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    [Skin diseases associated with environmental factors].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 May 17. Epub 2017 May 17.
    Abteilung Allergologie, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
    Background: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease.

    Objectives: Provide an overview of non-allergic skin diseases associated with environmental factors.

    Materials And Methods: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. Read More

    A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy.
    Adv Wound Care (New Rochelle) 2017 May;6(5):143-152
    Angie Purvis, LLC, Evergreen, Colorado.
    Objective: Topical oxygen devices are Food and Drug Administration (FDA) cleared for the following indications for use of various etiologies: skin ulcerations due to diabetes, venous stasis, postsurgical infections and gangrenous lesions, decubitus ulcers; amputations/infected stumps; skin grafts; burns; and frostbite. The goal of this study was to understand the impact of topical oxygen therapy (TOT) on patient outcomes, including amputation and healing rates. Approach: This retrospective chart review included records collected between January 1, 2007, and July 18, 2016, from male and female patients ranging in age from 4 years to 105 years. Read More

    Thermal perception thresholds among workers in a cold climate.
    Int Arch Occup Environ Health 2017 May 11. Epub 2017 May 11.
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, 901 87, Umeå, Sweden.
    Purpose: To investigate whether exposure to cold could influence the thermal perception thresholds in a working population.

    Methods: This cross-sectional study was comprised of 251 males and females and was carried out at two mines in the northern part of Norway and Sweden. The testing included a baseline questionnaire, a clinical examination and measurements of thermal perception thresholds, on both hands, the index (Digit 2) and little (Digit 5) fingers, for heat and cold. Read More

    Battlefield Trauma-Induced Hypothermia: Transitioning the Preferred Method of Casualty Rewarming.
    Wilderness Environ Med 2017 May 5. Epub 2017 May 5.
    Department of Surgery, Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas (Holcomb).
    For centuries, cold and wet weather has affected military combat operations leading to tremendous loss of manpower caused by cold-weather-related injuries including trench foot, frostbite, and hypothermia. The initial battlefield management of hypothermia in military personnel had not advanced significantly following many wars and conflicts until 2006. The aim of this review is to: 1) provide an overview of trauma-induced hypothermia (TIH); 2) highlight the Department of Defense strategy for the implementation of a hypothermia clinical management program for battlefield (prehospital) casualties; 3) highlight the research and development of the Hypothermia Prevention and Management Kit (HPMK) as the preferred field rewarming system for battlefield TIH; and 4) emphasize how the HPMK can be easily transitioned to the civilian sector for active rewarming of both accidental and TIH patients. Read More

    Stress injuries and autophagy in mouse hippocampus after chronic cold exposure.
    Neural Regen Res 2017 Mar;12(3):440-446
    Institute of Neurobiology, College of Life Science, Henan University, Kaifeng, Henan Province, China.
    Cold exposure is an external stress factor that causes skin frostbite as well as a variety of diseases. Estrogen might participate in neuroprotection after cold exposure, but its precise mechanism remains unclear. In this study, mice were exposed to 10°C for 7 days and 0-4°C for 30 days to induce a model of chronic cold exposure. Read More

    A new treatment for frostbite sequelae; Botulinum toxin.
    Int J Circumpolar Health 2017 ;76(1):1273677
    e Department of Radiology , University Hospital North Norway, Tromsø , Norway.
    Frostbite sequelae are a relevant occupational injury outcome for soldiers in arctic environments. A Caucasian male soldier suffered frostbite to both hands during a military winter exercise. He developed sensory-motor disturbances and cold hypersensitivity. Read More

    Frostbite.
    Emerg Med Clin North Am 2017 May;35(2):281-299
    Department of Vascular Surgery, University Hospital Coventry and Warwickshire NHS Trust, Warwick Medical School and Coventry University, Coventry, UK.
    Deep frostbite is a thermal injury associated with significant morbidity. Historically, this has been associated with military personnel; however, increasingly it is becoming an injury that afflicts the civilian population. The use of intravenous iloprost or intra-arterial thrombolytics has led to promising tissue salvage. Read More

    Neurovascular hand symptoms in relation to cold exposure in northern Sweden: a population-based study.
    Int Arch Occup Environ Health 2017 Apr 11. Epub 2017 Apr 11.
    Department of Public Health and Clinical Medicine, Umeå University, 901 87, Umeå, Sweden.
    Purpose: To describe the self-reported ambient cold exposure in northern Sweden and to relate the level of cumulative cold exposure to the occurrence of sensory and vascular hand symptoms. We hypothesize that cold exposure is positively related to reporting such symptoms.

