140,909 results match your criteria Foot and Ankle Clinics [Journal]


Adherence to Therapeutic Footwear in Type 2 Diabetes in Malta.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Health Sciences, University of Malta.

Background: The literature reports that people living with diabetes do not adhere to their prescribed therapeutic footwear as instructed. The reason for this is still uncertian although certain footwear characteristics seem to reasons reported leading to reduced level of adherence.

Objectives: To explore the reasons for current adherence or otherwise to prescribed stock footwear amongst patients living with type-2 diabetes. Read More

View Article
December 2018

RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China.

Nanocrystals has been constructed for insoluble drugs as a novel type of nanoscale drug delivery systems with high drug loading. How to prepare nanocrystals with good stability and tumor targeting capability is still challenging. This study was to modify paclitaxel nanocrystals with polyethylene glycol (PEG) for stabilization and RGD peptide for tumor targeting. Read More

View Article
December 2018

Long Term Follow Up of a Vascularized Osteocutaneous Free Flap for Reconstruction in Charcot Neuroarthropathy: A Case Report.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD.

Vascularized osteocutaneous free flaps have seen increasing use in foot and ankle surgery for the repair of bony defects secondary to chronic nonunion, osteomyelitis, and fractures. One example is the Medial Femoral Condyle (MFC) Flap. The utility of the MFC flap for the repair of a bony defect in a diabetic patient, however, has yet to be explored. Read More

View Article
December 2018

An MMP/TIMP ratio scoring system as a potential predictive marker of diabetic foot ulcer healing.

J Wound Care 2018 Dec;27(12):849-855

Assistant Professor, Division of Plastic and Reconstructive Surgery, Lerdsin Hospital, Bangkok 10500, Thailand.

Objectives:: The mechanism of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in diabetic foot ulcers (DFUs) is unclear. The purpose of this study was to describe changes in MMP-1, MMP-9, and TIMP-1 levels during DFU healing, and to search for any correlation in the changes in MMP levels with wound healing, in order to find possible predictors of healing.

Methods:: Patients with a DFU were recruited and placed into two groups, according to the degree of wound healing: 'good healers' and 'poor healers'. Read More

View Article
December 2018

Photobiomodulation therapy in neuroischaemic diabetic foot ulcers: a novel method of limb salvage.

J Wound Care 2018 Dec;27(12):837-842

Assistant Professor-Senior Scale, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective:: Low-level laser therapy (also known as photobiomodulation therapy, PBMT) promotes accelerated healing of diabetic foot ulcers (DFUs), thereby preventing the risk of future complications and amputation. The aim of this study was to determine the effect of PBMT, with structured, graded mobilisation and foot care, on DFU healing dynamics.

Method:: Patients diagnosed with type 2 diabetes, diabetic peripheral neuropathy and presenting with a chronic neuroischaemic DFU, were treated with PBMT using scanning and non-contact probe methods. Read More

View Article
December 2018

Cryopreserved amniotic membrane in the treatment of diabetic foot ulcers: a case series.

J Wound Care 2018 Dec;27(12):806-815

Department of General Surgery, Hospital Clínico Universitario Virgen de la Arrixaca. Biomedical Research Institute of Murcia (Instituto Murciano de Investigación Biosanitaria, IMIB-Arrixaca). El Palmar, Spain.

Objective:: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti-inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes.

Method:: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. Read More

View Article
December 2018

Skin Integrity and Infection Prevention Las Vegas: continuous delivery of oxygen enhances closure of diabetic foot ulcers.

Authors:

J Wound Care 2018 Dec;27(12):856-857

The 4th International Skin Integrity and Infection Prevention conference, hosted by the Journal of Wound Care and the University of Huddersfield in Las Vegas, included a series of sponsored symposia. This is the third in our series of reports on the key points of the symposia, which outlined the effects of hypoxia on wound healing, and how reduced oxygen levels can lead to chronic, non-healing wounds. The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device. Read More

View Article
December 2018
1 Read

Diabetic foot ulcer treatment with focused shockwave therapy: two multicentre, prospective, controlled, double-blinded, randomised phase III clinical trials.

