2,745 results match your criteria Frostbite


Therapeutic potential of mesenchymal stromal cells for the treatment of frostbite injury.

Burns 2022 Jun 1. Epub 2022 Jun 1.

Moscow Institute of Physics and Technology (National Research University), Institutsky per. 9, Dolgoprudny, Moscow Region 141701 Russia. Electronic address:

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Effect of parental supervision of infants at age 4 to 6 months on injuries at age 4 to 12 months.

Sci Rep 2022 Jun 17;12(1):10252. Epub 2022 Jun 17.

Department of Pediatrics, School of Medicine, CHA Bundang Medical Center, CHA University, 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.

This study analyzed the effect of parental supervision of infants at age 4 to 6 months on injuries at age 4 to 12 months. Among all Korean children born during 2008-2009, 464,326 (50.6%) infant had parents who responded to a questionnaire that surveyed their safety and supervision when infant were 4 to 6 months-old. Read More

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Therapeutic potential of mesenchymal stromal cells for frostbite injury.

Burns 2022 May 28. Epub 2022 May 28.

Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China; Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China. Electronic address:

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Re: "A Photographic Case of Frostbite Treated with Delayed Hyperbaric Oxygen Therapy" by Davis et al.

High Alt Med Biol 2022 Jun;23(2):198-199

Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.

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COVID-19 cutaneous manifestations in children and adolescents: a systematic review.

Rev Paul Pediatr 2022 10;40:e2021134. Epub 2022 Jun 10.

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: The aim of this study was to evaluate the coronavirus disease 2019 (COVID-19) cutaneous manifestations described in pediatric patients and discuss their relevance for early diagnosis.

Data Source: The study consisted of a systematic review of original articles indexed in PubMed and Embase databases, as well as gray literature articles found through Google Scholar. A search strategy, based on PICO (Patient, Intervention, Comparison, Outcome) Tool, with the terms "child," "infant," "childhood," "adolescents," "teenagers," "COVID-19," "SARS-CoV-2," and "skin manifestations," was performed to optimize the findings. Read More

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Chilblain-like lesions onset during SARS-CoV-2 infection in a COVID-19-vaccinated adolescent: case report and review of literature.

Ital J Pediatr 2022 Jun 13;48(1):93. Epub 2022 Jun 13.

Department of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.

Background: COVID toes or chilblain-like skin lesions have been widely reported during COVID-19 pandemic. Most cases were described in patients with negative microbiological tests for SARS-CoV-2, therefore the possible relationship with SARS-CoV-2 infection, as well as with the nowadays broadly available mRNA-based vaccination, has not been fully elucidated.  CASE PRESENTATION: We here describe the case of a 14-year-old male who developed chilblain-like skin eruptions during SARS-CoV-2 infection despite two mRNA-based vaccine doses and review the clinical and epidemiological characteristics of chilblain-like lesions as a cutaneous presentation of COVID-19 in children. Read More

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Bilateral auriclar and external ear canal cartilage calcification.

Ear Nose Throat J 2022 Jun 11:1455613221103076. Epub 2022 Jun 11.

Department of Otolaryngology-Head and Neck Surgery, 65722Chonnam National University Medical School & Hwasun Hospital, Jeonnam, Korea.

Calcification of auricular cartilage is a rare condition. This phenomenon might be associated with frostbite, local trauma, inflammation, or systemic diseases. Calcification that progresses to the external ear canal cartilage is even rarer. Read More

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Diagnosis and Treatment of Frostbite.

N Engl J Med 2022 06;386(23):2213-2220

From the Departments of Surgery (R.L.S., J.M.G.) and Radiology (T.G.W.), Massachusetts General Hospital, and Boston Shriners Hospital for Children (R.L.S., J.M.G.) - both in Boston.

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Research on physicochemical properties, microscopic characterization and detection of different freezing-damaged corn seeds.

Food Chem X 2022 Jun 21;14:100338. Epub 2022 May 21.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.

