10,237 results match your criteria Food and Chemical Toxicology [Journal]


Aloin reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB.

Food Chem Toxicol 2019 Feb 13;126:67-71. Epub 2019 Feb 13.

College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Here, we aimed to determine the effects of aloin on heme oxygenase-1 (HO-1) induction and on the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX) 2 in lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs). To the end, aloin was tested whether aloin reduces iNOS protein expression and inflammatory markers (interleukin (IL)-1β and tumor necrosis factor (TNF)-α) in LPS-treated mice lung tissue. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.025DOI Listing
February 2019

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis.

Food Chem Toxicol 2019 Feb 12;126:41-55. Epub 2019 Feb 12.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, India. Electronic address:

Arsenic contaminated drinking water consumption is a serious health issue around the world. Chronic inorganic arsenic exposure has been associated with respiratory dysfunctions. It exerts various detrimental effects, disrupting normal cellular homeostasis and turning on severe pulmonary complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193007
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http://dx.doi.org/10.1016/j.fct.2019.02.022DOI Listing
February 2019
1 Read

A six-month systems toxicology inhalation/cessation study in ApoE mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address:

Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling to quit, to lessen the smoking-related health risks. In this study, the ApoE mouse model was used to investigate the impact of cigarette smoke (CS) from the reference cigarette 3R4F, or aerosol from two potential MRTPs based on the heat-not-burn principle, carbon-heated tobacco product 1. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.008DOI Listing
February 2019

Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, 90741, Taiwan. Electronic address:

Erianin is the major bibenzyl compound found in Dendrobium chrysotoxum Lindl. The current study was designed to investigate the protective effects of erianin on high glucose-induced injury in cultured renal tubular epithelial cells (NRK-52E cells) and determine the possible mechanisms for its effects. NRK-52E cells were pretreated with erianin (5, 10, 25 or 50 nmol/L) for 1 h followed by further exposure to high glucose (30 mmol/L, HG) for 48 h. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.021DOI Listing
February 2019

Crocus sativus by-products as sources of bioactive extracts: Pharmacological and toxicological focus on anthers.

Food Chem Toxicol 2019 Feb 11;126:7-14. Epub 2019 Feb 11.

Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.

Multiple studies revealed the potential application of high quality saffron byproducts as cheap sources of bioactive compounds endowed with antioxidant activity. In the present study, we analyzed the total fatty acids of the anthers, and explored the pharmacological and toxicological potential of anthers, by evaluating genotoxic and protective effects in multiple cell lines, brine shrimps and isolated rat tissues. The phytochemical analyses showed that anthers are rich in long chain fatty acids most of which are unsaturated (80. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.040DOI Listing
February 2019

Probiotic Bacillus subtilis CW14 reduces disruption of the epithelial barrier and toxicity of ochratoxin A to Caco-2 cells.

Food Chem Toxicol 2019 Feb 11;126:25-33. Epub 2019 Feb 11.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, China; Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China. Electronic address:

The multiple toxic effects of ochratoxin A (OTA) are a threat for human and animal. This study aimed to examine whether B. subtilis CW14 protected against OTA-induced barrier disruption and cell damage to Caco-2 cells. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.009DOI Listing
February 2019

Scandenolone from Cudrania tricuspidata fruit extract suppresses the viability of breast cancer cells (MCF-7) in vitro and in vivo.

Food Chem Toxicol 2019 Feb 10;126:56-66. Epub 2019 Feb 10.

Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, PR China. Electronic address:

Scandenolone, an isoflavone, has shown anti-cancer potential. In this study, we extracted scandenolone from Cudrania tricuspidata fruit and evaluated its anti-breast cancer effects as well as toxicity in cell and animal models. In cell model, scandenolone suppressed the breast cancer MCF-7 cells viability, ceased mitotic cell cycle, decreased mitochondrial membrane potential, up-regulated cleaved caspase-3 and promoted the phosphorylation of p53. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193007
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http://dx.doi.org/10.1016/j.fct.2019.02.020DOI Listing
February 2019
17 Reads
2.895 Impact Factor

Health risk assessment of acrylamide in bread in Iran using LC-MS/MS.