J Wound Care 2018 Dec;27(12):822-836

Calvary Hospital, Bronx, NY, US.

Objective:: To investigate the efficacy of focused extracorporeal shockwave therapy (ESWT) as an adjunctive treatment for neuropathic diabetic foot ulcers (DFU) (1A or 2A on the University of Texas grading scheme), compared with sham treatment.

Method:: We performed two multicentre, randomised, sham-controlled, double-blinded, phase III clinical trials using focused ESWT compared with sham examining DFUs that did not reduce in volume by ≥50% over 2 weeks' standard treatment immediately prior to randomisation. Patients were enrolled into the trials and randomised for either standard care and focused ESWT (pulsed acoustic cellular expression. Read More

View Article
December 2018

Investigation of galectin-3 levels in diabetic foot ulcers.

J Wound Care 2018 Dec;27(12):843-848

Professor, Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Objective:: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Read More

View Article
December 2018

A new unilateral abduction orthosis for Ponseti-treated clubfoot: A cohort study to assess compliance.

Prosthet Orthot Int 2018 Dec 17:309364618814866. Epub 2018 Dec 17.

2 Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, UK.

Background:: The Ponseti method for treating congenital talipes equinovarus requires an orthosis to maintain correction after manipulation and casting, typically the 'boots and bar'. Non-compliance with the orthosis increases the risk of recurrent deformity. This study investigates a new orthosis, the abduction dorsiflexion mechanism. Read More

View Article
December 2018
1 Read

Cost-Utility Study of the Economics of Bunion Correction Surgery.

Foot Ankle Int 2018 Dec 17:1071100718815663. Epub 2018 Dec 17.

3 Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Background:: Bunion correction surgery is a very common procedure to improve patients' pain and physical function attributable to a misaligned first metatarsophalangeal joint. The objective of this study was to apply a health utility framework to estimate the cost utility of bunion correction surgery.

Methods:: Patients were prospectively recruited from the population of patients seen in a lower-extremity orthopedic clinic and scheduled for isolated bunion surgery. Read More

View Article
December 2018

The biomechanical characteristics of high-performance endurance running.

Eur J Sport Sci 2018 Dec 15:1-9. Epub 2018 Dec 15.

a Centre for Health Sciences Research , University of Salford , Manchester , UK.

The biomechanical profile of high-level endurance runners may represent a useful model that could be used for developing training programmes designed to improve running style. This study, therefore, sought to compare the biomechanical characteristics of high-performance and recreational runners. Kinematic and kinetic measurements were taken during overground running from a cohort of 14 high-performance (8 male) and 14 recreational (8 male) runners, at four speeds ranging from 3. Read More

View Article
December 2018

Are Fibular Locking Plates Necessary? The Influence of Dogma.

Foot Ankle Int 2018 Dec 17:1071100718815660. Epub 2018 Dec 17.

1 Beth Israel Deaconess Medical Center, Boston, MA, USA.

View Article
December 2018

Strength Measurement After Achilles Tendon Repair.

Foot Ankle Spec 2018 Dec 17:1938640018819779. Epub 2018 Dec 17.

Department of Orthopedic Surgery, New York Presbyterian/Columbia University Medical Center, New York, NY.

The goal of treatment after Achilles tendon rupture (ATR) is to restore appropriate tension to the tendon, so that normal baseline strength and functional soft-tissue length can be achieved. The assessment of plantarflexion strength has shown widespread variability. The purpose of this study is to document variations in strength assessment after the treatment of ATR in the literature. Read More

View Article
December 2018

Effectiveness of custom-made foot orthoses in patients with rheumatoid arthritis: a randomized controlled trial.

Clin Rehabil 2018 Dec 17:269215518819118. Epub 2018 Dec 17.

