261,725 results match your criteria Fracture Clavicle


Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.

Dement Geriatr Cogn Disord 2018 Dec 6;46(5-6):346-357. Epub 2018 Dec 6.

Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.

Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More

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December 2018
2 Reads

[Interlocking femoral nail and total knee Arthroplasty in one stage for a patient with a femoral diaphyseal stress fracture].

Acta Ortop Mex 2018 May-Jun;32(3):163-166

Servicio de Cirugía Ortopédica y Traumatología, Hospital de Sabadell. Institut Universitari Parc Taulí Universitat Autònoma de Barcelona, España.

We present the case of an 81-year-old woman who was followed up by the Rheumatology Service for osteoporosis and treated with bisphosphonates for more than five years. She reported a fracture of the distal third of the contralateral femur by a low energy mechanism, treated with retrograde intramedullary nailing the previous year. She presented a clinic of cruralgia and left gonalgia, without previous trauma. Read More

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December 2018

[Complex fractures of the clavicles lateral third].

Acta Ortop Mex 2018 May-Jun;32(3):140-144

Módulo de Cirugía de Hombro y Codo, Hospital General Xoco. Av. México Coyoacán S/N, Col. General Anaya, Deleg. Benito Juárez, CP 03340, Ciudad de México, México.

Background: Fractures of the lateral third of the clavicle represent 18% of all clavicle fractures. Even though non-displaced fractures can be managed conservatively, displaced fractures have a non-union percentage of 30%. Multiple approaches have been proposed to manage the displaced fractures. Read More

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December 2018
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[Functional results and complications of the use of the proximal femoral nail in the treatment of intertrochanteric hip fractures].

Acta Ortop Mex 2018 May-Jun;32(3):126-130

Centro de Evaluación de Tecnologías, Universidad CES, Medellín, Colombia.

Introduction: Cephalomedullary nails are used for the treatment of hip fractures; however, there are few studies that allow identifying data on the complications of the use of these devices and the results in terms of restoration of the functionality of the patient.

Methods: A cross-sectional study of patients with femur fracture was conducted during the period from January 2008 to December 2012. Data on demographic and clinical variables were collected. Read More

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December 2018

[Infrapectineal plate for repair with minimal invasion of quadrilateral blade acetabular fractures: description new implant and paramedial access].

Acta Ortop Mex 2018 May-Jun;32(3):118-125

Instituto de Astronomía de la Universidad Nacional Autónoma de México.

Introduction: Quadrilateral plate fractures are the most difficult to reduce and fix. Different techniques have been developed for quadrilateral plate osteosynthesis. The objective of this work was to create an implant and a novel approach to simplify and improve acetabular fracture osteosynthesis. Read More

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December 2018

Comparative study of immediate loading on short dental implants and conventional dental implants in the posterior mandible: A randomized clinical trial.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Immediate dental implant loading has been investigated with favorable results. However, short implants have not been investigated in this treatment option. This study compared the clinical outcomes and survival rates of immediately loaded short and conventional length dental implants in replacing mandibular molar teeth. Read More

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December 2018

The orthogeriatric units in Mexico are a priority

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):332-333. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital General Regional No. 2 Villa Coapa, Servicio de Ortogeriatría. Ciudad de México, México

Hip fracture is a public health problem, 85% of cases occur in people older than 65 years of age. The Orthogeriatric Unit is a multidisciplinary model that helps to reduce the average hospital stay, mortality and postoperative complications; it allows the recovery of previous functionality, decreases the dependence degree and associated costs. Read More

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November 2018

Full-arch implant supported rehabilitations: A prospective study comparing porcelain-veneered zirconia frameworks to monolithic zirconia.

Clin Oral Implants Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Oral Surgery and Implant Dentistry, Faculdade de Medicina Dentária da Universidade de Lisboa, Portugal.

Objectives: To evaluate the performance of two types of zirconia frameworks.

