4,171 results match your criteria Frontal Lobe Epilepsy


DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019

The analysis of risk factors and survival outcome for Chinese high-grade glioma patients with epilepsy.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Objective: To evaluate the risk factors of tumor related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in high-grade glioma (HGG) patients.

Method: The clinical data of 587 patients with HGG were retrospectively analyzed. Chi-square test and logistic multiple regression analysis were used to analyze factors associated with TRE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193032
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http://dx.doi.org/10.1016/j.wneu.2019.01.213DOI Listing
February 2019
3 Reads

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
February 2019

fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method: Thirty-five adults (mean age 37. Read More

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http://dx.doi.org/10.1111/epi.14656DOI Listing
February 2019

Machine learning identifies "rsfMRI epilepsy networks" in temporal lobe epilepsy.

Eur Radiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Electrical Engineering, Indian Institute of Technology Delhi, (IIT-D), New Delhi, Delhi, 110016, India.

Objectives: Experimental models have provided compelling evidence for the existence of neural networks in temporal lobe epilepsy (TLE). To identify and validate the possible existence of resting-state "epilepsy networks," we used machine learning methods on resting-state functional magnetic resonance imaging (rsfMRI) data from 42 individuals with TLE.

Methods: Probabilistic independent component analysis (PICA) was applied to rsfMRI data from 132 subjects (42 TLE patients + 90 healthy controls) and 88 independent components (ICs) were obtained following standard procedures. Read More

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http://link.springer.com/10.1007/s00330-019-5997-2
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http://dx.doi.org/10.1007/s00330-019-5997-2DOI Listing
February 2019
8 Reads

Clinical and electroencephalographic correlates of psychiatric features in children with frontal lobe epilepsy.

Epilepsy Behav 2019 Feb 4;92:283-289. Epub 2019 Feb 4.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy. Electronic address:

Background And Objective: Frontal lobe epilepsy (FLE) is often associated with psychiatric features, although the factors predisposing to the concurrence of these conditions have yet to be determined, especially in younger children. We aimed at defining possible clinical and electroencephalography (EEG) features that may enhance the psychiatric risk in pediatric FLE.

Method: We performed a structured psychiatric assessment of 59 children with FLE, using both categorical and dimensional approaches, correlated psychopathology with epilepsy data, and cognitive development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2019.01.008DOI Listing
February 2019
3 Reads

Ictal asystole with isolated syncope: A case report and literature review.

Epilepsy Behav Case Rep 2019 24;11:47-51. Epub 2018 Nov 24.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-8435, USA.

Ictal syncope is a rare phenomenon that occurs in association with 0.002-0.4% of seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183014
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http://dx.doi.org/10.1016/j.ebcr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327908PMC
November 2018
5 Reads

Hemispheric Regional Based Analysis of Diffusion Tensor Imaging and Diffusion Tensor Tractography in Patients with Temporal Lobe Epilepsy and Correlation with Patient outcomes.

Sci Rep 2019 Jan 18;9(1):215. Epub 2019 Jan 18.

Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA, USA.

Imaging in the field of epilepsy surgery remains an essential tool in terms of its ability to identify regions where the seizure focus might present as a resectable area. However, in many instances, an obvious structural abnormality is not visualized. This has created the opportunity for new approaches and imaging innovation in the field of epilepsy, such as with Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT). Read More

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http://www.nature.com/articles/s41598-018-36818-x
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http://dx.doi.org/10.1038/s41598-018-36818-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338779PMC
January 2019
7 Reads

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods.

Epilepsy Behav Case Rep 2019 1;11:39-42. Epub 2018 Nov 1.

Brno Epilepsy Centre, Department of Paediatric Neurology, University Hospital, Masaryk University, Brno, Czech Republic.

Purpose: Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313257PMC
November 2018
12 Reads

Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography.

Epilepsy Behav Case Rep 2019 12;11:10-13. Epub 2018 Oct 12.

Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.

•A drug-resistant epilepsy case showed hypermotor seizures and amygdala enlargement.•Seizure onset zone was the hippocampus, not amygdala, as revealed by SEEG.•The enlarged amygdala pathology was classified as FCD type I. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305660PMC
October 2018

Localization yield and seizure outcome in patients undergoing bilateral SEEG exploration.

Epilepsia 2019 Jan 26;60(1):107-120. Epub 2018 Dec 26.

Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: We aimed to determine the rates and predictors of resection and seizure freedom after bilateral stereo-electroencephalography (SEEG) implantation.

