1,072,731 results match your criteria Food Chemistry [Journal]


One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Environ Int 2018 Dec 12;123:292-300. Epub 2018 Dec 12.

Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Background: Exposure to inorganic arsenic (iAs) via drinking water is a serious global health threat. Various factors influence susceptibility to iAs-associated health outcomes, including differences in iAs metabolism. Previous studies have shown that obesity is associated with iAs metabolism. Read More

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December 2018
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Detection of norovirus epidemic genotypes in raw sewage using next generation sequencing.

Environ Int 2018 Dec 12;123:282-291. Epub 2018 Dec 12.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.

Noroviruses are a leading cause of epidemic and pandemic acute gastroenteritis (AGE) worldwide, and contaminated food and water are important routes for its transmission. Raw sewage has been used for viral surveillance to monitor the emergence of new norovirus strains with the potential to cause epidemics. In this study, we investigated norovirus occurrence and norovirus RNA levels in 156 samples collected from May 2013 to May 2014, across three different stages (52 samples each) of a wastewater treatment plant (WWTP) in Rio de Janeiro, Brazil. Read More

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December 2018
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The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats.

Biomed Pharmacother 2018 Dec 12;110:667-676. Epub 2018 Dec 12.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, 123, Oman.

We assessed the effect of treatment with the dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups of rats were given either normal food or food mixed with adenine (0.25% w/w for five weeks) to induce CKD. Read More

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December 2018

Detection and quantification of methicillin-resistant Staphylococcus aureus in fresh broiler meat at retail in Germany.

Int J Food Microbiol 2018 Nov 22;292:8-12. Epub 2018 Nov 22.

German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany. Electronic address:

The aim of this study was to detect, to quantify and to characterize MRSA in broiler meat samples with skin. Furthermore, we compared an isolation method using a second selective enrichment step (method A) with a simpler method omitting this step (method B). For quantification we used a direct plating method on selective agar plates and a "Most probable number" (MPN) technique for estimation of low numbers of MRSA. Read More

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November 2018
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Antibacterial properties of nanofibers containing chrysanthemum essential oil and their application as beef packaging.

Int J Food Microbiol 2018 Dec 8;292:21-30. Epub 2018 Dec 8.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

This study was aimed to develop novel antibacterial packaging materials in order to reduce the microbial contamination of food surface. Chrysanthemum essential oil (CHEO) was successfully incorporated into chitosan nanofibers (CS/NF) through electrospinning which was demonstrated by SEM and AFM analysis. The antibacterial mechanism of CHEO against Listeria monocytogenes (L. Read More

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December 2018

Distribution of mycotoxins produced by Penicillium spp. inoculated in apple jam and crème fraiche during chilled storage.

Int J Food Microbiol 2018 Dec 7;292:13-20. Epub 2018 Dec 7.

University of Natural Resources and Life Sciences, Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad-Lorenz-Str. 20, 3430 Tulln, Austria.

Estimations of consumer exposure to mycotoxins through surveillance of mycotoxins in the food trade are well described, but the exposure due to mouldy food in private homes is not known, and may result from removing visible mould on food and eating the rest. In this study, we followed the growth of Penicillium expansum on the surface of apple jam and Penicillium verrucosum on crème fraiche, as well as production and distribution of fungal metabolites throughout the sample (approx. 6 cm high divided into three equal layers), using a multianalyte method, over time (up to 28 days) and at 4, 8 and 15 °C. Read More

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December 2018
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Polyphasic characterization of Epicoccum sorghinum: A tenuazonic acid producer isolated from sorghum grain.

Int J Food Microbiol 2018 Dec 7;292:1-7. Epub 2018 Dec 7.