Food Chem Toxicol 2019 Feb 9. Epub 2019 Feb 9.

Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Acrylamide is a chemical, often present in bread, legally classified as carcinogen, mutagen and reproductive toxicant. Since bread is consumed both world-wide and in Iran, determination of acrylamide in different types of breads is of high interest. In the present study, acrylamide was monitored in 56 Sangak and 30 industrial bread samples collected from Tehran and Shiraz, using LC-MS/MS (LOQ = 1 ng/g). Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.019DOI Listing
February 2019
1 Read

A probabilistic approach for risk-benefit assessment of food substitutions: A case study on substituting meat by fish.

Food Chem Toxicol 2019 Feb 8;126:79-96. Epub 2019 Feb 8.

Biometris, Wageningen University & Research (WUR), Droevendaalsesteeg 1, 6708 PB, Wageningen, the Netherlands.

Accounting for substitution of foods is inevitable when evaluating health impact of dietary changes. But substitution behavior and the associated health impact may vary between individuals. We therefore propose the use of probabilistic methods to model substitution and assess health impact distributions in risk-benefit assessment (RBA) of foods. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.018DOI Listing
February 2019

Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats.

Food Chem Toxicol 2019 Feb 7;126:34-40. Epub 2019 Feb 7.

Department of Biochemistry, University of Allahabad, Allahabad, 211002, India. Electronic address:

Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.032DOI Listing
February 2019
2 Reads

Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity.

Food Chem Toxicol 2019 Feb 7;125:549-561. Epub 2019 Feb 7.

UMRi CNRS 7266 LIENSs, Université de La Rochelle, 17042 La Rochelle, France. Electronic address:

Cutaneous melanoma has a high capacity to metastasize and significant resistance to conventional therapeutic protocols, which makes its treatment difficult. The combination of conventional drugs with cytostatic molecules of low toxicity has been shown to be an interesting alternative for sensitization of tumor cells to chemotherapy. In this study, we evaluated the effect of bixin, an abundant apocarotenoid present in Bixa orellana, on the sensitization of human melanoma cells (A2058) to dacarbazine treatment, an anticancer agent clinically used for the therapy of metastatic melanoma. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.013DOI Listing
February 2019
2 Reads

Serum Bisphenol A concentrations in men with idiopathic infertility.

Food Chem Toxicol 2019 Feb 7;125:562-565. Epub 2019 Feb 7.

Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece.

Background: Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility.

Aim: To investigate serum BPA concentrations in infertile men according to infertility cause. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.016DOI Listing
February 2019

Manganese induced ROS and AChE variants alteration leads to SN56 basal forebrain cholinergic neuronal loss after acute and long-term treatment.

Food Chem Toxicol 2019 Feb 7;125:583-594. Epub 2019 Feb 7.

Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040, Madrid, Spain. Electronic address:

Manganese (Mn) induces cognitive disorders and basal forebrain (BF) cholinergic neuronal loss, involved on learning and memory regulation, which could be the cause of such cognitive disorders. However, the mechanisms through which it induces these effects are unknown. We hypothesized that Mn could induce BF cholinergic neuronal loss through oxidative stress generation, cholinergic transmission and AChE variants alteration that could explain Mn cognitive disorders. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.012DOI Listing
February 2019

Identification of narciclasine from Lycoris radiata (L'Her.) Herb. and its inhibitory effect on LPS-induced inflammatory responses in macrophages.

Food Chem Toxicol 2019 Feb 7;125:605-613. Epub 2019 Feb 7.

College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China. Electronic address:

Lycoris radiata (L'Her.) Herb. (L. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.003DOI Listing
February 2019
2 Reads

Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte.

Food Chem Toxicol 2019 Feb 6;125:595-604. Epub 2019 Feb 6.

