6,933 results match your criteria Frontiers of medicine[Journal]
Evol Anthropol 2018 Dec 12. Epub 2018 Dec 12.
School of Sport, Exercise & Health Sciences, Loughborough University, Loughborough, United Kingdom.
BMC Infect Dis 2018 Dec 14;18(1):657. Epub 2018 Dec 14.
MSF, Geneva, Switzerland.
Background: In Southeast Asia, though fishermen are known to be a key population at high risk of HIV, little is known about their co-infection rates with Hepatitis C virus (HCV), or how illness and risk behaviors vary by occupation or type of fishermen. In Myanmar, this lack of knowledge is particularly acute, despite the fact that much of the country's border is coastline.
Methods: We conducted a retrospective analysis to assess clinical, demographic, and risk characteristics of HIV-infected, ≥15-year-old males under HIV care from 2004 to 2014. Read More
BMC Plant Biol 2018 Dec 12;18(1):349. Epub 2018 Dec 12.
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB-UNL), Av. da República, 2780-157, Oeiras, Portugal.
Background: SUMOylation is an essential eukaryotic post-translation modification that, in plants, regulates numerous cellular processes, ranging from seed development to stress response. Using rice as a model crop plant, we searched for potential regulatory points that may influence the activity of the rice SUMOylation machinery genes.
Results: We analyzed the presence of putative cis-acting regulatory elements (CREs) within the promoter regions of the rice SUMOylation machinery genes and found CREs related to different cellular processes, including hormone signaling. Read More
Elife 2018 Dec 7;7. Epub 2018 Dec 7.
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
The three-dimensional organization of DNA is increasingly understood to play a decisive role in vital cellular processes. Many studies focus on the role of DNA-packaging proteins, crowding, and confinement in arranging chromatin, but structural information might also be directly encoded in bare DNA itself. Here we visualize plectonemes (extended intertwined DNA structures formed upon supercoiling) on individual DNA molecules. Read More
JACC Cardiovasc Imaging 2018 Dec;11(12):1854-1878
Department of Medicine, University of Chicago Medical Center, Chicago, Illinois.
The ongoing refinements in 3-dimensional (3D) echocardiography technology continue to expand the scope of this imaging modality in clinical cardiology by offering new features that stem from the ability to image the heart in its complete dimensionality. Over the years, countless publications have described these benefits and tested new frontiers where 3D echocardiographic imaging seemed to offer promising ways to improve patients' care. These include improved techniques for chamber quantification and novel ways to visualize cardiac valves, including 3D printing, virtual reality, and holography. Read More
Cancer Manag Res 2018 21;10:6039-6047. Epub 2018 Nov 21.
Department of Respiratory Medicine, Kitasato University School of Medicine, Kanagawa, Japan,
Background: Small cell lung cancer (SCLC) is typically categorized according to disease extent as limited or extensive, and utility of the 8th TNM classification, recommended for lung cancer staging, which demonstrates a strong association with non-small-cell lung cancer (NSCLC) management, remains unclear.
Methods: This retrospective study included 277 consecutive SCLC patients treated at a single institution between 2008 and 2016.
Results: According to the currently used two-stage system, 186 (65. Read More
Proc Natl Acad Sci U S A 2018 Dec;115(50):12630-12637
Department of Sociology, University of Chicago, Chicago, IL 60637;
Rapid research progress in science and technology (S&T) and continuously shifting workforce needs exert pressure on each other and on the educational and training systems that link them. Higher education institutions aim to equip new generations of students with skills and expertise relevant to workforce participation for decades to come, but their offerings sometimes misalign with commercial needs and new techniques forged at the frontiers of research. Here, we analyze and visualize the dynamic skill (mis-)alignment between academic push, industry pull, and educational offerings, paying special attention to the rapidly emerging areas of data science and data engineering (DS/DE). Read More
Genomics Proteomics Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Dev Biol 2018 Dec 3. Epub 2018 Dec 3.
Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido 001-0020, Japan.
Eggs have developed their own strategies for early development. Amphibian, teleost fish, and ascidian eggs show cortical rotation and an accompanying structure, a cortical parallel microtubule (MT) array, during the one-cell embryonic stage. Cortical rotation is thought to relocate maternal deposits to a certain compartment of the egg and to polarize the embryo. Read More
Endosc Int Open 2018 Dec 29;6(12):E1413-E1416. Epub 2018 Nov 29.
Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
A gastric bezoar is a mass that forms in the stomach. A giant gastric bezoar is particularly difficult to treat medically, and surgical therapy is selected. We describe our experience with a patient who had a giant gastric trichobezoar that was extracted by laparoscopic and endoscopic cooperative surgery (LECS) in accordance with the principles of LECS. Read More
Persoonia 2018 Dec 18;40:i-iii. Epub 2018 May 18.
Forestry and Agricultural Biotechnology Institute (FABI), University of Pretoria, Pretoria, 0002, South Africa.
J Control Release 2018 Nov 29;293:144-154. Epub 2018 Nov 29.
Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
The last two decades have seen the development of acoustically activated droplets, also known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through bubble effects and triggered drug release, these superheated agents have found potential applications from oncology to neuromodulation. The aim of this review is to summarise the key developments in therapeutic droplet design and use, to discuss the current challenges slowing clinical translation, and to highlight the new frontiers progressing towards clinical implementation. Read More
Cad Saude Publica 2018 Nov 29;34(12):e00012818. Epub 2018 Nov 29.
Universidade Regional de Blumenau, Blumenau, Brasil.
Brazil currently has the highest absolute number of homicides in the world, which results from a complex range of factors. This study aimed at understanding the associations between socio-environmental determinants of health (SDH) and homicides in Brazil through a systematic literature review. The review followed PRISMA guidelines, selecting quantitative and qualitative studies published in Portuguese, English, and Spanish carried out between 2002 and 2017, available in the PubMed, MEDLINE, LILACS, SciELO and BVS-BIREME databases. Read More
Mol Reprod Dev 2018 Dec 5. Epub 2018 Dec 5.
Frontiers in Reproduction; Marine Biological Laboratories, University of Chicago, Woods Hole, MA.
One of the first steps towards a successful pregnancy is fertilization, where sperm and oocyte come together to form a zygote. In mammals, this process can occur in vitro, allowing assisted reproductive technologies (ART) to alleviate certain infertilities. ART - which includes in vitro fertilization and gamete donation - accounted for 1. Read More
Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.
Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
The prostate-specific membrane antigen (PSMA) is highly expressed in prostatic cancer. However, PSMA expression is also noted in various benign and malignant nonprostatic neoplasms in the endothelial cells of tumor-associated neovasculature. We performed Ga-PSMA PET/CT in a 14-year-old boy with juvenile nasal angiofibroma (JNA) to explore its theranostic potential. Read More
iScience 2018 Nov 20;10:98-113. Epub 2018 Nov 20.
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.
Extracellular signal-regulated kinase (ERK) plays critical roles in T cell development in the thymus. Nevertheless, the dynamics of ERK activity and the role of ERK in regulating thymocyte motility remain largely unknown due to technical limitations. To visualize ERK activity in thymocytes, we here developed knockin reporter mice expressing a Förster/fluorescence resonance energy transfer (FRET)-based biosensor for ERK from the ROSA26 locus. Read More
Food Technol Biotechnol 2018 Sep;56(3):398-410
San Pablo Tucumán University, Av. Solano Vera and Villa Nougués, T4129XAK, Tucumán, Argentina.
Lactic acid bacteria (LAB) improve the organoleptic, nutritional and physicochemical properties of artisanal foods. In this study, we selected 31 fermented dairy and vegetable foods marketed in Tucumán city, Argentina, as sources of LAB for the production of pickles. Sixty-four isolates presumptively identified as strains were screened for relevant technological properties for production of fermented foods. Read More
Arch Pathol Lab Med 2018 Dec;142(12):1457-1458
From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Hui); and the Department of Pathology, Princeton Medical Center, Plainsboro, New Jersey; the Department of Biological Sciences, Rutgers University, Newark, New Jersey; the Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, New Jersey; and Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey (Dr Zhang).
Nanoscale 2018 Dec;10(48):22673-22700
Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche (ISMAC-CNR), 20133 Milano, Italy.
Self-assembly offers a unique resource for the preparation of discrete structures at the nano- and microscale, which are either not accessible by other fabrication techniques or require highly expensive and technologically demanding processes. The possibility of obtaining spontaneous organization of separated components, whether they are molecules, polymers, nano- or micro-objects, into a larger functional unit, enables the development of ready-to-use plug and play devices and components at lower costs. Expanding the applicability of self-assembly approaches at the nanoscale to non-conventional substrates would open up new avenues towards multifunctional platforms customized for specific applications. Read More
Front Bioeng Biotechnol 2018 14;6:170. Epub 2018 Nov 14.