Material And Methods: From 2014 to 2016, in a prospective clinical trial 150 patients were rehabilitated with 83 and 110 implant-supported, screw-retained, full-arch ceramic-veneered zirconia (PVZ) rehabilitations and monolithic zirconia with porcelain veneering limited to buccal (MZ) rehabilitations, respectively. Patients were consecutively enlisted according to pre-defined inclusion criteria and evaluated on 4 months intervals. Read More

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December 2018

Computerized anatomy of the distal radius and its relevance to volar plating, research, and teaching.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

AO Research Institute Davos, Davos, Switzerland.

Distal radius fractures are common and fracture patterns and fixation can be complex. Computerized anatomy evaluation (CAE) might offer non-invasive and enhanced anatomy assessment that might help with implant selection and placement and screw length determination. Our goal was to test the accuracy of two CAE methods for anatomical volar plate positioning and screw lengths measurement of the distal radius. Read More

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December 2018

Mechanical Behavior of Posterior All-Ceramic Hybrid-Abutment-Crowns Versus Hybrid-Abutments with Separate Crowns - A Laboratory Study.

Clin Oral Implants Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Prosthodontics, Propaedeutic and Dental Materials, School of Dentistry, Christian-Albrechts University, Kiel, Germany.

Objective: The purpose of this laboratory study was to evaluate the fatigue resistance, fracture resistance and mode of failure of posterior hybrid-abutment-crown versus hybrid-abutment with separate crown, both bonded to short titanium bases.

Materials And Methods: Thirty-two titanium implants were embedded perpendicularly in auto-polymerizing resin. Implant-supported restorations simulating a maxillary first premolar were designed and milled using a CAD/CAM system and divided into 2 groups according to material (n=16): zirconia (Z) and lithium disilicate (L). Read More

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December 2018

Assessment of Hedgehog Signaling Pathway Activation for Craniofacial Bone Regeneration in a Critical-Sized Rat Mandibular Defect.

JAMA Facial Plast Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville.

Importance: Osseous craniofacial defects are currently reconstructed with bone grafting, rigid fixation, free tissue transfer, and/or recombinant human bone morphogenetic protein 2. Although these treatment options often have good outcomes, they are associated with substantial morbidity, and many patients are not candidates for free tissue transfer.

Objective: To assess whether polysaccharide-based scaffold (PS) constructs that are cross-linked with smoothened agonist (SAG), vascular endothelial growth factor (VEGF), and bone morphogenetic protein 6 (BMP-6) would substantially increase bone regeneration. Read More

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December 2018

S1 Pedicle Subtraction Osteotomy for Fixed Sagittal Imbalance and Lumbosacral Kyphosis.

Clin Spine Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, NY.

S1 pedicle subtraction osteotomies (PSOs) are indicated in patients with fixed, high-grade L5-S1 spondylolisthesis or kyphosis secondary to a sacral fracture, who present with severe sagittal imbalance. Unlike lumbar PSOs, sacral osteotomies are rare, and there is a paucity of literature outlining techniques. Here, we present the indications, planning, technique, and outcomes for S1 PSOs. Read More

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December 2018
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Toughening Nanoparticle Films via Polymer Infiltration and Confinement.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Disordered nanoparticle films have significant technological applications as coatings and membranes. Unfortunately, their use to date has been limited by poor mechanical properties, notably low fracture toughness, which often results in brittle failure and cracking. We demonstrate that the fracture toughness of TiO nanoparticle films can be increased by nearly an order of magnitude through infiltration of polystyrene into the film. Read More

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December 2018

Management of Paediatric Buckle (Torus) Wrist Fractures in Irish Emergency Departments: A National Survey

Ir Med J 2018 08 13;111(7):793. Epub 2018 Aug 13.

Department of Emergency Medicine, University Hospital Galway, Galway

Buckle fractures are the most common wrist fractures reported in the paediatric age group. National Institute for Clinical Excellence (NICE) recommends using a non-rigid immobilisation with no follow up for these patients and appropriate discharge advice. A telephone survey was conducted to assess the variation in practice in Irish hospitals regarding the mpediatrianagement of buckle fractures. Read More

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Preoperative Myocardial Troponin T Elevation is Associated with the Fracture Type in Patients with Proximal Femoral Fracture.