Department of Food Science, University of Massachusetts, Amherst, USA. Electronic address:

Recent studies have reported the positive association between exposure to insecticides and increased risk of obesity and type 2 diabetes, which are closely associated with non-alcoholic fatty liver disease (NAFLD). However, it is not known if insecticide exposure can contribute to NAFLD. Thus, the goal of the current study was to determine if insecticide exposures can exacerbate the physiological conditions of NAFLD by modulating hepatic lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.005DOI Listing
February 2019
1 Read

Limonin attenuates the stemness of cervical carcinoma cells by promoting YAP nuclear-cytoplasmic translocation.

Food Chem Toxicol 2019 Feb 7;125:621-628. Epub 2019 Feb 7.

Department of Obstetrics, Henan Province Hospital of Traditional Chinese Medicine, No.6 Dongfeng Road, Jinshui District, Zhengzhou, 450002, China. Electronic address:

This work aimed to investigate the role and related mechanism of limonin in regulating the stemness of cervical carcinoma (CC) cells. In the present study, we constructed adriamycin-resistant CC cells and found that they exhibited greater stemness than parental cells. Additionally, limonin attenuated the stemness of CC cells that were resistant or sensitive to adriamycin, as evidenced by the decreases in spheroid formation capacity, stemness markers expression and ALDH1 activity, whereas limonin did not affect the viability of normal cervical epithelial cells. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.011DOI Listing
February 2019
1 Read

Isorhamnetin and its new derivatives isolated from sea buckthorn berries prevent HO/Fe - Induced oxidative stress and changes in hemostasis.

Food Chem Toxicol 2019 Feb 6;125:614-620. Epub 2019 Feb 6.

Department of Biochemistry, Institute of Soil Science and Plant Cultivation, State Research Institute, 24-100, Puławy, Poland.

The objective of this study is to investigate the biological effects of phenolic compounds extracted from the sea buckthorn berries on oxidative stress and hemostasis. The sea buckthorn (Elaeagnus rhamnoides (L.) A. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.014DOI Listing
February 2019

Development of morin/hydroxypropyl-β-cyclodextrin inclusion complex: Enhancement of bioavailability, antihyperalgesic and anti-inflammatory effects.

Food Chem Toxicol 2019 Feb 6;126:15-24. Epub 2019 Feb 6.

Department of Pharmacy, Federal University of Sergipe, Elze, São Cristóvão, SE, 49100-000, Brazil. Electronic address:

Morin is a flavonoid has been reported with several pharmacological effects such as, antioxidant, anti-inflammatory, anticancer, antidiabetic, etc. However, morin has low solubility in water, which decreases the bioavailability and limits its clinical application. In this way, to improve the pharmaceutical properties, morin was complexed in hydroxypropyl-β-cyclodextrin (HP-β-CD) and its oral bioavailability and anti-inflammatory effects were evaluated. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.038DOI Listing
February 2019
3 Reads

Equivalence limit scaled differences for untargeted safety assessments: Comparative analyses to guard against unintended effects on the environment or human health of genetically modified maize.

Food Chem Toxicol 2019 Feb 5;125:540-548. Epub 2019 Feb 5.

Slovak Medical University (SZU), Faculty of Medicine, Limbová 12, 83303, Bratislava, Slovakia.

Safety assessments guard against unintended effects for human health and the environment. When new products are compared with accepted reference products by broad arrays of measurements, statistical analyses are usually summarised by significance tests or confidence intervals per endpoint. The traditional approach is to test for statistical significance of differences. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.007DOI Listing
February 2019
1 Read

Modulation of LPS-induced nitric oxide production in intestinal cells by hydroxytyrosol and tyrosol metabolites: Insight into the mechanism of action.

Food Chem Toxicol 2019 Feb 5;125:520-527. Epub 2019 Feb 5.

