4,389 results match your criteria Frontal Lobe Epilepsy


Language network reorganization before and after temporal lobe epilepsy surgery.

J Neurosurg 2020 Jul 3:1-9. Epub 2020 Jul 3.

Departments of1Biomedical Imaging and Image-guided Therapy.

Objective: Epilepsy surgery is the recommended treatment option for patients with drug-resistant temporal lobe epilepsy (TLE). This method offers a good chance of seizure freedom but carries a considerable risk of postoperative language impairment. The extremely variable neurocognitive profiles in surgical epilepsy patients cannot be fully explained by extent of resection, fiber integrity, or current task-based functional MRI (fMRI). Read More

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http://dx.doi.org/10.3171/2020.4.JNS193401DOI Listing

Pharyngeal dysesthesias as aura in epilepsy localized to the non-dominant frontal operculum misdiagnosed as non-epileptic seizures.

Neurocase 2020 Jul 2:1-4. Epub 2020 Jul 2.

Department of Neurology, University of South Alabama Medical Center , Mobile, AL, USA.

The diagnosis of atypical paroxysmal events represents a significant challenge for clinicians when differentiating epileptic from nonepileptic events. The ictal manifestations of pharyngeal dysesthesias are often misdiagnosed and difficult to distinguish clinically, given their subtle features such as pharyngeal discomfort with and without autonomic symptomology. We report a rare case of isolated ictal pharyngeal dysesthesias localizing to the non-dominant frontal operculum lobe misdiagnosed as psychogenic and later confirmed by continuous video-EEG monitoring. Read More

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http://dx.doi.org/10.1080/13554794.2020.1789177DOI Listing

Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients.

Front Neurol 2020 2;11:479. Epub 2020 Jun 2.

Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Magnetoencephalography source imaging (MSI) of interictal epileptiform discharges (IED) is a useful presurgical tool in the evaluation of drug-resistant frontal lobe epilepsy (FLE) patients. Yet, failures in MSI can arise related to artifacts and to interference of background activity. Independent component analysis (ICA) is a popular denoising procedure but its clinical application remains challenging, as the selection of multiple independent components (IC) is controversial, operator dependent, and time consuming. Read More

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http://dx.doi.org/10.3389/fneur.2020.00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280485PMC

Stanford type a aortic dissection with cerebral infarction: a rare case report.

BMC Neurol 2020 Jun 23;20(1):253. Epub 2020 Jun 23.

Department of Neurology, Chongqing City Hospital of Traditional Chinese Medicine, No. 6, Seventh Branch Road, Panxi, Jiangbei District, Chong qing, 400021, China.

Background: Aortic dissection (AoD) is a disease with a high mortality rate. Its clinical manifestations are diverse and covert, which makes diagnosis and treatment challenging. Here, we report a very rare case of aortic dissection leading to bilateral cerebral cortex ischaemia and epilepsy. Read More

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http://dx.doi.org/10.1186/s12883-020-01832-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313114PMC

[A Case of Anterior Cranial Fossa Dural Arteriovenous Fistula Involving Uncontrolled Seizures Diagnosed Based on Characteristic Findings on Arterial Spin-labeling Imaging].

No Shinkei Geka 2020 Jun;48(6):547-552

Department of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki.

We report a case of anterior cranial fossa dural arteriovenous fistula(ACF-DAVF)in a patient whose diagnosis was made according to characteristic findings on arterial spin labeling(ASL)MRI. CASE:A 68-year-old man was admitted to our hospital because of intractable epilepsy. Based on the initial MRI findings, an initial diagnosis of limbic encephalitis was made. Read More

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http://dx.doi.org/10.11477/mf.1436204226DOI Listing

Who seizes longest? Impact of clinical and demographic factors.

Epilepsia 2020 Jun 21. Epub 2020 Jun 21.

Department of Neurology, Epilepsy Center, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: To investigate the impact of clinical and demographic parameters on the duration of focal onset seizures with and without secondary generalization using precise duration measurements from intracranial electroencephalographic (iEEG) recordings.

Methods: Patients with unifocal epilepsy syndromes and iEEG recording were retrospectively identified from the database of the local epilepsy center (2006-2016). Seizure duration was defined as time difference of iEEG seizure pattern onset and cessation. Read More

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http://dx.doi.org/10.1111/epi.16577DOI Listing

Investigation of poststroke epilepsy (INPOSE) study: a multicenter prospective study for prediction of poststroke epilepsy.

J Neurol 2020 Jun 19. Epub 2020 Jun 19.

Department of Neurosurgery, Nara Medical University, 840, Shijo-cho, Kashihara, Nara, Japan.

