748,404 results match your criteria Future Neurology[Journal]
Aktuelle Urol 2018 Dec 6;49(6):509-514. Epub 2018 Dec 6.
Universitätsklinikum Köln, Klinik für Urologie, Uro-Onkologie, spezielle urologische und roboter-assistierte Chirurgie, Köln.
Due to demographic changes and aging in the German population combined with the shortage of doctors, new techniques are needed to ensure urological patient care in the future. Telemedicine offers great potential to facilitate patient monitoring in their familiar surroundings and to ameliorate patient's compliance with the suggested therapy concept. Through optimal and reliable transfer of patient data, telemedicine helps to optimise patient satisfaction with urological therapies, binds them to their doctor and raises diagnostic safety. Read More
Aktuelle Urol 2018 Dec 6;49(6):500-508. Epub 2018 Dec 6.
Klinik und Poliklinik für Urologie und Kinderurologie der Universitätsmedizin Mainz, Mainz.
Introduction: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have partially been implemented in clinical daily routine. Read More
Aktuelle Urol 2018 Dec 6;49(6):488-499. Epub 2018 Dec 6.
Urologische Universitätsklinik Mannheim, Klinik für Urologie und Kinderurologie, Mannheim.
The introduction of robotics led to a decrease in the importance of classical laparoscopy. Nevertheless laparoscopy and retroperitoneoscopy underwent significant technological improvements during the last decade, including introduction of 4k Ultra HD video technology, 3D-HD-videosystems, minaturised instruments, advanced sealing devices, instruments with 7 degrees of freedom, and ergonomic platforms Ethos Chair. The monopoly of robotic surgical devices will end in 2019, because key patents of Intuitive Surgical will expire. Read More
Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland.
The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of Sodium Glucose Co-Transporter-2 Inhibition on the ARR in patients with type 2 diabetes mellitus (T2DM) who were prescribed a Sodium Glucose Co-Transporter-2 Inhibitor (SGLT-2i) as part of routine clinical care. Read More
Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.
Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.
Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More
Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.
Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.
Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More
J Environ Manage 2018 Dec 3;232:654-659. Epub 2018 Dec 3.
ECT-School of Science and Technology, University of Trás-os-Montes e Alto Douro UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal; Centre for Transdisciplinary Development Studies, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal.
Impervious cover has important hydrologic impacts, namely the increased runoff volume and peak discharges in the rainwater network, which can lead to significant consequences like rapid urban floods with social, environmental and economic implications. LID (Low Impact Development) consist of distributed runoff management measures, like green roofs, pervious pavements, waterways covered with vegetation and filter trails, among others, that seek to control stormwater in the origin, reducing imperviousness. These solutions avoid increased runoff rate and volume, increase infiltration and groundwater recharge. Read More
J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.
Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.
Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More
J Environ Manage 2018 Dec 3;232:607-614. Epub 2018 Dec 3.
Departamento de Biociências, Universidade Federal Rural do Semiárido, Av. Francisco Mota, 572, Mossoró, Rio Grande do Norte, Brazil. Electronic address:
Protected areas are an important strategy to safeguard biodiversity. However, if social development is not considered, biological conservation targets may not be achieved. In this empirical study, we assess the relationship between poverty and conservation goals in dry forests within a 62,000-ha Brazilian National Park (Caatinga biome). Read More
Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.
Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:
Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More
Drug Alcohol Depend 2018 Dec 3;194:482-486. Epub 2018 Dec 3.
Department of Academic Affairs, Baystate Medical Center, 3601 Main St., Springfield, MA 01199, United States. Electronic address:
Background: Criminal justice involved (CJS) populations with opioid use disorder (OUD) have high rates of relapse, future arrests, and death upon release. While medication for OUD (MOUD) reduces opioid relapse, concerns regarding diversion and stigma limit treatment in CJS populations. Extended release naltrexone (XR-NTX), as an opioid antagonist, may be more acceptable to CJS administrators. Read More
Arch Oral Biol 2018 Nov 28;98:238-242. Epub 2018 Nov 28.
Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan. Electronic address:
Objective: The aim of the present study was to investigate whether anterior tongue muscle strengthening exercises can affect the strength of posterior tongue muscles.
Design: Eleven healthy subjects (20.6 ± 1. Read More
Sci Total Environ 2018 Nov 22;656:482-494. Epub 2018 Nov 22.