Texas Materials Institute, The University of Texas at Austin, Austin, TX, United States.
The field of medical micro/nanorobotics holds considerable promise for advancing medical diagnosis and treatment due to their unique ability to move and perform complex task at small scales. Nevertheless, the grand challenge of the field remains in its successful translation towards widespread patient use. We critically address the frontiers of the current methodologies for applications and discuss the current and foreseeable perspectives of their commercialization. Read More
ChemSusChem 2018 Nov 28. Epub 2018 Nov 28.
Abstract: Sustainable future extremely demands the innovative breakthroughs in science and technology today especially in the energy sector. Earth-abundant resources can be explored and used to develop renewable and sustainable resources of energy to meet, PAKISTAN.
Sustainable future extremely demands the innovative breakthroughs in science and technology today especially in the energy sector. Earth-abundant resources can be explored and used to develop renewable and sustainable resources of energy to meet the ever increasing global energy demand. The efficient solar-powered conversion systems with the exploitation of cheap and robust catalytic materials for the photo and photo-electro-induced water splitting, photovoltaic cell, fuel cell and renovation of waste products (such as CO2) as chemical fuel are appealing solutions in this quest. Read More
Clin Cancer Res 2018 Nov 27. Epub 2018 Nov 27.
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
Purpose: Sentinel lymph node biopsy (SLNB) is the gold-standard procedure for evaluating axillary lymph node (ALN) status in patients with breast cancer. However, the morbidity of SLNB is not negligible, and the procedure is invasive for patients without ALN metastasis. Here, we developed a diagnostic model for evaluating ALN status using a combination of serum microRNAs (miRNAs) and clinicopathological factors as a novel less-invasive biomarker. Read More
Chem Asian J 2018 Dec 27;13(23):3556-3560. Epub 2018 Nov 27.
Max Planck Institute for Polymer Research, Mainz, 55128, Germany.
Bilateral Symposium: The Technical University, Institute for Advanced Studies, hosted the 7th Sino-German Frontiers of Chemistry Symposium from September 2 to September 6, 2018. This event, co-organized by the Chinese Chemical Society (CCS) and the Gesellschaft Deutscher Chemiker (German Chemical Society), featured excellent talks by the invited early-career chemists of both countries and offered ample opportunities for discussions and making friends among the participants. Read More
Phys Life Rev 2018 11 28;26-27:96-99. Epub 2018 Jun 28.
Division of Applied Mathematics, Brown University, 170 Hope Street, Providence, RI 02906, United States of America. Electronic address:
Drug Deliv 2018 Nov;25(1):1865-1876
b State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Read More
Macromol Rapid Commun 2018 Nov 23:e1800650. Epub 2018 Nov 23.
Institute for Biological Interfaces III, Karlsruhe Institute of Technology, Herrmann-von-Helmholtz-Platz 1, D-76344, Eggenstein-Leopoldshafen, Germany.
Sulfur and its functional groups are major players in an area of exciting research taking place in modern polymer and materials science, both in academia and industry. In fact, manifold sulfur-based reactions that are both exceptionally versatile as well as tremendously useful have been implemented, and further utilized for the design and preparation of polymeric materials that lead to a plethora of applications ranging from medicine to optics and nanotechnology to separation science. Hence, within this review, an overview of strategies and developments used over the last 5 years to reinforce the importance of the sulfur functional group in modern polymer and materials science is presented. Read More
Front Neuroanat 2018 8;12:91. Epub 2018 Nov 8.
Center For Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, United States.
Our original review, "Heterogeneity and Diversity of Striatal GABAergic Interneurons," to which this is an invited update, was published in December, 2010 in Frontiers is Neuroanatomy. In that article, we reviewed several decades' worth of anatomical and electrophysiological data on striatal parvalbumin (PV)-, neuropeptide Y (NPY)- and calretinin(CR)-expressing GABAergic interneurons from many laboratories including our own. In addition, we reported on a recently discovered novel tyrosine hydroxylase (TH) expressing GABAergic interneuron class first revealed in transgenic TH EGFP reporter mouse line. Read More
Evol Appl 2018 Dec 28;11(10):1763-1778. Epub 2018 Jul 28.
School of Natural Sciences University of Tasmania Hobart Tasmania Australia.
