5,099 results match your criteria Frontal Lobe Syndromes


High diagnostic value of plasma Niemann-Pick type C biomarkers in adults with selected neurological and/or psychiatric disorders.

J Neurol 2020 Jun 26. Epub 2020 Jun 26.

Neurology Department, Reference Center for Lysosomal Diseases, Neurogenetics and Metabolism Unit, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France.

Late-onset Niemann-Pick type C (NP-C) is a rare, underdiagnosed lysosomal disease with neurological manifestations. A specific treatment, miglustat, can stabilize the disease if given early. Recently, three plasma screening biomarkers (PSBs) were developed [cholestane3β,5α,6βtriol (C-triol), 7-ketocholesterol (7-KC), and lysosphingomyelin-509 (LSM-509)], allowing a simpler and quite robust screening of patients suitable for genetic testing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-020-10020-4DOI Listing

Parkinsonian Syndrome with Frontal Lobe Involvement and Anti-Glycine Receptor Antibodies.

Brain Sci 2020 Jun 23;10(6). Epub 2020 Jun 23.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the context of autoimmune encephalitis with antineuronal antibodies, such as anti-glycine receptor (anti-GlyR) antibodies, which are typically associated with Stiff-Person spectrum syndrome, or progressive encephalomyelitis with rigidity and myoclonus. Overlaps between neurodegenerative and immunological mechanisms have been recently suggested in anti-IgLON5 disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/brainsci10060399DOI Listing

Frontal lobe growth is impaired in fetuses with congenital heart disease.

Ultrasound Obstet Gynecol 2020 Jun 23. Epub 2020 Jun 23.

Fetal Medicine and Surgery Unit, Istituto G.Gaslini, Genoa, Italy.

Objective: The primary objective of this study is to assess whether foetuses with congenital heart disease (CHD) have smaller frontal brain areas than normal controls. Secondary objective is to evaluate whether there is any difference among CHD with different haemodynamics.

Methods: Retrospective cross-sectional study, including 421 normal foetuses and 101 fetuses with isolated CHD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/uog.22127DOI Listing

Who seizes longest? Impact of clinical and demographic factors.

Epilepsia 2020 Jun 21. Epub 2020 Jun 21.

Department of Neurology, Epilepsy Center, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: To investigate the impact of clinical and demographic parameters on the duration of focal onset seizures with and without secondary generalization using precise duration measurements from intracranial electroencephalographic (iEEG) recordings.

Methods: Patients with unifocal epilepsy syndromes and iEEG recording were retrospectively identified from the database of the local epilepsy center (2006-2016). Seizure duration was defined as time difference of iEEG seizure pattern onset and cessation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.16577DOI Listing

The Association between Post-Cardiac Arrest Cerebral Oxygenation and Survival with Favorable Neurological Outcomes: A Multicenter Study.

Resuscitation 2020 Jun 13. Epub 2020 Jun 13.

New York University, New York, NY, United States.

Objective: Cerebral oximetry is a non-invasive system that uses near infrared spectroscopy to measure regional cerebral oxygenation (rSO) in the frontal lobe of the brain. Post-cardiac arrest rSO may be associated with survival and neurological outcomes in out-of-hospital cardiac arrest patients; however, no studies have examined relationships between rSO and neurological outcomes following in-hospital cardiac arrest (IHCA). We tested the hypothesis that rSO following IHCA is associated with survival and favorable neurological outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resuscitation.2020.06.006DOI Listing

Catching the imposter in the brain: The case of Capgras delusion.

Cortex 2020 May 19. Epub 2020 May 19.

CNR Neuroscience Institute, Parma, Italy.

Here we describe a rare case of Capgras delusion - a misidentification syndrome characterized by the belief that a person has been replaced by an imposter - in a patient without evident neurological or psychiatric symptoms. Intriguingly, delusional belief was selective for both person and modality, as the patient believed that his son - not his daughter or other relatives - was substituted with an imposter only while being in presence of him and looking at his face, but not when merely listening to his voice. A neuroanatomical reconstruction obtained integrating morphological and functional patient's neuroimaging data highlighted two main peculiarities: a compression of the rostral portion of right temporal lobe due to a large arachnoid cyst, and a bilaterally reduced metabolism of frontal areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cortex.2020.04.025DOI Listing

Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases.