Department of Biomedical Sciences, Unit of Experimental Pathology, University of Cagliari, Cittadella Universitaria SS 554, 09042, Monserrato, CA, Italy. Electronic address:

At intestinal level, after acute or chronic exposure to iNOS-derived NO, a toxic mechanism of action leads to inflammation and degenerative diseases. The aim of this study was to investigate the effect of glucuronide and sulfate metabolites of the extra virgin olive oil phenols tyrosol (Tyr) and hydroxytyrosol (HT), in comparison with their parent compounds, on the release of NO following exposure to a pro-inflammatory stimulus, the bacterial lipopolysaccharide (LPS). Human colon adenocarcinoma cells (Caco-2), differentiated as normal enterocytes, were treated with pathological concentrations of LPS, in order to stimulate iNOS pathway, which involves NF-ĸB activation through IĸBα phosphorylation and subsequent degradation induced by Akt or MAPKs. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.039DOI Listing
February 2019
2 Reads

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Feb 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
February 2019
1 Read

Occurrence and bioaccessibility of mercury in commercial rice samples in Montreal (Canada).

Food Chem Toxicol 2019 Feb 5;126:72-78. Epub 2019 Feb 5.

Department of Food Science and Agricultural Chemistry, McGill University, Canada. Electronic address:

The objective of this study was to increase the understanding of mercury exposure via rice commonly consumed in a major North American city. Rice samples were collected from Montreal markets (n = 89) between 2016 and 2017 and analyzed for total mercury (THg) content. THg content ranged from 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193005
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http://dx.doi.org/10.1016/j.fct.2019.02.006DOI Listing
February 2019
5 Reads

Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-κB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis.

Food Chem Toxicol 2019 Feb 6;125:503-519. Epub 2019 Feb 6.

Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:

The present investigation has been undertaken to reveal the protective mechanism of polyphenolics extract of whole wheat grains (WWGPE), ferulic acid and apigenin against doxorubicin (Dox)-induced cardio-toxicity. WWGPE, apigenin, and ferulic acid exhibited concentration dependent cyto-protective effect against Dox (1 μM) in rat cardiomyocytes. Dox treatment significantly (p < 0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.034DOI Listing
February 2019

Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies.

Food Chem Toxicol 2019 Feb 5;125:494-502. Epub 2019 Feb 5.

The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. The objective of this review is to provide a systematic evaluation of the evidence and a meta-analysis of data from previously published researches on the antidiabetic action of quercetin. A comprehensive literature search was conducted between July 2018 and August 2018 on PubMed, EMBASE, Web of Sciences and Scopus databases. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.037DOI Listing
February 2019

Microbial metabolites of proanthocyanidins reduce chemical carcinogen-induced DNA damage in human lung epithelial and fetal hepatic cells in vitro.

Food Chem Toxicol 2019 Feb 5;125:479-493. Epub 2019 Feb 5.

Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, Canada; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Seven selected microbial metabolites of proanthocyanidins (MMP), 3-phenylpropionic, 4-hydroxyphenyl acetic, 3-(4-hydroxyphenyl) propionic, p-coumaric, benzoic acid, pyrogallol (PG), and pyrocatechol (PC) were evaluated for their ability to reduce chemical carcinogen-induced toxicity in human lung epithelial cells (BEAS-2B) and human fetal hepatic cells (WRL-68). Cells pre-treated with MMP were exposed to a known chemical carcinogen, 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-butanone (NNKOAc) to assess MMP-mediated cytoprotection and reduction of DNA damage. PG in BEAS-2B and PC in WRL-68 cells mitigated the NNKOAc-induced cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.010DOI Listing
February 2019

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment.

Food Chem Toxicol 2019 Feb 2;125:467-478. Epub 2019 Feb 2.

Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.

The presence and accompanying risks of methyleugenol and eugenol in herbal beverages available on the Indonesian market were evaluated. Methyleugenol was detected in 49 out of 114 samples, at levels amounting to 2.6-443. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.001DOI Listing
February 2019

3-NOP: ADME studies in rats and ruminating animals.

Food Chem Toxicol 2019 Feb 2;125:528-539. Epub 2019 Feb 2.

DSM Nutritional Products AG, Wurmisweg 576, 4303, Kaiseraugst, Switzerland.

