4,840 results match your criteria Frontal Lobe Syndromes


Change of Cerebral Blood Flow After a Successful Pharmacological Treatment of Phantom Bite Syndrome: A Case Report.

Clin Neuropharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychosomatic Dentistry and.

Background: "Phantom bite syndrome," a persistent complaint of an uncomfortable bite sensation with no obvious occlusal abnormal finding, recently was suggested to be related with central nervous system dysfunction. Here, we report a case of phantom bite syndrome in which the occlusal discomfort was improved with mirtazapine and aripiprazole combination parallel with regional cerebral blood flow change.

Case Report: A 60-year-old-female patient came to our clinic with the chief complaint of a "loosely bite" after dental treatment and various uncomfortable sensations of body sites. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000328DOI Listing
February 2019

Role of Frontal Functions in Executing Routine Sequential Tasks.

Front Psychol 2019 6;10:169. Epub 2019 Feb 6.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.

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http://dx.doi.org/10.3389/fpsyg.2019.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372513PMC
February 2019

DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019
1 Read

Recovery time from supplementary motor area syndrome: relationship to postoperative day 7 paralysis and damage of the cingulum.

J Neurosurg 2019 Feb 8:1-10. Epub 2019 Feb 8.

2Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; and.

OBJECTIVESupplementary motor area (SMA) syndrome is defined as temporary paralysis after the resection of brain tumor localized in the SMA. Although in most cases paralysis induced by SMA resection resolves within a short period, the time until complete recovery varies and has not been precisely analyzed to date. In this study, the authors investigated factors for predicting the time required for recovery from paralysis after SMA resection. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182391DOI Listing
February 2019

Atypical posterior reversible encephalopathy syndrome in a noncompliant hemodialysis patient: Case report and literature review.

Hemodial Int 2019 Feb 8. Epub 2019 Feb 8.

Division of Neurology, Department of Medicine, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan.

Posterior reversible encephalopathy syndrome (PRES) is a reversible vasogenic brain edema in patients who present with seizure, headache, visual disturbance, and altered mental status, and a characteristic neuroimaging profile. Although PRES predominantly affects the bilateral parieto-occipital areas, involvement of the frontal and temporal lobes, basal ganglia, brainstem, and cerebellum is not uncommon. Isolated involvement of the brainstem and cerebellum sparing the parieto-occipital lobe is rarely reported. Read More

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http://doi.wiley.com/10.1111/hdi.12735
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http://dx.doi.org/10.1111/hdi.12735DOI Listing
February 2019
1 Read

Behavioural changes as the first manifestation of a silent frontal lobe stroke.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Intensive Care Medicine, Hospital Universitario de Mostoles, Mostoles, Spain.

A 67-year-old man was admitted to our hospital after his relatives found him to have severe personality and behavioural changes. His behaviour was inappropriate and uninhibited. The patient reported no symptoms and he showed poor insight into his own behaviour. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22761
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http://dx.doi.org/10.1136/bcr-2018-227617DOI Listing
January 2019
8 Reads

Posterior Reversible Encephalopathy Syndrome with Stroke in Puerperal Woman with High Titer of Anti-Phospholipid IgM Antibody.

Case Rep Obstet Gynecol 2018 3;2018:7438676. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.

Posterior reversible encephalopathy syndrome with stroke is very rare in puerperal women. A 36-year-old nulliparous woman with both rheumatoid arthritis and recurrent pregnancy loss, probably due to a high titer of anti-phospholipid IgM antibody, was referred at 10 weeks of gestation. Low-dose aspirin at 100 mg/day and heparin calcium subcutaneous injection at 10,000 units/day were started before pregnancy and stopped at 35 and 40 weeks, respectively. Read More

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https://www.hindawi.com/journals/criog/2018/7438676/
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http://dx.doi.org/10.1155/2018/7438676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304583PMC
December 2018
5 Reads

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods.

