10,311 results match your criteria Food and Chemical Toxicology [Journal]


Poisoning associated with the use of mushrooms: A review of the global pattern and main characteristics.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Laboratory of Toxicology, University of Crete, Voutes, Heraklion, Crete, 71003, Greece.

Worldwide, special attention has been paid to wild mushrooms-induced poisoning. This review article provides a report on the global pattern and characteristics of mushroom poisoning and identifies the magnitude of mortality induced by mushroom poisoning. In this work, reasons underlying mushrooms-induced poisoning, and contamination of edible mushrooms by heavy metals and radionuclides, are provided. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193021
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http://dx.doi.org/10.1016/j.fct.2019.04.016DOI Listing
April 2019
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Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ aggregation.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50 - 50134, Florence, Italy; Interuniversity Center for the Study of Neurodegenerative Diseases (CIMN), Florence, Italy. Electronic address:

Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ fibrillation, a main histopathological feature of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.015DOI Listing

Anti-diabetic activity of PUFAs-rich extracts of Chlorella pyrenoidosa and Spirulina platensis in rats.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China. Electronic address:

The contributions to hypoglycemic function and gut microbiota regulation by water and ethanol extracts of the microalgae Chlorella pyrenoidosa and Spirulina platensis were determined. An ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis indicated that most of the compounds in the 55% ethanol extracts of C. pyrenoidosa (CP55) and S. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.017DOI Listing

Natural products: An upcoming therapeutic approach to cancer.

Food Chem Toxicol 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India. Electronic address:

Cancer is one of the leading causes of death across the world. Different environmental and anthropogenic factors initiate mutations in different functional genes of growth factors and their receptors, anti-apoptotic proteins, self-renewal developmental proteins, tumor suppressors, transcription factors, etc. This phenomenon leads to altered protein homeostasis of the cell which in turn induces cancer initiation, development, progression and survival. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.012DOI Listing

Reproductive toxicity of perchlorate in rats.

Food Chem Toxicol 2019 Apr 13. Epub 2019 Apr 13.

Harbin Medical University Library, 194 XueFu Road, NanGang District, Harbin, 150081, People's Republic of China. Electronic address:

Perchlorate, as an oxidizer, has many applications such as explosives and pyrotechnics, especially in rocket propellants and missile motors. Because it was found in water including wells and drinking water in the US, its effect on human health was being noted. However, the reproductive toxic effect on perchlorate is still unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193021
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http://dx.doi.org/10.1016/j.fct.2019.04.014DOI Listing
April 2019
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Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies.

Food Chem Toxicol 2019 Apr 13. Epub 2019 Apr 13.

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901, Ribeirão Preto - SP, Brazil. Electronic address:

Myclobutanil is a chiral triazole fungicide that is employed worldwide. Although enantiomers have the same physical-chemical properties, they may differ in terms of activity, metabolism, and toxicity. This investigation consisted of in vitro enantioselective metabolism studies that employed a human model to assess the risks of myclobutanil in humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193020
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http://dx.doi.org/10.1016/j.fct.2019.04.009DOI Listing
April 2019
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Food flavonoid ligand structure/estrogen receptor-α affinity relationships - Toxicity or food functionality?

Authors:
Hui Ye Ian C Shaw

Food Chem Toxicol 2019 Apr 12. Epub 2019 Apr 12.

Human Toxicology Research Group, School of Physical and Chemical Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand. Electronic address:

In silico molecular modelling is used to study interactions between flavonoid phytoestrogens and estrogen receptor (ER)α. Twenty flavonoids from foods were studied; e.g. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.008DOI Listing

Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring.

Food Chem Toxicol 2019 Apr 12;128:193-201. Epub 2019 Apr 12.

Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Reus, Catalonia, Spain. Electronic address:

This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.013DOI Listing

Identification of phenolic compounds from a unique citrus species, finger lime (Citrus australasica) and their inhibition of LPS-induced NO-releasing in BV-2 cell line.

Food Chem Toxicol 2019 Apr 9. Epub 2019 Apr 9.

Laboratory of Fruit Quality Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Fruit Science Institute, Zhejiang University, Zijingang Campus, Hangzhou, 310058, PR China. Electronic address:

In this study, a unique citrus species (Citrus australasica) was selected, and its fruit characteristics, phenolic compounds and ability to inhibit inflammation were preliminarily studied. Finger lime fruits showed distinctive features in shape, size, weight, colour, total soluble solids, water-soluble pectin, sugar and acids contents. Combining UPLC-HRMS and UPLC-DAD analysis, 31 phenolics, 1 secoiridoid derivative and 1 neolignan glycoside were preliminarily identified and quantified. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.006DOI Listing
April 2019
2 Reads

Estimates of dietary exposure of Spanish population to packaging contaminants from cereal based foods contained in plastic materials.

