31,033 results match your criteria Free Radical Biology & Medicine[Journal]


Preparation and Characterization of Curcumin-Loaded Polymeric Nanomicelles to Interference with Amyloidogenesis through Glycation Method.

Biotechnol Appl Biochem 2019 Apr 16. Epub 2019 Apr 16.

Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran.

Amyloid fibrils, including β-amyloid (Aβ) fibrils, are protein aggregates that form under certain conditions, associated with neurodegeneration that interfere with neural synaptic transmission resulting in some neural disorders, such as Alzheimer disease. The aim of this study is to inhibit amyloidogenesis by using preparatory polymeric nanomicelles as therapeutic agents and also as nano carriers for curcumin to target Aβ fibrils through the glycation method of Bovine Serum Albumin (BSA) in the presence of Phosphate Buffer Saline (PBS). Polymeric nanomicelles were prepared from Phosphatidylethanolamine-distearoyl methoxypolyethylene glycol conjugates in the presence and absence of Curcumin and then the morphological and structural characteristics of the nanomicelles were characterized in detail. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bab.1751
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http://dx.doi.org/10.1002/bab.1751DOI Listing
April 2019
1 Read

Phytochemical analysis and evaluation of antioxidant and antimycobacterial activity of Colletia paradoxa from Brazil.

Nat Prod Res 2019 Apr 16:1-5. Epub 2019 Apr 16.

a Postgraduate Program in Pharmaceutical Sciences , Universidade Federal de Santa Maria , Santa Maria , RS , Brazil.

Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Read More

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https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1
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http://dx.doi.org/10.1080/14786419.2019.1598987DOI Listing
April 2019
1 Read

Mitochondrial Theory of Skeletal Muscle Ageing - New Facts, New Doubts.

J Vet Res 2019 Mar 22;63(1):149-160. Epub 2019 Mar 22.

Department of Animal Physiology, Physiotherapy and Nutrition, Faculty of Animal Breeding and Biology, UTP University of Science and Technology, 85-084 Bydgoszcz, Poland.

For many years, scientists have been pursuing research on skeletal muscle ageing both in humans and animals. Studies on animal models have extended our knowledge of this mechanism in humans. Most researchers agree that the major processes of muscle ageing occur in the mitochondria as the major energy production centres in muscle cells. Read More

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https://content.sciendo.com/view/journals/jvetres/63/1/artic
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http://dx.doi.org/10.2478/jvetres-2019-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458556PMC
March 2019
1 Read

A Cross-Linker-Based Poly(Ionic Liquid) for Sensitive Electrochemical Detection of 4-Nonylphenol.

Nanomaterials (Basel) 2019 Apr 2;9(4). Epub 2019 Apr 2.

MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Institute of Nanomedicine and Nanobiosensing, College of Chemistry, Fuzhou University, Fuzhou 350116, China.

In this study, we report a cross-linker-based poly(ionic liquid) (PIL) for the sensitive detection of 4-nonylphenol (4-NP). PIL was poly(1,4-butanediyl-3,3'-bis-l-vinylimidazolium dibromide) (poly([V₂C₄(mim)₂]Br₂)). Poly([V₂C₄(mim)₂]Br₂) was prepared via one-step free-radical polymerization. Read More

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https://www.mdpi.com/2079-4991/9/4/513
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http://dx.doi.org/10.3390/nano9040513DOI Listing
April 2019
1 Read

Fabrication of novel magnetic MnFeO/bio-char composite and heterogeneous photo-Fenton degradation of tetracycline in near neutral pH.

Chemosphere 2019 Jun 2;224:910-921. Epub 2019 Mar 2.

Faculty of Life Science and Technology, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China.

Iron-based magnetic materials are deemed to be promising catalysts for various catalytic reactions and can be recovered conveniently by an external magnetic field. MnFeO nanoparticle and MnFeO/bio-char composite with different bio-char contents were prepared to activate hydrogen peroxide for the degradation of tetracycline (TC). The catalysts were characterized by SEM, BET, XRD, FTIR, VSM and XPS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193042
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http://dx.doi.org/10.1016/j.chemosphere.2019.02.193DOI Listing
June 2019
1 Read

Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.

Sci Rep 2019 Apr 12;9(1):6005. Epub 2019 Apr 12.

The Cytometry, Screening and Imaging Core Facility & Border Biomedical Research Center & Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.

