2,727 results match your criteria Fortschritte der Neurologie-Psychiatrie [Journal]


[Alternative Psychoses and Forced Normalization after Seizure Control by Anticonvulsants with Special Consideration of the New Anticonvulsants].

Fortschr Neurol Psychiatr 2019 Feb 20. Epub 2019 Feb 20.

Zentrum für Psychiatrie Südwürttemberg, Klinik für Psychiatrie und Psychotherapie I, Universität Ulm.

In the case of alternative psychosis and forced normalization, the patient alternates between periods of clinically manifest seizures and normal behavior, and other periods of seizure freedom (or significant seizure reduction) accompanied by psychosis or behavioral disturbances. Unlike the clinically defined alternative psychosis, forced normalization is based on EEG findings. In clinical practice and in the literature, both terms are mostly used synonymously, and they also describe the same clinical pictures. Read More

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http://dx.doi.org/10.1055/a-0820-3345DOI Listing
February 2019

[Advance research directives in the context of dementia research: Ethical reflections on the disclosure requirement].

Fortschr Neurol Psychiatr 2019 Feb 20. Epub 2019 Feb 20.

Ruhr-Universität Bochum, Medizinische Fakultät, Institut für medizinische Ethik und Geschichte der Medizin.

In November 2016, the German Federal Diet adopted an amendment to the German Medicinal Products Act (Arzneimittelgesetz), which permits non-therapeutic biomedical research on incompetent adults under a number of strict conditions. One of these conditions is that the potential research participant has declared her wish to participate in biomedical research in a valid research advance directive. Before completing the research advance directive, the potential research participant must be informed about the circumstances of research participation. Read More

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http://dx.doi.org/10.1055/a-0664-7980DOI Listing
February 2019

[The CIMH Track Concept in Psychiatry: Syndrome-specific Treatment across Modalities - Part 1 - Theoretical background].

Fortschr Neurol Psychiatr 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland.

During the past decades, important progress was made in the treatment of patients with mental disorders. Nevertheless, the guideline-based treatment still represents a significant challenge that must take into account novel diagnostic and therapeutic possibilities as well as recent social development and the economic framework. Therefore, there is a need for further improvement of care in inpatient, day-care and outpatient hospital units. Read More

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http://dx.doi.org/10.1055/a-0759-1859DOI Listing
February 2019

[The CIMH Track Concept in Psychiatry: Syndrome-specific Treatment across Modalities - Part 2 - Practical implementation].

Fortschr Neurol Psychiatr 2019 Feb 7. Epub 2019 Feb 7.

Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland.

Modern psychiatry needs to implement novel mental health care systems in order to address recent developments in diagnostics and treatment of psychiatric patients. In this context, it is necessary to take into account recent ethical and certain legal aspects which explicitly seek to reduce coercive treatment. The so-called "track-unit" is a promising strategy in order to achieve these goals. Read More

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http://dx.doi.org/10.1055/a-0759-1957DOI Listing
February 2019

[Duplex Sonography of the Brain-Supplying Arteries - Pitfalls].

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):718-730. Epub 2019 Jan 17.

This CME article presents a structured examination of duplex sonography of the brain-supplying arteries, especially focusing on difficulties and pitfalls. Criteria for stenosis grading and common mistakes as well as anatomical and methodical characteristics are described in detail. Read More

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http://dx.doi.org/10.1055/a-0749-5862DOI Listing
November 2018
1 Read

Tako-Tsubo Cardiomyopathy during a series of Electroconvulsive Therapy (ECT) applications: A case report, systematic literature research and discussion of specific risk factors.

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):699-710. Epub 2019 Jan 17.

Universitätsklinikum Köln, Klinik und Poliklinik für Psychiatrie und Psychotherapie.

Background: Tako-Tsubo Cardiomyopathy (TTC) is an acute, reversible disease of the myocardium. It seems to be caused by an excess of epinephrine, norepinephrine and dopamine. Psychological or physiological stress is considered as a risk factor. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0653-7063
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http://dx.doi.org/10.1055/a-0653-7063DOI Listing
November 2018
7 Reads

[Cognitive deficits associated with electroconvulsive therapy for depression: moderating factors and neuropsychological tests].

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):690-698. Epub 2019 Jan 17.

Klinik und Poliklinik für Psychiatrie und Psychotherapie Heinrich-Heine-Universität, Medizinische Fakultät, Düsseldorf.

