10,134 results match your criteria Food and Chemical Toxicology [Journal]


Presence of aiiA homologue genes encoding for N-Acyl homoserine lactone-degrading enzyme in aflatoxin B-decontaminating Bacillus strains with potential use as feed additives.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Fisico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta N 36 Km 601, (5800) Río Cuarto, Córdoba, Argentina; Member of Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

Microbial degradation of aflatoxins (AFs) is an alternative to the use of mycotoxin binders. The lactone ring is a possible target for microbial enzymes and its cleavage reduces AFs toxicity. The aim of this study was to isolate and identify Bacillus strains able to degrade AFB to less toxic metabolites and to identify aiiA genes encoding for N-acyl-homoserine lactone (AHL) lactonase to possibly correlate detoxification with the production of this enzyme. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.016DOI Listing
December 2018

Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

University of Reading, Department of Food and Nutritional Sciences, PO Box 226, Whiteknights, Reading, RG6 6AP, UK.

Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes in the gut microbiota and their corresponding sequelae, and to determine if consuming LNCS (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183087
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http://dx.doi.org/10.1016/j.fct.2018.12.005DOI Listing
December 2018
1 Read

Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech Building, Biocant Park, 3060-197, Cantanhede, Portugal. Electronic address:

Dose-dependent and cumulative cardiotoxicity associated with doxorubicin (DOX) is the main limitation of anticancer therapy. Pediatric cancer survivors are particularly vulnerable, and no effective prevention measures are available. The aim of the present study was to investigate the persistent effects of nanomolar DOX concentrations and determine whether a pretreatment would induce mitochondrial adaptations in H9c2 cardiomyoblasts. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.017DOI Listing
December 2018

Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.

Food Chem Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria s/n, Ciudad de México, 04650, Mexico. Electronic address:

Rheumatoid arthritis (RA) is an autoimmune disease that causes physical disability in people worldwide. Despite progress made in RA treatment in the past decade, new drugs with high efficacy but few long-term adverse effects are still needed. This study focused on evaluating the therapeutic potential of α-mangostin on established collagen-induced arthritis (CIA) in DBA/1J mice. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.018DOI Listing
December 2018

Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency.

Food Chem Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 93771, USA. Electronic address:

Evaluating the biological significance of human-relevant exposures to environmental estrogens involves assessing the individual and total estrogenicity of endogenous and exogenous estrogens found in serum, for example from biomonitoring studies. We developed a method for this assessment by integrating approaches for (i) measuring total hormone concentrations by mass spectrometry (Fleck et al., 2017), (ii) calculating hormone bioavailable concentrations in serum and, (iii) solving multiple equilibria between estrogenic ligands and receptors, and (iv) quantitatively describing key elements of estrogen potency. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.013DOI Listing
December 2018

Skim milk powder with high content of Maillard reaction products affect weight gain, organ development and intestinal inflammation in early life in rats.

Food Chem Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Sweden; Skane University Hospital, Department of Endocrinology, Lund, Sweden. Electronic address:

Background: The intestinal tract is important for development of immune tolerance and disturbances are suggested to trigger autoimmune disorders. The aim of this study was to explore the effect of Maillard products in skim milk powder obtained after long storage, compared to fresh skim milk powder.

Methods: Young rats were weaned onto a diet based on skim milk powder with high concentration of Maillard products (HM-SM, n = 18) or low (C-SM, n = 18) for one week or four weeks. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.015DOI Listing
December 2018
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Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin.

Food Chem Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Departamento de Bioquímica-Instituto de Investigaciones Biomédicas "Alberto Sols", Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Madrid, Spain. Electronic address:

Resveratrol is a polyphenol with chemopreventive properties against prostate cancer; however, the mechanisms underlying its actions are not completely understood. Previously, we demonstrated that DUSP1 induces apoptosis in prostate cancer cells; therefore in the present study we investigated the role of this phosphatase on resveratrol effects. Moreover, we analysed the efficiency of combined treatment of resveratrol and the chemotherapeutic drug cisplatin on cellular viability and apoptosis and its relation with DUSP1 in prostate cancer cells. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.014DOI Listing
December 2018
2 Reads

Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address:

Phthalates are being suggested to be associated with altered thyroid function and proliferative changes, but detailed mechanisms remain unclear. Here, we examined the effects of di-(2-ethylhexyl) phthalate (DEHP) on DNA damage and proliferation in thyroid using thyroid carcinoma cell line, 8505C, in vitro and the rats orally treated with DEHP at 0, 0.3, 3, 30 and 150 mg/kg for 90 days from post-natal day 9 in vivo. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.010DOI Listing
December 2018

Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Republic of Korea. Electronic address:

An overdose of acetaminophen (APAP) causes liver injury through formation of N-acetyl-p-benzoquinoneimine, which overproduces reactive oxygen species (ROS). Autophagy maintains cellular homeostasis and is regulated by generation of ROS. Pterostilbene (PTE) has been shown to have antioxidant and anti-inflammatory properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183088
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http://dx.doi.org/10.1016/j.fct.2018.12.012DOI Listing
December 2018
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Relative potency ranking of azoles altering craniofacial morphogenesis in rats: An in vitro data modelling approach.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Department of Environmental Sciences and Policy, Università degli Studi di Milano, Milan, Italy.

Facial malformations represent one of the most frequent abnormality in humans. The adverse outcome pathway involved in facial defects seems to be related to retinoic acid (RA) pathway imbalance. Environmental agents inducing craniofacial malformations in experimental models include pesticides (especially azole fungicides). Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.004DOI Listing
December 2018

Dietary fish oil supplementation during early pregnancy in rats on a cafeteria-diet prevents fatty liver in adult male offspring.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemistry and Biochemistry, Universidad San Pablo CEU, Madrid, Spain. Electronic address:

We studied in rats the effects of cafeteria diet (CD) supplemented (or not) with fish oil (FO) during just the first 12 days of pregnancy, or during the whole of pregnancy and lactation in 14-month old offspring. Female rats were given standard diet (STD) or CD and after mating some animals remained on STD or CD; for some CD rats the diet was supplemented with 8.78% FO. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.006DOI Listing
December 2018

Grass root approaches to control levels of carcinogenic nitrosamines, NNN and NNK in smokeless tobacco products.

Food Chem Toxicol 2018 Dec 10. Epub 2018 Dec 10.

Division of Preventive Oncology, ICMR-National Institute of Cancer Prevention and Research, Department of Health Research Govt. of India, Noida, India. Electronic address:

Due to the extensive ban on public smoking, tobacco companies focused their business on new smokeless tobacco (SLT) products promoting them as a harm reduction strategy and a safer alternative to cigarettes. Two nitrosamines, N'-nitrosonornicotine (NNN) and nicotine-derived nitrosamine ketone (NNK), present in SLT, listed as group 1 human carcinogens by the International Agency for Research on Cancer, are found to be the prime agents for most of cancers in SLT users. This review illustrates the mechanism of cancer induction by NNN and NNK in humans along with factors influencing the formation of NNN and NNK at various stages of tobacco manufacturing. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.011DOI Listing
December 2018

Consumption and exposure to finished cosmetic products: A systematic review.

Food Chem Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Safety Assessment Department, Pierre Fabre Dermo Cosmetique, Allée Camille Soula - BP 74 Vigoulet Auzil, 31322, Castanet Tolosan - Cedex, France.

According to the European Regulation (EC) No. 1223/2009, cosmetic products should be safe for human health when used under normal or foreseeable conditions of use. To perform a safety evaluation, consumption data of finished cosmetic product are necessary to assess the corresponding consumer's exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183086
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http://dx.doi.org/10.1016/j.fct.2018.11.060DOI Listing
December 2018
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Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.

Food Chem Toxicol 2018 Dec 5;124:182-191. Epub 2018 Dec 5.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The liver is the most essential organ of the body performing vital functions. Hepatic disorders affect the physiological and biochemical functions of the body. These disorders include hepatitis B, hepatitis C, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), liver cirrhosis, hepatic failure and hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.002DOI Listing
December 2018

Apios americana Medik flowers extract protects PC12 cells against HO induced neurotoxicity via regulating autophagy.

Food Chem Toxicol 2018 Dec 7;124:231-238. Epub 2018 Dec 7.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, 310058, PR China; Zhejiang Key Laboratory for Agro-food Processing, Zhejiang University, Hangzhou, 310058, PR China; Fuli Institute of Food Science, Zhejiang University, Hangzhou, 310058, PR China. Electronic address:

Since flavonoids are antioxidant compounds, they could beneficially affect neurodegenerative diseases where reactive oxygen species are involved. In this study, we firstly isolated and identified fourteen compounds from the flowers of Apios americana Medik. Then, we tested whether Apios americana Medik flowers water extract (AFWE) exerts a protective effect on HO induced PC12 cells injure. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.003DOI Listing
December 2018

Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway.

Food Chem Toxicol 2018 Dec 7;124:219-230. Epub 2018 Dec 7.