Background And Purpose: Poststroke epilepsy is a common problem in clinical practice. This study aimed to determine the predictors of poststroke epilepsy and to identify the risk factors.

Methods: A total of 436 patients were enrolled for this study. Read More

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http://dx.doi.org/10.1007/s00415-020-09982-2DOI Listing

Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.

Epilepsy Behav 2020 Jun 13;110:107172. Epub 2020 Jun 13.

Neuroscience Training Program, University of Wisconsin-Madison, United States of America; Department of Medical Physics, University of Wisconsin-Madison, United States of America; Department of Radiology, University of Wisconsin-Madison, United States of America.

Neuroticism, a core personality trait characterized by a tendency towards experiencing negative affect, has been reported to be higher in people with temporal lobe epilepsy (TLE) compared with healthy individuals. Neuroticism is a known predictor of depression and anxiety, which also occur more frequently in people with TLE. The purpose of this study was to identify abnormalities in whole-brain resting-state functional connectivity in relation to neuroticism in people with TLE and to determine the degree of unique versus shared patterns of abnormal connectivity in relation to elevated symptoms of depression and anxiety. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107172DOI Listing

Catching the imposter in the brain: The case of Capgras delusion.

Cortex 2020 May 19. Epub 2020 May 19.

CNR Neuroscience Institute, Parma, Italy.

Here we describe a rare case of Capgras delusion - a misidentification syndrome characterized by the belief that a person has been replaced by an imposter - in a patient without evident neurological or psychiatric symptoms. Intriguingly, delusional belief was selective for both person and modality, as the patient believed that his son - not his daughter or other relatives - was substituted with an imposter only while being in presence of him and looking at his face, but not when merely listening to his voice. A neuroanatomical reconstruction obtained integrating morphological and functional patient's neuroimaging data highlighted two main peculiarities: a compression of the rostral portion of right temporal lobe due to a large arachnoid cyst, and a bilaterally reduced metabolism of frontal areas. Read More

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http://dx.doi.org/10.1016/j.cortex.2020.04.025DOI Listing

Effect of total callosotomy on KCNQ2-related intractable epilepsy.

Brain Dev 2020 Jun 9. Epub 2020 Jun 9.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-2606, Japan.

Aim: To describe beneficial effects of callosotomy on KCNQ2-related intractable epilepsy.

Case Report: Our patient was a 10-year-old girl who had developed epilepsy during the neonatal period, accompanied by a suppression-burst pattern on the electroencephalography (EEG). The patient showed profound psychomotor developmental delay since early infancy. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.05.005DOI Listing

Networks in Frontal Lobe Epilepsy.

Authors:
Niravkumar Barot

Neurosurg Clin N Am 2020 Jul 16;31(3):319-324. Epub 2020 Apr 16.

University of Pittsburgh, Kaufmann Medical Building, 3471 Fifth Avenues, Suite 810, Pittsburgh, PA 15213, USA. Electronic address:

Epilepsy affects about 1% of the general population. Frontal lobe epilepsy is the second most common focal epilepsy accounting for nearly 25% of medically refractory epilepsies. This paper reviews frontal lobe epilepsy from a perspective of a network disease that may help us to understand epilepsy from the microscale of genes, to local neuronal circuits, to the macrolevel of a whole-brain network. Read More

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http://dx.doi.org/10.1016/j.nec.2020.03.001DOI Listing

History of the Network Approach in Epilepsy Surgery.

Neurosurg Clin N Am 2020 Jul;31(3):301-308

Department of Neurological Surgery, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA. Electronic address:

We provide a history and overview of the network approach to epilepsy surgery. Models of the epileptogenic zone (EZ) have evolved considerably over the years with more recent models accounting for the connectivity and network properties of epileptic foci. Next, we describe several examples of network phenotypes of focal epilepsy and how these have the potential to influence surgical decision-making and patient outcome. Read More

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http://dx.doi.org/10.1016/j.nec.2020.03.011DOI Listing

Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study.

J Neuroimaging 2020 May 30. Epub 2020 May 30.

Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

Background And Purpose: In 30% of the patients with focal epilepsy, an epileptogenic lesion cannot be visually detected with structural MRI. Ultra-high field MRI may be able to identify subtle pathology related to the epileptic focus. We set out to assess 7T MRI-derived volumetric and functional activity lateralization of the hippocampus, hippocampal subfields, temporal and frontal lobe in healthy subjects and MRI-negative patients with focal epilepsy. Read More

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http://dx.doi.org/10.1111/jon.12739DOI Listing

Epidemiology of traumatic brain injury-associated epilepsy in western China: An analysis of multicenter data.

