1,331 results match your criteria Functional Neurology[Journal]


An acute neurological complication of Crohn's disease.

Funct Neurol 2018 Jul/Sept;33(3):165-166

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November 2018

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.

Funct Neurol 2018 Jul/Sept;33(3):155-163

Neurite orientation dispersion and density imaging (NODDI), a MRI multi-shell diffusion technique, has offered new insights for the study of microstructural changes in neurodegenerative diseases. Mainly, the present study aimed to determine the connection between NODDI-derived parameters and changes in white matter (WM) abnormalities at early stages of amyotrophic lateral sclerosis (ALS). Spinal cords from ALS mice (G93A-SOD1 mice) were scanned in a Bruker Avance III HD 17. Read More

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November 2018
53 Reads
1.860 Impact Factor

Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats.

Funct Neurol 2018 Jul/Sept;33(3):149-153

The ventral tegmental area (VTA) is a brain region recently shown to interfere with pain perception. According to previous studies, improvement of antioxidant defense mechanisms reduces pain. The aim of this study was to show that lack of social interaction influences oxidative stress in the VTA and that this results in increased pain tolerance. Read More

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November 2018
5 Reads

Non-pharmacological interventions for agitation/aggressive behaviour in patients with dementia: a randomized controlled crossover trial.

Funct Neurol 2018 Jul/Sept;33(3):143-147

Agitation/aggressive behaviour is a common behavioural and psychological symptom in people with dementia (PwD), occurring with a frequency of between 13-50.4% according to recent studies, and the rate increases as the severity of cognitive decline increases. The burden on caregivers is considerable. Read More

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November 2018
7 Reads

The required coefficient of friction in Parkinson's disease: people with freezing of gait.

Funct Neurol 2018 Jul/Sept;33(3):137-142

The required coefficient of friction (RCOF) is frequently reported in the literature as an indicator of slip propensity, a consequence of the collisional aspect of legged locomotion. Little is known about the RCOF in pathological gait. Therefore, this study aimed to quantify the RCOF in subjects with Parkinson's disease (PD) and freezing of gait (FOG) during the OFF-pharma phase, and to investigate the interplay between RCOF parameters and ankle kinematic and kinetic gait variables. Read More

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November 2018
1 Read

Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.

Funct Neurol 2018 Jul/Sept;33(3):131-136

Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute stroke. Read More

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November 2018
1 Read

Effects of a nutraceutical combination in patients with chronic lumbosacral radicular pain.

Funct Neurol 2018 Jul/Sept;33(3):125-130

Drugs used for the treatment of chronic lumbosacral radicular pain (LRP) may have frequent adverse effects leading to medication withdrawal. The use of add-on nutraceuticals, which have no side effects, may therefore play a role in LRP treatment. We performed a six-week, single-center, open label prospective uncontrolled clinical study to evaluate the effect of a nutraceutical combination (Noxiall®) used as an add-on therapy in patients with chronic LRP. Read More

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November 2018
6 Reads

Chronic stroke: an oxymoron or a challenge for rehabilitation?

Funct Neurol 2018 Jul/Sept;33(3):123-124

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November 2018
1 Read

Development of a patient-centered questionnaire for post-stroke spasticity assessment: a reliability study.

Funct Neurol 2018 Apr/Jun;33(2):113-115

In the emerging scenario of patient-centered medicine, it is becoming increasingly important to involve patients in the management of chronic diseases. The rehabilitation field currently has no assessment tool for evaluating the functional impact of post-stroke spasticity on activities of daily living. The aim of this study was to identify a tool to fill this gap. Read More

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July 2018
1 Read

Laterality in Parkinson's disease may predict motor and visual imagery abilities.

Funct Neurol 2018 Apr/Jun;33(2):106-111

Experimental evidence suggests that motor imagery (MI) engages the same neural substrates supporting actual motor activities and is likely impaired when such substrates are damaged, as in Parkinson's disease (PD). MI intuitively relies on visual imagery (VI), because mental simulations of physical movements depend on the visual retrieval of these movements. Although VI is generally considered a right hemispheric function, the hemispheric dominance of MI is still in dispute. Read More

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July 2018
5 Reads

Epidemiological and clinical characteristics of 492 patients in a vegetative state in 29 Italian rehabilitation units. What about outcome?