Due to the efficacy of electroconvulsive therapy (ECT) in the guideline-based treatment of therapy-resistant depressive episodes and the clinical significance of cognitive impairments, it is necessary to optimize the management of potential side effects. As cognitive side effects of the treatment combined with impairments resulting from the depression may lead to a reduction in the ability to function in social contexts and reduce subjective wellbeing, comprehensive information about and monitoring of potential side effects is essential. In this review we present the clinical relevance and measurement of cognitive side effects that may occur during electroconvulsive therapy. Read More

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http://dx.doi.org/10.1055/a-0758-1387DOI Listing
November 2018
5 Reads

[Determinants of relapse after electroconvulsive therapy in depressed patients].

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):711-717. Epub 2019 Jan 17.

UK Aachen, Klinik für Psychiatrie, Psychotherapie und Psychosomatik.

Background: Maintaining remission after successful acute treatment remains a challenge in the use of electroconvulsive therapy (ECT). For this purpose, the concept of gradually tapered continuation ECT (C-ECT) has been increasingly propagated. The present study is aimed at identifying factors that contribute to relapse after ECT in depressed patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0762-0624
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http://dx.doi.org/10.1055/a-0762-0624DOI Listing
November 2018
7 Reads

Schwerpunktheft EKT.

Fortschr Neurol Psychiatr 2018 Nov 17;86(11):678-679. Epub 2019 Jan 17.

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http://dx.doi.org/10.1055/a-0681-8928DOI Listing
November 2018
1 Read

[Legal Capacity in patients with post-stroke-aphasia].

Fortschr Neurol Psychiatr 2018 Dec 7;86(12):770-777. Epub 2019 Jan 7.

Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg.

Aphasia is a frequent cognitive disorder after stroke. Despite a high prevalence, there is comparatively little medical literature or high court jurisdiction concerning the question if aphasia impairs patients in their legal capacity.Imaging studies allow a detailed understanding of the underlying pathology of aphasia, the resulting clinical pictures and potential mechanisms of recovery. Read More

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http://dx.doi.org/10.1055/a-0695-9104DOI Listing
December 2018
3 Reads

["Lithium in the treatment of old age depression. What are the pros and cons?"]

Fortschr Neurol Psychiatr 2018 Dec 7;86(12):754-762. Epub 2019 Jan 7.

Charité Universitätsmedizin Berlin Campus Benjamin Franklin.

Objective: Augmentation with lithium is one of the treatment options in therapy-resistant depression. This review presents the current data concerning the use of lithium in elderly patients with unipolar depression.

Method: Through a selective literature search in the database PubMed, 15 relevant articles were identified and included. Read More

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http://dx.doi.org/10.1055/a-0644-2578DOI Listing
December 2018
6 Reads

Die S2k-Leitlinie Notfallpsychiatrie.

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Fortschr Neurol Psychiatr 2018 Dec 7;86(12):742-743. Epub 2019 Jan 7.

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http://dx.doi.org/10.1055/a-0736-2084DOI Listing
December 2018
1 Read

[Work-related medical rehabilitation (WMR) in Neurology requires individualised rehabilitant identification].

Fortschr Neurol Psychiatr 2019 Jan 7. Epub 2019 Jan 7.

Dr. Becker Neurozentrum Niedersachsen Bad Essen.

To increase the rate of successful return-to-work (RTW) after acute or chronic diseases, the German Pension Insurance established the concept of work-related medical rehabilitation (WMR) as a strategic advancement of conventional medical rehabilitation. Although in some indications, the WMR is demonstrably superior to conventional medical rehabilitation in terms of occupational reintegration, this has not yet been proven for neurology so far. Current studies on neurological WMR point to the complexity of clinical anamnestic characteristics of the target group, which makes it difficult to define severe restrictions of work ability (SRWA) as a prerequisite for access to the neurological WMR. Read More

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http://dx.doi.org/10.1055/a-0695-9074DOI Listing
January 2019
1 Read

[The multifaceted concept of mental disorder].

Authors:
Heinz Häfner

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Zentralinstitut für Seelische Gesundheit, AG Schizophrenieforschung; Medizinische Fakultät Mannheim / Universität Heidelberg.

The concept of mental disorder has many facets. Specific concepts of disease or disorder stand for individual entities, classified as diagnoses. Ideally, they are based on discrete physical, neurobiological or - as is the case with hereditary diseases - genetic findings. Read More

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http://dx.doi.org/10.1055/a-0624-9456DOI Listing
December 2018
13 Reads

[Subjective memory impairments in early detection of dementia: Relation to acceptability of lumbar puncture in memory clinic patients].

