Search Our Scientific Publications & Authors

AACN Adv Crit Care 2022 Jun;33(2):165-172

Holly Kirkland-Kyhn is Director of Wound Care, University of California, Davis Medical Center, Sacramento, California.

Critically ill patients are at high risk for organ failure, including that of the integumentary system. Nurses working in intensive care are adept at performing comprehensive assessments that include the skin. Although pressure injury is a well-known complication associated with critical illness, patients may also have debilitating and life-threatening dermatoses. Read More

Ann Med Surg (Lond) 2022 May 9;77:103595. Epub 2022 Apr 9.

Department of Anesthesiology and Critical Care Medicine, Shree Birendra Hospital, Chhauni, Kathmandu, 44600, Nepal.

Introduction And Importance: Retroperitoneal extension is a rare and fatal complication of Fournier's gangrene (FG) which mandates immediate surgical intervention for better outcome.

Case Presentation: A 70-year-old male presented to the emergency department with a history of bilateral painful scrotal swelling for 7 days with fever and abdominal pain for 3 days. On his general examination, he was septic with necrotic patches in the perineum and bilateral scrotum. Read More

Int J Environ Res Public Health 2022 05 21;19(10). Epub 2022 May 21.

Obstetrics and Gynecology, Materno-Infantil Hospital Regional Universitario Malaga, Avd Arroyo de los Angeles S/N, 29011 Malaga, Spain.

Fournier's gangrene (FG) is a serious pathology of the soft tissues and fascia of the perineum and genital region with a high morbidity and mortality rate. In recent years, the SGLT-2 inhibitor oral antidiabetic has been related to this entity. According to the new warnings from the main drug agencies, a compilation of cases has been initiated to establish or deny a possible causal relationship. Read More

Ann Coloproctol 2022 May 26. Epub 2022 May 26.

Department of General Surgery, Bendigo Health, Bendigo, Australia.

Purpose: A patient presented to a regional surgical center with Fournier gangrene (FG) and concurrent multifocal necrotizing fasciitis (NF). Given the rarity, it was decided to undertake a systematic review to investigate the incidence and prevalence of FG with multifocal NF and consequently determine the treatment and approach to management of such presentation.

Methods: Firstly, the report of the 56-year-old male patient is discussed regarding his surgical management. Read More

Int J Infect Dis 2022 May 20;122:222-229. Epub 2022 May 20.

Department of Plastic and Burn Surgery, the Second People's Hospital of Yibin (the Yibin Hospital of West China Hospital, Sichuan University), Sichuan, China.

Objectives: In this study, we aimed to illustrate distinctions between Fournier's gangrene (FG) and lower extremity necrotising fasciitis (NF) and screen out possible risk factors of poor prognosis for each cohort.

Methods: The medical records of qualified patients with NF admitted to the Second People's Hospital of Yibin from January 2016 to June 2021 were retrospectively reviewed. All participants were anatomically categorised into FG and lower extremity NF groups, and their baseline data and microbiological results were compared. Read More

Int Braz J Urol 2022 May 10;48. Epub 2022 May 10.

Department of Urology, Faculty of Medicine, Universitas Airlangga, Universitas Airlangga Teaching Hospital, Surabaya, East Java, Indonesia.

Purpose: Management of Fournier's Gangrene (FG) includes broad-spectrum antibiotics with adequate surgical debridement, which should be performed within the first 24 hours of onset. However, this treatment may cause significant loss of tissue and may delay healing with the presence of ischemia. Hyperbaric oxygen therapy (HBOT) has been proposed as adjunctive therapy to assist the healing process. Read More

Urology 2022 May 15. Epub 2022 May 15.

University of Iowa, Carver College of Medicine, Department of Urology. Electronic address:

Objective: To evaluate the efficacy of early necrotizing soft-tissue infections of the genitalia (NSTIG) component separation, primary wound closure (CSC). We hypothesized that early CSC would be safe, decrease the need for split-thickness skin grafting (STSG) and decrease wound convalescence time.

Materials/methods: Management of consecutive NSTIG patients from a single institution were evaluated. Read More

Gan To Kagaku Ryoho 2022 May;49(5):597-599

Dept. of Medical Oncology, Tokyo Saiseikai Central Hospital.

A 52-year-old man diagnosed with Stage ⅢA rectal and anal canal cancer underwent abdominal perineal resection using Miles's method. Two years later, local recurrence and lung metastases were detected using contrasted CT imaging. First-line chemotherapy of XELOX was administered for 4 months until the disease progressed and lung metastases developed. Read More

Int J Surg Open 2022 Jun 11;43:100488. Epub 2022 May 11.

Department of Surgery, University Hospital Limerick, Ireland.

Necrotising fasciitis (NF) is a severe soft tissue infection that is associated with a high risk of morbidity and mortality. During the coronavirus disease 19 (COVID-19) pandemic, the population has been actively discouraged from presenting to emergency medical services unless absolutely necessary. While this was an important step in allowing for preservation of limited resources in a time of crisis, it may have resulted in immeasurable 'secondary victims' of the pandemic as patients with time-critical conditions delay hospital presentation. Read More

Sisli Etfal Hastan Tip Bul 2022 28;56(1):49-54. Epub 2022 Mar 28.