Epilepsy Res 2020 Aug 11;164:106354. Epub 2020 May 11.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Objectives: This study aims to explore the probability of developing posttraumatic epilepsy (PTE) in the following 8 years after traumatic brain injury (TBI), the risk factors associated with PTE and its cumulative prevalence.

Methods: This is a retrospective follow-up study of patients with traumatic brain injury (TBI) discharged from the West China Hospital between January 1, 2011 and December 31, 2017, Chengdu Shang Jin Nan Fu Hospital and Sichuan Provincial People's Hospital from January 1, 2013 to March 1, 2015. We used forward stepwise method to build the final multivariate cox proportional hazard regression model to obtain estimates of hazard ratio (HR) of PTE and 95% confidence intervals (CI). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106354DOI Listing

Aphasic status epilepticus of frontal origin treated by resective surgery.

Epilepsy Behav Rep 2020 23;14:100359. Epub 2020 Mar 23.

Department of Neurological Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.

Aphasic status epilepticus (SE) is a clinical entity of SE, but it has not been well recognized. We report a 43-year-old female with a chronic drug-resistant epilepsy with aphasic SE, treated by resective surgery. The patient showed long-lasting weekly episodes of hypokinesia, slow verbal response, and dysphasia, which were diagnosed as symptoms of aphasic SE. Read More

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http://dx.doi.org/10.1016/j.ebr.2020.100359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229485PMC

Theta oscillation and functional connectivity alterations related to executive control in temporal lobe epilepsy with comorbid depression.

Clin Neurophysiol 2020 Jul 29;131(7):1599-1609. Epub 2020 Apr 29.

Department of Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Objective: Depression is widely acknowledged as the most common comorbidity of temporal lobe epilepsy (TLE), and executive control (EC) may be particularly impaired in patients with TLE with comorbid depression. The purpose of this study was to investigate brain network alterations in patients with TLE with or without depression using scalp electroencephalography (EEG), and to explore the potential mechanisms of TLE with comorbid depression.

Methods: Forty patients with TLE and 20 healthy controls (HC) were recruited for administered the BDI-II and HAMD-17 surveys. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.038DOI Listing

Identifying the characteristics of brain glucose metabolism using normal F-FDG PET database in patients with temporal lobe epilepsy.

Neurol Sci 2020 May 6. Epub 2020 May 6.

Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: This study aimed to measure the global brain glucose metabolism of patients with temporal lobe epilepsy (TLE) using MIMneuro software based on the normal brain glucose metabolism database.

Methods: In this cross-sectional study, 23 patients (11 males and 12 females, mean age 25.6 ± 10. Read More

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http://dx.doi.org/10.1007/s10072-020-04426-1DOI Listing

Gelastic seizures: a retrospective study in five tertiary hospital centres.

Epileptic Disord 2020 Apr;22(2):165-175

Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN), Lisbon,, Faculdade de Medicina, Universidade de Lisboa, Lisbon.

This study aimed to characterize, clinically and neurophysiologically, a series of patients with gelastic seizures (GS), including both adults and children. We retrospectively collected patients with GS from epilepsy clinics of five tertiary hospital centres within a single country. Patients were selected through relatives'/caregivers' descriptions, home video and/or video-EEG monitoring. Read More

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http://dx.doi.org/10.1684/epd.2020.1153DOI Listing

Massive Ossification with Hematopoietic Marrow on Both Surfaces of the Expanded Polytetrafluoroethylene Artificial Dura Mater.

World Neurosurg 2020 Apr 25;139:405-409. Epub 2020 Apr 25.

Department of Neurosurgery, Kyushu Rosai Hospital, Kitakyushu, Japan. Electronic address:

Background: Artificial dural substitute made from an expanded polytetrafluoroethylene (ePTFE) sheet has been widely used in surgical application.

Case Description: We describe a 19-year-old woman in whom massive ossification with hematopoietic marrow was noted on both surfaces of an ePTFE sheet during epilepsy surgery. At age 8, she underwent decompressive craniectomy for a ruptured arteriovenous malformation in the right frontal lobe, followed by duraplasty with an ePTFE sheet and autologous cranioplasty fixed with titanium miniplates. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.068DOI Listing

Glial fibrillary acidic protein (GFAP)-antibody in children with focal seizures of undetermined cause.

Acta Neurol Belg 2020 Apr 24. Epub 2020 Apr 24.

Department of Neuroscience, Aziz Sancar Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey.

