261,965 results match your criteria Fracture Tibia and Fibula


Phosphatidyl Inositol 3-Kinase (PI3K)-mTOR Inhibitor PKI-402 Inhibits Breast Cancer Induced Osteolysis.

Cancer Lett 2018 Dec 9. Epub 2018 Dec 9.

Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China, 515041. Electronic address:

Bone metastasis causes bone pain and pathological bone fracture in breast cancer patients with a serious complication. Previous studies have demonstrated that a novel phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 suppressed the growth of breast cancer cells. However, the role of PKI-402 involved in osteolysis induced by breast cancer remains unclear. Read More

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December 2018

Comparison of Wide-Awake Local Anesthesia No Tourniquet With General Anesthesia With Tourniquet for Volar Plating of Distal Radius Fracture.

Orthopedics 2018 Dec 11:1-6. Epub 2018 Dec 11.

Wide-awake local anesthesia no tourniquet (WALANT) is used for various hand surgeries, but there are no reports of its use for distal radius fractures. The authors compared perioperative variables and clinical outcomes for volar plating for distal radius fractures with WALANT vs general anesthesia with tourniquet. This retrospective study included 47 patients who presented with distal radius fractures between January 2015 and February 2017. Read More

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December 2018

Occlusion Outside the Norm: A Unique Case of the Pulseless, Well-Perfused Hand Following Closed Humeral Shaft Fracture.

Orthopedics 2018 Dec 11:1-3. Epub 2018 Dec 11.

Transient arterial injury is a common complication encountered in the management of pediatric supracondylar humerus fractures, often presenting as a pulseless hand that appears well perfused, also known as the "pink, pulseless hand." Arterial injuries in pediatric humeral shaft fractures, on the other hand, are exceedingly rare, especially in closed fractures. The authors report a rare case of a humeral shaft fracture presenting as a pink, pulseless hand. Read More

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December 2018

Novel Treatment Options for the Surgical Management of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S33-S37

Orthopaedic Trauma Service, Hospital for Special Surgery, New York, NY.

In physiologically young patients with displaced femoral neck fractures, surgical treatment is aimed at achieving fracture union while preserving native hip anatomy and biomechanics. The intracapsular environment, tenuous vascular supply, and unfavorable hip biomechanics contribute to the high complication rates seen after osteosynthesis of these fractures. Conventional fixation methods for osteosynthesis of femoral neck fractures include multiple cancellous screws, fixed-angle dynamic implants, and fixed-angle length-stable constructs. Read More

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January 2019

Biomechanics of Femoral Neck Fractures and Implications for Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S27-S32

*Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; and †Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria.

Fractures of the femoral neck can occur in young healthy individuals due to high loads occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts occur sideways onto the greater trochanter as compared with vertical loading of the hip. Bone density, bone geometry, and thickness of cortical bone at the femoral neck contribute to its mechanical strength. Read More

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January 2019

Technologies for Young Femoral Neck Fracture Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S20-S26

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Fixation of young femoral neck fractures represents a challenge in the field of orthopaedic trauma surgery. Conventional methods, including cannulated screw and sliding hip screw constructs, have been studied and found to have similar results with regards to patient outcomes, which has made choosing an optimum fixation strategy difficult. In all of these cases, quality of reduction has been shown to be the most important factor when it comes to creating a favorable environment for fracture healing. Read More

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January 2019

Reduction Techniques for Young Femoral Neck Fractures.

Authors:
Jason Halvorson

J Orthop Trauma 2019 Jan;33 Suppl 1:S12-S19

Department of Orthopedic Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC.

Young femoral neck fractures remain challenging fractures to treat. Reduction has repeatedly been shown to be the single most important determinant of patient outcome, and treating surgeons should do all they can to achieve anatomic reduction because this is an outcome variable within the surgeon's control. Whether an open or closed reduction is performed, we hope to provide the reader with reduction strategies when faced with this difficult fracture pattern. Read More

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January 2019

Treatment of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S1-S6

Department Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Femoral neck fractures in the physiologically young patient are challenging injuries to manage. A tenuous blood supply and the intrasynovial nature of the fracture create a challenging biological environment. To make matters worse, the biomechanics are equally problematic. Read More

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January 2019

A Quartet of Elastic Stable Intramedullary Nails for More Challenging Pediatric Femur Fractures.

