750,360 results match your criteria Future Cardiology[Journal]


A Farewell to Falsity: Shifting Standards in Medicare Fraud Enforcement.

Authors:
Isaac D Buck

Seton Hall Law Rev 2019 ;49(1):1-51

University of Tennessee College of Law.

For the better part of a decade, Americans have had a front-row seat to a fervent and turbulent debate over the future of their health care system. The passage of the Patient Protection and Affordable Care Act of 2010 (ACA), the most comprehensive health reform effort since the mid-1960s, ushered in a new era in health law and policy, granting millions of Americans access to health care. After multiple legal challenges and congressional efforts that ultimately failed to slay the law, the ACA had become entrenched by the end of the Obama administration, even though pieces of the law had failed to work exactly as planned. Read More

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January 2019

Validation of a Rapid Microwave-Assisted Extraction Method and GC-FID Quantification of Total Branched Chain Fatty Acids in Lamb Subcutaneous Adipose Tissue.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

School of Agriculture and Food Science, Univ. College Dublin, Belfield, Dublin, 4, Ireland.

A rapid microwave-assisted extraction and derivatization of three branched chain fatty acids (BCFA): 4-methyloctanoic acid (MOA), 4-ethyloctanoic acid (EOA) and 4-methylnonanoic acid (MNA) from subcutaneous adipose tissue (SAT) of lamb was developed and validated. Linearity was excellent (R > 0.99), and the limits of detection and quantification (μg/mL) were between 0. Read More

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December 2018

Peak Oxygen Uptake in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Meta-Analysis.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

School of Health and Social Care, Teesside University, Middlesbrough, United Kingdom of Great Britain and Northern Ireland.

To evaluate the magnitude of the difference in VO between patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) and apparently healthy controls, 7 databases (Cochrane, PubMed, PsycINFO, Web of Knowledge, Embase, Scopus, Medline) were searched for articles published up to March 2018. Search terms included "chronic fatigue syndrom*"AND ("peak" OR "maxim*" OR "max") AND ("oxygen uptake" OR "oxygen consumption" OR "VO2peak" or "VO2max". Eligibility criteria were adults>18 y with clinically diagnosed CFS/ME, with VO measured in a maximal test and compared against an apparently healthy control group. Read More

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December 2018

Influence of edge magnetization and electric fields on zigzag silicene, germanene and stanene nanoribbons.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Department of Applied Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Nagoya, JAPAN.

Using a multi-orbital tight-binding model, we have studied the edge states of zigzag silicene, germanene, and stanene nanoribbons (ZSiNRs, ZGeNRs and ZSnNRs, respectively) in the presence of the Coulomb interaction and a vertical electric field. The resulting edge states have non-linear energy dispersions due to multi-orbital effects, and the nanoribbons show induced magnetization at the edges. Owing to this non-linear dispersion, ZSiNRs, ZGeNRs and ZSnNRs may not provide superior performance in field effect transistors, as has been proposed from single-orbital tight-binding model calculations. Read More

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December 2018

Exploration of high-pressure structural transition and electronic properties of BaFe2S3.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Qinghai University, Xining, Qinghai, CHINA.

The iron-based compound BaFe<sub>2</sub>S<sub>3</sub> has received considerable attention in recent years due to their unique electronic properties with important applications. But, there has been relatively little attention devoted to the structure evolution of BaFe<sub>2</sub>S<sub>3</sub> under high pressure. Here, we report a detailed theoretical study of the structural, electronic and sound velocity properties of BaFe<sub>2</sub>S<sub>3</sub> under high pressure by CALYPSO structure search method in combination with the first-principles calculations. Read More

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December 2018

Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Endocr Relat Cancer 2019 Feb;26(2):251-264

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Read More

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February 2019

O pollution in a future climate increases the competition between summer rape and wild mustard.

Plant Physiol Biochem 2018 Dec 11;135:194-205. Epub 2018 Dec 11.

Vytautas Magnus University, Department of Environmental Sciences, Vileikos St. 8-223, LT-44404, Kaunas, Lithuania.