1 Department of Podiatry, University of Seville, Seville, Spain.

Objective:: To determine the effect of custom-made foot orthoses versus placebo insoles on pain, disability, foot functionality, and quality of life.

Design:: Double-blinded randomized controlled trial.

Setting:: University Podiatric Clinical Area. Read More

View Article
December 2018

Outcome of Second-Ray Pathologies Following Weil Osteotomy in Patients Treated for Hallux Valgus.

Foot Ankle Spec 2018 Dec 17:1938640018819778. Epub 2018 Dec 17.

Department of Foot and Ankle Surgery, Eulji Medical Center, Eulji University, Seoul, Korea.

Background: We hypothesized that the cause of second-ray pathology with hallux valgus is excessive relative length of the second metatarsal and performed Weil osteotomy to shorten it, with correction of hallux valgus. The purpose of this study is to evaluate the outcome of second-ray pathology after distal chevron osteotomy (DCO) with Weil osteotomy to correct metatarsal parabola.

Methods: We performed concomitant Weil osteotomy of the second metatarsal with DCO of the first metatarsal as part of hallux valgus with second-ray pathology correction surgery in 45 feet (40 patients). Read More

View Article
December 2018

Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

We investigated the effects of photobiomodulation therapy (PBMT) and conditioned medium (CM) of human bone marrow mesenchymal stem cells (hBM-MSC) individually and/or in combination on the stereological parameters and the expression of basic fibroblast growth factor (bFGF), hypoxia-inducible factor (HIF-1α), and stromal cell-derived factor-1α (SDF-1α) in a wound model infected with methicillin-resistant Staphylococcus aureus (MRSA) in diabetic rats. CM was provided by culturing hBM-MSCs. Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups, harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM + PBMT. Read More

View Article
December 2018
1 Read

Comparison of changes in shoulder functions between biceps tenotomy and tenodesis in an animal model.

Asia Pac J Sports Med Arthrosc Rehabil Technol 2019 Jan 29;15:17-22. Epub 2018 Nov 29.

Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objectives: Tenotomy and tenodesis of the long head of biceps tendon are effective pain-relieving treatments. However, there is no consensus on the functional outcome after these surgical procedures. We hypothesized that there would be no difference in ambulation parameters after recovery from the surgery between rats that underwent tenotomy versus tenodesis procedures. Read More

View Article
January 2019

Minimally Invasive Osteosynthesis of Distal Tibia Fractures using Anterolateral Locking Plate.

Authors:
P Choudhari D Padia

Malays Orthop J 2018 Nov;12(3):38-42

Department of Orthopaedics, Sri Aurobindo Medical College and Post Graduate Institute, Indore, India.

Plating in distal tibia fractures are associated with higher rate of soft tissue complications. As adequate soft tissue cover is available over anterolateral surface of the tibia, use of anterolateral plate fixation in distal tibia fractures has increased. The purpose of our research is to evaluate the outcomes of anterolateral locking plate fixation in distal tibia fractures using ORIF. Read More

View Article
November 2018
1 Read

Ankle Arthrodesis using Ilizarov Ring Fixator: A Primary or Salvage Procedure? An Analysis of Twenty Cases.

Malays Orthop J 2018 Nov;12(3):24-30

Section of Orthopaedics, Aga Khan University Hospital, Karachi, Pakistan.

Ankle arthrodesis using the Ilizarov technique provides high union rate with the added benefits of early weight-bearing, and the unique advantage of its ability to promote regeneration of soft tissue around the bone, including skin, muscle and neuro-vascular structures, and its versatility to allow correction of the position of the foot by adjusting the frame post-operatively as needed. We describe our experience with this technique and the functional outcomes in our patients. This retrospective study was conducted in 20 ankle fusion cases using the Ilizarov method between the years 2007 and 2017. Read More

View Article
November 2018

Correlation of Foot Bimalleolar Angle and Ultrasonography in Assessing the Severity of Club Foot in Neonates Treated by the Ponseti Method.