3-NOP (3-nitrooxypropanol) reduces enteric methane formation in ruminants. A series of ADME studies in rats, lactating goats and beef cattle was performed. 3-NOP was entirely absorbed from the GIT of rats: approximately 75% of the administered 3-NOP was eliminated as carbon dioxide via exhalation and approximately 20% were excreted via urine. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.002DOI Listing
February 2019

Cytotoxicity against fish and mammalian cell lines and endocrine activity of the mycotoxins beauvericin, deoxynivalenol and ochratoxin-A.

Food Chem Toxicol 2019 Feb 1. Epub 2019 Feb 1.

Department of Environment, National Institute for Agricultural and Food Research and Technology (INIA), Carretera de la Coruña km 7, 28040, Madrid, Spain. Electronic address:

The toxicity of mycotoxins is well recognized in mammals, but their effects on fish have received less attention. Moreover, in the last years several studies have reported that some mycotoxins may act as endocrine disruptors. The aim of this study was to determine the cytotoxic effects and endocrine activities of three mycotoxins, beauvericin, deoxynivalenol and ochratoxin-A. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.036DOI Listing
February 2019

RIFM fragrance ingredient safety assessment, 2-ethyl-5-methoxybicyclo[2.2.1]heptane, CAS registry number 122795-41-9.

Food Chem Toxicol 2019 Feb 1. Epub 2019 Feb 1.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) (CAS # 211299-54-6) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) show that it is not genotoxic, and that there are no safety concerns for skin sensitization under the current, declared levels of use. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.031DOI Listing
February 2019

Multiple pharmacognostic characterization on hemp commercial cultivars: Focus on inflorescence water extract activity.

Food Chem Toxicol 2019 Jan 31;125:452-461. Epub 2019 Jan 31.

Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Chieti, 66100, Italy.

One of the most promising economic perspectives of hemp production chain is female inflorescence valorization, despite there being actually no chemical composition or biological data from water fraction. In this context, the focus of this study is the evaluation of protective effects related to hemp water flower extracts from four commercial cultivars (Futura 75, Kc virtus, Carmagnola Cs and Villanova). We evaluated the phytochemical profile through validated spectrophotometric and HPLC methods. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.035DOI Listing
January 2019

Zinc citrate incorporation with whey protein nanoparticles alleviate the oxidative stress complication and modulate gene expression in the liver of rats.

Food Chem Toxicol 2019 Jan 31;125:439-451. Epub 2019 Jan 31.

Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo, Egypt. Electronic address:

This study aimed to evaluate the hepatoprotective effect of whey protein nanoparticles (WP-NPs) coated Zinc citrate (Zn) against oxidative stress complications and disturbances in gene expression in rats treated with CCl. WP-NPs were used to coat Zn at three levels and amino acids content was determined in WP-NPs and the fabrications. Seven groups of male albino rats included the control group, CCl-treated group (0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.026DOI Listing
January 2019

Importance of antibiotic residues in animal food.

Food Chem Toxicol 2019 Jan 30;125:462-466. Epub 2019 Jan 30.

Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, 06100, Ankara, Turkey.

Veterinary medicines, especially antibiotics, are among the most important components related to animal feed production. Generally, the main use of antibiotics in animals is for the treatment and prevention of diseases and growth promotion. Antibiotic usage in animals may result antibiotic residues in foodstuffs such as milk, egg and meat. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.033DOI Listing
January 2019
1 Read

Victor Feron, A life dedicated to toxicology and toxicologic pathology.

Food Chem Toxicol 2019 Jan 29;125:438. Epub 2019 Jan 29.

Professor of Environmental Medicine and Urology, Pathology Department, University of Illinois, 909 South Wolcott Ave, Chicago, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.01.006DOI Listing
January 2019

PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells.

Food Chem Toxicol 2019 Jan 29;125:430-437. Epub 2019 Jan 29.

