4,743 results match your criteria Frontal Lobe Epilepsy


Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth disease.

Ann Clin Transl Neurol 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Recessive mutations in SLC12A6 have been linked to hereditary motor sensory neuropathy with agenesis of the corpus callosum. Patients with early-onset peripheral neuropathy associated with SLC12A6 heterozygous variants were reported in 2016. Only five families and three variants have been reported to date, and the spectrum is unclear. Read More

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Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure.

Front Psychiatry 2022 2;13:888150. Epub 2022 Jun 2.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Purpose: Previous research has shown that subcortical brain regions are related to vigilance in temporal lobe epilepsy (TLE). However, it is unknown whether alterations in the function and structure of basal forebrain (BF) subregions are associated with vigilance impairment in distinct kinds of TLE. We aimed to investigate changes in the structure and function BF subregions in TLE patients with and without focal to bilateral tonic-clonic seizures (FBTCS) and associated clinical features. Read More

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Superficial and deep white matter diffusion abnormalities in focal epilepsies.

Epilepsia 2022 Jun 16. Epub 2022 Jun 16.

Department of Neurology, University of Campinas, São Paulo, Brazil.

Objective: This study was undertaken to evaluate superficial-white matter (WM) and deep-WM magnetic resonance imaging diffusion tensor imaging (DTI) metrics and identify distinctive patterns of microstructural abnormalities in focal epilepsies of diverse etiology, localization, and response to antiseizure medication (ASM).

Methods: We examined DTI data for 113 healthy controls and 113 patients with focal epilepsies: 51 patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) refractory to ASM, 27 with pharmacoresponsive TLE-HS, 15 with temporal lobe focal cortical dysplasia (FCD), and 20 with frontal lobe FCD. To assess WM microstructure, we used a multicontrast multiatlas parcellation of DTI. Read More

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The localization and lateralization of fear aura and its surgical prognostic value in patients with focal epilepsy.

Ann Clin Transl Neurol 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

Objective: Fear aura has traditionally been considered relevant to epileptic discharges from mesial temporal areas, and few studies have investigated its effect on surgical outcome in drug-resistant epilepsy. We aim to assess the localizing and lateralizing value as well as prognostic significance of fear aura in patients with focal epilepsy.

Methods: The occurrence of fear aura in relation to epileptogenic origin and its association with postoperative outcome were analyzed in 146 consecutive patients undergoing resective surgery for intractable epilepsy. Read More

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Altered Structural and Functional Patterns Within Executive Control Network Distinguish Frontal Glioma-Related Epilepsy.

Front Neurosci 2022 26;16:916771. Epub 2022 May 26.

Department of Neurosurgery, The Translational Research Institute for Neurological Disorders of Wannan Medical College, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College, Wuhu, China.

Background: The tumor invasion of the frontal lobe induces changes in the executive control network (ECN). It remains unclear whether epileptic seizures in frontal glioma patients exacerbate the structural and functional alterations within the ECN, and whether these changes can be used to identify glioma-related seizures at an early stage. This study aimed to investigate the altered structural and functional patterns of ECN in frontal gliomas without epilepsy (non-FGep) and frontal gliomas with epilepsy (FGep) and to evaluate whether the patterns can accurately distinguish glioma-related epilepsy. Read More

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A Study of Spontaneous Brain Activity on Resting-State Functional Magnetic Resonance Imaging in Adults with MRI-Negative Temporal Lobe Epilepsy.

Neuropsychiatr Dis Treat 2022 2;18:1107-1116. Epub 2022 Jun 2.

Department of Radiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, People's Republic of China.

Purpose: Patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE-N) represent an important subgroup of temporal lobe epilepsy (TLE). Here, we aimed to combine three voxel-based local brain area analysis methods of resting-state functional MRI (rs-fMRI), to examine the TLE-N patients' resting brain function based on neural synchronization and intensity of local brain areas.

Methods: The study included 47 patients with TLE, including 28 cases of drug-controlled TLE (cTLE-N) and 19 cases of drug-resistant TLE-N (rTLE-N), as well as 30 participants in the healthy control (HC) group. Read More

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Probabilistic landscape of seizure semiology localizing values.

Brain Commun 2022 19;4(3):fcac130. Epub 2022 May 19.

Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCL, London, UK.

Semiology describes the evolution of symptoms and signs during epileptic seizures and contributes to the evaluation of individuals with focal drug-resistant epilepsy for curative resection. Semiology varies in complexity from elementary sensorimotor seizures arising from primary cortex to complex behaviours and automatisms emerging from distributed cerebral networks. Detailed semiology interpreted by expert epileptologists may point towards the likely site of seizure onset, but this process is subjective. Read More

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Automated classification of cyclic alternating pattern sleep phases in healthy and sleep-disordered subjects using convolutional neural network.