Seed freezing damage is an agricultural disaster. To explore how frostbite affects the growth and development of corn seeds, the germination conditions, and the biological indicators including the activities of related enzymes (SOD, POD, CAT, and AMS) of different frozen corn seeds (normal, -10 °C,10 h, and -20 °C,10 h) were measured. The texture of seed coat and the cell structure of seed embryo were observed by scanning electron microscope and transmission electron microscope respectively. Read More

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B cell depletion therapy using rituximab to induce long-term remission of recalcitrant skin lesions of subacute cutaneous lupus erythematosus.

BMJ Case Rep 2022 May 27;15(5). Epub 2022 May 27.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India

A woman in her 20s presented with chilblains for 2 years and recent-onset photodistributed psoriasiform plaques. She did not have persistent good improvement despite treatment with 1 mg/kg oral prednisolone, along with successive trials with many steroid-sparing adjuvants in adequate dosage and duration, including hydroxychloroquine, methotrexate and cyclosporine, in the following 6 months. The patient had an excellent improvement and went into remission with two doses of injection rituximab, 1 g each, at a 2-week interval. Read More

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A review of construction workforce health challenges and strategies in extreme weather conditions.

Int J Occup Saf Ergon 2022 Jun 17:1-12. Epub 2022 Jun 17.

Department of Construction Management, East Carolina University, USA.

Construction sites continue to operate despite inclement weather, exposing workers to unpleasant working circumstances that can lead to various physical and mental health challenges. A thorough literature review yielded 21 challenges for hot weather conditions such as heat stroke, kidney disease, heat cramps, anxiety and depression, and 20 challenges for cold weather conditions like asthma, frostbite, musculoskeletal disorders and hallucination. Workers vulnerable to hot and cold weather based on demographic characteristics were identified. Read More

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Local injection of bone-marrow derived mesenchymal stromal cells alters a molecular expression profile of a contact frostbite injury wound and improves healing in a rat model.

Burns 2022 Apr 27. Epub 2022 Apr 27.

Moscow Institute of Physics and Technology (National Research University), Institutsky per. 9, Dolgoprudny, Moscow Region 141701, Russia. Electronic address:

Introduction: Frostbite is a traumatic injury of the tissues upon low temperature environment exposure, which is characterized by direct cell injury due to freezing-thawing followed by development of an acute inflammatory process. Severe frostbite can lead to necrosis of soft tissues and loss of a limb. Mesenchymal stromal cells (MSCs) have a unique ability to modulate pathogenic immune response by secretion of paracrine factors, which suppress inflammation and mediate more efficient tissue regeneration. Read More

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The role of hyperbaric oxygen for acute traumatic ischemias.

Undersea Hyperb Med 2022 Second Quarter;49(2):233-248

Memorial Care Long Beach Memorial Medical Center, Long Beach, California U.S.

Acute traumatic ischemias are an array of disorders that range from crush injuries to compartment syndromes, from burns to frostbite and from threatened flaps to compromised reimplantations. Two unifying components common to these conditions are a history of trauma be it physical, thermal, or surgical coupled with ischemia to the traumatized tissues. Their pathophysiology resolves around the self-perpetuating cycle of edema and ischemia, and their severity represents a spectrum from mild, almost non-existent, to tissue death. Read More

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Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China.

World J Pediatr 2022 Jul 12;18(7):490-497. Epub 2022 May 12.

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Aicardi-Goutieres syndrome (AGS) is an inflammatory disorder belonging to the type I interferonopathy group. The clinical diagnosis of AGS is difficult, which can lead to a high mortality rate. Overall, there is a lack of large-sample research data on AGS in China. Read More

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COVID-19 Vaccination Safety in Patients who have had SARS-CoV-2-induced Chilblains.

Acta Derm Venereol 2022 06 9;102:adv00728. Epub 2022 Jun 9.

Department of Dermatology, University Hospital Rennes, 2 rue Henri le Guilloux, FR-35000 Rennes, France.

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Postoperative outcomes for Nunavut Inuit at a Canadian quaternary care centre: a retrospective cohort study.

CMAJ Open 2022 Apr-Jun;10(2):E304-E312. Epub 2022 May 3.

