4,567 results match your criteria Frontal Lobe Epilepsy


Deep Cerebellar Nuclei Functional Connectivity with Cerebral Cortex in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizures: a Resting-State fMRI Study.

Cerebellum 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.

We aimed to explore the altered functional connectivity patterns within cerebello-cerebral circuits in temporal lobe epilepsy (TLE) patients with and without focal to bilateral tonic-clonic seizures (FBTCS). Forty-two patients with unilateral TLE (21 with and 21 without FBTCS) and 22 healthy controls were recruited. We chose deep cerebellar nuclei as seed regions, calculated static and dynamic functional connectivity (sFC and dFC) in the patients with and without FBTCS and healthy controls, and compared sFC and dFC among the three groups. Read More

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Successful stereoelectroencephalography-guided radiofrequency thermocoagulation in the treatment of a patient with mesial frontal region-originated mirthful gelastic seizure.

Clin Neurol Neurosurg 2021 May 27;207:106713. Epub 2021 May 27.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China; Beijing Institute for Brain Disorders, Capital Medical University, No. 10, West Tou Tiao, Outer You'an Men, Fengtai District, Beijing 100069, China. Electronic address:

Gelastic seizures (GS), characterized by automatic bouts of unnatural stereotyped laughter and commonly recognized as the hallmark of hypothalamic hamartoma, is rarely associated with cortical epileptogenic focus. Whether there is a dissociation of the motor program of laughter and the experience of mirth and the symptomatogenic zone for ictal laughter with or without mirth are still unclear. We report a patient with drug-resistant mirthful GS who receive a comprehensive investigation of stereoelectroencephalography recording and electrocortical stimulation. Read More

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Neural networks underlying hyperkinetic seizures: A quantitative PET and SEEG study.

Epilepsy Behav 2021 Jun 18;122:108130. Epub 2021 Jun 18.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neurostimulation, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address:

Objective: Hyperkinetic seizures (HKS) are characterized by complex movements that commonly occur during seizures arising from diverse cortical structures. A common semiology network may exist and analyzing the anatomo-electrical mechanisms would facilitate presurgical evaluation. Here, quantitative positron emission tomography (PET) and stereoelectroencephalography (SEEG) analysis was used to explore the underlying mechanism of HKS. Read More

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Epilepsy & gambling: Risk factors for problem gambling behaviors in people with epilepsy.

Epilepsy Behav 2021 Jun 17;122:108082. Epub 2021 Jun 17.

University College Hospital, London, United Kingdom; Department of Clinical and Experimental Epilepsy, UCL, Queen Square, Institute of Neurology, London, United Kingdom. Electronic address:

Objective: Problem gambling results from the complex interaction of neurological factors with psychological, demographic, and socioeconomical influences. The vulnerabilities of people with epilepsy to many of these influences may increase their susceptibility to developing problematic gambling behaviors. The aim of this study was to establish the frequency of gambling participation and the clinical correlates of problem gambling behaviors in people with epilepsy. Read More

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Whole-brain functional correlates of memory formation in mesial temporal lobe epilepsy.

Neuroimage Clin 2021 Jun 10;31:102723. Epub 2021 Jun 10.

Bielefeld University, Department of Psychology, Universitätsstraße 25, Bielefeld 33615, Germany; Center for Cognitive Interaction Technology (CITEC), University of Bielefeld, Inspiration 1, Bielefeld 33619, Germany.

The mesial temporal lobe is a key region for episodic memory. Accordingly, memory impairment is frequent in patients with mesial temporal lobe epilepsy. However, the functional relevance of potentially epilepsy-induced reorganisation for memory formation is still not entirely clear. Read More

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Headaches provoked by cortical stimulation: Their localizing value in focal epileptic seizures.

Epilepsy Behav 2021 Jun 15;122:108125. Epub 2021 Jun 15.

Lyon Neuroscience Research Center (CRNL), INSERM U1028, CNRS UMR5292, Lyon, France; Department of Neurology Neurological Hospital, Hospices Civils de Lyon and University of Lyon, France. Electronic address:

Objective: Electrical stimulations performed in awake patients identified dura mater, venous sinuses, and arteries as pain-sensitive intracranial structures. However, cephalic pain has been only occasionally reported in patients with epilepsy undergoing stereo-electroencephalography (SEEG) stimulations.

Methods: The aim of our study was to investigate whether headache can be triggered by SEEG stimulations and might be related to specific cortical areas. Read More

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Impact of mesial temporal lobe resection on brain structure in medically refractory epilepsy.