Comput Biol Med 2022 Jul 10;146:105594. Epub 2022 May 10.

Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore, 599489, Singapore; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Department of Biomedical Engineering, School of Science and Technology, Singapore University of Social Sciences, 599491, Singapore. Electronic address:

Sleep contributes to more than a third of a person's life, making sleep monitoring essential for overall well-being. Cyclic alternating patterns (CAP) are crucial in monitoring sleep quality and associated illnesses such as insomnia, nocturnal frontal lobe epilepsy (NFLE), narcolepsy, etc. However, traditionally medical specialists practice manual division techniques of CAP phases which are sensitive to human weariness and inaccuracies. Read More

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Illustration of Altered Dopaminergic and GABAergic Systems in Early Parkinson's Disease.

Front Neurol 2022 17;13:880407. Epub 2022 May 17.

Department of Biofunctional Imaging, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: Changes in γ-aminobutyric acid (GABA) function are noted in patients with Parkinson's disease (PD) who have some non-motor impairments. However, dopamine-related GABA function and GABA-related cognitive changes are still unclear.

Methods: Thirteen drug-naive early-stage PD patients underwent a series of PET scans with [C]flumazenil(FMZ) and [C]CFT. Read More

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Correlations Between Structural Brain Abnormalities, Cognition and Electroclinical Characteristics in Patients With Juvenile Myoclonic Epilepsy.

Front Neurol 2022 16;13:883078. Epub 2022 May 16.

Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.

Objective: To explore the structural brain abnormality and its relationship with neuropsychological disorders and electroclinical characteristics in juvenile myoclonic epilepsy (JME) patients.

Methods: Sixty-seven patients diagnosed with JME and 56 healthy controls were enrolled. All subjects underwent MRI using T1-weighted 3D brain structural images with 1 mm thickness. Read More

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Brain mapping of emotional prosody in patients with drug-resistant temporal epilepsy: An indicator of plasticity.

Cortex 2022 May 27;153:97-109. Epub 2022 May 27.

Departamento de Psicología, Facultad de Ciencias Biomédicas, Universidad Austral, Pilar, Buenos Aires, Argentina; Unidad Ejecutora para el Estudio de las Neurociencias y Sistemas Complejos (ENyS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Introduction: Emotional prosody, a suprasegmental component of language, is predominantly processed by right temporo-frontal areas of the cerebral cortex. In temporal lobe epilepsy (TLE), brain disturbances affecting prosody processing frequently occur. This research assesses compensatory brain mechanisms of prosody processing in refractory TLE using fMRI. Read More

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Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy.

Epilepsia 2022 May 20. Epub 2022 May 20.

Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan.

Objective: Motivated by the challenges raised by diagnosing poststroke epilepsy (PSE), especially in nonmotor onset seizure (non-MOS), we aimed to investigate the features of non-MOS, including seizure sequences, patient characteristics, and electrophysiological and imaging findings in PSE.

Methods: This observational cohort study enrolled patients with PSE whose seizure onset was witnessed. According to the International League Against Epilepsy (ILAE) 2017 seizure classification, we classified seizure-onset symptoms into the non-MOS and MOS groups. Read More

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Theory of Mind and Empathy in Adults With Epilepsy: A Meta-Analysis.

Front Psychiatry 2022 27;13:877957. Epub 2022 Apr 27.

Department of Central Laboratory, Yancheng Third People's Hospital, The Sixth Affiliated Hospital of Nantong University, Yancheng, China.

Mounting evidence suggests that social cognitive abilities [including theory of mind (ToM) and empathy] are impaired in adult patients with epilepsy. Although the deficits in overall ToM in epilepsy have been documented well, the effects of epilepsy on empathic ability and specific subcomponents of ToM remain unclear. The primary aim of this study was to provide the first meta-analytic integration of ToM and empathy in adult patients with epilepsy, and to decompose these constructs to clearly differentiate their distinct (cognitive ToM and affective empathy) and overlapping (affective ToM/cognitive empathy) components. Read More

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Auditory aura from the hippocampus - Not all that 'rings' is neocortical temporal lobe epilepsy.

Epilepsy Behav Rep 2022 27;19:100548. Epub 2022 Apr 27.

Department of Neurology, Apollo Hospitals, Seshadripuram, Bangalore, India.

Epileptic auras provide the initial clues to identify the probable region of ictal onset. In temporal lobe epilepsies, auras are most commonly experiential or viscerosensory, when they arise from mesial structures. Whereas sensations such as vertigo and auditory hallucinations are more likely to occur from the lateral temporal lobe structures. Read More

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Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures.