J Pediatr Orthop 2019 Jan;39(1):e12-e17

Children's Healthcare of Atlanta.

Introduction: The insertion of 2 elastic stable intramedullary nails (ESINs) is a common treatment for pediatric femur fractures. However, the use of this technique in length-unstable or metadiaphyseal fractures has historically been associated with higher complication rates. To improve stability, the addition of a third ESIN has been assessed biomechanically and clinically, but the addition of a fourth nail has only been evaluated biomechanically. Read More

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January 2019

No difference in outcomes in a matched cohort of operative versus nonoperatively treated displaced medial epicondyle fractures.

J Pediatr Orthop B 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Children's Hospital of Colorado.

The purpose of our study was to compare the treatment outcomes and complications between operatively and nonoperatively treated displaced medial epicondyle fractures. Pediatric patients treated for an acute, displaced medial epicondyle fracture between 2005 and 2015 were retrospectively reviewed. A total of 22 operative participants were matched to 22 nonoperative participants, with an average displacement of 9. Read More

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December 2018

Clavicle Fracture Malunion Treated with an Osteotomy Guided by a Three-Dimensional-Printed Model: A Case Report.

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, University of California, San Francisco Medical Center, San Francisco, California.

Case: This case report describes the management of a chronic and symptomatic clavicle malunion with use of a 3-dimensional (3D)-printed model during the preoperative surgical planning.

Conclusion: The use of 3D printing has many applications in the medical field. Constant improvement in the quality of 3D printing has contributed to its increased use in a variety of surgeries. Read More

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December 2018

Screening, prevention and management of osteoporosis among Canadian adults.

Health Promot Chronic Dis Prev Can 2018 Dec;38(12):445-454

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: This study provides a benchmark for the nationwide use of osteoporosis screening, prevention and management strategies among Canadians aged 40 years and older (40+) using data collected one year prior to the release of Osteoporosis Canada's latest (2010) clinical practice guidelines.

Methods: Data are from the 2009 Canadian Community Health Survey-Osteoporosis Rapid Response Component. The study sample (n = 5704) was divided into four risk subgroups: (1) osteoporosis diagnosis and major fracture; (2) osteoporosis diagnosis only; (3) major fracture only; or (4) neither osteoporosis diagnosis nor major fracture. Read More

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December 2018

Effect of diode laser irradiation on the bond strength of polymerized non-simplified adhesive systems after 12 months of water storage.

J Appl Oral Sci 2018 Dec 10;27:e20180126. Epub 2018 Dec 10.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Dentística, Endodontia e Materiais Odontológicos, Bauru, São Paulo, Brasil.

Objectives: The aim of this in vitro study was to evaluate the bonding strength of non-simplified dentin bonding systems (DBS) to dentin irradiated with a diode laser (970 nm) immediately and after 12 months of water storage following either primer or bond application.

Material And Methods: The experimental design included three different factors: DBS type [AdperTM Scotchbond Multipurpose (MP) and Clearfil™ SE Bond (CSE)], irradiation [without irradiation - control (C), irradiation after primer application (AP), and irradiation after bond application (AB)], and time [initial (I) and after 12 months of water storage (12 m)]. Sixty sound human third molars (n = 10) were obtained, and their flat occlusal dentin areas were prepared and standardized. Read More

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December 2018

Utility of early active motion for flexor tendon repair with concomitant injuries: A multivariate analysis.

Injury 2018 Dec 22;49(12):2248-2251. Epub 2018 Oct 22.

Department of Orthopaedic Surgery, Nagoya Ekisaikai Hospital, 4-66 Shonen-Cho, Nakagawa-Ku, Nagoya, 454-8502, Japan.

Introduction: Flexor tendon injury often occurs with concomitant injuries such as fracture, vascular injury, and extensor tendon injury. These injuries are repaired independently, without a comprehensive strategy. We aimed to identify the effect of concomitant injuries and treatment choice on the outcome of flexor tendon repair. Read More

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December 2018

Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Viale Piazza D'Armi, 1, 28100, Novara, Italy.