Scand J Surg 2018 Dec 6:1457496918816928. Epub 2018 Dec 6.

1 Heart Center, Turku University Hospital, Turku, Finland.

Background And Aims:: Cardiovascular complications are common in hip fracture patients but the role of fracture type and operative method in these is unclear. This prospective cohort study aimed to evaluate the impact of fracture- and operative characteristics on perioperative cardiovascular complications and prognosis in unselected hip fracture patients.

Material And Methods:: During a 7-month trial registration period, a population of 197 consecutive hip fracture patients (median age 84 years) diagnosed with femoral neck or pertrochanteric fracture was formed. Read More

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December 2018

Perceptions and experiences of patients following treatment with single-implant mandibular overdentures: a qualitative study.

Clin Oral Implants Res 2018 Dec 5. Epub 2018 Dec 5.

School of Dentistry, Federal University of Goias, Goiania, Goias, Brazil.

Objective: This study aimed to explore the perceptions and long-term experiences of edentulous patients rehabilitated with single-implant mandibular overdentures (SIMO).

Methods: Thirteen participants, mean age 65.7 years, 69. Read More

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December 2018

Minimally invasive plate osteosynthesis (MIPO) in AO/OTA type B displaced clavicle fractures.

Musculoskelet Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Introduction: Open reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique may reduce these complications. Read More

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December 2018

Bone turnover markers, BMD and TBS after short-term, high-dose glucocorticoid therapy in patients with Graves' orbitopathy: a small prospective pilot study.

J Endocrinol Invest 2018 Dec 5. Epub 2018 Dec 5.

Endocrinology Unit, Department of Medicine (DIMED), Università di Padova, Via Ospedale n. 105, 35128, Padua, Italy.

Purpose: Chronic GC administration has numerous side effects, but little is known about the side effects of their short-term use (< 3 months)-particularly, when high doses are involved, as in the treatment of Graves' orbitopathy (GO). We investigated the effects of short-term, high-dose GC on bone turnover markers, bone mineral density (BMD), and trabecular bone scores (TBS).

Methods: Eleven patients (10 females and 1 male; median age 56 years) with active GO who were candidates for treatment with intravenous (iv) methylprednisone were consecutively enrolled. Read More

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December 2018
2 Reads

Vertebral body insufficiency fractures: detection of vertebrae at risk on standard CT images using texture analysis and machine learning.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.

Purpose: To evaluate the diagnostic performance of bone texture analysis (TA) combined with machine learning (ML) algorithms in standard CT scans to identify patients with vertebrae at risk for insufficiency fractures.

Materials And Methods: Standard CT scans of 58 patients with insufficiency fractures of the spine, performed between 2006 and 2013, were analyzed retrospectively. Every included patient had at least two CT scans. Read More

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December 2018

Fabrication of Poly(acrylic acid)/Boron Nitride Composite Hydrogels with Excellent Mechanical Properties and Rapid Self-Healing Through Hierarchically Physical Interactions.

Nanoscale Res Lett 2018 Dec 5;13(1):393. Epub 2018 Dec 5.

Institute for Frontier Materials, Deakin University, Locked Bag 20000, Geelong, Victoria, 3220, Australia.

Many living tissues possess excellent mechanical properties and self-healing ability. To mimic these living tissues, a series of novel composite hydrogels, poly(acrylic acid)/surface-modified boron nitride nanosheets (PAA/BNNS-NH) were fabricated simply through hierarchically physical interactions: molecular-scale metal coordination interaction between -COOH of PAA and Fe and nanoscale H-bond between -COOH of PAA and -NH of BNNS-NH. The composite hydrogels exhibit both excellent mechanical properties (including enhanced fracture stress, elongation, toughness, Young's modulus, and dissipated energy) and rapid healing ability without any external stimulus. Read More

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December 2018

The fate of root canals obturated with Thermafil: 10-year data for patients treated in a master's program.

Clin Oral Investig 2018 Dec 5. Epub 2018 Dec 5.

