264,202 results match your criteria Foreign Bodies Nose
Sci China Life Sci 2018 Dec 13. Epub 2018 Dec 13.
State Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, 410081, China.
Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated and obtained the main rules regarding inheritance and reproduction related to fish distant hybridization. Read More
Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.
School of Foreign Languages, Hainan University, Haikou, 570228, China.
Salinity is one of the most important abiotic stresses, which affects the yield and quality of banana (Musa paradisiaca). To understand the salinity tolerance mechanisms of banana, the iTRAQ technique is employed to reveal the proteomic response of Brazil banana under different durations of 60 mmol/L NaCl stress. We have identified 77 DEPs and classified them into nine functional categories, compared with control (0 mmol/L NaCl treatment). Read More
J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.
Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.
Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More
Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.
Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More
Biomed Pharmacother 2019 Jan 7;109:2561-2572. Epub 2018 Dec 7.
School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address:
Multiple types of inflammations caused by foreign pathogens or chemicals and mutations that upregulate inflammation enhancers kindle the need of developing new vectors for the treatment of inflammation. Nanoparticles have been used in various fields ranging from the food industry, cosmetic industry and agricultural industry to devices like sensors, solar cells, and batteries. Nanoparticles have been used in the medical and research fields due to their high penetration power even inside cells and have the excellent ligand-binding properties due to their high surface area to volume ratio. Read More
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Plastic, Reconstructive, and Aesthetic Surgery Department of Mersin University Medical Faculty, Mersin, Turkey.
Ultra-thin porous polyethylene has been widely preferred in orbital blow out fracture repair for many years as a safe and stable material. Delayed complications related to the implant in orbital blow out fracture repair are very rare and usually begin as a periorbital inflammation. Infections and tissue reaction to the foreign body are regarded as main causes for implant-related inflammation of which symptoms may vary among the patients and may involve subacute and chronic eyelid swelling, skin redness, pain, conjunctival injection, proptosis, and acute orbital inflammation. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1817-1820
Department of Otorhinolaryngology, Affiliated Hospital of Yanbian University College of Medicine, Yanji, 133000, China.
Observation of the effect of uvuplopalatal flap for OSAHS patients with anterior and posterior pharyngeal stenosis. Fifty-six patients with OSAHS who were mainly anterior posterior stenosis in the velopharyngeal plane were selected. Patients with suspending uvuplopalatal flap were used as observation group (30 cases). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1432-1433
Ingestion of magnetic foreign bodies is an increasing problem in the pediatric emergency in recent years.The majority of these injuries are ingestions involving the gastrointestinal tract, stomach, esophagus etc.Ingestion of multiple magnets has a high risk of bowel injury such as perforation or fistula. Read More
Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More
Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.
College of Public Health Science (CPHS), Chulalongkorn University, Institute building 3 (10th-11th floor), Bangkok, Thailand.
Purpose: Community-based health insurance (CBHI) targets independent worker (self-employed) is currently struggling with inadequate size of risk pooling, low enrollment, and high dropout rate as well as financial sustainability. The objective of this study is to find out the factors that significantly affect the CBHI enrollment incentive. The study applied cross-sectional study design to perform situation analysis, in which the Andersen behavioral model was used as a guideline to identify preliminary characteristics that involved with enrolling incentive. Read More
Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.
Department of Economics, Hosei University, Tokyo, Japan.
Objectives: In Japan, strong reimbursement pricing control measures for existing medical device products have rendered new medical device reimbursement pricing critical for manufacturers. Few studies have been conducted on this aspect; therefore, this paper (1) clarifies whether evaluation of innovation is appropriate or not and (2), if not, investigates its background.
Methods: In this research, 319 C1/C2 government decisions for new medical devices in the 10 years from April 2008 to March 2018 were analyzed. Read More
J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.
Surgery, Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflammation and organ dysfunction following trauma; however, less is known about the effects of a foreign body on local trauma and tissue damage. We hypothesized that tracheal damage secondary to the ETT will result in local release of mtDNA at sufficient levels to induce TLR9 and NF-κB activation. Read More
Macromol Biosci 2018 Dec 13:e1800322. Epub 2018 Dec 13.
Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/IV, 11000, Belgrade, Serbia.
Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Read More
Angew Chem Int Ed Engl 2018 Dec 12. Epub 2018 Dec 12.
Yonsei University, Department of Physics, 50 Yonsei-ro, Seodaemun-gu, 120-749, Seoul, KOREA, REPUBLIC OF.
Black phosphorus (BP) has received much attention due to its fascinating properties, such as a high mobility and tunable band gap which covers the band gap lacuna between graphene and transition metal dichalcogenides. However, these advantages have been overshadowed due to the fast degradation of BP in ambient conditions. To overcome this obstacle, the degradation mechanisms should be unveiled with direct observation followed by a thorough analysis. Read More
Transfusion 2018 Dec 12. Epub 2018 Dec 12.
Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia.
Background: Alloimmunization is a known risk of transfusion therapy caused by exposure to foreign RBC antigens. However, alloimmunization is not observed in all transfused patients. Human leukocyte antigen (HLA) molecules may contribute to the recognition and presentation of foreign antigens and to the potency of immune responses that result in the production of antibodies. Read More
J Gen Virol 2018 Dec 14. Epub 2018 Dec 14.
Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Street, Harbin 150069, PR China.
In this study, ten sites on the N terminus and different surface variable regions (VRs) of the bovine parvovirus (BPV) VP2 capsid protein were selected according to an alignment of its sequence with that of the BPV-1 strain HADEN for insertion of the type O foot-and-mouth disease virus (FMDV) conserved neutralizing epitope 8E8. Ten epitope-chimeric BPV VP2 capsid proteins carrying the 8E8 epitope were expressed in Sf9 cells, and electron micrographs demonstrated that these fusion proteins self-assembled into virus-like particles (VLPs) with properties similar to those of natural BPV virions. Immunofluorescence assay (IFA) and Western blot analysis demonstrated that each of the ten epitope-chimeric VLPs reacted with both anti-BPV serum and anti-type O FMDV mAb 8E8. Read More
Methods Mol Biol 2019 ;1894:1-29
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More
J Community Health 2018 Dec 13. Epub 2018 Dec 13.
Program in Public Health, University of California, Irvine, Irvine, CA, USA.
The foreign-born black population contributes a considerable amount of heterogeneity to the US black population. In 2005, black immigrants accounted for 20% of the US black population. Compared to native-born black women, black immigrant women are at lower risk for adverse birth outcomes, including preterm birth. Read More
Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.
Incorrect title of the article. Read More
Soc Psychiatry Psychiatr Epidemiol 2018 Dec 13. Epub 2018 Dec 13.
Disparities Research Unit, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 830, Boston, MA, 02114, USA.
Purpose: There has been no comprehensive examination of how race/ethnicity and nativity intersect in explaining differences in lifetime prevalence of mental disorders among Asian, Black, Latino, and White adults. This study aims to estimate racial/ethnic differences in lifetime risk of mental disorders and examine how group differences vary by nativity.
Methods: Survival models were used to estimate racial/ethnic and nativity differences in lifetime risk of DSM-IV anxiety, mood, and substance use disorders in a nationally representative sample of over 20,000 respondents to four US surveys. Read More
Orthop J Sports Med 2018 Dec 4;6(12):2325967118811604. Epub 2018 Dec 4.
St John of God Hospital, Subiaco, Perth, Australia.
Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues.
Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Read More
J Glob Health 2018 Dec;8(2):020313
Department of Global Health Policy, University of Tokyo, Tokyo, Japan.
Popul Res Policy Rev 2018 31;37(6):1053-1077. Epub 2018 Jul 31.
School of Demography, Australian National University, 9 Fellows Road, Acton, ACT 2601 Australia.
Australia is a major immigration country and immigrants currently represent around 28% of the total population. The aim of this research is to understand the long-term consequences of this immigration and, particularly, how migrants respond to opportunities within the country after arriving through the process of subsequent (internal) migration. The focus is on major immigrant groups in Australia, including persons born in the United Kingdom, New Zealand, China and India, and how their patterns differ from persons born in Australia. Read More
Nat Rev Cardiol 2018 Dec 13. Epub 2018 Dec 13.
CVPath Institute, Gaithersburg, MD, USA.