Food Chem Toxicol 2019 Apr 8;128:180-192. Epub 2019 Apr 8.

Faculty of Pharmacy, Department of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. Electronic address:

Food packaging may be a potential source of contamination, through the migration of chemicals from the packaging into the food, thus food consumption is an important route of human exposure to packaging contaminants. In the present study an approach to estimate the exposure to different chemicals transferred from food packaging was designed. As a first step a GC-MS screening was conducted to identify potential contaminants in the materials. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.003DOI Listing

Corrigendum to "The application of new HARD-descriptor available from the CORAL software to building up NOAEL models" [Food Chem. Toxicol. 112 (2018) 544-550].

Food Chem Toxicol 2019 Apr 7;128:146. Epub 2019 Apr 7.

Department of Environmental Health Science, Laboratory of Environmental Chemistry and Toxicology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20156, Milano, Italy.

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http://dx.doi.org/10.1016/j.fct.2019.04.004DOI Listing
April 2019
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Mycotoxins in uncooked and plate-ready household food from rural northern Nigeria.

Food Chem Toxicol 2019 Apr 6;128:171-179. Epub 2019 Apr 6.

Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences Vienna (BOKU), Konrad Lorenzstr. 20, A-3430, Tulln, Austria; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, University Road, Belfast, BT7 1NN, Northern Ireland, United Kingdom.

In order to understand the changes in toxic metabolite profiles in uncooked and cooked foods, samples of flour/grain (n = 40) and their corresponding plate-ready food (n = 39) were collected from 40 households in two states of northern Nigeria. The food samples were analyzed for multiple fungal metabolites by LC-MS/MS and daily intakes of mycotoxins in the diets were estimated and compared to established margin of exposure (MOE) and tolerable daily intake (TDI) values. Both food groups contained 65 fungal and plant metabolites, inclusive of 23 mycotoxins. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.002DOI Listing

Applicability of a human cell co-culture model to evaluate antioxidant responses triggered by chemical mixtures in fish and oyster homogenates.

Food Chem Toxicol 2019 Apr 6;128:154-162. Epub 2019 Apr 6.

Department of Environmental Science, Baylor University, Waco, TX, 76798, USA. Electronic address:

The accumulation of chemical compounds in fish tissue represents significant health concerns for seafood consumers, but little is known about the risks to human health associated with such substances. The identification of adverse biological responses upon exposure to contaminants has been facilitated by the development of in vitro systems resembling the human dietary pathway. The present study explores the applicability of an organotypic co-culture system, using intestinal (Caco-2) and hepatic (HepaRG) cell lines, to provide insight into the toxicity of chemical mixtures found in commercially available seafood. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.005DOI Listing
April 2019
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Effect of lactic acid bacteria on mercury toxicokinetics.

Food Chem Toxicol 2019 Apr 6;128:147-153. Epub 2019 Apr 6.

Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), C/ Agustín Escardino 7, 46980, Paterna, Valencia, Spain. Electronic address:

The capacity of two LAB strains to inhibit inorganic [Hg(II)] and organic (methyl-Hg; MeHg) mercury translocation through monolayers of co-cultures of NCM460 and HT29-MTX colonic cells was evaluated. Lactobacillus casei BL23 and Lactobacillus acidophilus ATCC4356 reduced the permeability of Hg(II) and MeHg from aqueous solutions through NCM460/HT29-MTX monolayers (20-94% reduction). However, assays using the bioaccessible (soluble) Hg fraction obtained by in vitro gastrointestinal digestion of Hg-contaminated swordfish only showed a reduction (42%) with the BL23 strain. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.001DOI Listing

Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment.

Food Chem Toxicol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

Prenatal nicotine exposure (PNE) could induce ovarian dysplasia in offspring. This study aimed to confirm its intrauterine origin and explore a programming mechanism of ovarian dysplasia caused by PNE. Pregnant Wistar rats were injected subcutaneously with nicotine (2 mg/kg. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.055DOI Listing
April 2019
2.895 Impact Factor

Development of quantitative structure-activity relationship models to predict potential nephrotoxic ingredients in traditional Chinese medicines.