Oxidative stress plays a critical role in numerous diseases. Therefore, the pursuit of compounds with antioxidant activity remains critical. Green barley young leaves aqueous extract (GB) was tested for its capacity to ameliorate cellular oxidative stress, and its potential cytoprotective mechanism was partially elucidated. Read More

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http://www.nature.com/articles/s41598-019-42228-4
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http://dx.doi.org/10.1038/s41598-019-42228-4DOI Listing
April 2019
2 Reads

The chemical composition of a cold-pressed milk thistle seed flour extract, and its potential health beneficial properties.

Food Funct 2019 Apr 12. Epub 2019 Apr 12.

Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.

Cold-pressed milk thistle seed flour was extracted with 50% acetone and evaluated for its phytochemical composition, and gut microbiota modulating, free radical scavenging, anti-inflammatory and anti-proliferative capacities. UHPLC-MS analysis detected fifteen compounds in the milk thistle seed flour extract with silychristin as the primary component followed by silybin B and isosilybins A & B. The milk thistle seed flour extract enhanced the total bacteria number and altered the abundance of a specific bacterial phylum or genus under the experimental conditions. Read More

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http://xlink.rsc.org/?DOI=C9FO00377K
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http://dx.doi.org/10.1039/c9fo00377kDOI Listing
April 2019
2 Reads

The current role of circulating biomarkers in non-muscle invasive bladder cancer.

Transl Androl Urol 2019 Feb;8(1):61-75

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Non-muscle invasive bladder cancer (NMIBC) is characterized by its high rate of disease recurrence and relevant disease progression rates. Up to today clinical models are insufficiently predicting outcomes for reliable patient counseling and treatment decision-making. This particularly is a serious problem in patients with high-risk NMIBC who are at high risk for failure of local treatment and thus candidates for early radical cystectomy or even systemic (neoadjuvant) chemotherapy. Read More

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http://dx.doi.org/10.21037/tau.2018.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414344PMC
February 2019
2 Reads

Methyl jasmonate and cyclodextrin-mediated defense mechanism and protective effect in response to paraquat-induced stress in peanut hairy root.

Phytochemistry 2019 Apr 8;163:11-22. Epub 2019 Apr 8.

Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand. Electronic address:

Plant cells have a variety of defense mechanisms to alleviate the deleterious effects of oxidative stress. The present work elucidated a schematic diagram of the proposed pathway of peanut hairy root tissue treated with different elicitors; paraquat (PQ), methyl jasmonate (MeJA), and cyclodextrin (CD). The different elicitation approaches could provoke intrinsic stress in plant cells and might activate a distinct response pathway, allowing plants to overcome the deleterious effects of oxidative stress. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.03.017DOI Listing

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents.

Acta Pharm Sin B 2019 Mar 7;9(2):335-350. Epub 2019 Jan 7.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437665PMC
March 2019
2 Reads

Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes.

Sci Rep 2019 Apr 10;9(1):5864. Epub 2019 Apr 10.

Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina, UEL, Londrina, PR, Brazil.

Metformin was shown to sensitize multidrug resistant breast cancer cells; however, the mechanisms involved in this capacity need to be clarified. We investigated oxidative stress and inflammatory-related pathways during the induction of doxorubicin resistance in MCF-7 and MDA-MB-231 human breast cancer cells (DOX-res group), and evaluated metformin-induced cellular responses that resulted in the prevention of doxorubicin resistance (Met-DOX group). Microarray analysis demonstrated that DOX-res changed the expression of genes involved in oxidative stress (OS) and the TGF- β1 pathway. Read More

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http://dx.doi.org/10.1038/s41598-019-42357-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458149PMC
April 2019
3 Reads

Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications.

Polymers (Basel) 2018 Apr 18;10(4). Epub 2018 Apr 18.

Center for Natural and Human Sciences, Universidade Federal do ABC, Av. dos Estados 5001, Santo André, SP, CEP 09210-580, Brazil.

Nitric oxide (NO) is involved in physiological processes, including vasodilatation, wound healing and antibacterial activities. As NO is a free radical, designing drugs to generate therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor -nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL)-chitosan (CS) hydrogel, with an easy and economically feasible methodology. Read More

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http://dx.doi.org/10.3390/polym10040452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415216PMC

Antioxidant Activity and Antifungal Activity of Chitosan Derivatives with Propane Sulfonate Groups.

Polymers (Basel) 2018 Apr 3;10(4). Epub 2018 Apr 3.