Institute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, 40402, Taiwan. Electronic address:

Antrodia salonea (AS), a fungus that is indigenous to Taiwan has been well known for its anti-cancer properties. We investigated the anti-metastatic and anti-epithelial-mesenchymal transition (EMT) properties of AS in TNBC cells. To determine their EMT and metastasis levels, in vitro wound healing, wound invasion, Western blotting, RT-PCR, luciferase activity and immunofluorescence assays were performed, while the in vivo anti-metastatic efficacy of AS was evaluated in BALB/c-nu mice through bioluminescence imaging, HE staining, and immunohistochemical staining. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.009DOI Listing
December 2018

Aqueous bark extract of Terminalia arjuna protects against cadmium-induced hepatic and cardiac injuries in male Wistar rats through antioxidative mechanisms.

Food Chem Toxicol 2018 Dec 7;124:249-264. Epub 2018 Dec 7.

Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, 92, APC Road, Kolkata, 700009, India. Electronic address:

Cadmium (Cd) is one of the most ubiquitous toxic heavy metal in the environment. The present study was conducted to evaluate the protective role of aqueous bark extract of Terminalia arjuna (TA) against Cd induced oxidative damage in hepatic and cardiac tissues as the TA bark extract has folkloric medicinal use in the treatment of various hepatic and cardiac disorders. Male Wistar rats were divided into 4 groups. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.008DOI Listing
December 2018

The cytotoxicity activity of Hohenbuehelia serotina polyphenols on HeLa cells via induction of cell apoptosis and cell cycle arrest.

Food Chem Toxicol 2018 Dec 7;124:239-248. Epub 2018 Dec 7.

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150090, PR China. Electronic address:

Hohenbuehelia serotina, is not only one important source of polysaccharides but also a good origin of polyphenols with antineoplastic functions in non-clinical researches. In this study, the polyphenols from H. serotina (HSP) were mainly composed by caffeic acid dimer, (-)-epicatechin-3-(3'-o-methyl)-gallic acid dimer, quercetin-acetyl-rutinoside hexoside, (-)-epigallocatechin derivatives, rutin derivatives, catechin trimer and 3-caffeoylquinic acid. Read More

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http://dx.doi.org/10.1016/j.fct.2018.12.001DOI Listing
December 2018

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 4;124:139-150. Epub 2018 Dec 4.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.061DOI Listing
December 2018
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Resveratrol analog, N-(4-methoxyphenyl)-3,5-dimethoxybenzamide induces G/M phase cell cycle arrest and apoptosis in HeLa human cervical cancer cells.

Food Chem Toxicol 2018 Nov 30;124:101-111. Epub 2018 Nov 30.

Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul, 02447, Republic of Korea; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul, 02447, Republic of Korea. Electronic address:

In this study, several resveratrol analogs were synthesized and evaluated in search of a more effective anti-proliferative resveratrol analog. Among the evaluated resveratrol analogs, we have identified N-(4-methoxyphenyl)-3,5-dimethoxybenamide (MPDB) as a potent anti-proliferative compound. Treatment with MPDB resulted in G/M phase cell cycle arrest, which was accompanied by alteration of G/M-related protein expression and phosphorylation. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.062DOI Listing
November 2018

ZnO nanoparticles affect nutrient transport in an in vitro model of the small intestine.

Food Chem Toxicol 2018 Nov 29;124:112-127. Epub 2018 Nov 29.

Department of Biomedical Engineering, Binghamton University, Binghamton, NY, 13902, USA. Electronic address:

Nano-sized zinc oxide (ZnO) is present in food packaging, putting consumers at risk of ingestion. There is little information on the amount of ZnO nanoparticles (NP) present in food packaging and the effects of ZnO NP ingestion on intestinal function. To estimate physiologically relevant ZnO NP exposures from food that are commonly packaged with ZnO NP, food samples were analyzed with inductively coupled plasma mass spectrometry (ICP-MS). Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.048DOI Listing
November 2018

Suppressive effects of rare ginsenosides, Rk1 and Rg5, on HMGB1-mediated septic responses.

Food Chem Toxicol 2018 Nov 26;124:45-53. Epub 2018 Nov 26.

College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

High mobility group box 1 (HMGB1) is considered to be a late mediator of sepsis. The inhibition of HMGB1-mediated severe inflammatory response and restoration of endothelial integrity have emerged as attractive therapeutic strategies for the management of sepsis. Rare ginsenosides, Rk1 (SB1) and Rg5 (SB2), are among the main components of black ginseng and are prepared from ginsenoside Rd by steaming at 120 °C for 3 h. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.057DOI Listing
November 2018
1 Read

Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats.

