4,205 results match your criteria Frontal Lobe Epilepsy


Abnormal visual sensitivity in eyelid myoclonia with absences: Evidence from electrocortical connectivity and non-linear quantitative analysis of EEG signal.

Seizure 2019 Apr 10;69:118-124. Epub 2019 Apr 10.

Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Via S. Sofia 78, 95123 Catania, Italy. Electronic address:

Purpose: Eyelid myoclonia with absences (EMA) is an epileptic syndrome characterized by eyelid myoclonia with or without absences, eyes closure-induced EEG paroxysms and photosensitivity. Pathophysiological mechanisms of visual sensitivity in EMA are not-fully understood. The objective of the present study was to analyze the electrophysiological dynamics implicated in the visual sensitivity in patients with EMA. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.04.007DOI Listing

Semiology of hyperkinetic seizures of frontal versus temporal lobe origin.

Epileptic Disord 2019 Apr;21(2):154-165

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Urushiyama, Aoi-ku, Shizuoka.

Hyperkinetic seizures are usually associated with frontal lobe epilepsy. However, some patients have hyperkinetic seizures of temporal lobe origin. The semiological differences in hyperkinetic seizures between frontal and temporal lobe epilepsy have not been well studied. Read More

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http://dx.doi.org/10.1684/epd.2019.1047DOI Listing

Similar and Differing Distributions Between F-FDG-PET and Arterial Spin Labeling Imaging in Temporal Lobe Epilepsy.

Front Neurol 2019 3;10:318. Epub 2019 Apr 3.

Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.

Despite the increasing use of arterial spin labeling (ASL) in patients with epilepsy, little is known about its brain regional distribution pattern, including diaschisis, and its correspondence with FDG-PET. Here, we investigated the regional match and mismatch between FDG-PET and ASL in temporal lobe epilepsy (TLE). We recruited 27 patients with unilateral TLE, who underwent inter-ictal ASL and FDG-PET scans. Read More

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http://dx.doi.org/10.3389/fneur.2019.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456651PMC

Emotional asymmetries in refractory medial temporal and frontal lobe epilepsy: Their impact on predicting lateralization and localization of seizures.

Epilepsy Behav 2019 Apr 10;94:269-276. Epub 2019 Apr 10.

Department of Neurosurgery, Epilepsy Surgery Unit, School of Medicine, Evangelismos Hospital, University of Athens, Greece.

Background: Emotional disturbances have been reported in patients with epilepsy. Although conflicting results emanate from relevant studies, depressive symptoms are seen more often in temporal lobe epilepsy (TLE) whereas, hypomanic/manic symptoms usually accompany frontal lobe epilepsy (FLE); the above psychiatric symptoms are especially seen in refractory epilepsy. However, neocortical TLE and medial TLE are considered as distinct epileptic syndromes, and there is limited literature on comparison of affective traits in medial TLE (MTLE) and FLE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.008DOI Listing
April 2019
1 Read

Angiocentric glioma mimicking encephalomalacia.

Radiol Case Rep 2019 Jun 28;14(6):700-703. Epub 2019 Mar 28.

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA.

Angiocentric glioma is a rare low-grade neoplasm of the central nervous system which typically presents with medication-refractory seizures in children and young adults. On magnetic resonance imaging, angiocentric glioma is classically T1 hypointense and T2/FLAIR hyperintense. We present the case of a 40-year-old male who had been followed by our institution for 17 years for management of epilepsy. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441711PMC
June 2019
1 Read

Localization value of ictal turning prone.

Seizure 2018 Dec 7;69:57-60. Epub 2018 Dec 7.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Purpose: Ictal semiology complements ictal EEG in identifying the likely epileptogenic zone. Ictal turning prone (ITP) with body turning of 90 ° or more can be seen with frontal lobe epilepsies. The aim of our study was to evaluate the localizing value of ITP in a general population of patients undergoing long term video-EEG monitoring. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.11.003DOI Listing
December 2018
1 Read

Autopsied case with MERRF/MELAS overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus.