    Methods: A questionnaire about cold exposure and related symptoms was sent out to 35,144 subjects aged 18-70 years and living in northern Sweden. Read More

    Frostbite following cryolipolysis treatment in a beauty salon: a case study.
    J Wound Care 2017 Apr;26(4):188-190
    Specialty Registrar in Plastic Surgery, Department of Plastic Surgery, St John's Hospital, Edinburgh, Scotland, UK.
    This case study describes frostbite, a previously unreported complication following cryolipolysis, which resulted in substantial necrosis of the flank. Medical attention was not sought until one week after treatment. On examination, two distinct areas of significant frostbite in the left flank with surrounding erythema were revealed. Read More

    Cold Injuries.
    Hand Clin 2017 May;33(2):257-267
    The University of Chicago Medicine, 5841 South Maryland Avenue, MC 6035, Chicago, IL 60637, USA. Electronic address:
    New treatments of frostbite have led to unprecedented salvage of extremities including fingers and toes. Success is predicated on prompt institution of time-sensitive protocols initiated soon after rewarming, particularly the use of thombolytics. Unfortunately, in the urban setting, most patients are not candidates for these treatment modalities. Read More

    A 3D thermal model to analyze the temperature changes of digits during cold stress and predict the danger of frostbite in human fingers.
    J Therm Biol 2017 Apr 6;65:153-160. Epub 2017 Mar 6.
    Foolad Institute of Technology, Fooladshahr, Isfahan 84916-63763, Iran.
    The existing computational models of frostbite injury are limited to one and two dimensional schemes. In this study, a coupled thermo-fluid model is applied to simulate a finger exposed to cold weather. The spatial variability of finger-tip temperature is compared to experimental ones to validate the model. Read More

    Microangiography to Monitor Treatment Outcomes Following Severe Frostbite Injury to the Hands.
    J Burn Care Res 2017 Mar 15. Epub 2017 Mar 15.
    From the Hennepin County Medical Center, Minneapolis, Minnesota.
    Frostbite injury causes direct damage to tissues following exposure to temperatures below their freezing point causing tissue death potentially leading to serious amputations. After rewarming, a variety of treatment options have been employed to avoid amputation. This case report details the use of indocyanine green fluorescence microangiography to monitor the clinical progression of perfusion following hyperbaric oxygen therapy (HBOT) for severe frostbite injury. Read More

    Sport Injuries of the Ear and Temporal Bone.
    Clin Sports Med 2017 Apr;36(2):315-335
    Department of Otorhinolaryngology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address:
    In cases of head trauma, the ear should be evaluated in all of its components. A good understanding of otologic and skull base anatomy enables a thorough trauma assessment of this complex anatomic region. Auricular laceration, abrasion, avulsion, hematoma, frostbite, otitis externa, exostosis, tympanic membrane perforation, ossicular discontinuity, perilymphatic fistula, labyrinthine concussion, temporal bone fracture, facial nerve paresis, and sensorineural hearing loss are a few of the more common otologic injuries seen in active patients. Read More

    The Use of Thrombolytic Therapy in the Treatment of Frostbite Injury.
    J Burn Care Res 2017 Mar 3. Epub 2017 Mar 3.
    From the Department of Pharmacy, Loyola University Medical Center, Maywood, Illinois.
    Frostbite can lead to severe consequences including loss of digits and limbs. One of the mechanisms of frostbite includes vascular thrombosis. The use of tissue plasminogen activator (tPA) in frostbite has been shown to be effective in case reports and small prospective studies. Read More

    Use and Effectiveness of Ethyl Chloride for Hand Injections.
    J Hand Surg Am 2017 Mar;42(3):175-181.e1
    Department of Orthopedic Surgery, University of Cincinnati, Cincinnati, OH.
    Purpose: Limited literature supports using ethyl chloride topical spray as an anesthetic for hand injections whereas documented risks include frostbite, skin irritation, and inhalation toxicity. We hypothesize that ethyl chloride spray imparts no benefit to patients' perception of pain or anxiety for routine hand injections.