Food Chem Toxicol 2018 Nov 26;124:64-80. Epub 2018 Nov 26.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, 700054, India. Electronic address:

One of the major consequences of diabetes is reproductive dysfunction but the fundamental mechanisms are still poorly known. The objective of the present study was to explore the beneficial role of taurine against streptozotocin induced testicular dysfunctions in diabetic male Wister rats and understanding the underlying intricate molecular mechanisms. Exposure to streptozotocin (50 mg kg body weight, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183085
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http://dx.doi.org/10.1016/j.fct.2018.11.055DOI Listing
November 2018
4 Reads
2.895 Impact Factor

Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin produces a superior neuroprotective and behavioral profile in a mice model of Parkinson's disease.

Food Chem Toxicol 2018 Nov 24;124:17-29. Epub 2018 Nov 24.

Department of Biosciences, Universidade Federal de São Paulo, Rua Silva Jardim, 136, CEP 11015-020, Santos, SP, Brazil. Electronic address:

Evidence indicates that oxidative stress has an important role in the onset and progression of Parkinson's disease (PD). Antioxidant agents from natural products have shown neuroprotective effects in animal models of PD. Eplingiella fruticosa is an aromatic and medicinal plant of the Lamiaceae family that include culinary herbs. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.056DOI Listing
November 2018
1 Read

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Food Chem Toxicol 2018 Nov 24;124:192-218. Epub 2018 Nov 24.

Scientific Secretary to the FEMA Expert Panel, 1101 17th Street, NW Suite 700, Washington, DC, 20036, USA. Electronic address:

In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavoring ingredients. This publication is the first in a series and summarizes the evaluation of 54 Citrus-derived NFCs using the procedure outlined in Smith et al. (2005) and updated in Cohen et al. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.052DOI Listing
November 2018

Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils.

Food Chem Toxicol 2018 Nov 24;124:1-9. Epub 2018 Nov 24.

Center of Plant Systems Biology and Biotechnology, 4000, Plovdiv, Bulgaria; Group of Plant Cell Biotechnology and Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000, Plovdiv, Bulgaria. Electronic address:

Clinopodium vulgare L. (wild basil) has a wide range of ethnopharmacological applications and accumulates a broad spectrum of phenolic compounds, recognized for their anti-inflammatory and anticancer properties. The triggered cyclooxygenase-2 (COX-2) expression is creating an immunosuppressive microenvironment in the inflamed tissue and considered to be the main cause of failure of even new anticancer-/immune-therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183085
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http://dx.doi.org/10.1016/j.fct.2018.11.054DOI Listing
November 2018
4 Reads

Adverse drug reactions of anticancer drugs derived from natural sources.

Food Chem Toxicol 2018 Nov 22;123:522-535. Epub 2018 Nov 22.

Value Addition Research and Development-Human Health, National Innovation Foundation-India, Autonomous Body of Department of Science and Technology, Govt. of India, Grambharti, Mahudi Road, Gandhinagar, 382650, Gujarat, India. Electronic address:

Cancer, a life threatening disease adversely affects huge population worldwide. Naturally derived drug discovery has emerged as a potential pathway in search of anticancers. Natural products-based drugs are generally considered safe, compared to their synthetic counterparts. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.041DOI Listing
November 2018
2 Reads

Editorial: Mechanism of mycotoxins.

Food Chem Toxicol 2018 Nov 20;123:520-521. Epub 2018 Nov 20.

Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.

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http://dx.doi.org/10.1016/j.fct.2018.11.044DOI Listing
November 2018

Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods.

Food Chem Toxicol 2018 Nov 20;124:81-100. Epub 2018 Nov 20.

Department of Pharmacology & Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are known to contaminate a large portion of the world's food supply. Aflatoxin B1 (AFB1) is the most potent of these compounds and has been well-characterized to lead to the development of hepatocellular carcinoma (HCC) in humans and animals. This review focuses on the metabolism of AFB1, including epoxidation and DNA adduction, as it concerns the initiation of cancer and the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.047DOI Listing
November 2018
6 Reads

Presence of unreported carcinogens, Aflatoxins and their hydroxylated metabolites, in industrialized Oaxaca cheese from Mexico City.

Food Chem Toxicol 2018 Nov 20;124:128-138. Epub 2018 Nov 20.

Departamento de Química Analítica, Facultad de Química, Ciudad Universitaria, Universidad Nacional Autónoma de México (UNAM), CP 04510, CdMx, Mexico.