Nelson Mandela University, PO Box 77000, Port Elizabeth 6031, South Africa. Electronic address:
This paper presents an environmental flow methodology that was developed to accommodate shallow, highly dynamic micro-tidal estuaries found along the wave-dominated coast of South Arica. This method differs to most other approaches that primarily focus on larger permanently open systems having unrestricted inlets. Following an adaptive, design science research approach, the 7-step method adopted both ecohydrological and ecosystem-based concepts, encapsulating key hydrologicalhydrodynamic-biogeochemical processes, as well as biotic responses. Read More
Biomed Pharmacother 2018 Dec 3;110:312-318. Epub 2018 Dec 3.
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically been notable worldwide and many attempts have been made to raise the overall survival of CRC patients. Immune response has long been a question of great interest in a wide range of fields such as cancer therapies and anti-tumor immunity through checkpoint inhibitors, specifically anti PD-1/ PD-L1 interaction, is a new line of research for treatment of CRC patients. Following the successful development of anti-PD-1 for melanoma, renal cell carcinoma, and non-small cell lung cancer, several clinical trials have been conducted on monoclonal antibodies (MAbs) against PD-1 in CRC. Read More
Psychoneuroendocrinology 2018 Nov 30;102:63-67. Epub 2018 Nov 30.
Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, D-54290, Trier, Germany. Electronic address:
Secretion of the stress hormone cortisol follows a circadian rhythm and is stimulated following stress exposure. Cortisol regulates the transcription of several genes, primarily through activation of the glucocorticoid receptor (GR). Previously, we showed an upregulation of PERIOD genes PER1 and PER3 after pharmacological/glucocorticoid challenge in vivo and in vitro. Read More
Curr Opin Psychol 2018 Nov 22;28:76-80. Epub 2018 Nov 22.
Faculty of Health Sciences, Universitat Oberta de Catalunya, Av. Tibidabo, 39-43, 08035, Barcelona, Spain; Honorary Fellow, Center for Healthy Minds, University of Wisconsin-Madison, United States. Electronic address:
In the last decade, epigenetics has taken center stage to explain the relationships between stress exposure, health and behavior. Acquired or inherited epigenetic changes modulate gene expression states without modifying the DNA sequence itself, they can be long-lasting, yet, they are potentially reversible. Several studies have explored whether meditation-based interventions can influence gene expression profiles towards healthier directions, identifying candidate genes and biological pathways that seem to be sensitive to contemplative practices. Read More
Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 19;211:94-99. Epub 2018 Nov 19.
Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Science Campus, Alagappa University, Karaikudi 630003, India. Electronic address:
In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. Read More
Adv Colloid Interface Sci 2018 Nov 24;263:68-94. Epub 2018 Nov 24.
Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, 1065 Avenue de la médecine, Québec G1V 0A6, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hôpital St-François d'Assise, 10 rue de l'Espinay, Québec G1L 3L5, Canada. Electronic address:
Glass- and polymer-based materials have become essential in the fabrication of a multitude of elements, including eyeglasses, automobile windshields, bathroom mirrors, greenhouses, and food packages, which unfortunately mist up under typical operating conditions. Far from being an innocuous phenomenon, the formation of minute water drops on the surface is detrimental to their optical properties (e.g. Read More
J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.
CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:
Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More
Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.
Native Medicine and Marine Pharmacology Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Chennai 603 103, Tamil Nadu, India. Electronic address:
A low molecular weight posterior salivary gland (PSG) toxin was isolated and purified from the cuttlefish Sepia prashadi by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). The protein and neutral sugar content of the PSG toxin was determined to be 1.033 mg/g and 282 μg/g. Read More
Biosystems 2018 Dec 3. Epub 2018 Dec 3.
School of Life Sciences, College of Agriculture, Engineering and Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
Schistosomiasis, the most common water-borne infection worldwide, continues to pose a serious public health challenge in developing nations and to travellers who visit these endemic regions. We apply optimal control on a temperature dependent schistosomiasis model. Our optimal control aims to minimize the pre-patent and patent human population at minimal costs. Read More
J Biomed Inform 2018 Dec 3. Epub 2018 Dec 3.
Institute of Informatics, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:
Microarrays are still one of the major techniques employed to study cancer biology. However, the identification of expression patterns from microarray datasets is still a significant challenge to overcome. In this work, a new approach using Neuroevolution, a machine learning field that combines neural networks and evolutionary computation, provides aid in this challenge by simultaneously classifying microarray data and selecting the subset of more relevant genes. Read More
Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.
Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:
Single enzyme systems or engineered microbial hosts have been used for decades but the notion of assembling multiple enzymes into cell-free synthetic pathways is a relatively new development. The extensive possibilities that stem from this synthetic concept makes it a fast growing and potentially high impact field for biomanufacturing fine and platform chemicals, pharmaceuticals and biofuels. However, the translation of individual single enzymatic reactions into cell-free multi-enzyme pathways is not trivial. Read More
Microb Pathog 2018 Dec 3. Epub 2018 Dec 3.
