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Peptides 2021 Jun 18:170598. Epub 2021 Jun 18.

Laboratory of Food Quality Design and Development, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, 611-0011, Japan. Electronic address:

Soybean is one of most important source of plant protein and is known for its wide range of agricultural, food, and industrial applications as well as health benefits. Interest in soybean proteins has been steadily growing as progressively more applications and benefits are discovered. This review article is focused on the major seed storage proteins of soybean, their three-dimensional structures, their nutritional importance and bioactive peptides, cellular synthesis, and accumulation in seeds. Read More

J Vis Exp 2021 Jun 2(172). Epub 2021 Jun 2.

AbbVie, Cambridge Research Center;

The immune system functions to defend humans against foreign invaders such as bacteria and viruses. However, disorders of the immune system may lead to autoimmunity, inflammatory disease, and cancer. The inflammatory bowel diseases (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-are chronic diseases marked by relapsing intestinal inflammation. Read More

Alzheimers Dement 2021 Jun 20. Epub 2021 Jun 20.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, 72 East Concord Street, Boston, Massachusetts, 02118, USA.

Introduction: Findings regarding the association between mitochondrial DNA (mtDNA) variants and Alzheimer's disease (AD) are inconsistent.

Methods: We developed a pipeline for accurate assembly and variant calling in mitochondrial genomes embedded within whole exome sequences (WES) from 10,831 participants from the Alzheimer's Disease Sequencing Project (ADSP). Association of AD risk was evaluated with each mtDNA variant and variants located in 1158 nuclear genes related to mitochondrial function using the SCORE test. Read More

Cancer Biomark 2021 Jun 12. Epub 2021 Jun 12.

Department of Urology Surgery, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.

This paper aimed at investigating AS1 expression in prostate cancer (PCa) and its effects on the proliferation and invasion of prostate cancer cells (PCCs). The prostate tissues and the matched adjacent normal prostate tissues excised and preserved during radical prostatectomy in our hospital were collected. The LncRNA NCK1-AS1 expression was detected. Read More

Access Microbiol 2021 Feb 7;3(2):000193. Epub 2021 Jan 7.

Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection & Immunity, Melbourne, Victoria, Australia.

In the last 10 years, the barriers preventing the uptake of foreign DNA by clinical isolates have been identified and powerful mutagenesis techniques such as allelic exchange are now possible in most genotypes. However, these targeted approaches can still be cumbersome, and the construction of unmarked deletions/point mutations may take many weeks or months. Here, we introduce a streamlined allelic exchange protocol using IMxxB and the plasmid pIMAY-Z. Read More

Bull Emerg Trauma 2021 Apr;9(2):101-104

Diseases of the Abdominal Wall and Digestive System Research Group of the Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Meckel's diverticulum is the most common gastrointestinal congenital defect, which, although asymptomatic in adults, may present symptoms in obstruction, inflammation, bleeding and foreign body perforation. There are only 8 reported cases of Meckel's diverticulum perforation by chicken bone. We report a case of a 24-year-old man presenting a 2-day-history of periumbilical pain that shifted to the right lower quadrant in 24 hours. Read More

Front Oncol 2021 3;11:656851. Epub 2021 Jun 3.

CEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, Portugal.

Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. Read More

Int J Ophthalmol 2021 18;14(6):896-902. Epub 2021 Jun 18.

Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Aim: To systematically understand the genetic association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and primary open angle glaucoma (POAG).

Methods: A comprehensive literature search in Google Scholar, PubMed, Science Citation Index, Foreign Medical Literature Retrieval Service, Chinese National Knowledge Infrastructure and Wanfang Databases was performed to collect all eligible studies up to August 2019. Study selection, data abstraction and study quality evaluation were performed by two independent investigators. Read More

Cureus 2021 May 13;13(5):e15003. Epub 2021 May 13.

General Surgery , Surgical Oncology, Mohammed VI University Hospital Centre, Oujda, MAR.