    Methods: We first surveyed all members of the American Society for Surgery of the Hand to discern the prevalence of ethyl chloride use during routine injections. Read More

    High Altitude Dermatology.
    Indian J Dermatol 2017 Jan-Feb;62(1):59-65
    Department of Dermatology, Military Hospital, Ahmedabad, Gujarat, India.
    Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Read More

    Burns and frostbite in the Red Army during World War II.
    Mil Med Res 2017 8;4. Epub 2017 Feb 8.
    Department of Thermal Injuries of the S.M. Kirov Military Medical Academy, Major of Medical Service, Zagorodnyy Prospect, 47, 190013 Saint-Petersburg, Russia.
    The start of World War II (WWII) led to the deployment of combat troops in several continents. Destruction and many casualties among both the military and civilians became an inevitable consequence. A large amount of people injured were in need of life-saving treatment and a speedy return to duty. Read More

    Assessing the effectiveness of topical betamethasone to treat chronic chilblains: a randomised clinical trial in primary care.
    Br J Gen Pract 2017 Mar 13;67(656):e187-e193. Epub 2017 Feb 13.
    Department of Primary and Community Care, Gender and Women's Health; Radboud University Medical Centre, Nijmegen, the Netherlands.
    Background: GPs prescribe topical corticosteroids to patients with chronic chilblains despite poor evidence for their effectiveness. The authors of the current study therefore decided to assess the effectiveness of topical steroids in a primary care setting.

    Aim: To assess the effectiveness of topical application of betamethasone valerate 0. Read More

    The use of intravenous tPA for the treatment of severe frostbite.
    Burns 2017 Jan 31. Epub 2017 Jan 31.
    Department of Surgery, Division of Critical Care, Trauma and Burn, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address:
    Objective: tPA and anticoagulation for treatment of severe frostbite have been reported suggesting differences in imaging techniques, route of tPA administration and management of patients after tPA infusion. This is a report of our results following a protocol of Tc-99m scanning, intravenous tPA administration, followed by either systemic anticoagulation or antiplatelet therapy.

    Methods: Patients admitted to our burn center between February 13, 2015 and February 13, 2016 for frostbite who met inclusion criteria were treated with Tc-99m scan and intravenous tPA followed by systemic anticoagulation or antiplatelet therapy. Read More

    The effectiveness of regional cooling for paclitaxel-induced peripheral neuropathy.
    J Pharm Health Care Sci 2016 15;2:33. Epub 2016 Nov 15.
    Department of Pharmacy, Iwate Medical University Hospital, 19-1 Uchimaru, Morioka, Iwate, 020-8505 Japan ; Department of Clinical Pharmaceutics, School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate, 028-3694 Japan.
    Background: There are currently no promising therapies available to treat or prevent peripheral neuropathy (PN) induced by anticancer drugs in a cumulative dose-dependent manner. In this study, we investigated the efficacy of regional cooling of hands and feet in preventing paclitaxel (PTX)-induced PN.

    Methods: Patients with gynecologic cancer who received a tri-weekly cycle of chemotherapy including PTX at doses of 150-175 mg/m(2) were included in this study. Read More

    Dull Brains and Frozen Feet: A Historical Essay on Cold.
    Wilderness Environ Med 2016 Dec 3;27(4):526-532. Epub 2016 Nov 3.
    Endocrinology and Nuclear Thyroidology, Richmond, VA. Electronic address:
    This essay will review historical and medical aspects of cold exposure, hypothermia, and frostbite during the Napoleonic era. The 19th century writings of Dominique Jean Larrey, Pierre Jean Moricheau-Beaupré, and others are used to provide an evocative supporting narrative to illustrate some of the cold illnesses, physiology, and theory of both an earlier era and the present time. Medical care for over a century followed the how but not the why of treating frostbite and hypothermia slowly with snow or cold water rather than heat. Read More