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

We successfully synthesized the water-soluble chitosan derivatives propane sulfonated chitosan (PSCS) and dipropane sulfonated chitosan (DPSCS) in this paper. These derivatives were characterized by FTIR, ¹H NMR, and C NMR. Moreover, the antioxidant activity of the chitosan derivatives was evaluated by free radical scavenging ability (against DPPH-radical, hydroxyl-radical, and superoxide-radical) and ferric reducing power. Read More

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http://dx.doi.org/10.3390/polym10040395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415242PMC

Recent Advances in RAFT Polymerization: Novel Initiation Mechanisms and Optoelectronic Applications.

Polymers (Basel) 2018 Mar 14;10(3). Epub 2018 Mar 14.

Key Laboratory for Advanced Materials and Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Applied Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Reversible addition-fragmentation chain transfer (RAFT) is considered to be one of most famous reversible deactivation radical polymerization protocols. Benefiting from its living or controlled polymerization process, complex polymeric architectures with controlled molecular weight, low dispersity, as well as various functionality have been constructed, which could be applied in wide fields, including materials, biology, and electrology. Under the continuous research improvement, main achievements have focused on the development of new RAFT techniques, containing fancy initiation methods (e. Read More

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http://dx.doi.org/10.3390/polym10030318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415088PMC

Highly compressive and stretchable poly(ethylene glycol) based hydrogels synthesised using pH-responsive nanogels without free-radical chemistry.

Nanoscale 2019 Apr 9. Epub 2019 Apr 9.

School of Materials, University of Manchester, Manchester, M13 9PL, UK.

Poly(ethylene glycol) (PEG) based hydrogels are amongst the most studied synthetic hydrogels. However, reports on PEG-based hydrogels with high mechanical strength are limited. Herein, a class of novel, well-defined PEG-based nanocomposite hydrogels with tunable mechanical strength are synthesised via ring-opening reactions of diglycidyl ethers with carboxylate ions. Read More

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http://dx.doi.org/10.1039/c9nr01535cDOI Listing
April 2019
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Evaluation of colloidal platinum on cytotoxicity, oxidative stress and barrier permeability across the gut epithelium.

Heliyon 2019 Mar 21;5(3):e01336. Epub 2019 Mar 21.

Department of Biological Sciences and Cancer Systems Biology Laboratory (CanSyl), Orta Dogu Teknik Universitesi (ODTU/METU), Ankara 06800, Turkey.

Colloidal platinum (Pt) is widely consumed due to its health promoting benefits. However, the exact biological effects of these nanoparticles have not been studied in detail, particularly in the gut. In the present study we observed that colloidal Pt was not cytotoxic towards three different epithelial colon cancer cell lines. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183639
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http://dx.doi.org/10.1016/j.heliyon.2019.e01336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434063PMC
March 2019
7 Reads

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.

Cell Death Dis 2019 Apr 8;10(4):317. Epub 2019 Apr 8.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic properties, including high cell permeability, the ability to easily cross both the blood-brain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field. Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players. Read More

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http://dx.doi.org/10.1038/s41419-019-1556-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453953PMC

Radical Scavenging Activities of Novel Cationic Inulin Derivatives.

Polymers (Basel) 2018 Nov 22;10(12). Epub 2018 Nov 22.

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

Many saccharides are attractive targets for biomaterial applications, due to their abundance, biocompatibility, and biodegradability. In this article, a synthesis process of 6--substituted cationic inulin derivatives, including 6-pyridyl-6-deoxyinulin bromide (PIL), 6-(2-amino-pyridyl)-6-deoxyinulin bromide (2APIL), 6-(3-amino-pyridyl)-6-deoxyinulin bromide (3APIL), 6-(4-amino-pyridyl)-6-deoxyinulin bromide (4APIL), 6-(2,3-diamino-pyridyl)-6-deoxyinulin bromide (2,3DAPIL), 6-(3,4-diamino-pyridyl)-6-deoxyinulin bromide (3,4DAPIL), and 6-(2,6-diamino-pyridyl)-6-deoxyinulin bromide (2,6DAPIL) was described. The C₆-OH of inulin was first activated by PPh₃/N-bromosuccinimide (NBS) bromination. Read More

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http://dx.doi.org/10.3390/polym10121295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401882PMC
November 2018

Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization-A Surface with Application Potential in Biomaterials.

Polymers (Basel) 2018 Oct 18;10(10). Epub 2018 Oct 18.

Institute of Chemistry, University of Potsdam, D-14476 Potsdam, Germany.