Funct Neurol 2018 Apr/Jun;33(2):97-103

Recent studies on recovery of consciousness of subjects in a vegetative state (VS) admitted to rehabilitation units have focused mainly on the identification of prognostic factors, whereas few studies have focused on outcome. The aim of this study was to compare demographic and clinical data and report functional outcome of patients in a VS due to severe acquired brain injury (ABI) of different aetiologies. The study was a retrospective multicentre cohort study and involved 492 patients in a VS due to traumatic (TBI) or non-traumatic (NTBI) severe ABI admitted to 29 Italian rehabilitation units. Read More

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July 2018
4 Reads

Impact of epilepsy after severe brain injury on safe resumption of driving: two-year follow-up.

Funct Neurol 2018 Apr/Jun;33(2):91-95

Safe resumption of driving after a severe acquired brain injury (sABI) is a strongly felt need because driving is related to recovery of independence and social-occupational re-integration. The aim of this prospective observational cohort study was to determine whether epilepsy secondary to sABI is a significant factor for being declared fit to drive by the relevant government authorities in Italy. In the period 2006-2015 we recruited 187 patients with sABI, 30 of whom (16. Read More

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Direction-specific cortical response immediately after moving tactile stimuli in female humans.

Funct Neurol 2018 Apr/Jun;33(2):81-89

This study looked for a direction-specific cortical response immediately after application of moving tactile stimuli in healthy female humans. Four pairs of stimulus electrodes were placed over the left index finger pulp on the distal-proximal axis. Four times, once in every 40 ms interval, an electrical stimulus to the finger pulp was delivered through one of the four pairs of electrodes; each time the stimulus site changed in order to induce a sensation of tactile motion. Read More

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July 2018
1 Read

A review of 500 patients with acute stroke admitted to the University Hospital of Saudi Arabia. Similarities and differences compared with the published literature.

Authors:
A Zafar

Funct Neurol 2018 Apr/Jun;33(2):73-79

Published studies have shown differences in types and underlying mechanisms of stroke between different regions of the world. There is a lack of published literature describing the characteristics of acute stroke in Saudi Arabia. The aim of this study was to identify different types and associated risk factors among acute stroke patients in Saudi Arabia. Read More

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Understanding the pathophysiology of hyperglycemia-associated chorea-ballism: a systematic review of positron emission tomography findings.

Funct Neurol 2018 Apr/Jun;33(2):67-72

Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported demographic, clinical, laboratory and imaging data from patients with HCB in whom a PET scan had been performed. Read More

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July 2018
1 Read

Effectiveness of a digital platform for sharing knowledge on headache management: a two-year experience.

Funct Neurol 2018 Jan/Mar;33(1):51-55

It is crucial that all headache specialists receive adequate training. Considering the unsatisfactory results obtained with standard updating courses and the growing need for continuing professional education, a digital platform was developed as a training tool. The platform has been active since 1 October 2014. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901942PMC
April 2018
2 Reads

A role for accelerometry in the differential diagnosis of tremor syndromes.

Funct Neurol 2018 Jan/Mar;33(1):45-49

Accelerometry is a reliable tool for gauging the occurrence, amplitude and frequency of tremor. However, there is no consensus on criteria for accelerometric diagnosis of tremor syndromes. We enrolled 20 patients with essential tremor (ET), 20 with dystonic tremor (DT), and 20 with classic parkinsonian tremor (PD-T), all meeting accepted clinical criteria. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901940PMC
April 2018
1 Read

Management of spasticity with onabotulinumtoxinA: practical guidance based on the italian real-life post-stroke spasticity survey.

Funct Neurol 2018 Jan/Mar;33(1):37-43

The present paper provides practical guidance on the management of adult spasticity with OnabotulinumtoxinA. Advisory Board members reviewed the available evidence and discussed their personal experiences in order to address the unmet needs in the management of spasticity with botulinum toxin type A identified by the recent Italian Real-Life Post-Stroke Spasticity Survey. Stroke patients should be referred to spasticity services that have adequate facilities and multidisciplinary teams with the necessary training, competence and expertise. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901939PMC
April 2018
8 Reads

Apathy in Parkinson's disease: differences between caregiver's report and self-evaluation.

Funct Neurol 2018 Jan/Mar;33(1):31-35

Apathy is a state of diminished goal-directed speech, motor activity and emotions. The prevalence of apathy in Parkinson's disease (PD) ranges from 16 to 62%. Several studies have investigated the relationships between apathy and other dimensions of PD, but little is known about possible discrepancies between self-evaluation (SE) and caregiver reporting (CR) of this symptom. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901938PMC
April 2018
2 Reads

Multicentre registry of brain-injured patients with disorder of consciousness: rationale and preliminary data.

