3,260 results match your criteria Free Radical Research [Journal]


Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer.

Free Radic Res 2019 Feb 18:1-11. Epub 2019 Feb 18.

c Department of Pharmaceutical Sciences , North Dakota State University , Fargo , USA.

The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-related diseases in traditional Chinese medicine. In recent years, celastrol (a natural compound from the root of the thunder god vine) has attracted great interest for its potential anticancer activities. Read More

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http://dx.doi.org/10.1080/10715762.2019.1575512DOI Listing
February 2019

Epidermal growth factor protects against myocardial ischemia reperfusion injury through activating Nrf2 signaling pathway.

Authors:
Jun Ma Ge Jin

Free Radic Res 2019 Feb 18:1-221. Epub 2019 Feb 18.

a Department of Cardiology , the Second Affiliated Hospital of Wenzhou Medical University , Wenzhou , P. R. China.

Alleviating the oxidant stress associated with myocardial ischemia reperfusion has been demonstrated as a potential therapeutic approach to limit ischemia reperfusion (I/R)-induced cardiac damage. It's reported that EGFR/erbB2 signaling is an important cardiac survival pathway in cardiac function and activation of EGFR has a cardiovascular effect in global ischemia. Epidermal growth factor (EGF), a typical EGFR ligand, was considered to have a significant role in activating EGFR. Read More

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http://dx.doi.org/10.1080/10715762.2019.1584399DOI Listing
February 2019

An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signaling pathway and prevents oxidative insults in human lung epithelial cells.

Free Radic Res 2019 Feb 18:1-161. Epub 2019 Feb 18.

a Key Laboratory of Chemical Biology (MOE) , School of Pharmaceutical Sciences , Shandong University , Jinan , People's Republic of China.

The nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in regulating the intracellular oxidative stress, and thus activation of Nrf2 by nature-derived molecules effectively alleviates the pathological process of oxidative stress-induced chronic diseases. The isopentenyl-substituted flavonoid norartocarpin (NOR) induced the activity of NAD(P)H: quinone reductase (QR), implying that it might be a potential Nrf2 activator. Further studies indicated that NOR upregulated the protein levels of Nrf2 and its downstream genes, NAD(P)H quinone oxidoreductase 1 (NQO1), and γ-glutamyl cysteine synthetase (GCLM) through facilitating the nuclear translocation of Nrf2 and enhancing Nrf2 protein stability. Read More

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http://dx.doi.org/10.1080/10715762.2019.1582769DOI Listing
February 2019

The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free Radic Res 2019 Feb 18:1-241. Epub 2019 Feb 18.

a Institute of Experimental Medicine , Chinese Academy of Sciences , Prague , Czech Republic.

Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Read More

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http://dx.doi.org/10.1080/10715762.2019.1582770DOI Listing
February 2019

Cold stress on Araucaria angustifolia embryogenic cells results in oxidative stress and induces adaptation: implications for conservation and propagation.

Free Radic Res 2019 Feb 14:1-12. Epub 2019 Feb 14.

a Department of Biochemistry and Molecular Biology , Federal University of Paraná , Curitiba , Brazil.

Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. Read More

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http://dx.doi.org/10.1080/10715762.2018.1548767DOI Listing
February 2019

Glutathione accelerates osteoclast differentiation and inflammatory bone destruction.

Free Radic Res 2019 Feb 10:1-11. Epub 2019 Feb 10.

a Department of Cytology and Histology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Chronic inflammation associated with bone tissues often destruct bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It is believed that reactive oxygen species (ROS) are involved in RANK ligand (RANKL)-induced osteoclast differentiation, and, therefore, glutathione (GSH), the most abundant endogenous antioxidant, suppresses osteoclast differentiation and bone resorption by RANKL. Read More

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http://dx.doi.org/10.1080/10715762.2018.1563782DOI Listing
February 2019

15-Deoxy-Δ-prostaglandin J upregulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation.

Free Radic Res 2019 Feb 5:1-221. Epub 2019 Feb 5.

c Department of Food and Nutrition , College of Health & Wellness , Sungshin Women's University , Seoul , South Korea.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyzes the conversion of prostaglandin E to a keto metabolite. The downregulation of 15-PGDH is ubiquitously observed in various human malignancies. However, the molecular mechanisms underlying downregulation of 15-PGDH expression remain largely unknown. Read More

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http://dx.doi.org/10.1080/10715762.2019.1576867DOI Listing
February 2019

Alpha-lipoic acid suppresses N-(carboxymethyl) lysine-induced epithelial mesenchymal transition in HK-2 human renal proximal tubule cells.

