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Saphenous nerve block for medial foot surgery: Saphenous nerve beyond cutaneous sensory distribution.

J Clin Anesth 2018 Dec 12;54:160-161. Epub 2018 Dec 12.

Department of Anesthesiology, Perioperative, and Pain Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, CA, United States. Electronic address:

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December 2018

Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex.

Neuroscience 2018 Dec 12. Epub 2018 Dec 12.

School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, Brisbane, Australia; Center for the Study of Traumatic Stress, Department of Psychiatry, USU School of Medicine, Bethesda, MD, USA. Electronic address:

Debilitating and persistent fear memories can rapidly form in humans following exposure to traumatic events. Fear memories can also be generated and studied in animals via Pavlovian fear conditioning. The current study was designed to evaluate basolateral amygdala complex involvement following the formation of different fear memories (two contextual fear memories and one adjusted auditory fear memory). Read More

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December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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December 2018
1 Read

Effective mucosal live attenuated Salmonella vaccine by deleting phosphotransferase system component genes ptsI and crr.

J Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Read More

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October 2018
1 Read

Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

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December 2018

Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

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December 2018
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Corrigendum: Spatial and temporal distribution of foot-and-mouth disease in four districts situated along the Uganda-Tanzania border: Implications for cross-border efforts in disease control.

Onderstepoort J Vet Res 2018 Dec 11;85(1):1716. Epub 2018 Dec 11.

Nelson Mandela African Institute of Science and Technology, Arusha, Tanzania; and, National Livestock Resources Research Institute, Tororo, Uganda.

No abstract available. Read More

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December 2018
1.260 Impact Factor

Cadmium bioaccumulation and elimination in tissues of the freshwater mussel Anodonta woodiana.

Chemosphere 2018 Dec 6;219:321-327. Epub 2018 Dec 6.

School of Life Science, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:

Experiments were carried out to investigate the bioaccumulation and elimination of cadmium (Cd) in tissues (kidney, gills, digestive gland, mantle, visceral mass, foot, adductor muscle and hemolymph) from the freshwater mussel, Anodonta woodiana. The mussels were exposed to subchronic Cd at concentrations of 0.168 and 0. Read More

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December 2018

Kinematics reduction applied to the comparison of highly-pronated, normal and highly-supinated feet during walking.

Gait Posture 2018 Dec 6;68:269-273. Epub 2018 Dec 6.

Departamento de Ingeniería Mecánica y Construcción, Universitat Jaume I, Av. Vicent Sos Baynat, s/n, 12071, Castellón, Spain. Electronic address:

Background: Kinematic analysis could help to study how variations in the static foot posture affect lower limb biomechanical function. The analysis of foot kinematics is complex because it involves managing the time-dependent joint angles in different joints and in all three planes of motion. But it could be simplified if joint angles are coordinated. Read More

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December 2018

Effects of heel height and high-heel experience on foot stability during quiet standing.

Gait Posture 2018 Dec 5;68:252-257. Epub 2018 Dec 5.

Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hunghom, Hong Kong. Electronic address:

Background: The use of high-heeled shoes (HHS) introduces instability into the wearer's balance system but how high-heel experience might influence standing balance is less examined in literature.

Research Question: (1) Does foot stability decrease in both the antero-posterior (AP) and medial-lateral (ML) directions with increasing heel height during quiet standing? (2) Does high-heel experience improve the wearer's foot stability during quiet standing in high-heeled conditions?

Methods: Twenty-four young females (12 regular and 12 non-regular HHS wearers) were recruited to perform quiet standing while wearing shoes with heel heights of 1 cm, 5 cm, 8 cm and 10 cm. The effects of heel height on the mean center of pressure (COP), their variability (standard deviations) and mean COP velocities in both the AP and ML directions were analysed by one-way repeated measures ANOVA and Bonferroni post-hoc test. Read More

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December 2018

Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: inpatients and outpatients.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More

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December 2018
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Spatiotemporal decomposition and risk determinants of hand, foot and mouth disease in Henan, China.