Funct Neurol 2018 Jan/Mar;33(1):19-30

Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On the basis of this consideration, we devised a multicentre prospective registry for patients with DoC admitted to ten intensive rehabilitation units. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901937PMC
April 2018
2 Reads

Pharmacological differences and clinical implications of various botulinum toxin preparations: a critical appraisal.

Funct Neurol 2018 Jan/Mar;33(1):7-18

Three different type A botulinum neurotoxins (BoNTAs) - onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA) - are currently marketed in Europe to treat several conditions. Differences between BoNTA preparations, which depend on their specific biotypes and manufacturing processes, lead to clinically relevant pharmacotherapeutic dissimilarities. All three available products are separately recognized and reviewed in American Academy of Neurology guidelines. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901944PMC
April 2018
2 Reads

Add-on perampanel and aggressive behaviour in severe drug-resistant focal epilepsies.

Authors:
S Juhl G Rubboli

Funct Neurol 2017 Oct/Dec;32(4):215-220

This study aimed to investigate the incidence of aggressiveness in patients with severe drug-refractory focal epilepsy (DRE) who started perampanel (PER) as add-on treatment, and to identify possible predisposing factors. Data on 49 consecutive patients with severe DRE who initiated PER were retrospectively collected. Twelve of the 49 patients experienced aggressiveness as adverse event related to PER treatment, one third of them on low (2-4 mg/day) PER dosages. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762107PMC
August 2018
4 Reads

The need for better access to pain treatment: learning from drug consumption trends in the USA.

Funct Neurol 2017 Oct/Dec;22(4):229-230

The Authors of this letter look at consumption of opioids and a2- ligands, also known as "gabapentinoids", in Italy, and specifically in the Provincial Health District of Cosenza, as compared with USA trends of recent decades. Access to analgesic drugs since the introduction of Italian law 38/2010 is also evaluated and possible future measures for better management of chronic pain are proposed. Read More

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August 2018
3 Reads

The culturally adapted Italian version of the Barthel Index (IcaBI): assessment of structural validity, inter-rater reliability and responsiveness to clinically relevant improvements in patients admitted to inpatient rehabilitation centers.

Funct Neurol 2017 Oct/Dec;22(4):221-228

The Barthel Index (BI) is widely used to determine eligibility criteria for inpatient rehabilitation and to monitor patients' recovery, irrespective of the illnesses that affect them. The culturally adapted Italian version of the Barthel Index (IcaBI) was recently validated. This paper reports the structural validity and inter-rater reliability of the IcaBI and its responsiveness to the results of inpatient rehabilitation. Read More

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August 2018
8 Reads

Foreground and background: an interview with Peter Singer and three arguments against naturalism.

Authors:
A Loffi

Funct Neurol 2017 Oct/Dec;22(4):211-214

The first part of this paper reports an interview with the philosopher Peter Singer. In the second, we examine Singer's background: naturalism and neurophilosophy, discussing three of its theses, as presented by Patricia Smith Churchland. Finally, we go back to Singer himself, to draw some conclusions. Read More

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August 2018
2 Reads

Apathy in corticobasal degeneration: possible parietal involvement.

Funct Neurol 2017 Oct/Dec;22(4):201-210

Corticobasal degeneration is a rare disorder, which usually consists of a combination of complex movement disorders, apraxia and cortical changes. Its definition is still evolving and in 2013 an international consortium tried to develop new criteria, based on a systematic literature review. Over a long period of time, we carefully selected 23 patients who fulfilled the criteria for a diagnosis of corticobasal degeneration; all had the so-called corticobasal syndrome phenotype, in accordance with Armstrong et al. Read More

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August 2018
5 Reads

The usefulness of sLORETA in evaluating the effect of high-dose ARA-C on brain connectivity in patients with acute myeloid leukemia: an exploratory study.

Funct Neurol 2017 Oct/Dec;22(4):195-200

Cytosine arabinoside (Ara-C) is one of the key drugs for treating acute myeloid leukemia (AML). High intravenous doses may produce a number of central nervous system (CNS) toxicities and contribute to modifications in brain functional connectivity. sLORETA is a software used for localizing brain electrical activity and functional connectivity. Read More

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August 2018
4 Reads

Neurophysiology of the pelvic floor in clinical practice: a systematic literature review.

