264,201 results match your criteria Foreign Bodies Ear


Differential proteomic analysis reveals the mechanism of Musa paradisiaca responding to salt stress.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

School of Foreign Languages, Hainan University, Haikou, 570228, China.

Salinity is one of the most important abiotic stresses, which affects the yield and quality of banana (Musa paradisiaca). To understand the salinity tolerance mechanisms of banana, the iTRAQ technique is employed to reveal the proteomic response of Brazil banana under different durations of 60 mmol/L NaCl stress. We have identified 77 DEPs and classified them into nine functional categories, compared with control (0 mmol/L NaCl treatment). Read More

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December 2018
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F-FDG-PET/CT-guided treatment duration in patients with high-risk Staphylococcus aureus bacteremia: a proof of principle.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.

Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More

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December 2018

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims.

Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More

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December 2018

Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review.

Biomed Pharmacother 2019 Jan 7;109:2561-2572. Epub 2018 Dec 7.

School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address:

Multiple types of inflammations caused by foreign pathogens or chemicals and mutations that upregulate inflammation enhancers kindle the need of developing new vectors for the treatment of inflammation. Nanoparticles have been used in various fields ranging from the food industry, cosmetic industry and agricultural industry to devices like sensors, solar cells, and batteries. Nanoparticles have been used in the medical and research fields due to their high penetration power even inside cells and have the excellent ligand-binding properties due to their high surface area to volume ratio. Read More

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January 2019

Usefulness of pre-travel medical examination and vaccination.

Authors:
Hiroshi Watanabe

Nihon Rinsho 2016 Dec;74(12):2047-2051

At present, both the number of Japanese travelers to foreign countries and foreign travel- ers who visit Japan are remarkably increasing. Travel clinic for travelers is well-known in western countries and medical consultation, vaccination, prescription, etc are performed, but that is not popular in Japan yet. Most Japanese travelers to foreign countries do not necessa- rily collect any information concerning the infectious diseases which are endemic in the des- tination and security related with their travel and hesitates to receive the recommended vac- cines or prophylactic for malaria. Read More

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December 2016

Surveillance data in overseas-Comparison with Japan-.

Nihon Rinsho 2016 Dec;74(12):1962-1966

Measures for emerging and re-emerging infectious diseases are the world's common chal- lenges. It is important to construct an effective infection control and medical care system to understand the occurrence and the mode of transmission of emerging and re-emerging infec- tious diseases. However, it is feared the invasion of pathogens from abroad than ever before. Read More

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December 2016

Nephrology Nursing in Rwanda: Creating the Future Through Education and Organizational Partnership.

Nephrol Nurs J 2016 Jul-Aug;43(4):311-315

Visiting Faculty at University of Rwanda and ICU Clinical Educator at Rwanda Military Hospital, Human Resources for Health Program in partnership with the New York University Rory Meyers College of Nursing.

The Human Resources for Health Program was launched in Rwanda in 2012 as a sevenyear initiative to improve healthcare services and decrease overall dependence on foreign aid. In partnership between U.S. Read More

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December 2018

A Rare Cause for Recurrent Implant-Related Inflammation of Orbit: Dacryocystitis.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Plastic, Reconstructive, and Aesthetic Surgery Department of Mersin University Medical Faculty, Mersin, Turkey.

Ultra-thin porous polyethylene has been widely preferred in orbital blow out fracture repair for many years as a safe and stable material. Delayed complications related to the implant in orbital blow out fracture repair are very rare and usually begin as a periorbital inflammation. Infections and tissue reaction to the foreign body are regarded as main causes for implant-related inflammation of which symptoms may vary among the patients and may involve subacute and chronic eyelid swelling, skin redness, pain, conjunctival injection, proptosis, and acute orbital inflammation. Read More

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December 2018
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[Uvuplopalatal flap in OSAHS patients with anteriorand posterior pharyngeal plane stenosis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1817-1820

Department of Otorhinolaryngology, Affiliated Hospital of Yanbian University College of Medicine, Yanji, 133000, China.

Observation of the effect of uvuplopalatal flap for OSAHS patients with anterior and posterior pharyngeal stenosis. Fifty-six patients with OSAHS who were mainly anterior posterior stenosis in the velopharyngeal plane were selected. Patients with suspending uvuplopalatal flap were used as observation group (30 cases). Read More

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December 2018

[A case of magnetic pharyngeal foreign body in children].