Sci Total Environ 2018 Dec 5;657:509-516. Epub 2018 Dec 5.

China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:

Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More

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December 2018
1 Read

More expression, less function: cleaved dynamin in glomerular kidney disease.

J Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, Rush University Medical Center, Chicago, IL, USA.

The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes. Destruction of dynamin, for example by cathepsin L, leads to loss of a functional actin network and uncoordinated membrane signaling, a situation that allows for effacement of foot processes and proteinuria. Read More

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December 2018

Motor Neuroprostheses.

Authors:
Arthur Prochazka

Compr Physiol 2018 Dec 13;9(1):127-148. Epub 2018 Dec 13.

Neuroscience and Mental Health Institute (NMHI), School of Molecular & Systems Medicine, University of Alberta, Edmonton, Alberta, Canada.

Neuroprostheses (NPs) are electrical stimulators that activate nerves, either to provide sensory input to the central nervous system (sensory NPs), or to activate muscles (motor NPs: MNPs). The first MNPs were belts with inbuilt batteries and electrodes developed in the 1850s to exercise the abdominal muscles. They became enormously popular among the general public, but as a result of exaggerated therapeutic claims they were soon discredited by the medical community. Read More

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December 2018
2 Reads

Influence of reduced tip-apex distance on helical blade fixation - a biomechanical study.

J Orthop Res 2018 Dec 13. Epub 2018 Dec 13.

AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.

Migration profile of helical blades differs from conventional screw design. Tip-apex distance (TAD) greater than 25mm is associated with early failure in hip screws. This study investigates the effect of a reduced TAD on helical blade fixation. Read More

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December 2018

Potent neutralization activity against type O foot-and-mouth disease virus elicited by a conserved type O neutralizing epitope displayed on bovine parvovirus virus-like particles.

J Gen Virol 2018 Dec 14. Epub 2018 Dec 14.

Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Street, Harbin 150069, PR China.

In this study, ten sites on the N terminus and different surface variable regions (VRs) of the bovine parvovirus (BPV) VP2 capsid protein were selected according to an alignment of its sequence with that of the BPV-1 strain HADEN for insertion of the type O foot-and-mouth disease virus (FMDV) conserved neutralizing epitope 8E8. Ten epitope-chimeric BPV VP2 capsid proteins carrying the 8E8 epitope were expressed in Sf9 cells, and electron micrographs demonstrated that these fusion proteins self-assembled into virus-like particles (VLPs) with properties similar to those of natural BPV virions. Immunofluorescence assay (IFA) and Western blot analysis demonstrated that each of the ten epitope-chimeric VLPs reacted with both anti-BPV serum and anti-type O FMDV mAb 8E8. Read More

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December 2018

Is Use of Bone Cement for Treatment of Second Metatarsal Stress Fractures Safe? A Case Report.

Cureus 2018 Oct 9;10(10):e3436. Epub 2018 Oct 9.

Orthopaedics, University of Alabama at Birmingham, Birmingham, USA.

Metatarsal stress fractures are common injuries of the foot and can be a source of chronic pain without appropriate management. Conservative management is first line, but surgery may be indicated in athletes, cases of nonunion, and fractures of the fifth metatarsal. We report a case of a 34-year-old female who presented to clinic for intractable pain of the left foot secondary to a stress fracture of the left second metatarsal, which had been previously treated with injectable acrylic bone cement. Read More

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October 2018
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Estimating Recent Local Impacts of Sea-Level Rise on Current Real-Estate Losses: A Housing Market Case Study in Miami-Dade, Florida.

Popul Res Policy Rev 2018 26;37(6):871-895. Epub 2018 Jun 26.

2Environmental Health Sciences, Columbia University's Mailman School of Public Health, New York, NY USA.

Sea-Level Rise (SLR) Projections from the National Oceanic and Atmospheric Administration (NOAA) and the U.S. Army Corp of Engineers (USACE) indicate increasing, and imminent, risk to coastal communities from tidal flooding and hurricane storm surge. Read More

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Integrative approach for diabetic foot management- a case report.