Anti-neuronal antibodies that are related with autoimmune encephalitis syndromes may also be found in children with new onset seizures or chronic epilepsy. To unravel the significance of autoimmune astrocytopathy in epilepsy, we investigated serum antibody to glial fibrillary acidic protein (GFAP), another autoantigen described in autoimmune encephalitis with seizures, in 38 children with focal seizures of undetermined cause. GFAP antibody was screened with cell based assay and indirect immunohistochemistry and was found in two boys with normal brain MRI and unrevealing medical history prior to seizures. Read More

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http://dx.doi.org/10.1007/s13760-020-01361-yDOI Listing

Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients.

Brain Imaging Behav 2020 Apr 21. Epub 2020 Apr 21.

Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510,515, China.

Growing evidence has supported that the nucleus accumbens (NAc), especially its shell portion, has been involved in epileptogenesis. However, relevant studies on vivo human brain are quite limited. In this study, we investigated left mesial temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc subregions using resting-state functional magnetic resonance imaging. Read More

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http://dx.doi.org/10.1007/s11682-019-00217-1DOI Listing
April 2020
3.385 Impact Factor

Pseudoanginal chest pain associated with vagal nerve stimulation: a case report.

BMC Neurol 2020 Apr 20;20(1):144. Epub 2020 Apr 20.

Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, USA.

Background: Vagal nerve stimulation (VNS) can be an effective therapy for patients with epilepsy refractory to anti-epileptic drugs or intracranial surgery. While generally well tolerated, it has been associated with laryngospasm, hoarseness, coughing, dyspnea, throat and atypical chest pain, cardiac symptoms such as bradycardia and occasionally asystole. We report on a patient receiving vagal nerve stimulation who experienced severe typical anginal chest pain during VNS firing without any evidence of cardiac ischemia or dysfunction. Read More

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http://dx.doi.org/10.1186/s12883-020-01693-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171733PMC

Rhythmic Network Modulation to Thalamocortical Couplings in Epilepsy.

Int J Neural Syst 2020 Apr 18:2050014. Epub 2020 Apr 18.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.

Thalamus interacts with cortical areas, generating oscillations characterized by their rhythm and levels of synchrony. However, little is known of what function the rhythmic dynamic may serve in thalamocortical couplings. This work introduced a general approach to investigate the modulatory contribution of rhythmic scalp network to the thalamo-frontal couplings in juvenile myoclonic epilepsy (JME) and frontal lobe epilepsy (FLE). Read More

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http://dx.doi.org/10.1142/S0129065720500148DOI Listing

Praxis-induced reflex seizures in two Japanese cases with ring chromosome 20 syndrome.

Epileptic Disord 2020 Apr;22(2):214-218

Department of Paediatrics, Jichi Medical University, Shimotsuke, Japan.

Ring chromosome 20 syndrome is an epileptic and neurodevelopmental encephalopathy that occurs in children, characterised by a triad of refractory frontal lobe seizures, recurrent non-convulsive status epilepticus and frontal lobe-dominant paroxysmal discharges. However, details of other clinical features associated with ring chromosome 20 syndrome remain unknown. Here, we report two patients with ring chromosome 20 syndrome who had praxis-induced reflex seizures. Read More

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http://dx.doi.org/10.1684/epd.2020.1146DOI Listing

Aberrant functional connectivity of the cingulate subregions in right-sided temporal lobe epilepsy.

Exp Ther Med 2020 Apr 25;19(4):2901-2912. Epub 2020 Feb 25.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

Patients with temporal lobe epilepsy (TLE) have been indicated to exhibit abnormal resting-state functional connectivity (rsFC) of the cingulate cortex. However, it has remained elusive whether cingulate subregions show different connectivity patterns in TLE. The present study aimed to investigate the differences in rsFC of each cingulate subregion between patients with right-sided TLE (rTLE) and healthy controls (HCs), as well as their association with executive control performance in rTLE. Read More

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http://dx.doi.org/10.3892/etm.2020.8551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086282PMC

Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.

Brain Dev 2020 Jun 1;42(6):473-476. Epub 2020 Apr 1.

Department of Pediatrics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Background: Ring chromosome 20 syndrome is a rare chromosomal disorder characterized by refractory seizure, mental retardation, and behavioral problems. Although there are reports of the effective treatment of patients with antiepileptic drugs (AEDs), no study has reported the effects of lacosamide(LCM) in children with this syndrome. We report a 7-year-old boy with this syndrome whose refractory and behavioral abnormalities have been remarkably improved by treatment with LCM. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.03.003DOI Listing

Unilateral prefrontal lobotomy for epilepsy: technique and surgical anatomy.

Neurosurg Focus 2020 04;48(4):E10

1Department of Neurosurgery, University Hospital of Lausanne.

