171 results match your criteria Fox-Fordyce Disease
An Bras Dermatol 2018 Jul-Aug;93(4):562-565
Clínica Dermatológica Valdés - León, Guanajuato, Mexico.
Fox-Fordyce disease is a relatively infrequent pathology of the apocrine glands that affects almost exclusively young women. The disease is characterized by the presence of pruritic follicular papules mainly in the armpits that respond poorly to treatment and severely affect the patient's quality of life. We report two cases with clinical diagnosis and histopathological confirmation, presenting perifollicular xanthomatosis on histological examination, recently described as a distinctive, consistent, and specific feature of this disease. Read More
Adv Biomed Res 2018 24;7:71. Epub 2018 Apr 24.
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
An Bras Dermatol 2018 Jan-Feb;93(1):161-162
Department of Dermatology, China-Japan Friendship Hospital - Beijing, China.
Hautarzt 2018 Apr;69(4):313-315
Universitäts-Hautklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
Fox-Fordyce disease (FFD), also known as apocrine miliaria, is a rare and chronic skin disease characterized by itching and skin-colored, light brown or yellowish papules. FFD typically affects postpubertal young women between 13 and 35 years. The etiology is not completely known, but a hormonal component is in discussion. Read More
Pol J Pathol 2017;68(4):277-283
President of prewar Lvov and Polish Republic on Exile, associate professor Stanisław Ostrowski was a dermatologist with a keen interest in dermatopathology. This study was based on original resources, which - mainly reports of his own authorship - were focused on dermatopathology. Stanisław Ostrowski provided excellent description of naevus epitheliomatosus sebaceus Wolters-Friboes both in Polish and German to be cited after decades in renowned handbooks of dermatopahtology published by Springer Verlag. Read More
Photodermatol Photoimmunol Photomed 2016 Sep 28;32(5-6):311-313. Epub 2016 Sep 28.
Department of Pathology, School of Medicine, Göztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
J Invest Dermatol 2017 01 1;137(1):38-45. Epub 2016 Sep 1.
Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Sweat glands are critical for thermoregulation. The single tubular structure of sweat glands has a lower secretory portion and an upper reabsorptive duct leading to the secretory pore in the skin. Genes that determine sweat gland structure and function are largely unidentified. Read More
Clin Dermatol 2016 May-Jun;34(3):335-43. Epub 2016 Feb 11.
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island.
A switch from cell-mediated to humoral immunity (helper T 1 [Th1] to helper T 2 [Th2] shift) during gestation plays a key role in placental immune tolerance. As a result, skin diseases that are Th2 mediated often worsen, whereas skin diseases that are Th1 mediated often improve during gestation. Also, due to fluctuations in glandular activity, skin diseases involving sebaceous and eccrine glands may flare, whereas those involving apocrine glands may improve during pregnancy. Read More
Eur J Dermatol 2016 Apr;26(2):212-3
Dpt of Dermatology, University of Franche Comté EA3181 and University Hospital, Besançon.
Indian J Sex Transm Dis AIDS 2016 Jan-Jun;37(1):65-7
Department of Dermatology, Venereology and Leprosy, Saveetha Medical College and Hospital, Kancheepuram, Tamil Nadu, India.
Fox-Fordyce disease is a rare, chronic skin disorder which affects the apocrine areas. This disease is due to the obstruction of the apocrine sweat duct. Extragenital regions are commonly affected than the genital region. Read More
J Eur Acad Dermatol Venereol 2016 Sep 2;30(9):1578-82. Epub 2016 May 2.
Division of Dermatology, St Georges University Hospital, Beirut, Lebanon.
Background: Fox-Fordyce Disease (FFD) is a rare chronic inflammatory skin disease of the apocrine glands, mainly affecting post-pubertal women. It involves apocrine gland-bearing areas including the axilla, areola, anogenital area and umbilicus. FFD induced by laser hair removal is a newly reported entity of unknown pathogenesis. Read More
Int Wound J 2016 Oct 12;13(5):1016-9. Epub 2016 Apr 12.