J Ayurveda Integr Med 2018 Dec 10. Epub 2018 Dec 10.

Institute of Ayurveda and Integrative Medicine, Trans Disciplinary University, No.74/2, Jarakabandekaval Post Attur, Via Yelahanka, Bangalore, 560 064, Karnataka, India.

Non-healing diabetic foot has always demanded more attention from the surgeon due to the distinct problem it possesses. There is a constant need for the evolvement in the management and this case is one such attempt. A 62-year-old male patient with a history of diabetes mellitus since 10 years presented with a non-healing foot ulcer since 1 month. Read More

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December 2018

Evaluation of postural stability based on a force plate and inertial sensor during static balance measurements.

J Physiol Anthropol 2018 Dec 13;37(1):27. Epub 2018 Dec 13.

Department of Industrial Engineering and Management, Yuan Ze University, 135 Yuan Tung Road, Chungli District, Taoyuan, 320, Republic of China.

Background: Previous research on balance mostly focused on the assessment, training, and improvements of balance through interventions. We investigated tools commonly used to study static balance. Differences in postural stability were analyzed using multiscale entropy (MSE) and feature analysis. Read More

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December 2018

Spatiotemporal Gait Analysis and Lower Limb Functioning in Foot Dystonia Treated with Botulinum Toxin.

Toxins (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Head John Walsh Centre for Rehabilitation Research, Sydney Medical School, University of Sydney, Sydney 2006, Australia.

Foot dystonia (FD) is a disabling condition causing pain, spasm and difficulty in walking. We treated fourteen (14) adult patients experiencing FD with onabotulinum toxin A injection into the dystonic foot muscles. We analyzed the spatiotemporal gait utilizing the GaitRite system pre- and 3 weeks post-botulinum toxin injection along with measuring dystonia by the Fahn⁻Marsden Dystonia Scale (FMDS), pain by the Visual Analog Scale (VAS) and other lower limb functional outcomes such as gait velocity, the Berg Balance Scale (BBS), the Unified Parkinson's Disease Rating Scale⁻Lower Limb Score (UPDRS⁻LL), the Timed Up and Go (TUG) test and the Goal Attainment Scale (GAS). Read More

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December 2018

Design of an Artificial Neural Network Algorithm for a Low-Cost Insole Sensor to Estimate the Ground Reaction Force (GRF) and Calibrate the Center of Pressure (CoP).

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

Motion Control Laboratory, School of Mechanical Engineering, Yonsei University, Seoul 03722, Korea.

As an alternative to high-cost shoe insole pressure sensors that measure the insole pressure distribution and calculate the center of pressure (CoP), researchers developed a foot sensor with FSR sensors on the bottom of the insole. However, the calculations for the center of pressure and ground reaction force (GRF) were not sufficiently accurate because of the fundamental limitations, fixed coordinates and narrow sensing areas, which cannot cover the whole insole. To address these issues, in this paper, we describe an algorithm of virtual forces and corresponding coordinates with an artificial neural network (ANN) for low-cost flexible insole pressure measurement sensors. Read More

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December 2018

Deformation Analysis of a Composite Bridge during Proof Loading Using Point Cloud Processing.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Gabriela Narutowicza 11/12, 80-233 Gdansk, Poland.

Remote sensing in structural diagnostics has recently been gaining attention. These techniques allow the creation of three-dimensional projections of the measured objects, and are relatively easy to use. One of the most popular branches of remote sensing is terrestrial laser scanning. Read More

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December 2018
1 Read

Non-dislocation lunate fracture combined with distal radius fracture: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13574

Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China.

Rationale: Lunate fractures are very rare, accounting for only 0.5% to 6.5% of all carpal fractures. Read More

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December 2018

Using Smart Socks to Detect Step-count at Slow Walking Speeds in Healthy Adults.