Objective: Surgery for frontal lobe epilepsy remains a challenge because of the variable seizure outcomes after surgery. Disconnective procedures are increasingly applied to isolate the epileptogenic focus and avoid complications related to extensive brain resection. Previously, the authors described the anterior quadrant disconnection procedure to treat large frontal lobe lesions extending up to but not involving the primary motor cortex. Read More

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http://dx.doi.org/10.3171/2020.1.FOCUS19938DOI Listing
April 2020
2.105 Impact Factor

Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study.

Cereb Cortex 2020 Jun;30(8):4633-4650

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

In the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity between the inferior frontal gyrus (IFG) and the lateral part of the temporal and parietal lobes, we integrated spatiotemporal profiles of cortico-cortical evoked potentials (CCEPs) recorded intraoperatively in 14 patients who had undergone surgical resection for a brain tumor or epileptic focus. Four-dimensional visualization of the combined CCEP data showed that the pars opercularis (Broca's area) is connected to the posterior temporal cortices and the supramarginal gyrus, whereas the pars orbitalis is connected to the anterior lateral temporal cortices and angular gyrus. Read More

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http://dx.doi.org/10.1093/cercor/bhaa065DOI Listing

Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.

Front Neurol 2020 10;11:144. Epub 2020 Mar 10.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.

Genetic generalized epilepsies (GGE), previously called idiopathic generalized epilepsies, constitute about 20% of all epilepsies, and include childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and epilepsy with generalized tonic-clonic seizures alone (CAE, JAE, JME, and GGE-GTCS, respectively). GGE are characterized by high heritability, likely underlain by polygenetic mechanisms, which may relate to atypical neurodevelopmental trajectories. Age of onset ranges from pre-school years, for CAE, to early adulthood for GGE-GTCS. Read More

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http://dx.doi.org/10.3389/fneur.2020.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076110PMC

[Clinical and neuropsychological studies of patients before and after insular glioma resection].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(1):43-54

Burdenko Neurosurgical Center, Moscow, Russia.

Aim: The study was aimed to investigate the insula function based on analysis and comparison of epileptic seizures (irritation symptoms) and cognitive impairment (memory loss) in patients with insular gliomas.

Material And Methods: Epileptic seizures and cognitive impairment were analyzed in 51 patients with insular gliomas before and after surgery. The tumor was located on the left in 21 patients and on the right - in 30. Read More

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http://dx.doi.org/10.17116/neiro20208401143DOI Listing
January 2020

Deep Brain Stimulation of Anterior Thalamic Nucleus for Treatment of Patient with Tuberous Sclerosis-Related Refractory Epilepsy.

World Neurosurg 2020 Jun 10;138:141-144. Epub 2020 Mar 10.

Department of Neurosurgery, Qilu Hospital of Shandong University (Qingdao), Qingdao, P.R. China. Electronic address:

Background: Neuromodulation is recommended for patients with refractory tuberous sclerosis related epilepsy (TRE) who are unable to localize epileptogenic nodules after comprehensive preoperative evaluation or for patients and families who do not agree to resection.

Case Description: We report a patient with refractory TRE who received deep brain stimulation of anterior thalamic nucleus (ANT-DBS) and achieved a satisfactory response. To our knowledge, this is the first case of TRE being treated with ANT-DBS. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.010DOI Listing

Predictors of early postoperative epileptic seizures after awake surgery in supratentorial diffuse gliomas.

J Neurosurg 2020 Mar 13:1-10. Epub 2020 Mar 13.

1Department of Neurosurgery, Sainte-Anne Hospital, Paris.

Objective: Functional-based resection under awake conditions had been associated with a nonnegligible rate of intraoperative and postoperative epileptic seizures. The authors assessed the incidence of intraoperative and early postoperative epileptic seizures after functional-based resection under awake conditions.

Methods: The authors prospectively assessed intraoperative and postoperative seizures (within 1 month) together with clinical, imaging, surgical, histopathological, and follow-up data for 202 consecutive diffuse glioma adult patients who underwent a functional-based resection under awake conditions. Read More

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http://dx.doi.org/10.3171/2020.1.JNS192774DOI Listing

Rhythmic rocking stereotypies in frontal lobe seizures: A quantified video study.

Neurophysiol Clin 2020 Apr 4;50(2):75-80. Epub 2020 Mar 4.

Inserm, INS (institut de neurosciences des systèmes), Aix-Marseille université, 13005 Marseille, France; Service de neurophysiologie clinique, hôpital de la Timone, AP-HM, 13005 Marseille, France. Electronic address:

Objectives: Rhythmic, stereotyped movements occur in some epileptic seizures. We aimed to document time-evolving frequencies of antero-posterior rocking occurring during prefrontal seizures, using a quantitative video analysis.

