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    164 results match your criteria Fox-Fordyce Disease

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    Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder.
    J Invest Dermatol 2017 Jan 1;137(1):38-45. Epub 2016 Sep 1.
    Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
    Sweat glands are critical for thermoregulation. The single tubular structure of sweat glands has a lower secretory portion and an upper reabsorptive duct leading to the secretory pore in the skin. Genes that determine sweat gland structure and function are largely unidentified. Read More

    Inflammatory and glandular skin disease in pregnancy.
    Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
    A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More

    Fox-Fordyce disease of the vulva.
    Indian J Sex Transm Dis 2016 Jan-Jun;37(1):65-7
    Department of Dermatology, Venereology and Leprosy, Saveetha Medical College and Hospital, Kancheepuram, Tamil Nadu, India.
    Fox-Fordyce disease is a rare, chronic skin disorder which affects the apocrine areas. This disease is due to the obstruction of the apocrine sweat duct. Extragenital regions are commonly affected than the genital region. Read More

    Fox-Fordyce Disease: An under-diagnosed adverse event of laser hair removal?
    J Eur Acad Dermatol Venereol 2016 Sep 2;30(9):1578-82. Epub 2016 May 2.
    Division of Dermatology, St Georges University Hospital, Beirut, Lebanon.
    Background: Fox-Fordyce Disease (FFD) is a rare chronic inflammatory skin disease of the apocrine glands, mainly affecting post-pubertal women. It involves apocrine gland-bearing areas including the axilla, areola, anogenital area and umbilicus. FFD induced by laser hair removal is a newly reported entity of unknown pathogenesis. Read More

    Successful treatment of areolar Fox-Fordyce disease with surgical excision and 1550-nm fractionated erbium glass laser.
    Int Wound J 2016 Oct 12;13(5):1016-9. Epub 2016 Apr 12.
    Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Republic of Korea.
    Fox-Fordyce disease (FFD) is a rare chronic disorder characterised by persistent inflammation because of the obstruction of apocrine sweat glands, which is a key factor of pathogenesis. The treatment of FFD is known to be difficult, and the modalities of treatment have not yet been widely studied. We report the successful treatment of a case of bilateral areolar FFD by a combination of surgical excision and 1550-nm fractionated erbium glass laser in an 18-year-old woman. Read More

    Clinical Effects of Topical Tacrolimus on Fox-Fordyce Disease.
    Case Rep Dermatol Med 2015 15;2015:205418. Epub 2015 Jun 15.
    Department of Pathology, Kırsehir Ahi Evran University, 40200 Kirsehir, Turkey.
    Fox-Fordyce Disease (FFD) is a rare, chronic, pruritic, inflammatory disorder of apocrine glands. It is characterized by dome-shaped, firm, discrete, skin-colored, and monomorphic perifollicular papules. The most common sites of involvement are axillae and anogenital and periareolar regions which are rich in apocrine sweat glands. Read More

    [UROLOGICAL ASPECTS OF THE FOX - FORDYCE DISEASE].
    Urologiia 2015 Jan-Feb(1):108-10
    The article presents the description of the clinical observation of the patient 28 years old with multiple granulomatous eruptions on the skin of the scrotum, accompanied by itching and pain when walking. Surgical treatment consisted of excising the skin of the scrotum and substitution dermatoplasty was performed. Fox - Fordyce disease was confirmed by histological examination of tissue removed: advanced cystic sebaceous gland duct with calcifications in its lumen was revealed. Read More

    Outcomes of anatomical versus functional testing for coronary artery disease.
    N Engl J Med 2015 Apr 14;372(14):1291-300. Epub 2015 Mar 14.
    From the Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D., M.R.P., D.B.M., H.R.A.-K., R.J.D., C.B.F., M.H., A.S.K., M.W.K., E.J.V., E.Y., K.L.L.); Massachusetts General Hospital, Harvard Medical School (U.H., M.H.P.), and Tufts Medical Center, Tufts University School of Medicine (J.E.U.) - both in Boston; New Mexico Heart Institute, Albuquerque (B.C.); Cardiology Associates, Mobile, AL (J.C.); North Dallas Research Associates, Dallas (M.A.K.); Cardiac Study Group, Puyallup, WA (V.M.); and the National Heart, Lung, and Blood Institute, Bethesda, MD (L.S.C.).
    Background: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care.