World Neurosurg 2021 Jun 15. Epub 2021 Jun 15.

Division of Neurosurgery, Toronto Western Hospital, University of Toronto. Electronic address:

Objective: Surgical resection can decrease seizure frequency in medically intractable temporal lobe epilepsy. The functional and structural consequences of this intervention on brain circuitry are poorly understood, however. We investigated structural changes that occur in brain circuits following mesial temporal lobe resection for refractory epilepsy. Read More

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Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery.

Neuroimage Clin 2021 Jun 2;31:102714. Epub 2021 Jun 2.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objective: To explore the structural and functional reorganization of contralateral hippocampus in patients with unilateral mesial temporal lobe epilepsy (mTLE) who achieved seizure-freedom after anterior temporal lobectomy (ATL).

Methods: We obtained high-resolution structural MRI and resting-state functional MRI data in 28 unilateral mTLE patients and 29 healthy controls. Patients were scanned before and three and 24 months after surgery while controls were scanned only once. Read More

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Two cases of DYNC1H1 mutations with intractable epilepsy.

Brain Dev 2021 Jun 3. Epub 2021 Jun 3.

Department of Pediatrics, Jichi Medical University, Tochigi, Japan. Electronic address:

Background: The DYNC1H1 gene encodes the heavy chain of cytoplasmic dynein 1, a core structure of the cytoplasmic dynein complex. Dominant DYNC1H1 mutations are implicated in Charcot-Marie-Tooth disease, axonal, type 20, spinal muscular atrophy, lower extremity-predominant 1, and autosomal dominant mental retardation 13 with neuronal migration defects. We report two patients with DYNC1H1 mutations who had intractable epilepsy and intellectual disability (ID), one with and one without pachygyria. Read More

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Experiences of emotional and psychosocial functioning after frontal lobe resection for epilepsy.

Epilepsy Behav 2021 Jun 1;121(Pt A):108077. Epub 2021 Jun 1.

Department of Neurology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden; Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Göteborg, Sweden. Electronic address:

Purpose: Frontal lobe resection (FLR) is the second most common epilepsy surgery procedure in adults. Few studies address neuropsychological consequences after FLR. The aim of this study was to explore patients' and relatives' experiences of cognitive, emotional and social cognitive functioning after frontal lobe epilepsy surgery. Read More

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A unique case of progressive hemifacial microsomia or Parry-Romberg syndrome associated with limb and brain anomalies with normal neurological findings: A review of the literature.

Eur J Med Genet 2021 May 31:104234. Epub 2021 May 31.

Division of Genetics and Metabolism, Department of Pediatrics, University of California, Irvine School of Medicine, Orange, CA. Electronic address:

In this report, we describe an unusual case of progressive hemifacial atrophy or Parry-Romberg syndrome in a 10-year-old girl with progressive hemifacial microsomia and limb anomalies who had brain magnetic resonance imaging (MRI) findings of white matter hyper-intensities. Patients typically present with neurological manifestations such as epilepsy, facial pain, and migraines and ophthalmological symptoms in conjunction with white matter lesions. The patient demonstrated normal cognition and psychomotor development despite the presence of white matter lesions in her frontal lobe that is commonly associated with neurological symptoms. Read More

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Aberrant cerebral intrinsic activity and cerebro-cerebellar functional connectivity in right temporal lobe epilepsy: a resting-state functional MRI study.

Neuroreport 2021 Jun 1. Epub 2021 Jun 1.

Department of Neurology, the People's Hospital of Guangxi Zhuang Autonomous Region Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Objective: Numerous neuroimaging studies have demonstrated that functional brain aberrations are associated with cognitive impairments in temporal lobe epilepsy (TLE). Here, we aimed to investigate the neural substrates of attention deficits by combining assessment of regional intrinsic brain activities with large-scale functional connectivity in patients with right TLE (rTLE).

Methods: Thirty-five patients with rTLE and 33 matched healthy controls were recruited. Read More

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Alterations in neural oscillations related to working memory deficit in temporal lobe epilepsy.

Epilepsy Behav 2021 May 27;121(Pt A):108063. Epub 2021 May 27.

General Medicine Department, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Neurological Institute, Tianjin 300052, China. Electronic address:

Objective: Working memory (WM) is critical for higher level cognition, but the underlying neural mechanisms are not fully understood. Impaired WM affects routine daily activities and is observed in patients with temporal lobe epilepsy (TLE). This study investigated neural oscillations associated with different WM phases, to determine the specific neural activity linked with the phases of WM impairment. Read More

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Mirror writing in a patient with frontal lobe epilepsy.

