscopic transanal minimally invasive surgery (L-TAMIS) versus robotic TAMIS (R-TAMIS): short-term outcomes and costs of a comparative study.

Surg Endosc 2018 Dec 13. Epub 2018 Dec 13.

University of Tennessee Medical Center at Knoxville, 1934 Alcoa Highway, Bldg. D, Ste. 370, Knoxville, TN, 37920, USA.

Background: Transanal minimally invasive surgery (TAMIS) has gained worldwide popularity as a method for the local excision of rectal neoplasms. However, it is technically demanding due to limited working space. Robotic TAMIS offers potential enhanced dexterity and ability while allowing for a more aggressive resection with a stable platform. Read More

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December 2018

Understanding Patient Preferences and Unmet Needs in Non-alcoholic Steatohepatitis (NASH): Insights from a Qualitative Online Bulletin Board Study.

Adv Ther 2018 Dec 13. Epub 2018 Dec 13.

Novartis Healthcare Pvt Ltd, Hyderabad, India.

Introduction: The aim of this work was to understand how patients with non-alcoholic steatohepatitis (NASH) perceive their disease, unmet needs, and expectations regarding future treatment through online bulletin board (OBB) qualitative research.

Methods: OBB is an asynchronous online qualitative market research tool that provides an open forum for interactive discussion among participants. Patients with NASH were recruited via physician referral and completed a screener questionnaire to ensure their eligibility and willingness to participate. Read More

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December 2018

Learning how to exploit sources of information.

Mem Cognit 2018 Dec 13. Epub 2018 Dec 13.

Psychology Department, University of Haifa, Haifa, Israel.

How is our strategy for forming memories shaped by experience with a task? Previous work using surprise questions (i.e., unexpected by the participant) has shown a remarkable inability to report attributes of an attended target in a search display. Read More

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December 2018

Standardized Cost Estimates for Home Visiting: Pilot Study of the Home Visiting Budget Assistance Tool (HV-BAT).

Matern Child Health J 2018 Dec 13. Epub 2018 Dec 13.

Division of Home Visiting and Early Childhood Systems, HRSA, Maternal and Child Health Bureau, 5600 Fishers Lane, Rockville, MD, 20857, USA.

Purpose Using a standardized approach and metrics to estimate home visiting costs across multiple evidence-based models and regions could improve the consistency and accuracy of cost estimates, allow stakeholders to observe trends in cost allocation, analyze how home visiting costs vary, and develop future program budgets. Between October 2015 and December 2018, we developed and pilot-tested the Home Visiting Budget Assistance Tool (HV-BAT) to standardize the collection of home visiting program costs and analyze costs for local implementing agencies (LIAs). Methods We recruited LIAs that implemented at least one of nine evidence-based home visiting models in 15 states implementing the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Program. Read More

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December 2018

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

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December 2018

Enabling Conversations: African American Patients' Changing Perceptions of Kidney Transplantation.

J Racial Ethn Health Disparities 2018 Dec 13. Epub 2018 Dec 13.

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 462 Grider Street, Buffalo, NY, 14215, USA.

Background: Racial disparities in access to kidney transplantation (KTX) among African Americans (AAs) have been attributed in part to insufficient patient education. Interventions are needed to provide AAs with culturally sensitive, understandable information that increases their capacity to pursue KTX. Research about the factors that activated patients to pursue KTX is necessary to inform such interventions; however, few studies have yielded this type of information. Read More

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December 2018
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Disability trends in Canada: 2001-2014 population estimates and correlates.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Social Science Centre, University of Western Ontario, 1151 Richmond Street, London, ON, N6G 2V4, Canada.

Objectives: Disability is a major concern for the health of midlife and older Canadians. Understanding disability trends is critical for detecting socio-economic and health precursors that could be amenable to policy interventions. The purpose of this study is to assess trends in rates of disability among Canadian adults age 40-64 and 65+. Read More

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December 2018

Identification of potential genes involved in triterpenoid saponins biosynthesis in Gleditsia sinensis by transcriptome and metabolome analyses.

J Nat Med 2018 Dec 13. Epub 2018 Dec 13.

Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi, 980-8577, Japan.