    Effect of sodium nitrite on local control of contracting skeletal muscle microvascular oxygen pressure in healthy rats.
    J Appl Physiol (1985) 2017 Jan 27;122(1):153-160. Epub 2016 Oct 27.
    Department of Kinesiology, Kansas State University, Manhattan, Kansas; and
    Exercise intolerance characteristic of diseases such as chronic heart failure (CHF) and diabetes is associated with reduced nitric oxide (NO) bioavailability from nitric oxide synthase (NOS), resulting in an impaired microvascular O2 driving pressure (Po2mv; O2 delivery/O2 utilization) and metabolic control. Infusions of the potent NO donor sodium nitroprusside augment NO bioavailability yet decrease mean arterial pressure (MAP) thereby reducing its potential efficacy for patient populations. To eliminate or reduce hypotensive sequelae, [Formula: see text] was superfused onto the spinotrapezius muscle. Read More

    Update: Cold weather injuries, active and reserve components, U.S. Armed Forces, July 2011-June 2016.
    MSMR 2016 Oct;23(10):12-20
    From July 2015 through June 2016, a total of 447 members of the active (n=383) and reserve (n=64) components had at least one medical encounter with a primary diagnosis of cold injury. The numbers of affected individuals in both components were the lowest since the 2011-2012 cold season, when the total was 394. In the active component, the service-specific incidence rates for each of the four services were lower than the respective rates for the previous (2014-2015) cold season. Read More

    Effects of low-frequency pulsed electromagnetic fields on plateau frostbite healing in rats.
    Wound Repair Regen 2016 Nov 12;24(6):1015-1022. Epub 2016 Oct 12.
    The Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China.
    Plateau frostbite (PF) treatments have remained a clinical challenge because this condition injures tissues in deep layers and affected tissues exhibit unique pathological characteristics. For instance, low-frequency pulsed electromagnetic field (PEMF) can affect tissue restoration and penetrate tissues. Therefore, the effect of PEMF on PF healing should be investigated. Read More

    A retrospective cohort study examining treatments and operative interventions for frostbite in a tertiary care hospital.
    CJEM 2017 Mar 22;19(2):88-95. Epub 2016 Sep 22.
    *University of Ottawa, Faculty of Medicine,Ottawa Hospital Research Institute,Ottawa,ON.
    Background: Frostbite is a common yet challenging injury to both diagnose and treat. McCauley's frostbite treatment protocol consists of 12 treatments that might well represent the standard of care. However, its effectiveness in preventing operative intervention has yet to be examined. Read More

    Initial Experience: Alleviation of Pain with Percutaneous CT-Guided Cryoablation for Recurrent Retroperitoneal Soft-Tissue Sarcoma.
    J Vasc Interv Radiol 2016 Dec 9;27(12):1798-1805. Epub 2016 Sep 9.
    Departments of Interventional Oncology Guangzhou, China. Electronic address:
    Purpose: To evaluate the pain-alleviating effect of computed tomography (CT)-guided percutaneous cryoablation for recurrent retroperitoneal soft-tissue sarcomas (RPSs).

    Materials And Methods: Data from 19 men and 20 women (median age, 50.3 y) with recurrent malignant RPS who underwent percutaneous cryoablation were reviewed retrospectively. Read More

    Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation).
    Chest 2016 Sep;150(3):e65-71
    Pediatric Pulmonology Department, Hôpital Femme-Mère-Enfant, Hospices civils de Lyon, UMR5558, Lyon, France. Electronic address:
    We report three cases of pulmonary disease suggesting fibrosis in two familial and one sporadic case. Pulmonary symptoms were associated with various clinical features of systemic inflammation and vasculitis involving the skin, and appeared at different ages. A strong interferon signature was found in all three cases. Read More

    Application of a novel rectal cooling device in hypothermia therapy after cerebral hypoxia-ischemia in rats.
    BMC Anesthesiol 2016 Sep 9;16:77. Epub 2016 Sep 9.
    Department of PICU, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
    Background: A new rectal cooling device for therapeutic hypothermia (TH) therapy is designed and is applied in TH treatment of SD rats with ischemic-hypoxic brain damage.