Prog Neurobiol 2022 07 12;214:102286. Epub 2022 May 12.

Department of Pharmacology & Physiology, Georgetown University, Washington DC, USA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington DC, USA; Department of Neuroscience, Georgetown University, Washington DC, USA. Electronic address:

There is a large unmet need for improved treatment for temporal lobe epilepsy (TLE); circuit-specific manipulation that disrupts the initiation and propagation of seizures is promising in this regard. The midline thalamus, including the mediodorsal nucleus (MD) is a critical distributor of seizure activity, but its afferent and efferent pathways that mediate seizure activity are unknown. Here, we used chemogenetics to silence input and output projections of the MD to discrete regions of the frontal cortex in the kindling model of TLE in rats. Read More

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Factors associated with preoperative and postoperative seizures in patients undergoing resection of brain metastases.

J Neurosurg 2022 Apr 29:1-8. Epub 2022 Apr 29.

1Department of Neurological Surgery and.

Objective: Epileptic seizures are a common and potentially devastating complication of metastatic brain tumors. Although tumor-related seizures have been described in previous case series, most studies have focused on primary brain tumors and have not differentiated between different types of cerebral metastases. The authors analyzed a large surgical cohort of patients with brain metastases to examine risk factors associated with preoperative and postoperative seizures and to better understand the seizure risk factors of metastatic brain tumors. Read More

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Religious conversion in an older male with longstanding epilepsy.

Epilepsy Behav Rep 2022 20;18:100524. Epub 2022 Jan 20.

NYU Comprehensive Epilepsy Center, 223 East 34 Street, New York, NY 10016, USA.

Religious experiences in epilepsy patients have provoked much interest with suggestions that hyperreligiosity is associated with temporal lobe seizures. Extreme varieties of religious behavior may be more frequent in epilepsy patients during ictal activity or during post-ictal psychotic episodes. We report a 75 year-old man with epilepsy who developed a progressive decline in cognition and behavior following a religious conversion 15 years earlier. Read More

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January 2022

Ultrasonic vocalizations - Novel seizure-related manifestation in rats.

Epilepsy Res 2022 Jul 22;183:106927. Epub 2022 Apr 22.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address:

Objective: Seizures of frontal or temporal lobe origin can associate with vocalizations in humans. Our objective was to assess whether rats emit specific seizure-related patterns of ultrasonic vocalizations (USVs) during seizures and epileptiform activity.

Methods: Adult male Sprague-Dawley rats were treated with a single administration of pentylenetetrazol (PTZ, 50 mg/kg, i. Read More

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The β2 nicotinic subunit linked to sleep-related epilepsy differently affects fast-spiking and regular spiking somatostatin-expressing neurons in murine prefrontal cortex.

Prog Neurobiol 2022 07 2;214:102279. Epub 2022 May 2.

Department of Biotechnology and Biosciences, University of Milano-Bicocca and NeuroMI, Milan Center of Neuroscience, 20126 Milan, Italy. Electronic address:

Mutant subunits of the neuronal nicotinic ACh receptor (nAChR) can cause Autosomal Dominant Sleep-related Hypermotor Epilepsy (ADSHE), characterized by frontal seizures during non-rapid eye movement (NREM) sleep. We studied the cellular bases of the pathogenesis in brain slices from mice conditionally expressing the ADSHE-linked β2 nAChR subunit. β2 mice displayed minor structural alterations, except for a ~10% decrease of prefrontal cortex thickness. Read More

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Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.

Brain 2022 May 2. Epub 2022 May 2.

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, Quebec H3A 2B4, Canada.

Cognitive impairment is a common comorbidity of epilepsy, and adversely impacts people with both frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE). While its neural substrates have been extensively investigated in TLE, functional imaging studies in FLE are scarce. In this study, we profiled the neural processes underlying cognitive impairment in FLE, and directly compared FLE and TLE to establish commonalities and differences. Read More

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Good seizure outcome after focal resection surgery for super-refractory status epilepticus: Report of two cases.

Surg Neurol Int 2022 22;13:164. Epub 2022 Apr 22.

Department of Neurosurgery, Harasanshin Hospital, Fukuoka, Japan.

Background: There is scarce evidence regarding focal resection surgery for super-refractory status epilepticus (SRSE), which is resistant to general anesthetic treatment over 24 h. We report two patients with SRSE, in whom good seizure outcomes were obtained following focal resection surgery.

Case Description: Patient 1: A 58-year-old man who underwent left anterior temporal lobectomy with hippocampectomy at the age of 38 years after being diagnosed left medial temporal lobe epilepsy. Read More

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Cortical remodeling before and after successful temporal lobe epilepsy surgery.