Int J Sports Med 2018 Dec 13. Epub 2018 Dec 13.

School of Allied Health Sciences, Griffith University, Gold Coast, Australia.

We examined the accuracy of Smart Socks - a device that measures foot pressure during gait for detecting step-count across various walking speeds. Thirty-six participants (17 men; 19 women) wore Smart Socks (Sock), a pedometer (Pedometer), and a smartphone with a commercially available Phone Application (Phone) pedometer to measure step-count during 3-min of treadmill or over-ground walking at 1.3, 2. Read More

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December 2018

Hepatic arterial therapy with oxaliplatin and systemic capecitabine for patients with liver metastases from breast cancer.

Breast 2018 Dec 5;43:113-119. Epub 2018 Dec 5.

Department of Oncology, Herlev & Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

Objectives: Hepatic arterial treatment (HAT) for liver metastases in patients with metastatic breast cancer (MBC) has only been investigated in few studies.

Materials And Methods: Two phase II trials were initiated simultaneously to evaluate capecitabine in combination with oxaliplatin in patients with MBC and liver metastases. These two trials are reported together. Read More

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December 2018

Deletion 7q21.2-q22.1 in a case with split hand-split foot malformation, sensorineural hearing loss and intellectual disability: Phenotype subtypes and the correlation with genotypes.

Eur J Med Genet 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India. Electronic address:

The split hand/split foot malformation (SHFM) or ectrodactyly is a rare congenital heterogeneous limb developmental disorder with at least 6 associated loci. It is characterized by absence of central rays of hands and feet and fusion of remaining digits. It can present as an isolated malformation or in combination with additional anomalies (non-syndromic or syndromic ectrodactyly). Read More

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December 2018

Active avoidance learning differentially activates ERK phosphorylation in the primary auditory and visual cortices of Roman high- and low-avoidance rats.

Physiol Behav 2018 Dec 10. Epub 2018 Dec 10.

Department of Life and Environmental Sciences, University of Cagliari, Italy. Electronic address:

Understanding the mechanisms underlying conditioned avoidance is a critical step toward the development of novel treatments of anxiety. In this context, the two-way active avoidance (2WAA) task is a validated paradigm to investigate uncontrolled avoidance, a hallmark of anxiety disorders. The outbred Roman high- (RHA) and low-avoidance (RLA) rat lines are selected for respectively rapid vs. Read More

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December 2018

Implementing the package of CDC and WHO recommended linkage services: Methods, outcomes, and costs of the Bukoba Tanzania Combination Prevention Evaluation: Peer-delivered, linkage case management program, 2014-2017.

PLoS One 2018 13;13(12):e0208919. Epub 2018 Dec 13.

National AIDS Control Program, MoHCDGEC, Dar es Salaam, Tanzania.

Although several studies have evaluated one or more linkage services to improve early enrollment in HIV care in Tanzania, none have evaluated the package of linkage services recommended by the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO). We describe the uptake of each component of the CDC/WHO recommended package of linkage services, and early enrollment in HIV care and antiretroviral therapy (ART) initiation among persons with HIV who participated in a peer-delivered, linkage case management (LCM) program implemented in Bukoba, Tanzania, October 2014 -May 2017. Of 4206 participants (88% newly HIV diagnosed), most received recommended services including counseling on the importance of early enrollment in care and ART (100%); escort by foot or car to an HIV care and treatment clinic (CTC) (83%); treatment navigation at a CTC (94%); telephone support and appointment reminders (77% among clients with cellphones); and counseling on HIV-status disclosure and partner/family testing (77%), and on barriers to care (69%). Read More

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December 2018

Review of epidemiological risk models for foot-and-mouth disease: Implications for prevention strategies with a focus on Africa.

PLoS One 2018 13;13(12):e0208296. Epub 2018 Dec 13.

Research Unit in Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR-ULiège), Fundamental and Applied Research for Animals & Health (FARAH) Centre, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium.

