3,272 results match your criteria Free Radical Research [Journal]


Radiation-induced (5'R)-and (5'S)-purine 5',8-cyclo-2'-deoxyribonucleosides in human cells: a revisited analysis of HPLC-MS/MS measurements.

Free Radic Res 2019 Apr 8:1-161. Epub 2019 Apr 8.

a Département de Médecine Nucléaire et Radiobiologie , Faculté de Médecine et des Sciences de la Santé , Université de Sherbrooke , 3001 12e Avenue Nord, Sherbrooke , Québec , Canada JIH 5N4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1605169DOI Listing

Silibinin induced apoptosis of human epidermal cancer A431 cells by promoting mitochondrial NOS.

Free Radic Res 2019 Apr 5:1-321. Epub 2019 Apr 5.

a Life Science and Biology Pharmacy College , Shenyang Pharmaceutical University , Shenhe , Shenyang , China.

The antitumor effects of silibinin are of increasing interest, though its mechanism is not yet clear. The goal of this study was to clarify the mechanism of silibinin-induced cell death in the A431 human epidermoid carcinoma cell line. We used a cell viability assay, flow cytometry, nitric oxide (NO) assay and western blotting to examine relationships between silibinin, NO generation and apoptosis in A431 cells. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2019.1603376DOI Listing
April 2019
1 Read

Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats.

Free Radic Res 2019 Apr 5:1-151. Epub 2019 Apr 5.

a Department of Ophthalmology , Faculty of Medicine , Shimane University , Izumo , Japan.

Two hundred twenty-two nanometers ultraviolet (UV) light produced by a krypton-chlorine excimer lamp is harmful to bacterial cells but not skin. However, the effects of 222-nm UV light exposure to the eye are not fully known. We evaluated acute corneal damage induced by 222- and 254-nm UV light in albino rats. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2019.1603378DOI Listing
April 2019
3 Reads

Ozone-induced damage of fibrinogen molecules: identification of oxidation sites by high-resolution mass spectrometry.

Free Radic Res 2019 Apr 1:1-651. Epub 2019 Apr 1.

a N.M. Emanuel Institute of Biochemical Physics , Russian Academy of Sciences , Moscow , Russian Federation.

Fibrinogen is highly susceptible to oxidation compared to other plasma proteins. Fibrinogen oxidation damages its structure and affects the protein function. Ozone-induced oxidative modifications of the fibrinogen Aα, Bβ, and γ polypeptide chains upon addition of various amounts of the oxidizer were studied by mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1600686DOI Listing
April 2019
1 Read

Tempus fugit….

Authors:
Michael Davies

Free Radic Res 2019 Jan;53(1)

a Department of Biomedical Sciences , University of Copenhagen , Copenhagen , Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1572891DOI Listing
January 2019

Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis.

Free Radic Res 2019 Apr 4:1-7. Epub 2019 Apr 4.

a Department of Preventive Medicine , School of Public Health and Management, Wenzhou Medical University , Wenzhou , China.

Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from China were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1595613DOI Listing

Rosmarinic acid exerts an antagonistic effect on vascular calcification by regulating the Nrf2 signalling pathway.

Free Radic Res 2019 Mar 13:1-11. Epub 2019 Mar 13.

b Tianjin Institute of Pharmaceutical Research New Drug Evaluation Co. Ltd , Tianjin , PR China.

Vascular calcification (VC) is a process in which calcium phosphate crystals deposit within the intima and middle membrane of the vascular wall. Rosmarinic acid (RA) is a common phenolic compound. It possesses antioxidation, anti-inflammatory, antimicrobial effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1558447DOI Listing
March 2019
3 Reads

Towards in vivo melanin radicals detection in melanomas by electron paramagnetic resonance (EPR) spectroscopy: a proof-of-concept study.

Free Radic Res 2019 Apr 4:1-6. Epub 2019 Apr 4.

a Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain , Brussels , Belgium.