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Vitos Klinikum Gießen-Marburg, Vitos Klinik für Psychiatrie und Psychotherapie Gießen; Fachbereich Medizin, Philipps-Universität Marburg.

Background: In memory clinics, biomarker-based diagnostic tools for early detection and differential diagnosis of dementia are increasingly important, even if their acceptance by patients is relatively low.

Objective: The aim of study was to examine whether sociodemographic and clinical features of memory clinic patients are associated with acceptance of lumbar puncture (LP). Of particular interest was the patients' self-perception of memory decline (subjective memory impairment, SMI) accompanied by related concerns that might affect decision to consent to LP. Read More

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http://dx.doi.org/10.1055/a-0644-2530DOI Listing
December 2018
5 Reads

[Quality of life as a target criterion in schizophrenia therapy].

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Praxis Dr. Wietfeld, Fachärztin für Neurologie, Psychiatrie und Psychotherapie.

Consideration of quality of life has developed into an important concept of a patient-oriented medicine in the last 50 years. With it, it should be possible to capture the subjective experience of the patients and describe its different dimensions. Today, the quality of life as a patient-reported endpoint is also an integral part of the early benefit assessment under the German Drug Market Reorganization Act. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0646-3951
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http://dx.doi.org/10.1055/a-0646-3951DOI Listing
December 2018
9 Reads

[A short essay on the spirituality of placebo from an (evolutionary) psychiatric perspective].

Authors:
Udo Bonnet

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Klinik für Psychiatrie, Psychotherapie und Psychosomatik im Evangelischen Krankenhaus Castrop-Rauxel, Castrop-Rauxel, Akademisches Lehrkrankenhaus der Universität Duisburg-Essen.

Different to spirituality, the placebo-effect is well operationalized. Against this background, an attempt is made to look at a possible phenomenological relationship between the therapeutic effectiveness of spirituality and placebo. Similar context influences as well as the possible common use of a phylogenetically well conserved protective route via the mesolimbic dopaminergic reward system are highlighted. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0637-1940
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http://dx.doi.org/10.1055/a-0637-1940DOI Listing
December 2018
11 Reads

[Natural history after discharge from a hospital psychosomatic treatment - Results of a one-year follow-up].

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Zentrum für Psychiatrie Südwürttemberg, Abteilung Psychosomatische Medizin Ravensburg.

Background: The effectiveness of the inpatient psychosomatic treatment has been documented in various settings. The question of the sustainability of the improvement achieved as well as the prognostic factors is of interest for public health.

Objective: Primary outcome variables reflect the stability or change in the clinical status of patients one year after the discharge from the inpatient psychosomatic treatment. Read More

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http://dx.doi.org/10.1055/a-0621-8864DOI Listing
December 2018
5 Reads

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0653-7349
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http://dx.doi.org/10.1055/a-0653-7349DOI Listing
December 2018
5 Reads

[Coercion and aggression in psychiatry: the individual psychological dimension of aggressive and coercive acts by therapists].

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-Universitätsklinikum der Ruhr-Universität Bochum.

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http://dx.doi.org/10.1055/a-0597-1974DOI Listing
December 2018
2 Reads

Psychiatric comorbidy in Ullrich-Turner syndrome.

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Ruhr-Universität Bochum, Psychiatrie.

Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.

Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0621-9108
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http://dx.doi.org/10.1055/a-0621-9108DOI Listing
December 2018
8 Reads

[Botulinumtoxin for bladder disorders].

Fortschr Neurol Psychiatr 2018 Dec 3. Epub 2018 Dec 3.

Marien Hospital Herne, Universitätsklinikum der Ruhr- Universität Bochum, Abteilung für Neuro-Urologie.

An overactive neurogenic detrusor and an non-neurogenic overactive bladder both exhibit symptoms such as urgency and frequency, both with and without urinary incontinence, and are often accompanied by nocturia. OnabotulinumtoxinA-Detrusorinjection has become well established as a second line therapy in cases where anticholinergic medication has failed. The procedure can be performed under general or local anesthesia, in both in- and outpatient settings. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0599-0697
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http://dx.doi.org/10.1055/a-0599-0697DOI Listing
December 2018
9 Reads

[The relationship between intake of lithium and neuroradiological alterations in bipolar disorder. Are there predictors of clinical remission?]