Gleditsia sinensis is widely used as a medicinal plant in Asia, especially in China. Triterpenes, alkaloids, and sterols were isolated from Gleditsia species. Among them, triterpenoid saponins are very important metabolites owing to their various pharmacological activities. Read More

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December 2018

Cecal coccidiosis in turkeys: Comparative biology of Eimeria species in the lower intestinal tract of turkeys using genetically typed, single oocyst-derived lines.

Parasitol Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathobiology, University of Guelph, Guelph, Ontario, N1G2W1, Canada.

Differentiating the Eimeria species causing cecal coccidiosis in turkeys is challenging. To obtain benchmark biological data for Eimeria gallopavonis Hawkins 1952 and Eimeria meleagridis Tyzzer 1929 and to support the stability of the species concept for each, genetically typed, single oocyst-derived lines of E. gallopavonis Weybridge strain and E. Read More

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December 2018

Glaucoma - Next Generation Therapeutics: Impossible to Possible.

Pharm Res 2018 Dec 13;36(2):25. Epub 2018 Dec 13.

Ophthalmology Research, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts, 02139, USA.

The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administered as topical drops. Read More

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December 2018

SIU-ICUD consultation on bladder cancer: basic science.

World J Urol 2018 Dec 13. Epub 2018 Dec 13.

Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.

Purpose: To provide a condensed summary of the Basic Science chapter that was included in the Third International Consultation on Bladder Cancer.

Methods: World bladder cancer basic science experts used the published literature to create summaries of recent progress in their areas of expertise.

Results: The completion of several large-scale genomics projects coupled with a strong collaborative culture within the research community and the exciting clinical activity of immune checkpoint blockade have combined to transform the bladder cancer research landscape. Read More

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December 2018

Design of a 3D navigation template to guide the screw trajectory in spine: a step-by-step approach using Mimics and 3-Matic software.

J Spine Surg 2018 Sep;4(3):645-653

Department of Spine Surgery, Digital Orthopedic Institute, Orthopedic Hospital, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Surgery Center, Wenzhou 325027, China.

Rapid development of 3D printing techniques has led to the design of navigation templates to assist with accurate insertion of pedicle screws in last decades. However, there are still without the precise step-by-step methods to design 3D navigation templates from computed tomography (CT) images. Our present article provides a detailed protocol to allow the readers or researchers to obtain the 3D navigation template easily, and assist with pedicle screw insertion in their future research and surgery. Read More

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September 2018

Comparison of implant survivability in primary 1- to 2-level lumbar fusion amongst opioid abusers and non-opioid abusers.

J Spine Surg 2018 Sep;4(3):568-574

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Primary lumbar fusion (LF) is a treatment option for degenerative disc disease. The literature is limited regarding postoperative complications in opioid abusers undergoing LF. The purpose of this study was to compare 2-year short term implant-related complications, infection rates, 90-day readmission rates, in-hospital length of stay, and cost of care amongst opioid abusers (OAS) and non-opioid abusers (NAS) undergoing primary 1- to 2-level primary lumbar fusion (1-2LF). Read More

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September 2018

Perceived Benefits and Risks of Social Media: Ethiopian Secondary School Students' Perspectives.

J Technol Behav Sci 2018 19;3(4):294-300. Epub 2018 Jun 19.

Department of Psychology, Bahir Dar University, Bahir Dar, Ethiopia.

Recent findings show teenagers use social media increasingly in their daily life. There is also a consensus that social media have both pros and perils on students' academic affairs. The objective of this study is to assess how Ethiopian secondary school students perceive the benefits and risks associated with social media use. Read More

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Dataset on significant role of Candesartan on cognitive functions in rats having memory impairment induced by electromagnetic waves.

Data Brief 2018 Dec 26;21:2390-2394. Epub 2018 Nov 26.

Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) research group, Lebanese University, Faculty of Sciences (V), Nabatieh, Lebanon.

Rapid growing of mobile phones users has raised about the possible effects of these electromagnetic waves (EMW) on human health. Many studies have examined the role of these EMW on biological systems, but the results are still contradictory and controversial. In addition to EMW, over-activation of angiotensin type 1 receptor (AT1R) has been associated with cognitive decline, incidence and progression of neurodegenerative diseases. Read More

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December 2018

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.

Mol Ther Methods Clin Dev 2018 Dec 25;11:143-154. Epub 2018 Oct 25.

Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagenesis has resulted in the development of leukemia. We have utilized cellular bar coding to investigate the impact of different vector designs on the clonal behavior of hematopoietic stem and progenitor cells (HSPCs) during expansion, as a quantitative surrogate assay for genotoxicity in a non-human primate model with high relevance for human biology. Read More

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December 2018

Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.