Foot-and-mouth disease (FMD) is a highly infectious transboundary disease that affects domestic and wild cloven-hoofed animal species. The aim of this review was to identify and critically assess some modelling techniques for FMD that are well supported by scientific evidence from the literature with a focus on their use in African countries where the disease remains enzootic. In particular, this study attempted to provide a synopsis of the relative strengths and weaknesses of these models and their relevance to FMD prevention policies. Read More

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December 2018
1 Read

Population based hospitalization burden of laboratory-confirmed hand, foot and mouth disease caused by multiple enterovirus serotypes in Southern China.

PLoS One 2018 13;13(12):e0203792. Epub 2018 Dec 13.

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Hand, foot and mouth disease (HFMD) is spread widely across Asia, and the hospitalization burden is currently not well understood. Here, we estimated serotype-specific and age-specific hospitalization rates of HFMD in Southern China.

Methods: We enrolled pediatric HFMD patients admitted to 3/3 county-level hospitals, and 3/23 township-level hospitals in Anhua county, Hunan (CN). Read More

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December 2018
2 Reads

COMPASS for Vascular Surgeons: Practical Considerations.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, University of Toronto.

Purpose Of Review: To suggest a practical approach for the application of data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial in patients with peripheral artery disease (PAD).

Recent Findings: The COMPASS trial showed that low-dose rivaroxaban 2.5 mg twice daily plus daily aspirin was superior to aspirin alone in reducing major adverse cardiovascular and cerebrovascular events, and major adverse limb events among patients with stable atherosclerotic vascular disease, including those with PAD. Read More

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December 2018

Leiomyoma of the Foot: A Case Report.

Cureus 2018 Oct 5;10(10):e3419. Epub 2018 Oct 5.

Orthopaedics, University of Alabama at Birmingham, Birmingham, USA.

Leiomyomas are benign tumors of smooth muscle origin. They are most commonly found in the uterus, but cutaneous leiomyomas may be occasionally present in the extremities and cause pain secondary to mass effect. Few studies have reported leiomyoma of the foot, and leiomyoma of the heel is particularly rare. Read More

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October 2018
3 Reads

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2.

Biosci Rep 2018 Dec 12. Epub 2018 Dec 12.

The first afflicted hospital of Xi'an JiaoTong University, Xi'an, China.

This study aimed to explore miR-125 effects on RA development to provide a potential target for RA. Briefly, rat RA model was established (Model group) by injection of Freund's Complete Adjuvant into the left hind toe. Normal rats injected with saline in the same location were set as Normal group. Read More

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December 2018
2 Reads

Contact Challenge of Cattle with Foot-and-Mouth Disease Virus Validates the Role of the Nasopharyngeal Epithelium as the Site of Primary and Persistent Infection.

mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.

Foreign Animal Disease Research Unit, USDA-ARS, Plum Island Animal Disease Center, Greenport, New York, USA

The pathogenesis of foot-and-mouth disease virus (FMDV) in cattle was investigated through early and late stages of infection by use of an optimized experimental model for controlled contact exposure. Time-limited exposure of cattle to FMDV-infected pigs led to primary FMDV infection of the nasopharyngeal mucosa in both vaccinated and nonvaccinated cattle. In nonvaccinated cattle, the infection generalized rapidly to cause clinical disease, without apparent virus amplification in the lungs prior to establishment of viremia. Read More

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December 2018
3 Reads

Malignant Melanomas of the Skin Arising on the Feet.

Klin Onkol 2018 ;31(4):289-292

Background: Cutaneous melanoma frequently develops on the lower limbs, but rarely on the feet, in people with light skin. By contrast, the feet are one of the most frequently affected sites in people with dark skin. This study assessed the prevalence and clinico-pathological findings of biopsy-proven skin melanomas that were diagnosed over 11 years. Read More

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January 2018

Corneal Subbasal Nerve Plexus Changes in Severe Diabetic Charcot Foot Deformity: A Pilot Study in Search for a DNOAP Biomarker.