Authors:
X R Zhang Q Li

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1432-1433

Ingestion of magnetic foreign bodies is an increasing problem in the pediatric emergency in recent years.The majority of these injuries are ingestions involving the gastrointestinal tract, stomach, esophagus etc.Ingestion of multiple magnets has a high risk of bowel injury such as perforation or fistula. Read More

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September 2018

Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.

Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More

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December 2018

Factors affecting the willingness to join community-based health insurance (CBHI) scheme: A case study survey from Savannakhet Province, Lao P.D.R.

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

College of Public Health Science (CPHS), Chulalongkorn University, Institute building 3 (10th-11th floor), Bangkok, Thailand.

Purpose: Community-based health insurance (CBHI) targets independent worker (self-employed) is currently struggling with inadequate size of risk pooling, low enrollment, and high dropout rate as well as financial sustainability. The objective of this study is to find out the factors that significantly affect the CBHI enrollment incentive. The study applied cross-sectional study design to perform situation analysis, in which the Andersen behavioral model was used as a guideline to identify preliminary characteristics that involved with enrolling incentive. Read More

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December 2018

Reimbursement pricing for new medical devices in Japan: Is the evaluation of innovation appropriate?

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, Hosei University, Tokyo, Japan.

Objectives: In Japan, strong reimbursement pricing control measures for existing medical device products have rendered new medical device reimbursement pricing critical for manufacturers. Few studies have been conducted on this aspect; therefore, this paper (1) clarifies whether evaluation of innovation is appropriate or not and (2), if not, investigates its background.

Methods: In this research, 319 C1/C2 government decisions for new medical devices in the 10 years from April 2008 to March 2018 were analyzed. Read More

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December 2018

Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF-κB activity.

J Leukoc Biol 2018 Dec 13. Epub 2018 Dec 13.

Surgery, Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflammation and organ dysfunction following trauma; however, less is known about the effects of a foreign body on local trauma and tissue damage. We hypothesized that tracheal damage secondary to the ETT will result in local release of mtDNA at sufficient levels to induce TLR9 and NF-κB activation. Read More

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December 2018

Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs.

Macromol Biosci 2018 Dec 13:e1800322. Epub 2018 Dec 13.

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/IV, 11000, Belgrade, Serbia.

Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Read More

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December 2018

Intrinsic correlation between electronic structure and degradation: from few layers to bulk black phosphorus.

Angew Chem Int Ed Engl 2018 Dec 12. Epub 2018 Dec 12.

Yonsei University, Department of Physics, 50 Yonsei-ro, Seodaemun-gu, 120-749, Seoul, KOREA, REPUBLIC OF.

Black phosphorus (BP) has received much attention due to its fascinating properties, such as a high mobility and tunable band gap which covers the band gap lacuna between graphene and transition metal dichalcogenides. However, these advantages have been overshadowed due to the fast degradation of BP in ambient conditions. To overcome this obstacle, the degradation mechanisms should be unveiled with direct observation followed by a thorough analysis. Read More

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December 2018

Susceptible and protective HLA-DR and HLA-DQ alleles for Fy alloimmunization in the Croatian population.

Transfusion 2018 Dec 12. Epub 2018 Dec 12.

Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia.

Background: Alloimmunization is a known risk of transfusion therapy caused by exposure to foreign RBC antigens. However, alloimmunization is not observed in all transfused patients. Human leukocyte antigen (HLA) molecules may contribute to the recognition and presentation of foreign antigens and to the potency of immune responses that result in the production of antibodies. Read More

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December 2018

Potent neutralization activity against type O foot-and-mouth disease virus elicited by a conserved type O neutralizing epitope displayed on bovine parvovirus virus-like particles.

J Gen Virol 2018 Dec 14. Epub 2018 Dec 14.

Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Street, Harbin 150069, PR China.

In this study, ten sites on the N terminus and different surface variable regions (VRs) of the bovine parvovirus (BPV) VP2 capsid protein were selected according to an alignment of its sequence with that of the BPV-1 strain HADEN for insertion of the type O foot-and-mouth disease virus (FMDV) conserved neutralizing epitope 8E8. Ten epitope-chimeric BPV VP2 capsid proteins carrying the 8E8 epitope were expressed in Sf9 cells, and electron micrographs demonstrated that these fusion proteins self-assembled into virus-like particles (VLPs) with properties similar to those of natural BPV virions. Immunofluorescence assay (IFA) and Western blot analysis demonstrated that each of the ten epitope-chimeric VLPs reacted with both anti-BPV serum and anti-type O FMDV mAb 8E8. Read More

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December 2018

The story of the lost needle: Foreign body embolization to the heart.