Methods: Six seizures from 3 patients with prefrontal epilepsy yet different sublobar localizations were analyzed using a deep learning-based head-tracking method. Read More

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http://dx.doi.org/10.1016/j.neucli.2020.02.003DOI Listing

Clinical characteristics of antiNmethylaspartate receptor encephalitis in children.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jan;45(1):47-54

Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objectives: To analyze the clinical characteristics and prognosis of children with anti-N-methyl--aspartate receptor (NMDAR) encephalitis and to provide a basis for early clinical identification of this disease.

Methods: The clinical data of 42 cases of anti-NMDAR encephalitis at Department of Pediatrics, Second Xiangya Hospital, Central South University from January 2015 to March 2018 were collected. The clinical features and followed-up outcomes were analyzed retrospectively. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180761DOI Listing
January 2020

The understanding of mental states and the cognitive phenotype of frontal lobe epilepsy.

Epilepsia 2020 Apr 3;61(4):747-757. Epub 2020 Mar 3.

Department of Diagnostics and Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Objective: Previous studies of frontal lobe epilepsy (FLE) have documented different impairments of theory of mind (ToM), while the study of frontal lobe (FL) lesion without seizures has produced inconsistent results. Given the role played by the FLs in ToM, we evaluated this and other functions in patients with FLE with and without FL lesions. The main objective was to clarify the salience of ToM impairment in the cognitive pattern of FLE and its capacity to discriminate these patients from healthy subjects. Read More

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http://dx.doi.org/10.1111/epi.16457DOI Listing

Concordance Between Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging (MRI) Derived Localization of Language in a Clinical Cohort.

J Child Neurol 2020 May 3;35(6):363-379. Epub 2020 Mar 3.

Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.

Transcranial magnetic stimulation (TMS) is a newer noninvasive language mapping tool that is safe and well-tolerated by children. We examined the accuracy of TMS-derived language maps in a clinical cohort by comparing it against functional magnetic resonance imaging (MRI)-derived language map. The number of TMS-induced speech disruptions and the volume of activation during functional MRI tasks were localized to Brodmann areas for each modality in 40 patients with epilepsy or brain tumor. Read More

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http://dx.doi.org/10.1177/0883073820901415DOI Listing

An empirical assessment of appearance descriptors applied to MRI for automated diagnosis of TLE and MCI.

Comput Biol Med 2020 Feb 23;117:103592. Epub 2019 Dec 23.

Department of Computer Science, University of Salzburg, Austria. Electronic address:

Objective: Differential diagnosis of mild cognitive impairment MCI and temporal lobe epilepsy TLE is a debated issue, specifically because these conditions may coincide in the elderly population. We evaluate automated differential diagnosis based on characteristics derived from structural brain MRI of different brain regions.

Methods: In 22 healthy controls, 19 patients with MCI, and 17 patients with TLE we used scale invariant feature transform (SIFT), local binary patterns (LBP), and wavelet-based features and investigate their predictive performance for MCI and TLE. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.103592DOI Listing
February 2020

Two mutations in the nicotinic acetylcholine receptor subunit A4 (CHRNA4) in a family with autosomal dominant sleep-related hypermotor epilepsy.

Epileptic Disord 2020 Feb;22(1):116-119

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster.

Sleep-related hypermotor epilepsy, or nocturnal frontal lobe epilepsy, as it was formerly called, is a focal epilepsy with mostly sleep-related seizures of hypermotor, tonic or dystonic semiology. Sleep-related hypermotor epilepsy may be attributed to a monogenetic cause with autosomal dominant inheritance. Mutations are described in different genes, including the genes for three subunits of the nicotinic acetylcholine receptor. Read More

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http://dx.doi.org/10.1684/epd.2020.1140DOI Listing
February 2020

Sexual functions in women with focal epilepsy: Relationship to demographic, clinical, hormonal and psychological variables.

Clin Neurol Neurosurg 2020 Apr 30;191:105697. Epub 2020 Jan 30.

Department of Clinical Pathology, Assiut University Hospital, Assiut, Egypt.

Objectives: Sexual dysfunctions [SDs] are common in women with epilepsy [WWE] but related studies were neglected in our locality. We aimed to determine the frequencies and severities of SDs and their clinical, hormonal and psychological determinants in WWE.

Patients And Methods: This study included 120 adults [mean age: 36. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105697DOI Listing

Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy.