Department of Nutrition, China Medical University, Taichung, Taiwan. Electronic address:

Impairment in mitophagy contributes to the pathology of Parkinson's disease. This study investigated whether Phosphatase and tensin homologue (PTEN)-induced kinase 1 (PINK1)/parkin-mediated mitophagy is linked to the protective effect of carnosic acid (CA) from rosemary. Treatment of SH-SY5Y cells with 6-hydroxydopamine (6-OHDA) disrupted the mitochondrial membrane potential, inhibited voltage-dependent anion channel 1 (VDAC1) protein, and induced cytosolic cytochrome c, but CA pretreatment reversed these findings. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.027DOI Listing
January 2019
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Comparative antitumor and anti-inflammatory effects of flavonoids, saponins, polysaccharides, essential oil, coumarin and alkaloids from Cirsium japonicum DC.

Food Chem Toxicol 2019 Jan 28;125:422-429. Epub 2019 Jan 28.

The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. Electronic address:

Cirsium japonicum DC (Asteraceae) is a perennial thistle widely distributed in Asia, it is also consumed as functional food and herb in China. To analyze the health effects of C. japonicum, flavonoids, saponins, polysaccharides, essential oil, coumarin and alkaloids were extracted from C. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.020DOI Listing
January 2019

The effects of pinoresinol on cholinergic dysfunction-induced memory impairments and synaptic plasticity in mice.

Food Chem Toxicol 2019 Jan 24;125:376-382. Epub 2019 Jan 24.

Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan, 49315, Republic of Korea; Institute of Convergence Bio-Health, Dong-A University, Busan, 49315, Republic of Korea. Electronic address:

Dementia is a category of brain diseases that cause a decrease in cognitive functions. Alzheimer's disease (AD) is the most frequently mentioned neurodegenerative disease showing dementia. Although many useful drugs for dementia were developed, we still need better and safer drugs. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.017DOI Listing
January 2019
2 Reads

Sensitivity analysis to derive a food consumption point estimate for deterministic food allergy risk assessment.

Food Chem Toxicol 2019 Jan 25;125:413-421. Epub 2019 Jan 25.

The Netherlands Organisation for Applied Scientific Research TNO, Zeist, the Netherlands.

One of the input parameters in food allergy risk assessment is the amount of a given food consumed at an eating occasion. There is no consensus on how to use food consumption data when assessing the risk from unintended allergen presence in food products. A sensitivity analysis was performed to establish the optimal food consumption estimate for a deterministic food allergy risk assessment. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.025DOI Listing
January 2019
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Emerging role of plumbagin: Cytotoxic potential and pharmaceutical relevance towards cancer therapy.

Food Chem Toxicol 2019 Jan 24;125:566-582. Epub 2019 Jan 24.

Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, 769008, Sundergarh, Odisha, India. Electronic address:

Plumbagin is a naphthoquinone derived yellow crystalline phytochemical. Plumbagin has a wide range of biological effects including cytotoxicity against cancer cells both in vitro and in vivo. Due to the pleiotropic nature of plumbagin, it shows the anticancer effect by targeting several molecular mechanisms including apoptosis and autophagic pathways, cell cycle arrest, anti-angiogenic pathways, anti-invasion and anti-metastasis pathways. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193002
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http://dx.doi.org/10.1016/j.fct.2019.01.018DOI Listing
January 2019
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Inhibitory effects of compounds isolated from Lepechinia meyenii on tyrosinase.

Food Chem Toxicol 2019 Jan 23;125:383-391. Epub 2019 Jan 23.

Fine Chemical and Natural Products Laboratory, School of Chemistry, IRNASUS-CONICET, Catholic University of Córdoba, Avda. Armada Argentina 3555, X5016DHK, Córdoba, Argentina. Electronic address:

To contribute enzymatic browning inhibitors to the food industry and also extend knowledge about the phytochemical profile of the anti-tyrosinase plant Lepechinia meyenii, its ethanol extract was subjected to bioguided fractionation. Three hydroxycinnamic acids, p-coumaric acid (1), caffeic acid (2) and rosmarinic acid (3), were isolated as mainly responsible for its activity. Compounds 1, 2 and 3 showed themselves highly effective for inhibiting tyrosinase with IC values of 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193002
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http://dx.doi.org/10.1016/j.fct.2019.01.019DOI Listing
January 2019
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Occurrence of environmental pollutants in foodstuffs: A review of organic vs. conventional food.