Endodontic Clinical Section, School of Dentistry, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Via San Vitale 59, 40125, Bologna, Italy.

Objectives: Retrospective description of the 10-year success rate of endodontic treatments with Thermafil (TF).

Materials And Methods: Patients treated by postgraduate students in an Endodontics Master's Program (2006-2008) were enrolled. All treated root canals were filled with TF and AH Plus. Read More

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December 2018

Vertebral fractures cascade: potential causes and risk factors.

Osteoporos Int 2018 Dec 5. Epub 2018 Dec 5.

Rheumatology Department, INSERM 1153, CHU Paris Cochin, Paris Descartes University, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France.

We performed a study to identify potential causes and risk factors of vertebral fracture cascade. Vertebral fracture cascade is a severe clinical event in patients with bone fragility. Only half of patients have an identified cause of secondary osteoporosis. Read More

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December 2018

Continuous improvement process: ortho-geriatric co-management of proximal femoral fractures.

Arch Orthop Trauma Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic and Trauma Surgery, Robert-Bosch-Krankenhaus Stuttgart, Auerbachstrasse 110, 70376, Stuttgart, Germany.

Objective: The objective of the current study was to evaluate the effect of a quality management system on treatment and care delivery of proximal femoral fractures. Specifically, our hypothesis was that the "plan-do-check-act (PDCA)" philosophy of the ISO 9001 quality management system results in a continuous improvement process.

Methods: 1015 proximal femoral fractures were prospectively included into a hip fracture database over a 5-year period, after a restructuring process with implementation of clinical pathways and standard operation procedures. Read More

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December 2018

Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.

Eur J Orthop Surg Traumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, via Pupilli n1, 40136, Bologna, Italy.

Introduction: Combining massive bone allograft and vascularized fibula in intercalary reconstruction following resection of bone tumors represents a complex reconstructive procedure that requires specialists in microvascular surgery as well as orthopedic surgery. The purpose of our study was to examine the outcomes using this surgical technique in patients with bone tumors in terms of oncologic results, complications related to surgery, Musculoskeletal Tumor Society (MSTS) scores and duration of surgery.

Materials And Methods: We analyzed 81 patients with femoral or tibial sarcomas who underwent intercalary resection and microsurgical reconstruction with massive bone allograft and vascularized fibula. Read More

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December 2018

Pain Management during Rehabilitation after Distal Radius Fracture Stabilized with Volar Locking Plate: A Prospective Cohort Study.

Biomed Res Int 2018 5;2018:5786089. Epub 2018 Nov 5.

Department of Orthopedics, First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai, Wenzhou, Zhejiang 325000, China.

Introduction: Internal fixation with volar locking plate (VLP) was widely adopted as a first-line choice in treatment of distal radius fracture (DRF).

Methods: Total 315 patients with distal radius fracture receiving VLP fixation were included for analysis in this study. The rehabilitation protocol was started immediately after surgery for all patients. Read More

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November 2018

Large variations in the practice patterns of surgical antiseptic preparation solutions in patients with open and closed extremity fractures: a cross-sectional survey.

Antimicrob Resist Infect Control 2018 29;7:148. Epub 2018 Nov 29.

3Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON Canada.

Background: Surgically-managed fractures, particularly open fractures, are associated with high rates of surgical site infections (SSIs). To reduce the risk of an SSI, orthopaedic surgeons routinely clean open fracture wounds in the emergency department (ED) and then apply a bandage to the open wound. Prior to the surgical incision, it is standard practice to prepare the fracture region with an antiseptic skin solution as an additional SSI prevention strategy. Read More

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November 2018
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An Optimized Approach to Perform Bone Histomorphometry.

Front Endocrinol (Lausanne) 2018 21;9:666. Epub 2018 Nov 21.

Experimental Trauma Surgery, Faculty of Medicine, Justus-Liebig University of Giessen, Giessen, Germany.

Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone properties because of systemic skeletal diseases like osteoporosis and osteomalacia. Besides, quantitative evaluation plays an important role in fracture healing studies to explore the effect of biomaterial or drug treatment. Read More

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November 2018

Effects of fascia iliaca compartment block combined with general laryngeal mask airway anesthesia in children undergoing femoral fracture surgery: a randomized trial.

J Pain Res 2018 8;11:2821-2826. Epub 2018 Nov 8.

School of Medicine, Jiaxing University, Jiaxing 314000, Zhejiang, China,

Background: Postoperative agitation after general anesthesia is a common complication in children; however, pain or uncomfortable feeling is the main reason of emergence agitation. Here, we have investigated the effects of fascia iliaca compartment block (FICB) combined with general laryngeal mask airway (LMA) anesthesia in children undergoing femoral surgery.

Methods: Eighty children undergoing femoral surgery were randomly divided into two groups: FICB + LMA group and control group (n=40). Read More

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November 2018

Reinforcement of calcium phosphate cement using alkaline-treated silk fibroin.

Int J Nanomedicine 2018 9;13:7183-7193. Epub 2018 Nov 9.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China,

Background: Bone cement plays an important role in the treatment of osteoporotic vertebral compression fractures. Calcium phosphate cement (CPC) is a potential alternative to poly(methyl methacrylate), currently the gold standard of bone cements. However, the poor mechanical properties of CPCs limit their clinical applications. Read More

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November 2018
1 Read

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.

Nat Commun 2018 Dec 5;9(1):5191. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, Duke University, Durham, 27710, USA.

The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are unknown. Here we report that young macrophage cells produce factors that promote osteoblast differentiation of old bone marrow stromal cells. Heterochronic parabiosis exploiting young mice in which macrophages can be depleted and fractionated bone marrow transplantation experiments show that young macrophages rejuvenate fracture repair, and old macrophage cells slow healing in young mice. Read More

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December 2018
10.742 Impact Factor

Early Out-of-Bed Functional Exercise Benefits Elderly Patients Following Hip Fracture: A Retrospective Cohort Study.

Tohoku J Exp Med 2018 ;246(4):205-212

Department of Orthopedic, Traditional Chinese Medicine Hospital of Puning City, Orthopaedic Hospital of Puning City.

Hip fracture is a worldwide medical problem with devastating consequences. Older adults are at higher risk for complications and have more mobility limitation. The aim of this study was to assess the impact of delay in out-of-bed functional exercise on one-year mortality and functional outcomes for elderly patients with hip fracture in China. Read More

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January 2018

Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review.

BMJ Open 2018 Dec 4;8(12):e020757. Epub 2018 Dec 4.

Warwick Medical School, University of Warwick, Coventry, UK.

Objective: Older patients with hip fractures who are undergoing surgery are at high risk of significant mortality and morbidity including postoperative delirium. It is unclear whether different types of anaesthesia may reduce the incidence of postoperative delirium. This systematic review will investigate the impact of anaesthetic technique on postoperative delirium. Read More

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December 2018

Debridement, internal fixation and staged autogenous bone graft for the management of infected femoral non-union.

Injury 2018 Nov 22. Epub 2018 Nov 22.

Hip Department - Orthopedic and Trauma v, I.R.C.C.S. Policlinico San Donato, 20097, San Donato Mil.se, Milan, Italy; Division of Orthopaedic Surgery, McMaster University, Canada.

An infected non-union is a major and potentially devastating complication following bone fractures. It is often debilitating for the patients, physically and psychologically, because of its long healing period and emotional toll on patient and caregivers. Different surgical procedures (in one or two stages) are described in literature for its treatment. Read More

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November 2018

Intercalary allograft reconstruction in a patient with large tibial defect: Case report.

Injury 2018 Oct 16. Epub 2018 Oct 16.

Orthopaedic and Traumatology Division, Department of Medicine and Science of Aging, University of Study "G. d'Annunzio" Chieti-Pescara, Italy.