Front Neurol 2019 17;10:1398. Epub 2020 Jan 17.

Laboratory of Neuroimaging, Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.

Major Depressive Disorder (MDD) is highly prevalent in patients with mesial temporal lobe epilepsy (MTLE), especially in women, carrying significant morbidity. This study aimed to investigate the cortical thickness (CT) abnormalities associated with MDD in women with MTLE and hippocampal atrophy (HA). Also, we investigated the impact of MDD upon the volumes of the hippocampus and amygdala in these patients. Read More

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http://dx.doi.org/10.3389/fneur.2019.01398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979005PMC
January 2020

Therapy in Sleep-Related Hypermotor Epilepsy (SHE).

Curr Treat Options Neurol 2020 Jan 30;22(1). Epub 2020 Jan 30.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Purpose Of Review: The purpose of this review is to summarize and discuss current options and new advances in the treatment of sleep-related hypermotor epilepsy (SHE), focusing on pharmacological and surgical treatments.

Recent Findings: Carbamazepine (CBZ) has traditionally been regarded as the first-line treatment option in SHE patients. In patients showing an unsatisfactory response to monotherapy, topiramate (TPM), lacosamide (LCM) and acetazolamide (ACZ) could be reasonable add-on strategies. Read More

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http://dx.doi.org/10.1007/s11940-020-0610-1DOI Listing
January 2020

Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.

CNS Drugs 2020 Feb;34(2):147-161

Scottish Epilepsy Initiative, Glasgow, UK.

Common genetic generalised epilepsy syndromes encountered by clinicians include childhood and juvenile absence epilepsies, juvenile myoclonic epilepsy and generalised tonic-clonic seizures on awakening. Treatment of these syndromes involves largely the use of broad-spectrum antiseizure drugs. Those effective for the generalised epilepsies include sodium valproate, phenobarbital, ethosuximide, clobazam, clonazepam, lamotrigine, levetiracetam, topiramate, zonisamide and, more recently, perampanel and brivaracetam. Read More

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http://dx.doi.org/10.1007/s40263-020-00698-5DOI Listing
February 2020

Sleep related epilepsy in focal cortical dysplasia type 2: Insights from sleep recordings in presurgical evaluation.

Clin Neurophysiol 2020 Mar 12;131(3):609-615. Epub 2019 Dec 12.

GHU Paris Sainte-Anne, Epilepsy Unit, Department of Neurosurgery, Paris, France. Electronic address:

Objective: To determine the relationship between seizure onset, sleep stage and focal cortical dysplasia type 2 (FCD2) location in sleep related epilepsy (SRE).

Methods: We reviewed scalp video-EEG data of 77 patients with SRE among 130 surgically treated patients with histologically confirmed FCD2. Seizure onset was classified as occurring during NREM, REM and after arousal. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.11.055DOI Listing

Neuroimaging of memory in frontal lobe epilepsy.

Epilepsy Behav 2020 02 11;103(Pt A):106857. Epub 2020 Jan 11.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.

In a large percentage of epilepsies, seizures have focal onset. These epilepsies are associated with a wide range of behavioral and cognitive deficits sometimes limited to the functions encompassed within the ictal onset zone but, more frequently, expanding beyond it. The presence of impairments associated with neuroanatomical areas outside of the ictal onset zone suggests distal propagation of epileptic activity via brain networks and interconnected whole-brain neural circuitry. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106857DOI Listing
February 2020

The white matter connectome as an individualized biomarker of language impairment in temporal lobe epilepsy.

Neuroimage Clin 2020 13;25:102125. Epub 2019 Dec 13.

Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA. Electronic address:

Objective: The distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment. Here we determine the predictive ability of the structural connectome (SC), compared with global measures of white matter tract microstructure and clinical data, to discriminate language impaired patients with temporal lobe epilepsy (TLE) from TLE patients without language impairment.

Methods: T1- and diffusion-MRI, clinical variables (CVs), and neuropsychological measures of naming and verbal fluency were available for 82 TLE patients. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.102125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953962PMC
December 2019

Assessing various sensorimotor and cognitive functions in people with epilepsy is feasible with robotics.

Epilepsy Behav 2020 02 7;103(Pt A):106859. Epub 2020 Jan 7.

