263,849 results match your criteria Foreign Bodies Rectum


A Path(way) to Keeping Your Synapses on an Even Keel.

Neuron 2018 Dec;100(5):1013-1014

Pathology and Laboratory Medicine, Weill Cornell Medicine, New York City, NY, USA.

In this issue of Neuron, Harris et al. (2018) show that a signal transduction pathway normally exploited by the innate immune system in recognizing foreign agents plays a critical role in controlling a synapse's ability to maintain stability in the efficacy of synaptic transmission over both rapid and prolonged timescales. Read More

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December 2018
2 Reads

Structure and biomechanics of the antennal grooming mechanism in the southern green stink bug Nezara viridula.

J Insect Physiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Functional Morphology and Biomechanics, Kiel University, Germany.

Insects devote a high amount of time to self-groom to remove foreign material, especially from their sensory appendages. Using various microscopy techniques and behavioural experiments on intact and ablated insects, the present study investigates the antennal grooming of the green stinkbug Nezara viridula, which represents a serious pest of different crops in most areas of the world. The antennal grooming behaviour encompass an action of scraping involving the tibial comb complex (tibial comb + fossula) of both forelegs, generally followed by the tibial comb complex grooming of one leg using the tarsal hairy pad of the opposite leg (rubbing). Read More

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December 2018

Nordic homecare nursing from the perspective of homecare nurses-a meta-ethnography.

Br J Community Nurs 2018 Dec;23(12):597-604

Associate professor, Study director, Aarhus University, Department of Public Health, Denmark.

The pressure on homecare nursing in the Nordic countries has increased in recent years because of a reorganisation of healthcare systems that has put a focus on very early discharge from hospital as well as demographic changes. This article details an analysis of the findings of 13 published qualitative research reports about Nordic homecare nurses' experiences of their work. Using a process of meta-ethnography, the authors identify five themes within the primary research: home care as a professional practice on foreign ground; home care as a massive time constraint; home care as fair rationing; home care as relationships with relatives as fellow players or opponents; and home care as latent paternalism. Read More

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December 2018

Fluorogenic probes for disease-relevant enzymes.

Chem Soc Rev 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China.

Traditional biochemical methods for enzyme detection are mainly based on antibody-based immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in particular, the in situ activity of enzymes in live cells and in vivo. In this review, we comprehensively summarize recent progress that has been made in the development of small-molecule as well as material-based fluorogenic probes for sensitive detection of the activities of enzymes that are related to a number of human diseases. The principles utilized to design these probes as well as their applications are reviewed. Read More

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December 2018

Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: seven-years results of collaboration experience.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.

Background: Screening tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis infections performed in at-risk population show a higher number of positive tests compared to those carried out in the general population. "Test & Counselling" Ambulatory of Infectious Disease Clinic (T&C-IDC) and Sexually Transmitted Diseases Ambulatory of Dermatology Unit (STDs-DU) of Modena began collaboration in 2010 and adopted a common diagnostic serological profile since 2013.

Objectives: The main objective was to analyse the number of screening tests performed in the T&C-IDC and STDs-DU, comparing the results obtained after the adoption of the shared protocol with the previous period. Read More

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December 2018

Pleural anthracosis presenting with massive effusion: a rare entity.

Respirol Case Rep 2019 Feb 28;7(2):e00390. Epub 2018 Nov 28.

Respiratory Department Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Pleural anthracosis is rare and, in most cases, is diagnosed incidentally or at autopsy. We report a 67-year-old man with pleural anthracosis. He was initially referred for possible tuberculous pleural effusion and had recurrent admissions for symptomatic pleural effusion, which increased with each subsequent episode. Read More

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February 2019

Aural foreign body removal: there is no one-size-fits-all method.

Authors:
Tian-Tee Ng

Open Access Emerg Med 2018 8;10:177-182. Epub 2018 Nov 8.

ENT Unit, Department of Surgery, Frankston Hospital. Peninsula Health, Frankston 3199, VIC, Australia,

Background: Managing patients with aural foreign body (AFB) may pose a dilemma regarding which removal technique to use for different AFB types. The current study comprises a review of all the possible methods one could employ in removing AFB. My aim was to describe the best methods for different types of AFBs, complete with a description of the method and tool(s) required, and descriptions of the AFBs for which they are best used. Read More

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November 2018

A Lodged Barramundi Fish-Bone Stabbing the Piriform Fossa in a Child.