Malays Orthop J 2018 Nov;12(3):14-18

Department of Orthopaedics, University College of Medical Sciences, Delhi, India.

Correlation of Pirani score and foot bimalleolar (FBM) angle has been used in few studies but correlation of FBM angle with ultrasonography has never been evaluated so they are being correlated in assessing the severity of clubfoot in neonates treated by Ponseti method. Thirty-two feet with congenital talipes equinovarus (CTEV) deformity in neonates were prospectively treated by the Ponseti method. FBM angle and ultrasound parameters were measured three times i. Read More

View Article
November 2018

A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus.

Infez Med 2018 Dec;26(4):359-363

Laboratory Medicine, San Bassiano Hospital, AULSS 7 Pedemontana, Bassano del Grappa, Italy.

Diabetes mellitus is one of the serious conditions associated with necrotizing fasciitis, a severe bacterial skin infection that spreads quickly and is characterized by extensive necrosis of the deep and superficial fascia resulting in devascularization and necrosis of the associated tissues. In addition to debridement and aggressive surgery procedures, the effectiveness of therapy depends on choosing the appropriate antibacterial agents. Hence the key to successful management is an early and accurate diagnosis. Read More

View Article
December 2018

Non-invasive evaluation of sudomotor function in patients with myasthenia gravis.

Neurophysiol Clin 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosciences and Mental Health, Hospital de Santa Maria-CHLN, avenue Professor-Egas-Moniz, 1648-028 Lisbon, Portugal; IMM and Institute of Physiology, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Objectives: Myasthenia gravis (MG) is an autoimmune disease associated with antibodies against the nicotinic muscle acetylcholine receptor (AChR) at the neuromuscular junction. Dysautonomia has been previously described in MG. Electrochemical skin conductance (ESC), assessed by Sudoscan, is a non-invasive method that allows evaluation of sudomotor function. Read More

View Article
December 2018

Surgical treatment of lateral and posterior process fractures of the talus: Mid-term results of 15 cases after 7 years.

Foot Ankle Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Trauma Surgery, Otto-von-Guericke University, Leipziger Str. 44 Magdeburg, Germany.

Background: We retrospectively evaluated the mid-term results of surgery for talar process fractures (lateral and posterior processes) and exploratively analyzed parameters that potentially impact treatment outcomes.

Methods: Fifteen patients who underwent internal fixation (January 2000 to December 2015) were examined for radiological and clinical functional outcomes. The independent parameters evaluated were age, sex, extent of general injury, soft-tissue damage, surgical latency, and fracture type. Read More

View Article
November 2018

Is regional ankle block needed in conjunction with general anaesthesia for first ray surgery? A randomised controlled trial of ultrasound guided ankle block versus "blind" local infiltration.

Foot Ankle Surg 2018 Nov 28. Epub 2018 Nov 28.

Orthopaedic Surgery, Leicester General Hospital, University Hospitals of Leicester, Leicester, England, UK.

Background: Regional anaesthesia is commonly utilised for foot and ankle surgery. Debate remains at to the level of regional anaesthesia that is required. The objective of this study was to evaluate whether surgeon-delivered "blind" local anaesthetic infiltration around the first ray (metatarsal block without ultrasound guidance) was as effective as an ultrasound guided ankle block in providing post-operative analgesia after osseous first ray surgery performed under general anaesthetic. Read More

View Article
November 2018
3 Reads

Management of Isolated Anterior Tibial Tendon Rupture: A Systematic Review and Meta-Analysis.

J Foot Ankle Surg 2018 Dec 13. Epub 2018 Dec 13.

Medical Writer, Scriptum Medica, University Place, WA. Electronic address:

Rupture of the tibialis anterior tendon is a rare condition reported to occur most often spontaneously in patients >45 years of age. Diagnosis is often delayed due to transient pain at the time of rupture and the ability of the long extensors to compensate for the lost action of the tibialis anterior. Treatment has been proposed to be based on the activity level of the individual; however, no consensus has been reached on the optimal treatment modality for this rare condition. Read More

View Article
December 2018

Foot arch deformation and plantar fascia loading during running with rearfoot strike and forefoot strike: A dynamic finite element analysis.