    Methods: Healthy adult SD rats (n = 45) were randomly assigned into four groups: the healthy control group (n = 5), the ischemia and hypoxia group (n = 10), the rectal TH cooling group (n = 18), and the ice blanket TH cooling group (n = 11). The rats in the rectal cooling and ice blanket TH groups received 12 h treatment after hypoxic-ischemic brain damage had been established, while those in the ischemia and hypoxia group did not. Read More

    Time Matters in Severe Frostbite: Assessment of Limb/Digit Salvage on the Individual Patient Level.
    J Burn Care Res 2017 Jan/Feb;38(1):53-59
    From the Department of Surgery, Hennepin County Medical Center, Minneapolis, Minnesota.
    Severe frostbite is associated with high levels of morbidity through loss of digits or limbs. The aim of this study was to examine the salvage rate following severe frostbite injury. Frostbite patients from 2006 to 2014 were identified in the prospectively maintained database at a single urban burn and trauma center. Read More

    Percutaneous CT-Guided Cryoablation of the Salivary Glands in a Porcine Model.
    J Vasc Interv Radiol 2016 Dec 24;27(12):1907-1912. Epub 2016 Aug 24.
    Department of Diagnostic and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address:
    Purpose: To evaluate the imaging, histologic changes and safety of computed tomography (CT)-guided cryoablation of the parotid glands in a porcine model.

    Materials And Methods: Unilateral CT-guided parotid gland cryoablation was performed in 5 juvenile miniature pigs. The ablated parotid glands underwent 2 cycles of 10-minute freeze and 5-minute thaw using three 17-g cryoprobes. Read More

    Frostbite: Spectrum of Imaging Findings and Guidelines for Management.
    Radiographics 2016 Nov-Dec;36(7):2154-2169. Epub 2016 Aug 5.
    From the Division of Nuclear Medicine (J.D.M., R.K.J.B., M.D.G., K.K.W.) and Division of Musculoskeletal Radiology (J.A.J.), Department of Radiology, and Division of Plastic Surgery, Department of Surgery (B.L., C.T.K.), University of Michigan Health System, 1500 E Medical Center Dr, UH B1-D502, Ann Arbor, MI 48109.
    Frostbite is a localized cold thermal injury that results from tissue freezing. Frostbite injuries can have a substantial effect on long-term limb function and mobility if not promptly evaluated and treated. Imaging plays a critical role in initial evaluation of frostbite injuries and in monitoring response to treatment. Read More

    Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro.
    Evid Based Complement Alternat Med 2016 20;2016:3160247. Epub 2016 Jun 20.
    Department of Traditional Chinese Medicine, College of Medicine, Jinan University, Guangzhou 510630, China.
    Angelica sinensis has been used to attenuate cold-induced cutaneous vasospasm syndrome, such as Raynaud's disease and frostbite, in China for many years. Ferulic acid (PubChem CID: 445858) and Z-ligustilide (PubChem CID: 529865), two major components extracted from Angelica sinensis, had been reported to inhibit vasoconstriction induced by vasoconstrictors. In this study, the pharmacological interaction in regulating cold-induced vascular smooth muscle cell contraction via cold-sensing protein TRPM8 and TRPA1 was analyzed between ferulic acid and Z-ligustilide. Read More

    Pathophysiologic Determination of Frostbite Under High Altitude Environment Simulation in Sprague-Dawley Rats.
    Wilderness Environ Med 2016 Sep 7;27(3):355-63. Epub 2016 Jul 7.
    Department of Medical Engineering, Urumchi General Hospital of Lanzhou Military Region, Urumchi, China (Drs Geng, Jiao, Lou, and Jiao). Electronic address:
    Objectives: Pathophysiologic changes of frostbite have been postulated but rarely understood, especially the changes caused by chilly high altitude environment. Therefore, we investigated the pathophysiologic changes of high altitude frostbite (HAF) caused by cold and hypoxia.

    Methods: Forty Sprague-Dawley rats were randomly divided into 5 equal groups, namely, control, superficial HAF (S-HAF), partial-thickness HAF (PT-HAF), full-thickness HAF (FT-HAF), and partial-thickness normal frostbite (PT-NF) groups. Read More

    Catheter-Directed Intraarterial Thrombolysis as Part of a Multidisciplinary Management Protocol of Frostbite Injury.
    J Vasc Interv Radiol 2016 Aug 28;27(8):1228-35. Epub 2016 Jun 28.
    Division of Interventional Radiology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
    Purpose: To evaluate intraarterial catheter-directed thrombolysis for prediction and prevention of delayed surgical amputation as part of multidisciplinary management of frostbite injury.