Neuropathology 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

We present an autopsied case with A8344G-mutated myoclonus epilepsy with ragged red fibers (MERRF)/mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus. A 16-year-old Japanese woman suddenly experienced repetitive consciousness disturbances with increased serum lactate and creatine kinase levels. Magnetic resonance imaging showed abnormal intensity of bilateral precentral gyrus. Read More

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http://dx.doi.org/10.1111/neup.12551DOI Listing
April 2019
1 Read

Reflex seizure triggering: Learning about seizure producing systems.

Seizure 2019 Mar 28;69:25-30. Epub 2019 Mar 28.

National Institute of Clinical Neurosciences, Budapest, Hungary.

Aim: We aim to study the mechanism of reflex seizure triggering in close link with the system-epilepsy concept.

Method: We use data and theories presented in the literature and scrutinize a few illustrative cases.

Conclusions: The prerequisite of seizure triggering is an epilepsy-prone brain network. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.019DOI Listing

Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.

Cortex 2019 Mar 5;117:41-52. Epub 2019 Mar 5.

Neurology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Cognitive slowing is a known but comparatively under-investigated neuropsychological complication of the epilepsies in relation to other known cognitive comorbidities such as memory, executive function and language. Here we focus on a novel metric of processing speed, characterize its relative salience compared to other cognitive difficulties in epilepsy, and explore its underlying neurobiological correlates. Research participants included 55 patients with temporal lobe epilepsy (TLE) and 58 healthy controls from the Epilepsy Connectome Project (ECP) who were administered a battery of tests yielding 14 neuropsychological measures, including selected tests from the NIH Toolbox-Cognitive Battery, and underwent 3T MRI and resting state fMRI. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.02.022DOI Listing
March 2019
1 Read

Alzheimer's Disease Including Focal Presentations.

Semin Neurol 2019 Apr 29;39(2):213-226. Epub 2019 Mar 29.

Department of Neurology, Institute of Memory and Alzheimer's Disease, Assistance Publique - Hopitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Read More

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http://dx.doi.org/10.1055/s-0039-1681041DOI Listing
April 2019
2 Reads

The neuropsychological profile of parietal and occipital lobe epilepsy.

Epilepsy Behav 2019 Mar 22;94:137-143. Epub 2019 Mar 22.

Epilepsy Surgery Unit, Department of Neurosurgery, School of Medicine, Evangelismos Hospital, University of Athens, Greece.

Despite the extensive body of research in clinical neurology on the functional organization of posterior cortices, parietal and occipital lobe epilepsy (PLE and OLE) have not as yet received the attention afforded frontal and temporal lobe epilepsy (FLE and TLE), perhaps due to their low prevalence. Posterior epilepsies however, represent a challenge for epileptology in general and neuropsychological differential diagnosis in particular. Our main purpose was to examine the likely existence of a pattern of cognitive dysfunction characterizing patients suffering from seizures with a parietal and/or occipital ictal onset. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.021DOI Listing
March 2019
2 Reads

Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery.

Epilepsy Res 2019 05 19;152:59-66. Epub 2019 Mar 19.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom; The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address:

Objective: Predictors of psychiatric outcome following TLE surgery have proved elusive and represent a current challenge in the practice of TLE surgery. This prospective study investigated whether frontal lobe dysfunction is predictive of poorer psychiatric outcomes.

Methods: Forty-nine unilateral TLE surgical patients were assessed using the Beck Depression Inventory-Fast Screen (BDI-FS) and Beck Anxiety Inventory (BAI) preoperatively and 6 and 12 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.003DOI Listing

BOLD-fMRI activity informed by network variation of scalp EEG in juvenile myoclonic epilepsy.