Free Radic Res 2018 Dec;52(11-12):1387-1397

c Department of Medical Laboratory Sciences and Biotechnology, College of Medical Sciences and Technology , Taipei Medical University , Taipei , Taiwan.

N-(carboxymethyl) lysine (CML) plays causal roles in diabetic complications. In the present study, we investigated whether CML-induced HIF-1α accumulation and epithelial-mesenchymal transition (EMT) in HK-2 renal proximal tubular epithelial cells. Treatment with CML-BSA increased reactive oxygen species (ROS) production reduced the mitochondrial membrane potential and induced mitochondrial fragmentation. Read More

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http://dx.doi.org/10.1080/10715762.2018.1489129DOI Listing
December 2018
1 Read

Resveratrol provides neuroprotective effects through modulation of mitochondrial dynamics and ERK1/2 regulated autophagy.

Free Radic Res 2018 Dec;52(11-12):1371-1386

a Mitochondrial Research Unit, Kaohsiung Chang Gung Memorial Hospital and Chang Gung UniversityCollege of Medicine, Kaohsiung 833, Taiwan.

Mitochondrial dysfunction and oxidative stress are underlying contributors to Parkinson's disease (PD). The reduction of aberrant proteins and dysfunctional mitochondria through constitutive autophagy is essential for neuronal survival. We investigated the neuroprotective effects of the natural red wine extract, resveratrol, on the Complex I inhibitor, rotenone-induced oxidative stress SH-SY5Y cellular model. Read More

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http://dx.doi.org/10.1080/10715762.2018.1489128DOI Listing
December 2018
1 Read

eIF2 alpha phosphorylation alleviates UVA-induced HO-1 expression in mouse epidermal cells.

Free Radic Res 2018 Dec;52(11-12):1359-1370

a Base of "111 Project" for Biomechanics & Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering college , Chongqing University , Chongqing , China.

Ultraviolet A (UVA) irradiation is a potential environmental stressor, which contributes to inflammation, photoaging, and carcinogenesis. UVA causes endoplasmic reticulum stress, hence phosphorylates the α subunit of eIF2. Meanwhile, UVA also induces expression of haem oxygenase-1 (HO-1) and nuclear factor erythroid-derived two related factor 2 (Nrf2) in human skin cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1489127DOI Listing
December 2018
5 Reads

Mitochondrial translation factor EF4 regulates oxidative phosphorylation complexes and the production of ROS.

Authors:
Guichen Li Yan Qin

Free Radic Res 2018 Dec;52(11-12):1250-1255

a Key Laboratory of RNA Biology , Institute of Biophysics, Chinese Academy of Sciences , Chaoyang District , Beijing , China.

Mitochondrial translation system executes the biosynthesis of mitochondrial DNA encoded polypeptides that are the core subunits of oxidative phosphorylation complexes. Recently, we reported that elongation factor 4 (EF4) is a key quality control factor in bacterial and mitochondrial translation regulating tRNA translocation and modulating cellular responses via a direct cross-talk with cytoplasmic translation machinery. Here, we made a brief review on mtEF4-regulated mitochondrial translation, respiratory chain biogenesis and the production of reactive oxygen species (ROS). Read More

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http://dx.doi.org/10.1080/10715762.2018.1479063DOI Listing
December 2018

Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112).

Free Radic Res 2019 Feb 22:1-8. Epub 2019 Feb 22.

r Laboratoire Bio-PeroxIL EA7270, University Bourgogne Franche-Comté , Dijon , France.

A healthy ageing process is important when it is considered that one-third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at an older age is not only an important measure of the quality of life but also key to participation and productivity. So, the binomial "nutrition and ageing" has different aspects and poses considerable challenges, providing a fertile ground for research and networks. Read More

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http://dx.doi.org/10.1080/10715762.2019.1572890DOI Listing
February 2019
2 Reads

Antipsychotic drugs scavenge radiation-induced hydroxyl radicals and intracellular ROS formation, and protect apoptosis in human lymphoma U937 cells.