Methods: We reviewed 184 patients who underwent bilateral SEEG implantation (2009-2015). Noninvasive and invasive evaluation findings were collected. Read More

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http://doi.wiley.com/10.1111/epi.14624
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http://dx.doi.org/10.1111/epi.14624DOI Listing
January 2019
23 Reads

Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy.

Epilepsy Behav 2019 Jan 18;90:162-167. Epub 2018 Dec 18.

Bakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, Neurology Department, Bakirkoy, 34147 Istanbul, Turkey.

Objectives: Mesial temporal lobe epilepsy (MTLE) is the most common form of partial epilepsies. Seizures of MTLE with hippocampal sclerosis (MTLE-HS) are typically resistant to antiepileptic drug (AED) therapy. Although memory disturbances in patients with MTLE-HS are expected, verbal attention and frontal lobe functions may also be impaired. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.034DOI Listing
January 2019
2 Reads

Nicotine increases sleep spindle activity.

J Sleep Res 2018 Dec 18:e12800. Epub 2018 Dec 18.

Department of Neurology, Geneva University Hospital, Geneva, Switzerland.

Studies have shown that both nicotine and sleep spindles are associated with enhanced memorisation. Further, a few recent studies have shown how cholinergic input through nicotinic and muscarinic receptors can trigger or modulate sleep processes in general, and sleep spindles in particular. To better understand the interaction between nicotine and sleep spindles, we compared in a single blind randomised study the characteristics of sleep spindles in 10 healthy participants recorded for 2 nights, one with a nicotine patch and one with a sham patch. Read More

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http://dx.doi.org/10.1111/jsr.12800DOI Listing
December 2018

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.

Hawaii J Med Public Health 2018 Dec;77(12):319-324

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (NLB,JCK,AS).

Gelastic seizures (GS) are a rare form of epilepsy characterized by inappropriate, uncontrolled laughter. They are highly associated with abnormal cognitive development and behavioral problems in patients. Research has shown that GS can originate from hypothalamic hamartomas (HH), non- neoplastic masses consisting of gray matter with large and small neurons interspersed with glial nuclei. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277842PMC
December 2018
2 Reads

Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti-LGI1 encephalitis: a video-polygraphic study.

Epileptic Disord 2018 Dec;20(6):525-529

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

The origin of faciobrachial dystonic seizures in anti-LGI1 encephalitis is controversial due to a lack of neurophysiological characterization. We report a 68-year-old man with subacute anterograde memory loss and involuntary faciobrachial movements. Video-polygraphic recordings disclosed repetitive events characterized by sudden, short contraction of the upper limbs and ipsilateral hemiface. Read More

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http://dx.doi.org/10.1684/epd.2018.1010DOI Listing
December 2018
1 Read
0.899 Impact Factor

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec;20(6):490-501

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1014DOI Listing
December 2018
2 Reads

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec;20(6):457-467

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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http://dx.doi.org/10.1684/epd.2018.1009DOI Listing
December 2018
2 Reads

Psychosocial complications in juvenile myoclonic epilepsy.

Epilepsy Behav 2019 Jan 22;90:122-128. Epub 2019 Jan 22.

Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.022DOI Listing
January 2019
10 Reads

Age-dependent semiology of frontal lobe seizures.

Epilepsy Res 2019 Jan 23;149:83-87. Epub 2018 Oct 23.

Epilepsy Center, University Medical Center, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Introduction: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far.

Material And Methods: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183040
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.007DOI Listing
January 2019
16 Reads

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2019 Jan 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183074
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http://dx.doi.org/10.1016/j.yebeh.2018.10.033DOI Listing
January 2019
13 Reads
2.257 Impact Factor

Prediction error connectivity: A new method for EEG state analysis.

Neuroimage 2018 Dec 1;188:261-273. Epub 2018 Dec 1.

Epilepsy Unit - Neurology Dept. Hospital del Mar - Parc de Salut Mar, Barcelona, Spain; IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain.

Several models have been proposed to explain brain regional and interregional communication, the majority of them using methods that tap the frequency domain, like spectral coherence. Considering brain interareal communication as binary interactions, we describe a novel method devised to predict dynamics and thus highlight abrupt changes marked by unpredictability. Based on a variable-order Markov model algorithm developed in-house for data compression, the prediction error connectivity (PEC) estimates network transitions by calculating error matrices (EMs). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.11.052DOI Listing
December 2018
2 Reads

Periventricular nodular heterotopia in 22q11.2 deletion and frontal lobe migration.