Landscape genetics has provided many insights into how heterogeneous landscape features drive processes influencing spatial genetic variation in free-living organisms. This rapidly developing field has focused heavily on vertebrates, and expansion of this scope to the study of infectious diseases holds great potential for landscape geneticists and disease ecologists alike. The potential application of landscape genetics to infectious agents has garnered attention at formative stages in the development of landscape genetics, but systematic examination is lacking. Read More
J Cell Physiol 2018 Nov 19. Epub 2018 Nov 19.
Department of Cardiology, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.
Acute myocardial infarction (AMI), as a severe consequence of coronary atherosclerotic heart disease, always contributes to the loss of myocardial cells. Mounting evidence shows that annexin protects the myocardium from ischemic injury. In this study, we examine the inhibition of annexin A3 (ANXA3) on AMI through the phosphatidylinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Read More
Nat Commun 2018 11 19;9(1):4847. Epub 2018 Nov 19.
Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.
Synthetic biological circuits are designed to regulate gene expressions to control cell function. To date, these circuits often use DNA-delivery methods, which may lead to random genomic integration. To lower this risk, an all RNA system, in which the circuit and delivery method are constituted of RNA components, is preferred. Read More
Cell Stem Cell 2018 Dec 15;23(6):850-858.e4. Epub 2018 Nov 15.
Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan; Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Japan; Facility for iPS Cell Therapy, CiRA, Kyoto University, Kyoto, Japan. Electronic address:
Limited T cell availability and proliferative exhaustion present major barriers to successful T cell-based immunotherapies and may potentially be overcome through the use of "rejuvenated" induced pluripotent stem cells derived from antigen-specific T cells (T-iPSCs). However, strict antigen specificity is essential for safe and efficient T cell immunotherapy. Here, we report that CD8αβ T cells from human T-iPSCs lose their antigen specificity through additional rearrangement of the T cell receptor (TCR) α chain gene during the CD4/CD8 double positive stage of in vitro differentiation. Read More
J Comp Neurol 2018 Nov 17. Epub 2018 Nov 17.
Whitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida.
Ctenophores are descendants of one of the earliest branching metazoan lineage with enigmatic nervous systems. The lack of convenient neurogenic molecules and neurotransmitters suggests an extensive parallel evolution and independent origins of neurons and synapses. However, the field lags due to the lack of microanatomical data about the neuro-muscular systems in this group of animals. Read More
J Infect Dis 2018 Nov 15. Epub 2018 Nov 15.
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York.
Phys Rev Lett 2018 Nov;121(18):185701
ARC Centre of Excellence for Mathematical and Statistical Frontiers (ACEMS), School of Mathematical Sciences, Monash University, Clayton, Victoria 3800, Australia.
We address a long-standing debate regarding the finite-size scaling (FSS) of the Ising model in high dimensions, by introducing a random-length random walk model, which we then study rigorously. We prove that this model exhibits the same universal FSS behavior previously conjectured for the self-avoiding walk and Ising model on finite boxes in high-dimensional lattices. Our results show that the mean walk length of the random walk model controls the scaling behavior of the corresponding Green's function. Read More
Opt Lett 2018 Nov;43(22):5579-5582
A high repetition-rate, few-cycle light pulse is of great importance due to its potential for a variety of applications, including two-dimensional infrared spectroscopy and time-resolved imaging of molecular structures, which benefit from its ultrabroadband spectrum and ultrashort pulse duration. The generation of an ultrabroadband coherent spectrum is one of the frontiers of ultrafast optics, and accessing such few-cycle pulses is presently under active exploration. Here, we demonstrate a simple yet effective pulse synthesizer. Read More
Psychiatr Danub 2018 Nov;30(Suppl 7):511-514
Neamente Association, via San Pietro 27, - 80035 Nola (NA), Italy,
The reality of social networks in recent years has taken on new and enriching scenarios, to learn more about the problems and complex dynamics of life that surround the generations of preadolescents and adolescents. This work has matured over several years, interacting with schools in the Campania region (southern Italy), meeting and talking with teachers, parents and students, observing the reality that surrounds them. The territory of Naples and its province was the one in which the activity was mainly carried out. Read More
J Pharm Sci 2018 Nov 12. Epub 2018 Nov 12.
Merck & Co., Inc., West Point, Pennsylvania 19486.
Front Health Serv Manage 2018 ;35(2):1-2
Trudy Land, FACHE, is editor of Frontiers of Health Services Management.