Pediatr Emerg Care 2018 Dec;34(12):e243-e245

Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, British Columbia, Canada.

Unintentional ingestion of a fish bone is common in children, especially among families with high consumption of seafood. Complications in children are extremely rare. We describe a 3-year-old healthy boy who had a large bone of Barramundi fish lodged in his upper esophagus causing significant distress. Read More

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December 2018

The language of lies: a preregistered direct replication of Suchotzki and Gamer (2018; Experiment 2).

Cogn Emot 2018 Dec 2:1-6. Epub 2018 Dec 2.

a Department of Clinical Psychology , University of Amsterdam , Amsterdam , Netherlands.

Is lying in a different language easier or more difficult? The Emotional Distance and the Cognitive Load hypothesis give competing answers. Suchotzki and Gamer measured the time native German speakers needed to initiate honest and deceptive answers to German and English questions. Lie-truth differences in RTs were much smaller for the foreign compared to the native language. Read More

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December 2018

Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Dec 3:e1548. Epub 2018 Dec 3.

Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India.

The eye consists of sensitive, compactly adjoined tissue structures which act as strong physical (static) and physiological (dynamic) barriers that prevent entry of foreign bodies into the eye. Together, these barriers reduce the bioavailability of topically and intraocularly administered medicaments thus demanding frequent drug administration for the treatment of chronic eye diseases. Hence, development of drug delivery systems (DDS) that can be retained in ocular tissues for longer durations can help to reduce the frequency of drug administration, whereas, delivery systems that traverse through ocular barriers may offer higher bioavailability of administered drugs to otherwise inaccessible ocular tissues. Read More

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December 2018

Foreign body granulomas following cranial neurosurgical procedures.

Acta Neurochir (Wien) 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurosurgery, Adnan Menderes University Hospital, Aydın, Turkey.

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November 2018
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Aggressive granulomatosis of the hip: a forgotten mode of aseptic failure.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Hip Surgery Unit, Italian Hospital of Buenos Aires, Institute of Orthopaedics "Carlos E. Ottolenghi", 4247 Potosí St, C1199ACK, Buenos Aires, Argentina.

Purpose: It has been acknowledged that implant wear correlates with the risk for periprosthetic osteolysis, being aggressive granulomatosis the worst expression of bone resorption. We sought to determine the clinical, radiological, and histological features of aggressive granulomatosis after primary total hip arthroplasty (THA).

Methods: We included nine cases with aggressive granulomatosis of the hip around cemented stems. Read More

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November 2018

Cholangioscopy in the digital era.

Transl Gastroenterol Hepatol 2018 29;3:82. Epub 2018 Oct 29.

Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville, FL, USA.

Cholangioscopy allows direct visualization and subsequent therapeutic maneuvers of the biliary ductal system. With advances in endoscopic and imaging technology, cholangioscopy has become an important modality for the diagnosis of indeterminate biliary strictures and an essential therapeutic tool for difficult to remove biliary stones. Enhanced imaging and operability of the latest generation cholangioscopes have further expanded their clinical applications to include ductal tumor ablation, gallbladder drainage, access to difficult to reach branches of the biliary tree, and biliary foreign body manipulation. Read More

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October 2018
2 Reads

Rigid endoscope guided removal of penetrated embedded neck foreign body.

Trauma Case Rep 2018 Dec 16;18:5-7. Epub 2018 Nov 16.

Department of Otorhinolaryngology, Hospital Tengku Ampuan Rahimah, 41200 Klang, Selangor, Malaysia.

Penetrative neck injury can cause potentially fatal damage to the neck. Removing those fully embedded small foreign bodies secondary to ballistic trauma can be technically challenging. Neck exploration under direct vision may cause more local tissue damage or dislodge the foreign body further. Read More

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December 2018
2 Reads

Shifting global health governance towards the sustainable development goals.

Bull World Health Organ 2018 Dec;96(12):798-798A

College of Medicine and Health, University of Exeter, Exeter, England.

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December 2018

Interaction and involvement of cellular adhesion molecules in the pathogenesis of Schistosomiasis mansoni.

Immunol Lett 2018 Nov 29;206:11-18. Epub 2018 Nov 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with Schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. Read More

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November 2018

Dynamics of Cas10 Govern Discrimination between Self and Non-self in Type III CRISPR-Cas Immunity.

