1,071,828 results match your criteria Food Policy [Journal]
Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,
Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More
Cell Physiol Biochem 2018 11;51(5):2397-2420. Epub 2018 Dec 11.
Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing,
Background/aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis. Our previous studies suggested that resveratrol (RSV) supplement could improve hepatic steatosis, but the underlying mechanism, particularly which related to LD accumulation, has not yet been elucidated.
Methods: A high-fat diet (HFD) and palmitic acid were used to induce hepatic steatosis in mouse liver and hepatocytes, respectively. Read More
Obes Facts 2018 Dec 11;11(6):501-513. Epub 2018 Dec 11.
Department of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.
Objectives: The study investigated whether treatment options for episodic tension-type headache vary among general practitioners (GPs) in Denmark depending on the patients' weight status and gender, and whether these decisions can be explained by the GPs' own anti-fat bias and lifestyle.
Methods: A cross-sectional questionnaire study with responses from 240 GPs on measures of anti-fat bias, healthiness of GPs' lifestyles, and reported patient treatment decisions.
Results: GPs tended to exhibit negative explicit and implicit anti-fat bias. Read More
Obes Facts 2018 Dec 11;11(6):440-453. Epub 2018 Dec 11.
Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal,
Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats.
Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Read More
Psychiatry Res 2018 Dec 4;271:428-437. Epub 2018 Dec 4.
Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran; Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
A number of studies have examined the association between diet and mood state, but the findings have been inconclusive. Herein, we conducted a systematic review to assess the association between different diet and mood state. PubMed, Cochrane's library, Science direct, Scopus, Google scholar and ISI web of science databases were searched for all available literature until December 2017 for studies assessing the association between diet and mood state. Read More
Environ Pollut 2018 Nov 30;246:124-130. Epub 2018 Nov 30.
Department of Environmental Science, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, Zhejiang 310058, China. Electronic address:
Predicting the translocation of organic contaminants to plants is crucial to ensure the quality of agricultural goods and assess the risk of human exposure through the food web. In this study, the performance of a modified plant uptake model was evaluated considering a number of chemicals, such as polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs), with a range of physicochemical properties; different plant species (Ipomoea aquatica Forsk (swamp morning glory), Chrysanthemum coronarium L. (crown daisy), Zea mays L. Read More
Int Immunopharmacol 2018 Dec 8;67:98-105. Epub 2018 Dec 8.
Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Republic of Korea. Electronic address:
The anti-inflammatory effects of 3‑bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol (BEMB) from Polysiphonia morrowii were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells and zebrafish embryo. BEMB showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), and the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in the LPS-activated RAW264. Read More
Colloids Surf B Biointerfaces 2018 Dec 4;175:231-238. Epub 2018 Dec 4.
Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Conventional chemotherapy suffers from several drawbacks, including toxic side effects together with the development of resistance to the chemical agents. Therefore, exploring alternative therapeutic approaches as well as developing targeted delivery systems are in demand. Oligonucleotide-based therapy has emerged as a promising and alternative procedure for treating malignancies involving gene-related diseases. Read More
J Plant Physiol 2018 Nov 16;232:82-93. Epub 2018 Nov 16.
National Research Council of Italy - Institute for Sustainable Plant Protection (CNR-IPSP), Viale P.A. Mattioli 25, 10125 Torino, Italy.
Previous research demonstrated that Pseudomonas chlororaphis subsp. aureofaciens strain M71, a plant growth promoting bacterium (PGPB), exerts beneficial effects on plant metabolism and primes tolerance mechanisms against biotic stresses in tomatoes. We designed an experiment to assess whether root colonization with P. Read More
J Plant Physiol 2018 Nov 22;232:160-170. Epub 2018 Nov 22.
Department of Plant Physiology, Poznań University of Life Sciences, Wołyńska 35, 60-637 Poznań, Poland. Electronic address:
The aim of this study was to determine an interdependence between generation of semiquinone radicals, superoxide anion (O-), manganese ions (Mn) and phenolic content in leaves of Thuja orientalis in response to infestation by varying populations of Cinara tujafilina, i.e. 40 or 80 aphids per plant. Read More
J Plant Physiol 2018 Nov 4;232:107-114. Epub 2018 Nov 4.
