4,864 results match your criteria Frontal Lobe Syndromes


Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis.

Behav Neurol 2019 13;2019:9518309. Epub 2019 Mar 13.

Sunnybrook Research Institute, Hurvitz Brain Sciences Program, Toronto, Canada.

The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades. Read More

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http://dx.doi.org/10.1155/2019/9518309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436339PMC

Emotional asymmetries in refractory medial temporal and frontal lobe epilepsy: Their impact on predicting lateralization and localization of seizures.

Epilepsy Behav 2019 Apr 10;94:269-276. Epub 2019 Apr 10.

Department of Neurosurgery, Epilepsy Surgery Unit, School of Medicine, Evangelismos Hospital, University of Athens, Greece.

Background: Emotional disturbances have been reported in patients with epilepsy. Although conflicting results emanate from relevant studies, depressive symptoms are seen more often in temporal lobe epilepsy (TLE) whereas, hypomanic/manic symptoms usually accompany frontal lobe epilepsy (FLE); the above psychiatric symptoms are especially seen in refractory epilepsy. However, neocortical TLE and medial TLE are considered as distinct epileptic syndromes, and there is limited literature on comparison of affective traits in medial TLE (MTLE) and FLE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.008DOI Listing

Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease.

Neuroimage Clin 2019 Apr 3;23:101811. Epub 2019 Apr 3.

Department of Bio-convergence Engineering, Korea University, Seoul, Republic of Korea; School of Biomedical Engineering, Korea University, Seoul, Republic of Korea. Electronic address:

Background: In a clinical setting, an individual subject classification model rather than a group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns of atrophy among three FTD clinical syndromes including behavioral variant FTD (bvFTD), non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA) give rise to the need for classification models at the individual level. In this study, we aimed to classify each individual subject into one of the diagnostic categories in a hierarchical manner by employing a machine learning-based classification method. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458431PMC
April 2019
2 Reads

Autopsied case with MERRF/MELAS overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus.

Neuropathology 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

We present an autopsied case with A8344G-mutated myoclonus epilepsy with ragged red fibers (MERRF)/mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus. A 16-year-old Japanese woman suddenly experienced repetitive consciousness disturbances with increased serum lactate and creatine kinase levels. Magnetic resonance imaging showed abnormal intensity of bilateral precentral gyrus. Read More

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http://dx.doi.org/10.1111/neup.12551DOI Listing
April 2019
1 Read

The role of the IPL in person identification.

Neuropsychologia 2019 Apr 2;129:164-170. Epub 2019 Apr 2.

Centre for Cognitive Neuroscience, Department of Psychology, University of Salzburg, 5020, Salzburg, Austria.

We investigate the brain activations when identifying a newly encountered individual as being the same as a person previously perceived, a fundamental but seldom acknowledged process. In an identity condition, two faces had to be identified as the same person in contrast to a control condition, in which two faces had to be recognised as belonging to similar looking twins. Our results demonstrate an increase of neural activation in frontal as well as in parietal areas including the left inferior parietal lobe and the precuneus during identification. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.03.019DOI Listing

Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome.

Neurobiol Aging 2019 Mar 11;78:186-194. Epub 2019 Mar 11.

Obsessive-Compulsive Spectrum Disorders Program, PROTOC, Department and Institute of Psychiatry, University of São Paulo School of Medicine, FMUSP, São Paulo, Brazil.

There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (≥30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apathy) by an informant using the Frontal Systems Behavior Scale. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.028DOI Listing
March 2019
4 Reads

Gender and Hemispheric Asymmetries in Acquired Sociopathy.

Front Psychol 2019 19;10:346. Epub 2019 Mar 19.

Shirley Ryan AbilityLab, Department of Physical Medicine, Rehabilitation, and Psychology, Neurology, Cognitive Neurology and Alzheimer's Center, Feinberg School of Medicine, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL, United States.