J Cardiol Cases 2015 Jun 2;11(6):175-177. Epub 2015 Apr 2.

University of Miami Miller School of Medicine, Department of Cardiology, Miami, FL, USA.

A 61-year-old female was evaluated because of severe symptomatic mitral regurgitation. She was found to have a foreign body in the heart by cardiac catheterization. Through a retrospective review of serial imaging studies, we found that a hypodermic needle had been retained in the body from a prior abdominal wall surgery and had subsequently migrated to the heart. Read More

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BioGlue coronary embolism during open heart surgery.

J Cardiol Cases 2014 Aug 25;10(2):78-80. Epub 2014 Jun 25.

Cardiovascular Division, Osaka Minami Medical Center, Osaka, Japan.

In cases of iatrogenic coronary embolism during cardiac surgery or percutaneous coronary intervention, small air bubbles or foreign bodies are directly injected, which usually result in serious adverse events if not treated promptly. We herein describe the case of a patient who developed acute myocardial infarction resulting in shock due to BioGlue (CryoLife, Atlanta, GA, USA)-induced coronary embolism during the surgical repair of aortic dissection and was treated for retrieval of the material using a thrombectomy catheter. < Coronary embolism caused by surgical adhesives is a rare but potentially life-threatening complication. Read More

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FOREIGN BODIES IN THE URINARY BLADDER - CASE SERIES.

J West Afr Coll Surg 2017 Jul-Sep;7(3):124-136

Department of Surgery, Federal Teaching Hospital, Abakaliki, Nigeria.

Foreign bodies get into the bladder by self insertion, migration or as a component of iatrogenic and penetrating injuries. Diagnosis and treatment pose great challenges to the urologist especially if they are radiolucent. A common pattern of presentation is with lower urinary tract symptoms. Read More

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December 2018

In Vitro Methods for Assessing Nanoparticle Toxicity.

Methods Mol Biol 2019 ;1894:1-29

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More

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January 2019

An Examination of Preterm Birth and Residential Social Context among Black Immigrant Women in California, 2007-2010.

J Community Health 2018 Dec 13. Epub 2018 Dec 13.

Program in Public Health, University of California, Irvine, Irvine, CA, USA.

The foreign-born black population contributes a considerable amount of heterogeneity to the US black population. In 2005, black immigrants accounted for 20% of the US black population. Compared to native-born black women, black immigrant women are at lower risk for adverse birth outcomes, including preterm birth. Read More

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December 2018

Correction to: Intracranial foreign material granuloma after neurosurgical procedures.

Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.

Incorrect title of the article. Read More

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December 2018

Race/ethnicity, nativity, and lifetime risk of mental disorders in US adults.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Disparities Research Unit, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 830, Boston, MA, 02114, USA.

Purpose: There has been no comprehensive examination of how race/ethnicity and nativity intersect in explaining differences in lifetime prevalence of mental disorders among Asian, Black, Latino, and White adults. This study aims to estimate racial/ethnic differences in lifetime risk of mental disorders and examine how group differences vary by nativity.

Methods: Survival models were used to estimate racial/ethnic and nativity differences in lifetime risk of DSM-IV anxiety, mood, and substance use disorders in a nationally representative sample of over 20,000 respondents to four US surveys. Read More

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December 2018

Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study.

Orthop J Sports Med 2018 Dec 4;6(12):2325967118811604. Epub 2018 Dec 4.

St John of God Hospital, Subiaco, Perth, Australia.

Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues.

Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Read More

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December 2018
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Subsequent Migration of Immigrants Within Australia, 1981-2016.

Popul Res Policy Rev 2018 31;37(6):1053-1077. Epub 2018 Jul 31.

School of Demography, Australian National University, 9 Fellows Road, Acton, ACT 2601 Australia.

Australia is a major immigration country and immigrants currently represent around 28% of the total population. The aim of this research is to understand the long-term consequences of this immigration and, particularly, how migrants respond to opportunities within the country after arriving through the process of subsequent (internal) migration. The focus is on major immigrant groups in Australia, including persons born in the United Kingdom, New Zealand, China and India, and how their patterns differ from persons born in Australia. Read More

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Fully bioresorbable vascular scaffolds: lessons learned and future directions.