J Biomech 2018 Dec 8. Epub 2018 Dec 8.

The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China. Electronic address:

Forefoot strike becomes popular among runners because it facilitates better impact attenuation. However, forefoot strike may overload the plantar fascia and impose risk of plantar fasciitis. This study aimed to examine and compare the foot arch deformation and plantar fascia tension between different foot strike techniques in running using a computational modelling approach. Read More

View Article
December 2018

Effect of age and speed on the step-to-step transition phase during walking.

J Biomech 2018 Dec 8. Epub 2018 Dec 8.

Laboratoire de physiologie et biomécanique de la locomotion, Institute of NeuroScience, Université catholique de Louvain, Louvain-la-Neuve, Belgium. Electronic address:

Gait is a powerful measurement tool to evaluate the functional decline throughout ageing. Falls in elderly adults happen mainly during the redirection of the center of mass of the body (CoM) in the transition between steps. In young adults, this step-to-step transition begins before the double contact phase (DC) with a simultaneous forward and upward acceleration of the CoM. Read More

View Article
December 2018

Photoplethysmographic characterization of vascular tone mediated changes in arterial pressure: an observational study.

J Clin Monit Comput 2018 Dec 15. Epub 2018 Dec 15.

Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

To determine whether a classification based on the contour of the photoplethysmography signal (PPGc) can detect changes in systolic arterial blood pressure (SAP) and vascular tone. Episodes of normotension (SAP 90-140 mmHg), hypertension (SAP > 140 mmHg) and hypotension (SAP < 90 mmHg) were analyzed in 15 cardiac surgery patients. SAP and two surrogates of the vascular tone, systemic vascular resistance (SVR) and vascular compliance (Cvasc = stroke volume/pulse pressure) were compared with PPGc. Read More

View Article
December 2018
1 Read

Clinical Comparison Between Shortening Osteotomy of the Proximal Phalanx Neck and Arthrodesis in Hammer Toe Surgery at Mid-TermFollow-Up.

J Foot Ankle Surg 2018 Dec 13. Epub 2018 Dec 13.

Professor, Department of Orthopaedics & Traumatology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.

The treatment of hammer toe has been advocated for years, and many procedures have been proposed with skeletal and soft tissue intervention. The purpose of the present study was to compare arthrodesis of the proximal interphalangeal joint with shortening osteotomy of the proximal phalanx neck. In most cases, both procedures have been associated with elongation of the extensor apparatus, capsulotomy of the metatarsophalangeal joint, and stabilization with a Kirschner wire. Read More

View Article
December 2018
1 Read

Preoperative Assessment of the Peroneal Tendons in Lateral Ankle Instability: Examining Clinical Factors, Magnetic Resonance Imaging Sensitivity, and Their Relationship.

J Foot Ankle Surg 2018 Dec 12. Epub 2018 Dec 12.

Assistant Professor, Department of Surgery, Division of Orthopaedics, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

The purpose of our study was to examine the preoperative clinical factors and magnetic resonance imaging (MRI) findings associated with peroneal pathology in chronic lateral ankle instability patients, as well as the clinical factors associated with peroneal lesions being detected on MRI. Peroneal pathology was determined from intraoperative findings. Patients with/without peroneal pathology were compared regarding their preoperative clinical findings. Read More

View Article
December 2018

Modified Valenti Arthroplasty in Running and Jumping Athletes With Hallux Limitus/Rigidus: Analysis of One Hundred Procedures.

J Foot Ankle Surg 2018 Dec 12. Epub 2018 Dec 12.

Podiatrist, Podiatry Associates, PC Castle Pines, CO.

