30,472 results match your criteria Free Radical Biology & Medicine[Journal]


Renal iron accumulation and oxidative injury with aging: effects of treatment with an iron chelator.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Health and Human Physiology, The University of Iowa.

Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 mo) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4. Read More

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http://dx.doi.org/10.1093/gerona/glz055DOI Listing
February 2019

Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Biomed Pharmacother 2019 Feb 19;112:108643. Epub 2019 Feb 19.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.

Biologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108643DOI Listing
February 2019

Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach.

Front Cell Infect Microbiol 2019 4;9:15. Epub 2019 Feb 4.

National Centre for Cell Science, Pune, India.

Leishmania parasites possess an exceptional oxidant and chemical defense mechanism, involving a very unique small molecular weight thiol, trypanothione (T[SH]), that helps the parasite to manage its survival inside the host macrophage. The reduced state of T[SH] is maintained by NADPH-dependent trypanothione reductase (TryR) by recycling trypanothione disulfide (TS). Along with its most important role as central reductant, T[SH] have also been assumed to regulate the activation of iron-sulfur cluster proteins (Fe/S). Read More

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http://dx.doi.org/10.3389/fcimb.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369582PMC
February 2019

Metal-Free Catalytic Synthesis of Thiocarbamates Using Sodium Sulfinates as the Sulfur Source.

J Org Chem 2019 Feb 18. Epub 2019 Feb 18.

School of Chemistry and Chemical Engineering , Qufu Normal University , Qufu 273165 , Shandong , China.

A novel molecular iodine-catalyzed protocol for the construction of thiocarbamates from readily available sodium sulfinates, isocyanides, and water has been described. The present methodology offers a facile and practical route to a variety of thiocarbamates in moderate to good yields with favorable functional group tolerance by use odorless sodium sulfinates as the sulfur source. The mechanistic studies suggest the present transformation involves a radical process. Read More

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http://dx.doi.org/10.1021/acs.joc.8b02844DOI Listing
February 2019

Cerium Oxide Nanoparticles Protect Cyclophosphamide-induced Testicular Toxicity in Mice.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Cyclophosphamide (CP), as a chemotherapy drug, causes severe damage in testicular tissue through producing free radicals. Cerium oxide nanoparticles (NC) exhibit antioxidant and anti-inflammatory properties. The purpose of this study was to investigate the protective effect of NC on CP-induced testicular damage in mice. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_184_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360849PMC
January 2019

Non-Toxic and Ultra-Small Biosilver Nanoclusters Trigger Apoptotic Cell Death in Fluconazole-Resistant via Ras Signaling.

Biomolecules 2019 Jan 29;9(2). Epub 2019 Jan 29.

Herbal Nanobiotechnology Lab, Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India.

Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated. Here, we biosynthesize nontoxic and ultra-small silver nanoclusters (rsAg@NCs) using metabolites of usnioid lichen (a symbiotic association of algae and fungi) that exhibit excellent antimicrobial activity against fluconazole (FCZ)-resistant that is many times higher than chemically synthesized silver nanoparticles (AgNPs) and FCZ. The rsAg@NCs trigger apoptosis via reactive oxygen species accumulation that leads to the loss of mitochondrial membrane potential, DNA fragmentation, chromosomal condensation, and the activation of metacaspases. Read More

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http://dx.doi.org/10.3390/biom9020047DOI Listing
January 2019
1 Read

In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium.

Mol Biol Rep 2019 Feb 14. Epub 2019 Feb 14.

Agronomy and Plant Breeding Department, Razi University, Kermanshah, Iran.

Hypericum lydium Boiss. is a perennial plant of the Hypericaceae family, which has been used in particular to treat depression. The aim of this study was to determine in vitro antioxidant, antimicrobial activities, anticholinesterase (acetylcholinesterase (AChE)/butyrylcholinesterase (BChE)), antidiabetic activities (α-glucosidase/α-amylase) and Tyrosinase inhibitor activity of methanol and water extracts of H. Read More

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http://dx.doi.org/10.1007/s11033-019-04664-3DOI Listing
February 2019
1 Read

Impact of Nitric Oxide (NO) on the ROS Metabolism of Peroxisomes.

Plants (Basel) 2019 Feb 10;8(2). Epub 2019 Feb 10.

Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Profesor Albareda 1, 18008 Granada, Spain.

Nitric oxide (NO) is a gaseous free radical endogenously generated in plant cells. Peroxisomes are cell organelles characterized by an active metabolism of reactive oxygen species (ROS) and are also one of the main cellular sites of NO production in higher plants. In this mini-review, an updated and comprehensive overview is presented of the evidence available demonstrating that plant peroxisomes have the capacity to generate NO, and how this molecule and its derived products, peroxynitrite (ONOO⁻) and -nitrosoglutathione (GSNO), can modulate the ROS metabolism of peroxisomes, mainly throughout protein posttranslational modifications (PTMs), including -nitrosation and tyrosine nitration. Read More

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http://dx.doi.org/10.3390/plants8020037DOI Listing
February 2019

Total Phenols from Grape Leaves Counteract Cell Proliferation and Modulate Apoptosis-Related Gene Expression in MCF-7 and HepG2 Human Cancer Cell Lines.

Molecules 2019 Feb 10;24(3). Epub 2019 Feb 10.

Institute of Sciences of Food Production, National Research Council, Traversa la Crucca, 3. Loc Baldinca Li Punti, 07100 Sassari, Italy.

Grape leaves influence several biological activities in the cardiovascular system, acting as antioxidants. In this study, we aimed at evaluating the effect of ethanolic and water extracts from grape leaves grown in Algeria, obtained by accelerator solvent extraction (ASE), on cell proliferation. The amount of total phenols was determined using the modified Folin-Ciocalteu method, antioxidant activities were evaluated by the 2,2-diphenyl-l-picrylhydrazyl free radical (DPPH*) method and OH radical scavenging using electron paramagnetic resonance (EPR) spectroscopy methods. Read More

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http://dx.doi.org/10.3390/molecules24030612DOI Listing
February 2019

Genome sequencing and traits analysis of Burkholderia strains reveal a promising biocontrol effect against grey mould disease in grapevine (Vitis vinifera L.).

World J Microbiol Biotechnol 2019 Feb 9;35(3):40. Epub 2019 Feb 9.

Unité de Recherche Résistance Induite et BioProtection des Plantes, UFR Sciences Exactes et Naturelles, SFR Condorcet FR CNRS 3417, Université de Reims-Champagne-Ardenne, 51687, Reims Cedex 2, France.

Grey mould caused by Botrytis cinerea is among the most important disease affecting the production of grapevine worldwide. The high economical loss each year has led producers to become more dependent on chemical pesticides for protection. However, environmental impacts of the pesticides overuse have sparked crescent interest in developing alternative biocontrol methods. Read More

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http://dx.doi.org/10.1007/s11274-019-2613-1DOI Listing
February 2019

Interaction of methyl viologen-induced chloroplast and mitochondrial signalling in Arabidopsis.

Free Radic Biol Med 2019 Feb 6;134:555-566. Epub 2019 Feb 6.

Organismal and Evolutionary Biology Research Program, Faculty of Biological and Environmental Sciences, Viikki Plant Science Centre, University of Helsinki, P.O Box 65 (Viikinkaari 1), FI-00014, Helsinki, Finland. Electronic address:

Reactive oxygen species (ROS) are key signalling intermediates in plant metabolism, defence, and stress adaptation. In plants, both the chloroplast and mitochondria are centres of metabolic control and ROS production, which coordinate stress responses in other cell compartments. The herbicide and experimental tool, methyl viologen (MV) induces ROS generation in the chloroplast under illumination, but is also toxic in non-photosynthetic organisms. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.006DOI Listing
February 2019
1 Read

Hypofractionated Radiotherapy in Oesophageal Cancer for Patients Unfit for Systemic Therapy: A Retrospective Single-Centre Analysis.

Clin Oncol (R Coll Radiol) 2019 Feb 5. Epub 2019 Feb 5.

Radiotherapy Research Group, Leeds Cancer Centre, The Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

Aims: Chemoradiotherapy (CRT) is established as a superior treatment option to definitive radiotherapy in the non-surgical management of oesophageal cancer. For patients precluded from CRT through choice or comorbidity there is little evidence to guide delivery of single-modality radiotherapy. In this study we outline outcomes for patients unfit for CRT who received a hypofractionated radiotherapy (HRT) regimen. Read More

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http://dx.doi.org/10.1016/j.clon.2019.01.010DOI Listing
February 2019

Melatonin: A Small Molecule but Important for Salt Stress Tolerance in Plants.