Nat Rev Cardiol 2018 Dec 13. Epub 2018 Dec 13.

CVPath Institute, Gaithersburg, MD, USA.

Fully bioresorbable scaffolds (BRS) were designed to overcome the limitations of metallic drug-eluting stents, which permanently cage the vessel wall, thereby preventing normal coronary vasomotion, preclude bypass grafting and can provoke long-term foreign-body responses. Although multiple scaffolds have been or are in development, the Absorb Bioresorbable Vascular Scaffold (BVS; Abbott Vascular) was the first FDA-approved device and was widely expected to fulfil the dream of interventional cardiologists of a transient scaffold that would disappear 'when the job was done' and would not hamper further treatment options. Although early, small studies and even large, randomized trials showed beneficial outcomes up to 1 year of follow-up, longer-term results have been disappointing, with increased rates of device thrombosis and target-lesion revascularization. Read More

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December 2018

Establishing Good Samaritan programs in healthcare institutions: a method for enhancing patient experiences and increasing loyalty.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):927. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Healthcare institutions deliver essential services that practically everyone needs at least periodically over the course of their lives. Hospital admissions, in particular, place patients in circumstances very foreign to them, with uncertain outcomes often being the case, causing stress for care recipients and their loved ones. Health and medical establishments must be very mindful of this and work toward supplying environments that are as comforting as possible for those in their care. Read More

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December 2018
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Treatment outcomes and factors affecting treatment outcomes of new patients with tuberculosis in Busan, South Korea: a retrospective study of a citywide registry, 2014-2015.

BMC Infect Dis 2018 Dec 13;18(1):655. Epub 2018 Dec 13.

Busan Center for Infectious Disease Control and Prevention, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, South Korea.

Background: This study investigated the treatment outcomes, and factors affecting the outcomes, of new tuberculosis (TB) patients in Busan, South Korea.

Methods: We retrospectively analysed the citywide TB registry data (collected for the Korean National TB Surveillance System) of new TB patients registered in Busan from January 2014 to December 2015.

Results: A total of 4732 patients were included in this study (mean age, 52. Read More

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December 2018
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Shadow Puppets and Neglected Diseases (2): A Qualitative Evaluation of a Health Promotion Performance in Rural Indonesia.

Int J Environ Res Public Health 2018 Dec 12;15(12). Epub 2018 Dec 12.

Department of Global Health, Research School of Population Health, Australian National University, Canberra, ACT 2600, Australia.

Performing arts used as a method of spreading health information dates back to the origins of storytelling. However, interventions in developing, non-Western countries typically utilize Western entertainment forms. This qualitative investigation assesses responses to an intervention designed around traditional Javanese shadow puppetry (). Read More

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December 2018

Blood-Brain Delivery Methods Using Nanotechnology.

Pharmaceutics 2018 Dec 11;10(4). Epub 2018 Dec 11.

Emergency University Hospital, Bucharest, Romania, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease, stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly treated due to the difficulties associated with drug development, administration, and targeting to the brain. The existence of the blood-brain barrier, a selective permeability system which acts as a local gateway against circulating foreign substances, represents the key challenge for the delivery of therapeutic agents to the brain. However, the development of nanotechnology-based approaches for brain delivery, such as nanoparticles, liposomes, dendrimers, micelles, and carbon nanotubes, might be the solution for improved brain therapies. Read More

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December 2018

Biosynthesis and Secretion of Human Tissue Kallikrein in Transgenic .

Mar Drugs 2018 Dec 7;16(12). Epub 2018 Dec 7.

Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Key Laboratory of Plant Epigenetic, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

The green alga was recently been shown to be an effective bio-manufacturing platform for the production of recombinant proteins. The advantage of using is that it is fast to grow, inexpensive to culture, and relatively safe. However, the expression of foreign proteins is always low and difficult to purify in . Read More

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December 2018

Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Department of Prosthodontics, Faculty of Odontology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast, unwanted peri-implant bone loss. We have previously hypothesized on the participation of immune mechanisms in such processes, and later demonstrated enhanced bone immune activation up to 4 weeks around titanium implants. Read More

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December 2018

Laparoscopic transabdominal preperitoneal technique versus open surgery with the ULTRAPRO Hernia System for the repair of female primary femoral hernias-an observational retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13575

Department of General Surgery, Linyi People's Hospital, Linyi, Shandong Province, China.