Ruđer Bošković Institute, Bijenička cesta 54, 10000, Zagreb, Croatia. Electronic address:
Although structurally simple, viroids can trigger numerous changes in host plants and cause loss of yield in agronomically important crops. This study investigated changes in the endogenous status of phytohormones and antioxidant enzyme activity in Solanum tuberosum cv. Désirée in response to Potato spindle tuber viroid (PSTVd) infection. Read More
J Plant Physiol 2018 Nov 28;232:100-106. Epub 2018 Nov 28.
ISOPlexis Genebank, University of Madeira, Campus da Penteada, 9020-105, Funchal, Madeira, Portugal.
Taro (Colocasia esculenta L. Schott) is an important staple food crop in tropical and developing countries, having high water requirements. The purpose of this study was to evaluate the feasibility of using carbon and nitrogen isotopic composition (δC and δN) as a physiological indicator of taro response to drought, and elucidation of the relationship between the water use efficiency (WUE) under drought conditions and carbon isotope discrimination (ΔC). Read More
Sci Total Environ 2018 Dec 4;657:96-102. Epub 2018 Dec 4.
Key Lab of Plant-Soil Interaction, Ministry of Education, Center for Resources, Environment and Food Security, College Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address:
Global estimates of soil nitrate leaching of applied nitrogen (N) in agricultural production systems are not imprecise; however, the results of some field experiments have suggested that nitrate leaching responds exponentially rather than linearly to increasing N inputs. In this study, we compiled field data on nitrate leaching for 324 site-year combinations extracted from 86 peer-reviewed articles to test the hypothesis that in response to N fertilizer addition, soil nitrate leaching emission factors (EF) do not remain constant, but rather increase rapidly with increasing rates of N application. The averaged overall results showed that the proportional change in the EF response to increasing N input (ΔEF, %) was 0. Read More
J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.
Oregon Health & Science University, Portland, OR.
Background: The impact of atopic dermatitis (AD) on health related quality of life and health utility in the United States adult population is not well-established.
Objectives: To determine the health utilities and quality of life adjusted years (QALYs) lost in adults with vs. without AD among the US population. Read More
Eur J Pharm Sci 2018 Dec 8. Epub 2018 Dec 8.
Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:
Background: Sirolimus is increasingly investigated as a new targeted therapy in pediatric populations. To date, population pharmacokinetic (PK) studies have identified several factors that explain in part the large between-patient variability in sirolimus PK. However, within-patient variability in sirolimus PK is not well documented. Read More
Appetite 2018 Dec 8. Epub 2018 Dec 8.
Department of Organic Food Quality and Food Culture, Faculty of Organic Agricultural Sciences, University of Kassel, Nordbahnhofstrasse 1A, 37213, Witzenhausen, Germany.
This study aims to investigate consumers' green food purchase intentions using a survey conducted in Qingdao, Shandong Province, China. Based on the Theory of Planned Behavior (TPB), it models the influences of Chinese culture and consumer characteristics towards purchasing green food products. According to TPB, the behavioral intention is determined by attitude, subjective norms and perceived behavioral control, whereas subjective norms vary according to differences in cultural systems. Read More
Food Chem Toxicol 2018 Dec 8. Epub 2018 Dec 8.
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
Neuroscience 2018 Dec 8. Epub 2018 Dec 8.
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, United States. Electronic address:
Dopaminergic signaling in the central nervous system regulates several aspects of animal behavior. In the dopaminergic circuits, there are two classes of neurons that can be differentiated by their expression of dopamine receptors, D1 or D2 receptors (D1Rs or D2Rs). Notably, Ca-permeable GluA2-lacking glutamate AMPA receptors (CP-AMPARs) are important for gating synaptic plasticity and gene expression in neurons, and their expression particularly in the striatum affects various forms of animal behavior. Read More
Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.
Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan. Electronic address:
A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and >90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose. Read More
Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.
Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Department of Biomedical Sciences, Iasi, Romania. Electronic address:
Composites based on combination of biopolymers (chitosan, hyaluronic acid and bovine serum albumin or gelatin), calcium phosphates (CP) and magnetic nanoparticles have been prepared by a biomimetic co-precipitation method. The biomimetic strategy is inspired by natural mineralization processes, where the synthesized minerals are usually combined with proteins, polysaccharides or other mineral forms to form composite, in physiological conditions of temperature and pH. The morphology of the magnetic composites, studied using scanning electron microscopy (SEM) indicated a macroporous structure, which influenced the retention of simulated biological fluids. Read More
Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.
Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:
The aim of this study is to investigate hypolipidemic and antioxidant effects of Pine needle polysaccharide (PNP) from Pinus massoniana in high-fat diet (HFD)-induced mice. PNP could significantly improve the serum lipid levels (total cholesterol, triacylglycerols, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), enhance the antioxidant enzymes levels (total antioxidant capability, superoxide dismutase, glutathione peroxidase, catalase), and decrease malondialdehyde (MDA) content in HFD-induced mice. PNP exhibited distinct antioxidant ability on the superoxide anions, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) in vitro. Read More
Am J Physiol Regul Integr Comp Physiol 2018 Dec 19;315(6):R1254-R1260. Epub 2018 Sep 19.
Foods and Nutrition, University of Georgia , Athens, Georgia.
There is accumulating evidence that the gut microbiota and its composition dynamics play a crucial role in regulating the host physiological functions and behavior. Diet composition is the primary modulator of bacterial richness and abundance in the gastrointestinal (GI) tract. Macronutrient (fat, sugar, and protein) and fiber contents are especially important in determining microbiota composition and its effect on health outcomes and behavior. Read More
Addiction 2019 Jan;114(1):137-138
Department of Psychological Sciences, University of Connecticut, USA.
Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.
Texas A&M University, College Station, Texas.
There are few epidemiologic studies on the shedding of Campylobacter among dogs in the United States, despite the potential public health implications. Our objectives were to estimate the prevalence of faecal Campylobacter shedding among Texas shelter dogs as detected by culture methods and to characterize the isolates by species and antimicrobial susceptibility. Using a cross-sectional study design, faecal samples were collected from 185 dogs in six animal shelters throughout Texas between May and December 2014. Read More
Mol Microbiol 2018 Dec 11. Epub 2018 Dec 11.
School of Microbiology, University College Cork, Cork, Ireland.
The emergence and dissemination of antibiotic resistant bacteria is a major medical challenge. Lantibiotics are highly modified bacterially produced antimicrobial peptides that have attracted considerable interest as alternatives or adjuncts to existing antibiotics. Nisin, the most widely studied and commercially exploited lantibiotic, exhibits high efficacy against many pathogens. Read More
Milbank Q 2018 Dec;96(4):814-857
University of Padua.
Policy Points Policymakers should invest more on researching the long-term health effects of low-ionizing radiation exposure, as we are far from reaching a consensus on a topic that is of enormous importance for public health and safety. Public policies such as those limiting the import of contaminated food from areas hit by a radioactive disaster or those regulating the resident population's access to such areas should follow a precautionary approach. Neoplasm diagnosis and medical care should be designed in order to take into account the possible role of long-term, low-dose radiation exposure. Read More
Mol Plant Pathol 2018 Dec 10. Epub 2018 Dec 10.
Department of Plant Pathology and Microbiology, The Robert H. Smith, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
Many types of yeasts have been studied in the last few years as potential biocontrol agents against different phytopathogenic fungi. Their ability to control plant diseases is mainly through combined modes of action. Among them, antibiosis, competition for nutrients and niches, induction of systemic resistance in plants and mycoparasitism have been the most studied. Read More
Chembiochem 2018 Dec 11. Epub 2018 Dec 11.
Forschungszentrum Julich, Institute of Bio- and Geosciences, Leo-Brandt-Straße, 52425, Juelich, GERMANY.
Phenylpropanoids and phenylpropanoid-derived plant polyphenols find numerous applications in food and pharmaceutical industries. In recent years, several microbial platform organisms were engineered towards producing such compounds. However, for the most part, microbial (poly)phenol production is inspired by nature, and thus predominantly naturally occurring compounds have been produced to this date. Read More
Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.
Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More
Luminescence 2018 Dec 11. Epub 2018 Dec 11.
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El- Aini Street, Cairo, Egypt.
A spectrofluorimetric method for the determination of eptifibatide is presented based on its native fluorescence. The type of solvent and the wavelength of maximum excitation and emission were carefully selected to optimize the experimental conditions. Under the specified experimental conditions, the linearities obtained between the emission intensity and the corresponding concentrations of eptifibatide were in the range 0. Read More
J Sci Food Agric 2018 Dec 10. Epub 2018 Dec 10.
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, No. 29, 13th. Avenue, Tianjin Economic and Technological, Tianjin 300457, China.
Background: The salt tolerant yeast strain C.versatilis usually is added in the high-salt liquid-state soy sauce fermentation. The genome of C. Read More
Plant Biotechnol J 2018 Dec 10. Epub 2018 Dec 10.
Key Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
The CRISPR- Streptococcus pyogenes Cas9 (SpCas9) system offers a rapid, simple and flexible genome editing approach. However, the targeting scope of the SpCas9 system is limited by the canonical NGG PAM. To broaden the editing range of the CRISPR system, several Cas orthologs recognized different PAM were isolated from diverse microbes and were engineered as powerful genome editing tools in eukaryotic cells (Murovec et al. Read More
J Sci Food Agric 2018 Dec 10. Epub 2018 Dec 10.
DIBAF, University of Tuscia, Viterbo, Italy.
Background And Aims: In wine production, the temperature control is important and cooling techniques are frequently used to cool down grape must. Grape compound extraction is facilitated by enzymatic cell wall (CW) disassembly, thus our hypothesis has been that using alternating temperature could favor enzyme activity and, thus, berry compound extraction.
Methods And Results: White wine grapes (cvs 'Falanghina' and 'Fiano') were kept at 4°C or at alternating temperature (4 and 20°C with 6 h interval) for 24 h. Read More
Oral Dis 2018 Dec 7. Epub 2018 Dec 7.
Department of Oral Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Objective: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.
Subjects And Methods: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Read More
Plant J 2018 Dec 8. Epub 2018 Dec 8.
Department of Animal, Plant and Soil Science, School of Life Science, Australian Research Council Centre of Excellence in Plant Energy Biology, La Trobe University, 5 Ring Road, Bundoora, 3086, Victoria, Australia.
Plants respond to short- and long-term mechanical stimuli, via altered transcript abundance and growth respectively. Jasmonate, gibberellic acid and calcium have been implicated in mediating responses to mechanical stimuli. Previously it was shown that the transcript abundance for the outer mitochondrial membrane protein of 66 kDa (OM66), is induced several-fold after 30 min in response to touch. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Department of Nutrition, Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Obesity as a multifactorial disorder has been shown a dramatically growing trend recently. Besides genetic and environmental factors, dysregulation of the endocannabinoid system tone is involved in the pathogenesis of obesity. This study reviewed the potential efficacy of Oleoylethanolamide (OEA) as an endocannabinoid-like compound in the energy homeostasis and appetite control in people with obesity. Read More
New Phytol 2018 Dec 7. Epub 2018 Dec 7.
Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
To deal with the ever-changing environment, sessile plants adapt diverse and plastic organ structures during postembryonic development. Among these, the apical hook forms shortly after seed germination of most dicots, protects the delicate shoot meristem from mechanical damage during soil emergence. For decades, this structure has been taken as an excellent model for investigating the mechanisms underlying differential growth of plant tissues. Read More
J Small Anim Pract 2018 Dec 11. Epub 2018 Dec 11.
Re-Fur-All Referrals, Newbury, Berkshire, UK.
Food intolerance refers to any abnormal physiological response to a food or food additive, believed not to be immunological in nature. Mechanisms include food toxicity, pharmacological reactions, metabolic reactions, dysmotility, dysbiosis, physical effects and non-specific dietary sensitivity. Food intolerance reactions are variable, typically dose-dependent, and can occur at any age. Read More
Mol Nutr Food Res 2018 Dec 11:e1801040. Epub 2018 Dec 11.