Med Sci Sports Exerc 2018 Dec;50(12):2609-2610
Institute of Health and Biomedical Innovation and School of Exercise and Nutrition Sciences Queensland University of Technology Brisbane, Queensland, AUSTRALIA School of Mathematical Sciences and the Australian Research Council Centre of Excellence for Mathematical and Statistical Frontiers Queensland University of Technology Brisbane, Queensland, AUSTRALIA.
Int J Psychophysiol 2018 Nov 11;135:1-11. Epub 2018 Nov 11.
Graduate School of Information, Osaka University, Osaka, Japan.
The temporal pattern of spontaneous blinks changes greatly depending on an individual's internal cognitive state. For instance, when several individuals watch the same video, blinks can be synchronized at attentional breakpoints. The present study examined the degree of this blink synchronization, as reflecting an interest level, while viewing various video clips. Read More
Nanoscale 2018 Dec 14;10(45):21499-21508. Epub 2018 Nov 14.
Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education, School of Physical Science and Technology and Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou 730000, P. R. China.
Exchange-biased magnetic heterostructures have become one of the research frontiers due to their significance in enriching the fundamental knowledge in nanomagnetics and promising diverse applications in the information industry. However, the physical origin of their exchange bias effect is still controversial. A key reason for this is the lack of unequivocal observations of interface growth. Read More
Future Microbiol 2018 Nov 14. Epub 2018 Nov 14.
Merck & Co, Boston, MA 02115, USA.
The Editor of Future Microbiology speaks to Joan R Butterton, M.D., Associate Vice President and Section Head for Antibacterials and CMV for the Infectious Disease therapeutic area at Merck & Co. Read More
Front Microbiol 2018 30;9:2309. Epub 2018 Oct 30.
Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Departamento de Química and Centro de Biotecnología Daniel Alkalay Lowitt, Universidad Técnica Federico Santa María, Valparaíso, Chile.
Extremophiles are organisms capable of adjust, survive or thrive in hostile habitats that were previously thought to be adverse or lethal for life. Chile gathers a wide range of extreme environments: salars, geothermal springs, and geysers located at Altiplano and Atacama Desert, salars and cold mountains in Central Chile, and ice fields, cold lakes and fjords, and geothermal sites in Patagonia and Antarctica. The aims of this review are to describe extremophiles that inhabit main extreme biotopes in Chile, and their molecular and physiological capabilities that may be advantageous for bioremediation processes. Read More
Micromachines (Basel) 2018 Sep 6;9(9). Epub 2018 Sep 6.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Microscale neural technologies interface with the nervous system to record and stimulate brain tissue with high spatial and temporal resolution. These devices are being developed to understand the mechanisms that govern brain function, plasticity and cognitive learning, treat neurological diseases, or monitor and restore functions over the lifetime of the patient. Despite decades of use in basic research over days to months, and the growing prevalence of neuromodulation therapies, in many cases the lack of knowledge regarding the fundamental mechanisms driving activation has dramatically limited our ability to interpret data or fine-tune design parameters to improve long-term performance. Read More
Cyberpsychol Behav Soc Netw 2018 Nov 13. Epub 2018 Nov 13.
1 Clinical and Digital Health Sciences, College of Allied Health Sciences, Augusta University , Augusta, Georgia .
One of the most recent trends in technology field is the 360° technology. In order to investigate its potentiality for the evaluation of memory function, we compared participants' performance in two memory tasks between an encoding delivered through an immersive 360° environment and a non-immersive 360° one. Specifically, we investigated if the immersive 360° environment would facilitate memory encoding in comparison to the non-immersive 360° one. Read More
J Biomed Mater Res B Appl Biomater 2018 Nov 12. Epub 2018 Nov 12.
Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut.
Stem cell strategies and the use of electrical stimulation (ES) represent promising new frontiers for peripheral nerve regeneration. Composite matrices were fabricated by coating electrospun polycaprolactone/cellulose acetate micro-nanofibers with chitosan and ionically conductive (IC) polymers including, sulfonated polyaniline, and lignin sulfonate. These composite matrices were characterized for surface morphology, coating uniformity, ionic conductivity, and mechanical strength to explore as scaffold materials for nerve regeneration in conjunction with ES. Read More
Cell Tissue Res 2018 Nov 10. Epub 2018 Nov 10.
Department of Anatomy II, Jena University Hospital, Jena, Germany.