Laboratory of Mycotoxins and Toxigenic Fungi, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Epicoccum sorghinum isolates from sorghum grain grown in Brazil were characterized using a polyphasic approach based on morphological, genetic and physiologic features. A considerable intraspecific variability was observed. The phylogenetic analysis showed that the 53 isolates studied formed four distinct clades, and their morphological features revealed a high variability in culture. Read More

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December 2018

Overexpression of maize MYB-IF35 increases chilling tolerance in Arabidopsis.

Authors:
Chen Meng Na Sui

Plant Physiol Biochem 2018 Dec 7;135:167-173. Epub 2018 Dec 7.

Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Shandong Normal University, Jinan, 250014, China. Electronic address:

Chilling stress is a critical environmental factor that limits plant growth, yield and distribution. Maize (Zea mays L.) is an important food and forage crop, and industrial raw material, in China. Read More

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December 2018
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Effects of foliar application of zinc sulfate and zinc nanoparticles in coffee (Coffea arabica L.) plants.

Plant Physiol Biochem 2018 Dec 10;135:160-166. Epub 2018 Dec 10.

Department of Horticultural Sciences and Center for Coffee Research & Education, Texas A&M University, TAMU 2133, College Station, TX, 77843, USA.

A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO ‧ HO) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days. Read More

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December 2018
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Study on anti-hyperuricemia effects and active ingredients of traditional Tibetan medicine TongFengTangSan (TFTS) by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

J Pharm Biomed Anal 2018 Nov 17;165:213-223. Epub 2018 Nov 17.

Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Read More

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November 2018

Delignification overmatches hemicellulose removal for improving hydrolysis of wheat straw using the enzyme cocktail from Aspergillus niger.

Bioresour Technol 2018 Dec 10;274:459-467. Epub 2018 Dec 10.

Department of Biology, Lakehead University, Ontario P7B 5E1, Canada. Electronic address:

Based on a general understanding that hemicellulose removal is more efficient than delignification for biomass deconstruction, an Aspergillus niger strain producing high xylanase activity was screened out from seventeen strains by clear halo experiments. Low-cost enzyme cocktail with high xylanase activity was produced from wheat straw medium fermented by the Gyx086 strain. The enzyme cocktail with high xylanase activity could more effectively hydrolyze wheat straw than other biomasses. Read More

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December 2018

Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Biotherapy and Cancer Center and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:

Tannic acid, a hydrolysable tannin, exists commonly in food plants. Tannic acid has already been shown various anticancer mechanisms such as inhibiting the proliferation, inducing a higher apoptotic rate and slowing down the metastasis of different cancers. Moreover, tannic acid was reported to reduce the side effects caused by chemotherapeutics on patients. Read More

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December 2018

Fruit for thought: anaphylaxis to fruit pectin in foods.

J Allergy Clin Immunol Pract 2018 Dec 12. Epub 2018 Dec 12.

Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA.

Clinical Implications: Pectin is a structural heteropolysaccharide previously associated with occupational asthma and only rare accounts of allergy. Few case reports, however, suggest that pectin may contribute to atypical or idiopathic food reactions, particularly in patients with IgE-mediated allergy to tree nuts. Read More

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December 2018

Clinical relevance of enteropathogen co-infections in preschool children - a population-based repeated cross-sectional study.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Objectives: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children.

Methods: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012-October 2014. 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors. Read More

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December 2018

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

Toxicol In Vitro 2018 Dec 12. Epub 2018 Dec 12.

Division of Genetic and Molecular Toxicology, Division of Biochemical Toxicology, National Center for Toxicological Research, U.S Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address:

Many of the toxicants in tobacco smoke undergo biotransformation in the lungs of smokers, both to reactive and to detoxified derivatives. Human air-liquid-interface (ALI) airway tissue models have emerged as an advanced in vitro model for evaluating the toxicity of inhaled substances; however, the metabolic potential of these cultures has not been evaluated extensively. In this study, we compared the metabolic activities of an ALI tissue model to the undifferentiated normal human primary bronchial epithelial (NHBE) cells from which it was derived. Read More

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December 2018
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Modulating the Microbiome: The Future of Allergy Therapeutics?

Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.

The University of Chicago, Department of Pediatrics and Medicine, Chicago, Illinois, United States. Electronic address:

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December 2018
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Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model.

J Pharmacol Toxicol Methods 2018 Dec 12. Epub 2018 Dec 12.

Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address:

Topical ophthalmic drugs are the most commonly used dosage form to treat diseases of the anterior segment of the eye. Although this dosage form has the advantages of ease of application, small volume dose, and rapid action and is largely devoid of systemic adverse effects, the bioavailability is low due to pre-corneal anatomical barriers and the nature of the drug formulation itself. Some complex generic formulations (suspensions, ointments, gels) for topical ophthalmic products face impediments to rapid regulatory approval because of the complex nature of the formulations and difficulties in determining bioequivalence with the innovator product. Read More

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December 2018

In vitro anti-inflammatory and antioxidant potential of thymol loaded bipolymeric (tragacanth gum/chitosan) nanocarrier.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

Department of Bio & Nano Technology, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India. Electronic address:

Thymol is a natural bioactive agent which possesses various medicinal properties like antimicrobial, antifungal, anti-inflammatory, anticancer etc. and has been widely used in traditional medicine and food industries. It is eco-friendly, cheaper, nontoxic and has been granted generally recognized as safe (GRAS) notation by USFDA. Read More

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December 2018

In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

National Wolfberry Engineering Research Center, Yinchuan 750002, People's Republic of China. Electronic address:

In the present study, the digestion under simulated saliva, gastric and small intestinal conditions and in vitro fermentation by human gut microbiota of Lycium barbarum polysaccharides (LBPS) were investigated. As a result, LBPS contained carbohydrates, uronic acids, protein and polyphenols of 60.96 ± 5. Read More

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December 2018
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The effect of different post-exercise beverages with food on ad libitum fluid recovery, nutrient provision, and subsequent athletic performance.

Physiol Behav 2018 Dec 12. Epub 2018 Dec 12.

School of Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia.

This study investigated the effect of consuming either water or a carbohydrate (CHO)-electrolyte sports beverage ('Sports Drink') ad libitum with food during a 4 h post-exercise recovery period on fluid restoration, nutrient provision and subsequent endurance cycling performance. On two occasions, 16 endurance-trained cyclists; 8 male [M] (age: 31 ± 9 y; VO: 54 ± 6 mL·kg·min) and 8 female [F] (age: 33 ± 8 y; VO: 50 ± 7 mL·kg·min); lost 2.3 ± 0. Read More

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December 2018

Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin.

Food Chem Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Departamento de Bioquímica-Instituto de Investigaciones Biomédicas "Alberto Sols", Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas, Madrid, Spain. Electronic address:

Resveratrol is a polyphenol with chemopreventive properties against prostate cancer; however, the mechanisms underlying its actions are not completely understood. Previously, we demonstrated that DUSP1 induces apoptosis in prostate cancer cells; therefore in the present study we investigated the role of this phosphatase on resveratrol effects. Moreover, we analysed the efficiency of combined treatment of resveratrol and the chemotherapeutic drug cisplatin on cellular viability and apoptosis and its relation with DUSP1 in prostate cancer cells. Read More

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December 2018
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Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform.

Swiss Med Wkly 2018 Dec 15;148:w14693. Epub 2018 Dec 15.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Facing multidrug resistant (MDR) bacterial pathogens is one of the most important challenges for our society. The spread of highly virulent and resistant pathogens can be described using molecular typing technologies; in particular, whole genome sequencing (WGS) data can be used for molecular typing purposes with high resolution. WGS data analysis can explain the spatiotemporal patterns of pathogen transmission. Read More

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December 2018
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Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

College of Chinese Medicinal Materials, Jilin Agriculture University, Changchun, China.