Food Chem Toxicol 2019 Apr 4;128:163-170. Epub 2019 Apr 4.

Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, China; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Beijing, 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, China. Electronic address:

The broad use of traditional Chinese medicines (TCMs) and the accompanied incidences of kidney injury have attracted considerable interest in investigating the responsible toxic ingredients. It is challenging to evaluate toxicity of TCMs since they contain complex mixtures of phytochemicals. Quantitative structure-activity relationship (QSAR) is an efficient tool to predict toxicity and QSAR study on TCMs-induced nephrotoxicity remains lacked. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.056DOI Listing
April 2019
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Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides.

Food Chem Toxicol 2019 Apr 3;128:137-145. Epub 2019 Apr 3.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

Glyphosate is the active ingredient in glyphosate-based herbicides (GBHs). Other chemicals in GBHs are presumed as inert by regulatory authorities and are largely ignored in pesticide safety evaluations. We identified the surfactants in a cross-section of GBH formulations and compared their acute toxic effects. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.053DOI Listing

Insight into the formation, structure and digestibility of lotus seed amylose-fatty acid complexes prepared by high hydrostatic pressure.

Food Chem Toxicol 2019 Apr 2;128:81-88. Epub 2019 Apr 2.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, PR China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fuzhou, Fujian, PR China; China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, PR China. Electronic address:

Lotus seed amylose-fatty acid complexes were prepared using high hydrostatic pressure and the relationship between their structural properties and digestibility was investigated. The formation of lotus seed amylose-fatty acid complexes increased the values of weight molar mass (Mw), number molar mass (Mn), polydispersity index and resistant starch content compared to those of amylose controls. Mw and Mn values of lotus seed amylose and complexes decreased with an increase in high hydrostatic pressure from 500 MPa to 600 MPa, suggesting that the lotus seed amylose was decomposed into short glucan chains. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.052DOI Listing

A novel chrysin derivative produced by gamma irradiation attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Balb/c mice.

Food Chem Toxicol 2019 Apr 1. Epub 2019 Apr 1.

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29, Geumgu-gil, Jeongup, Jeongbuk, 56212, Republic of Korea. Electronic address:

Gamma irradiation is a useful technology to change the physical and biological properties of natural molecules. In this study, we investigated whether gamma irradiation improve properties of chrysin as an anti-inflammatory candidates. Chrysin was converted into two compounds (CM1 and CM2) by gamma irradiation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193017
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http://dx.doi.org/10.1016/j.fct.2019.03.048DOI Listing
April 2019
4 Reads

Effects of thermal preparation and in vitro digestion on lignan profiles and antioxidant activity in defatted-sesame meal.

Food Chem Toxicol 2019 Apr 1;128:89-96. Epub 2019 Apr 1.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Defatted-sesame meal (DSM), a byproduct of sesame oil, has attracted considerable interest in the food industry because of its strong antioxidant activity. The aim of this study was to measure the content and distribution of lignans in DSM and evaluate their antioxidant activity after thermal processing and in vitro digestion. The results showed that the sesame lignans (SL) content and antioxidant activity were significantly influenced by the temperature and time during thermal preparation, and the maximum antioxidant potency composite index (ACI) was obtained after roasting the samples at 240 °C for 20 min. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.054DOI Listing

Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes.

Food Chem Toxicol 2019 Mar 30;128:129-136. Epub 2019 Mar 30.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, United Kingdom. Electronic address:

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193017
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http://dx.doi.org/10.1016/j.fct.2019.03.050DOI Listing
March 2019
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2.895 Impact Factor

Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats.

Food Chem Toxicol 2019 Mar 30;128:61-67. Epub 2019 Mar 30.

CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal. Electronic address:

Garcinia cambogia supplements are widely used for weight loss. Knowing that epilepsy patients are at greater risk of developing overweight/obesity, the investigation of herb-drug interactions involving antiepileptic drugs of narrow therapeutic index is fully justified. This work was planned to assess potential pharmacokinetic-based interactions between G. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.051DOI Listing
March 2019
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The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase.

Food Chem Toxicol 2019 Mar 29;128:35-45. Epub 2019 Mar 29.