Fully bioresorbable scaffolds (BRS) were designed to overcome the limitations of metallic drug-eluting stents, which permanently cage the vessel wall, thereby preventing normal coronary vasomotion, preclude bypass grafting and can provoke long-term foreign-body responses. Although multiple scaffolds have been or are in development, the Absorb Bioresorbable Vascular Scaffold (BVS; Abbott Vascular) was the first FDA-approved device and was widely expected to fulfil the dream of interventional cardiologists of a transient scaffold that would disappear 'when the job was done' and would not hamper further treatment options. Although early, small studies and even large, randomized trials showed beneficial outcomes up to 1 year of follow-up, longer-term results have been disappointing, with increased rates of device thrombosis and target-lesion revascularization. Read More
BMC Health Serv Res 2018 Dec 14;18(Suppl 3):927. Epub 2018 Dec 14.
Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.
Background: Healthcare institutions deliver essential services that practically everyone needs at least periodically over the course of their lives. Hospital admissions, in particular, place patients in circumstances very foreign to them, with uncertain outcomes often being the case, causing stress for care recipients and their loved ones. Health and medical establishments must be very mindful of this and work toward supplying environments that are as comforting as possible for those in their care. Read More
BMC Infect Dis 2018 Dec 13;18(1):655. Epub 2018 Dec 13.
Busan Center for Infectious Disease Control and Prevention, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, South Korea.
Background: This study investigated the treatment outcomes, and factors affecting the outcomes, of new tuberculosis (TB) patients in Busan, South Korea.
Methods: We retrospectively analysed the citywide TB registry data (collected for the Korean National TB Surveillance System) of new TB patients registered in Busan from January 2014 to December 2015.
Results: A total of 4732 patients were included in this study (mean age, 52. Read More
Int J Environ Res Public Health 2018 Dec 12;15(12). Epub 2018 Dec 12.
Department of Global Health, Research School of Population Health, Australian National University, Canberra, ACT 2600, Australia.
Performing arts used as a method of spreading health information dates back to the origins of storytelling. However, interventions in developing, non-Western countries typically utilize Western entertainment forms. This qualitative investigation assesses responses to an intervention designed around traditional Javanese shadow puppetry (). Read More
Pharmaceutics 2018 Dec 11;10(4). Epub 2018 Dec 11.
Emergency University Hospital, Bucharest, Romania, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease, stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly treated due to the difficulties associated with drug development, administration, and targeting to the brain. The existence of the blood-brain barrier, a selective permeability system which acts as a local gateway against circulating foreign substances, represents the key challenge for the delivery of therapeutic agents to the brain. However, the development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies. Read More
Mar Drugs 2018 Dec 7;16(12). Epub 2018 Dec 7.
Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Key Laboratory of Plant Epigenetic, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
The green alga was recently been shown to be an effective bio-manufacturing platform for the production of recombinant proteins. The advantage of using is that it is fast to grow, inexpensive to culture, and relatively safe. However, the expression of foreign proteins is always low and difficult to purify in . Read More
J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.
Department of Prosthodontics, Faculty of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast, unwanted peri-implant bone loss. We have previously hypothesized on the participation of immune mechanisms in such processes, and later demonstrated enhanced bone immune activation up to 4 weeks around titanium implants. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13575
Department of General Surgery, Linyi People's Hospital, Linyi, Shandong Province, China.
Femoral hernias (FHs), predominantly seen in females, require surgery for cure. To date, surgical repair of primary FHs in female patients with either open surgery or laparoscopic operation has been poorly documented. We retrospectively investigated the treatment of female primary FHs with open surgery using the ULTRAPRO Hernia System (UHS procedure) or the laparoscopic procedure, namely, the transabdominal preperitoneal (TAPP) technique. Read More
J Mol Biol 2018 Dec 10. Epub 2018 Dec 10.
Department of Biochemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117 Budapest, Hungary. Electronic address:
Reversible serine proteinase inhibitors comprise 18 unrelated families. Each family has a distinct representative structure, but contains a surface loop that adopts the same, canonical conformation in the enzyme-inhibitor complex. The Laskowski-mechanism universally applies for the action of all canonical inhibitors independent of their scaffold, but it has two nontrivial extrapolations. Read More
Hinyokika Kiyo 2018 Nov;64(11):451-453
The Department of Urology, Dokkyo Medical University Saitama Medical Center.