The emergence of enduring antisocial personality changes in previously normal individuals, or "acquired sociopathy," has consistently been reported in patients with bilateral injuries of the ventromedial prefrontal cortex. Over the past three decades, cases of acquired sociopathy with (a) bilateral or (b) unilateral sparing of the ventromedial prefrontal cortex have been reported. These cases indicate that at least in a few individuals (a') neural structures beyond the ventromedial prefrontal cortex are also critical for normal social behavior, and (b') the neural underpinnings of social cognition may be lateralized to one cerebral hemisphere. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433972PMC
March 2019
1 Read

Alzheimer's Disease Including Focal Presentations.

Semin Neurol 2019 Apr 29;39(2):213-226. Epub 2019 Mar 29.

Department of Neurology, Institute of Memory and Alzheimer's Disease, Assistance Publique - Hopitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Read More

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http://dx.doi.org/10.1055/s-0039-1681041DOI Listing
April 2019
2 Reads

Serum insulin-like growth factor-1 levels in neurodegenerative diseases.

Acta Neurol Scand 2019 Mar 23. Epub 2019 Mar 23.

Department of Neurology, Dokkyo Medical University, Mibu, Japan.

Background: We investigated serum insulin-like growth factor (IGF)-1 levels in patients with neurodegenerative diseases and correlated these levels with clinical parameters.

Methods: One hundred and fifty-six patients with neurodegenerative diseases were included in this study, and serum IGF-1 levels were determined.

Results: Serum IGF-1 levels (mean ± standard error) were not significantly different among the patients with different neurodegenerative diseases: Parkinson's disease (PD; n = 73), 112. Read More

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http://dx.doi.org/10.1111/ane.13091DOI Listing
March 2019
1 Read

Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder.

Front Psychiatry 2019 19;10:52. Epub 2019 Feb 19.

Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.

Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389674PMC
February 2019
1 Read

Temporal glioblastoma presenting as catatonia.

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

Academic Center for ECT and Neuromodulation (AcCENT), Universitair Psychiatrisch Centrum KU Leuven, Kortenberg, Belgium.

The objective of this article is to describe the possible association of catatonia and temporal brain lesions. This is a case presentation of a 57-year-old man presenting with depression, with catatonia secondary to a temporal glioblastoma. He was referred to hospital because for a sudden deterioration in depressed state. Read More

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http://dx.doi.org/10.1136/bcr-2017-224017DOI Listing

Change of Cerebral Blood Flow After a Successful Pharmacological Treatment of Phantom Bite Syndrome: A Case Report.

Clin Neuropharmacol 2019 Mar/Apr;42(2):49-51

Department of Psychosomatic Dentistry and.

Background: "Phantom bite syndrome," a persistent complaint of an uncomfortable bite sensation with no obvious occlusal abnormal finding, recently was suggested to be related with central nervous system dysfunction. Here, we report a case of phantom bite syndrome in which the occlusal discomfort was improved with mirtazapine and aripiprazole combination parallel with regional cerebral blood flow change.

Case Report: A 60-year-old-female patient came to our clinic with the chief complaint of a "loosely bite" after dental treatment and various uncomfortable sensations of body sites. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426344PMC
February 2019
1 Read

Role of Frontal Functions in Executing Routine Sequential Tasks.

Front Psychol 2019 6;10:169. Epub 2019 Feb 6.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.

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http://dx.doi.org/10.3389/fpsyg.2019.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372513PMC
February 2019

DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb;21(1):42-47

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019
1 Read

Recovery time from supplementary motor area syndrome: relationship to postoperative day 7 paralysis and damage of the cingulum.

J Neurosurg 2019 Feb 8:1-10. Epub 2019 Feb 8.

2Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; and.

OBJECTIVESupplementary motor area (SMA) syndrome is defined as temporary paralysis after the resection of brain tumor localized in the SMA. Although in most cases paralysis induced by SMA resection resolves within a short period, the time until complete recovery varies and has not been precisely analyzed to date. In this study, the authors investigated factors for predicting the time required for recovery from paralysis after SMA resection. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182391DOI Listing
February 2019
2 Reads

Atypical posterior reversible encephalopathy syndrome in a noncompliant hemodialysis patient: Case report and literature review.

Hemodial Int 2019 Feb 8. Epub 2019 Feb 8.