Front Oncol 2018 28;8:563. Epub 2018 Nov 28.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Head and neck cancer is the 6th most common malignancy worldwide and urgently requires novel therapy methods to change the situation of low 5-years survival rate and poor prognosis. Targeted therapy provides more precision, higher efficiency while lower adverse effects than traditional treatments like surgery, radiotherapy, and chemotherapy. Blockade of PD-1 pathway with antibodies against PD-1 or PD-L1 is such a typical targeted therapy which reconstitutes anti-tumor activity of T cell in treatments of cancers, especially those highly expressing PD-L1, including head and neck cancers. Read More

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November 2018

Contribution of IL-33 to the Pathogenesis of Colorectal Cancer.

Front Oncol 2018 28;8:561. Epub 2018 Nov 28.

Department of Gastroenterology, University Hospital of North Norway, Tromsø, Norway.

The development of colorectal cancer (CRC) is not only determined by transformed cells , but also by factors existing in their immune microenvironment. Accumulating scientific evidence has revealed that interleukin (IL)-33, an IL-1 family member, plays an essential role in the regulation of immune response and is relevant in CRC pathogenesis. Data from both human and experimental studies demonstrated that IL-33 inhibits host anti-tumor immunity, remodels tumor stroma and enhances angiogenesis, thereby promoting the development of CRC. Read More

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November 2018

A Dual Mode Propulsion System for Small Satellite Applications.

Aerospace (Basel) 2018 2;5(2):52. Epub 2018 May 2.

Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405, USA;

This study focused on the development of a chemical micropropulsion system suitable for primary propulsion and/or attitude control for a nanosatellite. Due to the limitations and expense of current micropropulsion technologies, few nanosatellites with propulsion have been launched to date; however, the availability of such a propulsion system would allow for new nanosatellite mission concepts, such as deep space exploration, maneuvering in low gravity environments and formation flying. This work describes the design of "dual mode" monopropellant/bipropellant microthruster prototype that employs a novel homogeneous catalysis scheme. Read More

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3D biofabrication for tubular tissue engineering.

Biodes Manuf 2018 23;1(2):89-100. Epub 2018 May 23.

1Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE UK.

The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. Read More

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Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics.

J Pharm Investig 2018 28;48(1):43-60. Epub 2017 Nov 28.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyonggi-do 10326 Republic of Korea.

Nanomedicines have evolved into various forms including dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles since their first launch in the market. Widely highlighted benefits of nanomedicines over conventional medicines include superior efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profiles of pharmaceutical ingredients. Especially, various kinetic characteristics of nanomedicines in body are further influenced by their formulations. Read More

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November 2017

Healthy Life Centre participants' perceptions of living with overweight or obesity and seeking help for a perceived "wrong" lifestyle - a qualitative interview study.

BMC Obes 2018 6;5:42. Epub 2018 Dec 6.

1Faculty of Health and Social Sciences, Department of Health and Caring Science, Western Norway University of Applied Sciences, Bjørnsons gate 45, 5528 Haugesund, Norway.

Background: Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. Read More

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December 2018

Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):607-612. Epub 2018 Oct 5.

Department of Oncology, Hainan Branch of PLA General Hospital, Sanya, Hainan 572000, P.R. China.

Gastric adenocarcinoma concurrent with metastatic neuroendocrine cancer (NEC) is rare. In the present case report, a 39-year-old male was first pathologically diagnosed by gastric endoscopy as having a highly differentiated adenocarcinoma. Next, positron emission tomography-computed tomography examination and bone marrow biopsy confirmed extensive metastasis. Read More

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December 2018

Costs associated with management of non-communicable diseases in the Arab Region: a scoping review.

J Glob Health 2018 Dec;8(2):020410

Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.

Background: Global mortality rates resulting from non-communicable diseases (NCDs) are reaching alarming levels, especially in low- and middle-income countries, imposing a considerable burden on individuals and health systems as a whole. This scoping review aims at synthesizing the existing literature evaluating the cost associated with the management and treatment of major NCDs across all Arab countries; at evaluating the quality of these studies; and at identifying the gap in existing literature.

Methods: A systematic search was conducted using Medline electronic database to retrieve articles evaluating costs associated with management of NCDs in Arab countries, published in English between January 2000 and April 2016. Read More

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December 2018

Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma.