ProCURE (Program Against Cancer Therapeutic Resistance), Metabolism & Cancer Group, Catalan Institute of Oncology, Girona, Spain; Girona Biomedical Research Institute (IDIBGI), Girona, Spain. Electronic address:

Catechol-containing polyphenols present in coffee and tea, while serving as excellent substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also operate as COMT inhibitors. However, little is known about the relationship between COMT and the characteristic phenolics present in extra virgin olive oil (EVOO). We here selected the EVOO dihydroxy-phenol oleacein for a computational study of COMT-driven methylation using classic molecular docking/molecular dynamics simulations and hybrid quantum mechanical/molecular mechanics, which were supported by in vitro activity studies using human COMT. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.049DOI Listing
March 2019
2 Reads

Chemistry and immunostimulatory activity of a polysaccharide from Undaria pinnatifida.

Food Chem Toxicol 2019 Mar 26;128:119-128. Epub 2019 Mar 26.

School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, People's Republic of China; Overseas Expertise Introduction Center for Food Nutrition and Human Health (111 Center), Guangzhou, 510640, People's Republic of China. Electronic address:

An immunologically active polysaccharide named as UPP-2 (1035.52 kDa) was isolated from Undaria pinnatifida using traditional water extraction followed by DEAE Sepharose fast flow chromatography. UPP-2 was proven to be a low sulfated polysaccharide with relatively abundant uronic acid (13. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.042DOI Listing

Assessment of mycotoxin exposure and risk characterization using occurrence data in foods and urinary biomarkers in Brazil.

Food Chem Toxicol 2019 Mar 27;128:21-34. Epub 2019 Mar 27.

Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, Av. Duque de Caxias Norte, 225, CEP 13635-900, Pirassununga, SP, Brazil. Electronic address:

This study aimed to assess the exposure of Brazilian residents (N = 86) from rural areas to multiple mycotoxins and characterize the associated risk in two sampling periods (SP) (April-May and December/2016). Mycotoxins in food and urine samples were determined by liquid chromatography coupled to tandem mass spectrometry. Mean probable daily intake (PDI) values based on occurrence data in foods in both SP varied from 0. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.046DOI Listing
March 2019
1 Read

Food components and environmental chemicals of inhibiting human placental aromatase.

Food Chem Toxicol 2019 Mar 25;128:46-53. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Human placental CYP19A1 catalyzes the estrogen synthesis from androgens. The enzyme is encoded by CYP19A1 gene located in chromosome 15q21. This enzyme is a monooxygenase in the smooth endoplasmic reticulum. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.043DOI Listing
March 2019
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2.895 Impact Factor

Mequindox induces apoptosis, DNA damage, and carcinogenicity in Wistar rats.

Food Chem Toxicol 2019 May 25;127:270-279. Epub 2019 Mar 25.

National Reference Laboratory of Veterinary Drug Residues (HZAU), MAO Key Laboratory for Detection of Veterinary Drug Residues, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

Mequindox (MEQ) is a synthetic antibacterial agent. Recent studies showed that MEQ and its primary metabolites exhibit strong genotoxicity to mammalian cells, and MEQ induced carcinogenicity in mice. These findings suggest that chronic exposure to MEQ could lead to an increased risk of cancer later in life. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.025DOI Listing
May 2019
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Cyanidin chloride modestly protects Caco-2 cells from ZnO nanoparticle exposure probably through the induction of autophagy.

Food Chem Toxicol 2019 May 26;127:251-259. Epub 2019 Mar 26.

Key Laboratory of Environment-Friendly Chemistry and Applications of Ministry Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China. Electronic address:

Recent studies suggest that phytochemicals, as part of the food matrix, might alter the toxicity of nanoparticles (NPs); however, relatively few studies have investigated the impact of anthocyanidins on the toxicity of NPs to cells lining the gastrointestinal tract. Therefore, this study used cyanidin chloride (CC) as the model for anthocyanidins and investigated the effects of CC on the toxicity of ZnO or Ag NPs to Caco-2 cells. Exposure to ZnO but not Ag NPs significantly induced cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.047DOI Listing

Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies.

Food Chem Toxicol 2019 May 25;127:228-236. Epub 2019 Mar 25.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Mushrooms are important sources of natural bioactive compounds that are increasingly used as cosmeceutical ingredients. In this context, ethanolic extracts were prepared from Ganoderma lucidum and Pleurotus ostreatus and tested by incorporation into base cosmetic creams. In vitro safety evaluation of the extracts and cosmetic formulations prepared therefore was carried out using the MTT and LDH assays in keratinocyte (HaCaT) and fibroblast (HFF-1) cell lines. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.045DOI Listing
May 2019
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2.895 Impact Factor

Cyanidin-3-O-glucoside promotes progesterone secretion by improving cells viability and mitochondrial function in cadmium-sulfate-damaged R2C cells.