Division of Neurology, Department of Medicine, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan.

Posterior reversible encephalopathy syndrome (PRES) is a reversible vasogenic brain edema in patients who present with seizure, headache, visual disturbance, and altered mental status, and a characteristic neuroimaging profile. Although PRES predominantly affects the bilateral parieto-occipital areas, involvement of the frontal and temporal lobes, basal ganglia, brainstem, and cerebellum is not uncommon. Isolated involvement of the brainstem and cerebellum sparing the parieto-occipital lobe is rarely reported. Read More

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http://doi.wiley.com/10.1111/hdi.12735
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http://dx.doi.org/10.1111/hdi.12735DOI Listing
February 2019
9 Reads

Behavioural changes as the first manifestation of a silent frontal lobe stroke.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Intensive Care Medicine, Hospital Universitario de Mostoles, Mostoles, Spain.

A 67-year-old man was admitted to our hospital after his relatives found him to have severe personality and behavioural changes. His behaviour was inappropriate and uninhibited. The patient reported no symptoms and he showed poor insight into his own behaviour. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22761
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http://dx.doi.org/10.1136/bcr-2018-227617DOI Listing
January 2019
13 Reads

Posterior Reversible Encephalopathy Syndrome with Stroke in Puerperal Woman with High Titer of Anti-Phospholipid IgM Antibody.

Case Rep Obstet Gynecol 2018 3;2018:7438676. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.

Posterior reversible encephalopathy syndrome with stroke is very rare in puerperal women. A 36-year-old nulliparous woman with both rheumatoid arthritis and recurrent pregnancy loss, probably due to a high titer of anti-phospholipid IgM antibody, was referred at 10 weeks of gestation. Low-dose aspirin at 100 mg/day and heparin calcium subcutaneous injection at 10,000 units/day were started before pregnancy and stopped at 35 and 40 weeks, respectively. Read More

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https://www.hindawi.com/journals/criog/2018/7438676/
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http://dx.doi.org/10.1155/2018/7438676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304583PMC
December 2018
13 Reads

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods.

Epilepsy Behav Case Rep 2019 1;11:39-42. Epub 2018 Nov 1.

Brno Epilepsy Centre, Department of Paediatric Neurology, University Hospital, Masaryk University, Brno, Czech Republic.

Purpose: Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313257PMC
November 2018
17 Reads

Alterations of Graphic Properties and Related Cognitive Functioning Changes in Mild Alzheimer's Disease Revealed by Individual Morphological Brain Network.

Front Neurosci 2018 10;12:927. Epub 2018 Dec 10.

Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Alzheimer's disease (AD) is one of the most common forms of dementia that has slowly negative impacts on memory and cognition. With the assistance of multimodal brain networks and graph-based analysis approaches, AD-related network disruptions support the hypothesis that AD can be identified as a dysconnectivity syndrome. However, as the recent emerging of individual-based morphological network research of AD, the utilization of multiple morphometric features may provide a broader horizon for locating the lesions. Read More

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http://dx.doi.org/10.3389/fnins.2018.00927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295573PMC
December 2018
3 Reads

Neuro-Behçet's disease presenting as an isolated progressive cognitive and behavioral syndrome.

Neurocase 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Second Division of Neurology , Center for Rare Neurological and Neuromuscular Diseases & Inter University Center for Research in Neurosciences, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli , Naples , Italy.

Behçet's disease is a chronic inflammatory disorder manifesting as a vasculitis that affects arteries and veins of any size. Up to 44% of cases may also present with neurological symptoms, thus defining Neuro-Behçet's disease. We describe a case of Neuro-Behçet's disease characterized by progressive behavioral and cognitive deterioration prevailing over other neurological symptoms, without evident systemic involvement. Read More

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http://dx.doi.org/10.1080/13554794.2018.1561898DOI Listing
December 2018

Common findings on head computed tomography in neonates with confirmed congenital Zika syndrome.

Radiol Bras 2018 Nov-Dec;51(6):366-371

Hospital Barão de Lucena (HBL), Recife, PE, Brazil.

Objective: To describe head computed tomography (CT) findings in neonates with congenital Zika virus infection confirmed in cerebrospinal fluid.