Int J Mol Sci 2019 Feb 7;20(3). Epub 2019 Feb 7.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Agronomy and Yangling Branch of China Wheat Improvement Center, Northwest A&F University, Yangling 712100, China.

Salt stress is one of the most serious limiting factors in worldwide agricultural production, resulting in huge annual yield loss. Since 1995, melatonin (-acetyl-5-methoxytryptamine)-an ancient multi-functional molecule in eukaryotes and prokaryotes-has been extensively validated as a regulator of plant growth and development, as well as various stress responses, especially its crucial role in plant salt tolerance. Salt stress and exogenous melatonin lead to an increase in endogenous melatonin levels, partly via the phyto-melatonin receptor CAND2/PMTR1. Read More

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http://dx.doi.org/10.3390/ijms20030709DOI Listing
February 2019

A Strong Impact of Soil Tetracycline on Physiology and Biochemistry of Pea Seedlings.

Scientifica (Cairo) 2019 10;2019:3164706. Epub 2019 Jan 10.

Department of Plant Physiology, Genetics and Biotechnology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718 Olsztyn, Poland.

Antibiotics are a new type of contaminants found in the environment. They are increasingly used in farm animal production systems and may accumulate in crops, limiting the plant growth rate and nutritive value. The aim of this study was to determine the effects of tetracycline (TC) on physiological and biochemical properties of pea seedlings. Read More

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https://www.hindawi.com/journals/scientifica/2019/3164706/
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http://dx.doi.org/10.1155/2019/3164706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348853PMC
January 2019
3 Reads

Ultrasound-assisted fast preparation of low molecular weight fucosylated chondroitin sulfate with antitumor activity.

Carbohydr Polym 2019 Apr 21;209:82-91. Epub 2018 Dec 21.

Zhejiang Key Laboratory for Agro-Food Processing, Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Fucosylated chondroitin sulfate from sea cucumber Isostichopus badionotus (fCS-Ib) was depolymerized with an ultrasound-accelerated, metal-free Fenton chemistry, relying on HO/ascorbic acid redox system. Fragments of different molecular weights were obtained at different reaction temperatures, ascorbic acid concentrations and ultrasonic intensities. The structures of two typical depolymerized fragments were evaluated using high-performance liquid chromatography (HPLC), infrared spectroscopy (IR), and nuclear magnetic resonance spectroscopy (NMR). Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.12.061DOI Listing

Antioxidants: Scientific Literature Landscape Analysis.

Oxid Med Cell Longev 2019 8;2019:8278454. Epub 2019 Jan 8.

The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, 05-552 Magdalenka, Poland.

Antioxidants are abundant in natural dietary sources, and the consumption of antioxidants has a lot of potential health benefits. However, there has been no literature analysis on this topic to evaluate its scientific impact in terms of citations. This study is aimed at identifying and analysing the antioxidant publications in the existing scientific literature. Read More

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http://dx.doi.org/10.1155/2019/8278454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341248PMC
January 2019
1 Read

Pathological profiles and clinical management challenges of breast cancer emerging in young women in Indonesia: a hospital-based study.

BMC Womens Health 2019 Feb 6;19(1):28. Epub 2019 Feb 6.

PILAR Research and Education, 20 Station Road, Cambridge, CB1 2JD, UK.

Background: Breast cancer diagnosed at a young age is often associated with aggressive biology, advanced stage, and unfavorable prognosis. The median age of breast cancer diagnosis in Indonesia is younger (48 vs. 68 years-old in Europe) with a relatively higher proportion of patients younger than 40 years old. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0724-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364389PMC
February 2019
2 Reads
1.657 Impact Factor

Structure-antioxidant capacity relationship of dihydrochalcone compounds in Malus.

Food Chem 2019 Mar 24;275:354-360. Epub 2018 Sep 24.

State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, Shaanxi 712100, China.

The antioxidant capacity (AC) of six dihydrochalcone compounds was evaluated using DPPH and ABTS assays. In water-based solution 3-hydroxyphlorizin exhibited the highest AC among all dihydrochalcones. In acetone and acidic solutions (pH = 2. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.09.135DOI Listing

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence.