Fortschr Neurol Psychiatr 2018 Nov 19. Epub 2018 Nov 19.

Medizinische Univerisität Graz, Universitätsklinik für Psychiatrie und psychotherapeutische Medizin.

For avoiding affective episodes, patients with bipolar disorders are treated with mood stabilizers. Under that term, the substances lithium, valproic acid, lamotrigine and carbamazepine are included. In the light of upcoming new psychiatric concepts, the use of second generation antipsychotics is also taken into consideration in pharmacological treatment. Read More

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http://dx.doi.org/10.1055/a-0637-1820DOI Listing
November 2018
3 Reads

[Risk factors for hypertensive and cerebral amyloid angiopathy associated intracerebral hemorrhage: a retrospective comparison].

Fortschr Neurol Psychiatr 2018 Dec 12;86(12):763-769. Epub 2018 Nov 12.

Klinik für Neurologie, HELIOS Kliniken Schwerin, Schwerin, Deutschland.

Introduction: The aim of this study was to compare possible risk factors for the most common forms of spontaneous intracerebral hemorrhage (ICH), namely hypertensive and cerebral amyloid angiopathy (CAA) associated ICH.

Methods: Retrospectively, different parameters and factors were compared in patients with hypertensive ICH (n = 141) and patients with a CAAassociated ICH (n = 95). These included age, INR value and blood pressure at admission, cardiovascular risk factors as well as pre-medication. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0732-5523
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http://dx.doi.org/10.1055/a-0732-5523DOI Listing
December 2018
11 Reads

Traumatisierung und Depression.

Fortschr Neurol Psychiatr 2018 10 25;86(10):654-666. Epub 2018 Oct 25.

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http://dx.doi.org/10.1055/a-0648-0219DOI Listing
October 2018
1 Read

[Guideline "Legal evaluation after closed brain injury in adulthood"].

Fortschr Neurol Psychiatr 2018 10 25;86(10):635-653. Epub 2018 Oct 25.

In 2005 and 2013, the "Deutsche Gesellschaft für Neurowissenschaftliche Begutachtung" (German Society for Neuroscientific Evaluation) together with other societies developed and consented guidelines fort the legal evaluation of patients with closed head injuries and published them trough the National Working Group of Scientific Medical Societies and in this journal. Five years later, a revision was necessary, this was developed on the higher S2 k level of consent through a Delphi conference. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0677-7068
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http://dx.doi.org/10.1055/a-0677-7068DOI Listing
October 2018
3 Reads

[What is new in the new guideline on legal evaluation after closed head injury?]

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Fortschr Neurol Psychiatr 2018 10 25;86(10):615. Epub 2018 Oct 25.

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http://dx.doi.org/10.1055/a-0721-2885DOI Listing
October 2018
1 Read

[Anti-IgLON5 syndrome - what is our current understanding?]

Fortschr Neurol Psychiatr 2018 09 26;86(9):559-565. Epub 2018 Sep 26.

Friedrich-Baur-Institut, Klinikum der Universität München.

In 2014, antibodies against the cell surface protein IgLON5 were first described in patients with a complex neurological syndrome of sleep disturbances and movement disorders. Since then, the clinical spectrum has steadily expanded and now includes brainstem syndromes, autonomic and neuropsychiatric disorders and, more rarely, peripheral symptoms such as fasciculations and neuromyotonia. Anti-IgLON5 antibodies are thought to cause neurodegeneration in specific CNS regions with tau deposits ("tauopathy"). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0665-4593
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http://dx.doi.org/10.1055/a-0665-4593DOI Listing
September 2018
2 Reads

ERRATUM.

Authors:

Fortschr Neurol Psychiatr 2018 09 26;86(9):E1. Epub 2018 Sep 26.

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http://dx.doi.org/10.1055/a-0748-8465DOI Listing
September 2018
1 Read

Nebenwirkungen der neuen Antidepressiva.

Fortschr Neurol Psychiatr 2018 09 24;86(9):592-603. Epub 2018 Sep 24.

One reason for the increasing use of new antidepressant drugs is due to a decreased toxicity compared to older agents. Nevertheless, there are still potentially dangerous side effects important to be considered. To improve treatment outcome it is therefore advantageous to obtain a detailed medical history, as well as to give specific information about the mechanisms of action of antidepressants before choosing the appropriate drug. Read More

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http://dx.doi.org/10.1055/a-0648-1760DOI Listing
September 2018
4 Reads

[Diagnostic and Therapeutic Approaches for Mitochondrial Diseases].