Epilepsy Behav Case Rep 2019 1;11:39-42. Epub 2018 Nov 1.

Brno Epilepsy Centre, Department of Paediatric Neurology, University Hospital, Masaryk University, Brno, Czech Republic.

Purpose: Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313257PMC
November 2018
12 Reads

Alterations of Graphic Properties and Related Cognitive Functioning Changes in Mild Alzheimer's Disease Revealed by Individual Morphological Brain Network.

Front Neurosci 2018 10;12:927. Epub 2018 Dec 10.

Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Alzheimer's disease (AD) is one of the most common forms of dementia that has slowly negative impacts on memory and cognition. With the assistance of multimodal brain networks and graph-based analysis approaches, AD-related network disruptions support the hypothesis that AD can be identified as a dysconnectivity syndrome. However, as the recent emerging of individual-based morphological network research of AD, the utilization of multiple morphometric features may provide a broader horizon for locating the lesions. Read More

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http://dx.doi.org/10.3389/fnins.2018.00927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295573PMC
December 2018
2 Reads

Neuro-Behçet's disease presenting as an isolated progressive cognitive and behavioral syndrome.

Neurocase 2018 Dec 25:1-4. Epub 2018 Dec 25.

a Second Division of Neurology , Center for Rare Neurological and Neuromuscular Diseases & Inter University Center for Research in Neurosciences, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli , Naples , Italy.

Behçet's disease is a chronic inflammatory disorder manifesting as a vasculitis that affects arteries and veins of any size. Up to 44% of cases may also present with neurological symptoms, thus defining Neuro-Behçet's disease. We describe a case of Neuro-Behçet's disease characterized by progressive behavioral and cognitive deterioration prevailing over other neurological symptoms, without evident systemic involvement. Read More

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http://dx.doi.org/10.1080/13554794.2018.1561898DOI Listing
December 2018

Common findings on head computed tomography in neonates with confirmed congenital Zika syndrome.

Radiol Bras 2018 Nov-Dec;51(6):366-371

Hospital Barão de Lucena (HBL), Recife, PE, Brazil.

Objective: To describe head computed tomography (CT) findings in neonates with congenital Zika virus infection confirmed in cerebrospinal fluid.

Materials And Methods: This was a study of 16 newborn infants who exhibited abnormal head CT findings during an outbreak of Zika virus infection. Those infants had the following features: brain imaging suggestive of congenital infection; brain calcifications and negative results on tests for other main infectious causes of primary microcephaly, namely toxoplasmosis, cytomegalovirus, rubella, and HIV; positivity for Zika virus on IgM antibody capture enzyme-linked immunosorbent assay in cerebrospinal fluid. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2017.0119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290748PMC
December 2018
7 Reads

Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging.

Radiol Case Rep 2019 Mar 5;14(3):309-314. Epub 2018 Dec 5.

Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania "Luigi Vanvitelli", Via Sergio Pansini, 80131 Naples, Italy.

X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease affecting the nervous system and the adrenal glands. It is caused by a mutation of the gene, resulting in the impaired degradation of very long-chain fatty acids and their subsequent accumulation in several organs and tissues. X-ALD is notable for its high phenotypical variability, that includes isolated adrenocortical insufficiency, slowly progressive myelopathy with paraparesis, ataxia, and peripheral neuropathy to severe childhood cerebral forms. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282458PMC
March 2019
1 Read

Posterior reversible encephalopathy syndrome.

Curr Opin Neurol 2019 Feb;32(1):25-35

Center for Stroke Research Berlin (CSB).

Purpose Of Review: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by acute cerebral endotheliopathy with consecutive disruption of the blood-brain barrier and vasogenic edema. Since its first description in 1996, PRES is increasingly recognized. However, many aspects of this syndrome with its wide spectrum of clinical and radiological features are still incompletely understood. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000640DOI Listing
February 2019
2 Reads

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec;20(6):490-501

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1014DOI Listing
December 2018
2 Reads

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec;20(6):457-467

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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http://dx.doi.org/10.1684/epd.2018.1009DOI Listing
December 2018
3 Reads

Carotid Artery Stenting for Symptomatic Internal Carotid Artery Stenosis Associated with Moyamoya Syndrome.