We describe the first case of a 25-year-old patient with gender identity disorder (GID) who underwent cryopreservation of sperm prior to male-to-female (MTF) sex reassignment surgery in Japan. The patient wanted to freeze sperm to keep open the option of conceiving a child in the future. The ethics committee of our institution discussed the case and officially approved cryopreservation of sperm before sex reassignment surgery. Read More
Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):e32-e45
Appropriate regeneration of periodontal tissues is the primary purpose of periodontal disease treatment. The present study assessed the impact of three key regenerative elements-platelet-rich plasma (PRP), canine bone marrow mesenchymal stem cells (cBM-MSCs), and fibrin glue-on periodontal regeneration. In each of the study's five dogs, Class II furcation defects were established on the buccal surface of five teeth. Read More
J Pediatr Hematol Oncol 2018 Dec 12. Epub 2018 Dec 12.
Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health.
Background: Autoimmune thrombocytopenia in immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and heparin-induced thrombocytopenia (HIT) is associated with immunologic degradation of platelets and reduced platelet counts in patients, leading to bleeding risk in patients. Considering the role of human leukocyte antigens (HLA) in the development of immune response, in this review, we examine the relationship between HLA and pathogenesis of the above-mentioned diseases.
Methods: Relevant English-language literature was searched and retrieved from Google Scholar search engine and PubMed database (1979 to 2018). Read More
Nanoscale 2018 Dec 13. Epub 2018 Dec 13.
Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0511, USA.
Defect/active site control is crucial for tuning the chemical, optical, and electronic properties of MoS2, which can adjust the performance of MoS2 in application areas such as electronics, optics, catalysis, and molecular sensing. This study presents an effective method of inducing defect/active sites, including micro/nanofractured structures and S atomic vacancies, on monolayer MoS2 flakes by using femtosecond laser pulses, through which physical-chemical adsorption and charge transfer between foreign molecules (O2 or R6G molecules) and MoS2 are enhanced. The enhanced charge transfer between foreign molecules (O2 or R6G) and femtosecond laser-treated MoS2 can enhance the electronic doping effect between them, hence resulting in a photoluminescence photon energy shift (reaching 0. Read More
Methods Mol Biol 2019 ;1902:67-73
Henan Collaborative Innovation Center of Modern Biological Breeding, Henan Institute of Sciences and Technology, Xinxiang, Henan, China.
Although many gene transfer methods have been employed for successfully obtaining transgenic cotton, the major constraint in cotton improvement is the limitation of genotype because the majority of transgenic methods require plant regeneration from a single transformed cell which is limited by cotton tissue culture. Comparing with other plant species, it is difficult to induce plant regeneration from cotton; currently, only a limited number of cotton cultivars can be cultured for obtaining regenerated plants. Thus, developing a simple and genotype-independent genetic transformation method is particularly interested for cotton. Read More
Methods Mol Biol 2019 ;1902:19-33
Department of Biology, East Carolina University, Greenville, NC, USA.
There are many methods and techniques that can be used to transfer foreign genes into cells. In plant biotechnology, Agrobacterium-mediated transformation is a widely used traditional method for inserting foreign genes into plant genome and obtaining transgenic plants, particularly for dicot plant species. Agrobacterium-mediated transformation of cotton involves several important and also critical steps, which includes co-culture of cotton explants with Agrobacterium, induction and selection of stable transgenic cell lines, recovery of plants from transgenic cells majorly through somatic embryogenesis, and detection and expression analysis of transgenic plants. Read More
Glob Pediatr Health 2018 14;5:2333794X18811795. Epub 2018 Nov 14.
Indiana University, Indianapolis, IN, USA.
. To understand the perspectives of clinical providers and caregivers regarding early childhood development (ECD) in children born to HIV-infected mothers in Kenya. . Read More
Front Psychol 2018 27;9:2301. Epub 2018 Nov 27.
Department of Cultures and Civilizations, University of Verona, Verona, Italy.