Fishbone ingestion is quite common. Most of the time, patients are asymptomatic and the fish bone exits the gastrointestinal tract spontaneously. However, in some rare cases, it can drop in the appendix and induce appendicitis or even appendicitis with perforation. Read More

J Environ Health Sci Eng 2021 Jun 7;19(1):165-171. Epub 2021 Jan 7.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Melamine is widely being reported as a food adulterant. Although its toxicity is currently recognized, melamine adulterations of dairy products are ongoing to apparently increase the amount of protein. The study was conducted to investigate the determination of melamine amounts in chocolates containing powdered milk. Read More

Front Immunol 2021 3;12:689519. Epub 2021 Jun 3.

Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.

Two-dimensional (2D) materials have emerged as an important class of nanomaterials for technological innovation due to their remarkable physicochemical properties, including sheet-like morphology and minimal thickness, high surface area, tuneable chemical composition, and surface functionalization. These materials are being proposed for new applications in energy, health, and the environment; these are all strategic society sectors toward sustainable development. Specifically, 2D materials for nano-imaging have shown exciting opportunities in and models, providing novel molecular imaging techniques such as computed tomography, magnetic resonance imaging, fluorescence and luminescence optical imaging and others. Read More

Front Psychol 2021 2;12:665988. Epub 2021 Jun 2.

School of Foreign Languages, Northeast Normal University, Changchun, China.

This paper reports a cross-sectional study that investigates the developmental features in second language writings by Chinese beginner learners of English by using four lexical richness measures-lexical sophistication, lexical variation, lexical density, and lexical errors-from the perspective of the language exposure hypothesis. Specifically, the study compares English compositions written by Chinese students of grade 7, grade 8, and grade 9 in terms of lexical sophistication, lexical variation, lexical density, and lexical errors. The English compositions were sampled from the Writing Corpus of Chinese Beginner Learners of English, and the sample size of the three grades remained almost the same. Read More

Front Aging Neurosci 2021 3;13:666851. Epub 2021 Jun 3.

Aging Research Center, Karolinska Institute (KI), Stockholm University, Stockholm, Sweden.

It has previously been demonstrated that short-term foreign language learning can lead to structural brain changes in younger adults. Experience-dependent brain plasticity is known to be possible also in older age, but the specific effect of foreign language learning on brain structure in language-and memory-relevant regions in the old brain remains unknown. In the present study, 160 older Swedish adults (65-75 years) were randomized to complete either an entry-level Italian course or a relaxation course, both with a total duration of 11 weeks. Read More

Asia Eur J 2021 Jun 14:1-25. Epub 2021 Jun 14.

Social Science Research Institute, Tokai University, Tokyo, Japan.

This paper explores the impact of infrastructure on trade connectivity among ASEAN and three Asian countries-India, China, and Japan. Our study is mainly motivated by the increased infrastructure investment and trade among these countries in recent years. The main results of trade network analysis include high trade density and interconnectedness among ASEAN, India, China, and Japan. Read More

Appl Linguist 2021 Jun 10;42(3):514-540. Epub 2020 Oct 10.

Northwestern University, Evanston, IL, 60208, USA.

According to the US Department of State, a native English speaker can learn Spanish in about 600 h, but would take four times as long to learn Japanese. While it may be intuitive that similarity between a foreign language and a native tongue can influence the ease of acquisition, what is less obvious are the specific cognitive and emotional processes that can lead to different outcomes. Here, we explored the influence of cognitive strategies and affective states on native English speakers' ability to learn artificial foreign words that vary in their similarity to the native language. Read More

Nat Hazards (Dordr) 2021 Jun 16:1-25. Epub 2021 Jun 16.

Florida Institute for Built Environment Resilience, University of Florida, Gainesville, FL USA.