The initial aim of this study was to evaluate an effect of elevated CO concentration and air temperature (future climate) and O pollution on mono- and mixed-culture grown summer rape (Brassica napus L.) and wild mustard (Sinapis arvensis L.). Read More

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December 2018

The development of anticipatory action planning in children with unilateral cerebral palsy.

Res Dev Disabil 2018 Dec 14;85:163-171. Epub 2018 Dec 14.

Department of Paediatrics, Monash University, Clayton, Victoria, 3168, Australia; School of Occupational Therapy, La Trobe University, Bundoora, Victoria, 3168, Australia; Victorian Paediatric Rehabilitation Service, Monash Children's Hospital, 246 Clayton Rd, Clayton, Victoria, 3168, Australia. Electronic address:

Background Previous studies suggest that compromised bimanual performance experienced by children with unilateral cerebral palsy (CP) is not only due to difficulties in action execution but may also be a result of impaired anticipatory action planning. Aims The effect of age and side of hemiplegia were examined and the relationship between anticipatory action planning, unimanual capacity and bimanual performance was explored. Methods and procedures Using a multi-centre, prospective, cross-sectional observational design, anticipatory action planning was analyzed in 104 children with unilateral cerebral palsy, aged 6-12 years, using the sword task. Read More

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December 2018
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MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.

Biomed Pharmacother 2018 Dec 14;110:850-856. Epub 2018 Dec 14.

Department of Gynaecology and Obstetrics, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China. Electronic address:

MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. Read More

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December 2018

Identification of novel PI3Kδ inhibitors by docking, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Dec 7;78:190-204. Epub 2018 Dec 7.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address:

Background: Phosphoinositide-3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ is confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Virtual screening techniques have been used to discover new molecules for developing novel PI3Kδ inhibitors with little side effects.

Method: Computer aided drug design method were used to rapidly screen optimal PI3Kδ inhibitors from the Asinex database. Read More

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December 2018

Brain activity in struggling readers before intervention relates to future reading gains.

Cortex 2018 Nov 16;111:286-302. Epub 2018 Nov 16.

Department of Psychology, The University of Texas at Austin, Austin, TX, USA; Biomedical Imaging Center, The University of Texas at Austin, Austin, TX, USA.

Neural markers for reading-related changes in response to intervention could inform intervention plans by serving as a potential index of the malleability of the reading network in struggling readers. Of particular interest is the role of brain activation outside the reading network, especially in executive control networks important for reading comprehension. However, it is unclear whether any intervention-related executive control changes in the brain are specific to reading tasks or reflect more domain general changes. Read More

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November 2018

Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.

Environ Int 2018 Dec 14;123:318-324. Epub 2018 Dec 14.

Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Background: Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited.

Objective: To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Read More

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December 2018

Assessment of forest fire impacts on carbonaceous aerosols using complementary molecular marker receptor models at two urban locations in California's San Joaquin Valley.

Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.

Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:

Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More

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December 2018

Variation in PFAA concentrations and egg parameters throughout the egg-laying sequence in a free-living songbird (the great tit, Parus major): Implications for biomonitoring studies.

Environ Pollut 2018 Dec 7;246:237-248. Epub 2018 Dec 7.

Behavioural Ecology and Ecophysiology Group, Department of Biology, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address:

Over the past decades, there has been growing scientific attention and public concern towards perfluoroalkyl acids (PFAAs), due to their widespread presence in the environment and associations with adverse effects on various organisms. Bird eggs have often been used as less-invasive biomonitoring tools for toxicological risk assessments of persistent organic pollutants, including some PFAAs. Hereby, it is typically assumed that one random egg is representative for the PFAA concentrations of the whole clutch. Read More

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December 2018

Association of quality of life with disease characteristics and treatment outcomes in patients with advanced gastric cancer: Exploratory analysis of RAINBOW and REGARD phase III trials.

Eur J Cancer 2018 Dec 14;107:115-123. Epub 2018 Dec 14.