Int J Surg Pathol 2020 Jun 14:1066896920933998. Epub 2020 Jun 14.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China.

. Hemangioblastoma occurs mainly in the cerebellum and rarely in the cerebrum. . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1066896920933998DOI Listing

Sexual Behavioral Disinhibition Associated with Nucleus Lentiformis Lesion: A Forensic Neuroscience Perspective Through a Case.

J Forensic Sci 2020 Jun 11. Epub 2020 Jun 11.

Ministry of Justice, The Council of Forensic Medicine, Istanbul, Turkey.

Organic brain disturbances particularly related to frontal cortex structures and subcortical areas including the basal ganglia may play a role in behavioral disinhibition disorders. Kluver-Bucy syndrome (KBS), which is one of the better knowns of these syndromes, includes hyperorality, visual agnosia, and hypersexuality, has been reported to occur after temporal lobe and amygdala lesions; however, several patients who had focal lesions in areas other than the temporal cortex and amygdala have been reported to present partial KBS symptoms. Nucleus lentiformis refers to a large portion of the basal ganglia including the putamen and globus pallidus, and specific structures within this broad area are known to be important for reward and value-based decision making. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.14477DOI Listing

Acute convexity subarachnoid hemorrhage (cSAH) in infectious endocarditis (IE): imaging features and follow-up.

J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Bichat Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Aim: To assess: (1) the prevalence of convexity subarachnoid hemorrhage (cSAH) in infective endocarditis (IE); (2) its relationship with IE features; (3) the associated lesions; (4) whether cSAH is a predictor of future hemorrhage; (5) whether cSAH could cause cortical superficial siderosis (cSS).

Methods: We retrospectively evaluated the MRI data in 240 IE-patients: At baseline, the location of cSAH and associated lesions; at follow-up, the occurrence of new lesions and of cSS. Patients with and without cSAH were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-020-09953-7DOI Listing

Characteristics of diffusion tensor imaging of central nervous system in children with tourette's disease.

Medicine (Baltimore) 2020 May;99(22):e20492

Department of Radiology.

To investigate the characteristics of diffusion tensor imaging (DTI) of the central nervous system in children with Tourette syndrome (TS).Fifteen children with TS (TS group) and 15 normal children (control group) were studied, and all of them underwent DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) parameters were calculated using the DTIStudio software. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020492DOI Listing

Othello Syndrome Secondary to Cerebral Tuberculoma: A Case Report.

Rev Colomb Psiquiatr 2020 Apr - Jun;49(2):116-120. Epub 2018 Oct 8.

Instituto Nacional de Salud Mental Honorio Delgado-Hideyo Noguchi, Lima, Perú; Universidad Peruana Cayetano Heredia, Lima, Perú. Electronic address:

Introduction: Othello syndrome, an eponym of Shakespeare's character, is a transnosological diagnostic term that designates a clinical picture characterised by the presence of delusions of infidelity with respect to a partner and that, consequently, can lead to typical jealousy attitudes and violent behaviour towards the partner. In its pure form, it corresponds to delusional disorder of infidelity, but it may also be secondary to brain organicity and drug use.

Methods: Case report and non-systematic review of the relevant literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rcp.2018.09.001DOI Listing
October 2018

The Behavioral Neuroscience of Traumatic Brain Injury.

Psychiatr Clin North Am 2020 Jun;43(2):305-330

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Traumatic brain injury is a calamity of various causes, pathologies, and extremely varied and often complex clinical presentations. Because of its predilection for brain systems underlying cognitive and complex behavioral operations, it may cause chronic and severe psychiatric illness that requires expert management. This is more so for the modern epidemic of athletic and military brain injuries which are dominated by psychiatric symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psc.2020.02.009DOI Listing

Mesial Frontal Lobe Infarction Presenting as Pisa Syndrome.