Department of Plastic and Reconstructive Surgery, The Catholic University of Korea, Seoul, Republic of Korea.
Fox-Fordyce disease (FFD) is a rare chronic disorder characterised by persistent inflammation because of the obstruction of apocrine sweat glands, which is a key factor of pathogenesis. The treatment of FFD is known to be difficult, and the modalities of treatment have not yet been widely studied. We report the successful treatment of a case of bilateral areolar FFD by a combination of surgical excision and 1550-nm fractionated erbium glass laser in an 18-year-old woman. Read More
JAAD Case Rep 2016 Jan 24;2(1):1-3. Epub 2015 Dec 24.
Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois.
J Dtsch Dermatol Ges 2016 Mar;14(3):340
Sultan Qaboos Univ Med J 2016 Feb 2;16(1):e119-20. Epub 2016 Feb 2.
Pathology, Virgen de las Nieves Hospital, Granada, Spain.
J Dtsch Dermatol Ges 2016 Jan;14(1):62-3
National Skin Centre, Singapore.
Indian Dermatol Online J 2015 Sep-Oct;6(5):376-7
Department of Dermatology, St. John's Medical College, Rajiv Gandhi university of health sciences, Bengaluru, Karnataka, India.
Br J Dermatol 2016 Feb 18;174(2):458-9. Epub 2015 Nov 18.
Department of Dermatology, La Paz University Hospital, Paseo La Castellana 261, Madrid, CP: 28046, Spain.
Case Rep Dermatol Med 2015 15;2015:205418. Epub 2015 Jun 15.
Department of Pathology, Kırsehir Ahi Evran University, 40200 Kirsehir, Turkey.
Fox-Fordyce Disease (FFD) is a rare, chronic, pruritic, inflammatory disorder of apocrine glands. It is characterized by dome-shaped, firm, discrete, skin-colored, and monomorphic perifollicular papules. The most common sites of involvement are axillae and anogenital and periareolar regions which are rich in apocrine sweat glands. Read More
Urologiia 2015 Jan-Feb(1):108-10
The article presents the description of the clinical observation of the patient 28 years old with multiple granulomatous eruptions on the skin of the scrotum, accompanied by itching and pain when walking. Surgical treatment consisted of excising the skin of the scrotum and substitution dermatoplasty was performed. Fox - Fordyce disease was confirmed by histological examination of tissue removed: advanced cystic sebaceous gland duct with calcifications in its lumen was revealed. Read More
Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):97-101
Department of Dermatology, Rajiv Gandhi Medical College, Thane, India.
Indian J Dermatol Venereol Leprol 2015 Jan-Feb;81(1):87-8
Department of Dermatology, Christian Medical College, Ludhiana, Punjab, India.
Cell Tissue Res 2014 Dec 24;358(3):697-704. Epub 2014 Sep 24.
Institute of Molecular Animal Breeding and Biotechnology Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany,
The infundibulum is the funnel-shaped, uppermost epithelial segment of the hair follicle. Thus, as the infundibulum represents a major interface zone of mammalian skin epithelium with the environment and harbors a rich residential microflora, it is not surprising that this area is endowed with a specialized immune system and innate immune defenses. Clinically, the infundibulum is quite important, as it becomes prominently involved in many skin diseases such as acne, infundibular folliculitis and cysts, hidradenitis suppurativa, keratosis pilaris, Fox-Fordyce disease, and a subtype of basal cell carcinoma. Read More
Actas Dermosifiliogr 2015 Jan-Feb;106(1):61-2. Epub 2014 May 13.
Servicio de Dermatología Médico-Quirúrgica, Hospital Universitario Quirón Madrid, Madrid, España.
Int J Dermatol 2013 Dec;52(12):1571-2
Division of Dermatology Department of Internal Medicine King Abdullah University Hospital Jordan University of Science and Technology Irbid Jordan.
J Cosmet Laser Ther 2014 Jun 18;16(3):141-3. Epub 2013 Nov 18.
Department of Dermatology, Clinic University of Navarra , Pamplona , Spain.
