556 results match your criteria Frontiers of medicine[Journal]


High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells.

Front Med 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Read More

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http://link.springer.com/10.1007/s11684-018-0677-1
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http://dx.doi.org/10.1007/s11684-018-0677-1DOI Listing
February 2019
7 Reads

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy.

Front Med 2019 Feb 5. Epub 2019 Feb 5.

National Translational Science Center for Molecular Medicine, Xi'an, 710032, China.

Lung cancer is the most common incident cancer and the leading cause of cancer death. In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-T) cell has shown a promising future. Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancer with a mutation rate of 10%. Read More

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http://dx.doi.org/10.1007/s11684-019-0683-yDOI Listing
February 2019
1 Read

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma.

Front Med 2019 Jan 31. Epub 2019 Jan 31.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). Read More

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http://dx.doi.org/10.1007/s11684-019-0680-1DOI Listing
January 2019
1 Read

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy.

Front Med 2019 Jan 24. Epub 2019 Jan 24.

ShangHai Cell Therapy Group Co., Ltd., Shanghai, 201805, China.

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Read More

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http://link.springer.com/10.1007/s11684-018-0678-0
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January 2019
11 Reads

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation.

Front Med 2019 Jan 24. Epub 2019 Jan 24.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, 100044, China.

The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon-α (IFN- α) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRDpositive after allogeneic hematopoietic stem cell transplantation (allo-HSCT). High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology and were MRD-positive after allo-HSCT were studied (n = 47). The MRD-positive status was considered if leukemia-associated aberrant immune phenotypes orWilms' tumor gene 1 expression is present in a single bone marrow sample. Read More

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http://dx.doi.org/10.1007/s11684-018-0665-5DOI Listing
January 2019
1 Read

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12.

Front Med 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.

Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%-85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Read More

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http://dx.doi.org/10.1007/s11684-019-0682-zDOI Listing
January 2019

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases.

Front Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpoint proteins, and molecular subtypes of cancers. Read More

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http://dx.doi.org/10.1007/s11684-019-0679-7DOI Listing
January 2019
1 Read

Adoptive cell transfer therapy for hepatocellular carcinoma.

Front Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Cell Biology, National Translational Science Center for Molecular Medicine, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, 710032, China.

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. Read More

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January 2019
6 Reads

Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloid leukemia.

Front Med 2019 Jan 12. Epub 2019 Jan 12.

Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology and Oncology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Homoharringtonine (HHT), a plant alkaloid from Cephalotaxus harringtonia, exhibits a unique anticancer mechanism and has been widely used in China to treat patients with acute myeloid leukemia (AML) since the 1970s. Trial SCMC-AML-2009 presented herein was a randomized clinical study designed based on our previous findings that pediatric AML patients younger than two years old may benefit from HHT-containing chemotherapy regimens. Patients randomized to arm A were treated with a standard chemotherapy regimen comprising mainly of anthracyclines and cytarabine (Ara-C), whereas patients in arm B were treated with HHT-containing regimens in which anthracyclines in all but the initial induction therapy were replaced by HHT. Read More

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http://link.springer.com/10.1007/s11684-018-0658-4
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January 2019
7 Reads

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis.

Front Med 2019 Jan 12. Epub 2019 Jan 12.

Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, the Second Military Medical University, Shanghai, 200003, China.

Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes associated with RA.We then systematically review various factors that have a predictive value (predictors) for the response to different drugs in RA treatment, especially recent advances. Read More

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http://link.springer.com/10.1007/s11684-018-0659-3
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January 2019
4 Reads

Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice.

Front Med 2019 Jan 2. Epub 2019 Jan 2.

Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. Read More

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http://dx.doi.org/10.1007/s11684-018-0649-5DOI Listing
January 2019
2 Reads

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy: China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study.

Front Med 2019 Jan 2. Epub 2019 Jan 2.

Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University Institute of Hematology, Peking University, People's Hospital, Beijing, 100044, China.

Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies. In this study, we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n = 3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression, which included the following variables: male patients, induction chemotherapy for newly diagnosed or relapsed disease, neutropenia, neutropenia longer than 10 days, hypoalbuminemia, central-venous catheter, and history of IFD. The patients were classified into three groups, which had low (0-10, ~1. Read More

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http://dx.doi.org/10.1007/s11684-018-0641-0DOI Listing
January 2019
2 Reads

BRD4 interacts with PML/RARα in acute promyelocytic leukemia.

Front Med 2018 Dec 14;12(6):726-734. Epub 2018 Dec 14.

State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for cancer therapy. This protein can be targeted by JQ1, a selective small-molecule inhibitor. However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent. Read More

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http://dx.doi.org/10.1007/s11684-017-0604-xDOI Listing
December 2018
2 Reads

Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea.