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawaramachi, Shogoin, Sakyo-ku, Kyoto City, Kyoto 606-8507, JAPAN.

Background: The surgical intervention in a case of internal carotid artery stenosis with Moyamoya vessels has not been well described. We present such a case with detailed description about its procedure and perioperative management.

Case Description: A 58-year-old man with symptomatic internal carotid artery stenosis had concurrent moyamoya vessels intracranially. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.204DOI Listing
December 2018
2 Reads

Paraneoplastic syndrome or metastatic sinonasal neuroendocrine carcinoma? Clinical conundrum.

Ear Nose Throat J 2018 Oct-Nov;97(10-11):E15-E18

Department of Neurosurgery, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.

We report a case of a middle-aged woman with a diffuse, nonenhancing, progressively atrophic T2-hyperintense lesion involving the left frontotemporal lobes and insula found to be synchronous high-grade sinonasal neuroendocrine carcinoma (SNEC) after initial endonasal resection. In 2014, a 47-year old woman underwent resection of a left-sided high-grade ethmoidal neuroendocrine carcinoma after presentation with weight gain and increased levels of serum and urine cortisol. Concurrent with the initial presentation, she was noted to have a nonenhancing, hyperintense signal change on T2-weighted images on the left frontotemporal lobes and insula thought to be paraneoplastic. Read More

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November 2018
11 Reads
0.881 Impact Factor

Periventricular nodular heterotopia in 22q11.2 deletion and frontal lobe migration.

Ann Clin Transl Neurol 2018 Nov 23;5(11):1314-1322. Epub 2018 Sep 23.

Division of Neurology Department of Medicine Krembil Neuroscience Centre Toronto Western Hospital University of Toronto Toronto Ontario Canada.

Objective: We aimed to delineate the distribution of periventricular nodular heterotopia (PNH) in patients with 22q11.2 microdeletion syndrome (22q11.2DS) and place this in the context of other genetic forms of PNH. Read More

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http://doi.wiley.com/10.1002/acn3.641
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http://dx.doi.org/10.1002/acn3.641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243376PMC
November 2018
14 Reads

Review: Fluid biomarkers for frontotemporal dementias.

Neuropathol Appl Neurobiol 2019 Feb 3;45(1):81-87. Epub 2018 Dec 3.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Frontotemporal dementias (FTDs) are clinically, genetically and pathologically heterogeneous neurodegenerative disorders that affect the frontal and anterior temporal lobes of the brain. They are relatively common causes of young-onset dementia and usually present with behavioural disturbance (behavioural variant FTD) or language impairment (primary progressive aphasia), but there is also overlap with motor neurone disease and the atypical parkinsonian disorders, corticobasal syndrome and progressive supranuclear palsy. At post mortem, neuronal inclusions containing tau, TDP-43 or infrequently FUS protein are seen in most cases. Read More

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http://doi.wiley.com/10.1111/nan.12530
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http://dx.doi.org/10.1111/nan.12530DOI Listing
February 2019
11 Reads

Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.

J Neural Transm (Vienna) 2019 Feb 31;126(2):123-129. Epub 2018 Oct 31.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Persistent postural-perceptual dizziness (PPPD) is a recently defined syndrome with chronic dizziness interrupting daily life. Although the high levels of anxiety and functional changes in postural control strategy and multi-sensory information processing and integration may be underlying the pathophysiology, its neural mechanisms are poorly understood. The aim of this study was to examine the regional cerebral blood flow (rCBF) in patients with PPPD using single photon emission computed tomography (SPECT). Read More

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http://link.springer.com/10.1007/s00702-018-1948-3
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http://dx.doi.org/10.1007/s00702-018-1948-3DOI Listing
February 2019
5 Reads

No association between cardiometabolic risk and neural reactivity to acute psychosocial stress.