Neuroimage Clin 2019 Mar 12;22:101759. Epub 2019 Mar 12.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 610054, China. Electronic address:

Epilepsy is marked by hypersynchronous bursts of neuronal activity, and seizures can propagate variably to any and all areas, leading to brain network dynamic organization. However, the relationship between the network characteristics of scalp EEG and blood oxygenation level-dependent (BOLD) responses in epilepsy patients is still not well known. In this study, simultaneous EEG and fMRI data were acquired in 18 juvenile myoclonic epilepsy (JME) patients. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425117PMC
March 2019
1 Read

Short-lasting retroorbital pain attacks as a form of ictal epileptic headache: Case report.

Cephalalgia 2019 Mar 16:333102419839792. Epub 2019 Mar 16.

1 Department of Clinical Neurophysiology, King's College Hospital, London, UK.

Background And Objectives: Ictal epileptic headache is a rare form of painful seizure, habitually consisting of migrainous or tension-type headache. We describe a case of a patient with short-lasting, severe retroorbital pain attacks caused by frontal lobe epilepsy.

Case Report: A 25-year-old male patient presented with recurrent attacks of paroxysmal, short-lasting, excruciating left periorbital and facial pain mainly occurring from sleep. Read More

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http://dx.doi.org/10.1177/0333102419839792DOI Listing
March 2019
1 Read

Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases.

Epilepsia 2019 Apr 13;60(4):707-717. Epub 2019 Mar 13.

Department of Neurosciences, Center for Epilepsy Surgery "C. Munari,", Hospital Niguarda, Milan, Italy.

Objectives: Sleep-related hypermotor epilepsy (SHE), formerly nocturnal frontal lobe epilepsy, is characterized by abrupt and typically sleep-related seizures with motor patterns of variable complexity and duration. They seizures arise more frequently in the frontal lobe than in the extrafrontal regions but identifying the seizure onset-zone (SOZ) may be challenging. In this study, we aimed to describe the clinical features of both frontal and extrafrontal SHE, focusing on ictal semiologic patterns in order to increase diagnostic accuracy. Read More

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http://doi.wiley.com/10.1111/epi.14690
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http://dx.doi.org/10.1111/epi.14690DOI Listing
April 2019
11 Reads

Lateralized periodic discharges in insular status epilepticus: A case report of a periodic EEG pattern associated with ictal manifestation.

Clin Neurophysiol Pract 2019 24;4:27-29. Epub 2019 Jan 24.

Department of Neurology, SS Annunziata Hospital, Chieti, Italy.

Objective: Insular lobe seizures generally represent a misconceived ictal phenomenon characterized by specific neurological signs. Aphasia can be a rare presenting sign associated with insular lobe epilepsy which could be easily mistaken for a manifestation of other acute brain diseases.

Method: We describe an insular status epilepticus (SE) characterized by sudden onset of language disturbance associated with hypersalivation and paraesthesia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2467981X193000
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http://dx.doi.org/10.1016/j.cnp.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395825PMC
January 2019
9 Reads

Perampanel-induced, new-onset food aversion in a 29-year-old female with medically refractory frontal lobe epilepsy.

Ment Health Clin 2019 Mar 1;9(2):100-104. Epub 2019 Mar 1.

Background: Perampanel is a selective, noncompetitive amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist indicated for management of partial-onset and primary generalized seizures in epilepsy patients aged ≥12 years.

Patient History: A 29-year-old, white female with significant history of medically refractory frontal lobe epilepsy, status post right frontal and temporal resections, was initiated on perampanel as an add-on therapy to phenytoin extended-release (330 mg/d) and clonazepam (2.5 mg/d). Read More

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http://mhc.cpnp.org/doi/10.9740/mhc.2019.03.100
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http://dx.doi.org/10.9740/mhc.2019.03.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398359PMC
March 2019
4 Reads

A late onset adult seizure due to intracerebral needle: case-based update.

Childs Nerv Syst 2019 Apr 27;35(4):593-600. Epub 2019 Feb 27.

Department of Neurosurgery, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.

