2,588 results match your criteria Frontiers in oncology[Journal]


MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.

Front Oncol 2019 29;9:29. Epub 2019 Jan 29.

Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.

Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Expression of a specific carbohydrate ligand for the immune-regulatory C-type lectin MGL was correlated to poor disease-specific survival and distant recurrences in squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC), the most common histological subtypes of cervical cancer. Read More

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http://dx.doi.org/10.3389/fonc.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361794PMC
January 2019

Long Non-coding RNA CDKN2B Antisense RNA 1 Gene Contributes to Paclitaxel Resistance in Endometrial Carcinoma.

Front Oncol 2019 29;9:27. Epub 2019 Jan 29.

School of Health Sciences, Macao Polytechnic Institute, Macau, China.

Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. In this study, we clarified the clinical significance of CDKN2B antisense RNA 1 (CDKN2B-AS) gene, and its effects on paclitaxel sensitivity in EC. Firstly, CDKN2B-AS gene was highly expressed in EC tissues and cell lines. Read More

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http://dx.doi.org/10.3389/fonc.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361746PMC
January 2019

EYA2 Correlates With Clinico-Pathological Features of Breast Cancer, Promotes Tumor Proliferation, and Predicts Poor Survival.

Front Oncol 2019 29;9:26. Epub 2019 Jan 29.

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Eyes absent homolog 2 (EYA2), a transcriptional activator, is pivotal for organ development, but aberrant regulation of EYA2 has been reported in multiple human tumors. However, the role of EYA2 in breast cancer is still lack of full understanding. To explore the biological significance of EYA2 in breast cancer, we conducted data analysis on public breast cancer datasets, and performed immunohistochemistry (IHC) analysis, colony-forming unit assays, EdU assay, western blotting, and immunofluorescence (IF). Read More

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http://dx.doi.org/10.3389/fonc.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361843PMC
January 2019

Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence.

Front Oncol 2019 30;9:22. Epub 2019 Jan 30.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Focal adhesion kinase (FAK) is a non-receptor kinase that facilitates tumor aggressiveness. The effects of FAK inhibition include arresting proliferation, limiting metastasis, and inhibiting angiogenesis. PF-573228 is an ATP-competitive inhibitor of FAK. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00022/
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http://dx.doi.org/10.3389/fonc.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363943PMC
January 2019
1 Read

BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Front Oncol 2019 29;9:16. Epub 2019 Jan 29.

Hematology and Transfusion Medicine Center, Instituto Nacional de Ciência e Tecnologia do Sangue, University of Campinas, Hemocentro-Unicamp, São Paulo, Brazil.

Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell-based disorders characterized by ineffective hematopoiesis, increased genomic instability and a tendency to progress toward acute myeloid leukemia (AML). MDS and AML cells present genetic and epigenetic abnormalities and, due to the heterogeneity of these molecular alterations, the current treatment options remain unsatisfactory. Hypomethylating agents (HMA), especially azacitidine, are the mainstay of treatment for high-risk MDS patients and HMA are used in treating elderly AML. Read More

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http://dx.doi.org/10.3389/fonc.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361844PMC
January 2019

21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery.

Front Oncol 2019 29;9. Epub 2019 Jan 29.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

To assess the role of the 21-gene recurrence score (RS) assay on decision-making of postoperative radiotherapy (RT) following breast-conserving surgery (BCS) in elderly women with early-stage breast cancer. The 21-gene RS for elderly (≥65 years) women with stage T1-2N0M0 estrogen receptor-positive breast cancer who underwent BCS from 2004 to 2015 was obtained from the Surveillance, Epidemiology, and End Results program. We estimated the association of 21-gene RS and adjuvant RT related to breast cancer-specific survival (BCSS) using propensity score matching (PSM). Read More

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http://dx.doi.org/10.3389/fonc.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361832PMC
January 2019

Celastrol Inhibits the Growth of Ovarian Cancer Cells and .

Front Oncol 2019 28;9. Epub 2019 Jan 28.

Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells and is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Read More

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http://dx.doi.org/10.3389/fonc.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360154PMC
January 2019
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Molecular, Biological and Structural Features of V CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells.

Front Oncol 2019 25;9:25. Epub 2019 Jan 25.

Department of Microbiology, Immunology and Parasitology, Experimental Oncology Unit, Federal University of São Paulo, São Paulo, Brazil.

Microtubules are important drug targets in tumor cells, owing to their role in supporting and determining the cell shape, organelle movement and cell division. The complementarity-determining regions (CDRs) of immunoglobulins have been reported to be a source of anti-tumor peptide sequences, independently of the original antibody specificity for a given antigen. We found that, the anti-Lewis B mAb light-chain CDR1 synthetic peptide Rb44, interacted with microtubules and induced depolymerization, with subsequent degradation of actin filaments, leading to depolarization of mitochondrial membrane-potential, increase of ROS, cell cycle arrest at G2/M, cleavage of caspase-9, caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2, altogether resulting in intrinsic apoptosis of melanoma cells. Read More

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http://dx.doi.org/10.3389/fonc.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355703PMC
January 2019

Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer.

Front Oncol 2019 25;9:21. Epub 2019 Jan 25.

Department of Anesthesiology, Dalian Medical University, Dalian, China.

A scorpion peptide reported to exhibit both analgesic and antitumor activity in animal models may present as an alternative therapeutic agent for breast cancer. We aimed to investigate the effect of antitumor-analgesic peptide (BmK AGAP) on breast cancer cell stemness and epithelial-mesenchymal transition (EMT). We treated MCF-7 and MDA-MB-231 cells with different concentrations of rBmK AGAP and observed that rBmK AGAP inhibited cancer cell stemness, epithelial-mesenchymal transition (EMT), migration, and invasion. Read More

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http://dx.doi.org/10.3389/fonc.2019.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355678PMC
January 2019
1 Read

Progression on Citrullination of Proteins in Gastrointestinal Cancers.

Front Oncol 2019 23;9:15. Epub 2019 Jan 23.

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory for Gastric Neoplasms, Shanghai, China.

The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis. The citrullination modification process is catalyzed by the peptidyl arginine deiminases (PADIs) family. Read More

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http://dx.doi.org/10.3389/fonc.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357933PMC
January 2019
1 Read

Merkel Cell Polyoma Viral Load and Intratumoral CD8+ Lymphocyte Infiltration Predict Overall Survival in Patients With Merkel Cell Carcinoma.

Front Oncol 2019 24;9:20. Epub 2019 Jan 24.

Department of Radiotherapy and Oncology, University of Frankfurt, Frankfurt, Germany.

Merkel cell carcinoma (MCC) is linked to the presence of clonally integrated Merkel cell polyomavirus (MCPyV) in up to 80% of the cases. The aim of the study was to determine the prognostic value of baseline MCPyV viral load and lymphocytic infiltration. MCPyV DNA prevalence, integration status and viral load were determined by specific quantitative real-time PCR in surgical specimens obtained from 49 patients with MCC treated with ( = 22, 45%) or without postoperative radiotherapy (RT). Read More

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http://dx.doi.org/10.3389/fonc.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354572PMC
January 2019

Corrigendum: CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria.

Front Oncol 2019 23;9:23. Epub 2019 Jan 23.

Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.

[This corrects the article DOI: 10.3389/fonc.2017. Read More

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http://dx.doi.org/10.3389/fonc.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352611PMC
January 2019

Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells.

Front Oncol 2019 23;9:13. Epub 2019 Jan 23.

Division of Head and Neck Oncologic and Microvascular Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, United States.

Epidermal growth factor receptor (EGFR) inhibitors have limited efficacy in head and neck squamous cell carcinoma (HNSCC) due to various resistance mechanisms, such as activation of the insulin-like growth factor-1 receptor (IGF1R), which initiates pro-survival signaling. Survivin, a member of the inhibitor of apoptosis proteins family, is expressed at relatively high levels in malignant tissues and plays a role in cell division. Expression of survivin in tumors has been shown to correlate with poor prognosis due to chemotherapy resistance and anti-apoptotic behavior. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00013/
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http://dx.doi.org/10.3389/fonc.2019.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351440PMC
January 2019
6 Reads

Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment.