Background: In China, Acanthopanax sessiliflorus is a delicious wild vegetable. It is also used to treat of inflammation and pain. Considering that chiisanoside (CSS) is the main constituent of the leaf of A. Read More

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December 2018

Hyperbaric storage at variable room temperature - A new preservation methodology for minced meat compared to refrigeration.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

QOPNA, Departamento de Química, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.

Hyperbaric storage (HS) at variable room temperature (RT) has been proposed as an alternative to refrigeration at atmospheric pressure (RF/AP) for food preservation and scarce information is available regarding HS effect in meat products. In this study the RT/HS effect was evaluated at 100 MPa and variable RT (≈20 °C) for minced meat preservation up to 24 h, initially for one batch, and further two other different batches were independently studied. To assess RT/HS feasibility, microbiological and physicochemical parameters were analyzed, using storage at RF/AP and variable RT/AP (≈20 °C), for comparison. Read More

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December 2018

Feasibility study on direct fermentation of soybean meal by Bacillus stearothermophilus under non-sterile conditions.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212003, China.

Background: To evaluate the feasibility of high-temperature solid-state fermentation using soybean meal (SBM) during the non-sterile process, Bacillus stearothermophilus was employed to assess the nutritional quality and bioactivity of SBM after fermentation.

Results: The fermented SBM (FSBM) without autoclaving showed significant improvements in nutritional quality and bioactivity. The contents of peptides and, crude and soluble proteins increased by 131. Read More

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December 2018
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FDA jeopardizes the lives of lung transplant recipients and in the process severely increases the cost to develop new immunosuppression.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Duke University, Durham, NC, USA.

On January 1, 2018, Medicare Part D insurers implemented a new rule that seriously affects immunosuppression in lung transplant recipients. The program is now following the directive of the US Food and Drug Administration (FDA) that no drug should be dispensed or be covered by insurance for any indications other than those approved by the FDA (1, 2). That excludes the use of mycophenolate (CellCept and Myfortic) and azathioprine (Imuran) for lung transplant recipients. Read More

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December 2018

The variation in hectolitre weight of wheat grain fed with or without enzyme supplementation influences nutrient digestibility and subsequently affects performance in pigs.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 14. Epub 2018 Dec 14.

School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland.

A 2 × 2 factorial experiment was conducted to investigate the effect of feeding a wheat-based diet of two different hectolitre weights (66 vs. 74 kg/hl), achieved through different agronomical conditions, with or without the supplementation of a β-glucanase and β-xylanase enzyme mix on young pigs. The parameter categories which were assessed included growth performance, coefficient of apparent total tract digestibility (CATTD), faecal consistency, faecal microbial populations and faecal volatile fatty acid (VFA) concentrations. Read More

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December 2018

Photoautotrophic synthesis of butyrate by metabolically engineered cyanobacteria.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.

Direct conversion of carbon dioxide into chemicals using engineered autotrophic microorganisms offers a potential solution for both sustainability and carbon mitigation. Butyrate is an important chemical used in various industries, including fragrance, food, and plastics. A model cyanobacterium Synechococcus elongatus PCC 7942 was engineered for the direct photosynthetic conversion of CO to butyrate. Read More

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December 2018

Anatomy of Risk Evaluation and Mitigation Strategies (REMS).

Cancer Treat Res 2019 ;171:93-105

Center for Pharmacoepidemiology and Pharmacoeconomic Research, College of Pharmacy, University of Illinois, Chicago, Illinois, USA.

This Chapter provides an introduction and overview of the U.S. FDA REMS program and applicable regulatory aspects. Read More

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January 2019

The Drug Shortage Crisis in the United States: Impact on Cancer Pharmaceutical Safety.

Cancer Treat Res 2019 ;171:75-92

University of Colorado Denver, Denver, CO, USA.