J Diabetes Res 2018 4;2018:5910639. Epub 2018 Nov 4.

Department of Ophthalmology, Rostock University Medical Center, Doberaner Straße 140, 18057 Rostock, Germany.

Introduction: Diabetic neuroosteoarthropathy (DNOAP) early symptoms are unspecific, mimicking general infectious symptoms and rendering a diagnosis challenging. Consequently, unfavourable outcomes occur frequently, with recurrent foot ulceration, infectious complications, and eventually amputation. Corneal confocal microscopy (CCM) of the subbasal nerve plexus (SNP) is used to detect early peripheral neuropathy in diabetic patients without diabetic retinopathy. Read More

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November 2018

Radiographic Identification of Osseous Cyst- Like Lesions in the Distal Phalanx in 22 Lame Thoroughbred Horses Managed Conservatively and Their Racing Performance.

Front Vet Sci 2018 22;5:286. Epub 2018 Nov 22.

Division of Clinical Radiology, Department of Clinical Veterinary Science, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

To investigate the racing performance of Thoroughbred horses with osseous cyst-like lesions (OCLLs) in the distal phalanx causing lameness and treated conservatively. To assess horses' ability to race and perform after radiographic identification of OCLL in the distal phalanx of Thoroughbred horses with lameness at the time of detection and undergoing conservative treatment. Retrospective case control study. Read More

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November 2018

Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response.

Front Immunol 2018 21;9:2631. Epub 2018 Nov 21.

Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute (IVRI), Bareilly, India.

In this study, the miRNAome and proteome of virulent Peste des petits ruminants virus (PPRV) infected goat peripheral blood mononuclear cells (PBMCs) were analyzed. The identified differentially expressed miRNAs (DEmiRNAs) were found to govern genes that modulate immune response based on the proteome data. The top 10 significantly enriched immune response processes were found to be governed by 98 genes. Read More

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November 2018

Perturbation-Based Balance Training to Improve Step Quality in the Chronic Phase After Stroke: A Proof-of-Concept Study.

Front Neurol 2018 22;9:980. Epub 2018 Nov 22.

Department of Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.

People with stroke often have impaired stepping responses following balance perturbations, which increases their risk of falling. Computer-controlled movable platforms are promising tools for delivering perturbation-based balance training under safe and standardized circumstances. This proof-of-concept study aimed to identify whether a 5-week perturbation-based balance training program on a movable platform improves reactive step quality in people with chronic stroke. Read More

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November 2018

Maneuvering and stabilization control of a bipedal robot with a universal-spatial robotic tail.

Bioinspir Biomim 2018 Nov 16. Epub 2018 Nov 16.

Mechanical Engineering, Virginia Tech, 635 Prices Fork Road - MC 0238, Suite 465, Blacksburg, Virginia, 24061, UNITED STATES.

This paper analyzes control methodologies to implement maneuvering and stabilization behaviors in a bipedal robot using a bioinspired robotic tail. Looking to nature, numerous animals augment their legs' functionality using a tail to assist with both maneuvering and stabilization; looking to the robotics literature, previous research primarily focuses on single-mass, pendulum-like tails designed to perform a specific task. The overarching goal of this research is to study how bioinspired tail designs may be used in conjunction with low-complexity leg designs to achieve high-performance behaviors. Read More

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November 2018

Real-time gait event detection in a real-world environment using a laser-ranging sensor and gyroscope fusion method.

Physiol Meas 2018 Oct 12. Epub 2018 Oct 12.

College of Biomedical Engineering and Instrument Science, Zhejiang University, Zhejiang Province ZheDa road 38#, Hangzhou, Zhejiang, 310027, CHINA.

Objective: Wearable gait event detection (GED) techniques have great potential for clinical applications by aiding the rehabilitation of individuals in their daily living environment. Unlike previous wearable GED techniques, which have been proposed for offline detection or laboratory settings, we aimed to develop a real-time GED system adapted for utilization in the daily living environment. Approach: This study presents a novel GED system in which foot clearance and sagittal angular velocity were incorporated to realize real-time GED in a real-world environment. Read More

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October 2018

Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71.