Front Oncol 2019 23;9:10. Epub 2019 Jan 23.

Center for Theoretical Biological Physics, Rice University, Houston, TX, United States.

Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both cancer cells and different immune cells can display phenotypic plasticity in response to these communicating signals, thereby leading to complex spatiotemporal patterns that can impact therapeutic response. Here, we investigate the crosstalk between cancer cells and macrophages in a tumor microenvironment through (computational) co-culture models. Read More

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http://dx.doi.org/10.3389/fonc.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351454PMC
January 2019

Salt-Inducible Kinase 2: An Oncogenic Signal Transmitter and Potential Target for Cancer Therapy.

Front Oncol 2019 22;9:18. Epub 2019 Jan 22.

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Salt-inducible kinase (SIK), which belongs to the sucrose non-fermenting 1/AMP-activated protein kinase family, was first discovered in the adrenal cortex of a rat on a high-salt diet. As an isoform of the SIK family, SIK2 modulates various biological functions and acts as a signal transmitter in various pathways. Compared with that in adjacent normal tissues, the expression of SIK2 is significantly higher in multiple types of tumors, which indicates its pivotal effect in oncogenesis. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00018/
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http://dx.doi.org/10.3389/fonc.2019.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349817PMC
January 2019
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Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy.

Front Oncol 2019 22;9:17. Epub 2019 Jan 22.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Despite of remarkable progress made in the head and neck cancer (HNC) therapy, the survival rate of this metastatic disease remain low. Tailoring the appropriate therapy to patients is a major challenge and highlights the unmet need to have a good preclinical model that will predict clinical response. Hence, we developed an accurate and time efficient drug screening method of tumor analysis (TEVA) system, which can predict patient-specific drug responses. Read More

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http://dx.doi.org/10.3389/fonc.2019.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350270PMC
January 2019

The Expression Patterns of FAM83H and PANX2 Are Associated With Shorter Survival of Clear Cell Renal Cell Carcinoma Patients.

Front Oncol 2019 22;9:14. Epub 2019 Jan 22.

Department of Pathology, Chonbuk National University Medical School, Jeonju, South Korea.

FAM83H is primarily known for its role in amelogenesis; however, recent reports suggest FAM83H might be involved in tumorigenesis. Although the studies of FAM83H in kidney cancer are limited, a search of the public database shows a significant association between FAM83H and pannexin-2 (PANX2) in clear cell renal cell carcinomas (CCRCCs). Therefore, we evaluated the clinicopathological significance of the immunohistochemical expression of FAM83H and PANX2 in 199 CCRCC patients. Read More

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http://dx.doi.org/10.3389/fonc.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349742PMC
January 2019
2 Reads

Sources of Frustration Among Patients Diagnosed With Renal Cell Carcinoma.

Front Oncol 2019 22;9:11. Epub 2019 Jan 22.

Department of Urology, Ludwig-Maximilians University, Munich, Germany.

Despite numerous therapeutic advances in renal cell carcinoma (RCC), little is known about patients' perspectives on cancer care. An international survey was conducted to identify points of frustration associated with cancer care reported by patients with RCC. Data were obtained from an online survey, conducted from April 1 to June 15, 2017, through social media and patient networking platforms. Read More

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http://dx.doi.org/10.3389/fonc.2019.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349746PMC
January 2019
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Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Radiology, Michigan State University, East Lansing, MI, United States.

Ovarian cancer (OvCa) is the most lethal gynecologic malignancy, with two-thirds of patients having late-stage disease (II-IV) at diagnosis. Improved diagnosis and therapies are needed, yet preclinical animal models for ovarian cancer research have primarily been restricted to rodents, for data on which can fail to translate to the clinic. Thus, there is currently a need for a large animal OvCa model. Read More

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http://dx.doi.org/10.3389/fonc.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349777PMC
January 2019
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Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, United States.

Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. Read More

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http://dx.doi.org/10.3389/fonc.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350341PMC
January 2019
1 Read

Dosimetric Performance and Planning/Delivery Efficiency of a Dual-Layer Stacked and Staggered MLC on Treating Multiple Small Targets: A Planning Study Based on Single-Isocenter Multi-Target Stereotactic Radiosurgery (SRS) to Brain Metastases.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States.

To evaluate the dosimetric performance and planning/delivery efficiency of a dual-layer MLC system for treating multiple brain metastases with a single isocenter. 10 patients each with 6-10 targets with volumes from 0.11 to 8. Read More

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http://dx.doi.org/10.3389/fonc.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349708PMC
January 2019

A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study).

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by cisplatin and radiotherapy is controversial because of toxicity concerns. The aim of this phase II study was to assess the feasibility of docetaxel, cisplatin, and cetuximab (TPEx) followed by cetuximab and concurrent radiotherapy for LA SCCHN. Read More

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http://dx.doi.org/10.3389/fonc.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349830PMC
January 2019
1 Read

Association Between Physical Activity and Lower Risk of Lung Cancer: A Meta-Analysis of Cohort Studies.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.

Epidemiological evidences regarding the association between physical activity and the risk of lung cancer are still controversial. We aimed to investigate the relationship between physical activity and risk of lung cancer in men and women, as well as other high-risk populations such as cigarette smokers. We conducted a meta-analysis of cohort studies to evaluate the association between physical activity and risk of lung cancer. Read More

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http://dx.doi.org/10.3389/fonc.2019.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349707PMC
January 2019
1 Read

Pericardial Effusion With Tamponade in Lung Cancer Patients During Treatment With Nivolumab: A Report of Two Cases.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Nivolumab is an immune checkpoint inhibitor (ICI) that has shown efficacy for treating non-small cell lung cancer and has become a standard therapy for previously treated non-small cell lung cancer. Moreover, immune-related adverse events of ICI therapy are well-known. Malignant pericardial effusions occasionally arise in patients with lung cancer. Read More

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http://dx.doi.org/10.3389/fonc.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349695PMC
January 2019

Health Behaviors and Lifestyle Interventions in African American Breast Cancer Survivors: A Review.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Department of Community Medicine and Population Health, The University of Alabama, Tuscaloosa, AL, United States.

African American breast cancer survivors have a higher incidence of estrogen receptor negative and basal-like (e.g., triple negative) tumors, placing them at greater risk for poorer survival when compared to women of other racial and ethnic groups. Read More

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http://dx.doi.org/10.3389/fonc.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349825PMC
January 2019

CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma.

Front Oncol 2018 22;8:682. Epub 2019 Jan 22.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

The chemokine ligands and their receptors play critical roles in cancer progression and patients outcomes. We found that CXCL13 was significantly upregulated in ccRCC tissues compared with normal tissues in both The Cancer Genome Atlas (TCGA) cohort and a validated cohort of 90 pairs ccRCC tissues. Statistical analysis showed that high CXCL13 expression related to advanced disease stage and poor prognosis in ccRCC. Read More

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http://dx.doi.org/10.3389/fonc.2018.00682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349755PMC
January 2019
1 Read

Inequality in the Survival of Patients With Head and Neck Cancer in Scotland.

Front Oncol 2018 22;8:673. Epub 2019 Jan 22.

University of Glasgow Dental School, University of Glasgow, Glasgow, United Kingdom.

Socioeconomic inequalities impact on the survival of head and neck cancer (HNC) patients, but there is limited understanding of the explanations of the inequality, particularly in long-term survival. Patients were recruited from the Scottish Audit of Head and Neck Cancer between 1999 and 2001 and were linked to mortality data as at 30th September 2013. Socioeconomic status was determined using the area-based Carstairs 2001 index. Read More

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http://dx.doi.org/10.3389/fonc.2018.00673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349751PMC
January 2019

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity.