Food Chem Toxicol 2019 Mar 23;128:97-105. Epub 2019 Mar 23.

Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. Electronic address:

Cadmium (Cd) is a poisonous metal that is toxic for male reproduction. Cyanidin-3-O-glucoside (C3G) as typical anthocyanin benefits many organs. In this study, we investigated the protective effects and associated underlying mechanisms of C3G against the toxicity of Cd on male reproduction in rat Leydig cell line R2C cells. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.040DOI Listing

Distribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents.

Food Chem Toxicol 2019 Mar 23;128:68-80. Epub 2019 Mar 23.

University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Višegradska 33, 18000, Niš, Serbia. Electronic address:

Two volatile alkaloids, methyl (MMA) and isopropyl N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been proven to possess polypharmacological properties (antinociceptive, anti-inflammatory, gastro-, hepato-, nephroprotective activities, anxiolytic and antidepressant properties, and likewise an effect on diazepam-induced sleep). In the continuation of our investigation of their urinary-metabolite profiles, we performed GC-MS analyses of the diethyl-ether extracts of selected tissues (liver, kidneys, heart, brain, lungs, quadriceps femoris muscle, and spleen) of rats intraperitoneally treated with MMA or IMA (2 g kg). Organ-metabolite profiles of MMA and IMA were qualitatively mutually analogous (varying only in the alcohol moiety of the metabolites), and generally analogous to their urinary-metabolite profiles. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.039DOI Listing

Cancer risk estimation of glycidol based on rodent carcinogenicity studies, a multiplicative risk model and in vivo dosimetry.

Food Chem Toxicol 2019 Mar 23;128:54-60. Epub 2019 Mar 23.

Department of Environmental Science and Analytical Chemistry, Stockholm University, Sweden. Electronic address:

Here we evaluate a multiplicative (relative) risk model for improved cancer risk estimation of genotoxic compounds. According to this model, cancer risk is proportional to the background tumor incidence and to the internal dose of the genotoxic compound. Furthermore, the relative risk coefficient per internal dose is considered to be approximately the same across tumor sites, sex, and species. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.037DOI Listing

Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus.

Food Chem Toxicol 2019 May 23;127:237-250. Epub 2019 Mar 23.

Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius.

In the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.041DOI Listing
May 2019
4 Reads

Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats.

Food Chem Toxicol 2019 May 23;127:206-217. Epub 2019 Mar 23.

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa. Electronic address:

The therapeutic effect of the hot water infusion of Cola nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.044DOI Listing

Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells.

Food Chem Toxicol 2019 May 23;127:182-187. Epub 2019 Mar 23.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:

The crude extract of Sonchus oleraceus Linn (CE) and its main phenolic acids (PA), chlorogenic acid and caffeic acid have anti-diabetic activity, but the mechanisms for their effects on glucose intake remain largely unknown. Aim of this study was to examine the synergistic effect of chlorogenic and caffeic acid from S. oleraceus Linn attenuate insulin resistance and modulate glucose uptake in HepG2 cells. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.038DOI Listing

Combination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO nanoparticles exposure in human keratinocytes.

Food Chem Toxicol 2019 May 22;127:197-205. Epub 2019 Mar 22.

Department of Analytical Chemistry, Faculty of Chemical Sciences. Complutense University of Madrid, 28040, Madrid, Spain. Electronic address:

Titanium dioxide nanoparticles (TiO-NPs) are being used in several consumer products. The high refractive index of nano-scaled titanium dioxide particles allows them to protect from UV radiation, and so, they can be found as one of the main components of cosmetics and suncreens. Many studies have reported the potential toxicological effects associated to TiO-NPs such as ROS generation, DNA damage, apoptosis and cell cycle arrest, among others. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.036DOI Listing

Mitigating effects of apigenin on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes.

Food Chem Toxicol 2019 May 22;127:218-227. Epub 2019 Mar 22.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India. Electronic address:

Edifenphos (EDF) is an Organophosphorus pesticide and used in agriculture for pest control. However, EDF has been shown to accumulate in agricultural products and causes hazards to human health. Although reports are available regarding environmental impact of EDF, toxic effects of EDF on human cellular system especially immune cells have not been elucidated. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.034DOI Listing

Methamphetamine ("crystal meth") causes induction of DNA damage and chromosomal aberrations in human derived cells.