Background: Physical exercise and nutrition seem to have a key role in the management of hip fracture patients.

Aim: To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients.

Methods: In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. Read More

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December 2018

Large opening gaps, unstable hinge fractures, and osteotomy line below the safe zone cause delayed bone healing after open-wedge high tibial osteotomy.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Hokuriku Hospital, 2-13-43 Izumigaoka, Kanazawa, 921-8035, Japan.

Purpose: To evaluate bone formation in the osteotomy gap after open-wedge high tibial osteotomy (OWHTO), including after plate removal, and to investigate risk factors for delayed bone healing.

Methods: Ninety-three patients (102 knees) who underwent OWHTO without bone grafting were enrolled. The osteotomy gap was divided into the lateral hinge and the four zones on anteroposterior radiographs, and we defined the zone in which trabecular bone continuity could be observed as gap filling. Read More

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December 2018

Prevention of postoperative bleeding in hip fractures treated with prosthetic replacement: efficacy and safety of fibrin sealant and tranexamic acid. A randomised controlled clinical trial (TRANEXFER study).

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Public Health and Clinical Epidemiology Service-Iberoamerican Cochrane Centre, IIB Sant Pau. CIBERESP, Barcelona, Spain.

Introduction: We assessed the efficacy of fibrin sealant (FS) and tranexamic acid (TXA) administered topically in patients with a hip fracture treated with prosthetic replacement.

Materials And Methods: Parallel, multicentre, open label, randomised, clinical trial. We compared three interventions to reduce blood loss: (1) 10 ml of FS, (2) 1 g of topical TXA, both administered at the end of the surgery, and (3) usual haemostasis (control group). Read More

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December 2018

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

Combination therapy with parathyroid hormone analogs and antiresorptive agents for osteoporosis: a systematic review and meta-analysis of randomized controlled trials.

Osteoporos Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Spine Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Harbin, Heilongjiang, 150001, People's Republic of China.

Combination therapy with parathyroid hormone (PTH) analogs and antiresorptive agents may be more effective than monotherapy for the treatment of osteoporosis. This study aimed to estimate the effectiveness and safety of this combination therapy for osteoporosis. MEDLINE, EMBASE, and Cochrane Library were searched from inception to May 1, 2018, including randomized controlled trials (RCTs) with a duration of at least 6 months on adults with osteoporosis treated with combination therapy versus monotherapy. Read More

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December 2018

A summer wave of vertebral fractures: the "deck-slap" injury.

Acta Neurochir (Wien) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Sainte-Anne Military Hospital, BP 600, 83800, Toulon Cedex 09, France.

Background: Every summer, several patients who suffer from vertebral fractures are hospitalized at the Sainte-Anne Military Hospital after going on a boat trip around the French Riviera. The uniqueness of these fractures lies in their mechanism of injury, called the "deck-slap" injury. The aim of this study is to describe the characteristics of the "deck-slap" injury. Read More

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December 2018

[Diagnostics and treatment of acute scaphoid fractures].

Unfallchirurg 2018 Dec 11. Epub 2018 Dec 11.

Abteilung für Plastische, Hand- und Rekonstruktive Chirurgie, BG Unfallklinik Frankfurt, Friedberger Landstr. 430, 60389, Frankfurt am Main, Deutschland.

Background: Fractures of the scaphoid bone are common but can easily be overlooked in standard X‑rays. Inadequate diagnostics and therefore inappropriate treatment of scaphoid fractures often leads to problems in healing with formation of non-union and painful osteoarthritis of the wrist.

Objective: This review summarizes the current practical recommendations in the diagnostics and treatment of acute scaphoid fractures. Read More

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December 2018

Inversion of the acetabular labrum causes increased localized contact pressure on the femoral head: a biomechanical study.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan.

Purpose: Although studies suggest that subchondral insufficiency fracture of the femoral head may cause rapidly progressive osteoarthritis of the hip, the mechanism of that relationship remains unclear. Our biomechanical study aimed to provide more data in this area by quantifying pressure distribution on the femoral head for normal and inverted hips and by determining the effects of labral inversion on pressure distribution across the joint, focusing on types of fracture under load.