Background And Aim: Late-onset seizure due to intracerebral needle is a rare entity. Most of them were clinically asymptomatic and rarely presented with seizure. Sewing needles are used in homicidal attempt in infancy or early childhood before the closure of the fontanels. Read More

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http://link.springer.com/10.1007/s00381-019-04095-2
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http://dx.doi.org/10.1007/s00381-019-04095-2DOI Listing
April 2019
10 Reads

and Nocturnal Frontal Lobe Epilepsy: Identification and Characterization of a Novel Loss of Function Mutation.

Front Mol Neurosci 2019 12;12:17. Epub 2019 Feb 12.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

Mutations in genes coding for subunits of the neuronal nicotinic acetylcholine receptor (nAChR) have been involved in familial sleep-related hypermotor epilepsy (also named autosomal dominant nocturnal frontal lobe epilepsy, ADNFLE). Most of these mutations reside in and genes, coding for the α4 and β2 nAChR subunits, respectively. Two mutations with contrasting functional effects were also identified in the gene coding for the α2 subunit. Read More

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http://dx.doi.org/10.3389/fnmol.2019.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379349PMC
February 2019
1 Read
3.902 Impact Factor

Reassessing the impact of intraoperative electrocorticography on postoperative outcome of patients undergoing standard temporal lobectomy for MRI-negative temporal lobe epilepsy.

J Neurosurg 2019 Feb 22:1-10. Epub 2019 Feb 22.

Departments of2Neurologic Surgery.

OBJECTIVEAlmost 30% of the patients with suspected temporal lobe epilepsy (TLE) have normal results on MRI. Success rates for resection of MRI-negative TLE are less favorable, ranging from 36% to 76%. Herein the authors describe the impact of intraoperative electrocorticography (ECoG) augmented by opioid activation and its effect on postoperative seizure outcome. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182124DOI Listing
February 2019
3 Reads

The temporoinsular projection system: an anatomical study.

J Neurosurg 2019 Feb 22:1-9. Epub 2019 Feb 22.

1Department of Neurosciences, Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, and.

OBJECTIVEConnections between the insular cortex and the amygdaloid complex have been demonstrated using various techniques. Although functionally well connected, the precise anatomical substrate through which the amygdaloid complex and the insula are wired remains unknown. In 1960, Klingler briefly described the "fasciculus amygdaloinsularis," a white matter tract connecting the posterior insula with the amygdala. Read More

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http://dx.doi.org/10.3171/2018.11.JNS18679DOI Listing
February 2019

Seizures and movement disorders: phenomenology, diagnostic challenges and therapeutic approaches.

J Neurol Neurosurg Psychiatry 2019 Feb 22. Epub 2019 Feb 22.

Neurology, Krembil Brain Institute; Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto, Ontario, Canada

Seizures and movement disorders (MDs) are distinct neurological conditions presenting with abnormal movements. Despite sharing an overlap in phenomenology, these movements have different origins. In order to explore the overlaps and the narrow boundaries between these two conditions, we performed a review of the literature to explore the risk of seizures in MDs. Read More

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http://dx.doi.org/10.1136/jnnp-2018-320039DOI Listing
February 2019
2 Reads

Cerebral granuloma mimicking malignant neoplasm in a patient with seizures 21 years after head trauma.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, The Affliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China. Electronic address:

Background: Chronic post-traumatic cerebral granuloma is a rare, delayed complication of traumatic brain injury. Because of its late onset of symptoms and atypical appearance, the correct diagnosis of this rare lesion is difficult.