This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Read More

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http://dx.doi.org/10.3390/polym10101165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403983PMC
October 2018

Antioxidant and Anti-Diabetic Activities of Polysaccharides from Guava Leaves.

Molecules 2019 Apr 5;24(7). Epub 2019 Apr 5.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.

Guava ( L., Myrtaceae) leaves have been used as a folk herbal tea to treat diabetes for a long time in Asia and North America. In this study, we isolated polysaccharides from guava leaves (GLP), and evaluated its antioxidant activity in vitro and anti-diabetic effects on diabetic mice induced by streptozotocin combined with high-fat diet. Read More

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http://dx.doi.org/10.3390/molecules24071343DOI Listing

Effects of quercetin on microRNAs: A mechanistic review.

J Cell Biochem 2019 Apr 7. Epub 2019 Apr 7.

Department of Clinical Biochemistry-Biophysics and Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

MicroRNA (miRNA)-dependent pathways are one of the newest gene regulation mechanisms in various diseases, particularly in cancers. miRNAs are endogenous noncoding RNAs with about 18 to 25 nucleotide length, which can regulate the expression of at least 60% of human total genome posttranscriptionally. Quercetin is the most abundant flavonoid in a variety of fruits, flowers, and medical herbs, known as a strong free radical scavenger that could show antioxidant, anti-inflammatory, and antitumor activities. Read More

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http://dx.doi.org/10.1002/jcb.28663DOI Listing

Development of low molecular weight heparin by HO/ascorbic acid with ultrasonic power and its anti-metastasis property.

Int J Biol Macromol 2019 Apr 4. Epub 2019 Apr 4.

Zhejiang Key Laboratory for Agro-Food Processing, Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Low molecular weight heparins (LMWHs) are currently used as an anticoagulant agent since unfractionated heparin (UFH) can cause serious adverse drug reactions. LMWHs are commercially prepared using different methods such as nitrous acid cleavage and β-elimination under strong reaction conditions or with harsh chemicals, which may cause the saccharide units within the polysaccharide backbone to be decomposed and noticeably modified. This study demonstrates an effective method for depolymerizing heparin via the production of large amounts of free radicals from HO/ascorbic acid and ultrasonic power; this results in highly pure products because ascorbic acid can decompose during the reaction, which is different from the previously reported HO/Cu method. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.019DOI Listing

Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 4. Epub 2019 Apr 4.

Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India. Electronic address:

Loss of E-cadherin and epithelial to mesenchymal transition (EMT) are key steps in cancer progression. Reactive oxygen species (ROS) play significant roles in cellular physiology and homeostasis. Roles of E-cadherin, EMT and ROS are intriguingly illustrated in many cancers without focusing their collective concert during cancer progression. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.04.002DOI Listing
April 2019
1 Read

The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes.

Anat Sci Int 2019 Apr 4. Epub 2019 Apr 4.

Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, 262, Gamcheon-ro, Seo-gu, Busan, 49267, Korea.

Oxidative stress contributes to the progression of neurodegenerative diseases of the central and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke, and diabetic neuropathy. Despite the greater capability of peripheral nerves to regenerate compared with those in the brain or spinal cord, chronic oxidative stress leads to irreversible neurodegeneration in peripheral nerves. Thus, many efforts have been made to defend against irreversible peripheral nerve degeneration and oxidative stress. Read More

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http://dx.doi.org/10.1007/s12565-019-00486-2DOI Listing
April 2019
4 Reads

Redox Systems Biology of Nutrition and Oxidative Stress.

J Nutr 2019 Apr;149(4):553-565

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA.

Diet and nutrition contribute to both beneficial and harmful aspects of oxidative processes. The harmful processes, termed oxidative stress, occur with many human diseases. Major advances in understanding oxidative stress and nutrition have occurred with broad characterization of dietary oxidants and antioxidants, and with mechanistic studies showing antioxidant efficacy. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy306DOI Listing
April 2019
8 Reads

Induction of isoflavonoid biosynthesis in Lotus japonicus after UV-B irradiation.

J Plant Physiol 2019 Mar 23;236:88-95. Epub 2019 Mar 23.

Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik Unversity in Košice, Mánesova 23, SK-04001, Košice, Slovakia. Electronic address:

Enhanced ultraviolet radiation (UV) is an important environmental factor that may cause reductions in the growth and productivity of plants. In the present work we studied the response to UV-B radiation in leaves of the model legume Lotus japonicus. After UV-B treatment, induction of phenyalanine-ammonia lyase gene expression and enzyme activity was detected. Read More

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http://dx.doi.org/10.1016/j.jplph.2019.03.003DOI Listing
March 2019
1 Read

Hepatocyte-Specific Ablation or Whole Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.