Front Oncol 2018 22;8:670. Epub 2019 Jan 22.

Departments of Radiation Oncology, Mayo Clinic, Rochester, MN, United States.

Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM cells to chemo-radiation is expected to extend survival of patients with GBM by enhancing treatment efficacy. Read More

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http://dx.doi.org/10.3389/fonc.2018.00670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349736PMC
January 2019
2 Reads

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma.

Front Oncol 2019 21;9:19. Epub 2019 Jan 21.

Immunicum AB, Stockholm, Sweden.

Several lines of evidence support immunotherapy in hepatocellular carcinoma (HCC). We have shown that intratumoral injections of the immune primer ilixadencel (pro-inflammatory allogeneic dendritic cells) are safe in renal-cell carcinoma. Here, we assessed ilixadencel as a single agent and combined with sorafenib in advanced HCC. Read More

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http://dx.doi.org/10.3389/fonc.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348253PMC
January 2019
1 Read

Gene Expression and Methylation Analysis in Melanomas and Melanocytes From the Same Patient: Loss of NPM2 Expression Is a Potential Immunohistochemical Marker for Melanoma.

Front Oncol 2018 21;8:675. Epub 2019 Jan 21.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan.

DNA methylation is considered the primary epigenetic mechanism underlying the development of malignant melanoma. Since DNA methylation can be influenced by environmental factors, it is preferable to compare cancer and normal cells from the same patient. In order to compare the methylation status in melanoma tissues and melanocytes from the same individuals, we employed a novel epidermal sheet cultivation technique to isolate normal melanocytes from unaffected sites of melanoma patients. Read More

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http://dx.doi.org/10.3389/fonc.2018.00675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348333PMC
January 2019

Identification of Serum MicroRNAs as Novel Biomarkers in Esophageal Squamous Cell Carcinoma Using Feature Selection Algorithms.

Front Oncol 2018 21;8:674. Epub 2019 Jan 21.

Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.

Circulating microRNAs (miRNAs) are promising molecular biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC). We investigated the serum miRNA expression profiles from microarray-based technologies and evaluated the diagnostic value of serum miRNAs as potential biomarkers for ESCC by using feature selection algorithms. Serum miRNA expression profiles were obtained from 52 ESCC patients and 52 age- and sex-matched controls via performing a high-throughput microarray assay. Read More

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http://dx.doi.org/10.3389/fonc.2018.00674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348251PMC
January 2019

Optimal Extent of Transhiatal Gastrectomy and Lymphadenectomy for the Stomach-Predominant Adenocarcinoma of Esophagogastric Junction: Retrospective Single-Institution Study in China.

Front Oncol 2018 21;8:639. Epub 2019 Jan 21.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

The optimal extent of gastrectomy and lymphadenectomy for esophagogastric junction (EGJ) cancer is controversial. Our study aimed to compare the long-term survival of transhiatal proximal gastrectomy with extended periproximal lymphadenectomy (THPG with EPL) and transhiatal total gastrectomy with complete perigastric lymphadenectomy (THTG with CPL) for patients with the stomach-predominant EGJ cancer. Between January 2004, and August 2015, 306 patients with Siewert II tumors were divided into the THTG group ( = 148) and the THPG group ( = 158). Read More

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http://dx.doi.org/10.3389/fonc.2018.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348947PMC
January 2019

Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol.

Front Oncol 2018 18;8:643. Epub 2019 Jan 18.

Department of Pathology, Santa Casa de São Paulo, São Paulo, Brazil.