Free Radic Res 2019 Feb 4:1-9. Epub 2019 Feb 4.

b Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Toyama , Japan.

Antioxidant activity has been reported for some atypical antipsychotic drugs; however, the detailed mechanism is not well known. Here, we investigated the effects of atypical antipsychotic drugs on OH radical formation, intracellular reactive oxygen species (ROS), and apoptosis induced by ionising radiation. The reaction rate constants with OH radicals were determined for five antipsychotic drugs as follows, in descending order: olanzapine, aripiprazole, clozapine, haloperidol, and risperidone. Read More

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http://dx.doi.org/10.1080/10715762.2019.1572889DOI Listing
February 2019

Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.

Free Radic Res 2019 Feb 4:1-11. Epub 2019 Feb 4.

a Chemical Biology Research Center, School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , China.

Thioredoxin reductase 1 (TrxR1) has emerged as a potential target for cancer therapy, because it is overexpressed in several types of cancers and associated with increased tumour growth and poor patient prognosis. Alantolactone (ALT), a natural sesquiterpene lactone originated from traditional folk medicine Inula helenium L., has been reported to exert antitumor activity in various tumours. Read More

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http://dx.doi.org/10.1080/10715762.2018.1558448DOI Listing
February 2019
1 Read

The Cu/Zn superoxide dismutase +35A/C (rs2234694) variant correlates with altered levels of protein carbonyls and glutathione and associates with severity of COPD in a Tunisian population.

Free Radic Res 2019 Feb 14:1-11. Epub 2019 Feb 14.

a Unité de recherche UR12ES06 Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire « Biologie, Médecine et Santé » , Faculté de Médecine de Sousse, Université de Sousse , Sousse , Tunisia.

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, the influence of these variants on inflammatory and oxidative stress parameters. Genotyping of superoxide dismutase 1 (SOD1) + 35 A/C (rs2234694), catalase [A-21T (rs7943316), C-262T (rs1001179)] and glutathione peroxidase 1 (reduced glutathione (GSH)-Px1) 198Pro/Leu (rs1050450) was carried out in 143 patients with COPD and 216 healthy controls using PCR-RFLP. Read More

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http://dx.doi.org/10.1080/10715762.2019.1572888DOI Listing
February 2019

Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects.

Free Radic Res 2019 Jan 21:1-12. Epub 2019 Jan 21.

a Department of Dermatology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.

Psoriasis is a chronic hyperproliferative skin disease characterised by excessive growth of keratinocytes. Indeed, inducing keratinocyte apoptosis is a key mechanism responsible for psoriatic plaques clearance following some important existing therapies, which display pro-oxidant activity. Cold atmospheric plasma (CAP), acting as a tuneable source of reactive oxygen and nitrogen species (RONS), can controllably transfer RONS to the cellular environment, deliver antiproliferative RONS concentrations and exert antiproliferative and proapoptotic effects. Read More

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http://dx.doi.org/10.1080/10715762.2018.1564920DOI Listing
January 2019
3 Reads

Characterisation and quantification of protein oxidative modifications and amino acid racemisation in powdered infant milk formula.

Free Radic Res 2019 Jan 16:1-14. Epub 2019 Jan 16.

a Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.

Modification of proteins in infant milk formula (IF) is of major concern to the dairy industry and consumers. Thermal treatment is required for microbiological safety, but heat, light, metal-ions and other factors may induce oxidative damage, and be a health risk. In this study protein modifications in IFs were quantified. Read More

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http://dx.doi.org/10.1080/10715762.2018.1554250DOI Listing
January 2019
1 Read

Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions.

Free Radic Res 2019 Jan 16:1-12. Epub 2019 Jan 16.

d Department of Medical Biology and Biochemistry , Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.

Melatonin supplementation has been proved to have antioxidant and anti-inflammatory effects in humans. The aim of the study was to estimate the influence of a 30-day melatonin supplementation on oxidative and inflammatory state in the blood of intense training professional athletes. The study was conducted in 47 football players, 19 rowers, and 15 adults who did not practice sports (control group). Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1563688DOI Listing
January 2019
6 Reads

Chemotherapeutic potential of novel non-toxic nucleoside analogues on EAC ascitic tumour cells.

Free Radic Res 2019 Jan 9:1-11. Epub 2019 Jan 9.

a Department of Cancer Chemoprevention , Chittaranjan National Cancer Institute , Kolkata , India.