Aflatoxins (AFs) are toxic secondary metabolites of the fungi Aspergillus flavus, A. parasiticus and A. nomius. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.046DOI Listing
November 2018
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Chemical-specific maximum allowable levels for pesticide residues in dietary supplements.

Food Chem Toxicol 2018 Nov 20;123:511-519. Epub 2018 Nov 20.

NSF International, 789 N. Dixboro Rd, Ann Arbor, MI, 48105, USA. Electronic address:

Dietary supplements are regulated by the U.S. FDA as a subset of foods. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.045DOI Listing
November 2018
6 Reads

Safety assessment of EPA+DHA canola oil by fatty acid profile comparison to various edible oils and fat-containing foods and a 28-day repeated dose toxicity study in rats.

Food Chem Toxicol 2018 Nov 19;124:168-181. Epub 2018 Nov 19.

BASF Plant Science, L.P., 26 Davis Drive, Research Triangle Park, NC, 27709, USA. Electronic address:

The omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are recognized for their health-promoting qualities. Marine fish and fish oil currently provide the main sources of EPA and DHA for human consumption. An alternative plant-based source of EPA and DHA is provided by EPA + DHA canola event LBFLFK (LBFLFK). Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.042DOI Listing
November 2018
7 Reads

Preventive role of Pycnogenol against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats.

Food Chem Toxicol 2018 Nov 19;124:54-63. Epub 2018 Nov 19.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Ankara, Turkey.

Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.038DOI Listing
November 2018
2 Reads
2.895 Impact Factor

Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells.

Food Chem Toxicol 2018 Nov 19;124:30-44. Epub 2018 Nov 19.

Institute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, 40402, Taiwan. Electronic address:

The medicinal fungus Ganoderma, known in Chinese as Lingzhi or Reishi, traditionally has various medicinal uses and has been employed in cancer treatment in Asia for centuries. This study used ethanol-extracted Ganoderma tsugae (GT) and examined its antitumor activities on human chronic myeloid leukemia cells as well as its molecular mechanism of action. Treatment with GT (200-400 μg/mL) significantly reduced cell viability and caused G2/M arrest in K562 cells. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.043DOI Listing
November 2018
3 Reads
2.900 Impact Factor

Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil.

Food Chem Toxicol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53792, USA; Department of Internal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53792, USA; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53792, USA.

Fludioxonil is a phenylpyrrole pesticide that is applied to fruit and vegetable crops post-harvest to minimize losses to mold, both during transport and at point of sale. Its effectiveness is reflected in the dramatic increase in its production/usage since its introduction in 1994, an increase that has peaked in recent years as it became licenced for use abroad. Recently, doubts as to the nature of its mechanism of action have been raised. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183083
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http://dx.doi.org/10.1016/j.fct.2018.11.037DOI Listing
November 2018
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Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells.

Food Chem Toxicol 2018 Nov 17;123:492-500. Epub 2018 Nov 17.

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone) has displayed antitumor activity in vitro and in animal models; however, the underlying molecular mechanisms have not been fully explored. The aim of this study was to investigate the anticancer effects of plumbagin isolated from Nepenthes alata against MCF-7 breast cancer cells. We examined the cytotoxicity, cell cycle regulation, apoptotic cell death, and generation of intracellular reactive oxygen species (ROS) in MCF-7 cells. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.040DOI Listing
November 2018
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The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway.

Food Chem Toxicol 2018 Nov 17;123:481-491. Epub 2018 Nov 17.

German Federal Institute for Risk Assessment, Dept. Food Safety, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Electronic address:

Tebuconazole, a member of the triazole group of fungicides, exerts hepatotoxicity in rodent studies. Knowledge on the molecular mechanisms underlying tebuconazole toxicity is limited. Previous studies suggest that activation of xenobiotic-sensing nuclear receptors plays a role in triazole fungicide-mediated hepatotoxicity. Read More

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http://dx.doi.org/10.1016/j.fct.2018.11.039DOI Listing
November 2018
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3-Monochloropropane-1, 2-diol causes irreversible damage to reproductive ability independent of hormone changes in adult male rats.

Food Chem Toxicol 2018 Nov 16;124:10-16. Epub 2018 Nov 16.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China; Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government, Beijing Laboratory of Food Quality and Safety, China Agricultural University, Beijing, 100083, China.

3-MCPD, a contaminant frequently detected in foodstuffs, has been reported to damage human kidneys and testes. Previous studies can be used to evaluate the risk to humans of exposure to excessive 3-MCPD for a short period. However, the effects of withdrawal after 3-MCPD exposure have rarely been studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183082
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http://dx.doi.org/10.1016/j.fct.2018.11.023DOI Listing
November 2018
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