Melanoma is the most aggressive skin tumour type. Although complete cure can be achieved when the whole tumour is resected, prognostic dramatically drops when melanoma cells reach deeper tissues and lymph nodes. Hence, there is an urgent need to develop accurate tools allowing (i) discriminating benign naevi from malignant tumours and (ii) being able to characterise melanoma infiltration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1593402DOI Listing

Ciprofloxacin-induces free radical production in rat cerebral microsomes.

Free Radic Res 2019 Mar 22:1-8. Epub 2019 Mar 22.

a Department of Pharmaceutical Toxicology, Faculty of Pharmacy , Hacettepe University , Ankara , Turkey.

In the presence of ciprofloxacin (CPFX), free radical adduct formation was demonstrated in rat cerebral microsomes using a spin trap α-(4-pyridyl-1-oxide)-N-tert-butyl-nitrone by electron spin resonance spectroscopy. Active microsomes, dihydronicotinamide-adenine dinucleotide phosphate, and ciprofloxacin were necessary for the formation of a spin trap/radical adduct. Adduct formation increased dose-dependently at 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1591622DOI Listing

Insulin resistance and diabetes in hyperthyroidism: a possible role for oxygen and nitrogen reactive species.

Free Radic Res 2019 Mar 25:1-21. Epub 2019 Mar 25.

a Dipartimento di Biologia , Università di Napoli Federico II , Napoli , Italy.

In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose tolerance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1590567DOI Listing
March 2019
2 Reads

Advanced glycation end-products disrupt human endothelial cells redox homeostasis: new insights into reactive oxygen species production.

Free Radic Res 2019 Mar 1:1-20. Epub 2019 Mar 1.

a Université de La Réunion, INSERM, UMR 1188 Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI) , Saint-Denis de La Réunion , France.

Advanced glycation end-products (AGEs) trigger multiple metabolic disorders in the vessel wall that may in turn lead to endothelial dysfunction. The molecular mechanisms by which AGEs generate these effects are not completely understood. Oxidative stress plays a key role in the development of deleterious effects that occur in endothelium during diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1529866DOI Listing

Circulating markers of nitric oxide homeostasis and cardiometabolic diseases: insights from population-based studies.

Free Radic Res 2019 Mar 1:1-471. Epub 2019 Mar 1.

c Endocrine Physiology Research Center , Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Emerging data suggest that impaired nitric oxide (NO) homeostasis has a key role in development of cardiometabolic disorders. The association between circulating levels of NO metabolites, ie nitrate and nitrite (NOx), and risk of chronic diseases has not yet been fully clarified. This work aims to address epidemiologic aspects of NO metabolism and discusses different physiologic and pathophysiologic conditions influencing circulating NOx. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1587168DOI Listing
March 2019
4 Reads

Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer.

Free Radic Res 2019 Feb 18:1-11. Epub 2019 Feb 18.

c Department of Pharmaceutical Sciences , North Dakota State University , Fargo , USA.

The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-related diseases in traditional Chinese medicine. In recent years, celastrol (a natural compound from the root of the thunder god vine) has attracted great interest for its potential anticancer activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1575512DOI Listing
February 2019

Epidermal growth factor protects against myocardial ischaemia reperfusion injury through activating Nrf2 signalling pathway.

Authors:
Jun Ma Ge Jin

Free Radic Res 2019 Mar 7:1-11. Epub 2019 Mar 7.

a Department of Cardiology , the Second Affiliated Hospital of Wenzhou Medical University , Wenzhou , P. R. China.

Alleviating the oxidant stress associated with myocardial ischaemia reperfusion has been demonstrated as a potential therapeutic approach to limit ischaemia reperfusion (I/R)-induced cardiac damage. It is reported that EGFR/erbB2 signalling is an important cardiac survival pathway in cardiac function and activation of EGFR has a cardiovascular effect in global ischaemia. Epidermal growth factor (EGF), a typical EGFR ligand, was considered to have a significant role in activating EGFR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1584399DOI Listing

An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.