Therapeutic efficacy of nucleoside analogues (NAs) like Gemcitabine, 5-fluorouracil in cancer treatment is already well established. Most of the known NAs are highly toxic to normal cells due to its non-specific action; thus searching for non-toxic NAs are still going on. For that purpose we have synthesised nine different NAs by alteration of their structural and functional groups. Read More

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http://dx.doi.org/10.1080/10715762.2018.1551999DOI Listing
January 2019
2 Reads

L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils.

Free Radic Res 2019 Feb 4:1-12. Epub 2019 Feb 4.

c Translational Health Science and Technology, NCR Biotech Science Cluster , Faridabad , India.

Recent report from this lab has shown role of Rac2 in the translocation of inducible nitric oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes (PMNs) following phagocytosis of beads. This study was undertaken to further assess the status and role of tetrahydrobiopterin (BH), a redox-sensitive cofactor, L-arginine, and the substrate of nitric oxide synthase (NOS) in sustained nitric oxide (˙NO) production in killing of phagocytosed microbes (Escherichia coli) by human PMNs. Time-dependent study revealed consistent NO and reactive oxygen species (ROS) production in the PMNs following phagocytosis of beads. Read More

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http://dx.doi.org/10.1080/10715762.2019.1566605DOI Listing
February 2019
1 Read

In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by particulate matter (PM10): the effective role of gallic acid.

Free Radic Res 2019 Feb 22:1-16. Epub 2019 Feb 22.

c Health Faculty, Department of Environmental Health Engineering , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Environmental pollution is one of the risk factors for respiratory diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is the major mechanisms contributing to cellular defense against oxidative damage. Gallic acid (GA) is regarded as potent anti-inflammatory and antioxidant agents. Read More

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http://dx.doi.org/10.1080/10715762.2018.1563689DOI Listing
February 2019
1 Read

Cyclophilin A and CD147 associate with progression of diabetic nephropathy.

Free Radic Res 2018 Dec 20;52(11-12):1456-1463. Epub 2018 Dec 20.

a School of Medicine , Chung Shan Medical University , Taichung , Taiwan.

To find the associations of circulating cyclophilin A (CyP A) and CD147/EMMPRIN with renal outcomes in type 2 diabetes patients and possible pathogenesis involved. Total 131 patients were recruited since 2004. Glycated hemoglobin, blood glucose and urine albumin-creatinine ratio levels at baseline and every 3 months were measured. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1523545DOI Listing
December 2018
6 Reads

Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation.

Free Radic Res 2018 Dec 20:1-191. Epub 2018 Dec 20.

a Department of Environmental and Molecular Medicine , Mie University Graduate School of Medicine , Tsu , Japan.

Morin is a potential inhibitor of amyloid β-peptide aggregation. This aggregation is involved in the pathogenesis of Alzheimer's disease. Meanwhile, morin has been found to be mutagenic and exhibits peroxidation of membrane lipids concurrent with DNA strand breaks in the presence of metal ions. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1562179DOI Listing
December 2018
7 Reads

Hydrogen peroxide constricts rat arteries by activating Na-permeable and Ca-permeable cation channels.

Free Radic Res 2018 Dec 10:1-171. Epub 2018 Dec 10.

b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.

Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More

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http://dx.doi.org/10.1080/10715762.2018.1556394DOI Listing
December 2018
2 Reads

Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signaling pathway.

Free Radic Res 2018 Dec 10:1-191. Epub 2018 Dec 10.

a Department of Pharmacology , School of Medicine , Nankai University , Tianjin , China.

According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. However, the molecular mechanism remains unclear. In this study, we investigated the protective effect of RSV on myocardial infarction (MI) in rats and further explored the underlying signal pathway after VEGF-B. Read More

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http://dx.doi.org/10.1080/10715762.2018.1554901DOI Listing
December 2018
2 Reads

Irreversible plasma and muscle protein oxidation and physical exercise.

Free Radic Res 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Biomedical, Experimental and Clinical Sciences "Mario Serio" , University of Florence , Florence , Italy.

The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidative stress may be due to an overproduction of free radicals during physical exercise. Excess of radical species leads to the modification of molecules, such as proteins - the most susceptible to oxidative modification - lipids and DNA. Read More

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http://dx.doi.org/10.1080/10715762.2018.1542141DOI Listing
December 2018
8 Reads

Methyl-mercury induces apoptosis through ROS-mediated endoplasmic reticulum stress and mitochondrial apoptosis pathways activation in rat cortical neurons.