Ann Clin Transl Neurol 2018 Nov 23;5(11):1314-1322. Epub 2018 Sep 23.

Division of Neurology Department of Medicine Krembil Neuroscience Centre Toronto Western Hospital University of Toronto Toronto Ontario Canada.

Objective: We aimed to delineate the distribution of periventricular nodular heterotopia (PNH) in patients with 22q11.2 microdeletion syndrome (22q11.2DS) and place this in the context of other genetic forms of PNH. Read More

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http://doi.wiley.com/10.1002/acn3.641
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http://dx.doi.org/10.1002/acn3.641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243376PMC
November 2018
14 Reads

Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry.

Pharmacol Res 2019 Jan 22;139:215-227. Epub 2018 Nov 22.

University of Sydney, School of Pharmacy, Faculty of Medicine and Health, Building (A15) Science Road, Camperdown, NSW, 2006, Australia; Brain and Mind Centre, 94 Mallett Street, Camperdown, NSW, 2050, Australia. Electronic address:

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor. Pentameric α4β2 nACh receptors are the most abundant nicotinic receptor in the mammalian brain and form two stoichiometries, the (α4)(β2) and (α4)(β2) receptors that differ in their physiological and pharmacological properties. The purpose of this study was to investigate how ADNFLE mutations β2, β2 or α manifest themselves in different receptor stoichiometries. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.031DOI Listing
January 2019

Noise-Assisted Multivariate EMD-Based Mean-Phase Coherence Analysis to Evaluate Phase-Synchrony Dynamics in Epilepsy Patients.

IEEE Trans Neural Syst Rehabil Eng 2018 Dec 15;26(12):2270-2279. Epub 2018 Nov 15.

Spatiotemporal evolution of synchrony dynamics among neuronal populations plays an important role in decoding complicated brain function in normal cognitive processing as well as during pathological conditions such as epileptic seizures. In this paper, a non-linear analytical methodology is proposed to quantitatively evaluate the phase-synchrony dynamics in epilepsy patients. A set of finite neuronal oscillators was adaptively extracted from a multi-channel electrocorticographic (ECoG) dataset utilizing noise-assisted multivariate empirical mode de-composition (NA-MEMD). Read More

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https://ieeexplore.ieee.org/document/8536905/
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http://dx.doi.org/10.1109/TNSRE.2018.2881606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326379PMC
December 2018
9 Reads
3.188 Impact Factor

Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review.

Br J Neurosurg 2018 Nov 19:1-3. Epub 2018 Nov 19.

a Department of Neurosurgery , The First Affiliated Hospital of Zhengzhou University , ZhengZhou , HeNan Province , PR China.

Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with epilepsy. Read More

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http://dx.doi.org/10.1080/02688697.2018.1523367DOI Listing
November 2018
9 Reads

Invasive nasal histiocytic sarcoma as a cause of epilepsy .

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918811179. Epub 2018 Nov 8.

Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, Utrecht University, The Netherlands.

Case Summary: A 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity. MRI of the head revealed an expansile soft tissue mass in the caudal nasal passages (both sides but predominantly right-sided) involving the ethmoid bone and extending through the cribriform plate into the cranial vault affecting predominantly the right frontal lobe and temporal lobe. Histopathological examination of the tumour revealed a histiocytic sarcoma. Read More

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http://dx.doi.org/10.1177/2055116918811179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236490PMC
November 2018

EMD-Based, Mean-Phase Coherence Analysis to Assess Instantaneous Phase-Synchrony Dynamics in Epilepsy Patients.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2406-2409

In this paper, an adaptive, non-linear, analytical methodology is proposed in order to quantitatively evaluate the instantaneous phase-synchrony dynamics in epilepsy patients. A group of finite neuronal oscillators is extracted from a multichannel electrocorticographic (ECoG) data, using the empirical mode decomposition (EMD). The instantaneous phases of the extracted oscillators are measured using the Hilbert transform in order to be utilized in the mean-phase coherence analysis. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344039PMC

Recurrent focal seizures as a feature of status epilepticus presenting as a peri-ictal water drinking.

Epilepsy Behav Case Rep 2018 9;10:129-132. Epub 2018 Oct 9.

University Hospitals - Cleveland Medical Center, Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

We report a case of focal status epilepticus (SE) associated with peri-ictal water drinking (PIWD) behavior in a nine-year-old left-handed boy with epilepsy. We reviewed prior cases of epileptic peri-ictal water drinking. Only one adult patient with status epilepticus and PIWD has been reported previously. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216106PMC
October 2018
1 Read

The first-hour-of-the-day sleep EEG reliably identifies interictal epileptiform discharges during long-term video-EEG monitoring.