Research concerning the behavior of international linguistic minorities at institutions of higher education during disasters is very limited. Many international groups suffer from discrimination based on language (linguicism) during disasters-their stories are not being told, and their voices are not being heard. The main objective of our study is to develop new knowledge about disaster-related behaviors of international linguistic minorities at institutions of higher education with a view toward enhancing overall campus emergency planning. Read More

J Emerg Med 2021 Jun 17. Epub 2021 Jun 17.

Department of Pediatrics, Soroka University Medical Center, Beer Sheva, Israel; Pediatric Pulmonary Unit, Soroka University Medical Center, Beer Sheva, Israel; Faculty of Health Sciences, Ben-Gurion, University of the Negev, Beer Sheva, Israel.

Background: Spontaneous pneumomediastinum (SPM) occurs in cases of mediastinal leaks that are not caused by trauma, mechanical ventilation, or other surgical procedures. In most cases, in the pediatric population a trigger can be identified, most commonly asthma. SPM caused by foreign body aspiration is not a common entity. Read More

Rev Epidemiol Sante Publique 2021 Jun 17. Epub 2021 Jun 17.

Institut de recherche pour le développement/Development research institute, Unité mixte de recherche 216/Mixed research unit 216: Mères et enfants face aux infections tropicale/Mother and child face to tropical infection, Faculté de pharmacie Paris-Descartes, 4, avenue de l'observatoire, 75006 Paris, France. Electronic address:

Introduction: Spatial sampling is increasingly used in health surveys as it provides a simple way to randomly select target populations on sites where reliable and complete data on the general population are not available. However, the previously implemented protocols have been poorly detailed, making replication difficult or even impossible. To our knowledge, ours is the first document describing step-by-step an efficient spatial sampling method for health surveys. Read More

Gastrointest Endosc 2021 Jul;94(1):205

Department of Emergency Medicine, New Jersey Poison Information and Education System, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Curr Gene Ther 2021 Jun 18. Epub 2021 Jun 18.

Key Laboratory of The Second Affiliated Hospital of Kuming Medical College, Kunming, 650101, China.

Aims: We aim to define parameters affecting the safety and long-term transgene expression of attenuated HSV-1 vectors and optimize the expression cassettes to achieve robust and sustained expression in CNS.

Background: Engineered, attenuated Herpes simplex virus (HSV) vectors are promising vehicles for gene delivery to the peripheral and central nervous systems. The virus latent promoter (LAP) is commonly used to drive exogenous gene expression; however, parameters affecting the safety and long-term transgene expression of attenuated HSV-1 vectors have not been fully understood. Read More

Int J Dev Disabil 2017 Jul 26;65(2):65-72. Epub 2017 Jul 26.

Department of Foreign Languages and Literature, Huafan University, 1 Huafan Road, Shiding, Taipei 22301, Taiwan.

Objective: Individuals with Down syndrome have impaired linguistic ability but relatively good visuospatial cognition. A verbal-with-visual presentation enhanced the semantic grouping in individuals with Down syndrome, whereas a verbal presentation did not have this effect. This study aims to examine the influence of visual presentation on semantic grouping in individuals with Down syndrome. Read More

Neonatology 2021 Jun 18:1-5. Epub 2021 Jun 18.

Neonatal Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.

A preterm infant with birth weight 1,550 g had an intravenous foreign body between the external iliac vein and the common iliac vein, which accidentally happened during peripheral intravascular central catheter insertion by the Seldinger technique. The infant initially received conservative management and close monitoring. Antibiotics were administered 4 weeks to treat culture positive sepsis and meningitis. Read More

Orv Hetil 2021 06 20;162(25):978-987. Epub 2021 Jun 20.

3 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Egészségügyi Nyelvi és Kommunikációs Intézet, Pécs.

Összefoglaló. Bevezetés: A 21. századra a multikulturális társadalmi közegben az interkulturális tudás, mint készség, fokozott mértékben válik kulcskompetenciává. Read More

Asian J Surg 2021 Jun 16. Epub 2021 Jun 16.