Neuroimage Clin 2018 22;20:1115-1122. Epub 2018 Oct 22.

Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, J5, 68159 Mannheim, Germany. Electronic address:

Background: Exaggerated reactivity to acute psychosocial stress is associated with an increased risk of cardiovascular and metabolic disease. A dysfunction of the cortico-limbic network coordinating the peripheral adaptation to acute stress exposure may constitute a brain mechanism underlying this association. We opted to characterize the changes of this network associated with acute psychosocial stress exposure in individuals with low and high cardiometabolic risk (CMR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183032
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http://dx.doi.org/10.1016/j.nicl.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205354PMC
February 2019
10 Reads

Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation.

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0996DOI Listing
October 2018
2 Reads

The Edinburgh Cognitive and Behavioral ALS screen: relationship to age, education, IQ and the Addenbrooke's Cognitive Examination-III.

Amyotroph Lateral Scler Frontotemporal Degener 2018 Nov 29;19(7-8):585-590. Epub 2018 Oct 29.

a Human Cognitive Neuroscience - Department of Psychology , The University of Edinburgh , Edinburgh , UK.

The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) was developed to assess cognitive and behavioral changes common in Amyotrophic Lateral Sclerosis and other diseases affecting motor functions. It focuses on domains typically affected by the frontotemporal syndrome (executive and language functions, fluency and behavior), but assesses also memory and visuospatial functions.

Objectives: (A) To investigate the relationship between the ECAS and the Addenbrooke's Cognitive Examination (ACE-III). Read More

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http://dx.doi.org/10.1080/21678421.2018.1491601DOI Listing
November 2018
13 Reads

Predicting progression in the late onset frontal lobe syndrome.

Int Psychogeriatr 2018 Oct 26:1-6. Epub 2018 Oct 26.

Department of Old Age Psychiatry,GGZinGeest/VU University Medical Center,Amsterdam,the Netherlands.

ABSTRACTA late onset frontal lobe syndrome (LOF) refers to a clinical syndrome with apathy, disinhibition, or stereotypical behavior arising in middle or late adulthood. Diagnostics are challenging, and both clinicians and patients need reliable predictors of progression to improve clinical guidance. In this longitudinal multicenter and genetically screened prospective study, 137 LOF patients with frontal behavior (FBI score≥11) and/or stereotypical behavior (SRI≥10) were included. Read More

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http://dx.doi.org/10.1017/S1041610218001242DOI Listing
October 2018
11 Reads

A critical review of the role of impaired spatial remapping processes in spatial neglect.

Clin Neuropsychol 2018 Oct 25:1-23. Epub 2018 Oct 25.

a Department of Neurosciences , University of Geneva , Geneva , Switzerland.

Objective: Unilateral spatial neglect is a multi-faceted syndrome that arises from brain lesions, typically in the right hemisphere, and is characterized by the failure to attend or respond to stimuli in contralesional space. Here, we expand on the proposal that one deficit contributing to the diverse symptoms in neglect involves spatial remapping processes. Spatial remapping is required to maintain a stable visual representation despite frequent eye movements that change the retinal image. Read More

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http://dx.doi.org/10.1080/13854046.2018.1503722DOI Listing
October 2018
9 Reads

Acute hemiparesis and status epilepticus following endoscopic esophageal balloon dilation: is it really a stroke?

Clin J Gastroenterol 2018 Oct 20. Epub 2018 Oct 20.

Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.