Free Radic Res 2018 Dec 4:1-19. Epub 2018 Dec 4.

a Department of Environmental Health, School of Public Health , China Medical University , Shenyang , People's Republic of China.

Methyl-mercury (MeHg) is a dangerous environmental contamination biotransformed from mercury or inorganic mercury compounds in waterways, which induces severe toxic effects in central nervous system. Oxidative stress is involved in various ways of intracellular physiological or pathological processes including neuronal apoptosis. For understanding the ways that oxidative stress participating in MeHg-induced apoptosis, the current study attempted to explore the effects of oxidative stress on endoplasmic reticulum (ER) and mitochondria function, especially focussing on ER stress followed by unfold protein response (UPR), as well as mitochondrial apoptosis pathways activation in primary cultured cortical neurons. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1546852DOI Listing
December 2018
9 Reads

A computational investigation of the reactions of tyrosyl, tryptophanyl, and cysteinyl radicals with nitric oxide and molecular oxygen.

Free Radic Res 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Departamento de Química Inorgánica, Analítica y Química-Física and INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales , Universidad de Buenos Aires Ciudad Universitaria , Buenos Aires , Argentina.

Proteins are main targets of oxidants in biological systems. This oxidation may occur in the protein backbone as well as in certain amino acid side chains, depending on the oxidant and amino acid intrinsic reactivity. Moreover, many enzymes are capable of generating stable amino acid radicals, such as tyrosyl, tryptophanyl and cysteinyl radicals. Read More

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http://dx.doi.org/10.1080/10715762.2018.1541322DOI Listing
November 2018
12 Reads

The role of decorin in cardiovascular diseases: more than just a decoration.

Free Radic Res 2018 Dec 23;52(11-12):1210-1219. Epub 2018 Nov 23.

b National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, Cardiovascular and Metabolic Disease Center , College of Medicine, Inje University , Busan , Korea.

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. Read More

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http://dx.doi.org/10.1080/10715762.2018.1516285DOI Listing
December 2018
1 Read

Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.

Free Radic Res 2018 Dec 23;52(11-12):1220-1239. Epub 2018 Nov 23.

a School of Chinese Medicine , the University of Hong Kong , PR China.

Tissue plasminogen activator (t-PA) remains to be the only FDA-approved drug for ischaemic stroke, but it has a restrictive therapeutic window with 4.5 hours. Beyond the golden time window, thrombolytic treatment carries the risk of haemorrhagic transformation (HT). Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1521519DOI Listing
December 2018
11 Reads

Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.

Free Radic Res 2018 Nov 20:1-221. Epub 2018 Nov 20.

a Department of Critical Care Medicine , Nanfang Hospital , Southern Medical University , Guangzhou , China.

As a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, SIRT3 is highly expressed in tissues with high metabolic turnover and mitochondrial content. It has been demonstrated that SIRT3 plays a critical role in maintaining normal mitochondrial biological function through reversible protein lysine deacetylation. SIRT3 has a variety of substrates that are involved in mitochondrial biological processes such as energy metabolism, reactive oxygen species (ROS) production and clearance, electron transport chain (ETC) flux, mitochondrial membrane potential maintenance and mitochondrial dynamics. Read More

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http://dx.doi.org/10.1080/10715762.2018.1549732DOI Listing
November 2018
15 Reads

Effect of phototherapy on oxidant/antioxidant status: A randomized controlled trial.

Free Radic Res 2018 Nov 20:1-291. Epub 2018 Nov 20.

b Pediatrics Department , Military Medical Academy , Cairo , Egypt.

In order to evaluate the effect of different types of phototherapy on oxidant/antioxidant status in hyperbilirubinemic neonates, an interventional randomized control trial was conducted on 120 neonates ≥ 35 weeks' gestational age with indirect hyperbilirubinemia reaching phototherapy level. This study is registered with ClinicalTrials.gov as NCT03074292 . Read More

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http://dx.doi.org/10.1080/10715762.2018.1549364DOI Listing
November 2018
10 Reads

Oxidative DNA and RNA damage and their prognostic values during Salmonella enteritidis-induced intestinal infection in rats.