Methods: We tested mid-sized fourth-generation composite femurs at 15° of adduction, and applied 1 mm/min of axial compressive force to the femoral heads until failure. Read More

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December 2018

Occult injuries of the contralateral sacroiliac joint in operatively treated pelvis fractures: incidence, root cause analysis, and proposal of treatment algorithm.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics, Denver Health Medical Center, 777 Bannock Street, Denver, CO, 80204, USA.

Purpose: To determine the most common injury patterns, root cause, and the frequency with which unrecognized contralateral posterior ring injury occurs in patients presenting with surgically treated pelvic fractures.

Methods: The medical records of 73 patients presenting to our level I trauma center (52 male and 21 female patients; mean age 41.8 years; range 18-89 years) with surgically treated pelvic ring fractures between January 1, 2016 and January 1, 2018 were reviewed. Read More

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December 2018

A new classification for proximal femur bone defects in conservative hip arthroplasty revisions.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Orthopaedic and Traumatologic Department, Santo Spirito General Hospital, Rome, Italy.

Introduction: In the last three decades, total hip replacement in young patient became a habitual procedure. Principles of bone preservation are pushing many surgeons to implant conservative femoral components in patient younger than 65 years. Despite an overall good survivorship and clinical outcomes of conservative implants, failed cases are reported and the need to revise a conservative femoral component became an occasional procedure (with high prevalence of failed resurfacing implants). Read More

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December 2018

[Patellar sleeve fractures : Bracing and augmentation technique with suture tape].

Oper Orthop Traumatol 2018 Dec 11. Epub 2018 Dec 11.

Abteilung für Sportorthopädie, Klinikum rechts der Isar, Ismaninger Str. 22, 81675, München, Deutschland.

Objective: Transosseous augmentation of patellar sleeve fractures (PSF) with suture tape in young athletes.

Indications: Acute avulsions of the proximal or distal patellar pol with clinical relevant deficit of knee extension.

Contraindications: Local infections, severe soft tissue damage (relative contraindication), fractures of the patella or tibial tuberosity. Read More

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December 2018

Analyses of clinical outcomes after severe pelvic fractures: an international study.

Trauma Surg Acute Care Open 2018 21;3(1):e000238. Epub 2018 Nov 21.

Riverside University Health System Medical Center and Loma Linda University School of Medicine, Riverside, California, USA.

Background: This study aimed to compare treatment outcomes between patients with severe pelvic fractures treated at a representative trauma center that was established in Korea since 2015 and matched cases treated in the USA.

Methods: Two cohorts were selected from a single institution trauma database in South Korea (Ajou Trauma Data Bank (ATDB)) and the National Trauma Data Bank (NTDB) in the USA. Adult blunt trauma patients with a pelvic Abbreviated Injury Scale >3 were included. Read More

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November 2018

Isolated hip fracture in the elderly and time to surgery: is there an outcome difference?

Trauma Surg Acute Care Open 2018 23;3(1):e000212. Epub 2018 Nov 23.

Department of Surgery, Kendall Regional Medical Center, Miami, Florida, USA.

Background: Early operative intervention for hip fractures in the elderly is advised to reduce mortality and morbidity. Postoperative complications impose a significant burden on patient outcomes and cost of medical care. Our aim was to determine the relationship between time to surgery and postoperative complications/mortality in patients with hip fracture. Read More

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November 2018

The effect of botulinum toxin-A injection into the masseter muscles on prevention of plate fracture and post-operative relapse in patients receiving orthognathic surgery.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):36. Epub 2018 Nov 25.

Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, Gangneung, Gangwondo 25457 Republic of Korea.

Background: Botulinum toxin-A (BTX-A) injection into muscle reduces muscular power and may prevent post-operative complication after orthognathic surgery. The purpose of this study was (1) to evaluate BTX-A injection into the masseter muscle on the prevention of plate fracture and (2) to compare post-operative relapse between the BTX-A injection group and the no injection group.

Methods: Sixteen patients were included in this study. Read More

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December 2018

Testicular Rupture or Testicular Fracture? A Case Report and Literature Review.

Case Rep Urol 2018 14;2018:1323780. Epub 2018 Nov 14.

Department of Urology, St George's Hospital, London, UK.