Clin Case Rep 2021 May 15;9(5):e04239. Epub 2021 May 15.

A.N. Murzaliev Department of Neurology and Clinical Genetics I.K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan.

During the postictal period, the left cerebral hemisphere was affected by the seizures, and consecutive epileptiform discharges and disinhibition of the right cerebral hemisphere could have occurred, which may explain the observed behavior. Read More

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Novelty processing depends on medial temporal lobe structures.

Neurobiol Learn Mem 2021 May 18;183:107464. Epub 2021 May 18.

Department of Education, VU University, Amsterdam, the Netherlands.

Objectives: The goal of the present study was to identify the role of the medial temporal lobe (MTL) in the detection and later processing of novelty.

Methods: Twenty-one epilepsy patients with unilateral MTL resection (10 left-sided; 11 right-sided) and 26 matched healthy controls performed an adapted visual novelty oddball task. In this task two streams of stimuli were presented on the left and right of fixation while the patients' electroencephalogram was measured. Read More

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How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism.

Hum Brain Mapp 2021 May 18. Epub 2021 May 18.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Interactions between interictal epileptiform discharges (IEDs) and distant cortical regions subserve potential effects on cognition of patients with focal epilepsy. We hypothesize that "healthy" brain areas at a distance from the epileptic focus may respond to the interference of IEDs by generating inhibitory alpha and beta oscillations. We predict that more prominent alpha-beta oscillations can be found in patients with less impaired neurocognitive profile. Read More

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Divergent Anatomical Correlates and Functional Network Connectivity Patterns in Temporal Lobe Epilepsy with and Without Depression.

Brain Topogr 2021 07 10;34(4):525-536. Epub 2021 May 10.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Epilepsy and depression were proposed to facilitate each other reciprocally through common neurobiological anomalies, especially the prefrontal-limbic-subcortical abnormalities. Yet neuroimaging patterns of higher-order cognitive networks and neuroanatomical correlates were rarely compared in temporal lobe epilepsy patients with (TLE-D) and without depression (TLE-N). We collected T1-weighted structural and resting-state functional MRI data from 20 TLE-D, 31 TLE-N and 20 healthy controls (HCs) and performed analyses including hippocampal volume (HCV), cortical thickness, gray matter volume (GMV) and whole-brain functional network connectivity (FNC) across three groups. Read More

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Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.

J Neuroimaging 2021 May 6. Epub 2021 May 6.

Epilepsy Unit, Department of Neurology, Hospital Universitari de Bellvitge, Barcelona, Spain.

Background And Purpose: Glutamic acid decarboxylase antibodies (GAD-Ab) are sometimes associated with chronic drug-resistant focal epilepsy. Clinically, it may manifest as mesial temporal lobe epilepsy (mTLE), with GAD-Ab patients difficult to distinguish. Therefore, the aim of this study is to compare brain metabolism of patients with mTLE and high serum titers of GAD-Ab (>2000 UI/ml) to those with mTLE and hippocampal sclerosis (HS) and confirmed GAD-ab negativity. Read More

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Temporal lobe epilepsy alters neural responses to human and avatar facial expressions in the face perception network.

Brain Behav 2021 Jun 5;11(6):e02140. Epub 2021 May 5.

Swiss Epilepsy Center, Zurich, Switzerland.

Background And Objective: Although avatars are now widely used in advertisement, entertainment, and business today, no study has investigated whether brain lesions in neurological patients interfere with brain activation in response to dynamic avatar facial expressions. The aim of our event-related fMRI study was to compare brain activation differences in people with epilepsy and controls during the processing of fearful and neutral dynamic expressions displayed by human or avatar faces.

Methods: Using functional magnetic resonance imaging (fMRI), we examined brain responses to dynamic facial expressions of trained actors and their avatar look-alikes in 16 people with temporal lobe epilepsy (TLE) and 26 controls. Read More

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Neuroendocrine changes in the hypothalamic-neurohypophysial system in the Wistar audiogenic rat (WAR) strain submitted to audiogenic kindling.

J Neuroendocrinol 2021 May 4:e12975. Epub 2021 May 4.

Laboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.