J Stroke Cerebrovasc Dis 2020 May 13:104882. Epub 2020 May 13.

Department of Neurology, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka 410-2295, Japan.

Pisa syndrome is usually seen in patients with Alzheimer's disease treated with a cholinesterase inhibitor, dementia with Lewy bodies, Parkinson's disease, or atypical parkinsonism including multiple system atrophy. An 86-year-old woman presented with an acute onset of lateral flexion of her trunk to the left side, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104882DOI Listing

Characterization of Fetal Brain Damage in Early Abortions of Ovine Toxoplasmosis.

Vet Pathol 2020 Jul 14;57(4):535-544. Epub 2020 May 14.

Instituto de Ganadería de Montaña (CSIC-Universidad de León), Grulleros, León, Spain.

There is an unacknowledged clinical presentation of ovine toxoplasmosis characterized by early abortions and lesions of fetal leukoencephalomalacia. To investigate the pathogenesis of this condition, the extent and distribution of leukomalacia and the variations in the cell populations associated with it were characterized in 32 fetal brains from 2 previously published experimental studies of infection in pregnant sheep. Immunohistochemical labeling of βAPP allowed for the detection of leukomalacia in 100/110 (91%) studied samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300985820921539DOI Listing

Alteration in brain connectivity in patients with Dravet syndrome after vagus nerve stimulation (VNS): exploration of its effectiveness using graph theory analysis with electroencephalography.

J Neural Eng 2020 Jun 22;17(3):036014. Epub 2020 Jun 22.

RFIC Center, Kwangwoon University, 447-1 Wolgye-Dong, Nowon-Ku, Seoul 139-701, Republic of Korea. These authors contributed equally to this work.

Objective: Vagus nerve stimulation (VNS) is a nonpharmacologic therapeutic option for patients who have pharmaco-resistant Dravet syndrome (DS). Plentiful efforts have been made for delivering VNS to DS patients, but its effectiveness still requires further verification. We investigated the effectiveness of the VNS treatment of DS patients using brain connectivity analysis with electroencephalography (EEG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/ab914fDOI Listing

Orbital Compartment Syndrome After Pterional Craniotomy for Removal of Meningioma of the Frontal Lobe Without Evidence of Orbital Mass or Ocular Compression: A Case Report and Literature Review.

World Neurosurg 2020 Apr 25. Epub 2020 Apr 25.

Clinical Teaching Fellow, Division of Neurosurgery, Department of Surgery, Uniformed University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814.

A 76-year-old male whose brain MRI demonstrated an anterior right frontal broad dural based homogenously enhancing mass measuring 6.0x3.1x6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2020.04.094DOI Listing

Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause.

Acta Neurol Belg 2020 Apr 24. Epub 2020 Apr 24.

Department of Neuroscience, Aziz Sancar Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey.

Anti-neuronal antibodies that are related with autoimmune encephalitis syndromes may also be found in children with new onset seizures or chronic epilepsy. To unravel the significance of autoimmune astrocytopathy in epilepsy, we investigated serum antibody to glial fibrillary acidic protein (GFAP), another autoantigen described in autoimmune encephalitis with seizures, in 38 children with focal seizures of undetermined cause. GFAP antibody was screened with cell based assay and indirect immunohistochemistry and was found in two boys with normal brain MRI and unrevealing medical history prior to seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-020-01361-yDOI Listing

Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

J Med Virol 2020 Jul;92(7):699-702

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.25915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264598PMC

Role of diffusion tensor imaging in analyzing the neural connectivity of the parieto-insular vestibular cortex in pusher syndrome: As case report.

Medicine (Baltimore) 2020 Apr;99(16):e19835

Department of Physical Therapy, College of Health Sciences, Dankook University.