Food Chem Toxicol 2019 Jan 22;125:370-375. Epub 2019 Jan 22.

Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Catalonia, Spain.

In recent years, there is an increasing trend to consume organic foods instead of the conventional foodstuffs. This tendency is mainly due to the concern raised by the potential adverse health effects derived from the intake of pesticides, fertilizers, hormones and antibiotics, which are widely used in regular food production. Although organic label forbids the use of these products, environmental contamination is likely to occur in both, conventional and organic foodstuffs. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.021DOI Listing
January 2019

Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein.

Food Chem Toxicol 2019 Jan 21;125:403-412. Epub 2019 Jan 21.

Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece. Electronic address:

Olive oil is widely accepted as a superior edible oil. Great attention has been given lately to olive oil polyphenols which are linked to significant health beneficial effects. Towards a survey of Greek olive oil focusing on polyphenols, representative extra virgin olive oils (EVOOs) from the main producing areas of the country and the same harvesting period have been collected and analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193001
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http://dx.doi.org/10.1016/j.fct.2019.01.016DOI Listing
January 2019
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Applications of in silico methods to analyze the toxicity and estrogen receptor-mediated properties of plant-derived phytochemicals.

Food Chem Toxicol 2019 Jan 21;125:361-369. Epub 2019 Jan 21.

Department of Zoology, Sri Venkateswara University, Tirupati, 517502, India. Electronic address:

A myriad of phytochemicals may have potential to lead toxicity and endocrine disruption effects by interfering with nuclear hormone receptors. In this examination, the toxicity and estrogen receptor-binding abilities of a set of 2826 phytochemicals were evaluated. The endpoints mutagenicity, carcinogenicity (both CAESAR and ISS models), developmental toxicity, skin sensitization and estrogen receptor relative binding affinity (ER_RBA) were studied using the VEGA QSAR modeling package. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.033DOI Listing
January 2019
2 Reads
2.895 Impact Factor

Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2.

Food Chem Toxicol 2019 Jan 22;125:354-360. Epub 2019 Jan 22.

Department of Oncology, Korea University Guro Hospital, 148 Gruodong-gil, Guro-gu, Seoul, 08308, Republic of Korea; Graduate School of Medicine, Korea University College of Medicine, Seoul, 08308, Republic of Korea. Electronic address:

Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.023DOI Listing
January 2019
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Insights into cellular metabolic pathways of the combined toxicity responses of Caco-2 cells exposed to deoxynivalenol, zearalenone and Aflatoxin B.

Food Chem Toxicol 2019 Jan 19. Epub 2019 Jan 19.

State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, 214122, PR China. Electronic address:

Metabolic profiling in Caco-2 cells was studied for the combined toxic effects of deoxynivalenol (DON), zearalenone (ZEN), and Aflatoxin B (AFB) through untargeted GC-MS. The GC-MS spectra of Caco-2 cells treated with individual 6.7 μM DON, 20 μM ZEN, 20 μM AFB and the combined DON + AFB (6. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.052DOI Listing
January 2019
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Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine.

Food Chem Toxicol 2019 Jan 18;125:392-402. Epub 2019 Jan 18.

Department of Occupational and Environment Health, Dalian Medical University, 9 Lvshun South Road, Dalian, 116044, PR China; Global Health Research Center, Dalian Medical University, 9 Lvshun South Road, Dalian, 116044, PR China. Electronic address:

Low-level inorganic arsenic (iAs) in drinking water is a risk factor for β cells dysfunction. Taurine (Tau) is a kind of semi-essential β amino acid, and beneficial for β cell function. However, the effects of Tau on arsenic trioxide (AsO) induced β cells dysfunction and related mechanisms are still uncertain. Read More

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http://dx.doi.org/10.1016/j.fct.2019.01.015DOI Listing
January 2019
1 Read