Materials And Methods: This was a study of 16 newborn infants who exhibited abnormal head CT findings during an outbreak of Zika virus infection. Those infants had the following features: brain imaging suggestive of congenital infection; brain calcifications and negative results on tests for other main infectious causes of primary microcephaly, namely toxoplasmosis, cytomegalovirus, rubella, and HIV; positivity for Zika virus on IgM antibody capture enzyme-linked immunosorbent assay in cerebrospinal fluid. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2017.0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290748PMC
December 2018
12 Reads

Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging.

Radiol Case Rep 2019 Mar 5;14(3):309-314. Epub 2018 Dec 5.

Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 80131 Naples, Italy.

X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease affecting the nervous system and the adrenal glands. It is caused by a mutation of the gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues. X-ALD is notable for its high phenotypical variability, that includes isolated adrenocortical insufficiency, slowly progressive myelopathy with paraparesis, ataxia, and peripheral neuropathy to severe childhood cerebral forms. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282458PMC
March 2019
2 Reads

Posterior reversible encephalopathy syndrome.

Curr Opin Neurol 2019 Feb;32(1):25-35

Center for Stroke Research Berlin (CSB).

Purpose Of Review: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by acute cerebral endotheliopathy with consecutive disruption of the blood-brain barrier and vasogenic edema. Since its first description in 1996, PRES is increasingly recognized. However, many aspects of this syndrome with its wide spectrum of clinical and radiological features are still incompletely understood. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000640DOI Listing
February 2019
3 Reads

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec;20(6):490-501

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1014DOI Listing
December 2018
2 Reads

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec;20(6):457-467

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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http://dx.doi.org/10.1684/epd.2018.1009DOI Listing
December 2018
8 Reads

Carotid Artery Stenting for Symptomatic Internal Carotid Artery Stenosis Associated with Moyamoya Disease.

World Neurosurg 2019 Mar 5;123:76-80. Epub 2018 Dec 5.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Surgical intervention in a case of internal carotid artery stenosis with moyamoya vessels has not been well described. We present a case with detailed description of the surgical procedure and perioperative management.

Case Description: A 58-year-old man with symptomatic internal carotid artery stenosis had concurrent moyamoya vessels intracranially. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.204DOI Listing
March 2019
3 Reads

Paraneoplastic syndrome or metastatic sinonasal neuroendocrine carcinoma? Clinical conundrum.

Ear Nose Throat J 2018 Oct-Nov;97(10-11):E15-E18

Department of Neurosurgery, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.

We report a case of a middle-aged woman with a diffuse, nonenhancing, progressively atrophic T2-hyperintense lesion involving the left frontotemporal lobes and insula found to be synchronous high-grade sinonasal neuroendocrine carcinoma (SNEC) after initial endonasal resection. In 2014, a 47-year old woman underwent resection of a left-sided high-grade ethmoidal neuroendocrine carcinoma after presentation with weight gain and increased levels of serum and urine cortisol. Concurrent with the initial presentation, she was noted to have a nonenhancing, hyperintense signal change on T2-weighted images on the left frontotemporal lobes and insula thought to be paraneoplastic. Read More

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March 2019
19 Reads
0.881 Impact Factor

Periventricular nodular heterotopia in 22q11.2 deletion and frontal lobe migration.

Ann Clin Transl Neurol 2018 Nov 23;5(11):1314-1322. Epub 2018 Sep 23.

Division of Neurology Department of Medicine Krembil Neuroscience Centre Toronto Western Hospital University of Toronto Toronto Ontario Canada.

Objective: We aimed to delineate the distribution of periventricular nodular heterotopia (PNH) in patients with 22q11.2 microdeletion syndrome (22q11.2DS) and place this in the context of other genetic forms of PNH. Read More

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http://doi.wiley.com/10.1002/acn3.641
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http://dx.doi.org/10.1002/acn3.641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243376PMC
November 2018
19 Reads

Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine.

Transl Psychiatry 2018 11 14;8(1):247. Epub 2018 Nov 14.