Basic Clin Neurosci 2018 Sep-Oct;9(5):317-324. Epub 2018 Sep 1.

Department of Medicinal Plants, School of Science and Herbs, Amol University of Special Modern Technologies, Amol, Iran.

Introduction: Studies have suggested that free radicals-induced neurodegeneration is one of the many studies of Parkinson Disease (PD). Quercetin as a natural polyphenol has been regarded as a significant player in altering the progression of neurodegenerative diseases by protecting from damages caused by free radicals. Owing to its poor water solubility, preparation of its oral formulation is urgently needed. Read More

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http://dx.doi.org/10.32598/bcn.9.5.317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360495PMC
September 2018
1 Read

The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.

J Biol Chem 2019 Feb 4. Epub 2019 Feb 4.

Orthopedic Surgery, Maastricht University Medical Center, Netherlands.

Viperin (also known as radical SAM domain-containing 2, RSAD2) is an interferon-inducible and evolutionary conserved protein that participates in the cell's innate immune response against a number of viruses. Viperin mRNA is a substrate for endoribonucleolytic cleavage by RNase mitochondrial RNA processing (MRP) and mutations in the RMRP small nucleolar RNA (snoRNA) subunit of the RNase MRP complex cause cartilage-hair hypoplasia (CHH), a human developmental condition characterized by metaphyseal chondrodysplasia and severe dwarfism. It is unknown how CHH-pathogenic mutations in RMRP snoRNA interfere with skeletal development and aberrant processing of RNase MRP substrate RNAs is thought to be involved. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007356DOI Listing
February 2019
2 Reads

Nitric oxide (NO) and hydrogen sulfide (H2S) in plants: Which is first?

J Exp Bot 2019 Jan 31. Epub 2019 Jan 31.

Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, C/ Profesor Albareda, Granada, Spain.

Nitric oxide (NO) is internationally regarded as a signal molecule involved in a myriad of functions in plants under physiological, pathogenic and adverse environmental conditions. Hydrogen sulfide (H2S) has also recently been recognized as a new gasotransmitter with a diverse range of functions similar to those of NO. Depending on their respective concentrations, both these molecules act synergistically or antagonistically as signals or damage promoters in plants. Read More

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http://dx.doi.org/10.1093/jxb/erz031DOI Listing
January 2019

Free radicals and redox regulation in ageing.

Free Radic Biol Med 2019 Jan 30. Epub 2019 Jan 30.

Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA, USA; Division of Molecular and Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, & Sciences, The University of Southern California, Los Angeles, CA, USA; Department of Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.041DOI Listing
January 2019

The era of nitric oxide in plant biology: Twenty years tying up loose ends.

Nitric Oxide 2019 Jan 28;85:17-27. Epub 2019 Jan 28.

Instituto de Investigaciones Biológicas. Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata - CONICET, CC 1245, 7600, Mar del Plata, Argentina. Electronic address:

Nitric oxide (NO) is an essential signal molecule to maintain cellular homeostasis in uni and pluricellular organisms. Conceptually, NO intervenes as much in sustaining basal metabolic processes, as in firing cellular responses to changes in internal and external conditions, and also in guiding the return to basal conditions. Behind these unusual capabilities of NO is the chemistry of this molecule, an unstable, reactive, free radical and short half-life gas. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.013DOI Listing
January 2019

Potential Role of H-Ferritin in Mitigating Valvular Mineralization.

Arterioscler Thromb Vasc Biol 2019 Jan 31:ATVBAHA118312191. Epub 2019 Jan 31.

From the HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian, Academy of Sciences, Debrecen (K.É.S., L.P., M.O., N.P., G.B., J.B.).

Objective- Calcific aortic valve disease is a prominent finding in elderly and in patients with chronic kidney disease. We investigated the potential role of iron metabolism in the pathogenesis of calcific aortic valve disease. Approach and Results- Cultured valvular interstitial cells of stenotic aortic valve with calcification from patients undergoing valve replacement exhibited significant susceptibility to mineralization/osteoblastic transdifferentiation in response to phosphate. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312191DOI Listing
January 2019
1 Read

Antioxidant Potential of Four Species of Natural Product and Therapeutic Strategies for Cancer through Suppression of Viability in the Human Multiple Myeloma Cell Line U266.