Free Radic Res 2019 Mar 7:1-11. Epub 2019 Mar 7.

a Key Laboratory of Chemical Biology (MOE) School of Pharmaceutical Sciences , Shandong University , Jinan , People's Republic of China.

The nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in regulating the intracellular oxidative stress, and thus activation of Nrf2 by nature-derived molecules effectively alleviates the pathological process of oxidative stress-induced chronic diseases. The isopentenyl-substituted flavonoid norartocarpin (NOR) induced the activity of NAD(P)H: quinone reductase (QR), implying that it might be a potential Nrf2 activator. Further studies indicated that NOR upregulated the protein levels of Nrf2 and its downstream genes, NAD(P)H quinone oxidoreductase 1 (NQO1), and γ-glutamyl cysteine synthetase (GCLM) through facilitating the nuclear translocation of Nrf2 and enhancing Nrf2 protein stability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1582769DOI Listing

The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.

Free Radic Res 2019 Mar 19:1-11. Epub 2019 Mar 19.

a Institute of Experimental Medicine , Czech Academy of Sciences , Prague , Czech Republic.

Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1582770DOI Listing

Cold stress on Araucaria angustifolia embryogenic cells results in oxidative stress and induces adaptation: implications for conservation and propagation.

Free Radic Res 2019 Jan 14;53(1):45-56. Epub 2019 Feb 14.

a Department of Biochemistry and Molecular Biology , Federal University of Paraná , Curitiba , Brazil.

Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1548767DOI Listing
January 2019

Glutathione accelerates osteoclast differentiation and inflammatory bone destruction.

Free Radic Res 2019 Mar 1:1-11. Epub 2019 Mar 1.

a Department of Cytology and Histology , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Chronic inflammation associated with bone tissues often destructs bones, which is essentially performed by osteoclasts in the presence of immunoregulatory molecules. Hence, regulating osteoclastogenesis is crucial to develop therapeutics for bone-destructive inflammatory diseases. It is believed that reactive oxygen species (ROS) are involved in receptor activator of NF-κB (RANK) ligand (RANKL)-induced osteoclast differentiation, and, therefore, glutathione (GSH), the most abundant endogenous antioxidant, suppresses osteoclast differentiation and bone resorption by RANKL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1563782DOI Listing
March 2019
3 Reads

15-Deoxy-Δ-prostaglandin J up-regulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation.

Free Radic Res 2019 Mar 1:1-13. Epub 2019 Mar 1.

c Department of Food and Nutrition, College of Health & Wellness , Sungshin Women's University , Seoul , South Korea.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyses the conversion of prostaglandin E to a keto metabolite. The expression of 15-PGDH is ubiquitously repressed in various human malignancies. However, the molecular mechanisms underlying down-regulation of 15-PGDH expression remain largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1576867DOI Listing

Alpha-lipoic acid suppresses N-(carboxymethyl) lysine-induced epithelial mesenchymal transition in HK-2 human renal proximal tubule cells.

Free Radic Res 2018 Dec;52(11-12):1387-1397

c Department of Medical Laboratory Sciences and Biotechnology, College of Medical Sciences and Technology , Taipei Medical University , Taipei , Taiwan.

N-(carboxymethyl) lysine (CML) plays causal roles in diabetic complications. In the present study, we investigated whether CML-induced HIF-1α accumulation and epithelial-mesenchymal transition (EMT) in HK-2 renal proximal tubular epithelial cells. Treatment with CML-BSA increased reactive oxygen species (ROS) production reduced the mitochondrial membrane potential and induced mitochondrial fragmentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1489129DOI Listing
December 2018
1 Read

Resveratrol provides neuroprotective effects through modulation of mitochondrial dynamics and ERK1/2 regulated autophagy.