Funct Neurol 2017 Oct/Dec;22(4):173-193

Neurophysiological testing of the pelvic floor is recognized as an essential tool to identify pathophysiological mechanisms of pelvic floor disorders, support clinical diagnosis, and aid in therapeutic decisions. Nevertheless, the diagnostic value of these tests in specific neurological diseases of the pelvic floor is not completely clarified. Seeking to fill this gap, the members of the Neurophysiology of the Pelvic Floor Study Group of the Italian Clinical Neurophysiology Society performed a systematic review of the literature to gather available evidence for and against the utility of neurophysiological tests. Read More

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August 2018
6 Reads

Analysis of Italian regulations on pathways of care for patients in a vegetative or minimally conscious state.

Funct Neurol 2017 Jul/Sep;32(3):159-163

Different rehabilitation models for persons diagnosed with disorders of consciousness have been proposed in Europe during the last decade. In Italy, the Ministry of Health has defined a national healthcare model, although, to date, there is a lack of information on how this has been implemented at regional level. The INCARICO project collected information on different regional regulations, analysing ethical aspects and mapping care facilities (numbers of beds and medical units) in eleven regional territories. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726352PMC
June 2018
2 Reads

Quantitative, functional MRI and neurophysiological markers in a case of Gerstmann-Sträussler-Scheinker syndrome.

Funct Neurol 2017 Jul/Sep;32(3):153-158

Gerstmann-Sträussler-Scheinker syndrome (GSS) is an inherited autosomal dominant prion disease, caused by a codon 102 proline to leucine substitution (P102L) in the prion protein gene (PRNP). We describe the case of a 40-year-old male, affected by a slowly progressive gait disturbance, leg weakness and cognitive impairment. Genomic DNA revealed a point mutation of PRNP at codon 102, resulting in P102L, and the diagnosis of GSS was confirmed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726351PMC
June 2018
8 Reads

Pisa syndrome in Parkinson's disease: electromyographic quantification of paraspinal and non-paraspinal muscle activity.

Funct Neurol 2017 Jul/Sep;32(3):143-151

Patients with Parkinson's disease (PD) and Pisa syndrome (PS) may present tonic dystonic or compensatory (i.e. acting against gravity) hyperactivity in the paraspinal and non-paraspinal muscles. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726350PMC
June 2018
3 Reads

Obstructive sleep apnea syndrome in Parkinson's disease and other parkinsonisms.

Funct Neurol 2017 Jul/Sep;32(3):137-141

An association of obstructive sleep apnea syndrome (OSAS) and other sleep-disordered breathing (SDB) with Parkinson's disease (PD) has been reported in some small studies. In the present study we investigated the occurrence of SDB in a large consecutive outpatient series. This is a case-control study in subjects attending a neurological clinic where all patients were screened for SDB by means of sleep-wake history, Epworth Sleepiness Scale, and full-night polysomnography, when indicated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726349PMC
June 2018
8 Reads

Recovery from vegetative state of patients with a severe brain injury: a 4-year real-practice prospective cohort study.

Funct Neurol 2017 Jul/Sep;32(3):131-136

Patients who have suffered severe traumatic or nontraumatic brain injuries can show a progressive recovery, transitioning through a range of clinical conditions. They may progress from coma to a vegetative state (VS) and/or a minimally conscious state (MCS). A longer duration of the VS is known to be related to a lower probability of emergence from it; furthermore, the literature seems to lack evidence of late improvements in these patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726348PMC
June 2018
2 Reads

Nociceptive blink reflex habituation biofeedback in migraine.

Funct Neurol 2017 Jul/Sep;32(3):123-130

Reduced habituation of the nociceptive blink reflex (NBR) is considered a trait marker for genetic predisposition to migraine. In this open-label randomized controlled study, we aimed to test the efficacy of a biofeedback training based on learning of habituation of the NBR (NBR biofeedback) compared with pharmacological (topiramate) treatment and NBR biofeedback plus topiramate treatment in a cohort of migraine without aura patients eligible for prophylaxis. Thirty-three migraine patients were randomly assigned to three months of treatment with: 1) NBR biofeedback, 2) NBR biofeedback plus topiramate 50 mg (b. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726347PMC
June 2018
4 Reads

Electrodiagnostic and nerve ultrasonographic features in upper limb spasticity: an observational study.