Oncotarget 2018 Nov 16;9(90):36126-36136. Epub 2018 Nov 16.

Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantation of breast prostheses. We performed comprehensive next generation sequencing based genomic characterization of 11 cases of BIA-ALCL including sequence variant detection on 180 genes frequently mutated in haematological malignancy, genome-wide copy number assessment, structural variant detection involving the T-cell receptor loci and TRB deep-sequencing. We observed sequence variants leading to JAK/STAT activation in 10 out of 11 patients. Read More

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November 2018

Giving Voice to Patients: Developing a Discussion Method to Involve Patients in Translational Research.

Nanoethics 2018 9;12(3):181-197. Epub 2018 Jul 9.

4Wageningen University and Research, Wageningen, The Netherlands.

Biomedical research policy in recent years has often tried to make such research more 'translational', aiming to facilitate the transfer of insights from research and development (R&D) to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. Read More

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Closing remarks: novel approaches to complex societal change and sustainability.

Sustain Sci 2018 29;13(6):1589-1596. Epub 2018 May 29.

1Arizona State University, Tempe, USA.

This paper summarizes some personal impressions of the 7th conference of the International Complex Systems Society, co-organized with "Future Earth", held in Stockholm on August 24-26, 2017. The main point is that it is urgent and important to consider the sustainability conundrum as long-term, society-driven one, and to place societal dynamics at the core of how we, as a global society, came to this point, how ongoing dynamics are driving us towards a tipping point, and which role the Information and Communication Technology revolution plays in that process. A much wider involvement of the social sciences is essential. Read More

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May 2018
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Urban tinkering.

Sustain Sci 2018 6;13(6):1549-1564. Epub 2018 Aug 6.

19University of the Witwatersrand, Johannesburg, South Africa.

Cities are currently experiencing serious, multifaceted impacts from global environmental change, especially climate change, and the degree to which they will need to cope with and adapt to such challenges will continue to increase. A complex systems approach inspired by evolutionary theory can inform strategies for policies and interventions to deal with growing urban vulnerabilities. Such an approach would guide the design of new (and redesign of existing) urban structures, while promoting innovative integration of grey, green and blue infrastructure in service of environmental and health objectives. Read More

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Framing natural assets for advancing sustainability research: translating different perspectives into actions.

Sustain Sci 2018 17;13(6):1519-1531. Epub 2018 Jul 17.

10Basque Centre for Climate Change, University of the Basque Country (UPV-EHU), Sede Building 1, 1st Floor, Scientific Campus, Leioa, 48940 Bilbao, Spain.

Sustainability is a key challenge for humanity in the context of complex and unprecedented global changes. Future Earth, an international research initiative aiming to advance global sustainability science, has recently launched knowledge-action networks (KANs) as mechanisms for delivering its research strategy. The research initiative is currently developing a KAN on "natural assets" to facilitate and enable action-oriented research and synthesis towards natural assets sustainability. Read More

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Mapping interactions between the sustainable development goals: lessons learned and ways forward.

Sustain Sci 2018 13;13(6):1489-1503. Epub 2018 Jul 13.

10CSIRO Land and Water, Canberra, Australia.

Pursuing integrated research and decision-making to advance action on the sustainable development goals (SDGs) fundamentally depends on understanding interactions between the SDGs, both negative ones ("trade-offs") and positive ones ("co-benefits"). This quest, triggered by the 2030 Agenda, has however pointed to a gap in current research and policy analysis regarding how to think systematically about interactions across the SDGs. This paper synthesizes experiences and insights from the application of a new conceptual framework for mapping and assessing SDG interactions using a defined typology and characterization approach. Read More

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July 2018
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Tracking of sport and exercise types from midlife to old age: a 20-year cohort study of British men.

Eur Rev Aging Phys Act 2018 7;15:16. Epub 2018 Dec 7.

1UCL Department of Primary Care & Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF UK.

Background: Previous physical activity (PA) tracking studies have examined the stability of overall PA and/or PA types, but few have investigated how specific types of sport/exercise track over the life course. The aim of this study was to determine how specific sports/exercises in midlife track and predict future sport/exercise and PA in men transitioning to old age.