Front Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in Korea. We compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate (GFR). We extracted data of patients who took statin for the first time. Read More

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http://dx.doi.org/10.1007/s11684-018-0661-9DOI Listing
November 2018
1 Read

Calorie restriction and its impact on gut microbial composition and global metabolism.

Front Med 2018 Dec 16;12(6):634-644. Epub 2018 Nov 16.

Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and prevents the development of metabolic and age-related diseases. In the present review, we focus on the general effect of CR on gut microbiota composition and global metabolism. Read More

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http://link.springer.com/10.1007/s11684-018-0670-8
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December 2018
11 Reads

Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis.

Front Med 2018 Dec 16;12(6):678-687. Epub 2018 Nov 16.

State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Type 2 diabetes (T2D) has been associated with a high prevalence of depression.We aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2D risk genetic variants validated in East Asians as the instrumental variable (IV). An MR analysis was performed involving 11 506 participants from a large longitudinal study. Read More

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http://link.springer.com/10.1007/s11684-018-0671-7
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http://dx.doi.org/10.1007/s11684-018-0671-7DOI Listing
December 2018
8 Reads

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway.

Front Med 2018 Dec 13;12(6):697-706. Epub 2018 Nov 13.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. Read More

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http://link.springer.com/10.1007/s11684-018-0655-7
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December 2018
17 Reads

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice.

Front Med 2018 Dec 13;12(6):688-696. Epub 2018 Nov 13.

Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co., Ltd., Tianjin, 300410, China.

Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms against hyperglycemia remain poorly understood. This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy mice model. Read More

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December 2018
16 Reads

Interplay between diet and genetic susceptibility in obesity and related traits.

Front Med 2018 Dec 9;12(6):601-607. Epub 2018 Nov 9.

State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. Read More

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http://link.springer.com/10.1007/s11684-018-0648-6
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December 2018
11 Reads

Analyzing the distinguishing factors that affect childhood obesity in South Korea.

Front Med 2018 Dec 9;12(6):707-716. Epub 2018 Nov 9.

Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Understanding obesity in children is crucial because it can lead to adulthood obesity and result in fatal chronic diseases. Distinctive factors associated with obesity in adults have been described, but distinctive factors related to children remain unclear. We analyzed the correlation between the percentage of body mass index and lifestyle habits by conducting surveys on physical, nutritional, and psychological factors, and we used annual physical examination data to compare different traits among elementary school students (n = 197) and middle school students (n = 461). Read More

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http://link.springer.com/10.1007/s11684-018-0660-x
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December 2018
10 Reads

Early-onset diabetes: an epidemic in China.

Front Med 2018 Dec 5;12(6):624-633. Epub 2018 Nov 5.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai, 200233, China.

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Read More

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http://link.springer.com/10.1007/s11684-018-0669-1
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December 2018
9 Reads

Hybrid polymer biomaterials for bone tissue regeneration.

Front Med 2018 Oct 30. Epub 2018 Oct 30.

Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. Read More

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http://link.springer.com/10.1007/s11684-018-0664-6
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October 2018
2 Reads

Bile acids and their effects on diabetes.

Front Med 2018 Dec 10;12(6):608-623. Epub 2018 Oct 10.

University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.

Diabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, "metabolic memory," a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Read More

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December 2018
14 Reads

Epidemic obesity in children and adolescents: risk factors and prevention.

Front Med 2018 Dec 2;12(6):658-666. Epub 2018 Oct 2.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.

The prevalence of obesity among children and adolescents (aged 2-18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Read More

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http://dx.doi.org/10.1007/s11684-018-0640-1DOI Listing
December 2018
2 Reads

Histone variants: critical determinants in tumour heterogeneity.

Front Med 2018 Oct 2. Epub 2018 Oct 2.

Institute for Advanced Biosciences, CNRS UMR 5309, Inserm, U1209, University of Grenoble Alpes, 38706, Grenoble, France.

Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Read More

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http://link.springer.com/10.1007/s11684-018-0667-3
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October 2018
5 Reads

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia.

Front Med 2018 Sep 11. Epub 2018 Sep 11.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Collaboration of c-KIT mutations with AML1-ETO (AE) has been demonstrated to induce t(8; 21) acute myeloid leukemia (AML). Targeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AML. Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AML cell apoptosis and AE cleavage. Read More

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http://dx.doi.org/10.1007/s11684-018-0624-1DOI Listing
September 2018
22 Reads

Changes in public trust in physicians: empirical evidence from China.

Front Med 2018 Sep 7. Epub 2018 Sep 7.

School of Public Health, Shanghai Jiao Tong University, Shanghai, 200025, China.