Rationale: Pusher syndrome is a disorder of postural control. It is associated with unilateral lesions on central vestibular system. In the current study, we attempted to identify and investigate neural connectivity of the parieto-insular vestibular cortex in a patient with pusher syndrome, using diffusion tensor imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000019835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220494PMC

Praxis-induced reflex seizures in two Japanese cases with ring chromosome 20 syndrome.

Epileptic Disord 2020 Apr;22(2):214-218

Department of Paediatrics, Jichi Medical University, Shimotsuke, Japan.

Ring chromosome 20 syndrome is an epileptic and neurodevelopmental encephalopathy that occurs in children, characterised by a triad of refractory frontal lobe seizures, recurrent non-convulsive status epilepticus and frontal lobe-dominant paroxysmal discharges. However, details of other clinical features associated with ring chromosome 20 syndrome remain unknown. Here, we report two patients with ring chromosome 20 syndrome who had praxis-induced reflex seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2020.1146DOI Listing

Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.

Brain Dev 2020 Jun 1;42(6):473-476. Epub 2020 Apr 1.

Department of Pediatrics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Background: Ring chromosome 20 syndrome is a rare chromosomal disorder characterized by refractory seizure, mental retardation, and behavioral problems. Although there are reports of the effective treatment of patients with antiepileptic drugs (AEDs), no study has reported the effects of lacosamide(LCM) in children with this syndrome. We report a 7-year-old boy with this syndrome whose refractory and behavioral abnormalities have been remarkably improved by treatment with LCM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2020.03.003DOI Listing

Acute post-stroke restless legs syndrome: the body of caudate nucleus considerations.

Sleep Med 2020 Jun 19;70:66-70. Epub 2019 Dec 19.

Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, PR China. Electronic address:

Objectives: To investigate the relationship between the lesion location and post-stroke restless legs syndrome (RLS).

Methods: A total of 376 patients with acute cerebral infarction were recruited from Tangshan Gongren Hospital, Department of Neurology between May 2016 and May 2017, all of whom were evaluated for RLS. Established RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG) in 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2019.11.1253DOI Listing

Multiphasic acute disseminated encephalomyelitis and differential with early onset multiple sclerosis.

Intractable Rare Dis Res 2020 Feb;9(1):61-63

Neurophysiology Department, Clínica das Américas, Curitiba, Brasil.

Multiple sclerosis is considered the most frequent demyelinating disorder of the Central Nervous System (CNS) among young adults, yet is very rare before 10 years old. Acute disseminated encephalomyelitis is a monophasic, polysymptomatic disorder that involves the CNS white matter with demyelinating lesions, which usually occurs after systemic viral infections. These two demyelinating diseases can present initially as an acute focal neurological syndrome and they can be difficult to distinguish. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5582/irdr.2020.01009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062603PMC
February 2020

Pathological laughing and psychotic disorder: the medical evaluation of the Joker.

Acta Neurol Belg 2020 Mar 18. Epub 2020 Mar 18.

Department of Anesthesiology, Universitary Hospital Charles Nicolles, 37 Boulevard Gambetta, 76000, Rouen, France.

In the psychological thriller film Joker, released in 2019 and starring Joaquin Phoenix in the first role, another possible origin story for this iconic character is reported. Above all, it brings us medical elements for the understanding of the development of this complex character. Contrary to other interpretations, we discover a lonely, timid and uncharismatic man (Arthur Fleck). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-020-01332-3DOI Listing

Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA currents, but are not neurotoxic to the developing rat brain.

Br J Anaesth 2020 05 6;124(5):603-613. Epub 2020 Mar 6.

Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Background: The most currently used general anaesthetics are potent potentiators of γ-aminobutyric acid A (GABA) receptors and are invariably neurotoxic during the early stages of brain development in preclinical animal models. As causality between GABA potentiation and anaesthetic-induced developmental neurotoxicity has not been established, the question remains whether GABAergic activity is crucial for promoting/enhancing neurotoxicity. Using the neurosteroid analogue, (3α,5α)-3-hydroxy-13,24-cyclo-18,21-dinorchol-22-en-24-ol (CDNC24), which potentiates recombinant GABA receptors, we examined whether this potentiation is the driving force in inducing neurotoxicity during development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222221PMC

Body mass index, residual psychotic symptoms, and inflammation associated with brain volume reduction in older patients with schizophrenia.