Centre for Neuroscience Studies, Botterell Hall, 18 Stuart Street, Queen's University, Kingston, ON K7L 3N6, Canada; Department of Medicine, Division of Neurology, Etherington Hall, 94 Stuart Street, Queen's University, Kingston, ON K7L 3N6, Canada; Kingston Health Sciences Centre, 76 Stuart St, Kingston, ON K7L 2V7, Canada. Electronic address:

Background: Epilepsy is a common neurological disorder characterized by recurrent seizures, along with comorbid cognitive and psychosocial impairment. Current gold standards of assessment can quantify cognitive and motor performance, but may not capture all subtleties of behavior. Here, we study the feasibility of assessing various upper limb sensorimotor and cognition functions in people with epilepsy using the Kinarm robotic assessment system. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106859DOI Listing
February 2020

Longitudinal assessment of resting-state fMRI in temporal lobe epilepsy: A two-year follow-up study.

Epilepsy Behav 2020 02 31;103(Pt A):106858. Epub 2019 Dec 31.

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. Electronic address:

In this study, we aimed to detect longitudinal alterations in local spontaneous brain activity and functional connectivity (FC) of the default mode network (DMN) in patients with temporal lobe epilepsy (TLE) over a two-year follow-up. We used amplitude of low-frequency fluctuation (ALFF) analysis and independent component analysis (ICA) to explore differences in local spontaneous brain activity and FC strength. In total, 33 participants (16 patients with TLE and 17 age- and gender-matched healthy controls (HCs)) were recruited in this study. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106858DOI Listing
February 2020

Lesion-Specific Language Network Alterations in Temporal Lobe Epilepsy.

AJNR Am J Neuroradiol 2020 01 2;41(1):147-154. Epub 2020 Jan 2.

From the Departments of Biomedical Imaging and Image-Guided Therapy (O.F., K.-H.N., M.S., V.S., G.L., D.P., G.K.)

Background And Purpose: Temporal lobe epilepsy, structural or nonlesional, may negatively affect language function. However, little is known about the lesion-specific influence on language networks. We hypothesized that different epileptogenic lesions are related to distinct alterations in the functional language connectome detected by fMRI. Read More

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http://dx.doi.org/10.3174/ajnr.A6350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975318PMC
January 2020

Internalizing symptoms in intractable pediatric epilepsy: Structural and functional brain correlates.

Epilepsy Behav 2020 02 24;103(Pt A):106845. Epub 2019 Dec 24.

Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States of America; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, United States of America.

Internalizing disorders (i.e., depression and anxiety) are common comorbidities in people with epilepsy. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106845DOI Listing
February 2020

Epilepsy with migrating focal seizures: KCNT1 mutation hotspots and phenotype variability.

Neurol Genet 2019 Dec 25;5(6):e363. Epub 2019 Oct 25.

Service de Génétique (G.B., J.-P.B., S.G.-L.), Groupe Hospitalier Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1163 (G.B., N.B-.B., R.N.), Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France; Service de Neurologie Pédiatrique (N.C., N.B-.B., A.K., R.N.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Centre de Référence des Epilepsies Rares (N.C., A.K., R.N.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1129 (N.N., A.K., R.N.), Paris, France; Service de Neurophysiologie Clinique et Pédiatrie (M.K.), INSERM U1099, Hôpital Universitaire de Rennes, Université de Rennes, France; Service de Neurophysiologie Clinique (M.E., A.K.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Génétique Clinique (V.C.), Hôpital Femme Mère Enfant, Metz-Thionville, France; Pediatric Neurology Research Group (A.M.), Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain; Service de Génétique Clinique (L.L.), Hôpital d'Enfants, CHU de Nancy, Vandoeuvre-Lès-Nancy, France; Service de Pédiatrie (F.D.), CHU de Grenoble, France; Service de Neurologie Pédiatrique (D.D., T.B.V.), Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Neurologie Pédiatrique (N.V., M.M.), APHM, Hôpital d'Enfants de La Timone, Marseille, France; Service de Neurologie Pédiatrique (M-.A.B., M.M.), Centre Hospitalier Universitaire de Tours, Tours, France; Département de Génétique (C.N., M.M.), Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France; Service de Radiologie Pédiatrique (N.B., M.M.), Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Aix-Marseille (M.M.), INSERM, MMG, UMR-S 1251, Faculté de Médecine, Marseille, France; and Unité de Neurologie Pédiatrique (S.A.), Hôpital Rober Debré, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To report new sporadic cases and 1 family with epilepsy of infancy with migrating focal seizures (EIMFSs) due to KCNT1 gain-of-function and to assess therapies' efficacy including quinidine.

Methods: We reviewed the clinical, EEG, and molecular data of 17 new patients with EIMFS and mutations, in collaboration with the network of the French reference center for rare epilepsies.

Results: The mean seizure onset age was 1 month (range: 1 hour to 4 months), and all children had focal motor seizures with autonomic signs and migrating ictal pattern on EEG. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878841PMC
December 2019