Food Chem Toxicol 2019 Mar 22;128:1-7. Epub 2019 Mar 22.

Institute of Cancer Research, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria. Electronic address:

Methamphetamine (METH) is a widely consumed psychostimulant drug; its acute toxic effects in brain and liver are well known, furthermore, there is some evidence in regard to its DNA damaging properties in humans. Therefore, we studied the impact of the drug on genomic stability in human derived hepatoma (HepG2) cells, which reflect the activation/detoxification of drugs better than other cell lines. Furthermore, experiments with human buccal derived cells (TR146) were conducted as the drug is consumed orally. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.035DOI Listing
March 2019
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Dietary exposure assessment to mycotoxins through total diet studies. A review.

Food Chem Toxicol 2019 Mar 23;128:8-20. Epub 2019 Mar 23.

Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andrés Estellés s/n, 46100, Burjassot, Spain.

Mycotoxins are secondary metabolites of fungi that contaminate food in several stages and their increasing presence in food chain demand further control. Assessment of mycotoxins human exposure through processed diet is an important component of food safety strategies. The present review explores and summarises total diet studies (TDS) carried out in different countries focusing on mycotoxins determination. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.033DOI Listing

Assessment of targeted non-intentionally added substances in cosmetics in contact with plastic packagings. Analytical and toxicological aspects.

Food Chem Toxicol 2019 Mar 21;128:106-118. Epub 2019 Mar 21.

Laboratoire de Chimie Agro-Industrielle (LCA), Université de Toulouse, INRA, INPT, Toulouse, France.

Container-content interactions are common in the food and pharmaceutical industries. However, these studies are more complicated in the cosmetic industry, and it is necessary to ensure consumer safety. The objective of this work was to develop a strategy for the toxicological evaluation of leachables for cosmetic packagings. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.030DOI Listing
March 2019
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Exposure source for skin sensitizing hydroperoxides of limonene and linalool remains elusive: An analytical market surveillance.

Food Chem Toxicol 2019 May 21;127:156-162. Epub 2019 Mar 21.

IDEA Management Team, Avenue des Arts 6, 1210, Brussels, Belgium.

Positive patch test reactions of dermatological patients to oxidized samples of linalool and limonene are frequently reported. The sensitizing ingredients in the oxidation mixtures are hydroperoxides (HP). It is not clear whether fragranced consumer products are a relevant exposure source for HP. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.028DOI Listing

Do conventional cooking methods alter concentrations of per- and polyfluoroalkyl substances (PFASs) in seafood?

Food Chem Toxicol 2019 May 21;127:280-287. Epub 2019 Mar 21.

The University of Queensland, Queensland Alliance for Environmental Health Sciences, 20 Cornwall Street, Woolloongabba, QLD, 4102, Australia.

Per-and poly-fluoroalkyl substances (PFASs) are bioaccumulative chemicals of emerging concern. Some PFASs accumulate in seafood, and can contribute to dietary exposure. Previous work has suggested cooking seafood decreases concentrations of neutral organic contaminants, however, previous studies dealing with PFASs have shown conflicting results. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.032DOI Listing

Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells.

Food Chem Toxicol 2019 May 21;127:188-196. Epub 2019 Mar 21.

Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, Guangdong, 519031, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.029DOI Listing

Receptor-based aggregate exposure assessment of phthalates based on individual's simultaneous use of multiple cosmetic products.

Food Chem Toxicol 2019 May 20;127:163-172. Epub 2019 Mar 20.

Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea; Institute of Health and Environment, Seoul National University, Seoul, South Korea. Electronic address:

To estimate realistic exposure to a chemical, the aggregate exposure from multiple consumer products should be considered. A receptor-based aggregate exposure assessment was conducted according to individuals' exposure factors and simultaneous use patterns including co-use and non-use. A product-based aggregate exposure assessment was conducted by product usage rates of population and users' exposure factors. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.031DOI Listing

Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population.

Food Chem Toxicol 2019 May 18;127:260-269. Epub 2019 Mar 18.

Centre of Toxicology Science and Research, University of Crete, School of Medicine, Crete, Greece.

Health benefits of fish consumption could be counterbalanced by the intake of contaminants after long term fish consumption, burdened even in trace levels. The presence of the indicator PCBs (NDL-PCBs and PCB 118) in farmed and wild seabream and seabass was evaluated. For the determination of PCB, a GC-MS method was developed and evaluated. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.027DOI Listing
May 2019
2.895 Impact Factor