Int J Geriatr Psychiatry 2020 Jul 12;35(7):728-736. Epub 2020 Mar 12.

Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.

Obesity, aging, and pathophysiology of schizophrenia (SCZ) may collectively contribute to the gray matter loss in brain regions of SCZ. We attempted to examine the association between volumes of specific brain regions, body mass index (BMI), inflammatory markers, and clinical features in older SCZ patients.

Method: Clinically stable outpatients with schizophrenia (DSM-IV) aged ≥50 years were recruited to undergo whole-brain magnetic resonance imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gps.5291DOI Listing

Atypical presentation of cerebellar posterior reversible encephalopathy syndrome in a patient with HIV.

Clin Case Rep 2020 Feb 11;8(2):262-264. Epub 2020 Jan 11.

Department of Neurology Adventist Health White Memorial Los Angeles California.

This case report is meant to widen the scope of lesion locations in posterior reversible encephalopathy syndrome (PRES) to include the brainstem, frontal lobe, and basal ganglia in order to increase the diagnosis and treatment of PRES. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044385PMC
February 2020

Sleep Disorders in Four Patients With Myotonic Dystrophy Type 1.

Front Neurol 2020 14;11:12. Epub 2020 Feb 14.

Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Sleep disturbances such as excessive daytime sleepiness, central and obstructive sleep apneas, restless legs syndrome, and rapid eye movement sleep dysregulation are prominent in patients with myotonic dystrophy type 1 (DM1). Mild intellectual deficits presented in many patients with DM1. In addition, psychosocial issues caused by neuropsychiatric symptoms are a clinical problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2020.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034466PMC
February 2020

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

Res Dev Disabil 2020 Feb 24;99:103575. Epub 2020 Feb 24.

National Institute of Mental Health, Bethesda, MD, United States.

Background: Down syndrome is associated with poor sleep but little is known about its neural correlates.

Aims: The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ridd.2020.103575DOI Listing
February 2020

Amnestic and non-amnestic symptoms of dementia: An international study of Alzheimer's disease in people with Down's syndrome.

Int J Geriatr Psychiatry 2020 Jun 15;35(6):650-661. Epub 2020 Mar 15.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

The presence of age-related neuropathology characteristic of Alzheimer's disease (AD) in people with Down syndrome (DS) is well-established. However, the early symptoms of dementia may be atypical and appear related to dysfunction of prefrontal circuitry.

Objective: To characterize the initial informant reported age-related neuropsychiatric symptoms of dementia in people with DS, and their relationship to AD and frontal lobe function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gps.5283DOI Listing

Posterior reversible encephalopathy syndrome induced by intracranial hypotension in a postpartum patient.

Int J Neurosci 2020 Mar 2:1-5. Epub 2020 Mar 2.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

A number of hormonal, physiologic, immunologic, and hemodynamic changes can cause a series of central nervous system-related problems in pregnant and postpartum women. Posterior reversible encephalopathy syndrome (PRES) is commonly seen in these conditions. However, PRES during pregnancy and the postpartum period are not always due to pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00207454.2020.1733555DOI Listing

Progressive supranuclear palsy presenting with hyperkinetic movement disorder and hemiplegic dystonia: a case report.

Int J Neurosci 2020 Mar 5:1-4. Epub 2020 Mar 5.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

Progressive supranuclear palsy (PSP) is a progressive neurodegenerative brain disease which has been rarely described in association with hyperkinetic symptoms. Here, we report a case of PSP that was presented with hyperkinetic movement disorder, hemiplegic dystonia, and other clinical features that overlap with behavioral variant frontotemporal dementia (bvFTD) and corticobasal syndrome (CBS). A 63-year-old female presented to our hospital with a history of frontal lobe symptoms, impaired cognition, hyperkinetic movement disorders, dystonia, and frequent falls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00207454.2020.1732965DOI Listing

Bilateral basal ganglia infarcts presenting as rapid onset cognitive and behavioral disturbance.