Department of Urology, University of Health Sciences Turkey, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey.

Objectives: We aimed to reveal the change of urological emergencies during the COVID-19 pandemic compared to the same period of the previous year.

Methods: The number of admissions to the emergency department (ED), admissions to the urology outpatient clinic, emergency urological consultations, and urological and emergency urological surgeries during the periods April-November-2019 and April-November-2020 were recorded. The data of the COVID-19 period were compared with the previous year. Read More

Ulus Travma Acil Cerrahi Derg 2022 Apr;28(4):490-497

Ankara Numune Training and Research Hospital, Department of General Surgery, Ankara-Turkey.

Background: Many predictive factors and scoring systems associated with Fournier's gangrene have been proposed, including comorbidities, vital signs, biochemical and hematological parameters, and demographic characteristics of the patient. The aim of this study was to determine the strengths of the scoring systems that have been formed by revealing these factors from a wider perspective and in a larger patient population.

Methods: The patient population included 144 patients, 21 of whom died. Read More

Front Surg 2022 6;9:850378. Epub 2022 Apr 6.

Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.

Purpose: In Fournier's gangrene, surgical debridement plus antimicrobial therapy is the mainstay of treatment but can cause a great loss of tissue. The disease needs long hospital stays and, despite all, has a high mortality rate. The aim of our study is to investigate if factors, such as hyperbaric therapy, can offer an improvement in prognosis. Read More

Diagnostics (Basel) 2022 Mar 31;12(4). Epub 2022 Mar 31.

Clinical-Medical Department, Faculty of Medicine and Pharmacy, Dunărea de Jos University of Galati, 800201 Galati, Romania.

In this article, we present the case of a patient who hid the real reason for which he came to the emergency room. This patient in this case is a 61-year-old man, who presented to the emergency department for symptoms relevant to respiratory disease. However, the initial diagnosis turned out to be only the "tip of the iceberg" in the evolution and treatment of this patient. Read More

Clin Case Rep 2022 Apr 18;10(4):e05747. Epub 2022 Apr 18.

Surgery Department Kamenge Teaching Hospital University of Burundi Bujumbura Burundi.

Fournier's gangrene, a rapidly progressive necrotizing fasciitis of the perineum and external genitalia that leads to extensive soft tissue necrosis, remains a medical-surgical emergency. The authors present a case of coverage of a scrotal loss of substance with testicular exposure by a medial fasciocutaneous flap of the unilateral thigh after debridement and initial medical treatment of Fournier's gangrene in a 50-year-old quadriplegic patient. The clinical examination at 8 months showed an aesthetic and functional result. Read More

Int J Surg Case Rep 2022 May 30;94:106982. Epub 2022 Mar 30.

Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Introduction And Importance: Fournier's gangrene is necrotizing fasciitis of the scrotum and perineal area. It is a polymicrobial infection of perianal origin characterized by rapid necrotizing spread along fascial planes to abdominal wall and flank area. The very rare nature of this illness in neonates makes it important to take a lesson in subsequent management of similar cases. Read More

Surg Infect (Larchmt) 2022 05 7;23(4):411-412. Epub 2022 Apr 7.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Am J Case Rep 2022 Mar 24;23:e934942. Epub 2022 Mar 24.

Colorectal Surgery Division, Department of Gastroenterology, Hospital das Clinicas HCFMUSP, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

BACKGROUND Fournier's gangrene (FG) is a rapidly progressive necrotizing infection of the perineum. Risk factors include male sex and immunosuppression. Inflammatory bowel disease and pregnancy may alter immune response by complex mechanisms but have rarely been associated with necrotizing infections of the perineum. Read More

Drugs Context 2022 17;11. Epub 2022 Feb 17.

Unidad de Diabetes y Obesidad, Hospital Vithas Sevilla, Sevilla, Spain.

Background: This study aims to evaluate dapagliflozin in patients with type 2 diabetes (T2D) in clinical practice in Spain.

Methods: This is a retrospective study including adults with T2D under stable antidiabetic therapy, with either dapagliflozin or sitagliptin ≥6 months, before inclusion. Data about the effectiveness and safety of dapagliflozin are presented. Read More

Cureus 2022 Jan 25;14(1):e21612. Epub 2022 Jan 25.

Urology, New Jersey Urology, Voorhees, USA.

Fournier's gangrene and emphysematous pyelonephritis are rare necrotizing infections of the genitourinary system. Many cases of this rapidly progressive infection occur from abscesses and urinary tract infections; however, Fournier's gangrene secondary to emphysematous pyelonephritis is seldom discussed in the literature. Emphysematous pyelonephritis is defined as a gas-forming, necrotizing infection of the renal parenchyma or its surrounding tissue. Read More

BMC Urol 2022 Feb 23;22(1):25. Epub 2022 Feb 23.

Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.

Background: Fournier's gangrene (FG), a urological emergency with high mortality, is an infectious necrotizing fasciitis of the perineal and genital regions. The majority of FG is caused by polymicrobial organisms involving mixed aerobes and anaerobes but rarely reveals Actinomyces species.