Fortschr Neurol Psychiatr 2018 09 24;86(9):584-591. Epub 2018 Sep 24.

Ludwig-Maximilians-Universität München, Friedrich- Baur-Institut der Neurologischen Klinik.

Mitochondrial diseases (MD) represent a heterogenous group of disorders and syndromes caused either by mutations of the mitochondrial DNA (mtDNA) or the nuclear DNA (nDNA). They belong to the most frequent neurogenetic diseases. The spectrum of clinical manifestations is very broad ranging from mild subclinical presentations to rapidly progressive debilitating conditions with reduced life expectancy. Read More

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http://dx.doi.org/10.1055/a-0621-9255DOI Listing
September 2018
7 Reads

[Dystrophic and non-dystrophic myotonias].

Fortschr Neurol Psychiatr 2018 09 24;86(9):575-583. Epub 2018 Sep 24.

Friedrich-Baur-Institut, Neurologische Klinik, Ludwig Maximilian Universität München.

Myotonic syndromes are rare neuromuscular diseases characterized by the clinical or neurophysiological detection of myotonia. The genetic defects involve primarily or secondarily the muscular isoforms of the ion channels. The channel dysfunction consecutively leads to a hyper-excitability of the muscle membrane and the clinical symptom myotonia. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0635-8285
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http://dx.doi.org/10.1055/a-0635-8285DOI Listing
September 2018
21 Reads

[Immune-mediated / inflammatory and hereditary neuropathies - overview and diagnostic algorithm].

Fortschr Neurol Psychiatr 2018 09 24;86(9):566-574. Epub 2018 Sep 24.

Friedrich-Baur-Institut, Neurologische Klinik und Poliklinik, Klinikum der LMU München.

This paper is a practical survey of immune-mediated, inflammatory and hereditary neuropathies along with recommendations for diagnostic procedures. The large group of immune-mediated, inflammatory neuropathies includes the Guillain-Barré syndrome and chronic-inflammatory demyelinating polyradiculoneuropathy and their subtypes, vasculitic, paraneoplastic and paraproteinemic neuropathies as well as neuropathies resulting from connective tissue disorders. Besides clinical features such as time-dependent progression and distribution of sensorimotor deficits, characteristic electroneurographic findings and antibody profiles are considered. Read More

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http://dx.doi.org/10.1055/a-0655-7659DOI Listing
September 2018
3 Reads

[Myasthenia gravis: current status of antibody diagnostics and aspects on refractory myasthenia gravis].

Fortschr Neurol Psychiatr 2018 09 24;86(9):551-558. Epub 2018 Sep 24.

Friedrich-Baur-Institut, Klinikum der Universität München.

Acquired myasthenia gravis (MG) is an autoimmune disease that leads to fluctuating muscle weakness and fatigue, caused by circulating antibodies against different structures of the neuromuscular junction. In most patients, antibodies against acetylcholine receptor (AChR) can be detected. In a smaller proportion of patients with and without AChR antibodies, antibodies to muscle-specific kinase (MuSK), or related proteins such as agrin, cortactin and low-density lipoprotein receptor-related protein 4 (LRP4), are present. Read More

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http://dx.doi.org/10.1055/a-0624-9397DOI Listing
September 2018
9 Reads

[Spinal muscular atrophy - clinical spectrum and therapy].

Fortschr Neurol Psychiatr 2018 09 24;86(9):543-550. Epub 2018 Sep 24.

Friedrich-Baur-Institut, Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.

Spinal muscular atrophy (SMA) is a progressive autosomal recessive motor neuron disease with an incidence of 1:10,000 live births, caused by loss of the survival motor neuron 1 gene (SMN1), and represents the most frequent neurodegenerative disorder in children. With greater understanding of the molecular basis of SMA in the past two decades, a major focus of therapeutic developments has been on increasing the fulllength SMN protein by increasing the inclusion of exon 7 in SMN2 transcripts, enhancing SMN2 gene expression, stabilizing the SMN protein or replacing the SMN1 gene. Although the SMA research field is rapidly expanding with new therapeutic opportunities, there are still several issues that remain unsolved. Read More

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http://dx.doi.org/10.1055/a-0621-9139DOI Listing
September 2018
7 Reads

[Molecular therapies in muscular dystrophies].