Drug shortages pose a significant public health concern in the United States, and cancer drugs are among those most affected. Shortages present serious safety risks for patients and substantial burden on providers and the healthcare system. Multifaceted drivers of this complex problem include manufacturing disruptions, raw material shortages, regulatory issues, market dynamics, and limited financial incentives that reward quality and production of off-patent drugs. Read More

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January 2019

Key Elements in Adverse Drug Reactions Safety Signals: Application of Legal Strategies.

Cancer Treat Res 2019 ;171:47-59

University of South Carolina, Columbia, SC, USA.

Adverse drug reactions, or unintended and harmful outcomes related to the administration of a pharmaceutical product, are a major public health concern, particularly for cancer patients. If counted as a separate cause of death, adverse drug reactions would represent the fourth leading cause of death in the United States. Several legal strategies are available to help mitigate their occurrences and to compensate victims for the harm that results from adverse events. Read More

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January 2019
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Consumption of salt rich products: impact of the UK reduced salt campaign.

Int J Health Econ Manag 2018 Dec 14. Epub 2018 Dec 14.

University of Kent, Canterbury, UK.

This paper uses a leading UK supermarket's loyalty card database to assess the effectiveness and impact of the 2004 UK reduced salt campaign. We present an econometric analysis of purchase data to assess the effectiveness of the Food Standard Agency's (FSA) 'reduced salt campaign'. We adopt a general approach to determining structural breaks in the time series of purchase data, using unit root tests whereby structural breaks are endogenously determined from the data. Read More

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December 2018

In vitro characterization of hepatic toxicity of Alternaria toxins.

Mycotoxin Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.

Alternaria mycotoxins are secondary fungal metabolites which can contaminate food and feed. They are produced by Alternaria species with alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA), and tentoxin (TEN) as the main representatives for Alternaria mycotoxins in food. Once passing the intestinal barrier, Alternaria toxins can reach the liver to exert yet uncharacterized molecular effects. Read More

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December 2018
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Cotyledons contribute to plant growth and hybrid vigor in Arabidopsis.

Planta 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Science, University of Technology, Sydney, NSW, 2007, Australia.

Main Conclusion: In hybrids of Arabidopsis, cotyledons influence the amount and proportion of hybrid vigor in total plant growth. We found Arabidopsis cotyledons are essential for plant growth and in some hybrids for hybrid vigor. In hybrids between C24 and Landsberg erecta (Ler), biomass vigor (heterosis) occurs in the first few days after sowing (DAS), with hybrid cotyledons being larger than those of their parents. Read More

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December 2018

Selected Uncommon Legumes as a Source of Essential Fatty Acids, Tocopherols, Tocotrienols, Sterols, Carotenoids, and Squalene.

Plant Foods Hum Nutr 2018 Dec 14. Epub 2018 Dec 14.

School of Studies in Chemistry/Environmental Science, Pt. Ravishankar Shukla University, Raipur, CG, 492010, India.

The seeds of nine species belonging to the Fabaceae family (Cassia alata, Cassia uniflora, Cassia obtusifolia, Cassia tora, Crotalaria albida, Crotalaria juncea, Crotalaria pallida, Indigofera tinctoria, and Tephrosia purpurea) were studied. The oil yield ranged from 2.0 to 9. Read More

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December 2018
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Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide.

Mikrochim Acta 2018 Dec 14;186(1):20. Epub 2018 Dec 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian Blue (type FeO@Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of FeO (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). Read More

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December 2018

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Exposure to environmental chemicals has been shown to have an impact on the epigenome. One example is a known human carcinogen 1,3-butadiene which acts primarily by a genotoxic mechanism, but also disrupts the chromatin structure by altering patterns of cytosine DNA methylation and histone modifications. Sex-specific differences in 1,3-butadiene-induced genotoxicity and carcinogenicity are well established; however, it remains unknown whether 1,3-butadiene-associated epigenetic alterations are also sex dependent. Read More

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December 2018

Systematic review of clinician awareness of mycotoxin impact in neural tube defects and best practices for pediatric neurosurgeons: implications for public health and policy.