Testicular trauma is relatively uncommon. However, severe injuries can result in many complications and should be carefully diagnosed and managed. We present a case of testicular fracture diagnosis made by ultrasonography. Read More

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November 2018

Local Anesthetic Wound Infiltration after Osteosynthesis of Extracapsular Hip Fracture Does Not Reduce Pain or Opioid Requirements: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial in 49 Patients.

Pain Res Manag 2018 13;2018:6398424. Epub 2018 Nov 13.

Department of Orthopaedics and Traumatology, Odense University Hospital and University of Southern Denmark, Odense, Denmark.

Background And Purpose: Local infiltration analgesia (LIA) supports early mobilization after hip and knee arthroplasty. Inspired by this, we studied the effectiveness of wound infiltration with the long acting local anesthetic ropivacaine in an effort to decrease the need for postoperative opioids after osteosynthesis of extracapsular hip fracture.

Methods: Forty-nine patients undergoing osteosynthesis with a sliding hip screw were randomized into two groups in a double-blind study (ClinicalTrials. Read More

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November 2018

The expressions of NGF and VEGF in the fracture tissues are closely associated with accelerated clavicle fracture healing in patients with traumatic brain injury.

Ther Clin Risk Manag 2018 21;14:2315-2322. Epub 2018 Nov 21.

Department of Orthopedics, Liuzhou General Hospital, Liuzhou 545006, Guangxi, China,

Background: Angiogenesis and bone formation are vital for fracture healing. Nerve growth factor (NGF) not only promotes neuronal survival but also enhances the proliferation and differentiation of osteoblasts. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. Read More

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November 2018

Catheter Fracture of Subclavian Venous Chemoport Device at Costoclavicular Junction: Pinch-off Syndrome.

Indian J Surg Oncol 2018 Dec 30;9(4):595-597. Epub 2018 Jul 30.

1Department of Surgical Oncology, Max Super-specialty Hospital, Saket, New Delhi, India.

Chemoport is most commonly used venous access devices for instillation of chemotherapeutic drugs in cancer care. Mechanical complications like catheter fracture can lead to serious morbidity, albeit occurring rarely. We present a case of a 35-year-old lady, a case of carcinoma breast, who had spontaneous fracture of chemoport access device in subclavian vein at the level of clavicle after four successful cycles of chemotherapy. Read More

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December 2018

Functional performance and safety of bone-anchored prostheses in persons with a transfemoral or transtibial amputation: a prospective one-year follow-up cohort study.

Clin Rehabil 2018 Dec 12:269215518815215. Epub 2018 Dec 12.

4 Department of IQ Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives:: (1) To compare level of function, activity, health-related quality of life (HRQoL) and satisfaction in persons with a lower extremity amputation before surgery and 6- and 12-months after implantation of an osseointegration implant and (2) to report adverse events.

Design:: Prospective cohort study.

Setting:: University medical centre. Read More

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December 2018

Enhanced stent visualization systems during PCI: A case series and review of literature.

J Cardiol Cases 2015 Jul 29;12(1):1-5. Epub 2015 Mar 29.

Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Cona FE, Italy.

Enhanced stent visualization systems increase the amount and quality of information during percutaneous coronary interventions. When compared to imaging techniques such as intravascular ultrasound and optical coherence tomography, enhanced stent visualization systems are easy-to-use, as well as time and cost saving. They are useful during stent implantation, overlap, assessment of integrity, and expansion. Read More

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Very late stent thrombosis after paclitaxel-eluting stent implantation with full neointimal tissue coverage visualized by optical coherence tomography.

J Cardiol Cases 2013 Jun 25;7(6):e168-e170. Epub 2013 Mar 25.

Division of Cardiology, Department of Internal Medicine, and Memorial Heart Center, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.

We present findings of a very late stent thrombosis (VLST) involving paclitaxel-eluting stents (PESs) that were fully covered by thin neointima, visualized by optical coherence tomography (OCT) in a patient receiving dual antiplatelet therapy. A 69-year-old Japanese man had been treated with 2 overlapping PESs for chronic coronary artery disease in the proximal right coronary artery. A follow-up coronary computed tomography angiography showed no restenosis in the stent site, and the result of stress myocardial perfusion imaging showed no ischemic changes. Read More

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A case of fractured guide wire perforating the coronary artery and ascending aorta during percutaneous coronary intervention.