Mol Cell 2018 Nov 27. Epub 2018 Nov 27.

Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

Adaptive immune systems must accurately distinguish between self and non-self in order to defend against invading pathogens while avoiding autoimmunity. Type III CRISPR-Cas systems employ guide RNA to recognize complementary RNA targets, which triggers the degradation of both the invader's transcripts and their template DNA. These systems can broadly eliminate foreign targets with multiple mutations but circumvent damage to the host genome. Read More

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November 2018

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Mol Cell 2018 Nov 27. Epub 2018 Nov 27.

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address:

Type ΙΙΙ CRISPR-Cas systems provide robust immunity against foreign RNA and DNA by sequence-specific RNase and target RNA-activated sequence-nonspecific DNase and RNase activities. We report on cryo-EM structures of Thermococcus onnurineus Csm binary, Csm-target RNA and Csm-target RNA ternary complexes in the 3.1 Å range. Read More

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November 2018

Langerhans cell histiocytosis of the skull in the burr-hole site covered with hydroxyapatite material: a case report.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, Ebina General Hospital, Kanagawa, Japan.

Background: We present a case report of a male patient with Langerhans cell histiocytosis (LCH), which occurred in a burr-hole site for chronic subdural hematoma covered with hydroxyapatite material. LCH is a rare dendritic histiocytic disorder that affects the bones, especially the skull. Until now, the association with foreign-body reaction has rarely been reported by any author. Read More

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November 2018
2 Reads

Are coagulase-negative staphylococci virulent?

Clin Microbiol Infect 2018 Nov 28. Epub 2018 Nov 28.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany. Electronic address:

Background: Progress in contemporary medicine is associated with an increasing number of immunocompromised individuals. In this vulnerable group, the underlying disease together with long-term hospitalization and the use of medical devices facilitate infections by opportunistic pathogens for which coagulase-negative staphylococci (CoNS) represent a prime example.

Objectives: The diversity of CoNS with species- and strain-specific differences concerning virulence and clinical impact is highlighted. Read More

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November 2018

International Board Members of the American Journal of Ophthalmology.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Medical University of Gdańsk, Poland.

This year marks the 100th anniversary of the "modern" American Journal of Ophthalmology (AJO). International influence was present since the beginnings of the journal, and AJO had several foreign editorial board members and collaborators. Within the article we present sketches of the deceased international board members of the AJO, particularly of Sir Stewart Duke-Elder, Pierre Amalric, Joaquin Barraquer and Yasuo Tano. Read More

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November 2018

A prospective Study on Femoral Hernia Repair: Is the Inguinal Better Than The Infrainguinal Approach?

J Surg Res 2019 Jan 19;233:420-425. Epub 2018 Sep 19.

Department of Gastrointestinal Surgery, Hernia Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Femoral hernia repair has various surgical methods. However, controversy still exists regarding the best method for management. This study aimed to compare the infrainguinal with the inguinal approach in the treatment of femoral hernias. Read More

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January 2019

Analysis of Related Factors for the Retention Time of Tracheobronchial Foreign Bodies in Pediatrics.

J Surg Res 2019 Jan 4;233:262-267. Epub 2018 Sep 4.

Department of Otorhinolaryngology, Children's Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: This study aims to investigate the related factors for the retention time of tracheobronchial foreign bodies in infants and children, to provide help for the assessment of the disease, surgical risk, and prognosis.

Materials And Methods: The clinical data of 1060 patients with tracheobronchial foreign bodies from January 2015 to December 2015 were retrospectively studied, and the correlation of the retention time of foreign bodies with age, gender, preoperative complications, granulation formation, operation time, and hospital stay was analyzed.

Results: The retention time of foreign bodies was not correlated with age (r = 0. Read More

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January 2019

A non-canonical phosphorylation site in β-casein A from non-Mediterranean water buffalo makes quantifiable the adulteration of Italian milk with foreign material by combined isoelectrofocusing-immunoblotting procedures.

Food Chem 2019 Mar 19;277:195-204. Epub 2018 Oct 19.

Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, Italy. Electronic address:

The need of controlling illegal addition of water buffalo (WB) milk from foreign countries to the Italian counterpart devoted to the production of Protected Denomination of Origin (PDO) Mozzarella di Bufala Campana (MBC) cheese has promoted the development of simple, fast and cheap isoelectrofocusing (IEF) methods for evaluating the nature of the raw material to be used according to a high-throughput sample multiplexing format, avoiding the use of dedicated mass spectrometry-based procedures. Thus, combined proteomic methods were here integrated with optimized western blotting protocols in solving the complex IEF pattern of casein (CN) mixtures observed when Italian and foreign WB milk are mixed together. Identification of internally deleted α-CN hepta-phosphorylated species as well as of still unknown β-CN A hexa-phosphorylated and N-terminally-nicked β-CN A phosphorylated forms present uniquely in foreign WB milk samples, allowed recognizing these molecules as adulteration markers to be assayed in combined IEF-immunoblotting procedures; the latter ones showing optimal migration characteristics to be used in routine assays. Read More

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Simulation Training for Operational Medicine Providers (STOMP): Impact of a Comprehensive Skills-Based Curriculum for Military General Medical Officers.

Mil Med 2018 Dec 4. Epub 2018 Dec 4.

Healthcare Simulation and Bioskills Training Center, Naval Medical Center, 620 John Paul Jones Circle, Portsmouth, VA.

Introduction: A standardized training curriculum designed for general medical officers (GMO) titled Simulation Training for Operational Medicine Providers (STOMP) was recently developed to educate and improve GMOs' procedural skills through directed feedback prior to assuming duties in an operational environment. This study aimed to determine the impact this novel curriculum had on GMOs'confidence levels in 21 core privileges covering eight different subspecialties while stationed at Naval Medical Center Portsmouth (NMCP).

Materials And Methods: A cohort study from 2015 to 2017 was designed to address our specific aim to examine if the implementation of the STOMP curriculum increased GMOs' confidence levels. Read More

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December 2018
1 Read

Listener characteristics modulate the semantic processing of native vs. foreign-accented speech.

PLoS One 2018 5;13(12):e0207452. Epub 2018 Dec 5.

Department of Linguistics, Macquarie University, Sydney, New South Wales, Australia.

Foreign accents have been shown to have considerable impact on how language is processed [1]. However, the impact of a foreign accent on semantic processing is not well understood. Conflicting results have been reported by previous event-related potential (ERP) studies investigating the impact of foreign-accentedness on the N400 effect elicited by semantic violations. Read More

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December 2018
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Socioeconomic status in Danish women with polycystic ovary syndrome. A register-based cohort study.

Acta Obstet Gynecol Scand 2018 Dec 5. Epub 2018 Dec 5.

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Introduction: Low socioeconomic status (SES) could be associated with increased risk of polycystic ovary syndrome (PCOS) and vice versa. Possible associations between SES, obesity, and ethnicity in PCOS are undetermined MATERIAL AND METHODS: National register-based study including women with PCOS aged 25 years or above (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. PCOS Denmark (N=13,891) included women with PCOS in the Danish National Patient Register. Read More

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December 2018

Current Data of Foreign-Educated Nurses in Italy and the Recognition of Their Professional Qualifications.

Nurs Adm Q 2019 Jan/Mar;43(1):26-31

Health Professions Research and Development Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy (Dr Caruso); Centre of Excellence for Nursing Scholarship, OPI Rome, Italy (Drs Rocco and Stievano); CGFNS International, Inc, Philadelphia, Pennsylvania (Dr Shaffer); and Nursing and Health Policy, International Council of Nurses, Geneva, Switzerland (Dr Stievano).

Up-to-date data on foreign-educated nurses (FENs) in Italy and the recognition of their professional qualifications are pivotal to boost international discussion, and to improve the engagement and involvement of multistakeholders in the nursing profession. Currently, FENs in Italy represent roughly 6% of the total number of registered nurses. FENs are predominantly females between 35 and 54 years old. Read More

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December 2018

PROBLEM-ORIENTED MEDICAL RECORD AS A CHALLENGE FOR NARRATOLOGICAL ANALYSIS.

Georgian Med News 2018 Oct(283):180-183

Ukrainian Medical Stomatological Academy, Department of Foreign Languages with Latin and Medical Terminology, Poltava; Ivano-Frankivsk National Medical University, Department of Linguistics, Ukraine.