Childs Nerv Syst 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Baylor College of Medicine; Division of Pediatric Neurosurgery, Texas Children's Hospital, 6701 Fannin St., Ste. 1230, Houston, TX, 77030, USA.

Purpose: In lower-income populations, high rates of neural tube defects (NTDs) are a concern. Nutritional folate deficiencies and mycotoxins in contaminated food supplies increase risk of NTDs. As physicians in public health and involved in the care of children with NTDs, pediatric neurosurgeons have an interest in the treatment and prevention of NTDs. Read More

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December 2018
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Floral and Foliar Source Affect the Bee Nest Microbial Community.

Microb Ecol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Program in Microbiology, University of California, 900 University Ave., Riverside, CA, 92521, USA.

Managed pollinators such as the alfalfa leafcutting bee, Megachile rotundata, are essential to the production of a wide variety of agricultural crops. These pollinators encounter a diverse array of microbes when foraging for food and nest-building materials on various plants. To test the hypothesis that food and nest-building source affects the composition of the bee-nest microbiome, we exposed M. Read More

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December 2018
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Analysis of Environmental Contaminants in Muskrat Root, Acorus americanus Raf.: A Traditional Indigenous Medicinal Plant.

Bull Environ Contam Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Mi'gmawe'l Tplu'taqnn Incorporated (MTI), 40 MicMac Road, Eel Ground, Miramichi, NB, E1V4B1, Canada.

The diets of Indigenous people rely on food and medicinal plants harvested directly from the land and there is increasing concern from Indigenous knowledge holders over changes to the appearance and flavor of wild harvested food and medicinal plants. We collected samples of muskrat root, considered an important medicinal plant, at 11 traditional collection locations to quantify contaminants of concern. There were no spatial or temporal trends apparent and the risk via consumption was found to be very low. Read More

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December 2018

Niacin, alkaloids and (poly)phenolic compounds in the most widespread Italian capsule-brewed coffees.

Sci Rep 2018 Dec 14;8(1):17874. Epub 2018 Dec 14.

Human Nutrition Unit, Department of Food and Drugs, University of Parma, Parma, Italy.

Coffee is one of the most popular beverages worldwide and, nowadays, one of the most practical way for its preparation is by prepacked capsules. The aim of this study was comparing the content in caffeine, trigonelline, N-methylpyridinium (NMP), niacin, and chlorogenic acids of 65 different capsule-brewed coffees, commercialised by 5 of the most representative brands in Italy. Coffees were prepared from capsules following manufacturer's instructions and analysed with an optimized UHPLC-MS/MS method able to assess all these phytochemicals in one single run. Read More

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December 2018

Essential oils sensory quality and their bioactivity against the mosquito Aedes albopictus.

Sci Rep 2018 Dec 14;8(1):17857. Epub 2018 Dec 14.

Department of Agriculture, Food and Environment - University of Pisa, Pisa, Italy.

Repellents are a main tool to prevent the outbreak of mosquito-borne diseases that represents a threat for millions of people worldwide. Plant-based products are very promising, low-toxic and eco-friendly alternative to synthetic repellents. Here, we performed an olfactory screening of the essential oils (EOs) of Artemisia verlotiorum Lamotte (Asteraceae), Lavandula dentata L. Read More

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December 2018
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The novel EHEC gene asa overlaps the TEGT transporter gene in antisense and is regulated by NaCl and growth phase.

Sci Rep 2018 Dec 14;8(1):17875. Epub 2018 Dec 14.

Lehrstuhl für Mikrobielle Ökologie, Wissenschaftszentrum Weihenstephan, Technische Universität München, Weihenstephaner Berg 3, 85354, Freising, Germany.

