J Am Acad Orthop Surg Glob Res Rev 2022 01 11;6(1). Epub 2022 Jan 11.
From the Stony Brook University Hospital, Department of Orthopaedics, Stony Brook, NY (Dr. Shah, Riordan and Dr. Khan); and the Stony Brook University Renaissance School of Medicine, Stony Brook, NY (Bhan and Pey).
Systemic mastocytosis (SM) is pathologically characterized by the proliferation of mast cells with infiltrates in various organs, almost always including bone marrow, leading to defects in bone remodeling. Osteoporosis and subsequent fragility fractures are the most common and clinically relevant presentation, although pathologic fracture through the focal lytic lesions can also be observed. Here, we report the case of a 54-year-old woman, with a recent history of unexplained severe allergic reactions, presenting with intertrochanteric fracture of the left femur which on careful history, physical and radiological evaluation was determined to be pathological. Read More