Neurocase 2020 04 11;26(2):115-119. Epub 2020 Feb 11.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.

We describe a rare case of a patient with rapid onset, prominent cognitive and behavioral changes who presented to our rapidly progressive dementia program with symptoms ultimately attributed to bilateral basal ganglia infarcts involving the caudate heads. We review the longitudinal clinical presentation and neuropsychological testing for this patient, and discuss the implicated basal ganglia and frontal lobe neuroanatomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13554794.2020.1728341DOI Listing

A Case of Delayed Diagnosis of Moyamoya Disease After Recurrent Strokes.

Cureus 2019 Dec 22;11(12):e6446. Epub 2019 Dec 22.

Critical Care Medicine, Aventura Hospital and Medical Center, Aventura, USA.

We present a case of a 58-year-old man with delayed diagnosed moyamoya disease who underwent encephaloduroarteriosynangiosis (EDAS) procedure. This patient with a history of three strokes presented to our facility with new left facial droop. Neurological examination revealed left facial droop and hemiparesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.6446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975246PMC
December 2019

Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.

CNS Drugs 2020 Feb;34(2):147-161

Scottish Epilepsy Initiative, Glasgow, UK.

Common genetic generalised epilepsy syndromes encountered by clinicians include childhood and juvenile absence epilepsies, juvenile myoclonic epilepsy and generalised tonic-clonic seizures on awakening. Treatment of these syndromes involves largely the use of broad-spectrum antiseizure drugs. Those effective for the generalised epilepsies include sodium valproate, phenobarbital, ethosuximide, clobazam, clonazepam, lamotrigine, levetiracetam, topiramate, zonisamide and, more recently, perampanel and brivaracetam. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40263-020-00698-5DOI Listing
February 2020

Posterior reversible encephalopathy syndrome with ischemic infarction complicated with intrauterine fetal death: A case report.

Medicine (Baltimore) 2020 Jan;99(4):e18877

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Rationale: Posterior reversible encephalopathy syndrome (PRES), a rare neurologic disorder, manifests as headache, altered mental status, seizures, visual disturbances, and other focal neurologic signs with typically reversible clinical symptoms and image changes. Although the underlying mechanism remains unknown, a current theory indicates cerebral autoregulation failure as the primary cause. We report a case of PRES with stroke in an adult with intrauterine fetal death (IUFD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004726PMC
January 2020

Temporal and anatomical distribution of F-flutemetamol uptake in canine brain using positron emission tomography.

BMC Vet Res 2020 Jan 17;16(1):17. Epub 2020 Jan 17.

Veterinary Teaching Hospital, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 28644, South Korea.

Background: Positron emission tomography (PET) is increasingly being used as an imaging modality for clinical and research applications in veterinary medicine. Amyloid PET has become a useful tool for diagnosing Alzheimer's disease (AD) in humans, by accurately identifying amyloid-beta (Aβ) plaques. Cognitive dysfunction syndrome in dogs shows cognitive and pathophysiologic characteristics similar to AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12917-020-2240-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969467PMC
January 2020

Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis.

Mol Psychiatry 2020 Jan 10. Epub 2020 Jan 10.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

The 22q11.2 deletion syndrome (22q11.2DS) is a neurodevelopmental disorder associated with a number of volumetric brain abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41380-019-0638-3DOI Listing
January 2020

Reversibility of impaired brain structures after transsphenoidal surgery in Cushing's disease: a longitudinal study based on an artificial intelligence-assisted tool.

J Neurosurg 2020 Jan 3:1-10. Epub 2020 Jan 3.

Departments of1Radiology and.

Objective: Cushing's disease (CD) involves brain impairments caused by excessive cortisol. Whether these impairments are reversible in remitted CD after surgery has long been controversial due to a lack of high-quality longitudinal studies. In this study the authors aimed to assess the reversibility of whole-brain changes in remitted CD after transsphenoidal surgery (TSS), and its correlations with clinical and hormonal parameters, in the largest longitudinal study cohort to date for CD patient brain analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2019.10.JNS191400DOI Listing
January 2020

Emotional disorder syndrome after cosmetic facial injection.