The paper examines the narrative arrangement of the problem-oriented medical record (POMR) as an effective method of registering and assessing clinical data. The aim of the research is to examine the types of narrators and focalization, as well as the hierarchy and interaction of narrative levels in the analyzed discourse. The research has demonstrated the presence of several types of narrators within the analyzed discourse: (1) the omniscient hetero-extradiegetic narrator with transient internal focalization (the third-person narration, represented by the physician) and (2) homo-intradiegetic narration (patient's first-person narration) in the "Subjective Observation" section; (3) the "estranged" heterodiegetic narrator with external focalization (the "Objective Observation" part); (4) the "uncertain" type of narrator (the "Assessment" part); (5) and the imperative mode of narration (the "Plan" section). Read More

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October 2018

Adenosine 2a receptor signals block autoimmune arthritis by inhibiting pathogenic germinal center T follicular helper cells.

Arthritis Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatic and Autoimmune Diseases, Department of Medicine and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.

Objective: CD4 germinal center (GC)-T follicular helper (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor (A2aR, Adora2a) signaling can divert CD4 T cells away from the GC-Tfh cell lineage during the primary response to foreign antigens. Therefore, we examined the effects of A2aR signaling on CD4 T cells during the recognition of a self-antigen using a mouse model of autoimmune arthritis. Read More

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December 2018

The effect of poly-p-dioxanone plates on the protection and vitality of cartilage: An animal study.

Laryngoscope 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkey.

Objectives/hypothesis: In septorhinoplasty, septal, auricular, and costal cartilage are often used as autologous graft. Autologous grafts are preferred in nasal reconstruction. The aim of this study was to histopathologically examine the tissue compatibility and the effect on the stability and cartilage vitality of poly-p-dioxanone (PDS) plates. Read More

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December 2018

From the maxillary sinus to the stomach: a rare case report of a displaced fragment of dental implant.

Eur J Oral Implantol 2018 ;11(4):469-473

Purpose: To present a rare clinical case of migration of a displaced implant fragment from the maxillary sinus to the stomach.

Materials And Methods: A 66-year-old man was referred from a local dental clinic to remove a displaced implant apical fragment in the left maxillary sinus. After 15 days from the displacement, no foreign body was seen in the maxillary sinus or in any other craniofacial cavity. Read More

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January 2018

A framework for the development of effective anti-metastatic agents.

Nat Rev Clin Oncol 2018 Dec 4. Epub 2018 Dec 4.

Commercial Partnerships, Cancer Research UK (CRUK), London, UK.

Most cancer-related deaths are a result of metastasis, and thus the importance of this process as a target of therapy cannot be understated. By asking 'how can we effectively treat cancer?', we do not capture the complexity of a disease encompassing >200 different cancer types - many consisting of multiple subtypes - with considerable intratumoural heterogeneity, which can result in variable responses to a specific therapy. Moreover, we have much less information on the pathophysiological characteristics of metastases than is available for the primary tumour. Read More

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December 2018

DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins.

Nat Commun 2018 Dec 4;9(1):5165. Epub 2018 Dec 4.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.

Recognition and repression of RNA targets by Argonaute proteins guided by small RNAs is the essence of RNA interference in eukaryotes. Argonaute proteins with diverse structures are also found in many bacterial and archaeal genomes. Recent studies revealed that, similarly to their eukaryotic counterparts, prokaryotic Argonautes (pAgos) may function in cell defense against foreign genetic elements but, in contrast, preferably act on DNA targets. Read More

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December 2018

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Proc Natl Acad Sci U S A 2018 Dec 4. Epub 2018 Dec 4.

Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, 300071 Tianjin, China.

Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. SVV mediates cell entry by attachment to the receptor anthrax toxin receptor 1 (ANTXR1). Here we determine atomic structures of mature SVV particles alone and in complex with ANTXR1 in both neutral and acidic conditions, as well as empty "spent" particles in complex with ANTXR1 in acidic conditions by cryoelectron microscopy. Read More

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December 2018
4 Reads

Avoidance of Trinucleotide Corresponding to Consensus Protospacer Adjacent Motif Controls the Efficiency of Prespacer Selection during Primed Adaptation.

MBio 2018 Dec 4;9(6). Epub 2018 Dec 4.

Center for Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.

CRISPR DNA arrays of unique spacers separated by identical repeats ensure prokaryotic immunity through specific targeting of foreign nucleic acids complementary to spacers. New spacers are acquired into a CRISPR array in a process of CRISPR adaptation. Selection of foreign DNA fragments to be integrated into CRISPR arrays relies on PAM (protospacer adjacent motif) recognition, as only those spacers will be functional against invaders. Read More

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December 2018

Design Methodology of Microservices to Support Predictive Analytics for IoT Applications.