Seizure 2018 Dec 26;63:48-51. Epub 2018 Oct 26.

Department of Neurology, University of Chicago, Chicago, IL 60637, USA.

Purpose: To determine the usefulness of the first-hour sleep EEG recording in identifying interictal epileptiform discharges (IEDs) during long-term video-EEG monitoring.

Method: We retrospectively reviewed 255 consecutive patients who underwent continuous long-term video-EEG monitoring in the adult epilepsy monitoring unit (EMU) at the University of Chicago. The complete video-EEG recording was reviewed, and the occurrence of IEDs was determined for each patient. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.10.015DOI Listing
December 2018
2 Reads

Sleep architecture in adults with epilepsy: a systematic review.

Sleep Med 2019 Jan 21;53:22-27. Epub 2018 Sep 21.

Institute of Neurology, Federal University of Rio de Janeiro, Rio de Janeiro/RJ, 22290240, Brazil. Electronic address:

Objectives: To assess whether sleep architecture differs in subgroups of adults with epilepsy or in adults with epilepsy compared to control populations.

Methods: We completed a systematic review of papers published in two databases up to May 2018, with adults with epilepsy who have undergone either two consecutive nights of in-laboratory polysomnography (PSG) or one night of ambulatory PSG. Our review followed the PRISMA statements and guidelines and the protocol was registered in the PROSPERO platform prior to initiation of the review process (record CRD42018084009). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.09.004DOI Listing
January 2019
2 Reads

Investigation of paediatric occipital epilepsy using stereo-EEG reveals a better surgical outcome than in adults, especially when the supracalcarine area is affected.

Epileptic Disord 2018 Oct;20(5):346-363

Pediatric Neurosurgery, Rothschild Foundation Hospital, Paris.

Occipital epilepsy is the least common among surgical series because: (1) the location makes it hard to asses by EEG; (2) the seizure semiology often reflects propagation; and (3) surgery entails a high risk of neurological deficits. In children, subjective symptoms are harder to assess, adding to the difficulty of a proper diagnosis. We aimed to determine electroclinical characteristics of occipital lobe epilepsy in a paediatric population by reviewing 20 children between one and 16 years, who had undergone intracranial recordings with depth electrodes. Read More

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http://dx.doi.org/10.1684/epd.2018.1000DOI Listing
October 2018
22 Reads

Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation.

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0996DOI Listing
October 2018
2 Reads

Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients.

Epilepsy Res 2018 12 9;148:37-43. Epub 2018 Oct 9.

Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, Ciudad deMéxico, Mexico. Electronic address:

Neuroinflammation has been shown to constitute a crucial mechanism in the pathophysiology of epileptic brain and several genes of inflammatory mediators have been detected in surgically resected hippocampus tissue but not in non-related seizure brain regions. Interestingly, it has been reported an olfactory dysfunction in frontal lobe epilepsy (FLE). Our aim was to quantify the gene expression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs (OB) tissue from FLE patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183002
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http://dx.doi.org/10.1016/j.eplepsyres.2018.09.012DOI Listing
December 2018
11 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
9 Reads

Stimulation-induced ictal vocalisation of left frontal lobe origin.

Epileptic Disord 2018 Oct;20(5):418-422

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

Pure ictal non-speech vocalisation occurs in frontal and temporal lobe epilepsies. Electrical stimulation of supplementary motor areas is reported to evoke vocalisation in selected patients. Here, we report a patient with focal epilepsy of the left anterior insula who had isolated monotonous vocalisation elicited by electrical stimulation of the left superior frontal gyrus. Read More

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http://dx.doi.org/10.1684/epd.2018.0990DOI Listing
October 2018
11 Reads

Deviance detection is the dominant component of auditory contextual processing in the lateral superior temporal gyrus: A human ECoG study.

Hum Brain Mapp 2019 Mar 24;40(4):1184-1194. Epub 2018 Oct 24.

Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.

Auditory contextual processing has been assumed to be based on a hierarchical structure consisting of the primary auditory cortex, superior temporal gyrus (STG), and frontal lobe. Recent invasive studies on mismatch negativity (MMN) have revealed functional segregation for auditory contextual processing such as neural adaptation in the primary auditory cortex and prediction in the frontal lobe. However, the role of the STG remains unclear. Read More

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http://dx.doi.org/10.1002/hbm.24438DOI Listing

Sleep-related hypermotor epilepsy: prevalence, impact and management strategies.