Diabetes 2019 Apr 1. Epub 2019 Apr 1.

Department of Physiology and Pharmacology; West Virginia University, Health Sciences Center, Morgantown, WV

Systemic hyperuricemia (HyUA) in obesity/T2DM facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Here, the effects of hepatocyte-specific ablation of , the gene encoding XOR (HXO) and whole-body pharmacologic inhibition of XOR (febuxostat) on obesity-induced insulin resistance/dyslipidemia were assessed. Deletion of hepatocyte substantially lowered liver and plasma UA concentration. Read More

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http://dx.doi.org/10.2337/db18-1198DOI Listing
April 2019
2 Reads

TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

Cell Physiol Biochem 2019 ;52(4):742-757

Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada,

Background/aims: The oxidative stress sensor transient receptor potential melastatin-2 (TRPM2) ion channel has recently gained attention in many types of cancer. The lung tissue is highly susceptible to oxidative stress-mediated injury and diseases; therefore, we aimed to determine whether TRPM2 plays an essential role in protecting lung cancer cells from oxidative damage while promoting cancer cell survival and metastasis.

Methods: We used two non-small cell lung (NSCLC) cell lines A549 and H1299 as a lung cancer model. Read More

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http://dx.doi.org/10.33594/000000052DOI Listing
April 2019
1 Read

Ternary thiol-ene photopolymerization for facile preparation of ionic liquid-functionalized hybrid monolithic columns based on polyhedral oligomeric silsesquioxanes.

J Chromatogr A 2019 Mar 22. Epub 2019 Mar 22.

Key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education & Fujian Province), College of Chemistry, Fuzhou University, Fuzhou 350108, P.R. China. Electronic address:

A simple thiol-ene photopolymerization approach was developed for the rapid preparation of ionic liquid-functionalized hybrid monolithic column based on polyhedral oligomeric silsesquioxane (POSS). "One-pot" polymerization was realized in the UV-transparent fused-silica capillary by using octanethiol, 1-allyl-3-methylimidazolium hexafluorophosphate as functional monomers and methacryl-substituted POSS as a crosslinker. The thiol-vinyl-methacrylate ternary system uniquely exhibits a mixed step-chain growth polymerization regime that combining the thiol-ene reaction and free-radical reaction mechanisms, which provides a simple route to prepare novel POSS-based functionalized hybrid monoliths. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219673193028
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http://dx.doi.org/10.1016/j.chroma.2019.03.032DOI Listing
March 2019
7 Reads

Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.

Eur Urol Oncol 2019 Feb 5;2(1):1-11. Epub 2018 Sep 5.

Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK; Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK. Electronic address:

Background: The prostate cancer (PCa) diagnostic pathway is undergoing a radical change with the introduction of multiparametric magnetic resonance imaging (mpMRI), genomic testing, and different prostate biopsy techniques. It has been proposed that these tests should be used in a sequential manner to optimise risk stratification.

Objective: To characterise the genomic, epigenomic, and transcriptomic features of mpMRI-visible and -nonvisible PCa in clinically localised disease. Read More

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http://dx.doi.org/10.1016/j.euo.2018.08.005DOI Listing
February 2019
1 Read

Preconditioning the rat heart with sodium thiosulfate preserved the mitochondria in response to ischemia-reperfusion injury.

J Bioenerg Biomembr 2019 Mar 30. Epub 2019 Mar 30.

Vascular Biology Lab, SASTRA-Deemed University, Thanjavur, Tamilnadu, 613401, India.

Sodium thiosulfate preconditioning (SIPC) was recently reported to be cardioprotective due to its ability to inhibit caspase-3 activation, chelate calcium ions and scavenge free radicals. However, the rationale behind its ability to improve the contractility of isolated rat heart challenged with ischemia-reperfusion injury (IR) is not well understood. As mitochondrial preservation is implicated in cardioprotection against IR, the present study was conceived to identify whether the cardioprotective effects of SIPC is associated with mitochondrial preservation. Read More

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http://dx.doi.org/10.1007/s10863-019-09794-8DOI Listing

Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.

Eur J Med Chem 2019 Mar 21;171:420-433. Epub 2019 Mar 21.

Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:

(E)-3,4-dihydroxystyryl alkyl sulfones, as new analogues of neurodegenerative agents, were designed and synthesized. The biological results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as HO, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, 6. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.044DOI Listing
March 2019
1 Read

"Redox lipidomics technology: Looking for a needle in a haystack".

Chem Phys Lipids 2019 Mar 27;221:93-107. Epub 2019 Mar 27.

Department of Environmental and Occupational Health, Pittsburgh, PA, USA; Pharmacology and Chemical Biology, Pittsburgh, PA, USA; Radiation Oncology, Pittsburgh, PA, USA; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA; Laboratory of Navigational Redox Lipidomics, IM Sechenov Moscow State Medical University, Moscow, Russia. Electronic address:

Aerobic life is based on numerous metabolic oxidation reactions as well as biosynthesis of oxygenated signaling compounds. Among the latter are the myriads of oxygenated lipids including a well-studied group of polyunsaturated fatty acids (PUFA) - octadecanoids, eicosanoids, and docosanoids. During the last two decades, remarkable progress in liquid-chromatography-mass spectrometry has led to significant progress in the characterization of oxygenated PUFA-containing phospholipids, thus designating the emergence of a new field of lipidomics, redox lipidomics. Read More

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http://dx.doi.org/10.1016/j.chemphyslip.2019.03.012DOI Listing
March 2019
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2.422 Impact Factor

Rapeseed flower pollen bio-green synthesized silver nanoparticles: a promising antioxidant, anticancer and antiangiogenic compound.

J Biol Inorg Chem 2019 Mar 29. Epub 2019 Mar 29.

Department of Biology, Islamic Azad University, Mashhad Branch, Mashhad, Iran.

Based on recent researches, bio synthesized silver nanoparticles (Ag-NPs) seem to have the potential in declining angiogenesis and oxidative stress. In the current study, rapeseed flower pollen (RFP) water extract was triggered to synthesize RFP-silver nanoparticles (RFP/Ag-NPs). Moreover, antioxidant, antiangiogenesis and cytotoxicity of the RFP/Ag-NPs against MDA-MB-231, MCF7 and carcinoma cell lines and normal human skin fibroblast HDF were compared. Read More

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http://dx.doi.org/10.1007/s00775-019-01655-4DOI Listing

Synthesis of superabsorbent polymers based on chitosan derivative graft acrylic acid-co-acrylamide and its property testing.

Int J Biol Macromol 2019 Mar 26;132:575-584. Epub 2019 Mar 26.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address:

A new kind of eco-friendly superabsorbent polymer was successfully synthesized using (2-pyridyl) acetyl chitosan chloride (PACS), acrylic acid (AA) and acrylamide (AM) in aqueous solution by a free radical polymerization. The effect of different reaction conditions, such as the initiator content, crosslinker content and PACS content were investigated. And the water retention, salt tolerance and reuse ability were investigated too. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.176DOI Listing
March 2019
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Zero-valent silver nanoparticles attenuate Cd and Pb toxicities on Moringa oleifera via immobilization and induction of phytochemicals.

Plant Physiol Biochem 2019 Mar 22;139:283-292. Epub 2019 Mar 22.

Department of Pure and Applied Chemistry, Osun State University, Osogbo, Nigeria.

Potentials of zero-valent extract of cocoa pod mediated silver nanoparticles (AgNPs) for heavy metals (cadmium and lead) immobilization, attenuation of induced toxicities and influence on phytochemical contents in Moringa oleifera were investigated. M. oleifera seeds were planted in soil spiked and watered with water (control), 0. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.03.030DOI Listing

Multidirectional insights into the biochemical and toxicological properties of Bougainvillea glabra (Choisy.) aerial parts: A functional approach for bioactive compounds.

J Pharm Biomed Anal 2019 Mar 16;170:132-138. Epub 2019 Mar 16.

School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia; Tropical Medicine and Biology Multidisciplinary Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia; Global Asia in The 21st Century (GA21) Multidisciplinary Research Platform, Monash University, Malaysia. Electronic address:

The current research work was conducted in order to probe into the biochemical and toxicological characterisation of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (Choisy.) aerial parts. Biological fingerprints were assessed for in vitro antioxidant, key enzyme inhibitory and cytotoxicity potential. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.027DOI Listing
March 2019
2.979 Impact Factor

Correlation between Children's eating behaviors and caregivers' feeding behaviors among preschool children in China.