Case Report: A 49-year-old man presented with seizures, which occured 21 years after open right forehead trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193040
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http://dx.doi.org/10.1016/j.wneu.2019.01.286DOI Listing
February 2019
3 Reads

The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Wakefulness and sleep arise from global changes in brain physiology that may also govern the flow of neural activity between cortical regions responsible for perceptual processing vs planning and action. To test whether and how the sleep/wake cycle affects the overall propagation of neural activity in large-scale brain networks, we applied single-pulse electrical stimulation (SPES) in patients implanted with intracranial EEG electrodes for epilepsy surgery. SPES elicited cortico-cortical spectral responses at high-gamma frequencies (CCSRHG, 80-150 Hz), which indexes changes in neuronal population firing rates. Read More

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http://dx.doi.org/10.1093/sleep/zsz050DOI Listing
February 2019
1 Read
4.591 Impact Factor

Emerging role of prodromal headache in patients with anti-N-methyl-D-aspartate receptor encephalitis.

J Pain Res 2019 30;12:519-526. Epub 2019 Jan 30.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China Email

Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis patients often present with psychiatric symptoms, cognitive dysfunction, epilepsy and memory deficits. A previous study has suggested that headache can occurr during the early stages of anti-NMDAR encephalitis. However, the exact association between headache and anti-NMDAR encephalitis has hardly been investigated, apart from a few case studies. Read More

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http://dx.doi.org/10.2147/JPR.S189301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365221PMC
January 2019
2 Reads

Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 12.

Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, 1202 Geneva, Switzerland.

Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. Read More

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http://dx.doi.org/10.1523/ENEURO.0494-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378326PMC
April 2019
4 Reads

Epilepsy surgery in the first months of life: a large type IIb focal cortical dysplasia causing neonatal drug-resistant epilepsy.

Epileptic Disord 2019 Feb;21(1):122-127

Department of Neurosurgery, Section for Pediatric Neurosurgery, University of Ulm, Germany.

Focal cortical dysplasia is a common cause of medically refractory epilepsy in infancy and childhood. We report a neonate with seizures occurring within the first day of life. Continuous video-EEG monitoring led to detection of left motor seizures and a right frontal EEG seizure pattern. Read More

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http://dx.doi.org/10.1684/epd.2019.1037DOI Listing
February 2019
2 Reads

DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb;21(1):42-47

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019
1 Read

The Analysis of Risk Factors and Survival Outcome for Chinese Patients with Epilepsy with High-Grade Glioma.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: To evaluate the risk factors of tumor-related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in patients with high-grade glioma (HGG).

Methods: The clinical data of 587 patients with HGG were retrospectively analyzed. A χ test and logistic multiple-regression analysis were used to analyze factors associated with TRE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193032
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http://dx.doi.org/10.1016/j.wneu.2019.01.213DOI Listing
February 2019
14 Reads

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 May 12;40(5):993-1000. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
May 2019
1 Read

fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.

Epilepsia 2019 Mar 11;60(3):527-538. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method: Thirty-five adults (mean age 37. Read More

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http://dx.doi.org/10.1111/epi.14656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401285PMC
March 2019
5 Reads

Machine learning identifies "rsfMRI epilepsy networks" in temporal lobe epilepsy.

Eur Radiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Electrical Engineering, Indian Institute of Technology Delhi, (IIT-D), New Delhi, Delhi, 110016, India.

Objectives: Experimental models have provided compelling evidence for the existence of neural networks in temporal lobe epilepsy (TLE). To identify and validate the possible existence of resting-state "epilepsy networks," we used machine learning methods on resting-state functional magnetic resonance imaging (rsfMRI) data from 42 individuals with TLE.

Methods: Probabilistic independent component analysis (PICA) was applied to rsfMRI data from 132 subjects (42 TLE patients + 90 healthy controls) and 88 independent components (ICs) were obtained following standard procedures. Read More

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http://link.springer.com/10.1007/s00330-019-5997-2
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http://dx.doi.org/10.1007/s00330-019-5997-2DOI Listing
February 2019
22 Reads
4.014 Impact Factor

Clinical and electroencephalographic correlates of psychiatric features in children with frontal lobe epilepsy.