Biomed Environ Sci 2019 Jan;32(1):22-33

Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, University of Carthage, 1054, Tunisia.

Objective: This research aimed to evaluate the protective effects of bioactive compounds such as phenolic acids, flavonoids, and tannins present in four species extracted with methanol.

Methods: The total phenolic content of the methanolic extracts was measured spectrophotometrically. The effect of the extracts on cell viability in U266 cells was measured. Read More

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http://dx.doi.org/10.3967/bes2019.003DOI Listing
January 2019
1 Read

Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.

Free Radic Biol Med 2019 Jan 26;134:343-349. Epub 2019 Jan 26.

Division of Cardiovascular Disease, University of Alabama at Birmingham School of Medicine, USA; Birmingham Department of Veterans Affairs Medical Center, USA. Electronic address:

Background: The extra-renal effects of aldosterone on left ventricular (LV) structure and function are exacerbated by increased dietary sodium in persons with hypertension. Previous studies demonstrated endothelial dysfunction and increased oxidative stress with high salt diet in normotensive salt-resistant subjects. We hypothesized that increased xanthine oxidase (XO), a product of endothelial cells, is related to 24-h urinary sodium and to LV hypertrophy and function in patients with resistant hypertension (RHTN). Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.029DOI Listing
January 2019

RASGRP2 Suppresses Apoptosis via Inhibition of ROS Production in Vascular Endothelial Cells.

ScientificWorldJournal 2019 1;2019:4639165. Epub 2019 Jan 1.

Laboratory of Biochemistry, Hiroshima International University, Hiroshima, Japan.

We have identified () as a blood vessel related gene from Xenopus embryo. In addition, we reported that RASGRP2 is also expressed in human umbilical vein endothelial cells (HUVEC). It is known that RASGRP2 activates Ras-related protein 1 (Rap1). Read More

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https://www.hindawi.com/journals/tswj/2019/4639165/
Publisher Site
http://dx.doi.org/10.1155/2019/4639165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332872PMC
February 2019
1 Read

Mesophyll cells' ability to maintain potassium is correlated with drought tolerance in tea (Camellia sinensis).

Plant Physiol Biochem 2019 Mar 19;136:196-203. Epub 2019 Jan 19.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, China. Electronic address:

Tea plant is an important economic crop and is vulnerable to drought. A good understanding of tea drought tolerance mechanisms is required for breeding robust drought tolerant tea varieties. Previous studies showed mesophyll cells' ability to maintain K is associated with its stress tolerance. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.01.020DOI Listing
March 2019
2 Reads

Hydrogen sulfide preconditioning could ameliorate reperfusion associated injury in diabetic cardiomyopathy rat heart through preservation of mitochondria.

Biochimie 2019 Mar 22;158:208-216. Epub 2019 Jan 22.

Vascular Biology Lab, School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613401, India. Electronic address:

Evidence suggests that hydrogen sulfide precondition (HIPC) is an effective protocol in the management of ischemia reperfusion (I/R) by attenuating free radical and calcium overload in mitochondria. However the efficacy of HIPC is largely unknown in diabetic cardiomyopathy (DCM) hearts subjected to I/R procedure. Male Wistar rats were randomly divided into three groups: i) normal, ii) diabetes mellitus (DM), and iii) diabetic cardiomyopathy (DCM). Read More

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http://dx.doi.org/10.1016/j.biochi.2019.01.011DOI Listing
March 2019
1 Read

Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level.

Angew Chem Int Ed Engl 2019 Jan 24. Epub 2019 Jan 24.

Department of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.

Millions of diverse molecules constituting the lipidome act as important signals within cells. Of these, cardiolipin (CL) and phosphatidylethanolamine (PE) participate in apoptosis and ferroptosis, respectively. Their subcellular distribution is largely unknown. Read More

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http://dx.doi.org/10.1002/anie.201814256DOI Listing
January 2019

Site-directed spin labelling of proteins by Suzuki-Miyaura coupling via a genetically encoded aryliodide amino acid.

Chem Commun (Camb) 2019 Feb;55(13):1923-1926

Department of Chemistry and Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.