Fox Fordyce disease (FFD) has been recently described as an adverse effect of laser hair removal. It is an apocrine gland disorder characterized by pruritus and a folliculocentric papular eruption in apocrine sweat gland areas. Different etiologies have been proposed to be the cause of this entity. Read More
Dermatol Online J 2013 Jun 15;19(6):18558. Epub 2013 Jun 15.
Weill Cornell Medical College, New York, NY, USA.
Hidradenitis suppurativa (HS), a pathologic follicular disease, impacts patients' lives profoundly and usually occurs in isolation. The diseases with the strongest association are obesity, depression, and pain. HS is associated with many diseases including acne conglobata (AC), dissecting cellulitis, pilonidal cysts, and obesity. Read More
Lasers Med Sci 2013 Jul 15;28(4):1205-7. Epub 2013 Jan 15.
Dermatology Department, Hôtel-Dieu de France Hospital, Beirut, Lebanon.
Fox-Fordyce disease is an uncommon inflammatory disease of the apocrine sweat glands. Two recent reports indicated laser hair removal as a novel cause of axillary Fox-Fordyce disease. We report the first case of Fox-Fordyce disease developing in women after completing treatment with a depilatory hair laser appearing in the axillae, umbilicus, and pubis. Read More
Dermatol Online J 2012 Dec 15;18(12):28. Epub 2012 Dec 15.
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
Fox-Fordyce disease (FFD) is a rare inflammatory disorder that affects the apocrine sweat glands. Clinically, lesions are equidistant, smooth, uniform, firm, folliculocentric papules, which can range in color from flesh-colored to red-brown to slightly yellow. Whereas the axillae are most commonly involved, FFD also can involve the anogenital and periareolar areas, lips, umbilicus, sternum, perineum, and upper medial aspects of the thighs. Read More
Actas Dermosifiliogr 2013 Nov 20;104(9):832-4. Epub 2012 Dec 20.
Servicio de Dermatología, Hospital Universitario Sta. María del Rosell de Cartagena, Murcia, España. Electronic address:
Indian J Sex Transm Dis AIDS 2012 Jul;33(2):124-7
Department of Skin and V.D, SBKS Medical College, Piparia, Waghodia, Baroda, Gujarat, India.
Syringomas and Fox-Fordyce disease are appendageal skin disorders. While syringomas represent an adenoma of the intraepidermal eccrine duct, Fox Fordyce disease occurs due to blockage of the apocrine sweat duct. In both conditions, extragenital sites are more frequently involved than the genitalia. Read More
J Cutan Pathol 2012 Dec;39(12):1057-9
Department of Pathology, Keck School of Medicine of the University of Southern California, USA.
Int J Dermatol 2012 Nov;51(11):1313-8
Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico.
Background: Fox-Fordyce disease is a rare chronic papular condition with a very characteristic clinical presentation but a nonspecific histopathology. Its traditionally described histopathologic features have been criticized as variable and indistinct. Recently, a perifollicular infiltrate of histiocytes with foamy cytoplasm has been described as a consistent and reliable diagnostic finding. Read More
J Am Acad Dermatol 2012 Oct;67(4):e139-40
Australas J Dermatol 2012 May 9;53(2):e34-5. Epub 2010 Nov 9.
Institute of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia.
Fox-Fordyce disease (FFD) is characterized by a pruritic eruption of skin-coloured or yellowish papules in areas rich in apocrine glands. The histology comprises dilatation of follicular infundibula with hyperkeratosis, acanthosis, and spongiosis of the infundibular epithelium with perifollicular infiltration of lymphocytes and foamy histiocytes. We treated a 12-year-old girl with FFD with topical pimecrolimus for 12 weeks, this resulted in a complete clearance of lesions. Read More
An Bras Dermatol 2012 Mar-Apr;87(2):329-31
Dermatology Service of the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.