Neuroscience Institute, New York University Medical Center, New York, NY, USA.

The 22q11.2 deletion syndrome (22q11.2DS) confers high risk of neurodevelopmental disorders such as schizophrenia and attention-deficit hyperactivity disorder. Read More

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http://www.nature.com/articles/s41398-018-0295-3
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http://dx.doi.org/10.1038/s41398-018-0295-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235862PMC
November 2018
13 Reads

Review: Fluid biomarkers for frontotemporal dementias.

Neuropathol Appl Neurobiol 2019 Feb 3;45(1):81-87. Epub 2018 Dec 3.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Frontotemporal dementias (FTDs) are clinically, genetically and pathologically heterogeneous neurodegenerative disorders that affect the frontal and anterior temporal lobes of the brain. They are relatively common causes of young-onset dementia and usually present with behavioural disturbance (behavioural variant FTD) or language impairment (primary progressive aphasia), but there is also overlap with motor neurone disease and the atypical parkinsonian disorders, corticobasal syndrome and progressive supranuclear palsy. At post mortem, neuronal inclusions containing tau, TDP-43 or infrequently FUS protein are seen in most cases. Read More

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http://doi.wiley.com/10.1111/nan.12530
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http://dx.doi.org/10.1111/nan.12530DOI Listing
February 2019
17 Reads

Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.

J Neural Transm (Vienna) 2019 Feb 31;126(2):123-129. Epub 2018 Oct 31.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Persistent postural-perceptual dizziness (PPPD) is a recently defined syndrome with chronic dizziness interrupting daily life. Although the high levels of anxiety and functional changes in postural control strategy and multi-sensory information processing and integration may be underlying the pathophysiology, its neural mechanisms are poorly understood. The aim of this study was to examine the regional cerebral blood flow (rCBF) in patients with PPPD using single photon emission computed tomography (SPECT). Read More

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http://link.springer.com/10.1007/s00702-018-1948-3
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http://dx.doi.org/10.1007/s00702-018-1948-3DOI Listing
February 2019
6 Reads

No association between cardiometabolic risk and neural reactivity to acute psychosocial stress.

Neuroimage Clin 2018 22;20:1115-1122. Epub 2018 Oct 22.

Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, J5, 68159 Mannheim, Germany. Electronic address:

Background: Exaggerated reactivity to acute psychosocial stress is associated with an increased risk of cardiovascular and metabolic disease. A dysfunction of the cortico-limbic network coordinating the peripheral adaptation to acute stress exposure may constitute a brain mechanism underlying this association. We opted to characterize the changes of this network associated with acute psychosocial stress exposure in individuals with low and high cardiometabolic risk (CMR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183032
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http://dx.doi.org/10.1016/j.nicl.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205354PMC
February 2019
13 Reads

Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation.

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0996DOI Listing
October 2018
7 Reads

The Edinburgh Cognitive and Behavioral ALS screen: relationship to age, education, IQ and the Addenbrooke's Cognitive Examination-III.

Amyotroph Lateral Scler Frontotemporal Degener 2018 Nov 29;19(7-8):585-590. Epub 2018 Oct 29.

a Human Cognitive Neuroscience - Department of Psychology , The University of Edinburgh , Edinburgh , UK.

The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) was developed to assess cognitive and behavioral changes common in Amyotrophic Lateral Sclerosis and other diseases affecting motor functions. It focuses on domains typically affected by the frontotemporal syndrome (executive and language functions, fluency and behavior), but assesses also memory and visuospatial functions.

Objectives: (A) To investigate the relationship between the ECAS and the Addenbrooke's Cognitive Examination (ACE-III). Read More

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http://dx.doi.org/10.1080/21678421.2018.1491601DOI Listing
November 2018
14 Reads

Changes in recruitment of motor cortex excitation and inhibition in patients with drug-induced tardive syndromes.

Neurophysiol Clin 2019 Feb 23;49(1):33-40. Epub 2018 Oct 23.

Sobell Department of Motor Neuroscience and movement Disorders, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Objectives: It has recently been suggested that drug-induced tardive syndromes (TS) might be due to maladaptive plasticity, which increases motor excitability in cerebral cortex and basal ganglia. In order to test this hypothesis, we performed the first measurements of cortical excitability in TS.