Free Radic Res 2018 Dec;52(11-12):1371-1386

a Mitochondrial Research Unit, Kaohsiung Chang Gung Memorial Hospital and Chang Gung UniversityCollege of Medicine, Kaohsiung 833, Taiwan.

Mitochondrial dysfunction and oxidative stress are underlying contributors to Parkinson's disease (PD). The reduction of aberrant proteins and dysfunctional mitochondria through constitutive autophagy is essential for neuronal survival. We investigated the neuroprotective effects of the natural red wine extract, resveratrol, on the Complex I inhibitor, rotenone-induced oxidative stress SH-SY5Y cellular model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1489128DOI Listing
December 2018
3 Reads

eIF2 alpha phosphorylation alleviates UVA-induced HO-1 expression in mouse epidermal cells.

Free Radic Res 2018 Dec;52(11-12):1359-1370

a Base of "111 Project" for Biomechanics & Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering college , Chongqing University , Chongqing , China.

Ultraviolet A (UVA) irradiation is a potential environmental stressor, which contributes to inflammation, photoaging, and carcinogenesis. UVA causes endoplasmic reticulum stress, hence phosphorylates the α subunit of eIF2. Meanwhile, UVA also induces expression of haem oxygenase-1 (HO-1) and nuclear factor erythroid-derived two related factor 2 (Nrf2) in human skin cells. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1489127DOI Listing
December 2018
13 Reads

Mitochondrial translation factor EF4 regulates oxidative phosphorylation complexes and the production of ROS.

Authors:
Guichen Li Yan Qin

Free Radic Res 2018 Dec;52(11-12):1250-1255

a Key Laboratory of RNA Biology , Institute of Biophysics, Chinese Academy of Sciences , Chaoyang District , Beijing , China.

Mitochondrial translation system executes the biosynthesis of mitochondrial DNA encoded polypeptides that are the core subunits of oxidative phosphorylation complexes. Recently, we reported that elongation factor 4 (EF4) is a key quality control factor in bacterial and mitochondrial translation regulating tRNA translocation and modulating cellular responses via a direct cross-talk with cytoplasmic translation machinery. Here, we made a brief review on mtEF4-regulated mitochondrial translation, respiratory chain biogenesis and the production of reactive oxygen species (ROS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1479063DOI Listing
December 2018
1 Read

Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112).

Free Radic Res 2019 Feb 22:1-8. Epub 2019 Feb 22.

r Laboratoire Bio-PeroxIL EA7270, University Bourgogne Franche-Comté , Dijon , France.

A healthy ageing process is important when it is considered that one-third of the population of Europe is already over 50 years old, although there are regional variations. This proportion is likely to increase in the future, and maintenance of vitality at an older age is not only an important measure of the quality of life but also key to participation and productivity. So, the binomial "nutrition and ageing" has different aspects and poses considerable challenges, providing a fertile ground for research and networks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1572890DOI Listing
February 2019
2 Reads

Antipsychotic drugs scavenge radiation-induced hydroxyl radicals and intracellular ROS formation, and protect apoptosis in human lymphoma U937 cells.

Free Radic Res 2019 Feb 4:1-9. Epub 2019 Feb 4.

b Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Toyama , Japan.

Antioxidant activity has been reported for some atypical antipsychotic drugs; however, the detailed mechanism is not well known. Here, we investigated the effects of atypical antipsychotic drugs on OH radical formation, intracellular reactive oxygen species (ROS), and apoptosis induced by ionising radiation. The reaction rate constants with OH radicals were determined for five antipsychotic drugs as follows, in descending order: olanzapine, aripiprazole, clozapine, haloperidol, and risperidone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1572889DOI Listing
February 2019

Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.

Free Radic Res 2019 Jan 4;53(1):104-114. Epub 2019 Feb 4.

a Chemical Biology Research Center, School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou , China.