A fit 26 year-old-man presented to our Department with an open fracture of the left tibial shaft (AO 42-C3). The fracture was initially treated with an External Fixator, which was replaced by an intramedullary Grosse Kempf nail after 4 months. In the following year he developed an atrophic non-union and we witnessed the increasing bone resorption at the fracture site which led to the nail breakage. Read More

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October 2018
1 Read

Treatment of distal clavicle nonunion with and without bone grafting.

Injury 2018 Nov 28. Epub 2018 Nov 28.

Orthopedics and Trauma Unit, Emergency Department, Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genoa, Italy.

The management of distal clavicle nonunion represents a challenging task for orthopaedic trauma surgeon. Both the choice of the implant and whether a bone graft is needed are controversial points which must be addressed. Particularly, in the case of a hypertrophic nonunion, grafting may not necessarily be needed, but given a poor underlying biological environment, a bone graft becomes necessary in order to enhance fracture healing. Read More

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November 2018
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Masquelet technique to treat a septic nonunion after nailing of a femoral open fracture.

Injury 2018 Nov 22. Epub 2018 Nov 22.

Orthopaedics and Trauma Unit, Emergency Department, Ospedale Policlinico San Martino, Largo R. Benzi 10-16132, Genoa, Italy.

Septic nonunion is one of the most serious complications after an open fracture because both the infection and the bone defect need to be dealt with. Treatment is always protracted and expensive, and the result is uncertain. In the 1980s, Masquelet first described the technique of the induced membrane and autologous bone grafting to manage critical bone defects. Read More

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November 2018
2 Reads

Modified Masquelet's technique with nail and allograft: A case report.

Injury 2018 Nov 28. Epub 2018 Nov 28.

Department of Traumatology, IRCCS Humanitas Research Hospital, Milano, Italy.

The large bone defect treatment is a challenge issue in modern orthopaedic trauma surgery. One of the most used technique is the Masquelet's technique. In this case report we used a modified Masquelet technique to fill a six centimeters bone gap in the proximal femur. Read More

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November 2018
3 Reads

Overuse injuries in sport: a comprehensive overview.

J Orthop Surg Res 2018 Dec 5;13(1):309. Epub 2018 Dec 5.

Department of Musculoskeletal Disorders, School of Medicine and Dentistry, University of Salerno, Salerno, Italy.

Background: The absence of a single, identifiable traumatic cause has been traditionally used as a definition for a causative factor of overuse injury. Excessive loading, insufficient recovery, and underpreparedness can increase injury risk by exposing athletes to relatively large changes in load. The musculoskeletal system, if subjected to excessive stress, can suffer from various types of overuse injuries which may affect the bone, muscles, tendons, and ligaments. Read More

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December 2018
2 Reads

Retrospective evaluation of perioperative and short term clinical outcomes in appendicular long bone skeleton fractures repaired via the string of pearls (SOP) locking plate system.

BMC Vet Res 2018 Dec 5;14(1):386. Epub 2018 Dec 5.

Memphis Veterinary Specialists, 555 Trinity Creek Cove, Cordova, TN, 38018, USA.

Background: Internal plate fixation and, more recently, locking plate fixation are commonly used in the repair of fractures in small animal surgery. This retrospective study reviewed the use of the String of Pearls locking plate system in the fixation/repair of appendicular long bone skeleton fractures in 31 small animal veterinary patients (33 fractures).

Results: Major complications necessitating revision surgery occurred in 7/33 (21%), with implant failure as the inciting cause in all cases. Read More

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December 2018
2 Reads

Preparation of low shrinkage stress Bis-GMA free dental resin composites with a synthesized urethane dimethacrylate monomer.

J Biomater Sci Polym Ed 2018 Dec 5:1-26. Epub 2018 Dec 5.

a College of Materials Science and Engineering, South China University of Technology , Guangzhou , 510641 , China.

A new urethane dimethacrylate TMA was synthesized through a typical urethane reaction. TMA was used to replace 1,6-bis(methacryloxy-2-ethoxycarbonyl- amino)-2,4,4- trimethylhexane (UDMA) in UDMA based composite partially or totally to prepare TMA containing composites. Critical properties of TMA containing composites were investigated. Read More

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December 2018
1.648 Impact Factor

Treatment of Osteoporosis, with a Focus on 2 Monoclonal Antibodies.