Epilepsy Behav 2019 Mar 4;92:283-289. Epub 2019 Feb 4.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy. Electronic address:

Background And Objective: Frontal lobe epilepsy (FLE) is often associated with psychiatric features, although the factors predisposing to the concurrence of these conditions have yet to be determined, especially in younger children. We aimed at defining possible clinical and electroencephalography (EEG) features that may enhance the psychiatric risk in pediatric FLE.

Method: We performed a structured psychiatric assessment of 59 children with FLE, using both categorical and dimensional approaches, correlated psychopathology with epilepsy data, and cognitive development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2019.01.008DOI Listing
March 2019
8 Reads

Ictal asystole with isolated syncope: A case report and literature review.

Epilepsy Behav Case Rep 2019 24;11:47-51. Epub 2018 Nov 24.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-8435, USA.

Ictal syncope is a rare phenomenon that occurs in association with 0.002-0.4% of seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183014
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http://dx.doi.org/10.1016/j.ebcr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327908PMC
November 2018
12 Reads

Hemispheric Regional Based Analysis of Diffusion Tensor Imaging and Diffusion Tensor Tractography in Patients with Temporal Lobe Epilepsy and Correlation with Patient outcomes.

Sci Rep 2019 Jan 18;9(1):215. Epub 2019 Jan 18.

Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.

Imaging in the field of epilepsy surgery remains an essential tool in terms of its ability to identify regions where the seizure focus might present as a resectable area. However, in many instances, an obvious structural abnormality is not visualized. This has created the opportunity for new approaches and imaging innovation in the field of epilepsy, such as with Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT). Read More

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http://www.nature.com/articles/s41598-018-36818-x
Publisher Site
http://dx.doi.org/10.1038/s41598-018-36818-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338779PMC
January 2019
11 Reads

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods.

Epilepsy Behav Case Rep 2019 1;11:39-42. Epub 2018 Nov 1.

Brno Epilepsy Centre, Department of Paediatric Neurology, University Hospital, Masaryk University, Brno, Czech Republic.

Purpose: Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313257PMC
November 2018
17 Reads

Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography.

Epilepsy Behav Case Rep 2019 12;11:10-13. Epub 2018 Oct 12.

Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

•A drug-resistant epilepsy case showed hypermotor seizures and amygdala enlargement.•Seizure onset zone was the hippocampus, not amygdala, as revealed by SEEG.•The enlarged amygdala pathology was classified as FCD type I. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305660PMC
October 2018

Localization yield and seizure outcome in patients undergoing bilateral SEEG exploration.

Epilepsia 2019 Jan 26;60(1):107-120. Epub 2018 Dec 26.

Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: We aimed to determine the rates and predictors of resection and seizure freedom after bilateral stereo-electroencephalography (SEEG) implantation.

Methods: We reviewed 184 patients who underwent bilateral SEEG implantation (2009-2015). Noninvasive and invasive evaluation findings were collected. Read More

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http://doi.wiley.com/10.1111/epi.14624
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http://dx.doi.org/10.1111/epi.14624DOI Listing
January 2019
27 Reads

Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy.

Epilepsy Behav 2019 Jan 18;90:162-167. Epub 2018 Dec 18.

Bakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Neurology Department, Bakirkoy, 34147 Istanbul, Turkey.

Objectives: Mesial temporal lobe epilepsy (MTLE) is the most common form of partial epilepsies. Seizures of MTLE with hippocampal sclerosis (MTLE-HS) are typically resistant to antiepileptic drug (AED) therapy. Although memory disturbances in patients with MTLE-HS are expected, verbal attention and frontal lobe functions may also be impaired. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.034DOI Listing
January 2019
5 Reads

The Influence of Anesthesia on Corticocortical Evoked Potential Monitoring Network Between Frontal and Temporoparietal Cortices.

World Neurosurg 2019 Mar 18;123:e685-e692. Epub 2018 Dec 18.

Department of Neurosurgery, Sapporo Medical University, Sapporo, Hokkaido, Japan. Electronic address:

Background: Previous studies have reported the usefulness of intraoperative corticocortical evoked potentials (CCEPs) for preserving language function during brain surgery.