Thioredoxin reductase 1 (TrxR1) has emerged as a potential target for cancer therapy, because it is overexpressed in several types of cancers and associated with increased tumour growth and poor patient prognosis. Alantolactone (ALT), a natural sesquiterpene lactone originated from traditional folk medicine Inula helenium L., has been reported to exert antitumor activity in various tumours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1558448DOI Listing
January 2019
1 Read

The Cu/Zn superoxide dismutase +35A/C (rs2234694) variant correlates with altered levels of protein carbonyls and glutathione and associates with severity of COPD in a Tunisian population.

Free Radic Res 2019 Feb 14:1-11. Epub 2019 Feb 14.

a Unité de recherche UR12ES06 Physiologie de l'Exercice et Physiopathologie: de l'Intégré au Moléculaire « Biologie, Médecine et Santé » , Faculté de Médecine de Sousse, Université de Sousse , Sousse , Tunisia.

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, the influence of these variants on inflammatory and oxidative stress parameters. Genotyping of superoxide dismutase 1 (SOD1) + 35 A/C (rs2234694), catalase [A-21T (rs7943316), C-262T (rs1001179)] and glutathione peroxidase 1 (reduced glutathione (GSH)-Px1) 198Pro/Leu (rs1050450) was carried out in 143 patients with COPD and 216 healthy controls using PCR-RFLP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1572888DOI Listing
February 2019

Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects.

Free Radic Res 2019 Jan 21:1-12. Epub 2019 Jan 21.

a Department of Dermatology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.

Psoriasis is a chronic hyperproliferative skin disease characterised by excessive growth of keratinocytes. Indeed, inducing keratinocyte apoptosis is a key mechanism responsible for psoriatic plaques clearance following some important existing therapies, which display pro-oxidant activity. Cold atmospheric plasma (CAP), acting as a tuneable source of reactive oxygen and nitrogen species (RONS), can controllably transfer RONS to the cellular environment, deliver antiproliferative RONS concentrations and exert antiproliferative and proapoptotic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1564920DOI Listing
January 2019
13 Reads

Characterisation and quantification of protein oxidative modifications and amino acid racemisation in powdered infant milk formula.

Free Radic Res 2019 Jan 16;53(1):68-81. Epub 2019 Jan 16.

a Department of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.

Modification of proteins in infant milk formula (IF) is of major concern to the dairy industry and consumers. Thermal treatment is required for microbiological safety, but heat, light, metal-ions and other factors may induce oxidative damage, and be a health risk. In this study protein modifications in IFs were quantified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1554250DOI Listing
January 2019
2 Reads

Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions.

Free Radic Res 2019 Jan 16:1-12. Epub 2019 Jan 16.

d Department of Medical Biology and Biochemistry , Ludwik Rydygier Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.

Melatonin supplementation has been proved to have antioxidant and anti-inflammatory effects in humans. The aim of the study was to estimate the influence of a 30-day melatonin supplementation on oxidative and inflammatory state in the blood of intense training professional athletes. The study was conducted in 47 football players, 19 rowers, and 15 adults who did not practice sports (control group). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1563688DOI Listing
January 2019
18 Reads

Chemotherapeutic potential of novel non-toxic nucleoside analogues on EAC ascitic tumour cells.

Free Radic Res 2019 Jan 9;53(1):57-67. Epub 2019 Jan 9.

a Department of Cancer Chemoprevention , Chittaranjan National Cancer Institute , Kolkata , India.

Therapeutic efficacy of nucleoside analogues (NAs) like Gemcitabine, 5-fluorouracil in cancer treatment is already well established. Most of the known NAs are highly toxic to normal cells due to its non-specific action; thus searching for non-toxic NAs are still going on. For that purpose we have synthesised nine different NAs by alteration of their structural and functional groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1551999DOI Listing
January 2019
2 Reads

L-Arginine and tetrahydrobiopterin supported nitric oxide production is crucial for the microbicidal activity of neutrophils.

Free Radic Res 2019 Feb 4:1-12. Epub 2019 Feb 4.

c Translational Health Science and Technology, NCR Biotech Science Cluster , Faridabad , India.