    Methods: We randomly assigned 10,003 symptomatic patients to a strategy of initial anatomical testing with the use of coronary computed tomographic angiography (CTA) or to functional testing (exercise electrocardiography, nuclear stress testing, or stress echocardiography). The composite primary end point was death, myocardial infarction, hospitalization for unstable angina, or major procedural complication. Read More

    Deciphering the functions of the hair follicle infundibulum in skin physiology and disease.
    Cell Tissue Res 2014 Dec 24;358(3):697-704. Epub 2014 Sep 24.
    Institute of Molecular Animal Breeding and Biotechnology Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany,
    The infundibulum is the funnel-shaped, uppermost epithelial segment of the hair follicle. Thus, as the infundibulum represents a major interface zone of mammalian skin epithelium with the environment and harbors a rich residential microflora, it is not surprising that this area is endowed with a specialized immune system and innate immune defenses. Clinically, the infundibulum is quite important, as it becomes prominently involved in many skin diseases such as acne, infundibular folliculitis and cysts, hidradenitis suppurativa, keratosis pilaris, Fox-Fordyce disease, and a subtype of basal cell carcinoma. Read More

    Fox Fordyce disease as a secondary effect of laser hair removal.
    J Cosmet Laser Ther 2014 Jun 18;16(3):141-3. Epub 2013 Nov 18.
    Department of Dermatology, Clinic University of Navarra , Pamplona , Spain.
    Fox Fordyce disease (FFD) has been recently described as an adverse effect of laser hair removal. It is an apocrine gland disorder characterized by pruritus and a folliculocentric papular eruption in apocrine sweat gland areas. Different etiologies have been proposed to be the cause of this entity. Read More

    Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis.
    Dermatol Online J 2013 Jun 15;19(6):18558. Epub 2013 Jun 15.
    Weill Cornell Medical College, New York, NY, USA.
    Hidradenitis suppurativa (HS), a pathologic follicular disease, impacts patients' lives profoundly and usually occurs in isolation. The diseases with the strongest association are obesity, depression, and pain. HS is associated with many diseases including acne conglobata (AC), dissecting cellulitis, pilonidal cysts, and obesity. Read More

    Fox-Fordyce-like disease following laser hair removal appearing on all treated areas.
    Lasers Med Sci 2013 Jul 15;28(4):1205-7. Epub 2013 Jan 15.
    Dermatology Department, Hôtel-Dieu de France Hospital, Beirut, Lebanon.
    Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. Read More

    Fox-Fordyce disease.
    Dermatol Online J 2012 Dec 15;18(12):28. Epub 2012 Dec 15.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
    Fox-Fordyce disease (FFD) is a rare inflammatory disorder that affects the apocrine sweat glands. Clinically, lesions are equidistant, smooth, uniform, firm, folliculocentric papules, which can range in color from flesh-colored to red-brown to slightly yellow. Whereas the axillae are most commonly involved, FFD also can involve the anogenital and periareolar areas, lips, umbilicus, sternum, perineum, and upper medial aspects of the thighs. Read More

    Rare sweat gland tumors of vulva: Report of two cases.
    Indian J Sex Transm Dis 2012 Jul;33(2):124-7
    Department of Skin and V.D, SBKS Medical College, Piparia, Waghodia, Baroda, Gujarat, India.
    Syringomas and Fox-Fordyce disease are appendageal skin disorders. While syringomas represent an adenoma of the intraepidermal eccrine duct, Fox Fordyce disease occurs due to blockage of the apocrine sweat duct. In both conditions, extragenital sites are more frequently involved than the genitalia. Read More

    Histopathology attributes of Fox-Fordyce disease.
    Int J Dermatol 2012 Nov;51(11):1313-8
    Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico.
    Background: Fox-Fordyce disease is a rare chronic papular condition with a very characteristic clinical presentation but a nonspecific histopathology. Its traditionally described histopathologic features have been criticized as variable and indistinct. Recently, a perifollicular infiltrate of histiocytes with foamy cytoplasm has been described as a consistent and reliable diagnostic finding. Read More

    Clinical effects of topical pimecrolimus in a patient with Fox-Fordyce disease.
    Australas J Dermatol 2012 May 9;53(2):e34-5. Epub 2010 Nov 9.
    Institute of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia.
    Fox-Fordyce disease (FFD) is characterized by a pruritic eruption of skin-coloured or yellowish papules in areas rich in apocrine glands. The histology comprises dilatation of follicular infundibula with hyperkeratosis, acanthosis, and spongiosis of the infundibular epithelium with perifollicular infiltration of lymphocytes and foamy histiocytes. We treated a 12-year-old girl with FFD with topical pimecrolimus for 12 weeks, this resulted in a complete clearance of lesions. Read More

    Fox-Fordyce disease: response to adapalene 0.1%.
    An Bras Dermatol 2012 Mar-Apr;87(2):329-31
    Dermatology Service of the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
    The Fox-Fordyce disease is a rare inflammatory dermatosis that affects mainly young women and is characterized by multiple follicular papules, skin color or brownish, very itchy, localized in areas rich in apocrine glands. Histopathology shows focal spongiosis of the upper infundibulum with fibrosis and perifollicular lymphohistiocytic infiltrate. The diagnosis is based on clinical and histopathological examination. Read More

    Fox-Fordyce disease following axillary laser hair removal.
    Arch Dermatol 2011 May;147(5):573-6
    Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce St, 2 Maloney Building, Philadelphia, PA 19104, USA.
    Background: Fox-Fordyce disease (FFD) is a relatively rare entity with a typical clinical presentation. Numerous studies have described unifying histopathological features of FFD, which together suggest a defect in the follicular infundibulum resulting in follicular dilation with keratin plugging, subsequent apocrine duct obstruction, and apocrine gland dilation, with eventual extravasation of the apocrine secretions as the primary histopathogenic events in the evolution of the disease.