Nat Sci Sleep 2018 10;10:317-326. Epub 2018 Oct 10.

"Claudio Munari" Center for Epilepsy Surgery, Niguarda Hospital, Milan, Italy,

Sleep-related hypermotor epilepsy (SHE), previously called nocturnal frontal lobe epilepsy (NFLE), is a focal epilepsy characterized by asymmetric tonic/dystonic posturing and/or complex hyperkinetic seizures occurring mostly during sleep. SHE fulfills the definition of rare disease with an estimated minimum prevalence of 1.8/100,000 individuals, and it represents about 10% of drug-resistant surgical cases. Read More

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https://www.dovepress.com/sleep-related-hypermotor-epilepsy-
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http://dx.doi.org/10.2147/NSS.S152624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186898PMC
October 2018
16 Reads

A clinical efficacy experience of Lacosamide on sleep quality in patients with Nocturnal Frontal Lobe Epilepsy (NFLE).

Acta Biomed 2018 Oct 8;89(3):397-399. Epub 2018 Oct 8.

Neurology and Neurophysiology Department of M.G. Vannini Hospital Rome.

Background: Nocturnal frontal lobe epilepsy (NFLE) is a focal epilepsy with seizures arising mainly during sleep and characterized by complex motor behavior or sustained dystonic posturing. First described in 1981, it was considered a motor disorder of sleep and was indicated as nocturnal paroxysmal dystonia (NPD). The debated on epileptic origin of this condition was demonstrated in 1990 and the term NFLE was introduced. Read More

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http://dx.doi.org/10.23750/abm.v89i3.6956DOI Listing
October 2018
1 Read

Early onset motor semiology in seizures triggered by cortical stimulation during SEEG.

Epilepsy Behav 2018 Nov 11;88:262-267. Epub 2018 Oct 11.

Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France; Service de Neurophysiologie Clinique, CHU Timone, AP-HM, Marseille, France.

Objectives: The objective of the study was to describe electroclinical patterns in habitual seizures with motor semiology at onset, triggered by diagnostic stimulation, in patients undergoing presurgical evaluation using stereoelectroencephalography (SEEG).

Methods: Seizure semiology, stimulation parameters, electroclinical data, and anatomical localization were evaluated in stimulated and spontaneous seizures.

Results: From 120 habitual seizures triggered by 50-Hz train bipolar stimulation during SEEG, 20 presented initial motor semiology (elementary motor signs, complex motor behavior, or both). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183047
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http://dx.doi.org/10.1016/j.yebeh.2018.09.017DOI Listing
November 2018
8 Reads

Theory of Mind impairment in focal versus generalized epilepsy.

Epilepsy Behav 2018 Nov 11;88:244-250. Epub 2018 Oct 11.

Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

Theory of Mind (ToM) is a critical component of social cognition, and thus, its impairment may adversely affect social functioning and quality of life. Recent evidence has suggested that it is impaired in epilepsy. What is not clear, however, is whether it is related to particular types of epilepsy or other factors. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.09.026DOI Listing
November 2018
1 Read

Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.

Eur J Nucl Med Mol Imaging 2019 02 29;46(2):385-395. Epub 2018 Sep 29.

Faculty of Medicine, Geneva University, 1211, Geneva, Switzerland.

Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.

Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. Read More

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http://link.springer.com/10.1007/s00259-018-4175-0
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http://dx.doi.org/10.1007/s00259-018-4175-0DOI Listing
February 2019
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Altered Dynamic Functional Network Connectivity in Frontal Lobe Epilepsy.

Brain Topogr 2018 Sep 25. Epub 2018 Sep 25.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, No. 4, Section 2, North Jianshe Road, Chengdu, 610054, People's Republic of China.

Frontal lobe epilepsy has recently been associated with disrupted brain functional connectivity; variations among various resting-state networks (RSNs) across time remains largely unclear. This study applied dynamic functional network connectivity (dFNC) analysis to investigate functional patterns in the temporal and spatial domains of various functional systems in FLE. Resting-state fMRI data were acquired from 19 FLE patients and 18 controls. Read More

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http://link.springer.com/10.1007/s10548-018-0678-z
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http://dx.doi.org/10.1007/s10548-018-0678-zDOI Listing
September 2018
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Application of Awake Surgery for Epilepsy in Clinical Practice.

Neurol Med Chir (Tokyo) 2018 Oct 21;58(10):442-452. Epub 2018 Sep 21.