Free Radic Res 2018 Sep 13;52(9):961-969. Epub 2018 Nov 13.

b National Center of Gerontology, The MOH Key Laboratory of Geriatrics , Beijing Hospital , Beijing , P. R. China.

Emerging evidence suggests that microbial pathogens may induce oxidative stress in infected hosts. The aim of the present study was to investigate the relationship between changes in oxidative stress and intestinal infection with and without antibiotic treatment in animal models. Sprague-Dawley (SD) rats were divided into three groups: rats infected with Salmonella enterica serovar Enteritidis (S. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1500022DOI Listing
September 2018
11 Reads

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation.

Free Radic Res 2018 Nov 13:1-18. Epub 2018 Nov 13.

d Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.

Inflammation is a protective immune response against invading pathogens, however, dysregulated inflammation is detrimental. As the complex inflammatory response involves multiple mediators, including the involvement of reactive oxygen species, concomitantly targeting proinflammatory and antioxidant check-points may be a more rational strategy. We report the synthesis and anti-inflammatory/antioxidant activity of a novel indanedione derivative DMFO. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1533636DOI Listing
November 2018
9 Reads

Role of calcium in reactive oxygen species-induced apoptosis in Candida albicans: An antifungal mechanism of antimicrobial peptide, PMAP-23.

Free Radic Res 2018 Nov 7:1-211. Epub 2018 Nov 7.

a School of Life Sciences , BK21 Plus KNU Creative BioResearch Group , Kyungpook National University , Daegu , Korea.

PMAP-23 ( RIIDLLWRVRRPQKPKFVTVWVR -NH) is an antimicrobial peptide (AMP) derived from porcine myeloid. Membrane disruption is thought to underpin the anticandidal activity of PMAP-23. However, many AMPs act via mechanisms other than simple membrane permeabilization. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1511052DOI Listing
November 2018
15 Reads

3-bromopyruvate induces expression of antioxidant genes.

Free Radic Res 2018 Oct 26:1-251. Epub 2018 Oct 26.

d Department of Analytical Biochemistry , Faculty of Biology and Agriculture , University of Rzeszow , Rzeszow , Poland.

An alkylating compound, 3-bromopyruvic acid (3-3-bromopyruvic acid (BP)) is a promising anticancer agent, potentially able to act on multidrug-resistant cells. Its action has been attributed mainly to inhibition of glycolysis. This compound induces also oxidative stress at a cellular level. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1541176DOI Listing
October 2018
44 Reads

Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells.

Free Radic Res 2018 Nov 13:1-15. Epub 2018 Nov 13.

a Biomedical Magnetic Resonance , Université Catholique de Louvain, Louvain Drug Research Institute (LDRI) , Brussels , Belgium.

As superoxide anion is of keen interest in biomedical research, it is highly desirable to have a technique allowing its detection sensitively and specifically in biological media. If electron paramagnetic resonance (EPR) techniques and probes have been individually described in the literature, there is actually no comparison of these techniques in the same conditions that may help guiding researchers for selecting the most appropriate approach. The aim of the present study was to compare different EPR strategies in terms of sensitivity and specificity to detect superoxide (vs. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1541321DOI Listing
November 2018
10 Reads

Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1.

Free Radic Res 2018 Oct 23:1-211. Epub 2018 Oct 23.

a Institute of Clinical Biochemistry , Hannover Medical School , Hannover , Germany.

Hydrogen peroxide plays an important role in various biological processes in numerous organisms. Depending on the concentration and the distribution within the cell, it can act as stressor or redox signalling molecule. To analyse the effects of HO and its diffusion within the cell we developed the new genetically encoded photosensitizer KillerRed-SOD1 which enables a light-induced spatially and temporally controlled generation of HO in living cells. Read More

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http://dx.doi.org/10.1080/10715762.2018.1540042DOI Listing
October 2018
10 Reads

Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.

Free Radic Res 2018 Sep 18;52(9):952-960. Epub 2018 Oct 18.

a Department of Nephrology , the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University , Nanjing , China.

Leonurine, a major bioactive component from Herba Leonuri, shows therapeutic potential in several diseases, including diabetes, cardiovascular disease, bovine mastitis and depression. In kidney, it was reported that leonurine was performing a protective effect in both acute kidney injury and renal fibrosis mice models. The aim of this study is to investigate the effect of leonurine in podocyte injury. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1500021DOI Listing
September 2018
11 Reads

Are antioxidant parameters in serum altered in patients with relapsing-remitting multiple sclerosis treated with II-line immunomodulatory therapy?