Fortschr Neurol Psychiatr 2018 09 24;86(9):535-542. Epub 2018 Sep 24.

Friedrich-Baur-Institut, Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.

Muscular dystrophies (MD) are a clinically and genetically heterogeneous group of skeletal muscle-wasting diseases with progressive muscle weakness and atrophy, while disease severity depends on the subtype of the disease. Tremendous progress in basic research and an improved understanding of the pathophyisology of the disease have led to various molecular pipeline therapies for MD. Within the last years, promising new molecular therapies have been developed facilitating causative therapy in the near future. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0624-9513
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http://dx.doi.org/10.1055/a-0624-9513DOI Listing
September 2018
3 Reads

[Update diagnostic algorithm for myopathies].

Authors:

Fortschr Neurol Psychiatr 2018 09 24;86(9):532-534. Epub 2018 Sep 24.

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http://dx.doi.org/10.1055/a-0621-9201DOI Listing
September 2018
2 Reads

[Dementia with Lewy bodies].

Fortschr Neurol Psychiatr 2018 09 21;86(S 01):S43-S47. Epub 2018 Sep 21.

Klinik für Neurologie, Klinikum rechts der Isar, Technische Universität München und Lehrstuhl für Translationale Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) München.

Dementia with Lewy bodies is characterized histopathologically by the deposition of α-synuclein in inclusion bodies. Clinical diagnosis is based on progressive cognitive deficits, cognitive fluctuations, early visual hallucinations, REM sleep disorders and symptoms of Parkinsonism. On the basis of the new criteria published in 2017, better differentiation from other neurodegenerative diseases with dementia should be possible. Read More

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http://dx.doi.org/10.1055/a-0696-6249DOI Listing
September 2018
5 Reads

[Nutritional aspects in Parkinson's disease: disease risk, dietary therapy and treatment of digestive tract dysfunction].

Fortschr Neurol Psychiatr 2018 09 21;86(S 01):S34-S42. Epub 2018 Sep 21.

Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn und Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE e. V., Bonn).

Epidemiological studies suggest an association of certain foods with the risk of Parkinson's disease. Also, a number of studies revaeled positive effects on disease progression by caffeine, higher uric acid and total cholesterol levels - especially in men. However, it is not yet clear whether a specific dietary concept or the effects of the intestinal microbiota on the human metabolism could play a role in the course of the disease. Read More

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http://dx.doi.org/10.1055/a-0681-6700DOI Listing
September 2018
4 Reads

[Neuropalliative care aspects in patients with Parkinson's disease].

Fortschr Neurol Psychiatr 2018 09 21;86(S 01):S30-S33. Epub 2018 Sep 21.

Institut für Pflegewissenschaften der PMU Salzburg.

Palliative Care in Parkinson's Disease (PD) is of growing interest. The burden of symptoms of late-stage PD patients is similar or even higher than those of patients suffering from oncological diseases. However, patients suffering from advanced phases of PD have tremendous unmet palliative care needs. Read More

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http://dx.doi.org/10.1055/a-0671-2115DOI Listing
September 2018
1 Read

[18th Experts Meeting Parkinson in Frankfurt / Main].

Authors:

Fortschr Neurol Psychiatr 2018 09 21;86(S 01):S4. Epub 2018 Sep 21.

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http://dx.doi.org/10.1055/a-0646-1096DOI Listing
September 2018
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[Effectiveness and safety of safinamide as add-on to levodopa in patients with parkinson's disease: non-interventional study].

Fortschr Neurol Psychiatr 2018 10 24;86(10):624-634. Epub 2018 Aug 24.

Medizinische Abteilung, Zambon GmbH, Berlin.

Aim: Safinamide (Xadago) is a newly approved selective MAO-B inhibitor for the treatment of Parkinson's Disease (PD). The X-TRA study investigated the efficacy and tolerability of the substance under clinical practice conditions.

Methods: Prospective, observational study in unselected patients in line with safinamide product specifications. Read More

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http://dx.doi.org/10.1055/a-0665-4667DOI Listing
October 2018
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Small-Fiber-Neuropathien.

Fortschr Neurol Psychiatr 2018 08 20;86(8):509-518. Epub 2018 Aug 20.