Appetite 2019 Mar 24;138:146-152. Epub 2019 Mar 24.

Department of Health Statistics, Shaanxi Key Laboratory of Free Radical Biology and Medicine and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University of PLA, Changle West Road 169#, Xi'an, Shaanxi, 710032, China. Electronic address:

The aim of this study was to explore the relationship between caregivers' feeding behaviors and children's eating behaviors among preschoolers in China. From April to July 2016, a cross-sectional survey was administered to 912 preschoolers' caregivers in China. The Chinese Preschooler's Caregiver Feeding Behavior Scale (CPCFBS) and Chinese Preschooler's Eating Behavior Questionnaire (CPEBQ) were used to assess caregivers' feeding behaviors and children's eating behaviors, respectively. Read More

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http://dx.doi.org/10.1016/j.appet.2019.03.022DOI Listing

Development of near-infrared region luminescent N-acetyl-L-cysteine-coated AgS quantum dots with differential therapeutic effect.

Nanomedicine (Lond) 2019 Apr 27;14(8):969-987. Epub 2019 Mar 27.

Department of Chemistry, Koc University, Istanbul 34450, Turkey.

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated AgS (NAC-AgS) quantum dot (QD) as an optical imaging and therapeutic agent.

Materials & Methods: QDs were synthesized in water. Read More

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http://dx.doi.org/10.2217/nnm-2018-0214DOI Listing
April 2019
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EMT Markers in Locally-Advanced Prostate Cancer: Predicting Recurrence?

Front Oncol 2019 11;9:131. Epub 2019 Mar 11.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Prostate cancer (PCa) is the second most frequent cause of cancer-related death in men worldwide. It is a heterogeneous disease at molecular and clinical levels which makes its prognosis and treatment outcome hard to predict. The epithelial-to-mesenchymal transition (EMT) marks a key step in the invasion and malignant progression of PCa. Read More

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http://dx.doi.org/10.3389/fonc.2019.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421270PMC

Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue.

Environ Sci Pollut Res Int 2019 Mar 25. Epub 2019 Mar 25.

Radiation Biology Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), 3 street (3st) Ahmed Elzomer, P.O. Box 29, Nasr City, Cairo, Egypt.

Radiation-induced brain injury is common and mainly occurs in patients receiving radiotherapy for malignant head and neck tumors. The brain is oversensitive to oxidant injury induced by radiation. Biotin is a member of the vitamin B complex family and its deficiency has been associated with neurogenesis impairment in animals and humans. Read More

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http://dx.doi.org/10.1007/s11356-019-04806-xDOI Listing
March 2019
3 Reads

The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network.

Oxid Med Cell Longev 2019 18;2019:9706792. Epub 2019 Feb 18.

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, School of Chemistry, Central China Normal University, Wuhan, 430079 Hubei, China.

Multiple signaling pathways including ERK, PI3K-Akt, and NF-B, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of HO provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O into HO. Here, tests performed by the utilization of our designed specific SOD1 inhibitor LD100 on cancer and normal cells reveal that the signaling pathways and their crosstalk to support cancer cell growth are repressed, but the signaling pathways to promote cancer cell cycle arrest and apoptosis are stimulated by specific SOD1 inhibition-mediated ROS changes. These regulated pathways constitute an ROS signaling network that determines the fate of cancer cells. Read More

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http://dx.doi.org/10.1155/2019/9706792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398008PMC

Sulfide (Na₂S) and Polysulfide (Na₂S₂) Interacting with Doxycycline Produce/Scavenge Superoxide and Hydroxyl Radicals and Induce/Inhibit DNA Cleavage.

Molecules 2019 Mar 22;24(6). Epub 2019 Mar 22.

Institute of Clinical and Translational Research, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.

Doxycycline (DOXY) is an antibiotic routinely prescribed in human and veterinary medicine for antibacterial treatment, but it has also numerous side effects that include oxidative stress, inflammation, cancer or hypoxia-induced injury. Endogenously produced hydrogen sulfide (H₂S) and polysulfides affect similar biological processes, in which reactive oxygen species (ROS) play a role. Herein, we have studied the interaction of DOXY with H₂S (Na₂S) or polysulfides (Na₂S₂, Na₂S₃ and Na₂S₄) to gain insights into the biological effects of intermediates/products that they generate. Read More

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http://dx.doi.org/10.3390/molecules24061148DOI Listing

High-performance liquid chromatographic analysis explores the potential antioxidative agents of ARN. EX CHOISY extract.