A 68-year-old gentleman was referred for elective upper gastrointestinal endoscopy on a background of dysphagia and esophageal candidiasis. A benign peptic stricture was noted, managed with balloon dilation without apparent immediate complication. At completion, however, the patient became confused and agitated, with no improvement despite the reversal of sedation. Read More

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http://link.springer.com/10.1007/s12328-018-0916-7
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http://dx.doi.org/10.1007/s12328-018-0916-7DOI Listing
October 2018
12 Reads

Analysis of first-episode and chronic schizophrenia using multi-modal magnetic resonance imaging.

Eur Rev Med Pharmacol Sci 2018 Oct;22(19):6422-6435

Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital, Guangzhou Mental Health Center), Guangzhou, China.

Objective: The brain structure and function differences among first-episode schizophrenia (FESZ) patients, chronic schizophrenia (CSZ) patients, and normal control (NC) subjects were investigated using structural and functional magnetic resonance imaging (MRI). Also, a support vector machine (SVM) combined with recursive feature elimination (RFE) was used for classification.

Patients And Methods: First, 44 FESZ patients, 44 CSZ patients, and 56 NC subjects were recruited, and structural MRI images were acquired. Read More

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http://dx.doi.org/10.26355/eurrev_201810_16055DOI Listing
October 2018
1 Read

A case report of isolated distal upper extremity weakness due to cerebral metastasis involving the hand knob area.

BMC Cancer 2018 Oct 3;18(1):947. Epub 2018 Oct 3.

Department of Neurology, Semmelweis University, Balassa u. 6., H- 1083, Budapest, Hungary.

Background: Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of these, most frequently caused by a small lesion in the contralateral motor cortex of the brain. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4857-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171188PMC
October 2018
7 Reads

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.

Eur J Nucl Med Mol Imaging 2019 02 29;46(2):385-395. Epub 2018 Sep 29.

Faculty of Medicine, Geneva University, 1211, Geneva, Switzerland.

Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.

Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. Read More

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http://link.springer.com/10.1007/s00259-018-4175-0
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http://dx.doi.org/10.1007/s00259-018-4175-0DOI Listing
February 2019
4 Reads

Effect of acoustic stimuli in patients with disorders of consciousness: a quantitative electroencephalography study.

Neural Regen Res 2018 Nov;13(11):1900-1906

Department of Neurology & Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Read More

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http://dx.doi.org/10.4103/1673-5374.238622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183039PMC
November 2018
2 Reads

Psychiatric disorders associated with acquired brain pathology.

Authors:
Alfredo Ardila

Appl Neuropsychol Adult 2018 Sep 5:1-7. Epub 2018 Sep 5.

a Department of Communication Sciences and Disorders , Florida International University , Miami , Florida , USA.

Acquired brain pathology can be associated with diverse psychiatric manifestations. Three major types of psychiatric disorders potentially found in cases of acquired brain pathology are examined: (1) psychosis, (2) mood disorders, and (3) personality disorders with special emphasis in so-called "acquired psychopathy." Two types of psychotic manifestations are reviewed: (a) Schizophrenia-like psychosis; (b) Other delusional disorder, specifically, somatoparaphrenia and delusional misidentification syndromes, which include reduplicative paramnesias, Capgras syndrome, Frégoli syndrome, and "doubles of the self-syndrome. Read More

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https://www.tandfonline.com/doi/full/10.1080/23279095.2018.1
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http://dx.doi.org/10.1080/23279095.2018.1463224DOI Listing
September 2018
11 Reads

[F]fluorodeoxyglucose-positron emission tomography study of genetically confirmed patients with Dravet syndrome.

Epilepsy Res 2018 11 27;147:9-14. Epub 2018 Aug 27.

Department of Pediatrics, Tohoku University School of Medicine, Sendai 980-8574, Japan.

Objective: To understand cerebral brain dysfunction in patients with Dravet syndrome (DS), we conducted a [F]fluorodeoxyglucose-positron emission tomography (FDG-PET) study in patients with DS whose SCN1A gene variant was confirmed.