Methods: Motor cortex excitability was examined using transcranial magnetic stimulation (TMS) in 22 TS patients and compared with that in 20 age and sex-matched healthy individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09877053183021
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http://dx.doi.org/10.1016/j.neucli.2018.10.001DOI Listing
February 2019
17 Reads

Predicting progression in the late onset frontal lobe syndrome.

Int Psychogeriatr 2018 Oct 26:1-6. Epub 2018 Oct 26.

Department of Old Age Psychiatry,GGZinGeest/VU University Medical Center,Amsterdam,the Netherlands.

ABSTRACTA late onset frontal lobe syndrome (LOF) refers to a clinical syndrome with apathy, disinhibition, or stereotypical behavior arising in middle or late adulthood. Diagnostics are challenging, and both clinicians and patients need reliable predictors of progression to improve clinical guidance. In this longitudinal multicenter and genetically screened prospective study, 137 LOF patients with frontal behavior (FBI score≥11) and/or stereotypical behavior (SRI≥10) were included. Read More

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http://dx.doi.org/10.1017/S1041610218001242DOI Listing
October 2018
20 Reads

A critical review of the role of impaired spatial remapping processes in spatial neglect.

Clin Neuropsychol 2018 Oct 25:1-23. Epub 2018 Oct 25.

a Department of Neurosciences , University of Geneva , Geneva , Switzerland.

Objective: Unilateral spatial neglect is a multi-faceted syndrome that arises from brain lesions, typically in the right hemisphere, and is characterized by the failure to attend or respond to stimuli in contralesional space. Here, we expand on the proposal that one deficit contributing to the diverse symptoms in neglect involves spatial remapping processes. Spatial remapping is required to maintain a stable visual representation despite frequent eye movements that change the retinal image. Read More

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http://dx.doi.org/10.1080/13854046.2018.1503722DOI Listing
October 2018
9 Reads

Acute hemiparesis and status epilepticus following endoscopic esophageal balloon dilation: is it really a stroke?

Clin J Gastroenterol 2019 Apr 20;12(2):171-175. Epub 2018 Oct 20.

Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.

A 68-year-old gentleman was referred for elective upper gastrointestinal endoscopy on a background of dysphagia and esophageal candidiasis. A benign peptic stricture was noted, managed with balloon dilation without apparent immediate complication. At completion, however, the patient became confused and agitated, with no improvement despite the reversal of sedation. Read More

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http://link.springer.com/10.1007/s12328-018-0916-7
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http://dx.doi.org/10.1007/s12328-018-0916-7DOI Listing
April 2019
19 Reads

Analysis of first-episode and chronic schizophrenia using multi-modal magnetic resonance imaging.

Eur Rev Med Pharmacol Sci 2018 Oct;22(19):6422-6435

Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital, Guangzhou Mental Health Center), Guangzhou, China.

Objective: The brain structure and function differences among first-episode schizophrenia (FESZ) patients, chronic schizophrenia (CSZ) patients, and normal control (NC) subjects were investigated using structural and functional magnetic resonance imaging (MRI). Also, a support vector machine (SVM) combined with recursive feature elimination (RFE) was used for classification.

Patients And Methods: First, 44 FESZ patients, 44 CSZ patients, and 56 NC subjects were recruited, and structural MRI images were acquired. Read More

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http://dx.doi.org/10.26355/eurrev_201810_16055DOI Listing
October 2018
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Downregulation of mGluR2/3 receptors during morphine withdrawal in rats impairs mGluR2/3- and NMDA receptor-dependent long-term depression in the nucleus accumbens.

Neurosci Lett 2019 01 11;690:76-82. Epub 2018 Oct 11.