J Cosmet Dermatol 2020 Jan 2. Epub 2020 Jan 2.

Department of Plastic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

There are a number of patients who develop severe anxiety or depression after receiving facial cosmetic injections. We presented a 32-year-old woman who developed frequent panic, tension headache, tachycardia, shortness of breath, and sleep disorder for a year after the injection of hyaluronic acid on her forehead and glabella. Brain magnetic resonance imaging (MRI) showed multiple flaky and slightly longer T1, slightly longer T2 signals on the anterior frontal white matter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13283DOI Listing
January 2020

Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome-A Case-Control Study.

J Clin Endocrinol Metab 2020 May;105(5)

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Background: Young patients with Cushing Syndrome (CS) may develop cognitive and behavioral alterations during disease course.

Methods: To investigate the effects of CS on the brain, we analyzed consecutive MRI scans of patients with (n = 29) versus without CS (n = 8). Multiple brain compartments were processed for total and gray/white matter (GM/WM) volumes and intensities, and cortical volume, thickness, and surface area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgz303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089850PMC

Epilepsy with migrating focal seizures: KCNT1 mutation hotspots and phenotype variability.

Neurol Genet 2019 Dec 25;5(6):e363. Epub 2019 Oct 25.

Service de Génétique (G.B., J.-P.B., S.G.-L.), Groupe Hospitalier Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1163 (G.B., N.B-.B., R.N.), Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France; Service de Neurologie Pédiatrique (N.C., N.B-.B., A.K., R.N.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Centre de Référence des Epilepsies Rares (N.C., A.K., R.N.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1129 (N.N., A.K., R.N.), Paris, France; Service de Neurophysiologie Clinique et Pédiatrie (M.K.), INSERM U1099, Hôpital Universitaire de Rennes, Université de Rennes, France; Service de Neurophysiologie Clinique (M.E., A.K.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Génétique Clinique (V.C.), Hôpital Femme Mère Enfant, Metz-Thionville, France; Pediatric Neurology Research Group (A.M.), Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain; Service de Génétique Clinique (L.L.), Hôpital d'Enfants, CHU de Nancy, Vandoeuvre-Lès-Nancy, France; Service de Pédiatrie (F.D.), CHU de Grenoble, France; Service de Neurologie Pédiatrique (D.D., T.B.V.), Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Neurologie Pédiatrique (N.V., M.M.), APHM, Hôpital d'Enfants de La Timone, Marseille, France; Service de Neurologie Pédiatrique (M-.A.B., M.M.), Centre Hospitalier Universitaire de Tours, Tours, France; Département de Génétique (C.N., M.M.), Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Radiologie Pédiatrique (N.B., M.M.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Aix-Marseille (M.M.), INSERM, MMG, UMR-S 1251, Faculté de Médecine, Marseille, France; and Unité de Neurologie Pédiatrique (S.A.), Hôpital Rober Debré, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To report new sporadic cases and 1 family with epilepsy of infancy with migrating focal seizures (EIMFSs) due to KCNT1 gain-of-function and to assess therapies' efficacy including quinidine.

Methods: We reviewed the clinical, EEG, and molecular data of 17 new patients with EIMFS and mutations, in collaboration with the network of the French reference center for rare epilepsies.

Results: The mean seizure onset age was 1 month (range: 1 hour to 4 months), and all children had focal motor seizures with autonomic signs and migrating ictal pattern on EEG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878841PMC
December 2019

Delayed neuropsychiatric syndrome of acute carbon monoxide poisoning from oak burning gas cured by therapy combined with transplantation of human umbilical cord blood stem cell, injection of nicholine, and intranasal inhalation of insulin.

Neurocase 2020 02 22;26(1):64-68. Epub 2019 Dec 22.