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Staphylococcus aureus is a human commensal and pathogen, its clinical importance is exacerbated by the spread of multi-drug resistant strains. The potential future failure of antibiotic therapy necessitates the development of novel control regimes, including new immunotherapeutic approaches. S. Read More
Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Arboviruses represent a group of pathogens that can spread efficiently throughout human populations by hematophagous arthropod vectors. The mosquito-borne (re)emerging Chikungunya and Dengue viruses belong to the alphavirus and flavivirus genus, respectively, with no approved therapeutics or safe vaccines for humans. Transmitted by the same vector Aedes spp. Read More
Antiviral Res 2018 Dec 3. Epub 2018 Dec 3.
Institute for Antiviral Research, Utah State University, Logan, UT, United States; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, United States; Utah Veterinary Diagnostic Laboratory, Logan, UT, United States. Electronic address:
Enterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used for evaluation of experimental therapeutics. Read More
Exp Parasitol 2018 Dec 3. Epub 2018 Dec 3.
Laboratory of Molecular and Evolutionary Parasitology, RAPID Group, School of Biosciences, University of Kent, Canterbury, Kent, UK; School of Biosciences, University of Kent, Canterbury, Kent, UK. Electronic address:
Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis. Read More
Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.
Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:
Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More
FASEB J 2018 Dec 6:fj201801463R. Epub 2018 Dec 6.
Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC) Unité Mixte de Recherche (UMR) 7178, Université de Strasbourg, Strasbourg, France.
Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut's health and safety. However, consequences on B-cell development and responses are still under-investigated. To fill this gap, we used advanced proteomics analysis of femur bone and marrow to compare mice flown for 1 mo on board the BION-M1 biosatellite, followed or not by 1 wk of recovery on Earth, to control mice kept on Earth. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD013188. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More
Cochrane Database Syst Rev 2018 Dec 3;12:CD011902. Epub 2018 Dec 3.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.
Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion by a clinician are usually the first in a series of 'tests' to diagnose skin cancer, dermoscopy has become an important tool to assist diagnosis by specialist clinicians and is increasingly used in primary care settings. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5773-5784
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels and retinal ganglion cell axons during early eye development. Failure to close the OF is the developmental basis for uveal coloboma, a congenital blinding eye disease that significantly contributes to childhood blindness. Genes specifically expressed in the OF region may play important roles in OF development and function. Read More
Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.
Purpose: The purpose of this study was to evaluate a new graft material, biphasic calcium phosphate, composed of 60% hydroxyapatite and 40% β-Tricalcium phosphate and deproteinized bovine bone mineral, which is established as a predictable graft material for maxillary sinus augmentation.
Materials And Methods: Maxillary sinus augmentation was performed with different bone materials. Bone biopsies were performed on tissue harvested from the future implant bed using a trephine bur at 6 months after maxillary sinus augmentation. Read More
Acta Biochim Pol 2018 Dec 6. Epub 2018 Dec 6.
Uniwersytet Gdański Wydział Chemii Katedra Biotechnologii Molekularnej ul. Wita Stwosza 63 80-308 Gdańsk.
Supplementing the human microbiome with probiotic microorganisms is a proposed solution for civilization syndromes such as dysbiosis and gastrointestinal tract (GIT) disorders. Bimodal probiotic strains of the Bacillus genus constitute the microbiota of the human environment, and are typically found in soil, water, a number of non-dairy fermented foods, as well as in human and animal GIT. Probiotic Bacillus sp. Read More
PLoS One 2018 6;13(12):e0208575. Epub 2018 Dec 6.
School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Background: A key mechanism thought to underlie Posttraumatic Stress Disorder (PTSD) is enhanced emotional memory consolidation. Recent evidence in healthy controls revealed that women have greater negative memory consolidation following stress relative to men. This study examined emotional memory consolidation in women and men with PTSD, and in trauma-exposed and non-trauma controls to test the hypothesis that emotionally negative memory consolidation would be greater in women with PTSD. Read More
PLoS One 2018 6;13(12):e0208473. Epub 2018 Dec 6.
Department of Psychology, School of Sociology and Psychology, Central University of Finance and Economics, Beijing, China.
We were interested in how specific cultural value and adolescent social behavior would influence each other over time. Thus the present study explored the longitudinal and bidirectional relations between adolescents' power distance value and prosocial behavior toward powerful people over a year. A sample of 434 Chinese adolescents participated in the investigation (initial mean age = 11. Read More
PLoS One 2018 6;13(12):e0208585. Epub 2018 Dec 6.