Key Laboratory of Modern Teaching Technology, Ministry of Education, Shaanxi Normal University, Xi'an, Shaanxi, 710062, PR China. Electronic address:

Drugs of abuse modify synaptic long-term potentiation and long-term depression (LTD) in the nucleus accumbens, and the impairment of synaptic plasticity in this brain region may be a universal feature of drug addiction. It is unknown whether metabotropic glutamate receptors (mGluRs) play a role in synaptic plasticity induced by drugs such as morphine. The neurochemical, electrophysiological, and Western blotting experiments reported here reveal a novel form of LTD in synapses of the shell region of the nucleus accumbens induced in vivo by low-frequency stimulation of the medial prefrontal cortex. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183069
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http://dx.doi.org/10.1016/j.neulet.2018.10.018DOI Listing
January 2019
5 Reads

A case report of isolated distal upper extremity weakness due to cerebral metastasis involving the hand knob area.

BMC Cancer 2018 Oct 3;18(1):947. Epub 2018 Oct 3.

Department of Neurology, Semmelweis University, Balassa u. 6., H- 1083, Budapest, Hungary.

Background: Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of these, most frequently caused by a small lesion in the contralateral motor cortex of the brain. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4857-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171188PMC
October 2018
9 Reads

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.

Eur J Nucl Med Mol Imaging 2019 02 29;46(2):385-395. Epub 2018 Sep 29.

Faculty of Medicine, Geneva University, 1211, Geneva, Switzerland.

Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.

Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. Read More

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http://link.springer.com/10.1007/s00259-018-4175-0
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http://dx.doi.org/10.1007/s00259-018-4175-0DOI Listing
February 2019
7 Reads

Objective Ocular Discomfort: Noninvasive Evaluation by Functional Near-Infrared Ray Spectroscopy.

Invest Ophthalmol Vis Sci 2018 09;59(11):4683-4690

Tokai University Junior College of Nursing and Medical Technologies, Hiratsuka, Japan.

Purpose: Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography.

Methods: This case-controlled study enrolled six dry eye patients (male:female, 1:1; 51. Read More

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https://iovs.arvojournals.org/article.aspx?articleid=2704863
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https://jov.arvojournals.org/article.aspx?articleid=2589491
Web Search
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-24840DOI Listing
September 2018
8 Reads

Effect of acoustic stimuli in patients with disorders of consciousness: a quantitative electroencephalography study.

Neural Regen Res 2018 Nov;13(11):1900-1906

Department of Neurology & Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Read More

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http://dx.doi.org/10.4103/1673-5374.238622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183039PMC
November 2018
2 Reads

Psychiatric disorders associated with acquired brain pathology.

Authors:
Alfredo Ardila

Appl Neuropsychol Adult 2018 Sep 5:1-7. Epub 2018 Sep 5.

a Department of Communication Sciences and Disorders , Florida International University , Miami , Florida , USA.

Acquired brain pathology can be associated with diverse psychiatric manifestations. Three major types of psychiatric disorders potentially found in cases of acquired brain pathology are examined: (1) psychosis, (2) mood disorders, and (3) personality disorders with special emphasis in so-called "acquired psychopathy." Two types of psychotic manifestations are reviewed: (a) Schizophrenia-like psychosis; (b) Other delusional disorder, specifically, somatoparaphrenia and delusional misidentification syndromes, which include reduplicative paramnesias, Capgras syndrome, Frégoli syndrome, and "doubles of the self-syndrome. Read More

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https://www.tandfonline.com/doi/full/10.1080/23279095.2018.1
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http://dx.doi.org/10.1080/23279095.2018.1463224DOI Listing
September 2018
11 Reads

[F]fluorodeoxyglucose-positron emission tomography study of genetically confirmed patients with Dravet syndrome.

Epilepsy Res 2018 11 27;147:9-14. Epub 2018 Aug 27.

Department of Pediatrics, Tohoku University School of Medicine, Sendai 980-8574, Japan.

Objective: To understand cerebral brain dysfunction in patients with Dravet syndrome (DS), we conducted a [F]fluorodeoxyglucose-positron emission tomography (FDG-PET) study in patients with DS whose SCN1A gene variant was confirmed.

Methods: FDG-PET was performed on eight patients with DS. A SCN1A mutation analysis revealed missense variants in four patients and truncation variants in four patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.008DOI Listing
November 2018
25 Reads