The Fox-Fordyce disease is a rare inflammatory dermatosis that affects mainly young women and is characterized by multiple follicular papules, skin color or brownish, very itchy, localized in areas rich in apocrine glands. Histopathology shows focal spongiosis of the upper infundibulum with fibrosis and perifollicular lymphohistiocytic infiltrate. The diagnosis is based on clinical and histopathological examination. Read More
J Pediatr Adolesc Gynecol 2011 Jun;24(3):108-9
Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Am Acad Dermatol 2011 Jul;65(1):229-30
Arch Dermatol 2011 May;147(5):573-6
Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce St, 2 Maloney Building, Philadelphia, PA 19104, USA.
Background: Fox-Fordyce disease (FFD) is a relatively rare entity with a typical clinical presentation. Numerous studies have described unifying histopathological features of FFD, which together suggest a defect in the follicular infundibulum resulting in follicular dilation with keratin plugging, subsequent apocrine duct obstruction, and apocrine gland dilation, with eventual extravasation of the apocrine secretions as the primary histopathogenic events in the evolution of the disease.
Observations: We describe a case of FFD that developed in a 41-year-old woman 3 months after completing a series of axillary laser hair removal treatments, and we detail the clinical and histopathological changes typical for FFD. Read More
Pediatr Dermatol 2010 Mar-Apr;27(2):162-5
University of California, Davis, School of Medicine, CA, USA.
Fox-Fordyce disease is an uncommon disorder primarily affecting postpubertal females. It is characterized by intensely pruritic, papular eruptions in apocrine-gland bearing regions. Rarity and scant literature have resulted in a lack of definitive treatment options or pathognomonic diagnostic indicators. Read More
J Dermatol 2009 Sep;36(9):485-90
School of Medicine, National Taiwan University, Taipei, Taiwan.
Fox-Fordyce disease (FFD) is a rare skin disease manifesting as multiple pruritic follicular papules involving the skin-bearing apocrine glands. Reports of FFD in Asian people are scant. In this retrospective study, we describe the clinicopathological findings of five cases of FFD affecting Taiwanese subjects. Read More
Am J Dermatopathol 2009 Jun;31(4):393-7
Department of CIPAX-Medicina Diagnostica, Sao Jose dos Campos-SP, Brazil.
Fox-Fordyce disease is a condition with protean histopathological alterations whose pathogenesis remains a mystery. Although recent studies have addressed histological changes specific of this disease, including perifollicular xanthomatosis, no attention has been given to apocrine acini dilation as an adjunct histopathological finding to the diagnosis. Moreover, although previous efforts were done to demonstrate that perifollicular foamy histiocytes harbor apocrine secretion content, this concept has not been proved to date. Read More
Dermatology 2009 5;218(2):176-7. Epub 2008 Dec 5.
Arch Dermatol 2008 Aug;144(8):1020-4
Section of Dermatopathology, Department of Pathology, University of California, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA.
Background: Fox-Fordyce disease (FFD) or apocrine miliaria is a rare condition with features that are characteristic clinically but not histopathologically. It is traditionally described as a condition that shows infundibular plugging, acanthosis, parakeratosis, spongiosis, and a nonspecific infiltrate. The so-called retention vesicle, which reputedly involves the apocrine duct, is often difficult to find. Read More
Dermatol Online J 2008 Apr 15;14(4):13. Epub 2008 Apr 15.
Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.
Syringomas are common benign neoplasms encountered mostly around the eyes. However, as described herein, these tumors can occur in atypical locations such as the axilla. The differential diagnosis revolves around those entities more likely seen in this anatomical location (such as Fox-Fordyce, Hailey-Hailey and Darier diseases). Read More
Am Fam Physician 2008 Jun;77(12):1735-6
Regional Support Organization, Norfolk, Virginia, USA.
Actas Dermosifiliogr 2008 Mar;99(2):145-8
Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
Fox-Fordyce disease is a rare skin condition characterized by the presence of multiple pruritic follicular papules in areas rich in apocrine glands, such as the axillae, mammary areolae, or genital regions. There is a high degree of variability in the histological findings seen in Fox-Fordyce disease. In addition to those described as typical of this entity, such as dilation of the infundibulum and hyperkeratosis and spongiosis of the infundibular epithelium, many other histological changes can be observed. Read More