Viral Immunol 2018 Dec 6. Epub 2018 Dec 6.

Department of Laboratory Medicine, School of Medicine, Shaoxing University , Shaoxing, P.R. China .

Enterovirus 71 (EV-A71) has attracted widespread attention in the past decade because of its higher neurotropicity in addition to causing hand-foot-and-mouth disease (HFMD). Mapping epitopes of viral proteins may promote our understanding of antiviral humoral immunity, and is useful for clinical application. In this study, the linear B cell epitopes within nonstructural proteins of EV-A71 were identified using bioinformatics methods combined with peptide enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018
1.636 Impact Factor

Skin adverse events in recently approved targeted therapies in solid malignancies.

Future Oncol 2018 Dec 7. Epub 2018 Dec 7.

Unité de Génétique Médicale, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Targeted anticancer therapies are an important weapon in the fight against cancer. Targeted therapies interfere with specific molecules necessary for tumor growth and cancer progression. They are divided mainly to either monoclonal antibodies or small molecules inhibitors. Read More

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December 2018
1 Read

Descriptions of two new acanthocephalans (Rhadinorhynchidae) from marine fish off the Pacific coast of Vietnam.

Syst Parasitol 2018 Dec 6. Epub 2018 Dec 6.

Department of Parasitology, Institute of Ecology and Biological Resources (IEBR), Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.

Two rhadinorhynchid acanthocephalans are described from marine fishes off the Pacific coast of Vietnam. Sclerocollum neorubrimaris n. sp. Read More

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December 2018

Multicenter retrospective analysis of the safety and efficacy of regorafenib after progression on sorafenib in Korean patients with hepatocellular carcinoma.

Invest New Drugs 2018 Dec 7. Epub 2018 Dec 7.

Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background The pivotal RESORCE trial showed that regorafenib was effective as second-line therapy for patients with advanced HCC who progressed on first-line sorafenib. Real-world data are needed to assess clinical outcomes and adverse events in the setting of daily practice. Methods Between April 2017 and August 2017, the Named Patient Program (NPP) was activated to provide controlled, pre-approval access of regorafenib in Korea. Read More

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December 2018

Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial.

Lancet Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. Electronic address:

Background: Glioblastoma is a highly vascularised tumour and there are few treatment options after disease recurrence. Regorafenib is an oral multikinase inhibitor of angiogenic, stromal, and oncogenic receptor tyrosine kinases. We aimed to assess the efficacy and safety of regorafenib in the treatment of recurrent glioblastoma. Read More

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December 2018

Reliability of the talocalcaneal angle for the evaluation of hindfoot alignment.

Rev Esp Cir Ortop Traumatol 2018 Dec 3. Epub 2018 Dec 3.

Departamento de Ortopedia y Traumatología Infantil, Sanatorio Allende, Córdoba, Argentina.

Introduction: Recent studies suggest that hindfoot deformity should be considered in the surgical treatment of tarsal coalitions. Many authors have used the angle between the talus and the calcaneus (TCA) for decision-making. However, its reliability has not been demonstrated and the measurement technique has not been standardized. Read More

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December 2018

Frequency-dependent contributions of sagittal-plane foot force to upright human standing.

J Biomech 2018 Nov 29. Epub 2018 Nov 29.

Department of Mechanical Engineering, University of Wisconsin-Madison, United States; Department of Kinesiology, University of Wisconsin-Madison, United States; Department of Biomedical Engineering, University of Wisconsin-Madison, United States. Electronic address:

Quiet standing is a mechanically unstable postural objective that humans typically perform with ease. Control of upright posture requires stabilization of both translational and rotational degrees-of-freedom that is accomplished by neuro-muscular coordination. This coordination produces a force at the ground-foot interface (F) that is quantified by magnitude, direction (θ), and point of application (center-of-pressure, CP). Read More

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November 2018