We report site-directed protein spin labelling via Suzuki-Miyaura coupling of a nitroxide boronic acid label with the genetically encoded amino acid 4-iodo-l-phenylalanine. The resulting spin label bears a rigid biphenyl linkage with lower flexibility than spin label R1. It is suitable to obtain defined electron paramagnetic resonance distance distributions and to report protein-membrane interactions and conformational transitions of α-synuclein. Read More

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http://dx.doi.org/10.1039/c8cc09325cDOI Listing
February 2019

A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic.

Stem Cells Dev 2019 Jan 23. Epub 2019 Jan 23.

University of Zagreb, School of Medicine, Department of Medical Biology, Zagreb, Croatia.

The spin-trap free radical scavenger N-tert-butyl-α-phenylnitron (PBN) ameliorated effects of several teratogens involving reactive oxygen species. We investigated for the first time whether PBN could ameliorate teratogenesis induced by a DNA hypomethylating hematological therapeutic 5-azacytidine (5azaC). At day 12 and 13 day of gestation Fisher rat dams were pretreated by i. Read More

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http://dx.doi.org/10.1089/scd.2018.0194DOI Listing
January 2019
1 Read

PAOT-Liquid Technology: An Easy Electrochemical Method for Evaluating Antioxidant Capacity of Wines.

Diseases 2019 Jan 21;7(1). Epub 2019 Jan 21.

Institute Européen des Antioxydants, University of Nancy, 18 rue Victor de Lespinats, 54230 Neuves-Maisons, France.

Polyphenol compounds present in high quantity in wines are well-known to have potent cardio-protective properties through several biological mechanisms including antioxidant activity [1]. A large number of methods have been developed for evaluating the antioxidant capacity of food matrices. Most of them have, however, the disadvantage of being time consuming and require specific analytical protocols and devices. Read More

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http://dx.doi.org/10.3390/diseases7010010DOI Listing
January 2019

Antipsychotic drugs scavenge radiation-induced hydroxyl radicals and intracellular ROS formation, and protect apoptosis in human lymphoma U937 cells.

Free Radic Res 2019 Feb 4:1-9. Epub 2019 Feb 4.

b Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Toyama , Japan.

Antioxidant activity has been reported for some atypical antipsychotic drugs; however, the detailed mechanism is not well known. Here, we investigated the effects of atypical antipsychotic drugs on OH radical formation, intracellular reactive oxygen species (ROS), and apoptosis induced by ionising radiation. The reaction rate constants with OH radicals were determined for five antipsychotic drugs as follows, in descending order: olanzapine, aripiprazole, clozapine, haloperidol, and risperidone. Read More

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http://dx.doi.org/10.1080/10715762.2019.1572889DOI Listing
February 2019

Mass spectrometry-based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin.

Int J Cosmet Sci 2019 Jan 20. Epub 2019 Jan 20.

Centre for Dermatology Research, Division of Musculoskeletal & Dermatological Sciences, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, and Salford Royal NHS Foundation Trust, UK.

Objective: With increasing age skin is subject to alterations in its organisation, which impacts on its function as well as having clinical consequences. Proteomics is a useful tool for non-targeted, semi-quantitative simultaneous investigation of high numbers of proteins. In the current study we utilise proteomics to characterise and contrast age-associated differences in photoexposed and photoprotected skin, with a focus on the epidermis, dermal-epidermal junction and papillary dermis. Read More

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http://doi.wiley.com/10.1111/ics.12513
Publisher Site
http://dx.doi.org/10.1111/ics.12513DOI Listing
January 2019
4 Reads

Phytomodulatory effects of silver nanoparticles on Corchorus olitorius: Its antiphytopathogenic and hepatoprotective potentials.

Plant Physiol Biochem 2019 Mar 12;136:109-117. Epub 2018 Dec 12.

Department of Pure and Applied Chemistry, Osun State University, Osogbo, Nigeria.

This study has reported the effects of biogenic silver nanoparticles (AgNPs) using cocoa pod extract on physiological tolerance indices, antioxidant activity and hepatoprotective potentials of Corchorus olitorius as well as its efficiency for controlling soil phytopathogens. C. olitorius seeds were grown in soil prepared with water (control), 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428183054
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http://dx.doi.org/10.1016/j.plaphy.2018.12.006DOI Listing
March 2019
4 Reads

Characterization of binding interactions of anthraquinones and bovine β-lactoglobulin.