Methods: FDG-PET was performed on eight patients with DS. A SCN1A mutation analysis revealed missense variants in four patients and truncation variants in four patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.008DOI Listing
November 2018
19 Reads

The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory.

Neuropharmacology 2018 10 27;141:113-125. Epub 2018 Aug 27.

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA. Electronic address:

Epigenetic remodeling contributes to synaptic plasticity via modification of gene expression, which underlies cocaine-induced long-term memory. A prevailing hypothesis in drug addiction is that drugs of abuse rejuvenate developmental machinery to render reward circuitry highly plastic and thus engender drug memories to be highly stable. Identification and reversal of these pathological pathways are therefore critical for cocaine abuse treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183057
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http://dx.doi.org/10.1016/j.neuropharm.2018.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170674PMC
October 2018
7 Reads

Activation of Phosphotyrosine-Mediated Signaling Pathways in the Cortex and Spinal Cord of SOD1, a Mouse Model of Familial Amyotrophic Lateral Sclerosis.

Neural Plast 2018 5;2018:2430193. Epub 2018 Aug 5.

National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Degeneration of cortical and spinal motor neurons is the typical feature of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease for which a pathogenetic role for the Cu/Zn superoxide dismutase (SOD1) has been demonstrated. Mice overexpressing a mutated form of the SOD1 gene (SOD1) develop a syndrome that closely resembles the human disease. The SOD1 mutations confer to this enzyme a "gain-of-function," leading to increased production of reactive oxygen species. Read More

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http://dx.doi.org/10.1155/2018/2430193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098854PMC
December 2018
8 Reads

Sporadic Creutzfeldt-Jakob disease with glial PrP nuclear and perinuclear immunoreactivity.

Neuropathology 2018 Oct 19;38(5):561-567. Epub 2018 Aug 19.

Biomedical Research Institute of Bellvitge (IDIBELL), Hospitalet de Llobregat, Spain.

Proteinase K-resistant prion protein (PrP ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Read More

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http://doi.wiley.com/10.1111/neup.12505
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http://dx.doi.org/10.1111/neup.12505DOI Listing
October 2018
10 Reads
1.800 Impact Factor

Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS.

Neuropharmacology 2018 10 13;141:55-65. Epub 2018 Aug 13.

Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

The HIV-1 transactivator of transcription (Tat) is a neurotoxin involved in the pathogenesis of HIV-1 associated neurocognitive disorders (HAND). The neurotoxic effects of Tat are mediated directly via AMPA/NMDA receptor activity and indirectly through neuroinflammatory signaling in glia. Emerging strategies in the development of neuroprotective agents involve the modulation of the endocannabinoid system. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296377PMC
October 2018
12 Reads

Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome.

eNeuro 2018 May-Jun;5(3). Epub 2018 Aug 10.

Department of Neurology, Brigham and Women's Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, MA 02115.

duplication syndrome is an X-linked form of syndromic autism caused by genomic duplication of the region encoding methyl-CpG-binding protein 2 (MECP2). Mice overexpressing demonstrate social impairment, behavioral inflexibility, and altered patterns of learning and memory. Previous work showed abnormally increased stability of dendritic spines formed during motor training in the apical tuft of primary motor cortex (area M1) corticospinal neurons in the MECP2 duplication mouse model. Read More

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http://dx.doi.org/10.1523/ENEURO.0056-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086213PMC
January 2019
1 Read

Disease trajectories in behavioural variant frontotemporal dementia, primary psychiatric and other neurodegenerative disorders presenting with behavioural change.

J Psychiatr Res 2018 Sep 1;104:183-191. Epub 2018 Aug 1.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdan UMC, Amsterdam, the Netherlands.