Recent report from this lab has shown role of Rac2 in the translocation of inducible nitric oxide synthase (iNOS) to the phagosomal compartment of polymorphonuclear leukocytes (PMNs) following phagocytosis of beads. This study was undertaken to further assess the status and role of tetrahydrobiopterin (BH), a redox-sensitive cofactor, L-arginine, and the substrate of nitric oxide synthase (NOS) in sustained nitric oxide (˙NO) production in killing of phagocytosed microbes (Escherichia coli) by human PMNs. Time-dependent study revealed consistent NO and reactive oxygen species (ROS) production in the PMNs following phagocytosis of beads. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2019.1566605DOI Listing
February 2019
1 Read

In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by particulate matter (PM10): the effective role of gallic acid.

Free Radic Res 2019 Feb 22:1-16. Epub 2019 Feb 22.

c Health Faculty, Department of Environmental Health Engineering , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Environmental pollution is one of the risk factors for respiratory diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is the major mechanisms contributing to cellular defense against oxidative damage. Gallic acid (GA) is regarded as potent anti-inflammatory and antioxidant agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1563689DOI Listing
February 2019
1 Read

Cyclophilin A and CD147 associate with progression of diabetic nephropathy.

Free Radic Res 2018 Dec 20;52(11-12):1456-1463. Epub 2018 Dec 20.

a School of Medicine , Chung Shan Medical University , Taichung , Taiwan.

To find the associations of circulating cyclophilin A (CyP A) and CD147/EMMPRIN with renal outcomes in type 2 diabetes patients and possible pathogenesis involved. Total 131 patients were recruited since 2004. Glycated hemoglobin, blood glucose and urine albumin-creatinine ratio levels at baseline and every 3 months were measured. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1523545DOI Listing
December 2018
13 Reads

Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation.

Free Radic Res 2019 Jan 2;53(1):115-123. Epub 2019 Jan 2.

a Department of Environmental and Molecular Medicine , Mie University Graduate School of Medicine , Tsu , Japan.

Morin is a potential inhibitor of amyloid β-peptide aggregation. This aggregation is involved in the pathogenesis of Alzheimer's disease. Meanwhile, morin has been found to be mutagenic and exhibits peroxidation of membrane lipids concurrent with DNA strand breaks in the presence of metal ions. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1562179DOI Listing
January 2019
10 Reads

Hydrogen peroxide constricts rat arteries by activating Na-permeable and Ca-permeable cation channels.

Free Radic Res 2019 Jan 9;53(1):94-103. Epub 2019 Jan 9.

b Department of Emergency Medical Services , Eulji University , Seongnam , Republic of Korea.

Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCC) and elevates [Ca] in many cells. However, how oxidative stress activates VDCC under clinical setting and the consequence for arteries are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1556394DOI Listing
January 2019
2 Reads

Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signalling pathway.

Free Radic Res 2019 Jan 9;53(1):82-93. Epub 2019 Jan 9.

a Department of Pharmacology, School of Medicine , Nankai University , Tianjin , China.

According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. However, the molecular mechanism remains unclear. In this study, we investigated the protective effect of RSV on myocardial infarction (MI) in rats and further explored the underlying signal pathway after VEGF-B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1554901DOI Listing
January 2019
4 Reads

Irreversible plasma and muscle protein oxidation and physical exercise.

Free Radic Res 2018 Dec 4:1-12. Epub 2018 Dec 4.

a Department of Biomedical, Experimental and Clinical Sciences "Mario Serio" , University of Florence , Florence , Italy.

The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidative stress may be due to an overproduction of free radicals during physical exercise. Excess of radical species leads to the modification of molecules, such as proteins - the most susceptible to oxidative modification - lipids and DNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1542141DOI Listing
December 2018
10 Reads

Methyl-mercury induces apoptosis through ROS-mediated endoplasmic reticulum stress and mitochondrial apoptosis pathways activation in rat cortical neurons.