Department for Stem Cell Research, Basic Medical Faculty, Pyongyang Medical College, Kim Il Sung University.

A 55-year-old woman was admitted for the delayed neuropsychiatric syndrome of carbon monoxide (CO) poisoning (NSCs) from oak burning. Brain MRI showed diffuse high-intensity lesions on T2-weighted images of the left frontal and the occipital lobe. : The patient received transplantation of umbilical cord blood (UCB) stem cells, combined with injection of nicholine, intranasal inhalation of insulin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13554794.2019.1706748DOI Listing
February 2020

The behavioral dyscontrol scale in the differential diagnosis of behavioral variant of frontotemporal dementia and Alzheimer disease.

Clin Neuropsychol 2019 Dec 16:1-10. Epub 2019 Dec 16.

Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.

The Behavioral Dyscontrol Scale (BDS) is a brief measure of frontal systems that is adopted from Luria's syndrome analysis approach. The aim of this study was to evaluate the diagnostic utility of the BDS as an objective measure of self-regulation in behavioral variant of frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Two patient groups matched in education and dementia severity (n = 21 bvFTD and 21 AD) recruited from a memory clinic and a matched normal control (NC) group (n = 21) were administered a battery of neuropsychological tests including the BDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13854046.2019.1701709DOI Listing
December 2019

Plasma luteinizing hormone level affects the brain activity of patients with polycystic ovary syndrome.

Psychoneuroendocrinology 2020 02 28;112:104535. Epub 2019 Nov 28.

MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, PR China. Electronic address:

Objective: Cognitive function has been reported to be impaired in women with polycystic ovary syndrome (PCOS). This study aimed to investigate the effect of PCOS on brain activity and explore the relationship between brain activity and sex hormone levels in women with PCOS (WPCOS).

Methods: Twenty-one women aged 18-45 years old with new-diagnosed PCOS were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psyneuen.2019.104535DOI Listing
February 2020

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice.

Life Sci 2020 Jan 13;241:117163. Epub 2019 Dec 13.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 40, NL 6229ER Maastricht, the Netherlands; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, 119991 Moscow, Russia; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080 Würzburg, Germany. Electronic address:

Aims: The high sugar and lipid content of the Western diet (WD) is associated with metabolic dysfunction, non-alcoholic steatohepatitis, and it is an established risk factor for neuropsychiatric disorders. Our previous studies reported negative effects of the WD on rodent emotionality, impulsivity, and sociability in adulthood. Here, we investigated the effect of the WD on motor coordination, novelty recognition, and affective behavior in mice as well as molecular and cellular endpoints in brain and peripheral tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.117163DOI Listing
January 2020

F-fluorodexyglucose Position Emission Tomography identifies altered brain metabolism in patients with Cri du Chat syndrome.

J Nucl Med 2019 Dec 13. Epub 2019 Dec 13.

Paediatric Unit, Castelli Hospital, Italy.

Cri-Du-Chat Syndrome (CdCs) is a rare genetic disease caused by a deletion in the short arm of chromosome 5 (5p) with a variable clinical spectrum. To date no study in literature has ever investigated the alterations of brain glucose metabolism in these subjects by means of [F]fluoro-2-deoxy-d-glucose Positron Emission Tomography/Computed Tomography (F-FDG PET/CT). The aims of this study were to detect difference in brain FDG metabolism in patients affected by CdCs with different clinical presentations and identify possible "brain metabolic phenotypes" of this syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.119.236893DOI Listing
December 2019

Sleep-related hypermotor epilepsy (SHE): Contribution of known genes in 103 patients.

Seizure 2020 Jan 23;74:60-64. Epub 2019 Nov 23.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Purpose: Genetics of Sleep-related Hypermotor Epilepsy (SHE) includes mutations in several genes that cumulatively account for 30 % of families. This approximate estimate comes from different case-series, each focused on the screening of a single gene. We systematically investigated a large cohort of SHE patients to estimate the frequency of pathogenic variants in the main genes thus far implicated in this epilepsy syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.11.009DOI Listing
January 2020