Sensors (Basel) 2018 Dec 2;18(12). Epub 2018 Dec 2.

Department of Information and Communications Engineering, Hankuk University of Foreign Studies, Seoul 02450, Korea.

In the era of digital transformation, the Internet of Things (IoT) is emerging with improved data collection methods, advanced data processing mechanisms, enhanced analytic techniques, and modern service platforms. However, one of the major challenges is to provide an integrated design that can provide analytic capability for heterogeneous types of data and support the IoT applications with modular and robust services in an environment where the requirements keep changing. An enhanced analytic functionality not only provides insights from IoT data, but also fosters productivity of processes. Read More

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December 2018

Systemic Dissemination of Injected Foreign Material.

J Forensic Sci 2018 Dec 4. Epub 2018 Dec 4.

Forensic Science SA, GPO Box 2790, Adelaide, 5001.

A 32-year-old woman collapsed following an intravenous injection of material that included crushed pharmaceutical tablets. Resuscitation was attempted but was unsuccessful. She had an extensive past medical history of complications resulting from intravenous drug use. Read More

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December 2018
3 Reads

Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction.

Mol Ther Nucleic Acids 2018 Dec 30;13:699-709. Epub 2018 Oct 30.

Translational Medicine, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Paediatrics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; thus, its expression may prompt the immune system to eliminate gene-edited cells. Read More

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December 2018
3 Reads

Children judge others based on their food choices.

J Exp Child Psychol 2018 Dec 1;179:143-161. Epub 2018 Dec 1.

Department of Psychology, Cornell University, Ithaca, NY 14850, USA.

Individuals and cultures share some commonalities in food preferences, yet cuisines also differ widely across social groups. Eating is a highly social phenomenon; however, little is known about the judgments children make about other people's food choices. Do children view conventional food choices as normative and consequently negatively evaluate people who make unconventional food choices? In five experiments, 5-year-old children were shown people who ate conventional and unconventional foods, including typical food items paired in unconventional ways. Read More

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December 2018
1 Read

Toxicokinetics and Biliary Excretion of N-Nitrosodiethylamine in Rat Supplemented with Low and High Dietary Proteins.

J Diet Suppl 2018 Dec 4:1-15. Epub 2018 Dec 4.

b Nutritional Biochemistry Research Laboratory, Department of Biochemistry, College of Medicine , University of Ibadan , Ibadan , Nigeria.

Although biliary excretion is one of the biological elimination processes for foreign compounds, intake of high-protein diets was hypothesized to enhance their detoxification rates. Hence, this study investigates the effect of differential dietary protein intake on toxicokinetics and biliary excretion in rats following exposure to N-nitrosodiethylamine (NDEA) and aflatoxin B1 (AFB1). The animals were divided into five groups. Read More

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December 2018
2 Reads

Hong Kong's role in global health: Public opinion of official development assistance.

PLoS One 2018 4;13(12):e0207687. Epub 2018 Dec 4.

Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Governments in high income countries allocate funding for Official Development Assistance (ODA), and population-based surveys tend to show support for the concept of affluent nations assisting the development of poorer regions. A public opinion survey was conducted in Hong Kong to: (1) assess public support for foreign aid for social development and Hong Kong's current Disaster Relief Fund (DRF); and (2) assess how much respondents thought should be contributed to foreign aid for social development and/or DRF. Interviewers conducted a random telephone survey of Cantonese-speaking Hong Kong citizens aged 18 or above during 2017. Read More

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December 2018
1 Read

Recurrent oedema of the uvula in a patient with chronic spontaneous urticaria successfully treated with omalizumab.

Authors:
A Pannofino

J Dermatolog Treat 2018 Dec 4:1-4. Epub 2018 Dec 4.

a Allergology and Immunology Clinic , Operative Unit of Medicine , Policoro Hospital, Matera , Italy .

Uvula oedema is a condition characterized by a sensation of a foreign body in the oropharynx and difficulty to speak; sometimes, if associated to glottis oedema, difficulty to breathe and dysphonia are also present. Urticaria is a disease characterized by itching wheals on the skin, and sometimes angioedema. Chronic urticaria is spontaneous when the aetiology is unknown. Read More

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December 2018
2 Reads

Blended Nanostructured Degradable Mesh with Endometrial Mesenchymal Stem Cells Promotes Tissue Integration and Anti-Inflammatory Response in Vivo for Pelvic Floor Application.