Funct Neurol 2017 Jul/Sep;32(3):119-122

To better understand the effects of spasticity on peripheral nerves, we evaluated the electrodiagnostic and nerve ultrasonographic features of the median and ulnar nerves in adults with upper limb spasticity. Twenty chronic stroke patients with spastic hemiparesis underwent nerve conduction study and nerve ultrasonography of the median and ulnar nerves at both upper limbs. Affected versus unaffected upper limb comparisons showed significant differences in the median and ulnar nerve distal motor latencies, compound muscle action potentials and F-wave minimal latencies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726346PMC
June 2018
3 Reads

Rethinking dementias.

Funct Neurol 2017 Jul/Sep;32(3):117-118

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726345PMC
June 2018
2 Reads

Ixcellence Network®: an international educational network to improve current practice in the management of cervical dystonia or spastic paresis by botulinum toxin injection.

Funct Neurol 2017 Apr/Jun;32(2):103-110

Botulinum toxin is a well-established treatment for a number of conditions involving muscle hyperactivity, such as focal dystonia and spastic paresis. However, current injection practice is not standardized and there is a clear need for structured training. An international group of experts in the management of patients with cervical dystonia (CD) and spastic paresis created a steering committee (SC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507152PMC
January 2018
9 Reads

Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study.

Funct Neurol 2017 Apr/Jun;32(2):97-101

Diffusion tensor imaging (DTI) is sensitive to white matter (WM) damage in multiple sclerosis (MS), not only in focal lesions but also in the normal-appearing WM (NAWM). However, DTI indices can also be affected by natural spatial variation in WM, as seen in crossing and dispersing white matter fibers. Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion-weighted imaging technique that provides distinct indices of fiber density and dispersion. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507159PMC
January 2018
7 Reads

The Italian real-life post-stroke spasticity survey: unmet needs in the management of spasticity with botulinum toxin type A.

Funct Neurol 2017 Apr/Jun;32(2):89-96

The present national survey seeking to identify unmet needs in the management of spasticity with botulinum toxin type A focused on the use of OnabotulinumoxinA, since this is the brand with the widest range of licensed indications in Italy. Physicians from twenty-four Italian neurorehabilitation units compiled a questionnaire about "real-life" post-stroke spasticity management. OnabotulinumtoxinA was reported to be used in the following average doses: upper limb 316. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507158PMC
January 2018
9 Reads

HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family.

Funct Neurol 2017 Apr/Jun;32(2):83-88

Environmental and genetic factors seem to play a pathogenetic role in multiple sclerosis (MS). The genetic component is partly suggested by familial aggregation of cases; however, MS families with affected subjects over different generations have rarely been described. The aim of this study was to report clinical and genetic features of a multigenerational MS family and to perform a review of the literature on this topic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507157PMC
January 2018
1 Read

Cerebellar transcranial static magnetic field stimulation transiently reduces cerebellar brain inhibition.

Funct Neurol 2017 Apr/Jun;32(2):77-82

The aim of this study was to investigate whether transcranial static magnetic field stimulation (tSMS) delivered using a compact cylindrical NdFeB magnet over the cerebellum modulates the excitability of the cerebellum and contralateral primary motor cortex, as measured using cerebellar brain inhibition (CBI), motor evoked potentials (MEPs), and resting motor threshold (rMT). These parameters were measured before tSMS or sham stimulation and immediately, 5 minutes and 10 minutes after stimulation. There were no significant changes in CBI, MEPs or rMT over time in the sham stimulation condition, and no changes in MEPs or rMT in the tSMS condition. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507156PMC
January 2018
3 Reads

Object decision and multiple sclerosis: a preliminary study.

Funct Neurol 2017 Apr/Jun;32(2):69-75

The aim of this research was to study cognitive dysfunctions in multiple sclerosis (MS) by exploring subtle cognitive tasks, usually not included in the standard neuropsychological assessment. We wished to investigate whether it is possible to identify object decision deficits in MS patients without evident cognitive impairment; secondary objectives were to understand whether these deficits can be detected in the early stages of the disease and whether there are differences related to different phenotypes. Participants were divided into four groups: (a) 12 patients with early relapsing-remitting MS [ERR]; (b) 14 with late relapsing-remitting MS [LRR]; (c) 10 with secondary progressive MS [SP]; (d) 36 healthy controls [HCs]. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507155PMC
January 2018
2 Reads

European core curriculum in neurorehabilitation.

Funct Neurol 2017 Apr/Jun;32(2):63-68

To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation should include a two-year residency in a neurorehabilitation setting where trainees can gain practical experience. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507154PMC
January 2018
14 Reads