Dig Dis Sci 2022 Jun 7. Epub 2022 Jun 7.
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Background: Lower whole body bone mineral density (BMD) has been reported in children with nonalcoholic fatty liver disease (NAFLD), but potential mediators remain uncertain.
Aims: To assess BMD at multiple skeletal sites in children with confirmed NAFLD and controls with obesity, adjusting for known determinants of BMD, and examine potential mediators.
Methods: We assessed age-, sex-, and race-specific, and height-adjusted BMD z-scores of whole body, lumbar spine, hip, femoral neck and forearm by dual-energy-x-ray absorptiometry in 79 children, 8-19 years old: 46 with biopsy-confirmed NAFLD [29 steatohepatitis (NASH)/17 fatty liver (NAFL)] and 33 controls without liver disease. Read More