Femoral hernias (FHs), predominantly seen in females, require surgery for cure. To date, surgical repair of primary FHs in female patients with either open surgery or laparoscopic operation has been poorly documented. We retrospectively investigated the treatment of female primary FHs with open surgery using the ULTRAPRO Hernia System (UHS procedure) or the laparoscopic procedure, namely, the transabdominal preperitoneal (TAPP) technique. Read More

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December 2018

Directed Evolution of Canonical Loops and their Swapping between Unrelated Serine Proteinase Inhibitors Disprove the Interscaffolding Additivity Model.

J Mol Biol 2018 Dec 10. Epub 2018 Dec 10.

Department of Biochemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117 Budapest, Hungary. Electronic address:

Reversible serine proteinase inhibitors comprise 18 unrelated families. Each family has a distinct representative structure, but contains a surface loop that adopts the same, canonical conformation in the enzyme-inhibitor complex. The Laskowski-mechanism universally applies for the action of all canonical inhibitors independent of their scaffold, but it has two nontrivial extrapolations. Read More

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December 2018

[Sperm Cryopreservation for a Gender Identity Disorder Patient Prior to Sex Reassignment Surgery : A Case Report].

Hinyokika Kiyo 2018 Nov;64(11):451-453

The Department of Urology, Dokkyo Medical University Saitama Medical Center.

We describe the first case of a 25-year-old patient with gender identity disorder (GID) who underwent cryopreservation of sperm prior to male-to-female (MTF) sex reassignment surgery in Japan. The patient wanted to freeze sperm to keep open the option of conceiving a child in the future. The ethics committee of our institution discussed the case and officially approved cryopreservation of sperm before sex reassignment surgery. Read More

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November 2018

Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Fibrin Glue for Periodontal Regeneration.

Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):e32-e45

Appropriate regeneration of periodontal tissues is the primary purpose of periodontal disease treatment. The present study assessed the impact of three key regenerative elements-platelet-rich plasma (PRP), canine bone marrow mesenchymal stem cells (cBM-MSCs), and fibrin glue-on periodontal regeneration. In each of the study's five dogs, Class II furcation defects were established on the buccal surface of five teeth. Read More

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December 2018
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The Association Between Human Leukocyte Antigens and ITP, TTP, and HIT.

J Pediatr Hematol Oncol 2018 Dec 12. Epub 2018 Dec 12.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health.

Background: Autoimmune thrombocytopenia in immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and heparin-induced thrombocytopenia (HIT) is associated with immunologic degradation of platelets and reduced platelet counts in patients, leading to bleeding risk in patients. Considering the role of human leukocyte antigens (HLA) in the development of immune response, in this review, we examine the relationship between HLA and pathogenesis of the above-mentioned diseases.

Methods: Relevant English-language literature was searched and retrieved from Google Scholar search engine and PubMed database (1979 to 2018). Read More

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December 2018

Enhancing charge transfer with foreign molecules through femtosecond laser induced MoS defect sites for photoluminescence control and SERS enhancement.

Nanoscale 2018 Dec 13. Epub 2018 Dec 13.

Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0511, USA.

Defect/active site control is crucial for tuning the chemical, optical, and electronic properties of MoS2, which can adjust the performance of MoS2 in application areas such as electronics, optics, catalysis, and molecular sensing. This study presents an effective method of inducing defect/active sites, including micro/nanofractured structures and S atomic vacancies, on monolayer MoS2 flakes by using femtosecond laser pulses, through which physical-chemical adsorption and charge transfer between foreign molecules (O2 or R6G molecules) and MoS2 are enhanced. The enhanced charge transfer between foreign molecules (O2 or R6G) and femtosecond laser-treated MoS2 can enhance the electronic doping effect between them, hence resulting in a photoluminescence photon energy shift (reaching 0. Read More

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December 2018

Pollen Tube Pathway-Mediated Cotton Transformation.

Methods Mol Biol 2019 ;1902:67-73

Henan Collaborative Innovation Center of Modern Biological Breeding, Henan Institute of Sciences and Technology, Xinxiang, Henan, China.