Food Chem 2019 May 23;281:28-35. Epub 2018 Dec 23.

School of Medicine, Shenzhen University, Shenzhen, Guangdong Province 518060 PR China. Electronic address:

Anthraquinones, a class of naturally occurring polyphenolic compounds, exhibit a wide range of bioactivities. However, most free anthraquinones are lipophilic bioactive compounds. Bovine β-lactoglobulin (βLG), a major whey protein, has a high affinity for small hydrophobic compounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03088146183218
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http://dx.doi.org/10.1016/j.foodchem.2018.12.077DOI Listing
May 2019
4 Reads

Limited oxidative stress in common carp (Cyprinus carpio, L., 1758) exposed to a sublethal tertiary (Cu, Cd and Zn) metal mixture.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 15;218:70-80. Epub 2019 Jan 15.

Systemic Physiological and Ecotoxicological Research, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.

Analyzing effects of metal mixtures is important to obtain a realistic understanding of the impact of mixed stress in natural ecosystems. The impact of a one-week exposure to a sublethal metal mixture containing copper (4.8 μg/L), cadmium (2. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.01.003DOI Listing
April 2019
1 Read

Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme.

Free Radic Biol Med 2019 Jan 15;134:215-228. Epub 2019 Jan 15.

Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK. Electronic address:

Microbes can have multiple enzymes that are able to catalyse the same enzymatic reactions but may differ in structure. These are known as isozymes. It is assumed that isozymes have the same functional role for cells. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.018DOI Listing
January 2019
1 Read

N-acetylcysteine addition after vitrification improves oocyte mitochondrial polarization status and the quality of embryos derived from vitrified murine oocytes.

BMC Vet Res 2019 Jan 17;15(1):31. Epub 2019 Jan 17.

Jesús Usón Minimally Invasive Surgery Centre, Carretera N-521, km. 41,8, 10071, Cáceres, Spain.

Background: Vitrification is the safest method to cryopreserve oocytes, however the process alters mitochondrial function resulting from increased reactive oxygen species (ROS) production. Our aim was to alleviate ROS stress in vitrified mice oocytes using N-acetylcysteine (NAC at 1 mM), to improve the oocyte's developmental competence.

Results: Hence, four experimental groups were compared: fresh oocytes (F-C), vitrified oocytes (V-C), NAC addition prior to oocyte vitrification (V-NAC-Pre) and NAC addition after vitrification (V-NAC-Post). Read More

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http://dx.doi.org/10.1186/s12917-018-1743-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337864PMC
January 2019
3 Reads

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.

Redox Biol 2019 Feb 22;21:101050. Epub 2018 Nov 22.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:

Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic acid (NO-OA) is an electrophilic fatty acid formed under digestive and inflammatory conditions that both reacts with GSH and induces its synthesis upon activation of Nrf2 signaling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183064
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http://dx.doi.org/10.1016/j.redox.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348771PMC
February 2019
5 Reads

Antimicrobial Activity and Cytotoxicity to Tumor Cells of Nitric Oxide Donor and Silver Nanoparticles Containing PVA/PEG Films for Topical Applications.

ACS Appl Mater Interfaces 2019 Feb 1;11(6):6589-6604. Epub 2019 Feb 1.

Tropical Disease Laboratory, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology , University of Campinas (UNICAMP) , Campinas , São Paulo 13083-862 , Brazil.

Because of their antibacterial activity, silver nanoparticles (AgNPs) have been explored in biomedical applications. Similarly, nitric oxide (NO) is an important endogenous free radical with an antimicrobial effect and toxicity toward cancer cells that plays pivotal roles in several processes. In this work, biogenic AgNPs were prepared using green tea extract and the principles of green chemistry, and the NO donor S-nitrosoglutathione (GSNO) was prepared by the nitrosation of glutathione. Read More

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http://dx.doi.org/10.1021/acsami.8b19021DOI Listing
February 2019
2 Reads

Hydrogen sulfide (H S): A novel component in Arabidopsis peroxisomes which triggers catalase inhibition.

J Integr Plant Biol 2019 Jan 16. Epub 2019 Jan 16.

Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, C/ Profesor Albareda 1, E-18008 Granada, Spain.