Methods: Seven thousand seven hundred thirty-five men (aged 40-59 years) recruited in 1978-80 were followed up after 12, 16 and 20 years. Read More

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December 2018

Lenvatinib as a novel treatment for anaplastic thyroid cancer: A retrospective study.

Oncol Lett 2018 Dec 5;16(6):7271-7277. Epub 2018 Oct 5.

Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa 241-8515, Japan.

Anaplastic thyroid cancer (ATC) is associated with an extremely poor prognosis and is resistant to the majority of chemotherapies. In 2015, lenvatinib was approved for treating ATC in Japan. The present study aimed to evaluate the overall survival (OS) of patients with ATC treated with lenvatinib. Read More

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December 2018

Methylation of and together with HPV status in cytological cervical specimens serves an important role in the progression of cervical intraepithelial neoplasia.

Oncol Lett 2018 Dec 26;16(6):7166-7174. Epub 2018 Sep 26.

Department of Obstetrics and Gynecology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, SK-03601 Martin, Slovakia.

Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Read More

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December 2018

Correlation between coronary atherosclerosis calcification and epicardial adipose tissue volume in patients with nephropathy.

Exp Ther Med 2018 Dec 27;16(6):4669-4673. Epub 2018 Sep 27.

Department of Cardiovascular Medicine, The Central Hospital of Tongchuan Mining Bureau, Tongchuan, Shaanxi 727000, P.R. China.

Correlation between coronary atherosclerosis calcification and epicardial adipose tissue (EAT) volume in patients with nephropathy was investigated. A total of 529 patients with high risk of coronary atherosclerotic nephropathy were selected from August 2013 to September 2016 in Xianyang Central Hospital to serve as research subjects, and their clinical data were retrospectively analyzed. All patients underwent coronary artery and EAT examination using dual-source CT. Read More

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December 2018

Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

Future Virol 2018 Mar 21;13(3):143-146. Epub 2018 Feb 21.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant and a Model C Photosynthesis Plant .

Front Plant Sci 2018 28;9:1757. Epub 2018 Nov 28.

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.

Crassulacean acid metabolism (CAM) improves photosynthetic efficiency under limited water availability relative to C photosynthesis. It is widely accepted that CAM plants have evolved from C plants and it is hypothesized that CAM is under the control of the internal circadian clock. However, the role that the circadian clock plays in the evolution of CAM is not well understood. Read More

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November 2018

Involvement of Human Papillomaviruses in Cervical Cancer.

Front Microbiol 2018 28;9:2896. Epub 2018 Nov 28.

Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan, China.

Human papillomaviruses (HPV) are the first viruses to have been acknowledged to prompt carcinogenesis, and they are linked with cancers of the uterine cervix, anogenital tumors, and head and neck malignancies. This paper examines the structure and primary genomic attributes of HPV and highlights the clinical participation of the primary HPV serotypes, focusing on the roles that HPV-16 and 18 play in carcinogenesis. The mechanisms that take place in the progression of cervical neoplasia are described. Read More

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November 2018

Bone Marrow Fat and Hematopoiesis.

Front Endocrinol (Lausanne) 2018 28;9:694. Epub 2018 Nov 28.

Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.

Bone marrow fat cells comprise the largest population of cells in the bone marrow cavity, a characteristic that has attracted the attention of scholars from different disciplines. The perception that bone marrow adipocytes are "inert space fillers" has been broken, and currently, bone marrow fat is unanimously considered to be the third largest fat depot, after subcutaneous fat and visceral fat. Bone marrow fat (BMF) acts as a metabolically active organ and plays an active role in energy storage, endocrine function, bone metabolism, and the bone metastasis of tumors. Read More

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November 2018

Work and Organizational Psychology Looks at the Fourth Industrial Revolution: How to Support Workers and Organizations?

Front Psychol 2018 28;9:2365. Epub 2018 Nov 28.

Department of Psychology, University of Turin, Turin, Italy.

With rapid advances in technology in several fields of human life, we are entering the Fourth Industrial Revolution (FIR), which is changing the way businesses create value, people do their work and individuals interact and communicate with each other. In this framework, many questions have arisen about how these transformations affect workers, organizations and societies, and Work and Organizational Psychology (WOP) has been called upon to address some of these open issues. In particular, this article focuses on two aspects of the FIR. Read More

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November 2018

Comparing Effects of Reward Anticipation on Working Memory in Younger and Older Adults.

Front Psychol 2018 28;9:2318. Epub 2018 Nov 28.