Studies examining the trends in public trust in physicians have provided a considerable amount of valuable policy implications for policymakers compared with cross-sectional studies on this topic in many countries. This study investigated changes in public trust in physicians in China based on two cross-sectional national surveys conducted in 2011 and 2016 and identified the determinants of these changes. The results indicated 83. Read More

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http://dx.doi.org/10.1007/s11684-018-0666-4DOI Listing
September 2018
1 Read

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota.

Front Med 2018 Dec 4;12(6):645-657. Epub 2018 Sep 4.

Functional Metabolomic and Gut Microbiome Laboratory, Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in the context of obesity worldwide, which contains a spectrum of chronic liver diseases, including hepatic steatosis, non-alcoholic steatohepatitis and hepatic carcinoma. In addition to the classical "Two-hit" theory, NAFLD has been recognized as a typical gut microbiota-related disease because of the intricate role of gut microbiota in maintaining human health and disease formation. Moreover, gut microbiota is even regarded as a "metabolic organ" that play complementary roles to that of liver in many aspects. Read More

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December 2018
20 Reads

Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury.

Authors:
Bin Yu Xiaosong Gu

Front Med 2018 Aug 30. Epub 2018 Aug 30.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.

The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowing axons to follow, and, often by combining stem cell transplantation, to enable the local environment in the growth-supportive direction. Manipulations, such as the modulation of PTEN/mTOR pathways, can also enhance intrinsic CNS axon regrowth after injury. Read More

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http://dx.doi.org/10.1007/s11684-018-0642-zDOI Listing
August 2018
2 Reads

Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving dasatinib: efficacy and safety.

Front Med 2018 Aug 30. Epub 2018 Aug 30.

The Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300020, China.

Dasatinib is a highly effective second-generation tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML). In 2007, a pivotal phase-2 study of dasatinib as second-line treatment was initiated in 140 Chinese CML patients. This report from the 4-year follow-up revealed that 73% of 59 patients in chronic phase (CML-CP) and 32% of 25 patients in accelerated phase (CML-AP) remained under treatment. Read More

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http://dx.doi.org/10.1007/s11684-018-0639-7DOI Listing
August 2018
24 Reads

Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice.

Front Med 2018 Aug 30. Epub 2018 Aug 30.

School of Life Science, Shandong University, Jinan, 250100, China.

Tprn encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia in the inner ear. In humans, TPRN mutations cause autosomal recessive nonsyndromic deafness (DFNB79) by an unknown mechanism. To determine the role of Tprn in hearing, we generated Tprn-null mice by clustered regularly interspaced short palindromic repeat/Cas9 genome-editing technology from a CBA/CaJ background. Read More

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August 2018
12 Reads

Regulation of T cell immunity by cellular metabolism.

Front Med 2018 Aug 16;12(4):463-472. Epub 2018 Aug 16.

Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. Read More

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http://dx.doi.org/10.1007/s11684-018-0668-2DOI Listing
August 2018
1 Read

Complex interplay between tumor microenvironment and cancer therapy.

Front Med 2018 Aug 10;12(4):426-439. Epub 2018 Aug 10.

Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression has been well recognized. A growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses. Read More

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http://dx.doi.org/10.1007/s11684-018-0663-7DOI Listing
August 2018
1 Read

RNA mA modification and its function in diseases.

Front Med 2018 Aug 10;12(4):481-489. Epub 2018 Aug 10.

Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.

N-methyladenosine (mA) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. mA modification could be installed by mA "writers" composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by mA "erasers" (FTO and ALKBH5). The function of mA is executed by mA "readers" that bind to mA directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). Read More

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http://dx.doi.org/10.1007/s11684-018-0654-8DOI Listing
August 2018
16 Reads

Classification and treatment of orbital venous malformations: an updated review.

Front Med 2018 Aug 10. Epub 2018 Aug 10.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angiogenesis, hemodynamics, and locations. Read More

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http://dx.doi.org/10.1007/s11684-018-0623-2DOI Listing
August 2018
13 Reads

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model.

Front Med 2018 Aug 10. Epub 2018 Aug 10.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, 100853, China.

This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Read More

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http://dx.doi.org/10.1007/s11684-018-0620-5DOI Listing
August 2018
2 Reads

Cytokines and inflammation in adipogenesis: an updated review.

Front Med 2018 Aug 1. Epub 2018 Aug 1.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100730, China.

The biological relevance of cytokines is known for more than 20 years. Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g. Read More

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http://dx.doi.org/10.1007/s11684-018-0625-0DOI Listing
August 2018
27 Reads

Activation of phagocytosis by immune checkpoint blockade.