Objective: This study aimed to assess the influence of depth of anesthesia on CCEP to establish its clinical utility.

Methods: Twenty patients with brain tumors or epilepsy who underwent awake craniotomy were included in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183282
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http://dx.doi.org/10.1016/j.wneu.2018.11.253DOI Listing
March 2019
20 Reads

Nicotine increases sleep spindle activity.

J Sleep Res 2018 Dec 18:e12800. Epub 2018 Dec 18.

Department of Neurology, Geneva University Hospital, Geneva, Switzerland.

Studies have shown that both nicotine and sleep spindles are associated with enhanced memorisation. Further, a few recent studies have shown how cholinergic input through nicotinic and muscarinic receptors can trigger or modulate sleep processes in general, and sleep spindles in particular. To better understand the interaction between nicotine and sleep spindles, we compared in a single blind randomised study the characteristics of sleep spindles in 10 healthy participants recorded for 2 nights, one with a nicotine patch and one with a sham patch. Read More

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http://dx.doi.org/10.1111/jsr.12800DOI Listing
December 2018
2 Reads

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.

Hawaii J Med Public Health 2018 Dec;77(12):319-324

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (NLB,JCK,AS).

Gelastic seizures (GS) are a rare form of epilepsy characterized by inappropriate, uncontrolled laughter. They are highly associated with abnormal cognitive development and behavioral problems in patients. Research has shown that GS can originate from hypothalamic hamartomas (HH), non- neoplastic masses consisting of gray matter with large and small neurons interspersed with glial nuclei. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277842PMC
December 2018
3 Reads

Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti-LGI1 encephalitis: a video-polygraphic study.

Epileptic Disord 2018 Dec;20(6):525-529

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

The origin of faciobrachial dystonic seizures in anti-LGI1 encephalitis is controversial due to a lack of neurophysiological characterization. We report a 68-year-old man with subacute anterograde memory loss and involuntary faciobrachial movements. Video-polygraphic recordings disclosed repetitive events characterized by sudden, short contraction of the upper limbs and ipsilateral hemiface. Read More

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http://dx.doi.org/10.1684/epd.2018.1010DOI Listing
December 2018
2 Reads
0.899 Impact Factor

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec;20(6):490-501

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1014DOI Listing
December 2018
2 Reads

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec;20(6):457-467

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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http://dx.doi.org/10.1684/epd.2018.1009DOI Listing
December 2018
8 Reads

Psychosocial complications in juvenile myoclonic epilepsy.

Epilepsy Behav 2019 Jan 22;90:122-128. Epub 2019 Jan 22.

Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.022DOI Listing
January 2019
15 Reads

Age-dependent semiology of frontal lobe seizures.

Epilepsy Res 2019 01 23;149:83-87. Epub 2018 Oct 23.

Epilepsy Center, University Medical Center, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Introduction: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far.

Material And Methods: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183040
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.007DOI Listing
January 2019
28 Reads

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2019 Jan 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183074
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http://dx.doi.org/10.1016/j.yebeh.2018.10.033DOI Listing
January 2019
23 Reads
2.257 Impact Factor

Prediction error connectivity: A new method for EEG state analysis.

Neuroimage 2019 Mar 1;188:261-273. Epub 2018 Dec 1.

Epilepsy Unit - Neurology Dept. Hospital del Mar - Parc de Salut Mar, Barcelona, Spain; IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain.

Several models have been proposed to explain brain regional and interregional communication, the majority of them using methods that tap the frequency domain, like spectral coherence. Considering brain interareal communication as binary interactions, we describe a novel method devised to predict dynamics and thus highlight abrupt changes marked by unpredictability. Based on a variable-order Markov model algorithm developed in-house for data compression, the prediction error connectivity (PEC) estimates network transitions by calculating error matrices (EMs). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.11.052DOI Listing
March 2019
3 Reads