Chair of Lifespan Developmental Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany.

Goal-directed behavior requires sufficient resource allocation of cognitive control processes, such as the ability to prioritize relevant over less relevant information in working memory. Findings from neural recordings in animals and human multimodal imaging studies suggest that reward incentive mechanisms could facilitate the encoding and updating of context representations, which can have beneficial effects on working memory performance in young adults. In order to investigate whether these performance enhancing effects of reward on working memory processes are still preserved in old age, the current study aimed to investigate whether aging alters the effects of reward anticipation on the encoding and updating mechanisms in working memory processing. Read More

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November 2018
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Pupillary Measures of the Cognitive Effort in Auditory Novel Word Processing and Short-Term Retention.

Front Psychol 2018 27;9:2248. Epub 2018 Nov 27.

Department of Psychology, Universidad Complutense de Madrid, Madrid, Spain.

The use of the task-evoked pupillary responses (TEPRs) methodology is emerging in the psycholinguistics literature, as a sensitive, reliable and dynamic psychophysiological measure of the cognitive effort produced by various aspects of language processing. This preliminary study aimed to assess the functionality and effectiveness of a TEPRs design for measuring the cognitive effort required for the processing and spontaneous (non-explicitly prompted) short-term retention of novel phonological forms presented auditorily. Twenty-four young adult participants (aged 19-28 years, = 20. Read More

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November 2018
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The Connected Community Pharmacy: Benefits for Healthcare and Implications for Health Policy.

Front Pharmacol 2018 28;9:1352. Epub 2018 Nov 28.

SGS PharmaSolutions, Gloucestershire, United Kingdom.

The need for interoperability of healthcare Information Technology (IT) systems in order to provide safe, efficient, and coordinated healthcare is universally recognized. Various health economies, such as the United Kingdom, the United States, and Australia, are seeking to develop regional, state-wide, or national systems of healthcare interoperability. In England, the community pharmacy network is a significant health provider, with important implications for provision of healthcare in deprived areas because of its accessibility. Read More

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November 2018
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Validation of a Multiplexed Opsonophagocytic Assay for 11 Additional Pneumococcal Serotypes and Its Application to Functional Antibody Evaluation Induced by Pneumococcal Polysaccharide Vaccine.

J Korean Med Sci 2018 Dec 12;33(51):e340. Epub 2018 Dec 12.

Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea.

Background: Various pneumococcal vaccines have been evaluated for immunogenicity by opsonophagocytic assay (OPA). A multiplexed OPA (MOPA) for 13 pneumococcal serotypes was developed by Nahm and Burton, and expanded to 26 serotypes in 2012. The development of new conjugate vaccines with increased valence has necessitated expanded MOPAs to include these additional serotypes. Read More

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December 2018

Estimating PM speciation concentrations using prototype 4.4 km-resolution MISR aerosol properties over Southern California.

Atmos Environ (1994) 2018 May 10;181:70-81. Epub 2018 Mar 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.

Research efforts to better characterize the differential toxicity of PM (particles with aerodynamic diameters less than or equal to 2.5 μm) speciation are often hindered by the sparse or non-existent coverage of ground monitors. The Multi-angle Imaging SpectroRadiometer (MISR) aboard NASA's Terra satellite is one of few satellite aerosol sensors providing information of aerosol shape, size and extinction globally for a long and continuous period that can be used to estimate PM speciation concentrations since year 2000. Read More

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The Effects of Natural Daylight on Length of Hospital Stay.

Environ Health Insights 2018 3;12:1178630218812817. Epub 2018 Dec 3.

Department of Psychiatry, School of Medicine, Ajou University, Suwon, Korea.

Background And Purpose: While providing medical services, hospitals generate many data about patients. Such medical data could contribute to better treatments once their associations or patterns have been identified. With properly analyzed medical data, traditional knowledge at an individual level could be further extended to broader populations. Read More

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December 2018

Peripheral Biomarker for Vascular Disorders.

Biomark Insights 2018 29;13:1177271918812467. Epub 2018 Nov 29.

School of Life Sciences and Centre for Health Technologies, University of Technology Sydney, Broadway, NSW, Australia.

Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall. It is known that increased intima media thickness (IMT) is a non-invasive marker of arterial wall alteration, which can easily be assessed in the carotid arteries by high-resolution B-mode ultrasound. Read More

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November 2018
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