Despite hallux limitus/rigidus being a common condition, results of surgical procedures specifically pertaining to athletes are scarce. The results of 100 modified Valenti procedures, prospectively studied from January 2000 to June 2016 with an average 49.17 months of follow-up, are presented evaluating demographics, sport, time and ability to return to activity (RTA), decreased desired activity level, and need for additional surgery. Read More

View Article
December 2018

Clinical and radiographic outcomes of a hybrid fixation revision total knee arthroplasty system at short to mid-term follow-up.

Knee 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Section of Orthopaedics, University of Manitoba, Winnipeg, Manitoba, Canada; Concordia Joint Replacement Group, Concordia Hip & Knee Institute, Winnipeg, Manitoba, Canada. Electronic address:

Background: Despite the extensive study of primary arthroplasty, revision surgery is rarely discussed due to the reduced frequency and variability between patients. A new revision knee system was introduced to build off the geometry of a successful knee replacement system. This study seeks to assess the survival, clinical outcomes and radiographic assessment of this revision system at the early to mid-term. Read More

View Article
December 2018

l-Theanine and NEP1-40 promote nerve regeneration and functional recovery after brachial plexus root avulsion.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun, 130012, China. Electronic address:

Brachial plexus root avulsion causes severe sequelae Treatments and prognosis face many problems, including inflammatory reaction, oxidative damage, and myelin related inhibitory effect. l-Theanine has anti-inflammatory, anti-oxidative, and neuroprotective effects. NEP1-40 competitively inhibits Nogo-66 receptor (NgR1) promotes axonal regeneration. Read More

View Article
December 2018

Drivers who don't comply with a minimum passing distance rule when passing bicycle riders.

J Safety Res 2018 Dec 19;67:183-188. Epub 2018 Oct 19.

Queensland University of Technology (QUT), Centre for Accident Research and Road Safety, Queensland, Australia; Queensland University of Technology (QUT), Institute of Health and Biomedical Innovation, Australia.

Introduction: Drivers' passing cyclists closely can contribute to crashes, falls, and intimidation, which may discourage cycling. In response, minimum passing distance (MPD) rules have been introduced in many jurisdictions. This study examined the factors associated with non-compliance with a MPD rule. Read More

View Article
December 2018

Saphenous nerve block for medial foot surgery: Saphenous nerve beyond cutaneous sensory distribution.

J Clin Anesth 2018 Dec 12;54:160-161. Epub 2018 Dec 12.

Department of Anesthesiology, Perioperative, and Pain Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, CA, United States. Electronic address:

View Article
December 2018

Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex.

Neuroscience 2018 Dec 12. Epub 2018 Dec 12.

School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Brisbane, Australia; Center for the Study of Traumatic Stress, Department of Psychiatry, USU School of Medicine, Bethesda, MD, USA. Electronic address:

Debilitating and persistent fear memories can rapidly form in humans following exposure to traumatic events. Fear memories can also be generated and studied in animals via Pavlovian fear conditioning. The current study was designed to evaluate basolateral amygdala complex involvement following the formation of different fear memories (two contextual fear memories and one adjusted auditory fear memory). Read More

View Article
December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

View Article
December 2018
1 Read

Effective mucosal live attenuated Salmonella vaccine by deleting phosphotransferase system component genes ptsI and crr.

J Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Read More

View Article
October 2018
1 Read

Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

View Article
December 2018
1 Read

Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

View Article
December 2018
1 Read

Corrigendum: Spatial and temporal distribution of foot-and-mouth disease in four districts situated along the Uganda-Tanzania border: Implications for cross-border efforts in disease control.

Onderstepoort J Vet Res 2018 Dec 11;85(1):1716. Epub 2018 Dec 11.

Nelson Mandela African Institute of Science and Technology, Arusha, Tanzania; and, National Livestock Resources Research Institute, Tororo, Uganda.

No abstract available. Read More

View Article
December 2018
1.260 Impact Factor

Cadmium bioaccumulation and elimination in tissues of the freshwater mussel Anodonta woodiana.