Department of Anesthesiology and Pain Medicine (McVicar, Hoang-Nguyen, Poon, Bould, McIsaac), University of Ottawa; The Ottawa Hospital (McVicar, Hoang-Nguyen, Kimmaliardjuk, Poon, McIsaac); Children's Hospital of Eastern Ontario (Bould), Ottawa, Ont.; Department of Anaesthesia (O'Shea), Royal Darwin Hospital, Northern Territory, Australia; Department of Surgery (Kimmaliardjuk), University of Ottawa, Ottawa, Ont.; West Parry Sound Health Centre (Champion), Parry Sound, Ont.; Department of Surgery (Champion), Northern Ontario School of Medicine, Sudbury, Ont.; Qikiqtani General Hospital (Sheffield), Iqaluit, Nunavut; Nunavut Tunngavik Incorporated (Allen); Bruyère Research Institute (Nickerson); Centre for Health Law, Policy and Ethics (Nickerson), University of Ottawa, Ottawa, Ont.; Department of Surgery and Northern Medical Program (Caron), University of British Columbia, Prince George, BC; Centre for Excellence in Indigenous Health (Caron), University of British Columbia, Vancouver, BC.

Background: Structural aspects of health care systems, such as limited access to specialized surgical and perioperative care, can negatively affect the outcomes and resource use of patients undergoing elective and emergency surgical procedures. The aim of this study was to compare postoperative outcomes of Nunavut Inuit and non-Inuit patients at a Canadian quaternary care centre.

Methods: We conducted a retrospective cohort study involving adult (age ≥ 18 yr) patients undergoing inpatient surgery from 2011 to 2018 at The Ottawa Hospital, the quaternary referral hospital for the Qikiqtaaluk Region of Nunavut. Read More

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Review of our 10 years experience in cold burns at the burn center in the Southeast Anatolia region of Turkey.

Ulus Travma Acil Cerrahi Derg 2022 Mar;28(3):369-374

Department of General Surgery, Ankara City Hospital, Ankara-Turkey.

Background: Frostbite injuries remain to be one of the most complex and current problems of emergency medicine. Although cold burns are less frequent in hot climatic regions, it is a trauma, especially for men in our region. Also, most of the patients have difficulties in gaining early access to health and burn centers. Read More

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Plant-inspired conductive adhesive organohydrogel with extreme environmental tolerance as a wearable dressing for multifunctional sensors.

Colloids Surf B Biointerfaces 2022 Jul 19;215:112509. Epub 2022 Apr 19.

College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350108, PR China. Electronic address:

Conductive hydrogels have attracted significant attention as a promising material in electrical and biomedical fields. However, the simultaneous realization of good conductivity, toughness, high tissue adhesiveness, excellent biocompatibility, and extreme environmental tolerance remains a challenge. Inspired by the antifreezing/antiheating behavior of natural plants, a calcium chloride/TEMPO-oxidized cellulose nanofiber-dopamine/ polyacrylamide (CaCl/TOCNF-DOPA/PAM) glycerol/water organohydrogel with antifreezing and antiheating properties, good transparency, conductivity, stability, excellent biocompatibility, mechanical properties, and tissue adhesiveness was fabricated. Read More

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Successful Delayed Hyperbaric Oxygen Therapy and Iloprost Treatment on Severe Frostbite at High Altitude.

High Alt Med Biol 2022 Apr 21. Epub 2022 Apr 21.

Underwater and Hyperbaric Medicine Unit, Acute Medicine Department, University Hospital of Geneva, Geneva, Switzerland.

Magnan, Dre Marie-Anne, Marco Gelsomino, Pierre Louge, and Rodrigue Pignel. Successful delayed hyperbaric oxygen therapy and iloprost treatment on severe frostbite at high altitude. 00:000-000, 2022. Read More

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Design and optimization of a novel herbosomal-loaded PEG-poloxamer topical formulation for the treatment of cold injuries: a quality-by-design approach.

Drug Deliv Transl Res 2022 Apr 21. Epub 2022 Apr 21.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi, India.

The spectrum of cold injuries ranges from frostnip, chilblains to severe frostbite. Cold injuries occur upon prolonged exposure to freezing temperature and are pathologically a combination of ice crystal formation in the tissue resulting in inflammation, thrombosis and ischemia in the extremities, often necessitating limb amputation in extreme cases due to tissue necrosis. Severe forms of frostbite are a cause of major concern to patients as well as the treating physician. Read More

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Cold Weather Injuries: Initial Evaluation and Management.