Biomacromolecules 2018 Dec 4. Epub 2018 Dec 4.

The current urogynaecological clinical meshes trigger unfavourable foreign body response which leads to graft failure in the long term. To overcome the present challenge we applied a tissue engineering strategy using endometrial SUSD2+ Mesenchymal stem cells (eMSCs) with high regenerative properties. This study delves deeper into foreign body response to SUSD2+ eMSC based degradable PLACL/Gelatin nanofiber meshes using a mice model targeted at understanding immunomodulation and mesh integration in the long term. Read More

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December 2018
2 Reads

Live-attenuated varicella zoster virus vaccine does not induce HIV target cell activation.

J Clin Invest 2018 Dec 4. Epub 2018 Dec 4.

Background: Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny since vaccination with Ad5-vectored HIV vaccine trials demonstrated increased HIV risk in individuals with pre-immunity to the vector which was thought to be associated with mucosal immune activation (IA). Therefore, defining the impact of VZV vaccination on IA is particularly important with the prospect of developing an HIV/VZV chimeric vaccine. Read More

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December 2018

Nanowire morphology and particle phase control by tuning the In concentration of the foreign metal nanoparticle.

Nanotechnology 2019 Feb 4;30(5):054005. Epub 2018 Dec 4.

Solid State Physics and NanoLund, Lund University, Lund, Sweden.

Controllable particle assisted growth (PAG) of III-V nanowires is today almost exclusively done with Au, Ga or In nanoparticles, whereas other metals often yield nanowires with uncontrolled growth directions. To improve the control of the initial growth direction in PAG, independent of choice of metal, we propose to initiate nanowire growth from a group-III-rich foreign metal particle. For III-V nanowire growth, the group III concentration of the particle can be made to increase or decrease with the relative supply of group III and group V material, which can be used to promote the liquid phase that is necessary for vapor-liquid-solid growth. Read More

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February 2019

A Solution for the Shortage of Detection Dogs: A Detector Dog Center of Excellence and a Cooperative Breeding Program.

Front Vet Sci 2018 16;5:284. Epub 2018 Nov 16.

Penn Vet Working Dog Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Currently, demand for US-bred and born detector dogs exceeds available supply, while reliance on foreign-bred sources introduces many unnecessary and unwanted risks. With proper management of a domestic supply line, U.S. Read More

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November 2018

I Want My Bullet Back: Percutaneous Endovascular Removal of a Right Atrial Foreign Body.

Cureus 2018 Sep 26;10(9):e3367. Epub 2018 Sep 26.

Interventional Radiology, University of Florida College of Medicine, Jacksonville, USA.

The incidence and prevalence of firearm-related homicide in the United States make headlines daily. As a result, an epidemic of penetrating injuries is on the rise. Specifically, foreign bodies such as bullets and shrapnel are usually left inside the human body due to penetrating injuries, unless they are in close proximity to vital structures. Read More

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September 2018
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Effect of cooking on glycemic index, antioxidant activities, α-amylase, and α-glucosidase inhibitory properties of two rice varieties.

Food Sci Nutr 2018 Nov 11;6(8):2301-2307. Epub 2018 Oct 11.

Functional Foods and Nutraceutical Research Unit Department of Biochemistry Federal University of Technology Akure Nigeria.

This study was designed to investigate the influence of cooking on the glycemic index (GI), amylose, and amylopectin contents of two rice varieties. Two rice varieties (foreign long rice and ofada) were sourced for, divided into two, one portion cooked and the other used raw. The sugar, starch, amylose, and amylopectin contents as well as glycemic indices, antioxidant properties, and the ability of the rice to inhibit carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase) were determined. Read More

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November 2018

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892;

The T cell antigen receptor encounters foreign antigen during the immune response. Receptor engagement leads to activation of specific protein tyrosine kinases, which then phosphorylate multiple enzymes and adapter proteins. One such enzyme, phospholipase-Cγ1, is responsible for cleavage of a plasma membrane lipid substrate, a phosphoinositide, into two second messengers, diacylglycerol, which activates several enzymes including protein kinase C, and an inositol phosphate, which induces intracellular calcium elevation. Read More

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December 2018