Behavioural variant frontotemporal dementia (bvFTD) is characterized by behavioural and social cognitive disturbances, while various psychiatric and neurodegenerative disorders may have similar clinical symptoms. Since neurodegenerative disorders are eventually progressive, whereas primary psychiatric disorders are not, this study aimed to investigate whether the change in clinical symptoms over time differed between groups and which biomarkers predicted rate of decline. Disease trajectories (median follow-up = 3 years) of frontal and stereotyped behaviour, general and frontal cognitive functioning, and social cognition were examined in bvFTD (n = 34), other neurodegenerative (n = 28) and primary psychiatric disorders (n = 43), all presenting with late-onset frontal lobe syndrome (45-75 years), using linear mixed models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183050
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http://dx.doi.org/10.1016/j.jpsychires.2018.07.014DOI Listing
September 2018
27 Reads

The landscape of epilepsy-related GATOR1 variants.

Genet Med 2019 Feb 10;21(2):398-408. Epub 2018 Aug 10.

Sorbonne Université, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France.

Purpose: To define the phenotypic and mutational spectrum of epilepsies related to DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator of the mTORC1 pathway METHODS: We analyzed clinical and genetic data of 73 novel probands (familial and sporadic) with epilepsy-related variants in GATOR1-encoding genes and proposed new guidelines for clinical interpretation of GATOR1 variants.

Results: The GATOR1 seizure phenotype consisted mostly in focal seizures (e.g. Read More

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http://www.nature.com/articles/s41436-018-0060-2
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http://dx.doi.org/10.1038/s41436-018-0060-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292495PMC
February 2019
16 Reads

Frontal lobe executive dysfunction and cerebral perfusion study in alcohol dependence syndrome.

Ind Psychiatry J 2017 Jul-Dec;26(2):134-139

Department of Nuclear Medicine, Army Hospital (R&R), New Delhi, India.

Background: Long-term alcohol use leading to frontal lobe impairment has been a cause of concern for many decades. However, there are very few studies from India of evaluation of frontal lobe executive dysfunction among alcoholics. Hence, this study was undertaken to evaluate the frontal executive dysfunction using Wisconsin Card Sorting Test (WCST) and perfusion deficits by Single-Photon Emission Computerized Tomography (SPECT) among alcohol-dependent patients. Read More

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http://dx.doi.org/10.4103/ipj.ipj_26_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058449PMC
August 2018
13 Reads

Neurobiological Effects of Binge Drinking Help in Its Detection and Differential Diagnosis from Alcohol Dependence.

Dis Markers 2018 4;2018:5623683. Epub 2018 Jul 4.

Department of Psychiatry, Medical University of Białystok, Plac Brodowicza 1, 16-070 Choroszcz, Poland.

The prevalence of binge drinking in the general population is 3-4 times higher than that of alcohol dependence. Neuroimaging studies show that binge drinking in adolescence impairs brain development and white matter integrity. Regions with reduced functional activity include the limbic system, ventral diencephalon, frontal lobe, and middle and inferior temporal lobes, whereas the right superior frontal and parietal lobes are typically hyperactivated. Read More

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http://dx.doi.org/10.1155/2018/5623683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057287PMC
October 2018
14 Reads

A Case of Rapid Malignant Brain Swelling Subacutely After Reperfusion Therapy for Internal Carotid Artery Occlusion.

World Neurosurg 2018 Oct 25;118:311-315. Epub 2018 Jul 25.

Department of Neurosurgery, Nagasaki Harbor Medical Center, Nagasaki, Japan.

Background: Severe complications after reperfusion therapy for acute major vessel occlusion are not well described. We present an extremely rare case of a patient with rapid malignant brain swelling subacutely after acute ischemic stroke.

Case Description: An 84-year-old man underwent reperfusion therapy for acute left internal carotid artery occlusion; complete reperfusion was achieved. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.151DOI Listing
October 2018
4 Reads

Low-grade neuroepithelial tumor: Unusual presentation in an adult without history of seizures.

Neuropathology 2018 Oct 26;38(5):557-560. Epub 2018 Jul 26.

Pathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.