Although many gene transfer methods have been employed for successfully obtaining transgenic cotton, the major constraint in cotton improvement is the limitation of genotype because the majority of transgenic methods require plant regeneration from a single transformed cell which is limited by cotton tissue culture. Comparing with other plant species, it is difficult to induce plant regeneration from cotton; currently, only a limited number of cotton cultivars can be cultured for obtaining regenerated plants. Thus, developing a simple and genotype-independent genetic transformation method is particularly interested for cotton. Read More

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January 2019

Agrobacterium-Mediated Genetic Transformation of Cotton.

Authors:
Baohong Zhang

Methods Mol Biol 2019 ;1902:19-33

Department of Biology, East Carolina University, Greenville, NC, USA.

There are many methods and techniques that can be used to transfer foreign genes into cells. In plant biotechnology, Agrobacterium-mediated transformation is a widely used traditional method for inserting foreign genes into plant genome and obtaining transgenic plants, particularly for dicot plant species. Agrobacterium-mediated transformation of cotton involves several important and also critical steps, which includes co-culture of cotton explants with Agrobacterium, induction and selection of stable transgenic cell lines, recovery of plants from transgenic cells majorly through somatic embryogenesis, and detection and expression analysis of transgenic plants. Read More

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January 2019

Early Childhood Development in Children Born to HIV-Infected Mothers: Perspectives From Kenyan Clinical Providers and Caregivers.

Glob Pediatr Health 2018 14;5:2333794X18811795. Epub 2018 Nov 14.

Indiana University, Indianapolis, IN, USA.

. To understand the perspectives of clinical providers and caregivers regarding early childhood development (ECD) in children born to HIV-infected mothers in Kenya. . Read More

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November 2018

The Production of Clitic Pronouns: A Study on Bilingual and Monolingual Dyslexic Children.

Front Psychol 2018 27;9:2301. Epub 2018 Nov 27.

Department of Cultures and Civilizations, University of Verona, Verona, Italy.

Clitic production is reported to be challenging for impaired children, suffering from dyslexia or SLI, and for early second language learners too. On the contrary, research has not directly investigated the relation between dyslexia, bilingualism and clitic production. The aim of our study is that of addressing this topic, by analyzing the performance of 4 groups of children in a clitic elicitation task: 25 Italian monolingual dyslexic children (mean age 10;08 years old), 33 Italian monolingual typically developing children (9;99 years old), 25 bilingual dyslexic children with Italian as L2 (10;31 years old) and 31 bilingual typically developing children with Italian as L2 (10;30 years old). Read More

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November 2018

The histopathological effects of calcium triglyceride bone cement and chitosan on the healing of experimental bone defects

Turk J Med Sci 2018 12 12;48(6):1268-1277. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, İstanbul University, İstanbul, Turkey

Background/aim: This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement (CTBC) and chitosan, on the healing of experimental bone defects.

Materials And Methods: Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. Read More

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December 2018

[Diagnostic significance of computed tomography findings of foreign body in esophagus].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):668-674

Department of Internal Medicine II, Shimane University, Faculty of Medicine.

An 84-year-old male with dysphagia was referred to our hospital. Chest computed tomography (CT) showed a rectangular structure along with artificial air in the cervical esophagus. Endoscopy revealed a 'shogi' game piece in the same region shown in CT findings, which was recovered during the endoscopic procedure. Read More

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January 2018

Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo.

J Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853;

Therapeutic strategies based on in vitro-transcribed mRNA (IVT) are attractive because they avoid the permanent signature of genomic integration that is associated with DNA-based therapy and result in the transient production of proteins of interest. To date, IVT has mainly been used in vaccination protocols to generate immune responses to foreign Ags. In this "proof-of-principle" study, we explore a strategy of combinatorial IVT to recruit and reprogram immune effector cells to acquire divergent biological functions in mice in vivo. Read More

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December 2018

Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.

J Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Immunology and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and

MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR engagement and TCR-mediated signaling has not been systematically studied. To evaluate the role of MHC clustering, we exploited nanoscale discoidal membrane mimetics (nanolipoprotein particles) to capture and present peptide-MHC (pMHC) ligands at various densities. Read More

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December 2018
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Development of stable rotavirus reporter expression systems.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Engineered recombinant viruses expressing reporter genes have been developed for real-time monitoring of replication and for mass screening of anti-viral inhibitors. Recently, we reported using a reverse genetics system to develop the first recombinant reporter rotaviruses (RVs) that expressed NanoLuc (NLuc) luciferase. Here, we describe a strategy for developing stable reporter RVs expressing luciferase and green or red fluorescent proteins. Read More

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December 2018