Plant peroxisomes have the capacity to generate different reactive oxygen and nitrogen species (ROS and RNS), such as H O , superoxide radical (O   ), nitric oxide and peroxynitrite (ONOO ). These organelles have an active nitro-oxidative metabolism which can be exacerbated by adverse stress conditions. Hydrogen sulfide (H S) is a new signaling gasotransmitter caused by the posttranslational modification (PTM) persulfidation. Read More

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http://doi.wiley.com/10.1111/jipb.12779
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http://dx.doi.org/10.1111/jipb.12779DOI Listing
January 2019
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Combination of Epigallocatechin Gallate and Sulforaphane Counteracts In Vitro Oxidative Stress and Delays Stemness Loss of Amniotic Fluid Stem Cells.

Oxid Med Cell Longev 2018 17;2018:5263985. Epub 2018 Dec 17.

Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.

Amniotic fluid stem cells (AFSCs) are characterized by a unique niche guarantying their homeostatic role in the body. Maintaining the functionality of stem cells for clinical applications requires a continuous improvement of cell culture conditions. Cellular redox status plays an important role in stem cell biology as long as reactive oxygen species (ROS) concentration is finely regulated and their adverse effects are excluded. Read More

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https://www.hindawi.com/journals/omcl/2018/5263985/
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http://dx.doi.org/10.1155/2018/5263985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311758PMC
February 2019
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Extracts of Peels and Seeds of Five Varieties of Brazilian Jabuticaba Present High Capacity to Deactivate Reactive Species of Oxygen and Nitrogen.

Plant Foods Hum Nutr 2019 Jan 15. Epub 2019 Jan 15.

Department of Food Science, Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato 80, Campinas, SP, 13083-862, Brazil.

Jabuticaba has a high concentration of phenolic compounds, which have a significant antioxidant capacity. Methodologies have been developed to evaluate the ability of plant extracts to fight free radicals such as HO, O-, HOCl, ONOO- and ROO. Thus, the capacity of deactivation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in peel and seed extracts of five varieties of jabuticaba was evaluated. Read More

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http://link.springer.com/10.1007/s11130-019-0712-7
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http://dx.doi.org/10.1007/s11130-019-0712-7DOI Listing
January 2019
6 Reads

Iron as a Central Player and Promising Target in Cancer Progression.

Int J Mol Sci 2019 Jan 11;20(2). Epub 2019 Jan 11.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell proliferation and growth. On the other hand, iron may be detrimental due to its redox abilities, thereby contributing to free radical formation, which in turn may provoke oxidative stress and DNA damage. Read More

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http://dx.doi.org/10.3390/ijms20020273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359419PMC
January 2019
1 Read

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.

Redox Biol 2019 Feb 26;21:101091. Epub 2018 Dec 26.

Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We propose that one consequence of dietary overnutrition is increased abundance of Gram-negative bacteria in the gut that cause increased inflammation, impaired gut function, and endotoxemia that further dysregulate the already compromised antioxidant vitamin status in MetS. This discussion is timely because "healthy" individuals are no longer the societal norm and specialized dietary requirements are needed for the growing prevalence of MetS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183094
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http://dx.doi.org/10.1016/j.redox.2018.101091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327911PMC
February 2019
3 Reads

Ultrathin BiWO nanosheets loaded g-CN quantum dots: A direct Z-scheme photocatalyst with enhanced photocatalytic activity towards degradation of organic pollutants under wide spectrum light irradiation.

J Colloid Interface Sci 2019 Mar 2;539:654-664. Epub 2019 Jan 2.

College of Environmental Science and Engineering, Hunan University, Changsha 410082, China; Key Laboratory of Environmental Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, China.

A novel ultrathin BiWO nanosheets loaded g-CN quantum dots (CNQDs/BWO) photocatalyst was successfully fabricated, and used to catalyze two representative organic pollutants, rhodamine B (RhB) and tetracycline (TC) under wide spectrum light irradiation. The degradation experiments showed that CNQDs/BWO exhibited enhanced photocatalytic activities towards degradation of organic pollutants. Under visible light irradiation, the 5% CNQDs/BWO exhibited the best degradation efficiency with 87% and 92. Read More

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http://dx.doi.org/10.1016/j.jcis.2018.12.112DOI Listing
March 2019
7 Reads
3.368 Impact Factor