    Materials And Methods: A retrospective review was performed of 13 patients (11 men, 2 women; median age, 33.4 y; range, 8-62 y) at risk of tissue loss secondary to frostbite injury and treated with catheter-directed tissue plasminogen activator (t-PA) thrombolysis. Read More

    SPECT/CT in the Evaluation of Frostbite.
    J Burn Care Res 2017 Jan/Feb;38(1):e227-e234
    From the *University of Michigan Medical School, Ann Arbor; †Department of Radiology, ‡Division of Plastic Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor; §Department of Surgery, ‖Charles B. G. de Nancrede Professor of Plastic Surgery, Division of Plastic Surgery, Department of Surgery, ¶Department of Radiology, and #Division of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor.
    Frostbite remains a challenging clinical scenario with multiple treatment algorithms and variable results. Currently, frostbite management often follows a conservative approach with rewarming followed by wound care and delayed amputation. We review seven patients where single-photon emission computed tomography (SPECT) fused with conventional computed tomography was used to evaluate tissue viability for earlier directed debridement and limb salvage. Read More

    Pneumodissection for skin protection in image-guided cryoablation of superficial musculoskeletal tumours.
    Eur Radiol 2017 Mar 10;27(3):1202-1210. Epub 2016 Jun 10.
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
    Purpose: Pneumodissection is described as a simple method for preventing skin injury during cryoablation of superficial musculoskeletal tumours.

    Methods: Superficial tumour cryoablations performed from 2009 to 2015 were retrospectively reviewed. Pneumodissection was performed in 13 patients when the shortest tumour-skin distance was less than 25 mm. Read More

    Percutaneous computed tomography-guided cryoablation for recurrent retroperitoneal soft tissue sarcoma: a study of safety and efficacy.
    Oncotarget 2016 Jul;7(27):42639-42649
    Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Aims: To evaluate the use of computed tomography image-guided percutaneous cryoablation for recurrent retroperitoneal soft tissue sarcomas (RPSs).

    Results: Adverse events were limited to grades 1 and 2, included fever (n = 19), local pain (n = 11), emesis (n = 10), frostbite (n = 6), and nerve injury (n = 1). Fever was more frequent in the large tumor group (15. Read More

    Results of a Prospective Observational Study on Mountaineering Emergencies in Western Alps: Mind Your Head.
    High Alt Med Biol 2016 Jun 23;17(2):116-21. Epub 2016 May 23.
    1 Department of Mountain Medicine, Aosta Regional Hospital , Aosta, Italy .
    Unlabelled: Brustia, Raffaele, Giulia Enrione, Bruna Catuzzo, Luca Cavoretto, Massimo Pesenti Compagnoni, Enrico Visetti, Emmanuel Cauchy, Stefanie Ziegler, and Guido Giardini. Results of a prospective observational study on mountaineering emergencies in Western Alps: mind your head. High Alt Med Biol. Read More

    Cold thermal injury from cold caps used for the prevention of chemotherapy-induced alopecia.
    Breast Cancer Res Treat 2016 Jun 5;157(2):395-400. Epub 2016 May 5.
    Dermatology Service, Memorial Sloan Kettering Cancer Center, 60th Street Outpatient Center, 16 East 60th St., Suite 407, Room 4312, New York, NY, USA.
    Introduction: The use of scalp cooling for the prevention of chemotherapy-induced alopecia (CIA) is increasing. Cold caps are placed onto the hair-bearing areas of the scalp for varying time periods before, during, and after cytotoxic chemotherapy. Although not yet reported, improper application procedures could result in adverse events (AEs). Read More

    North Pole Marathon Laboratory Lessons and Field Success.
    Aerosp Med Hum Perform 2016 May;87(5):493-7
    Background: This case study documents the training, laboratory preparation, and in-race performance data from Great Britain's top finisher in the 13(th) edition of the UVU North Pole Marathon.