J Cardiol Cases 2013 May 13;7(5):e137-e141. Epub 2013 Feb 13.

Division of Cardiovascular Surgery, Nagoya City East Medical Center, Nagoya, Japan.

We experienced a rare and serious case of fractured hydrophilic guide wire necessitating surgical intervention during percutaneous coronary intervention (PCI) for a tortuous and calcified stenosis in the proximal right coronary artery. An 85-year-old female presented to our hospital and was diagnosed as having unstable angina. A 0. Read More

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Recurrent episode of very late stent thrombosis in a patient who underwent percutaneous coronary intervention with sirolimus-eluting stent: Same or different mechanism?

J Cardiol Cases 2012 Feb 6;5(1):e8-e11. Epub 2011 Dec 6.

Cardiology Division, Department of Internal Medicine, Heart Center, Gil Hospital, Gachon University, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Republic of Korea.

We describe a case of a young patient with a recurrent episode of very late stent thrombosis (VLST) in whom the sirolimus-eluting stent was implanted on the culprit lesion in the left anterior descending artery. The present case showed when the etiology of VLST was not clear or in doubt of stent fracture, vigorous investigation for other causes using high resolution technology such as intravascular ultrasound or computed tomography angiography might be helpful for prevention of catastrophic events such as VLST. Read More

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February 2012

Failure mode in first-principles computational tensile tests of grain boundaries: effects of a bulk-region size, dominant factors, and local-energy and local-stress analysis.

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

Tohoku Daigaku Daigakuin Kogaku Kenkyuka Kogakubu, Sendai, Miyagi, JAPAN.

A first-principles computational tensile test (FPCTT) is a powerful tool to investigate intrinsic strength and failure processes of grain boundaries (GBs), according to atomic and electronic behaviors based on density-functional theory, while careful interpretation is required in comparison with experiments, because of ideal conditions used in FPCTTs. We observed serious effects of a bulk-region size in FPCTTs of the {001} Σ5 GB in Al. For a GB supercell with enough thick bulk regions, the energy-strain curve shows spontaneous failure with catastrophic energy release just after the maximum stress point, which we name Type-A failure. Read More

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December 2018

Sclerosing bone dysplasias with hallmarks of dysosteosclerosis in four patients carrying mutations in SLC29A3 and TCIRG1.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Institut für Medizinische Genetik und Humangenetik, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

The osteopetroses and related sclerosing bone dysplasias can have a broad range of manifestations. Especially in the milder forms, sandwich vertebrae are an easily recognizable and reliable radiological hallmark. We report on four patients from three families presenting with sandwich vertebrae and platyspondyly. Read More

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December 2018
1 Read

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative.

Bone 2018 Dec 8. Epub 2018 Dec 8.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Background: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.

Methods: 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Read More

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December 2018
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Original vs. non-original abutments for screw-retained single implant crowns: An in vitro evaluation of internal fit, mechanical behaviour and screw loosening.

Clin Oral Implants Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Buccofacial Prosthesis, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.

Objectives: To assess the internal accuracy, mechanical behaviour under static load and screw loosening before and after cyclic loading of implant-supported crowns restored with original components or with two compatible non-original brands.

Materials And Methods: Sixty-three dental implants were divided into three groups (n = 21 each): Group 1 used original components, and groups 2 and 3 used non-original components. Internal accuracy was measured throughout a cross section of the sample groups (n = 8) using scanning electron microscopy (SEM) to evaluate the fit for implant-abutments, implant-crowns and crown-abutments. Read More

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November 2018
1 Read

Recommendations for Iliosacral Screw Placement in Dysmorphic Sacrum based on Modified In-Out-In Corridors.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Clinic of Orthopaedics and Sportsorthopaedics, Klinikum rd. Isar, Technische Universität München, Munich, Germany.