Only a few overlapping gene pairs are known in the best-analyzed bacterial model organism Escherichia coli. Automatic annotation programs usually annotate only one out of six reading frames at a locus, allowing only small overlaps between protein-coding sequences. However, both RNAseq and RIBOseq show signals corresponding to non-trivially overlapping reading frames in antisense to annotated genes, which may constitute protein-coding genes. Read More

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December 2018

Microbial patterns in patients with histamine intolerance.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

First Department of Medicine, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, Germany.

Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels. Our aim was to determine the intestinal bacterial composition in patients with proven histamine intolerance in comparison to other food intolerances and healthy controls. Read More

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Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.

BMJ Open 2018 Dec 14;8(12):e022195. Epub 2018 Dec 14.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Introduction: Hyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. Read More

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December 2018
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Molecular characterization of LysPBC2, a novel endolysin harboring a spore binding domain.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul 08826, South Korea

To control a spore-forming human pathogen , we isolated and characterized a novel endolysin, LysPBC2, from a newly isolated phage PBC2. Compared to the narrow host range of phage PBC2, LysPBC2 showed very broad lytic activity against all , , and species tested. In addition to a catalytic domain and a cell wall binding domain, LysPBC2 has a spore binding domain (SBD) partially overlapped with its catalytic domain, which specifically binds to spores but not to vegetative cells of Both immunogold electron microscopy and binding assay indicate that the SBD binds the external region of the spore cortex layer. Read More

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December 2018
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survival duration in manure-amended soils is affected by spatiotemporal, agricultural, and weather factors: a multi-season, multi-site field study in the Mid-Atlantic U.S.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

University of Maryland Eastern Shore Department of Agriculture, Princess Anne, MD.

Untreated biological soil amendments of animal origin (BSAAO), like manure, are commonly used to fertilize soils for growing fruit and vegetable crops, and can contain enteric bacterial foodborne pathogens. Little is known about the comparative longitudinal survival of pathogens in agricultural fields containing different types of BSAAO, and field data may be useful to determine intervals between manure application and harvest of produce intended for human consumption to minimize foodborne illness. This study generated 324 survival profiles from 12 different field trials at three different sites (UMES, PA, BARC) in the Mid-Atlantic U. Read More

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December 2018

The ferredoxin-like protein, FerR, regulates PrbP activity in .

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Microbiology and Cell Science Department, Genetics Institute, Institute of Food and Agricultural Science, University of Florida, Gainesville, Florida, United States

In , PrbP is an important transcriptional accessory protein that regulates gene expression through interactions with the RNA polymerase β-subunit and a specific sequence on the promoter region. The constitutive expression of observed upon chemical inactivation of PrbP/DNA interactions indicated that the expression of was not auto-regulated at the level of transcription. This observation suggested that a modulatory mechanism via protein-protein interactions maybe involved. Read More

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December 2018
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Population genetics and characterization of isolates in western jackdaws and game birds in Finland.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, FI-00014, Finland

Poultry is considered a major reservoir and source of human campylobacteriosis but the roles of environmental reservoirs, including wild birds, have not been assessed in depth. In this study, we isolated and characterized from western jackdaws (n=91, 43%), mallard ducks (n=82, 76%) and pheasants (n=9, 9%). Most of the western jackdaw and mallard duck isolates represented MLST sequence types (STs) that diverged from those previously isolated from human patients and various animal species, whereas all pheasant isolates represented ST-19, a common ST among human patients and other hosts worldwide. Read More

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December 2018

A combination of linalool, vitamin C, and copper synergistically trigger Reactive Oxygen Species, DNA damage and inhibits subsp. serovar Typhi and .

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Chemical Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand 247 667, India.

Inappropriate and disproportionate use of antibiotics is contributing immensely to the development of antibiotic resistance in bacterial species associated with food contamination. Use of natural products in combination can be a potent alternative hurdle strategy to inactivate foodborne pathogens. Here, we explored pro-oxidant properties of essential oil inalool and itamin C in combination with opper (LVC) in combating foodborne pathogens and a subsp. Read More

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December 2018
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