Institute of Clinical Cancer Research (IKF), University Cancer Center, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. Electronic address:

Background: Inadequate understanding of interpretation of quality of life (QoL) instruments leads to unsatisfactory data reporting and clinical decision-making, including in gastric cancer care.

Materials And Methods: Pooled QoL data from two phase III studies of ramucirumab with or without paclitaxel in previously treated patients with gastric or gastroesophageal junction cancer were used to explore associations with clinical attributes, including tumour response, disease measurability and performance status (PS). The European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire (QLQ)-C30 was used in both studies. Read More

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December 2018

Social housing protects against age-related working memory decline independently of physical enrichment in rats.

Neurobiol Aging 2018 Nov 23;75:117-125. Epub 2018 Nov 23.

Psychology Department, Providence College, Providence, RI, USA.

Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for physical enrichment in all groups. Read More

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November 2018

Contingent biofeedback outperforms other methods to enhance the accuracy of cardiac interoception: A comparison of short interventions.

J Behav Ther Exp Psychiatry 2018 Dec 4;63:12-20. Epub 2018 Dec 4.

Institute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany. Electronic address:

Background And Objectives: Deviations in interoception might contribute to the development and maintenance of mental disorders. The improvement of interoceptive accuracy (IA) is desirable but assessment and training methods remain controversial. For instance, it was assumed that performance increases in heartbeat counting paradigms after cardiac feedback were due to an improvement of knowledge with regard to heart rate rather than due to an actual improvement in IA. Read More

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December 2018

Causes for litigation and risk management in facial surgery: a review of 136 cases.

J Stomatol Oral Maxillofac Surg 2018 Dec 14. Epub 2018 Dec 14.

Service de stomatologie et chirurgie maxillo-faciale, Assistance Publique des Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, 47-83, Boulevard de l'Hôpital 75651 Paris Cedex 13, France.

Introduction: Malpractice lawsuits in medicine and facial surgery are on the rise and they become an influencing factor in everyday practice for any surgeon.

Aim: We aim to analyze the possible causes for litigation in an effort to avoid these claims in the future.

Materials: One hundred and thirty litigation cases filed over a 10 year period (2005-2015) were evaluated. Read More

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December 2018

A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes.

Environ Res 2018 Dec 7;170:33-45. Epub 2018 Dec 7.

School of Public Health, Faculty of Medicine, University of Queensland, Herston, Australia; Centre for Air Pollution, Energy and Health Research, Glebe, NSW, Australia.

Ambient air pollution is the leading environmental risk factor for disease globally. Air pollutants can increase the risk of some respiratory infections, but their effects on tuberculosis (TB) are unclear. In this systematic literature review, we aimed to assess epidemiological studies on the association between outdoor air pollutants and TB incidence, hospital admissions and death (collectively referred to here as 'TB outcomes'). Read More

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December 2018

Construct validity of six sentiment analysis methods in the text of encounter notes of patients with critical illness.

J Biomed Inform 2018 Dec 14. Epub 2018 Dec 14.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Sentiment analysis may offer insights into patient outcomes through the subjective expressions made by clinicians in the text of encounter notes. We analyzed the predictive, concurrent, convergent, and content validity of six sentiment methods in a sample of 793,725 multidisciplinary clinical notes among 41,283 hospitalizations associated with an intensive care unit stay. None of these approaches improved early prediction of in-hospital mortality using logistic regression models, but did improve both discrimination and calibration when using random forests. Read More

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December 2018

Higher number of items associated with significantly lower response rates in COS Delphi surveys.

J Clin Epidemiol 2018 Dec 14. Epub 2018 Dec 14.

MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.

Objective: The Delphi method is commonly used to achieve consensus in core outcome set (COS) development. It is important to try to maximise response rates to Delphi studies, minimise attrition rates and potential for bias. The factors that impact response rates in a Delphi study used for COS development are unknown. Read More

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December 2018

Mechanistic modelling of Radium-223 treatment of bone metastases.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.