We describe two patients with a confirmed diagnosis of high-grade gliomas (grades III/IV), both presenting with O6-methylguanine-DNA methyltransferase (MGMT) methylated and isocitrate dehydrogenase (IDH-1) mutated who, after subtotal resection, were submitted to chemoradiation and followed by PCV, a multiple drug regimen (procarbazine, lomustine, and vincristine) associated with cannabidiol (CBD). Both patients presented with satisfactory clinical and imaging responses at periodic evaluations. Immediately after chemoradiation therapy, one of the patients presented with an exacerbated and precocious pseudoprogression (PSD) assessed by magnetic resonance imaging (MRI), which was resolved in a short period. Read More

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http://dx.doi.org/10.3389/fonc.2018.00643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345719PMC
January 2019

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.

Front Oncol 2018 17;8:681. Epub 2019 Jan 17.

School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Human castration-resistant prostate cancer (CRPC) is a significant target of clinical research. The use of DNA-damaging agents has a long history in cancer chemotherapy but is limited by their toxicities. The combination with a safer drug can be a strategy in reducing dosage and toxicity while increasing anticancer activity in CRPC treatment. Read More

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http://dx.doi.org/10.3389/fonc.2018.00681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344441PMC
January 2019
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Clinical Utilization Pattern of Liquid Biopsies (LB) to Detect Actionable Driver Mutations, Guide Treatment Decisions and Monitor Disease Burden During Treatment of 33 Metastatic Colorectal Cancer (mCRC) Patients (pts) at a Fox Chase Cancer Center GI Oncology Subspecialty Clinic.

Front Oncol 2018 17;8:652. Epub 2019 Jan 17.

Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, United States.

Liquid biopsy (LB) captures dynamic genomic alterations (alts) across metastatic colorectal cancer (mCRC) therapy and may complement tissue biopsy (TB). We sought to describe the utility of LB and better understand mCRC biology during therapy. Thirty-three patients (pts) with mCRC underwent LB. Read More

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http://dx.doi.org/10.3389/fonc.2018.00652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344461PMC
January 2019
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Elevated Neutrophil to Lymphocyte Ratio Predicts Poor Prognosis in Non-muscle Invasive Bladder Cancer Patients: Initial Intravesical Bacillus Calmette-Guerin Treatment After Transurethral Resection of Bladder Tumor Setting.

Front Oncol 2018 17;8:642. Epub 2019 Jan 17.

Department of Urology, Seoul National University Hospital, Seoul, South Korea.

The objective of this study was to investigate pretreatment systemic inflammatory response (SIR) markers in patients who underwent initial intravesical treatment for high-risk non-muscle invasive bladder cancer (NMIBC). A total of 385 patients who underwent initial intravesical Bacillus Calmette-Guerin treatment after transurethral resection of bladder tumor (TURB) were included. We analyzed the relationship between oncological outcomes and ratios of SIR markers, including neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), and platelet-to-lymphocyte ratio (PLR). Read More

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http://dx.doi.org/10.3389/fonc.2018.00642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344445PMC
January 2019

Exploring the Potential Utility of Pet Dogs With Cancer for Studying Radiation-Induced Immunogenic Cell Death Strategies.

Front Oncol 2018 15;8:680. Epub 2019 Jan 15.

Comparative Oncology Research Laboratory, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign Urbana, IL, United States.

Radiotherapy serves as a foundational pillar for the therapeutic management of diverse solid tumors through the generation of lethal DNA damage and induction of cell death. While the direct cytotoxic effects of radiation therapy remain a cornerstone for cancer management, in the era of immunooncology there is renewed and focused interest in exploiting the indirect bystander activities of radiation, termed abscopal effects. In radioimmunobiologic terms, abscopal effects describe the radiotherapy-induced regression of cancerous lesions distant from the primary site of radiation delivery and rely upon the induction of immunogenic cell death and consequent systemic anticancer immune activation. Read More

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http://dx.doi.org/10.3389/fonc.2018.00680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340932PMC
January 2019

Combination of Oncolytic Measles Virus Armed With BNiP3, a Pro-apoptotic Gene and Paclitaxel Induces Breast Cancer Cell Death.