Free Radic Res 2019 Jan 4;53(1):26-44. Epub 2018 Dec 4.

a Department of Environmental Health, School of Public Health , China Medical University , Shenyang , People's Republic of China.

Methyl-mercury (MeHg) is a dangerous environmental contamination biotransformed from mercury or inorganic mercury compounds in waterways, which induces severe toxic effects in central nervous system. Oxidative stress is involved in various ways of intracellular physiological or pathological processes including neuronal apoptosis. For understanding the ways that oxidative stress participating in MeHg-induced apoptosis, the current study attempted to explore the effects of oxidative stress on endoplasmic reticulum (ER) and mitochondria function, especially focussing on ER stress followed by unfold protein response (UPR), as well as mitochondrial apoptosis pathways activation in primary cultured cortical neurons. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1546852DOI Listing
January 2019
14 Reads

A computational investigation of the reactions of tyrosyl, tryptophanyl, and cysteinyl radicals with nitric oxide and molecular oxygen.

Free Radic Res 2019 Jan 23;53(1):18-25. Epub 2018 Nov 23.

a Departamento de Química Inorgánica, Analítica y Química-Física and INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales , Universidad de Buenos Aires Ciudad Universitaria , Buenos Aires , Argentina.

Proteins are main targets of oxidants in biological systems. This oxidation may occur in the protein backbone as well as in certain amino acid side chains, depending on the oxidant and amino acid intrinsic reactivity. Moreover, many enzymes are capable of generating stable amino acid radicals, such as tyrosyl, tryptophanyl and cysteinyl radicals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1541322DOI Listing
January 2019
19 Reads

The role of decorin in cardiovascular diseases: more than just a decoration.

Free Radic Res 2018 Dec 23;52(11-12):1210-1219. Epub 2018 Nov 23.

b National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, Cardiovascular and Metabolic Disease Center , College of Medicine, Inje University , Busan , Korea.

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1516285DOI Listing
December 2018
3 Reads

Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.

Free Radic Res 2018 Dec 23;52(11-12):1220-1239. Epub 2018 Nov 23.

a School of Chinese Medicine , the University of Hong Kong , PR China.

Tissue plasminogen activator (t-PA) remains to be the only FDA-approved drug for ischaemic stroke, but it has a restrictive therapeutic window with 4.5 hours. Beyond the golden time window, thrombolytic treatment carries the risk of haemorrhagic transformation (HT). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1521519DOI Listing
December 2018
14 Reads

Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.

Free Radic Res 2018 Nov 20:1-221. Epub 2018 Nov 20.

a Department of Critical Care Medicine , Nanfang Hospital , Southern Medical University , Guangzhou , China.

As a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, SIRT3 is highly expressed in tissues with high metabolic turnover and mitochondrial content. It has been demonstrated that SIRT3 plays a critical role in maintaining normal mitochondrial biological function through reversible protein lysine deacetylation. SIRT3 has a variety of substrates that are involved in mitochondrial biological processes such as energy metabolism, reactive oxygen species (ROS) production and clearance, electron transport chain (ETC) flux, mitochondrial membrane potential maintenance and mitochondrial dynamics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1549732DOI Listing
November 2018
22 Reads

Effect of phototherapy on oxidant/antioxidant status: a randomized controlled trial.

Free Radic Res 2019 Mar 1:1-8. Epub 2019 Mar 1.

b Pediatrics Department , Military Medical Academy , Cairo , Egypt.

In order to evaluate the effect of different types of phototherapy on oxidant/antioxidant status in hyperbilirubinemic neonates, an interventional randomized control trial was conducted on 120 neonates ≥35 weeks' gestational age with indirect hyperbilirubinemia reaching phototherapy level. This study is registered with ClinicalTrials.gov as NCT03074292. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1549364DOI Listing
March 2019
23 Reads

Oxidative DNA and RNA damage and their prognostic values during Salmonella enteritidis-induced intestinal infection in rats.