(1) Can iliosacral osseous corridor diameters in sacral dysmorphism be enlarged by in-out-in screw placement at the posterior iliosacral recessus? (2) Are lumbosacral transitional vertebra (LSTV) the anatomical cause for sacral dysmorphism? (3) Are there sex-specific differences in sacral dysmorphism? 594 multislice CT scans were screened for sacral dysmorphism and 55 data-sets selected. Each pelvis was segmented manually and cylindrical iliosacral corridors (S1 and S2 vertebra) were semi-automatically determined. Corridor trajectories, -diameters and -lengths were measured. Read More

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December 2018

Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON-PFT Extension I Trials.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

An ASBMR task force recommends a drug holiday for certain women treated for ≥5 years with oral alendronate or ≥3 years with intravenous zoledronic acid, with reassessment 2-3 years later. It is not known whether changes in BMD or bone turnover markers differ after oral or intravenous therapy. Our goal was to compare changes in BMD and procollagen type I N propeptide, PINP, after oral or intravenous bisphosphonate use. Read More

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December 2018

A Comparison of U.S. and Canadian Osteoporosis Screening and Treatment Strategies in Postmenopausal Women.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset). Read More

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December 2018

Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Department of orthopedic oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Osteoporosis is a global bone disease characterized by reduced bone mineral density (BMD) and increased risk of fractures. The risk of developing osteoporosis increases with aging, especially after menopause in women. Discovering the signaling pathways which play a significant role in aging- and menopause-induced osteoporosis should accelerate osteoporosis drug discovery. Read More

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December 2018

Antiresorptive Agents' Bone-protective and Adjuvant Effects in Postmenopausal Women with Early Breast Cancer.

Br J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Endocrinology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Potent antiresorptive drugs (bisphosphonate and denosumab) are often used to protect bone health in postmenopausal breast cancer patients. In addition, clinical trials have shown that these drugs increase disease-free survival, though the mechanism of adjuvant benefit is largely unknown. Here we review the bone health and adjuvant data for both classes of antiresorptive drugs and highlight differences in their pharmacology. Read More

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December 2018

Loss of Lgr4 inhibits differentiation, migration and apoptosis, and promotes proliferation in bone mesenchymal stem cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Shanghai Fengxian District Central Hospital and East China Normal University Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

The key signaling networks regulating bone marrow mesenchymal stem cells (BMSCs) are poorly defined. Lgr4, which belongs to the leucine-rich repeat-containing G protein-coupled receptor (LGR) family, is widely expressed in multiple tissues from early embryogenesis to adulthood. We investigated whether Lgr4 functions in BMSCs and in osteogenesis, adipogenesis, and skeletal myoblasts, using mice with a β-geo gene trap inserted into the Lgr4 gene. Read More

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December 2018

Inflammasomes in Bone Diseases.

Exp Suppl 2018 ;108:269-279

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Unresolved inflammation is harmful to any tissues in the organism. Bone in particular is vulnerable to inflammatory assaults because its integrity depends on the activity of osteoclasts, which arise from myeloid precursors. Osteoclasts are responsible for bone resorption in normal and disease conditions. Read More

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January 2018

Application of the Guiding Template Designed by Three-dimensional Printing Data for the Insertion of Sacroiliac Screws: a New Clinical Technique.

Curr Med Sci 2018 Dec 7;38(6):1090-1095. Epub 2018 Dec 7.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

This study is aimed to explore the clinical application of the guiding template designed by three-dimensional printing data for the insertion of sacroiliac screws. A retrospective study of 7 cases (from July 2016 to December 2016), in which the guiding template printed by the threedimensional printing technique was used for the insertion of sacroiliac screws of patients with posterior ring injuries of pelvis, was performed. Totally, 4 males and 3 females were included in template group, aged from 38 to 65 years old (mean 50. Read More

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December 2018

Computer-assisted Surgery for Scaphoid Fracture.

Curr Med Sci 2018 Dec 7;38(6):941-948. Epub 2018 Dec 7.

Department of Hand Surgery, Beijing Jishuitan Hospital, Beijing, 100035, China.

The computer-assisted surgery (CAS) has significantly improved the accuracy, reliability and outcomes of traumatic, spinal, nerve surgery and many other operations with a less invasive way. The application of CAS for scaphoid fractures remains experimental. The related studies are scanty and most of them are cadaver researches. Read More

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December 2018