Department of Neurosurgery, Nagoya University School of Medicine.

Epilepsy surgery aims to control epilepsy by resecting the epileptogenic region while preserving function. In some patients with epileptogenic foci in and around functionally eloquent areas, awake surgery is implemented. We analyzed the surgical outcomes of such patients and discuss the clinical application of awake surgery for epilepsy. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186762PMC
October 2018
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Evaluation of different ulegyria patterns with magnetic resonance imaging.

J Clin Neurosci 2018 Dec 21;58:148-155. Epub 2018 Sep 21.

Department of Neurology, Medicine School, Gaziosmanpaşa University, 60200 Tokat, Turkey.

Ulegyria is a parenchymal sequel of hypoxic ischemic encephalopathy causing mushroom-like appearance in gyri. Aim of the present study was to evaluate clinico-radiological findings of patients who applied with different clinical features, predominantly epilepsy, and who were found to have ulegyria formations in MRI examinations. The study included a total of 30 patients (12 female and 18 male) who applied with different types of seizures in February 2011-August 2016 period and had brain MRI examinations using 1. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.09.006DOI Listing
December 2018
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Typical asymmetry in the hemispheric activation during an fMRI verbal comprehension paradigm is related to better performance in verbal and non-verbal tasks in patients with epilepsy.

Neuroimage Clin 2018 15;20:742-752. Epub 2018 Sep 15.

IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain; Epilepsy Unit, Department of Radiology, Hospital Clínic, Barcelona, Spain.

Chronic exposure to seizures in patients with left hemisphere (LH) epileptic focus could favor higher activation in the contralateral hemisphere during language processing, but the cognitive effects of this remain unclear. This study assesses the relationship between asymmetry in hemispheric activation during language fMRI and performance in verbal and non-verbal tasks. Whereas prior studies primarily used fMRI paradigms that favor frontal lobe activation and less prominent activation of the medial or superior temporal lobes, we used a verbal comprehension paradigm previously demonstrated to activate reliably receptive language areas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183028
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http://dx.doi.org/10.1016/j.nicl.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154460PMC
January 2019
13 Reads

Anterior Temporal Lobectomy Impairs Neural Classification of Body Emotions in Right Superior Temporal Sulcus and Reduces Emotional Enhancement in Distributed Brain Areas without Affecting Behavioral Classification.

J Neurosci 2018 Oct 18;38(43):9263-9274. Epub 2018 Sep 18.

Laboratory for Translational Neuropsychiatry, Research Group Psychiatry, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium,

Humans with amygdalar lesions show proportional reductions of the emotional response to facial expressions in the fusiform face area as well as deficits in emotion recognition from facial expressions. While processing of bodily expressions shares many similarities with facial expressions, there is no substantial evidence that lesions of the amygdala result in similar behavioral and neural sequelae. We combined behavioral assessment with functional neuroimaging in a group of male and female humans with unilateral anterior temporal lobe (ATL) resections, including the amygdala (right: = 10; left: = 10) and 12 matched controls. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0634-18.2018DOI Listing
October 2018
4 Reads

Parasomnia versus epilepsy: An affair of the heart?

Neurophysiol Clin 2018 Oct 15;48(5):277-286. Epub 2018 Sep 15.

NeuroPain Team, Inserm U 1028/CNRS, UMR 5292, University of Lyon, Lyon Neuroscience Research Centre (CRNL), 69677 Bron, France.

Objective: Differential diagnosis between sleep-related epileptic seizures and NREM parasomnia remains challenging. Pathophysiological markers to differentiate both conditions are needed. Activation of autonomic system is present in arousal reactions and epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neucli.2018.08.002DOI Listing
October 2018
4 Reads

Ictal Asystole Induced by Right Posterior Quadrant Epilepsy: Report of a Radically Treated Case.

World Neurosurg 2018 Dec 14;120:337-342. Epub 2018 Sep 14.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

Background: Ictal asystole (IA) and ictal bradycardia (IB) are mainly seen with temporal or frontal lobe epilepsy. Many patients with these conditions undergo cardiac pacemaker therapy but not epilepsy surgery.

Case Description: We report the case of a 15-year-old boy with IA and IB secondary to right posterior quadrant epilepsy (PoQE) who underwent right posterior quadrant disconnection, but not cardiac pacemaker implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183207
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http://dx.doi.org/10.1016/j.wneu.2018.09.030DOI Listing
December 2018
6 Reads