Low-grade neuroepithelial tumors (LGNT) show a broad histopathological spectrum and may be difficult to classify using current World Health Organization (WHO) criteria. A 57-year-old man came to medical attention because of headaches. The patient medical history was otherwise unremarkable. Read More

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http://doi.wiley.com/10.1111/neup.12504
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http://dx.doi.org/10.1111/neup.12504DOI Listing
October 2018
15 Reads

Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 Dec 26;89(12):1250-1258. Epub 2018 Jul 26.

Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK

Background: The thalamus is a major neural hub, with selective connections to virtually all cortical regions of the brain. The multisystem neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) has pathogenic overlap with frontotemporal dementia, and objective in vivo markers of extra-motor pathological spread are lacking. To better consider the role of the thalamus in neurodegeneration, the present study assessed the integrity of the thalamus and its connectivity to major cortical regions of the brain in a longitudinal manner. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318625DOI Listing
December 2018
10 Reads

The cerebellum and learning of non-motor associations in individuals at clinical-high risk for psychosis.

Neuroimage Clin 2018 24;19:137-146. Epub 2018 Mar 24.

Department of Psychology, Northwestern University, United States; Department of Psychiatry, Northwestern University, United States; Institute of Policy Research, Northwestern University, United States; Department of Medical Social Sciences, Northwestern University, United States; Institute for Innovations in Developmental Sciences, Northwestern University, United States.

The cerebello-thalamo-cortical circuit (CTCC) has been implicated in schizophrenia. However, this work has been limited to structural and functional networks, or behavior, and to date, has not been evaluated in clinical high-risk (CHR) youth, a group at elevated risk for psychosis. Here, we used an innovative learning paradigm known to activate the CTCC (while limiting potential motor confounds) to evaluate CHR and healthy control individuals during functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1016/j.nicl.2018.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051312PMC
January 2019
9 Reads

Bringing order to higher order motor disorders.

J Neurol 2018 Jul 19. Epub 2018 Jul 19.

Institute of Neurology, University College London, 7 Queen Square, London, WC1N 3BG, UK.

Majority of movements in everyday situations are complex and involve volition, planning of the movement and selection of the motor programme, all occurring before movement execution. Higher order motor disorders may be defined as abnormal motor behaviours resulting from disruption of any of the cortical processes that precede execution of the motor act. They are common in patients with neurodegenerative disorders, psychiatric diseases and structural brain lesions. Read More

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http://dx.doi.org/10.1007/s00415-018-8974-9DOI Listing
July 2018
13 Reads

Quantitative and qualitative analysis of ictal vocalization in focal epilepsy syndromes.

Seizure 2018 Aug 11;60:178-183. Epub 2018 Jul 11.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To investigate the frequency, localizing significance, and intensity characteristics of ictal vocalization in different focal epilepsy syndromes.

Methods: Up to four consecutive focal seizures were evaluated in 277 patients with lesional focal epilepsy, excluding isolated auras and subclinical EEG seizure patterns. Vocalization was considered to be present if observed in at least one of the analyzed seizures and not being of speech quality. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.008DOI Listing
August 2018
12 Reads

Cortical markers of cognitive syndromes in amyotrophic lateral sclerosis.

Neuroimage Clin 2018 17;19:675-682. Epub 2018 May 17.

Institute for Advanced Study-IUSS Pavia, Palazzo del Broletto e Piazza Vittoria 15, 27100 Pavia, Italy; IRCCS S. Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy.

Amyotrophic lateral sclerosis (ALS) can be associated with a spectrum of cognitive and behavioural symptoms, but the related patterns of focal cortical atrophy in non-demented ALS patients remain largely unknown. We enrolled 48 non-demented ALS patients and 26 healthy controls for a comprehensive neuropsychological assessment and a magnetic resonance exam. Behavioural and cognitive impairment was defined on the basis of a data-driven multi-domain approach in 21 ALS patients. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046611PMC
January 2019
29 Reads