Curr Sports Med Rep 2022 Apr;21(4):117-122

Department of Family Medicine, Uniformed Services University, Bethesda, MD.

Abstract: As more people take to extreme sporting activities and hobbies, the sports medicine physician should be proficient in early identification and initial sideline or field management of cold weather injuries. There is significant mortality and morbidity associated with these conditions. The most severe of these are hypothermia and frostbite, which have limited evidence for their field management. Read More

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Frostbite of the upper extremities: Hot issues in diagnosis and surgical treatment (review).

Burns 2022 Mar 17. Epub 2022 Mar 17.

Institute of Clinical Medicine named after N.V. Sklifosovsky, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. Electronic address:

Background: Frostbite is a severe thermal injury, which characterized by tissue necrosis with a high percentage of amputations, disability of patients.

Methods: According to the databases Web of Science, Google Scholar, PubMed, E-library down to 2001-2021 the search for works related to the problem of diagnosis, treatment of frostbite of the upper extremities was made. Actual possibilities of diagnostics, the questions of classification, treatment of frostbite, including the features of plastic surgery operations used to close hand defects after excision of necrotic tissues have been analyzed. Read More

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Pandemic chilblains: Are they SARS-CoV-2-related or not?

Clin Immunol 2022 04 23;237:108984. Epub 2022 Mar 23.

Division of Dermatology, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

The exact etiopathology of chilblains observed during the Coronavirus Disease 2019 (COVID-19) pandemic is still unclear. Initially, SARS-CoV-2 appeared as the obvious causing agent, but two years of various investigations have failed to convincingly support its direct implication. Most affected individuals have no detectable virus, no anti-SARS-CoV-2 antibodies and no symptoms of COVID-19. Read More

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Chilblain-like acral lesions.

Eur J Intern Med 2022 Jun 22;100:119-120. Epub 2022 Mar 22.

Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

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'Home-school toes' - a case series of paediatric perniosis presentations.

Australas J Dermatol 2022 05 22;63(2):256-258. Epub 2022 Mar 22.

Faculty of Medicine & Health, University of New South Wales, Kensington, New South Wales, Australia.

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Hypoxia-induced nuclear translocation of β-catenin in the healing process of frostbite.

Biochim Biophys Acta Mol Basis Dis 2022 06 12;1868(6):166385. Epub 2022 Mar 12.

Forensic Medicine Laboratory, Department of Oncology-Pathology, Karolinska Institute, Sweden.

Frostbite occurs when the skin is exposed to localized low temperatures. The main causes of frostbite are thought to be direct cell injury due to freezing of cells and tissue ischemia due to abnormal blood circulation. However, the molecular mechanism of frostbite has not been elucidated. Read More

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Abstracts from The Cold Weather Operations Conference 2021.

Int J Circumpolar Health 2022 12;81(1):2049491

Institute of Community Medicine, UiT - the Arctic University of Norway, Tromsø, Norway.

A common effort for both military and civil healthcare is to achieve knowledge-based health care in cold weather injuries and fatal accidents in harsh arctic environment. The in November 2021, having more than 300 participants from 20 countries, was addressing the prevention and treatment of injuries and trauma care in cold weather conditions and the challenges for military prehospital casualty care. The intention of the programme was to stimulate further research and systematic knowledge-based clinical work. Read More

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December 2022

Cutaneous sarcoidosis: Lupus pernio and more.

Ital J Dermatol Venerol 2022 Jun 11;157(3):220-227. Epub 2022 Mar 11.

Rutgers-New Jersey Medical School, Newark, NJ, USA -

Sarcoidosis is a multiorgan disease commonly evident with skin involvement. Cutaneous manifestations occur in about 25% of sarcoid patients and are of two types: histologically specific sarcoidal infiltrations and a cutaneous reaction pattern not containing sarcoidal changes, usually erythema nodosum. Cutaneous plaques, nodules, and tumors, sometimes with disfiguring facial features are associated with pain and paresthesia. Read More

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