Breast Disease Center, Peking University First Hospital, Beijing, China. Electronic address:

FEBS J 2021 Jun 19. Epub 2021 Jun 19.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine Aurora, CO, USA.

Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) interactions are critical for dampening the immune response to both self and foreign antigens. The signaling of PD-L1 via its cytoplasmic domain, rather than through its interactions with PD-1 via the extracellular domain, has been termed PD-L1 reverse signaling. While this signaling is beneficial for cancer progression, little is understood about the consequences of PD-L1 reverse signaling in immune cells that express PD-L1 at steady state or in response to infection. Read More

J Relig Health 2021 Jun 19. Epub 2021 Jun 19.

College of International Studies, Southwest University, Tianshengqiao Road, Beibei, Chongqing, China.

A commonplace observation across many cultures is that humans show a strong preference for natural items on drug choice in the medical domain. Despite an emerging line of psychological research on individual differences in the naturalness-is-better bias, few studies have focused on the role of religious beliefs. According to the core idea of Taoism, people should free themselves from selfishness and desire and behave in concert with the alternating cycles of Nature. Read More

Eur Child Adolesc Psychiatry 2021 Jun 19. Epub 2021 Jun 19.

Centre for Health Equity Studies, Stockholm University/Karolinska Institutet, Stockholm, Sweden.

Parental psychiatric morbidity related to experiences of war and trauma has been associated with adverse psychological outcomes for children. The aim of this study was to investigate parental post-traumatic stress in relation to psychiatric care utilization among children of refugees with particular attention on the child's own refugee status, sex of both child and parents, and specific psychiatric diagnoses. This was a register study in a population of 16 143 adolescents from refugee families in Stockholm County born 1995-2000 and followed between 2011 and 2017 (11-18 years old). Read More

Curr Top Med Chem 2021 Jun 18. Epub 2021 Jun 18.

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; b Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs, Henan Agricultural University, Zhengzhou 450046, China.

Background: Virus-like particles (VLPs) are non-genetic multimeric nanoparticles synthesized through in vitro or in vivo self-assembly of one or more viral structural proteins. Immunogenicity and safety of VLPs make them ideal candidates for vaccine development and efficient nanocarriers for foreign antigens or adjuvants to activate the immune system.

Aims: The present study aimed to design and synthesize a chimeric VLP vaccine of the phage Qbeta (Qβ) coat protein presenting the universal epitope of the coronavirus. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):580-585

Department of Sports Medicine, Peking University Third Hospital; Institute of Sports Medicine of Peking University; Beijing Key Laboratory of Sports Injuries; Beijing 100191, China.

Objective: To make a retrospective analysis of the situation and process of treating skiers' injuries in the medical station of the Wanlong ski resort in Chongli and the nearest treatment hospital, and to provide a basis for the establishment and optimization of the treatment process between the medical station of the Winter Olympics ski resort and the nearest treatment hospital, and to gain experience for medical security of mass skiing.

Methods: The data of all ski injuries in Chongli District were collected from the medical station of the Wanlong ski resort during the 2018-2019 snow season (November 2018 to April 2019) and the nearest treatment hospital during two periods (March 2019, and November 2019 to January 2020). The differences of injury causes, injury types, injury sites, and treatment effects of the injured skiers were analyzed. Read More

J Ultrasound 2021 Jun 18. Epub 2021 Jun 18.

Radiology Service, Radiology Department, Hospital Italiano de Buenos Aires, Juan D. Perón 4190, CABA, C1181ACH, Autonomous City of Buenos Aires, Argentina.

The aim of this paper is to describe the distinctive ultrasound findings of a case of vaginal bleeding caused by the presence of a foreign body. We present the case of an infant who consulted for vaginal bleeding and foul-smelling discharge. The ultrasound revealed signs of vaginal distension due to heterogeneous-hematic contents and parietal thickening. Read More