Introduction: Despite the effectiveness of RaCl for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions. In silico tumour models bring a new perspective to this as they can quantitatively simulate the interaction of α-particles with the target(s). Read More

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December 2018

Gene cloning, expression, molecular modeling and docking study of the protease SAPRH from Bacillus safensis strain RH12.

Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Microbial Biotechnology and Engineering Enzymes (LMBEE), Centre of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour, Km 6, P.O. Box 1177, Sfax 3018, Tunisia; Biotech ECOZYM Start-up, Business Incubator, Centre of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia. Electronic address:

The sapRH gene, which encodes the serine alkaline protease SAPRH, from Bacillus safensis RH12, was isolated and its DNA sequence was determined. The deduced amino-acid sequence showed strong homology with other Bacillus proteases. The highest sequence identity value (97%) was obtained with SAPB from B. Read More

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December 2018

A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Development of reverse genetics system for small ruminant morbillivirus: rescuing recombinant virus to express Echinococcus granulosus EG95 antigen.

Virus Res 2018 Dec 14. Epub 2018 Dec 14.

OIE Reference Laboratory for Peste des Petits Ruminants, National Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center, No.369 Nanjing Road, Qingdao, Shandong 266032, China. Electronic address:

Peste des petits ruminants and cystic hydatidosis may be simultaneously endemic in a given area. Their pathogens are small ruminant morbillivirus (SRMV) and Echinococcus granulosus (E. granulosus), respectively. Read More

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December 2018

Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2.

Exp Eye Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Faculty of Science, University of A Coruña, Spain. Electronic address:

The aim off the present study was to evaluate the effect and the mechanism of action of the conditioned medium from human uterine cervical stem cells (CM-hUCESC) on corneal wound healing in a rabbit dry eye model. To do this, dry eye and corneal epithelial injuries were induced in rabbits by topical administration of atropine sulfate and NaOH. Hematoxylin-Eosin (H&E) and Ki-67 immunostaining were carried out to evaluate corneal damage and cell proliferation, and real-time PCR was used to evaluate proinflammatory cytokines in the cornea. Read More

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December 2018

Variation in Implementation and Outcomes of Early Extubation Practices After Infant Cardiac Surgery.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Michigan Medicine C.S. Mott Children's Hospital, Department of Pediatrics, 1540 E. Hospital Drive, Ann Arbor, MI 48109.

Background: The Pediatric Heart Network Collaborative Learning Study (PHN CLS) increased early extubation after infant Tetralogy of Fallot (TOF) and coarctation repair overall at participating sites through implementing a clinical practice guideline (CPG). We evaluated variability across sites in CPG implementation and outcomes.

Methods: Patient characteristics and outcomes [time to extubation, length of stay (LOS)] were compared across sites, including pre- to post-CPG changes. Read More

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December 2018
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Considering the relationship between domestic violence and pet abuse and its significance in the veterinary clinical and educational contexts.

N Z Vet J 2018 Dec 17:1-27. Epub 2018 Dec 17.

a Department of Veterinary Clinical Sciences , University of Melbourne School , Werribee , Victoria , Australia 3030.

This thematic review examines the literature regarding the relationship between domestic violence (DV) and pet abuse (PA) particularly in the veterinary clinical and educational contexts. It examines the significance of this relationship for the veterinary profession including the veterinarian's role and associated legal and ethical obligations, and relevant current veterinary education standards, to identify future clinical and educational directions. Articles were sourced from online databases by searching the keywords without date restrictions. Read More

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December 2018

An Approach for Guiding the Development and Assessing the Interdisciplinarity of New Methodologies for Community Disaster Resilience.

Authors:
Elaina J Sutley

Risk Anal 2018 Dec 17. Epub 2018 Dec 17.

There are critical and preventable inequalities in disaster impacts and postdisaster recovery. To formulate solutions for minimizing or preventing these unequal impacts, there is a great need for interdisciplinary methodologies that use social factors to set project scopes and drive engineering analyses and designs. At present time, however, limited guidance exists on how to develop and execute interdisciplinary methodologies, especially related to the study of community disaster resilience. Read More

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December 2018

EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.