    Case Report: We report data from a preparatory laboratory test in simulated cold conditions (-15°C) with and without wind chill during high- and low-intensity expected 'race pace' running. These tests examined the adequacy of the selected clothing assembly and provided recommendations for the race. Read More

    Chilblain-like leukaemia cutis.
    BMJ Case Rep 2016 Apr 19;2016:10.1136/bcr-2016-214838. Epub 2016 Apr 19.
    Pathology and Laboratory Medicine, University of Kansas School of Medicine, Kansas City, Kansas, USA.
    Chilblain, also known as pernio, is an abnormal inflammatory response to cold, moist environmental conditions. Persistent or atypical lesions should prompt investigation to exclude underlying systemic illness. We describe a case of acute myeloid leukaemia that presented with chilblain-like leukaemia cutis. Read More

    [Lumbar sympathectomy literature review over the past 15 years].
    Rozhl Chir 2016 Mar;95(3):101-6
    Introduction: Lumbar sympathectomy (LS) irreversibly damages a part of the sympathetic trunk and adjacent ganglia between L1 and L5, typically between L2 and L4. The first LS was performed in 1923. Initially, it used to be performed very often; however, with the progress of vascular and endovascular surgery its importance gradually continues to decline. Read More

    Management of Severe Frostbite in a Grey-Headed Parrot (Poicephalus fuscicollis suahelicus).
    J Avian Med Surg 2016 Mar;30(1):39-45
    An approximately 5-year-old female grey-headed parrot (Poicephalus fuscicollis suahelicus) was evaluated after exposure to outdoor temperatures below -20°C (-4°F) for approximately 22 hours. Severe frostbite affecting multiple digits, as well as dehydration and a depressed attitude, were diagnosed. Treatment included oral antibiotics, antifungals, nonsteroidal anti-inflammatories (NSAIDs), pentoxifylline, and topical aloe vera. Read More

    Bubbling cell death: A hot air balloon released from the nucleus in the cold.
    Exp Biol Med (Maywood) 2016 Jun 12;241(12):1306-15. Epub 2016 Apr 12.
    Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan 70101, Taiwan, ROC Department of Neuroscience and Physiology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA Department of Neurochemistry, NYS Institute of Basic Research for Developmental Disabilities, Staten Island, NY 10314, USA
    Cell death emanating from the nucleus is largely unknown. In our recent study, we determined that when temperature is lowered in the surrounding environment, apoptosis stops and bubbling cell death (BCD) occurs. The study concerns the severity of frostbite. Read More

    Full-thickness wounds resulting from 'do-it-yourself' cryolipolysis: a case study.
    J Wound Care 2016 Apr;25(4):S30-2
    Vanderbilt Burn Center Nashville, TN.
    This report reviews the case of a 55-year-old woman who suffered frostbite while attempting a 'do-it-yourself' version of cryolipolysis without the guidance of a medical professional. Cryolipolysis is a well-understood process through which the careful application of below-freezing temperatures is used to induce adipose cell death while sparing the skin, reducing body fat. This patient used dry ice in lieu of professional medical equipment, resulting in 4% total body surface area full- and partial-thickness wounds to her abdomen. Read More

    Treatment of severe frostbite with iloprost in northern Canada.
    CMAJ 2016 Dec 4;188(17-18):1255-1258. Epub 2016 Apr 4.
    Whitehorse General Hospital (Poole, Gauthier), Yukon Hospital Corporation, Whitehorse, Yukon; Department of Surgery (Poole), Cumming School of Medicine, University of Calgary, Calgary, Alta.; College of Pharmacy and Nutrition (Gauthier), University of Saskatchewan, Saskatoon, Sask.

    Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.
    Am J Addict 2016 Aug 1;25(5):358-69. Epub 2016 Apr 1.
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
    Background/objectives: Nitrous oxide (N2 O) is known to have abuse potential, although debate regarding the toxic effects of such abuse continues. Our objective was to review the case literature and present the neurologic, psychiatric and medical consequences of N2 O abuse.

    Methods: A systematic literature review was completed for case reports using keywords "nitrous oxide" with "abuse/abusing" or "misuse/misusing" or "overuse/overusing" or "addiction. Read More

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