Front Oncol 2018 15;8:676. Epub 2019 Jan 15.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

Breast cancer is one of the major causes of cancer related mortality in women worldwide. Limitations of conventional anti-cancer therapies such as severe systemic side effects, narrow therapeutic index, non-specificity, and non-availability of drugs for all types of cancers has resulted in the development of various novel and targeted approaches. The use of viruses as oncolytic agents has gained momentum for the development of an efficient therapeutic platform. Read More

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http://dx.doi.org/10.3389/fonc.2018.00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340943PMC
January 2019

Comparison of Different Lymph Node Staging Systems in Patients With Resectable Colorectal Cancer.

Front Oncol 2018 15;8:671. Epub 2019 Jan 15.

Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Currently, the United States Joint Commission on Cancer (AJCC) N staging, lymph node positive rate (LNR), and log odds of positive lymph nodes (LODDS) are the main lymph node (LN) staging systems. However, the type of LN staging system that is more accurate in terms of prognostic performance remains controversial. We compared the prognostic accuracy of the three staging systems in patients with CRC and determine the best choice for clinical applications. Read More

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http://dx.doi.org/10.3389/fonc.2018.00671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340930PMC
January 2019

Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response.

Front Oncol 2018 15;8:669. Epub 2019 Jan 15.

Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States.

Measurable residual disease (MRD) testing after initial chemotherapy treatment can predict relapse and survival in acute myeloid leukemia (AML). However, it has not been established if repeat molecular or genetic testing during chemotherapy can offer information regarding the chemotherapy sensitivity of the leukemic clone. Blood from 45 adult AML patients at day 1 and 4 of induction ( = 35) or salvage ( = 10) cytotoxic chemotherapy was collected for both quantitative real-time PCR (qPCR) assessment () and next generation sequencing (>500 × depth) of 49 gene regions recurrently mutated in MDS/AML. Read More

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http://dx.doi.org/10.3389/fonc.2018.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341003PMC
January 2019

The Role of COL5A2 in Patients With Muscle-Invasive Bladder Cancer: A Bioinformatics Analysis of Public Datasets Involving 787 Subjects and 29 Cell Lines.

Front Oncol 2018 15;8:659. Epub 2019 Jan 15.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Bladder cancer (BC) is one of the most common malignancies. Two previous studies identified collagen type V alpha 2 (COL5A2) as a potential biomarker in BC, both are simple reanalysis of a single transcriptomic dataset without subgroup analysis for muscle-invasive BC (MIBC). We focused in MIBC patients and explored the role of COL5A2 from an integration perspective, using refined methodology covering individual participant data meta-analysis and bioinformatics analysis. Read More

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http://dx.doi.org/10.3389/fonc.2018.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340941PMC
January 2019
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Aspirin Inhibits Natural Killer/T-Cell Lymphoma by Modulation of VEGF Expression and Mitochondrial Function.

Front Oncol 2018 14;8:679. Epub 2019 Jan 14.

Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, China.

Extranodal nasal-type natural killer/T-cell lymphoma (NKTCL) is an Epstein-Barr virus (EBV)-associated lymphoma with a strong tendency relapse or be refractory in response to chemotherapy. Development of a new strategy for NKTCL treatment is still quite necessary. In this study, we found that aspirin treatment suppresses VEGF expression in NKTCL SNK-6 cells. Read More

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http://dx.doi.org/10.3389/fonc.2018.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339948PMC
January 2019

Is Proton Therapy a "Pro" for Breast Cancer? A Comparison of Proton vs. Non-proton Radiotherapy Using the National Cancer Database.

Front Oncol 2018 14;8:678. Epub 2019 Jan 14.

Department of Therapeutic Radiology, Smilow Cancer Center, Yale University School of Medicine, New Haven, CT, United States.

Limited data exists demonstrating the clinical benefit of proton radiotherapy (PRT) in breast cancer. Using the National Cancer Database, we evaluated predictors associated with PRT use for patients with breast cancer. An exploratory analysis also investigates the impact of PRT on overall survival (OS). Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00678/
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http://dx.doi.org/10.3389/fonc.2018.00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339938PMC
January 2019
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Modeling Gene-Environment Interaction for the Risk of Non-hodgkin Lymphoma.