PLoS Pathog 2018 Dec 17;14(12):e1007484. Epub 2018 Dec 17.

Shenzhen Key Laboratory of Viral Oncology, the Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Read More

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December 2018

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan.

PLoS One 2018 17;13(12):e0206717. Epub 2018 Dec 17.

Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Japan is one of the few rabies-free countries/territories which implement the policy of mandatory vaccination of domestic dogs. In order to assess the economic efficiency of such policy in reducing the economic burden of a future canine rabies outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic decision tree modelling. Input data derived from simulation results of published mathematical model, field investigation conducted by the authors at prefectural governments, literature review, international or Japanese database and empirical data of rabies outbreaks in other countries/territories. Read More

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December 2018

Stable isotope signatures and nutritional sources of some dominant species from the PACManus hydrothermal area and the Desmos caldera.

PLoS One 2018 17;13(12):e0208887. Epub 2018 Dec 17.

Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R. China.

Deep-sea hydrothermal vents in the western Pacific are increasingly explored for potential mineral extraction. The study of the composition of the food web plays an important guiding role in the ecological protection and restoration of potential mining areas. The general picture of the nutritional sources of species should be established to assess the potential impacts of future mining activities on the biological composition and food sources. Read More

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December 2018

Continuous neuromuscular blockade infusion for out-of-hospital cardiac arrest patients treated with targeted temperature management: A multicenter randomized controlled trial.

PLoS One 2018 17;13(12):e0209327. Epub 2018 Dec 17.

Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.

Introduction: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM).

Methods: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. Read More

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December 2018

Public acceptability of development in the Northern Forest of Vermont, USA-The influence of wildlife information, recreation involvement, and demographic characteristics.

PLoS One 2018 17;13(12):e0203515. Epub 2018 Dec 17.

Vermont Department of Fish and Wildlife, Barre, Vermont, United States of America.

Increasing development such as roads and houses will alter future landscapes and result in biological, social, and economic trade-offs. Managing development requires information on the public's acceptability of development and understanding which factors shape acceptability. In this study, we examined three questions: 1) What is the public's acceptability of development? 2) Is acceptability of development influenced by wildlife information? and 3) Is the maximum amount of acceptable development influenced by views about wildlife, involvement in outdoor recreation, and demographic factors? We conducted a visual-preference survey of 9,000 households in Vermont, USA that asked about acceptable levels of development, acceptability of wildlife, involvement in recreation, and individual and town demographics. Read More

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December 2018

Insights into life after sport for Spanish Olympians: Gender and career path perspectives.

PLoS One 2018 17;13(12):e0209433. Epub 2018 Dec 17.

Department of Social Sciences Applied to Sport, Physical Activity and Leisure, Sport Sciences Faculty, Universidad Politécnica de Madrid, Madrid, Spain.

The aims of this study were: i) to examine if Dual Career (DC) pathways are independent of gender, ii) to evaluate whether those athletes who followed a DC experienced less difficulty in their integration into the labor force than the athletes devoted entirely to sport regardless of gender, as well as iii) to analyze whether the type of career path chosen was related with the current labor status, and if differences exist between men and women athletes. A quantitative, cross-sectional, and descriptive study was used based on an ad hoc questionnaire. Two-hundred and twenty-eight retired Olympic athletes completed a questionnaire. Read More

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December 2018

Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Level and determinants of birth preparedness and complication readiness among pregnant women: A cross sectional study in a rural area in Bangladesh.

PLoS One 2018 17;13(12):e0209076. Epub 2018 Dec 17.

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b); Mohakhali, Dhaka, Bangladesh.

Background: Increasing the level of birth preparedness and complication readiness (BP/CR) is one of the key interventions to promote optimal utilization of skilled maternal health services. It is therefore essential to determine the women's ability to recognize the danger signs and the level of BP/CR. This information can be used to design more effective health interventions. Read More

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December 2018

Identification of long intergenic non-coding RNAs (lincRNAs) deregulated in gastrointestinal stromal tumors (GISTs).

PLoS One 2018 17;13(12):e0209342. Epub 2018 Dec 17.