Free Radic Res 2018 Oct;52(10):1083-1093

a Department of Neurology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.

So far little has been known about antioxidant properties of immunomodulatory drugs. The aim of the study was to evaluate the antioxidant status in serum of relapsing-remitting multiple sclerosis (RRMS) patients treated with II-line immunomodulatory therapy compared to de novo diagnosed patients, subjects treated with interferon (IFN) beta and healthy controls. We analyzed the relationships depending on the gender, age, disease duration, the Expanded Disability Status Scale, the annualised relapse rate, and MRI lesions in patients treated with II-line. Read More

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http://dx.doi.org/10.1080/10715762.2018.1535176DOI Listing
October 2018
1 Read

Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice.

Free Radic Res 2018 Sep 12;52(9):1030-1039. Epub 2018 Oct 12.

a Department of Pathology and Biological Responses , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Exposure to asbestos fiber is central to mesothelial carcinogenesis, for which iron overload in or near mesothelial cells is a key pathogenic mechanism. Alternatively, iron chelation therapy with deferasirox or regular phlebotomy was significantly preventive against crocidolite-induced mesothelial carcinogenesis in rats. However, the role of iron transporters during asbestos-induced carcinogenesis remains elusive. Read More

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http://dx.doi.org/10.1080/10715762.2018.1514604DOI Listing
September 2018
4 Reads

Analysis of selected promoter polymorphisms and haplotypes of the CYBA gene encoding the p22phox, subunit of NADPH oxidases, in patients with coronary artery disease.

Free Radic Res 2018 Oct 8:1-201. Epub 2018 Oct 8.

a School of Health Sciences in Katowice , Medical University of Silesia , Department of Biochemistry and Medical Genetics , Katowice , Poland.

Background: The p22phox is a critical component of vascular NADPH oxidases and is encoded by the CYBA gene. It was shown that functionally relevant polymorphisms of the CYBA gene - 930A>G, -852C>G , -675A>T , -536C>T, 214C>T (previously described as 242C>T), *24A>G (previously described as 640A>G), and *49A>G modulate generation of reactive oxygen species (ROS).

Aim: Analyse whether the CYBA gene polymorphisms - 852C>G, -675A>T , and - 536C>T were associated with coronary artery disease (CAD), and to designate haplotype blocks. Read More

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http://dx.doi.org/10.1080/10715762.2018.1532569DOI Listing
October 2018
6 Reads

The diverse role of TIGAR in cellular homeostasis and cancer.

Free Radic Res 2018 Dec 4;52(11-12):1240-1249. Epub 2018 Oct 4.

a Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences , Soochow University , Suzhou , PR China.

TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target protein that plays critical roles in glycolysis and redox balance. Accumulating evidence shows that TIGAR is highly expressed in cancer. TIGAR redirects glycolysis and promotes carcinoma growth by providing metabolic intermediates and reductive power derived from pentose phosphate pathway (PPP). Read More

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http://dx.doi.org/10.1080/10715762.2018.1489133DOI Listing
December 2018
4 Reads

Use of quantum-chemical descriptors to analyse reaction rate constants between organic chemicals and superoxide/hydroperoxyl (O/HO).

Free Radic Res 2018 Nov 13:1-14. Epub 2018 Nov 13.

c National Institute of Public Health and the Environment , Bilthoven , The Netherlands.

The reaction between superoxide (O) and organic chemicals is of interest in many scientific disciplines including biology and synthetic chemistry, as well as for the evaluation of chemical fate in the environment. Due to limited data and lack of congeneric modelling, the involvement of superoxide in many complex processes cannot be adequately evaluated. In this study, we developed new quantitative structure-property relationship (QSPR) models for the prediction of the aqueous-phase rate constant for the reaction between superoxide and a wide variety of organic chemicals reacting via one-electron oxidation, reduction and hydrogen-transfer. Read More

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http://dx.doi.org/10.1080/10715762.2018.1529867DOI Listing
November 2018
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A special issue of SFRR Asia: cross talk between free radicals and mitochondria in health and disease.