Clitic production is reported to be challenging for impaired children, suffering from dyslexia or SLI, and for early second language learners too. On the contrary, research has not directly investigated the relation between dyslexia, bilingualism and clitic production. The aim of our study is that of addressing this topic, by analyzing the performance of 4 groups of children in a clitic elicitation task: 25 Italian monolingual dyslexic children (mean age 10;08 years old), 33 Italian monolingual typically developing children (9;99 years old), 25 bilingual dyslexic children with Italian as L2 (10;31 years old) and 31 bilingual typically developing children with Italian as L2 (10;30 years old). Read More
Turk J Med Sci 2018 12 12;48(6):1268-1277. Epub 2018 Dec 12.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, İstanbul University, İstanbul, Turkey
Background/aim: This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement
(CTBC) and chitosan, on the healing of experimental bone defects.
Materials And Methods: Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that
consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. Read More
Nihon Ronen Igakkai Zasshi 2018 ;55(4):668-674
Department of Internal Medicine II, Shimane University, Faculty of Medicine.
An 84-year-old male with dysphagia was referred to our hospital. Chest computed tomography (CT) showed a rectangular structure along with artificial air in the cervical esophagus. Endoscopy revealed a 'shogi' game piece in the same region shown in CT findings, which was recovered during the endoscopic procedure. Read More
J Immunol 2018 Dec 12. Epub 2018 Dec 12.
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853;
Therapeutic strategies based on in vitro-transcribed mRNA (IVT) are attractive because they avoid the permanent signature of genomic integration that is associated with DNA-based therapy and result in the transient production of proteins of interest. To date, IVT has mainly been used in vaccination protocols to generate immune responses to foreign Ags. In this "proof-of-principle" study, we explore a strategy of combinatorial IVT to recruit and reprogram immune effector cells to acquire divergent biological functions in mice in vivo. Read More
J Immunol 2018 Dec 12. Epub 2018 Dec 12.
Department of Microbiology and Immunology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and
MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR engagement and TCR-mediated signaling has not been systematically studied. To evaluate the role of MHC clustering, we exploited nanoscale discoidal membrane mimetics (nanolipoprotein particles) to capture and present peptide-MHC (pMHC) ligands at various densities. Read More
J Virol 2018 Dec 12. Epub 2018 Dec 12.
Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Engineered recombinant viruses expressing reporter genes have been developed for real-time monitoring of replication and for mass screening of anti-viral inhibitors. Recently, we reported using a reverse genetics system to develop the first recombinant reporter rotaviruses (RVs) that expressed NanoLuc (NLuc) luciferase. Here, we describe a strategy for developing stable reporter RVs expressing luciferase and green or red fluorescent proteins. Read More
mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.
Foreign Animal Disease Research Unit, USDA-ARS, Plum Island Animal Disease Center, Greenport, New York, USA
The pathogenesis of foot-and-mouth disease virus (FMDV) in cattle was investigated through early and late stages of infection by use of an optimized experimental model for controlled contact exposure. Time-limited exposure of cattle to FMDV-infected pigs led to primary FMDV infection of the nasopharyngeal mucosa in both vaccinated and nonvaccinated cattle. In nonvaccinated cattle, the infection generalized rapidly to cause clinical disease, without apparent virus amplification in the lungs prior to establishment of viremia. Read More
Cir Esp 2018 Dec 9. Epub 2018 Dec 9.
Cirugía General y Digestivo, Hospital Universitario Los Arcos del Mar Menor, San Javier, Murcia, España.
Front Med (Lausanne) 2018 20;5:321. Epub 2018 Nov 20.
Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
The balance between systemic anticoagulation and clotting is challenging. In normal hemostasis, the endothelium regulates the balance between anticoagulant and prothrombotic systems. It becomes particularly more challenging to maintain this physiologic hemostasis when we are faced with extracorporeal life support therapies, where blood is continuously in contact with a foreign extracorporeal circuit surface predisposing a prothrombotic state. Read More
Iran J Public Health 2018 Oct;47(10):1604
School of Foreign Languages, Shanghai Jiao Tong University, Shanghai, China.
Iran J Public Health 2018 Oct;47(10):1593-1598
Dept. of Biologic Statistics, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: This study was designed to rank factors affecting attraction of foreign medical tourists based on marketing mix model.
Methods: In this descriptive study, data were collected through a questionnaire. Foreign patients, hospitalized from Jan 2015 to Sep 2016 in all hospitals of Mashhad were chosen as the study population (13 hospitals). Read More