Institute for Digestive Research, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Long intergenic non-coding RNAs (lincRNAs) are >200 nucleotides long non-coding RNAs, which have been shown to be implicated in carcinogenic processes by interacting with cancer associated genes or other non-coding RNAs. However, their role in development of rare gastrointestinal stromal tumors (GISTs) is barely investigated. Therefore, the aim of this study was to define lincRNAs deregulated in GIST and find new GIST-lincRNA associations. Read More

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December 2018
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Health seeking for chronic lung disease in central Malawi: Adapting existing models using insights from a qualitative study.

PLoS One 2018 17;13(12):e0208188. Epub 2018 Dec 17.

Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

Background: Chronic lung diseases contribute to the growing non-communicable disease (NCD) burden and are increasing, particularly in many low and middle-income countries (LMIC) in sub-Saharan African. Early engagement with health systems in chronic lung disease management is critical to maintain quality of life and prevent further damage. Our study sought to understand health seeking behaviour in relation to chronic lung disease and TB in a rural district in Malawi. Read More

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December 2018
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Diagnosis and management of foetal alcohol specturm disorder.

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

FASD Specialist Behaviour Clinic, Surrey and Borders Partnership NHS Foundation Trust, Redhill, UK.

Purpose Of Review: Our understanding of the diagnosis and management of Foetal Alcohol Spectrum Disorders (FASD), has been increasingly refined in the last 45 years: This review highlights current understanding and identifies future areas for research.

Recent Findings: Newer techniques such as three-dimensional facial recognition and advanced brain imaging, have advanced our understanding. Despite this, there remain areas, such as the relationship with other neurodevelopmental disorders, that have been insufficiently explored. Read More

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December 2018

Stem cell therapies for Alzheimer's disease: is it time?

Curr Opin Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychiatry, Yeouido St. Mary's Hospital.

Purpose Of Review: Stem cell therapy has the potential to modify the disease of Alzheimer's disease. This article aims to describe the mechanisms of action, preclinical animal studies, human clinical trials, and challenges for the future direction of stem cell therapy for Alzheimer's disease.

Recent Findings: Stem cells of diverse origins (embryonic, placental or umbilical cord blood, and induced pluripotent stem cells) and cell types (neural and mesenchymal stem cells) are widely studied in both animals and humans. Read More

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December 2018

Correlation Between Pathologic Complete Response in the Breast and Absence of Axillary Lymph Node Metastases After Neoadjuvant Systemic Therapy.

Ann Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands.

Objective: The aim was to investigate whether pathologic complete response (pCR) in the breast is correlated with absence of axillary lymph node metastases at final pathology (ypN0) in patients treated with neoadjuvant systemic therapy (NST) for different breast cancer subtypes.

Background: Pathologic complete response rates have improved on account of more effective systemic treatment regimens. Promising results in feasibility trials with percutaneous image-guided tissue sampling for the identification of breast pCR after NST raise the question whether breast surgery is a redundant procedure. Read More

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December 2018

Quantifying Burn Injury-Related Disability and Quality of Life in the Developing World: A Primer for Patient-Centered Resource Allocation.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Department of Plastic Surgery, The University of Virginia, Charlottesville, VA.

Background: Untreated or undertreated burns are commonly encountered by plastic surgeons on medical trips in India and represent a major cause of disability. We sought to utilize validated patient-reported outcomes instruments to identify the patient population with the greatest burn-related disability in order to appropriately allocate plastic surgery resources to those in greatest need.

Methods: The Quick Disability of the Arm, Shoulder, and Hand, RAND 36-Item Short Form Health Survey, and Burn-Specific Health Scale-Revised, Brief, and Adapted questionnaires were administered via an interpreter during a plastic surgery trip to Jharkhand, India, in January 2018. Read More

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December 2018
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Differences of Immune Reconstitution of Dendritic Cells in Pediatric GvHD Patients After Allogenic Stem Cell Transplantation.

J Pediatr Hematol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatric Hematology and Oncology, University Hospital Würzburg, Germany.