    Observations: We describe a case of FFD that developed in a 41-year-old woman 3 months after completing a series of axillary laser hair removal treatments, and we detail the clinical and histopathological changes typical for FFD. Read More

    Fox-Fordyce disease exacerbated by hyperhidrosis.
    Pediatr Dermatol 2010 Mar-Apr;27(2):162-5
    University of California, Davis, School of Medicine, CA, USA.
    Fox-Fordyce disease is an uncommon disorder primarily affecting postpubertal females. It is characterized by intensely pruritic, papular eruptions in apocrine-gland bearing regions. Rarity and scant literature have resulted in a lack of definitive treatment options or pathognomonic diagnostic indicators. Read More

    Clinicopathological study of Fox-Fordyce disease.
    J Dermatol 2009 Sep;36(9):485-90
    School of Medicine, National Taiwan University, Taipei, Taiwan.
    Fox-Fordyce disease (FFD) is a rare skin disease manifesting as multiple pruritic follicular papules involving the skin-bearing apocrine glands. Reports of FFD in Asian people are scant. In this retrospective study, we describe the clinicopathological findings of five cases of FFD affecting Taiwanese subjects. Read More

    Dilation of apocrine glands. A forgotten but helpful histopathological clue to the diagnosis of axillary Fox-Fordyce disease.
    Am J Dermatopathol 2009 Jun;31(4):393-7
    Department of CIPAX-Medicina Diagnostica, Sao Jose dos Campos-SP, Brazil.
    Fox-Fordyce disease is a condition with protean histopathological alterations whose pathogenesis remains a mystery. Although recent studies have addressed histological changes specific of this disease, including perifollicular xanthomatosis, no attention has been given to apocrine acini dilation as an adjunct histopathological finding to the diagnosis. Moreover, although previous efforts were done to demonstrate that perifollicular foamy histiocytes harbor apocrine secretion content, this concept has not been proved to date. Read More

    Perifollicular xanthomatosis as the hallmark of axillary Fox-Fordyce disease: an evaluation of histopathologic features of 7 cases.
    Arch Dermatol 2008 Aug;144(8):1020-4
    Section of Dermatopathology, Department of Pathology, University of California, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA.
    Background: Fox-Fordyce disease (FFD) or apocrine miliaria is a rare condition with features that are characteristic clinically but not histopathologically. It is traditionally described as a condition that shows infundibular plugging, acanthosis, parakeratosis, spongiosis, and a nonspecific infiltrate. The so-called retention vesicle, which reputedly involves the apocrine duct, is often difficult to find. Read More

    [Perifollicular xanthomatosis as a key histological finding in Fox-Fordyce disease].
    Actas Dermosifiliogr 2008 Mar;99(2):145-8
    Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
    Fox-Fordyce disease is a rare skin condition characterized by the presence of multiple pruritic follicular papules in areas rich in apocrine glands, such as the axillae, mammary areolae, or genital regions. There is a high degree of variability in the histological findings seen in Fox-Fordyce disease. In addition to those described as typical of this entity, such as dilation of the infundibulum and hyperkeratosis and spongiosis of the infundibular epithelium, many other histological changes can be observed. Read More

    Patterns histopathologic of Fox-Fordyce disease.
    Am J Dermatopathol 2004 Dec;26(6):482-92
    Dermatologikum Hamburg, 20354 Hamburg, Germany.
    Fox-Fordyce disease is an uncommon condition that is biopsied even less commonly. Since the publication of Shelley and Levy, in 1956, the disease is regarded widely to be "apocrine miliaria", an analogue of eccrine miliaria. Histopathologically, an "intraepidermal sweat retention vesicle" is considered the only feature diagnostic of the condition. Read More

    Axillary perifollicular xanthomatosis resembling Fox-Fordyce disease.
    Australas J Dermatol 2004 May;45(2):146-8
    Skin and Cancer Foundation Australia, 277 Bourke Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
    A 40-year-old woman presented with a 2-year history of intermittently pruritic pale yellow follicular papules localized to both axillae associated with decreased axillary hair growth and sweating. Skin biopsies revealed an expanded perifollicular adventitial sheath packed with xanthoma cells. There was scant lymphocytic inflammation around the follicles. Read More

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