Acta Neurol Scand 2022 May 4. Epub 2022 May 4.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: To explore dynamic alterations of cortical thickness before and after successful anterior temporal lobectomy (ATL) in patients with unilateral mesial temporal lobe epilepsy (mTLE).

Materials And Methods: High-resolution T1-weighted MRI was obtained in 28 mTLE patients who achieved seizure freedom for at least 24 months after ATL and 29 healthy controls. Patients were scanned at five timepoints, including before surgery, 3, 6, 12 and 24 months after surgery. Read More

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Subacute encephalitis in an immunocompetent patient diagnosed by next-generation sequencing.

J Int Med Res 2022 May;50(5):3000605221093217

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

is a free-living heterotrophic amoeba found in soil that causes a rare and usually fatal granulomatous amebic encephalitis. We report an immunocompetent patient infected with encephalitis diagnosed by next-generation sequencing (NGS). Clinical manifestations included sudden headache and epilepsy with disturbance of consciousness. Read More

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Neurocognitive Outcome and Seizure Freedom After Awake Surgery of Gliomas.

Front Oncol 2022 7;12:815733. Epub 2022 Apr 7.

Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt/Main, Germany.

Objectives: Gliomas are often diagnosed due to epileptic seizures as well as neurocognitive deficits. First treatment choice for patients with gliomas in speech-related areas is awake surgery, which aims at maximizing tumor resection while preserving or improving patient's neurological status. The present study aimed at evaluating neurocognitive functioning and occurrence of epileptic seizures in patients suffering from gliomas located in language-related areas before and after awake surgery as well as during their follow up course of disease. Read More

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Sequential Semiology of Seizures and Brain Perfusion Patterns in Patients with Drug-Resistant Focal Epilepsies: A Perspective from Neural Networks.

Behav Sci (Basel) 2022 Apr 14;12(4). Epub 2022 Apr 14.

Cuban Neurosciences Center, 25th Ave, No 15202, Playa, Havana 11300, Cuba.

Ictal semiology and brain single-photon emission computed tomography have been performed in approaching the epileptogenic zone in drug-resistant focal epilepsies. The authors aim to describe the brain structures involved in the ictal and interictal epileptogenic network from sequential semiology and brain perfusion quantitative patterns analysis. A sequential representation of seizures was performed (n = 15). Read More

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Cognitive phenotypes in frontal lobe epilepsy.

Epilepsia 2022 Apr 16. Epub 2022 Apr 16.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Objective: Neuropsychological profiles are heterogeneous both across and within epilepsy syndromes, but especially in frontal lobe epilepsy (FLE), which has complex semiology and epileptogenicity. This study aimed to characterize the cognitive heterogeneity within FLE by identifying cognitive phenotypes and determining their demographic and clinical characteristics.

Method: One hundred and six patients (age 16-66; 44% female) with FLE completed comprehensive neuropsychological testing, including measures within five cognitive domains: language, attention, executive function, processing speed, and verbal/visual learning. Read More

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Parietal and medial temporal lobe interactions in working memory goal-directed behavior.

Cortex 2022 05 8;150:126-136. Epub 2022 Mar 8.

Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea; Department of Neurosurgery, Seoul National University College of Medicine and Hospital, Seoul, South Korea; Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, South Korea. Electronic address:

Working memory is essential for the organization of goal-directed behavior, which involves multiple brain networks. The frontoparietal network has been proposed as a central node for the maintenance and manipulation of information. However, the exact contribution of the frontal and parietal lobes is still unclear as is that of the medial temporal lobe (MTL). Read More

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Automatic seizure detection and seizure pattern morphology.

Clin Neurophysiol 2022 06 18;138:214-220. Epub 2022 Mar 18.

Department of Neurology, Clinic Hietzing, Vienna, Austria; Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria; Medical Faculty, Sigmund Freud University, Vienna, Austria.

Objective: We studied the influence of seizure pattern morphology on detection rate and detection delay of an automatic seizure detection system. We correlated seizure pattern morphology with seizure onset zone and assessed the influence of seizure onset zone on the performance of the seizure detection system.

Methods: We analyzed 10. Read More

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A novel missense creatine mutant of , c.464G>A (p.G155D), associated with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), reduces the expression of CaBP4.

Transl Pediatr 2022 Mar;11(3):396-402

Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Academy of Neuroscience, Guangzhou, China.

Background: encodes Ca-binding protein 4, a neuronal Ca-binding protein that participates in many cellular processes by regulating the concentration of free Ca ions. variants have been identified as a cause of congenital stationary night blindness (CSNB). However, we recently reported a 4-generation pedigree with 11 individuals diagnosed with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) that were validated with only one novel missense mutation, c. Read More

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