Free Radic Res 2018 Sep 13;52(9):961-969. Epub 2018 Nov 13.

b National Center of Gerontology, The MOH Key Laboratory of Geriatrics , Beijing Hospital , Beijing , P. R. China.

Emerging evidence suggests that microbial pathogens may induce oxidative stress in infected hosts. The aim of the present study was to investigate the relationship between changes in oxidative stress and intestinal infection with and without antibiotic treatment in animal models. Sprague-Dawley (SD) rats were divided into three groups: rats infected with Salmonella enterica serovar Enteritidis (S. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1500022DOI Listing
September 2018
17 Reads

A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation.

Free Radic Res 2018 Nov 13:1-18. Epub 2018 Nov 13.

d Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.

Inflammation is a protective immune response against invading pathogens, however, dysregulated inflammation is detrimental. As the complex inflammatory response involves multiple mediators, including the involvement of reactive oxygen species, concomitantly targeting proinflammatory and antioxidant check-points may be a more rational strategy. We report the synthesis and anti-inflammatory/antioxidant activity of a novel indanedione derivative DMFO. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1533636DOI Listing
November 2018
15 Reads

Role of calcium in reactive oxygen species-induced apoptosis in Candida albicans: an antifungal mechanism of antimicrobial peptide, PMAP-23.

Free Radic Res 2019 Jan 9;53(1):8-17. Epub 2019 Jan 9.

a School of Life Sciences, BK21 Plus KNU Creative BioResearch Group , Kyungpook National University , Daegu , Korea.

PMAP-23 (RIIDLLWRVRRPQKPKFVTVWVR-NH) is an antimicrobial peptide (AMP) derived from porcine myeloid. Membrane disruption is thought to underpin the anticandidal activity of PMAP-23. However, many AMPs act via mechanisms other than simple membrane permeabilisation. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1511052DOI Listing
January 2019
18 Reads

3-Bromopyruvate induces expression of antioxidant genes.

Free Radic Res 2019 Mar 19:1-9. Epub 2019 Mar 19.

d Department of Analytical Biochemistry Faculty of Biology and Agriculture , University of Rzeszow , Rzeszow , Poland.

An alkylating compound, 3-bromopyruvic acid (3-3-bromopyruvic acid (BP)) is a promising anti-cancer agent, potentially able to act on multidrug-resistant cells. Its action has been attributed mainly to inhibition of glycolysis. This compound induces also oxidative stress at a cellular level. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1541176DOI Listing
March 2019
64 Reads

Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells.

Free Radic Res 2018 Nov 13:1-15. Epub 2018 Nov 13.

a Biomedical Magnetic Resonance , Université Catholique de Louvain, Louvain Drug Research Institute (LDRI) , Brussels , Belgium.

As superoxide anion is of keen interest in biomedical research, it is highly desirable to have a technique allowing its detection sensitively and specifically in biological media. If electron paramagnetic resonance (EPR) techniques and probes have been individually described in the literature, there is actually no comparison of these techniques in the same conditions that may help guiding researchers for selecting the most appropriate approach. The aim of the present study was to compare different EPR strategies in terms of sensitivity and specificity to detect superoxide (vs. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10715762.2018.1
Publisher Site
http://dx.doi.org/10.1080/10715762.2018.1541321DOI Listing
November 2018
11 Reads

Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1.

Free Radic Res 2018 Oct 23:1-211. Epub 2018 Oct 23.

a Institute of Clinical Biochemistry , Hannover Medical School , Hannover , Germany.

Hydrogen peroxide plays an important role in various biological processes in numerous organisms. Depending on the concentration and the distribution within the cell, it can act as stressor or redox signalling molecule. To analyse the effects of HO and its diffusion within the cell we developed the new genetically encoded photosensitizer KillerRed-SOD1 which enables a light-induced spatially and temporally controlled generation of HO in living cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715762.2018.1540042DOI Listing
October 2018
13 Reads