J.-H. Kwon, H. G. Lee, K.-H. Seo, H. Kim, Department of Food and Nutrition, Hanyang University, Seoul.
Scope: This study aimed to determine the separate and combined effect of a prebiotic (Catechin-rich wine grape seed flour, GSF) and a probiotic (newly isolated kefir lactic acid bacteria, LAB) on hepatic steatosis of obese mice.
Methods And Results: High-fat (HF)-induced obese mice were fed HF diet containing 6% microcrystalline cellulose (MCC, control), 10% GSF, orally administrated LAB, or combination of GSF and LAB for 9 weeks. There was a significant reduction of body weight gain, and liver weights, plasma insulin concentrations, and HOMA-IR in all experimental groups compared to control. Read More
Pharm Stat 2018 Dec 9. Epub 2018 Dec 9.
Division of Biostatistics, Center for Devices and Radiological Health, Food, and Drug Administration, Silver Spring, Maryland, USA.
Drug developers are required to demonstrate substantial evidence of effectiveness through the conduct of adequate and well-controlled (A&WC) studies to obtain marketing approval of their medicine. What constitutes A&WC is interpreted as the conduct of randomized controlled trials (RCTs). However, these trials are sometimes unfeasible because of their size, duration, and cost. Read More
Nutr Diet 2018 Nov;75(5):445-447
Department of Nutrition, Dietetics and Food, Monash University; Honorary Fellow, Menzies School of Health Research.
Nutr Diet 2018 Nov;75(5):533-540
Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Aim: School nutrition policies can improve healthy food access for Indigenous First Nations children in Canada. This study explored First Nations students' perceptions of a school nutrition policy.
Methods: The research was a process evaluation of school nutrition policy implementation using a mixed-methods design. Read More
Neurogastroenterol Motil 2018 Dec 10:e13523. Epub 2018 Dec 10.
Universidade Estadual de Maringá, Maringá, Brazil.
Background: Toxoplasma gondii infection can occur through the ingestion of raw meat that contains tissue cysts or food that contains oocysts. Through the ingestion of oocysts, the parasite crosses the intestinal barrier, where the enteric nervous system is located. The objective was to investigate the kinetics of neuronal and glial responses during acute T. Read More
J Food Sci 2018 Dec;83(12):2885
J Food Sci 2018 Dec;83(12):2886-2888
J Food Sci 2018 Dec;83(12):2970-2975
Dept. of Biological Sciences and Health, Federal Univ. of Amapa, Rod. Juscelino Kubitschek, Km-02 - Jardim Marco Zero, Macapá-AP, 68903-419, Brazil.
Ellagic acid (EA) has demonstrated several biological properties, such as antioxidant, antimicrobial, and enzymatic inhibition. Zein and chitosan (CHI) are natural polymers whose biological potential has also gained attention. Therefore, this paper aimed to evaluate the antimicrobial, antioxidant, anticollagenase, and antielastase properties of EA, zein, and chitosan isolated or in combination. Read More
J Food Sci 2018 Dec;83(12):2889-2894
Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.
Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.
Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More
Proteins 2018 Dec 11. Epub 2018 Dec 11.
High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India.
The proline-specific M24B peptidases that cleave Xaa-Pro iminopeptide bond in dipeptides are called prolidases while those that preferentially cleave this bond at the N-termini of longer peptides are called aminopeptidases-P. Escherichia coli and other bacteria have small aminopeptidases-P (36-39 kDa) which are considerably diverged from the canonical aminopeptidase-P of E. coli (50 kDa). Read More
J Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.
Evaluation of the effect of food on the pharmacokinetics of oral oncology drugs is critical to drug development, as food can mitigate or exacerbate toxicities and alter systemic exposure. Our aim is to expand on current US Food and Drug Administration (FDA) guidance and provide data-driven food-effect study design recommendations specific to the oncology therapeutic area. Data for recently approved small-molecule oncology drugs was extracted from the clinical pharmacology review in the sponsor's FDA submission package. Read More