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):16-22

Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research, Dhaka 1205, Bangladesh.

Background: Antioxidative properties of medicinal plants play the key role in plant defense mechanism. is an evergreen shrub which is used in the treatment of boils, gastric ulcers, tumor, marasmus, paralysis and spermatorrhea, rheumatoid arthritis, cold, painful sensation, and fever.

Aims: This research investigates the phytochemical contents and antioxidative effects of optimized crude methanol extract of . Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_252_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394157PMC
March 2019
1 Read

Hemoglobin β93 Cysteine is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.

Circulation 2019 Mar 25. Epub 2019 Mar 25.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Background: Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β-chain (β93C) to form S-nitroso hemoglobin (SNO-Hb) is claimed to be essential for export of NO bioactivity by the red blood cell (RBC) to mediate hypoxic vasodilation and cardioprotection.

Methods: To test this hypothesis we used RBCs from mice where the β93 cysteine had been replaced with alanine (β93A) in a number of ex vivo and in vivo models suitable for studying export of NO bioactivity.

Results: In an ex vivo model of cardiac ischemia reperfusion (IR) injury, perfusion of a mouse heart with control RBCs (β93C) pre-treated with an arginase inhibitor to facilitate export of RBC NO bioactivity, improved cardiac recovery after IR injury and the response was similar with β93A RBCs. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039284DOI Listing

Mixed adenoneuroendocrine carcinoma of the urethra.

BMJ Case Rep 2019 Mar 21;12(3). Epub 2019 Mar 21.

Department of Urology, Royal Free London NHS Foundation Trust, London, UK.

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour found predominantly in the gastrointestinal tract. Comprising adenocarcinomatous and neuroendocrine components, MANEC have been reported in the bladder. We report the first case to our knowledge of a MANEC arising in the urethra. Read More

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http://dx.doi.org/10.1136/bcr-2018-227948DOI Listing
March 2019
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Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells.

Food Chem 2019 Aug 6;288:306-314. Epub 2019 Mar 6.

Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland. Electronic address:

Health benefits are routinely attributed to whey proteins, their hydrolysates and peptides based on in vitro chemical and cellular assays. The objective of this study was to track the fate of whey proteins through the upper gastrointestinal tract, their uptake across the intestinal barrier and then assess the physiological impact to downstream target cells. Simulated gastrointestinal digestion (SGID) released a selection of whey peptides some of which were transported across a Caco-2/HT-29 intestinal barrier, inhibited free radical formation in muscle and liver cells. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.03.009DOI Listing

The glutathione system and the related thiol network in Caenorhabditis elegans.

Redox Biol 2019 Mar 16;24:101171. Epub 2019 Mar 16.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia. Electronic address:

Advances in the field of redox biology have contributed to the understanding of the complexity of the thiol-based system in mediating signal transduction. The redox environment is the overall spatiotemporal balance of oxidation-reduction systems within the integrated compartments of the cell, tissues and whole organisms. The ratio of the reduced to disulfide glutathione redox couple (GSH:GSSG) is a key indicator of the redox environment and its associated cellular health. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429583PMC

Molecular suitability of the chacma baboon in human-targeted Von Willebrand factor directed studies.

J Med Primatol 2019 Mar 20. Epub 2019 Mar 20.

Human Molecular Biology Unit, Faculty of Health Sciences, School of Biomedical Sciences, University of the Free State, Bloemfontein, South Africa.

Background: Von Willebrand factor (VWF) has a central role in primary haemostasis and is a popular pharmaceutical target in the prevention and treatment of disorders such as acute coronary syndrome and thrombotic thrombocytopenic purpura. We have evaluated numerous possible treatments targeting VWF in the chacma baboon. Unfortunately, no data exist regarding the molecular similarity of the chacma baboon and human VWF protein, resulting in limited translatability of results. Read More

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http://dx.doi.org/10.1111/jmp.12407DOI Listing
March 2019
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Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells.

Mol Cell Biochem 2019 Mar 20. Epub 2019 Mar 20.

Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC, V6T 1Z4, Canada.

Chlorogenic acid (CGA) exists as multiple isomers (e.g., 3-CQA, 4-CQA, 5-CQA, 3,4-diCQA, 3,5-diCQA, and 4,5-diCQA) in foods such as coffee beverages, fruits and vegetables. Read More

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http://dx.doi.org/10.1007/s11010-019-03516-9DOI Listing