The Wistar audiogenic rat (WAR) strain is used as an animal model of epilepsy, which when submitted to acute acoustic stimulus presents tonic-clonic seizures, mainly dependent on brainstem (mesencephalic) structures. However, when WARs are exposed to chronic acoustic stimuli (audiogenic kindling-AK), they usually present tonic-clonic seizures, followed by limbic seizures, after recruitment of forebrain structures such as the cortex, hippocampus and amygdala. Although some studies have reported that hypothalamic-hypophysis function is also altered in WAR through modulating vasopressin (AVP) and oxytocin (OXT) secretion, the role of these neuropeptides in epilepsy still is controversial. Read More

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Agitation and Dementia: Prevention and Treatment Strategies in Acute and Chronic Conditions.

Front Neurol 2021 16;12:644317. Epub 2021 Apr 16.

Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.

Agitation is a behavioral syndrome characterized by increased, often undirected, motor activity, restlessness, aggressiveness, and emotional distress. According to several observations, agitation prevalence ranges from 30 to 50% in Alzheimer's disease, 30% in dementia with Lewy bodies, 40% in frontotemporal dementia, and 40% in vascular dementia (VaD). With an overall prevalence of about 30%, agitation is the third most common neuropsychiatric symptoms (NPS) in dementia, after apathy and depression, and it is even more frequent (80%) in residents of nursing homes. Read More

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Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE): a widespread disease with an apparently focal epilepsy.

Epileptic Disord 2021 Apr;23(2):407-411

Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.

Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized, highly epileptogenic, distinct histopathological entity in drug-resistant epilepsy that primarily involves the frontal lobes. Surgical outcomes in MOGHE are variable. Although the diagnosis is based on histopathology, high-resolution MRI helps to differentiate MOGHE preoperatively from other forms of cortical malformations (i. Read More

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Intracranial EEG evidence of functional specialization for taxonomic and thematic relations.

Cortex 2021 07 9;140:40-50. Epub 2021 Apr 9.

Department of Psychology, University of Edinburgh, Edinburgh, UK.

The dual-hub account posits that the neural organization of semantic knowledge is segregated by the type of semantic relation with anterior temporal lobe (ATL) specializing for taxonomic relations and inferior parietal lobule (IPL) for thematic relations. This study critically examined this account by recording intracranial EEG from an array of depth electrodes within ATL, IPL, and two regions within the semantic control network, inferior frontal gyrus (IFG) and posterior middle temporal gyrus (pMTG), while 17 participants with refractory epilepsy completed a semantic relatedness judgment task. We observed a significant difference between relation types in ATL and IPL approximately 600-800 ms after trial presentation, and no significant differences in IFG or pMTG. Read More

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Chapeau de gendarme in a toddler points to focal epilepsy originating from the subcentral gyrus.

Epileptic Disord 2021 Apr;23(2):412-418

Department of Neuropediatrics, University Children's Hospital Zurich, Switzerland.

The chapeau de gendarme sign or ictal pouting has been associated with focal epilepsy of frontal origin. The identification and characterization of this semiologic feature derive mainly from adult epilepsy surgery series, whereas paediatric cases have rarely been reported. Here, we present a 14-month-old girl with a chapeau de gendarme sign with eyes closed as the sole initial manifestation of left frontal lobe epilepsy. Read More

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Rage and aggressive behaviour in frontal lobe epilepsy: description of a case and review of the mechanisms of aggressive behaviour in epilepsy and dementia.

Epileptic Disord 2021 Apr;23(2):419-425

Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

The study of dementia and epilepsy may provide particular insight into behavioural alterations. We describe a rare case of ictal aggressive behaviour in a patient with focal epilepsy associated with a non-dominant dorso-lateral prefrontal lesion. During focal seizures, our patient showed intense agitation and anger, for a long time misinterpreted as psychogenic attacks, which disappeared after epilepsy surgery. Read More

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Functional Connectivity in Dorsolateral Frontal Cortex: Intracranial Electroencephalogram Study.

Brain Connect 2021 Jun 1. Epub 2021 Jun 1.

Department of Neurology, Wilder Center for Epilepsy Research, University of Florida, Gainesville, Florida, USA.

Mechanisms underlying the variation in the appearance of electroencephalogram (EEG) over human head are not well characterized. We hypothesized that spatial variation of the EEG, being ultimately linked to variations in cortical neurobiology, was dependent on cortical connectivity patterns. Specifically, we explored the relationship of resting-state functional connectivity derived from intracranial EEG (iEEG) data in seven ( = 7) human epilepsy patients with the intrinsic dynamic variability of the local iEEG. Read More

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Cognitive Dysfunction in Juvenile Myoclonic Epilepsy (JME) - A Tertiary Care Center Study.

Ann Indian Acad Neurol 2021 Jan-Feb;24(1):40-50. Epub 2021 Feb 16.

Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research (GIPMER), New Delhi, India.

Background And Aim: Epilepsy often leads to cognitive impairment. Idiopathic generalized epilepsy as a group is considered to be benign in terms of its effects on cognition. Though, neuropsychological testing reveals subtle frontal impairment in patients with juvenile myoclonic epilepsy (JME). Read More

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February 2021

Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients.

Neurology 2021 05 28;96(21):e2639-e2652. Epub 2021 Apr 28.

From the Comprehensive Epilepsy Center (D.F.L., C.V., S.D., D.F., O.D.), Proteomics Laboratory (E.K., S.N., B.U.), Division of Advanced Research Technologies, and Department of Biochemistry and Molecular Pharmacology (B.U.), NYU School of Medicine; Department of Neurology (D.F.L., G.P., A.F., E.D., S.D., D.F., T.W., B.U., O.D.), Center for Cognitive Neurology (G.P., A.F., E.D., T.W.), Department of Pathology (T.W.), and Department of Psychiatry (T.W.), NYU Langone Health and School of Medicine, New York; Department of (Neuro)Pathology (J.D.M., J.J.A., E.A.v.V., E.A.), Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, the Netherlands; Alzheimer's and Prion Diseases Team (G.P.), Paris Brain Institute, CNRS, UMR 7225, INSERM 1127, Sorbonne University UM75, Paris, France; Brain & Mind Centre and School of Medical Sciences (E.D.), Faculty of Medicine and Health, University of Sydney, Australia; Biomedical Hosting LLC (M.A.), Arlington, MA; School of Biotechnology and Biomolecular Sciences (B.J.C., M.J.), University of New South Wales, Sydney, Australia; Amsterdam UMC (J.C.B., S.I.), Vrije Universiteit Amsterdam, Department of Neurosurgery, Amsterdam Neuroscience, De Boelelaan 1117; Swammerdam Institute for Life Sciences (E.A.v.V.), Center for Neuroscience, University of Amsterdam, the Netherlands; Department of Clinical and Experimental Epilepsy (B.D., C.S., M.T.), University College London Institute of Neurology, UK; and Stichting Epilepsie Instellingen Nederland (R.T., E.A.), Heemstede, the Netherlands

Objective: To identify the molecular signaling pathways underlying sudden unexpected death in epilepsy (SUDEP) and high-risk SUDEP compared to control patients with epilepsy.

Methods: For proteomics analyses, we evaluated the hippocampus and frontal cortex from microdissected postmortem brain tissue of 12 patients with SUDEP and 14 with non-SUDEP epilepsy. For transcriptomics analyses, we evaluated hippocampus and temporal cortex surgical brain tissue from patients with mesial temporal lobe epilepsy: 6 low-risk and 8 high-risk SUDEP as determined by a short (<50 seconds) or prolonged (≥50 seconds) postictal generalized EEG suppression (PGES) that may indicate severely depressed brain activity impairing respiration, arousal, and protective reflexes. Read More

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Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort.

Epilepsia 2021 Jun 22;62(6):1429-1441. Epub 2021 Apr 22.

Department of Neurology, University of Campinas, Campinas, São Paulo, Brazil.

Objective: We aimed to better characterize the magnetic resonance imaging (MRI) findings of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE), a rare clinicopathological entity associated with pharmacoresistance recently described in patients with frontal lobe epilepsy.

Methods: We studied 12 patients who underwent epilepsy surgery and whose surgical specimens showed histopathological findings of MOGHE, characterized by preserved cortical lamination, blurred gray-white matter interface due to increased number of oligodendrocytes, and heterotopic neurons in the white matter. The age at MRI evaluation ranged from 11 to 58 years, except for one 4. Read More

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Association of hypometabolic extension of F-FDG PET with diffusion tensor imaging indices in mesial temporal lobe epilepsy with hippocampal sclerosis.

Seizure 2021 May 18;88:130-137. Epub 2021 Apr 18.

Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.

Purpose: To assess the association between hypometabolic extension of F-fluorodeoxyglucose positron emission tomography and diffusion tensor imaging indices, including mean diffusivity (MD) and fractional anisotropy (FA), in hippocampal sclerosis (HS).

Methods: Thirty-six unilateral HS were retrospectively selected and stratified into two groups: broad and localized hypometabolic groups (hypometabolism beyond [n = 26] and within the temporal lobe [n = 10]). Forty-one pairs of gray matter (GM) regions of interest (ROIs) were segmented using FreeSurfer software. Read More

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