Case Presentation: We report a healthy 67-year-old Asian male who presented with rapidly progressive painful swelling of the scrotum. Read More

Am J Case Rep 2022 Feb 23;23:e935250. Epub 2022 Feb 23.

Division of Dermatology, Department of Internal Medicine, BronxCare Health System, Bronx, NY, USA.

BACKGROUND Cocaine is a highly addictive drug and its use has increased in recent years. It is the second most popular illicit drug in the United States and is the second most trafficked illicit drug in the world. Intravenous (i. Read More

Surg Infect (Larchmt) 2022 Apr 21;23(3):304-312. Epub 2022 Feb 21.

Department of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Necrotizing soft tissue infections (NSTIs) are severe, rapidly spreading infections with high morbidity and mortality. Attempts to identify risk factors for mortality and morbidity have produced variable results. We hope to determine which factors across the NSTI population impact mortality, morbidities, and discharge disposition. Read More

Cureus 2022 Jan 14;14(1):e21229. Epub 2022 Jan 14.

General Medicine, St. John's Medical College Hospital, Bangalore, IND.

Mucormycosis is a rare opportunistic fungal infection commonly affecting immunocompromised individuals. There has been a surge in the number of these cases during the second wave of the Coronavirus Disease 2019 (COVID-19) in India. Mucormycosis has been reported to occur concurrently or a few weeks post-recovery from COVID-19. Read More

J Emerg Med 2022 04 31;62(4):480-491. Epub 2022 Jan 31.

Department of Emergency Medicine, Virginia Tech Carilion School of Medicine, Roanoke, Virginia.

Background: Skin and soft tissue infections are common emergency department (ED) presentations. These infections cover a wide spectrum of disease, from simple cellulitis to necrotizing fasciitis. Despite the commonality, a subset of skin and soft tissue infections known as necrotizing soft tissue infections (NSTIs) can cause significant morbidity and mortality. Read More

Ann Coloproctol 2022 Feb 3. Epub 2022 Feb 3.

Division of Colorectal Surgery, Department of General Surgery, Çukurova University Faculty of Medicine, Adana, Turkey.

Purpose: This study aimed to determine the C-reactive protein (CRP) ratio for the survival of patients with Fournier gangrene (FG).

Methods: Fifty-two patients with FG between January 2011 and September 2018 were retrospectively analyzed. Data on clinical presentation, Fournier Gangrene Severity Index (FGSI), CRP ratio, management, and outcome were analyzed. Read More

Radiol Case Rep 2022 Mar 18;17(3):959-962. Epub 2022 Jan 18.

Department of Radiology, Mogadishu Somali Turkey, Recep Tayyip Erdogan Training and Research Hospital, Mogadishu, Somalia.

Necrotizing fasciitis and/or Fournier's Gangrene is a rare, life-threatening soft tissue infection that, if not treated promptly, can immediately develop into systemic toxicity. It affects the genital, perineal, and perineal tissues, predominantly affecting men but can be seen in women. The diagnosis is often made clinically but radiologic examinations are helpful to determine the extent of the infection and can aid preoperative planning. Read More

Ulus Travma Acil Cerrahi Derg 2022 Jan;28(2):155-161

Department of General Surgery, Afyonkarahisar Health Sciences University, Afyonkarahisar-Turkey.

Background: Fournier gangrene (FG) is a rapidly progressive soft-tissue necrosis that may be life-threating unless aggressive treatment is applied immediately. FG severity index was described first by Laor et al. to predict mortality rate but there are few studies on the prognostic significance of FG severity index and especially the microbial agents isolated from debridement on patient prognosis. Read More

Urol Case Rep 2022 Mar 24;41:101985. Epub 2021 Dec 24.

Department of Basic Medical Sciences, School of Medicine, University of Health and Allied Sciences, Ho, Ghana.

Primary anterior urethral calculi account for <0.3% of urinary stones with over 90% resulting from luminal anomalies. These stones are often diagnosed early and treated without clinical problems. Read More

Ulus Travma Acil Cerrahi Derg 2022 Jan;28(1):48-56

Department of Urology, Harran University Faculty of Medicine, Şanlıurfa-Turkey.

Background: This study aims to examine the factors affecting the selection of anaesthesia method in Fournier's gangrene.

Methods: A retrospective evaluation was made of 113 patients operated on because of Fournier's gangrene between January-May 2019. The operations were performed under spinal anaesthesia in 78 cases (Group S) and under general anaesthesia in 35 cases (Group G). Read More

Urologiia 2021 Dec(6):124-126

Siberian State Medical University of the Ministry of Health of Russia Siberian State Medical University Tomsk, Russia.

Gangrene of the penis is a rare condition manifesting with purulent necrotization of penile tissues and systemic inflammatory response. In more than 90% of cases, the cause of the development of the penile and scrotal gangrene is rapidly progressive necrotizing fasciitis of polymicrobial etiology, which predominantly affected the external genital organs. Isolated cases of penile gangrene development when using the restraining rings of the penis are described in literature (condom urine collection bag, rings for erection, etc. Read More