Background: Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of (non) malignant conditions. GvHD is a severe complication with high morbidity and mortality. The pathogenesis remains unclear. Read More

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November 2018

Novel Immunotherapeutic Agents for the Treatment of Multiple Myeloma.

Am J Clin Oncol 2018 Dec 14. Epub 2018 Dec 14.

Division of Hematology/Oncology and GW Cancer Center, George Washington University School of Medicine and Health Sciences, Washington, DC.

Multiple myeloma (MM) is a B-cell malignancy characterized by the abnormal proliferation of clonal plasma cells in the bone marrow leading to end-organ manifestations. Despite the advancement in the therapy and care of patients with MM, relapse and resistance to standard therapy remain significant. The development of immunotherapy as a treatment modality for many types of cancers has led investigators to explore its use in MM in order to elicit myeloma-targeted immune responses, especially given that immune dysregulation is an underlying feature in the pathogenesis and progression of MM. Read More

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December 2018

Cognitive-behavioural and social factors do not predict recurrent secondary healthcare use in patients with fibromyalgia: a longitudinal study.

Clin Exp Rheumatol 2018 Nov 29. Epub 2018 Nov 29.

Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands.

Objectives: Healthcare use in fibromyalgia (FM) is relatively high. Besides disease-related variables, cognitive-behavioural factors have been concurrently associated with healthcare use. It is unknown whether cognitive-behavioural and social factors also predict future healthcare use. Read More

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November 2018

Photobiomodulation therapy in neuroischaemic diabetic foot ulcers: a novel method of limb salvage.

J Wound Care 2018 Dec;27(12):837-842

Assistant Professor-Senior Scale, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective:: Low-level laser therapy (also known as photobiomodulation therapy, PBMT) promotes accelerated healing of diabetic foot ulcers (DFUs), thereby preventing the risk of future complications and amputation. The aim of this study was to determine the effect of PBMT, with structured, graded mobilisation and foot care, on DFU healing dynamics.

Method:: Patients diagnosed with type 2 diabetes, diabetic peripheral neuropathy and presenting with a chronic neuroischaemic DFU, were treated with PBMT using scanning and non-contact probe methods. Read More

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December 2018

Disaster waste management after the 2016 Kumamoto Earthquake: A mini-review of earthquake waste management and the Kumamoto experience.

Waste Manag Res 2018 Dec 17:734242X18815948. Epub 2018 Dec 17.

3 Ministry of Environment, Japan.

Millions of tons of debris can be generated by natural disasters, impacting the surrounding environment and posing health risks to the public. Proper handling and treatment of such waste is essential to overcome potential hazards as well as to reduce the burden on natural resources during the reconstruction phase. Disaster waste management can have social, economic, and environmental benefits if planned effectively. Read More

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December 2018
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Risk Stratification for Screening Mammography: Benefits and Harms.

AJR Am J Roentgenol 2018 Dec 17:1-9. Epub 2018 Dec 17.

1 Department of Radiology, New York University Langone Health, 765 Stewart Avenue, 2nd Floor, Garden City, NY 11530.

Objective: The purpose of this article is to compare commonly used breast cancer risk assessment models, describe the machine learning approach and big data in risk prediction, and summarize the potential benefits and harms of restrictive risk-based screening.

Conclusion: The commonly used risk assessment models for breast cancer can be complex and cumbersome to use. Each model incorporates different sets of risk factors, which are weighted differently and can produce different results for the same patient. Read More

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December 2018

Cost-Utility Study of the Economics of Bunion Correction Surgery.

Foot Ankle Int 2018 Dec 17:1071100718815663. Epub 2018 Dec 17.

3 Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Background:: Bunion correction surgery is a very common procedure to improve patients' pain and physical function attributable to a misaligned first metatarsophalangeal joint. The objective of this study was to apply a health utility framework to estimate the cost utility of bunion correction surgery.

Methods:: Patients were prospectively recruited from the population of patients seen in a lower-extremity orthopedic clinic and scheduled for isolated bunion surgery. Read More

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December 2018
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