UAB, Centre de Recerca en Sanitat Animal (CRESA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain.
Porcine circovirus 2 (PCV-2) is one of the most widespread viral infections of swine, causing a remarkable economic impact because of direct losses and indirect costs for its control. As other ssDNA viruses, PCV-2 is characterized by a high evolutionary rate, leading to the emergence of a plethora of variants with different biological and epidemiological features. Over time, several attempts have been made to organize PCV-2 genetic heterogeneity in recognized genotypes. Read More
PLoS One 2018 6;13(12):e0208402. Epub 2018 Dec 6.
Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
Background: Malaysia has a comprehensive, publicly-funded immunization program for hepatitis B (HepB) among infants, but adults must pay for the vaccine. The number of HepB carriers among adults is expected to increase in the future; therefore, we examined the impact of five constructs (cues to action, perceived barriers, perceived benefit, perceived severity, and perceived susceptibility) on adults' willingness to pay (WTP) for HepB vaccine; secondarily, we examined the association between perceived barriers and perceived benefits.
Methods: Adults were selected through a stratified, two-stage cluster community sample in Selangor, Malaysia. Read More
PLoS One 2018 6;13(12):e0208203. Epub 2018 Dec 6.
IBM Research Australia, Southgate, Victoria, Australia.
Background: Dengue is the fastest spreading vector-borne viral disease, resulting in an estimated 390 million infections annually. Precise prediction of many attributes related to dengue is still a challenge due to the complex dynamics of the disease. Important attributes to predict include: the risk of and risk factors for an infection; infection severity; and the timing and magnitude of outbreaks. Read More
PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.
Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.
Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More
PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.
Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.
Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More
PLoS One 2018 6;13(12):e0207200. Epub 2018 Dec 6.
GREPAQ (Groupe de recherche en pharmacologie animale du Québec), Department of biomedical sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
This study aimed to characterize bone cancer pain (quantitative sensory testing (QST), stance asymmetry index, actimetry, scores of pain and quality of life (QoL)) in dogs with appendicular osteosarcoma (OSA), and to evaluate a stepwise palliative analgesic treatment. The pain profile of thirteen client-owned dogs with OSA was compared with seven healthy dogs. Dogs with OSA were then enrolled in a prospective, open-label, clinical trial. Read More
PLoS One 2018 6;13(12):e0202622. Epub 2018 Dec 6.
Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Men who have sex with men (MSM) is the major risk population of HIV-1 infection in Taiwan, and its surveillance has become critical in HIV-1 prevention. We recruited MSM subjects from 17 high-risk venues and 4 community centers in northern and southern Taiwan for anonymous HIV-1 screening during 2013-2015. Blood samples were obtained for genotyping and phylogenetic analysis, and a questionnaire survey covering demographic variables and social behavior was conducted. Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006803. Epub 2018 Dec 6.
Zeeman Institute, University of Warwick, Coventry, United Kingdom.
Background: Age patterns in asymptomatic and symptomatic infection with Leishmania donovani, the causative agent of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), are currently poorly understood. Age-stratified serology and infection incidence have been used to assess transmission levels of other diseases, which suggests that they may also be of use for monitoring and targeting control programmes to achieve elimination of VL and should be included in VL transmission dynamic models. We therefore analysed available age-stratified data on both disease incidence and prevalence of immune markers with the aim of collating the currently available data, estimating rates of infection, and informing modelling and future data collection. Read More
PLoS Comput Biol 2018 Dec 6;14(12):e1006606. Epub 2018 Dec 6.
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.
In this paper, we present a novel Bayesian adaptive dual controller (ADC) for autonomously programming deep brain stimulation devices. We evaluated the Bayesian ADC's performance in the context of reducing beta power in a computational model of Parkinson's disease, in which it was tasked with finding the set of stimulation parameters which optimally reduced beta power as fast as possible. Here, the Bayesian ADC has dual goals: (a) to minimize beta power by exploiting the best parameters found so far, and (b) to explore the space to find better parameters, thus allowing for better control in the future. Read More
J Assoc Genet Technol 2018 ;44(4):141-145
Allina Health, Minneapolis, MN.
Objectives: Double-hit lymphomas represent 5% of cases of diffuse large B-cell lymphomas (DLBCL). They are currently recognized as highgrade B-cell lymphomas (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6 by the 2016 WHO classification. One of these rearrangements is the translocation of the BCL2 gene (18q21. Read More