Free Radic Res 2018 Dec;52(11-12):1197-1198

c College of Pharmacy , Seoul National University , Gwanak-gu , Republic of Korea.

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http://dx.doi.org/10.1080/10715762.2018.1528501DOI Listing
December 2018
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Role of heme oxygenase-1 and its reaction product, carbon monoxide, in manifestation of breast cancer stem cell-like properties: Notch-1 as a putative target.

Free Radic Res 2018 Dec 21;52(11-12):1336-1347. Epub 2018 Sep 21.

a Tumor Microenvironment Global Core Research Center and Research Institute of Pharmaceutical Sciences, Seoul National University , Seoul , South Korea.

Cancer stem cells (CSCs) constitute a subpopulation of transformed cells that possess intrinsic ability to undergo selfrenewal and differentiation, which drive tumour resistance and cancer recurrence. It has been reported that CSCs possess enhanced protection against oxidative stress induced by reactive oxygen species compared with nonstem-like cancer cells. In the present work, we investigated the role of heme oxygenase-1 (HO-1), a representative antioxidant enzyme, on the stemness and selfrenewal of human breast CSCs. Read More

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http://dx.doi.org/10.1080/10715762.2018.1473571DOI Listing
December 2018
2 Reads

Oxidative/nitrative stress in the pathogenesis of systemic sclerosis: are antioxidants beneficial?

Free Radic Res 2018 Nov 13:1-20. Epub 2018 Nov 13.

a Immune Response and Vascular Disease Unit , CEDOC, Nova University , Lisboa , Portugal.

Systemic sclerosis (SSc) is a multisystem autoimmune disease: characterised from the clinical side by progressive vasculopathy and fibrosis of the skin and different organs and from the biochemical side by fibroblast deregulation with excessive production of collagen and increased expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4). The latter contributes to an overproduction of reactive oxygen species that through an autocrine loop maintains NOX4 in a state of activation. Reactive oxygen and nitrogen species are implicated in the origin and perpetuation of several clinical manifestations of SSc having vascular damage in common; attempts to dampen oxidative and nitrative stress through different agents with antioxidant properties have not translated into a sustained clinical benefit. Read More

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http://dx.doi.org/10.1080/10715762.2018.1525712DOI Listing
November 2018
1 Read

Comments to the article "Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media".

Authors:
Yasukazu Saitoh

Free Radic Res 2018 Sep;52(9):910-912

a Laboratory of Bioscience and Biotechnology for Cell Function Control, Faculty of Life and Environmental Sciences , Prefectural University of Hiroshima , Shobara , Japan.

Previously, we reported that high-dose ascorbic acid induced carcinostatic effects through hydrogen peroxide and superoxide anion radical generation-induced cell death and growth arrest in human tongue carcinoma cells. Recently, the comments and concerns related to this article were pointed out regarding especially the hydrogen peroxide generation in the experimental condition. In this article, I would like to reply to these comments and concerns and state our thoughts related to the study. Read More

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http://dx.doi.org/10.1080/10715762.2018.1524891DOI Listing
September 2018
9 Reads

Heme oxygenase-1 inhibits neointimal hyperplasia in rat by histone deacetylase 2.

Free Radic Res 2018 Sep 13:1-151. Epub 2018 Sep 13.

a Department of Cardiology , Shanghai Ruijin Hospital , Shanghai JiaoTong University School of Medicine , Shanghai , China.

It has been reported that heme oxygenase-1 (Hmox1) induction attenuates neointimal thickening. Here we further investigated the potential mechanisms regulating this important pathological process. We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this induction was attenuated after the treatment of siRNA against Hmox1. Read More

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http://dx.doi.org/10.1080/10715762.2018.1524578DOI Listing
September 2018
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Melatonin protects against myocardial ischemia-reperfusion injury by elevating Sirtuin3 expression and manganese superoxide dismutase activity.

Free Radic Res 2018 Aug;52(8):840-849

a Department of Emergency Medicine , Jinling Hospital, Medical School of Nanjing University , Nanjing , PR China.

Myocardial ischemia-reperfusion (MI/R) injury is a crucial cause for mortality throughout the world. Recent studies indicated that melatonin might exert profound cardio-protective effect in MI/R injury. However, the underlying mechanisms are not completely understood. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
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http://dx.doi.org/10.1080/10715762.2018.1461215DOI Listing
August 2018
16 Reads