Chemosphere 2018 Dec 6;219:321-327. Epub 2018 Dec 6.

School of Life Science, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:

Experiments were carried out to investigate the bioaccumulation and elimination of cadmium (Cd) in tissues (kidney, gills, digestive gland, mantle, visceral mass, foot, adductor muscle and hemolymph) from the freshwater mussel, Anodonta woodiana. The mussels were exposed to subchronic Cd at concentrations of 0.168 and 0. Read More

View Article
December 2018

Kinematics reduction applied to the comparison of highly-pronated, normal and highly-supinated feet during walking.

Gait Posture 2018 Dec 6;68:269-273. Epub 2018 Dec 6.

Departamento de Ingeniería Mecánica y Construcción, Universitat Jaume I, Av. Vicent Sos Baynat, s/n, 12071, Castellón, Spain. Electronic address:

Background: Kinematic analysis could help to study how variations in the static foot posture affect lower limb biomechanical function. The analysis of foot kinematics is complex because it involves managing the time-dependent joint angles in different joints and in all three planes of motion. But it could be simplified if joint angles are coordinated. Read More

View Article
December 2018
1 Read

Effects of heel height and high-heel experience on foot stability during quiet standing.

Gait Posture 2018 Dec 5;68:252-257. Epub 2018 Dec 5.

Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hunghom, Hong Kong. Electronic address:

Background: The use of high-heeled shoes (HHS) introduces instability into the wearer's balance system but how high-heel experience might influence standing balance is less examined in literature.

Research Question: (1) Does foot stability decrease in both the antero-posterior (AP) and medial-lateral (ML) directions with increasing heel height during quiet standing? (2) Does high-heel experience improve the wearer's foot stability during quiet standing in high-heeled conditions?

Methods: Twenty-four young females (12 regular and 12 non-regular HHS wearers) were recruited to perform quiet standing while wearing shoes with heel heights of 1 cm, 5 cm, 8 cm and 10 cm. The effects of heel height on the mean center of pressure (COP), their variability (standard deviations) and mean COP velocities in both the AP and ML directions were analysed by one-way repeated measures ANOVA and Bonferroni post-hoc test. Read More

View Article
December 2018

Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: inpatients and outpatients.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More

View Article
December 2018
1 Read

Spatiotemporal decomposition and risk determinants of hand, foot and mouth disease in Henan, China.

Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.

China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:

Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More

View Article
December 2018
3 Reads

More expression, less function: cleaved dynamin in glomerular kidney disease.

J Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, Rush University Medical Center, Chicago, IL, USA.

The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes. Destruction of dynamin, for example by cathepsin L, leads to loss of a functional actin network and uncoordinated membrane signaling, a situation that allows for effacement of foot processes and proteinuria. Read More

View Article
December 2018
1 Read

Motor Neuroprostheses.

Authors:
Arthur Prochazka

Compr Physiol 2018 Dec 13;9(1):127-148. Epub 2018 Dec 13.

Neuroscience and Mental Health Institute (NMHI), School of Molecular & Systems Medicine, University of Alberta, Edmonton, Alberta, Canada.

Neuroprostheses (NPs) are electrical stimulators that activate nerves, either to provide sensory input to the central nervous system (sensory NPs), or to activate muscles (motor NPs: MNPs). The first MNPs were belts with inbuilt batteries and electrodes developed in the 1850s to exercise the abdominal muscles. They became enormously popular among the general public, but as a result of exaggerated therapeutic claims they were soon discredited by the medical community. Read More

View Article
December 2018
2 Reads

Influence of reduced tip-apex distance on helical blade fixation - a biomechanical study.

J Orthop Res 2018 Dec 13. Epub 2018 Dec 13.

AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.

Migration profile of helical blades differs from conventional screw design. Tip-apex distance (TAD) greater than 25mm is associated with early failure in hip screws. This study investigates the effect of a reduced TAD on helical blade fixation. Read More

View Article
December 2018