Front Med 2018 Aug 30;12(4):473-480. Epub 2018 Jul 30.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential inhibitory receptors that possess new functions beyond T cell exhaustion in this review. Read More

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http://dx.doi.org/10.1007/s11684-018-0657-5DOI Listing
August 2018
17 Reads

Mesenchymal stem cells and immune disorders: from basic science to clinical transition.

Front Med 2018 Jul 30. Epub 2018 Jul 30.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China.

As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i. Read More

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http://dx.doi.org/10.1007/s11684-018-0627-yDOI Listing
July 2018
5 Reads

Deubiquitinases as pivotal regulators of T cell functions.

Front Med 2018 Aug 27;12(4):451-462. Epub 2018 Jul 27.

Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, TX, 77030, USA.

T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-tissues. Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activation contributes to the pathogenesis of diverse autoimmune and inflammatory diseases. An emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversible process of protein modification that is counter-regulated by ubiquitinating enzymes and deubiquitinases (DUBs). Read More

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http://dx.doi.org/10.1007/s11684-018-0651-yDOI Listing
August 2018
2 Reads

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis.

Front Med 2018 Aug 27;12(4):412-425. Epub 2018 Jul 27.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 90109, USA.

Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-family of related basic-helix-loop-helix-zipper (bHLHZ) proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Read More

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http://dx.doi.org/10.1007/s11684-018-0650-zDOI Listing
August 2018
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Current advances for bone regeneration based on tissue engineering strategies.

Front Med 2018 Jul 25. Epub 2018 Jul 25.

Institute of Traumatology and Orthopaedics, Beijing Laboratory of Biomedical Materials, Beijing Jishuitan Hospital, Beijing, 100035, China.

Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Read More

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http://dx.doi.org/10.1007/s11684-018-0629-9DOI Listing
July 2018
5 Reads

Challenges of NK cell-based immunotherapy in the new era.

Front Med 2018 Aug 25;12(4):440-450. Epub 2018 Jul 25.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cell lines, have been used for producing NK cells. In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did not. Read More

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http://dx.doi.org/10.1007/s11684-018-0653-9DOI Listing
August 2018
9 Reads

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.

Front Med 2018 Aug 24;12(4):374-386. Epub 2018 Jul 24.

Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA.

A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt's lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. Read More

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http://dx.doi.org/10.1007/s11684-018-0652-xDOI Listing
August 2018
12 Reads

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities.

Front Med 2018 Aug 24;12(4):361-373. Epub 2018 Jul 24.

Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Read More

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http://dx.doi.org/10.1007/s11684-018-0656-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186394PMC
August 2018
1 Read

Intracellular and extracellular TGF-β signaling in cancer: some recent topics.

Front Med 2018 Aug 24;12(4):387-411. Epub 2018 Jul 24.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Read More

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http://dx.doi.org/10.1007/s11684-018-0646-8DOI Listing
August 2018
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Taking advantage of drug resistance, a new approach in the war on cancer.

Front Med 2018 Aug 18;12(4):490-495. Epub 2018 Jul 18.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. Read More

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http://link.springer.com/10.1007/s11684-018-0647-7
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http://dx.doi.org/10.1007/s11684-018-0647-7DOI Listing
August 2018
2 Reads

ECRG4: a new potential target in precision medicine.

Authors:
Xin Qin Ping Zhang

Front Med 2018 Jul 12. Epub 2018 Jul 12.

State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, 710032, China.

Given the rapid development in precision medicine, tremendous efforts have been devoted to discovering new biomarkers for disease diagnosis and treatment. Esophageal cancer-related gene-4 (ECRG4), which is initially known as a new candidate tumor suppressor gene, is emerging as a sentinel molecule for gauging tissue homeostasis. ECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expression pattern. Read More

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http://dx.doi.org/10.1007/s11684-018-0637-9DOI Listing
July 2018
13 Reads

HLA and lung transplantation.

Front Med 2018 Jul 5. Epub 2018 Jul 5.

HLA et Medecine, "Jean Dausset" Laboratory Network, Hôpital Saint-Louis, Paris, France.

Lung transplantation is increasingly practiced for patients with end-stage lung disease. The successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies, mainly directed against the protein products of the HLA complex of the organ donor. While the association between antibody mediated rejection and allograft damage has been well established in renal and heart transplantation, it has not yet been well characterized in lung transplantation. Read More

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http://dx.doi.org/10.1007/s11684-018-0636-xDOI Listing
July 2018
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Dental stem cell and dental tissue regeneration.

Front Med 2018 Jul 4. Epub 2018 Jul 4.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China.

The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Read More

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http://dx.doi.org/10.1007/s11684-018-0628-xDOI Listing
July 2018
2 Reads