Front Oncol 2018 14;8:657. Epub 2019 Jan 14.

Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

Non-hodgkin lymphoma (NHL) is one of the most common and deadly cancers. There is limited analysis of gene-environment interactions for the risk of NHL. This study intends to explore the interactions between genetic variants and environmental factors, and how they contribute to NHL risk. Read More

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http://dx.doi.org/10.3389/fonc.2018.00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340069PMC
January 2019

Patterns of Tumor Progression Predict Small and Tissue-Specific Tumor-Originating Niches.

Front Oncol 2018 10;8:668. Epub 2019 Jan 10.

Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

The development of cancer is a multistep process in which cells increase in malignancy through progressive alterations. Such altered cells compete with wild-type cells and have to establish within a tissue in order to induce tumor formation. The range of this competition and the tumor-originating cell type which acquires the first alteration is unknown for most human tissues, mainly because the involved processes are hardly observable, aggravating an understanding of early tumor development. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00668/
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http://dx.doi.org/10.3389/fonc.2018.00668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335293PMC
January 2019
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Strategies of the War on Cancer: To Kill or to Neutralize?

Front Oncol 2018 10;8:667. Epub 2019 Jan 10.

Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Moscow, Russia.

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http://dx.doi.org/10.3389/fonc.2018.00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335948PMC
January 2019

Deregulation and Targeting of TP53 Pathway in Multiple Myeloma.

Front Oncol 2018 9;8:665. Epub 2019 Jan 9.

IRCL, INSERM UMR-S1172, University of Lille, Lille, France.

Multiple Myeloma (MM) is an incurable disease characterized by a clonal evolution across the course of the diseases and multiple lines of treatment. Among genomic drivers of the disease, alterations of the tumor suppressor are associated with poor outcomes. In physiological situation, once activated by oncogenic stress or DNA damage, p53 induces either cell-cycle arrest or apoptosis depending on the cellular context. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00665/
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http://dx.doi.org/10.3389/fonc.2018.00665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333636PMC
January 2019
11 Reads

Inequality in the Incidence of Cervical Cancer: Costa Rica 1980-2010.

Front Oncol 2018 10;8:664. Epub 2019 Jan 10.

Health Surveillance Department, Ministry of Health Costa Rica, San José, Costa Rica.

Cervical cancer is the third most incident and the fourth most lethal cancer among Costa Rican women. The purpose of this study was to quantify incidence inequality along three decades and to explore its determinants. This is a population-based study. Read More

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http://dx.doi.org/10.3389/fonc.2018.00664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335361PMC
January 2019

A Care Process Model to Deliver Lu-Dotatate Peptide Receptor Radionuclide Therapy for Patients With Neuroendocrine Tumors.

Front Oncol 2018 9;8:663. Epub 2019 Jan 9.

Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Jacksonville, FL, United States.

To develop a care process model for the delivery of peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-Dotatate for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A multidisciplinary, structured PRRT process model was established. Over the last 9 months, meetings were held bi-weekly to discuss the logistics of clinical trials. Read More

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http://dx.doi.org/10.3389/fonc.2018.00663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333662PMC
January 2019

PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression.

Front Oncol 2018 9;8:661. Epub 2019 Jan 9.

Division of Hepatology, Diabetology and Endocrinology, Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan.

While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined the cell cycle regulators whose activation is affected by PDCD4 knockdown to investigate the contribution of PDCD4 to cell cycle regulation in three types of hepatoma cells: HepG2, Huh7 (mutant p53 and p16-deficient), and Hep3B (p53- and Rb-deficient). PDCD4 knockdown suppressed cell growth in all three cell lines by inhibiting Rb phosphorylation via down-regulating the expression of Rb itself and CDKs, which phosphorylate Rb, and up-regulating the expression of the CDK inhibitor p21 through a p53-independent pathway. Read More

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http://dx.doi.org/10.3389/fonc.2018.00661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334536PMC
January 2019