Med Sci Monit 2018 Dec 3;24:8758-8766. Epub 2018 Dec 3.

Department of Laser Medicine, Chinese People's Liberation Army General Hospital, Beijing, China (mainland).

Osteoporosis is a common skeletal disease characterized by bone loss and subsequent increased risk of fragility fractures. Recent advances in our mechanistic understanding of molecular communications among osteoblasts, osteoclasts, and osteocytes give insight into the important roles of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the process of bone remodeling. Due to the translation of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the regulation of osteoblasts and osteoclasts, new targets have been studied in recent years, such as sclerostin and receptor activator of NF-κB ligand (RANKL). Read More

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December 2018
2 Reads

Anti-nociceptive and anti-inflammatory potentials of Akebia saponin D.

Eur J Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University, Beijing, China. Electronic address:

Akebia saponin D, which is originates from Dipsacus asper Wall, has been used as a tonic, an analgesic and anti-inflammatory agent for the therapy of low back pain, rheumatic arthritis, traumatic hematoma, habitual abortion and bone fractures in traditional Chinese medicine. However, the anti-nociceptive and anti-inflammatory activity and mechanism of Akebia saponin D has been rarely reported. The aim of this study was to investigate the anti-nociceptive and anti-inflammatory activity of Akebia saponin D and to assess its possible mechanism. Read More

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November 2018
3 Reads

One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Amgen Inc., Thousand Oaks, CA, USA.

Romosozumab, a humanized monoclonal antibody that binds and inhibits sclerostin, has the dual effect of increasing bone formation and decreasing bone resorption. As previously reported in the pivotal FRActure study in postmenopausal woMen with ostEoporosis (FRAME), women with a T-score of ≤ -2.5 at the total hip or femoral neck received subcutaneous placebo or romosozumab once monthly for 12 months, followed by open-label subcutaneous denosumab every 6 months for an additional 12 months. Read More

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December 2018
1 Read

Utility of Cement Augmentation via Percutaneous Fenestrated Pedicle Screws for Stabilization of Cancer Related Spinal Instability.

Oper Neurosurg (Hagerstown) 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Cancer patients experience pathological fractures and the typical poor bone quality frequently complicates stabilization. Methods for overcoming screw failure include utilization of fenestrated screws that permit the injection of bone cement into the vertebral body to augment fixation.

Objective: To evaluate the safety and efficacy of cement augmentation via fenestrated screws. Read More

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December 2018

2018 Update on Medical Overuse.

JAMA Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine and Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Overuse of medical care is a well-recognized problem in health care, associated with patient harm and costs. We sought to identify and highlight original research articles published in 2017 that are most relevant to understanding medical overuse.

Observations: A structured review of English-language articles published in 2017 was performed, coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adult care. Read More

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December 2018
4 Reads

Biological Compatibility Profile on Biomaterials for Bone Regeneration.

J Vis Exp 2018 Nov 16(141). Epub 2018 Nov 16.

Department of Pharmacology and Toxicology, University of Vienna;

Large non-union bone fractures are a significant challenge in orthopedic surgery. Although auto- and allogeneic bone grafts are excellent for healing such lesions, there are potential complications with their use. Thus, material scientists are developing synthetic, biocompatible biomaterials to overcome these problems. Read More

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November 2018

Augmented External Fixation of Ulnar Carpometacarpal Joint Fracture Dislocations.

Tech Hand Up Extrem Surg 2018 Nov 30. Epub 2018 Nov 30.

Cleveland Clinic.

Ulnar-sided carpometacarpal (CMC) joint fracture dislocations are relatively uncommon, frequently associated with fractures of the metacarpal base and/or hamate, and often sustained by young male individuals secondary to striking a hard object. The complexity of ulnar-sided CMC fracture dislocations necessitates careful restitution of anatomic alignment and joint congruency for mobility and stability. Miniaturization of the external fixation device has allowed application to the hand. Read More

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November 2018
1 Read