Small fiber neuropathies (SFN) comprise a clinical syndrome typically associated with acral burning pain, where the pathophysiological processes affect the thinly myelinated A-delta and the unmyelinated C nerve fibers. Neurological examination thus reveals merely thermal sensory deficits. Nerve conduction studies in SFN are normal to marginally abnormal. Read More

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http://dx.doi.org/10.1055/a-0648-0450DOI Listing
August 2018
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[Contributions to reduce coercion in psychiatric care].

Fortschr Neurol Psychiatr 2018 08 20;86(8):500-508. Epub 2018 Aug 20.

Reduction in coercion in psychiatric treatment requires successful interaction between changes in structural preconditions and therapeutic processes, as well as in individual therapeutic skills and attitudes. The article gives an overview of current approaches and possibilities to minimize the use of coercive interventions and to create non-violent and participative therapeutic settings. These opportunities are discussed against the background of structural and staff resources, social and legal aspects, as well as subjective experience of patients and their right to protection and treatment in phases when freedom of will and self- determination are compromised. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0604-2714
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http://dx.doi.org/10.1055/a-0604-2714DOI Listing
August 2018
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[How human rights can guide german psychiatry].

Authors:
Volkmar Aderhold

Fortschr Neurol Psychiatr 2018 08 20;86(8):477-484. Epub 2018 Aug 20.

Universitätsmedizin Greifswald, Institut für Sozialpsychiatrie Mecklenburg-Vorpommern e. V. .

The concerns and recommendations of the UN "Final Remarks" on the first German State Report are substantiated by up-to-date health reporting data. Their "recommendations" are substantiated by evidence-based care models and supplemented by additional content from the Special Rapporteur's report of 2017 as visions for German psychiatric care, thus demonstrating the path of psychiatry determined by respect for human rights and social inclusion. The avoidance of coercion through traumainformed treatment and the development of complex outpatient treatment structures through the models of open dialogue and the recovery approach are seen as the focus of a paradigm shift. Read More

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http://dx.doi.org/10.1055/a-0646-4054DOI Listing
August 2018
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Einhaltung der Menschenrechte in der Psychiatrie.

Fortschr Neurol Psychiatr 2018 08 20;86(8):493-499. Epub 2018 Aug 20.

Prosecutors Office Zweibrücken (senior prosecutor, retired).

The article provides an overview of the origins and practical work on national and international control mechanisms, initiated by the United Nations, for the observance of human rights in psychiatry in Germany and worldwide. Historical, legal and psychiatric developments will be presented ranging from Pinel 200 years ago to the Universal Declaration of Human Rights in 1948 and the United Nations Convention against Torture (CAT). The National Agency for the Prevention of Torture and Ill-treatment in Germany will be presented, which has visited about forty psychiatric institutions since its establishment and has reported its observations to the public. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0653-7318
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http://dx.doi.org/10.1055/a-0653-7318DOI Listing
August 2018
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[The influence of the UN Convention on the Rights of Persons with Disabilities on the German jurisdiction and legalisation regarding compulsory measures].

Authors:
Sabine Müller

Fortschr Neurol Psychiatr 2018 08 20;86(8):485-492. Epub 2018 Aug 20.

Charité - Universitätsmedizin Berlin, Klinik für Psychiatrie und Psychotherapie CCM.

The UN Convention for the Rights of People with Disabilities (CRPD) has influenced the jurisdiction and legislation on psychiatry in Germany. It played a role in several landmark decisions of the Federal Constitutional Court and of the Federal Supreme Court, which again initiated changes of the guardianship law and of different federal mental health laws. Furthermore, the CRPD has triggered an intensive discussion within psychiatry, which has led to a more critical and cautious use of coercive measures. Read More

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http://dx.doi.org/10.1055/a-0597-2031DOI Listing
August 2018
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[Effects and side effects of the disease concept "Homosexuality"].

Fortschr Neurol Psychiatr 2018 08 20;86(8):469-476. Epub 2018 Aug 20.

Universitätsinstitut für Klinische Psychologie, > Christian -Doppler - Klinik, > Paracelsus Medizinische Privatuniversität, Bereich für Krisenintervention und Suizidprävention.

The diagnosis of homosexuality was removed from the DSM in 1973 and from the ICD in 1991. Despite this formal depathologization, negative effects of the concept of "homosexuality" as a disease, which stems from the 19th century, are still evident to this day and will be highlighted in this article. Furthermore, we also demonstrate the related interactions between social and medical processes. Read More

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http://dx.doi.org/10.1055/a-0653-7177DOI Listing
August 2018
2 Reads