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    Elimination diet and the development of multiple tree-nut allergies.
    Pediatr Res 2017 May 26. Epub 2017 May 26.
    Division of Allergy, Immunology and Rheumatology.
    BACKGROUNDDespite its high prevalence, relatively little is known about the characteristics of patients with multiple tree-nuts allergies.METHODSPatients (n=60, aged 4-15 years), recruited for a multiple food (tree-nuts, peanut, milk, egg, soy, sesame and wheat) oral immunotherapy (OIT) study, filled a questionnaire on their initial allergy evaluation. Medical records were reviewed. Read More

    Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy.
    Clin Exp Allergy 2017 Apr 24. Epub 2017 Apr 24.
    Murdoch Childrens Research Institute, Royal Children's Hospital, Australia.
    Background: Food allergies pose a considerable world-wide public health burden with incidence as high as one in ten in 12-month-old infants. Few food allergy genetic risk variants have yet been identified. The Th2 immune gene IL13 is a highly plausible genetic candidate as it is central to the initiation of IgE class switching in B cells. Read More

    Perceptions and Practices Regarding Atopic Dermatitis: A Survey.
    Pediatr Dermatol 2017 May 25. Epub 2017 May 25.
    Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Parents (N = 392) completed a survey at the Minnesota State Fair in August and September 2015 addressing knowledge regarding the pathogenesis of atopic dermatitis (AD), basic skin care practices, and the perceived role of infection and food allergies in AD. Of participating parents, 82% identified food allergy or sensitivity in AD pathogenesis, whereas only 42% identified bacterial infection as an important factor in AD severity. Participants most often received education on skin health from their pediatrician (49%), followed by Internet-based sources (23%), rather than a dermatologist or pediatric dermatologist. Read More

    Poaceae pollen as the leading aeroallergen worldwide: a review.
    Allergy 2017 May 22. Epub 2017 May 22.
    Department of Botany, Ecology and Plant Physiology, University of Córdoba, Spain.
    The Poaceae family comprises over 12,000 wind-pollinated species which release large amounts of pollen into the atmosphere. Poaceae pollen is currently regarded as the leading airborne biological pollutant and the chief cause of pollen-allergy worldwide. Sensitization rates vary by country, and those variations are reviewed here. Read More

    Successful Treatment of Methicillin Susceptible Staphylococcus aureus Osteomyelitis with Oritavancin.
    Pharmacotherapy 2017 May 23. Epub 2017 May 23.
    Mountainstate Orthopedic Associates, 200 Orthopedic Way, Morgantown, WV, 26505.
    Staphylococcus aureus remains the most common causative pathogen in osteomyelitis. New or alternate therapies are often needed to adequately treat S. aureus infections in patients with drug allergies, treatment failures, or drug interactions. Read More

    Fast Real-Time PCR for the Detection of Crustacean Allergens in Foods.
    Methods Mol Biol 2017 ;1620:163-171
    ANFACO-CECOPESCA, Carretera Colegio Universitario, Nº 16, 36310, Vigo, Spain.
    Crustaceans are one of the most common allergens causing severe food reaction. Hypersensitivity reactions associated with seafood intake are one of the most common food allergies in adults. Crustaceans including shrimps, prawns, crabs, lobster, and crayfish are a common cause of anaphylaxis or hypersensitivity, with shrimps and crabs being the most common causes of allergy. Read More

    Particular characteristics of atopic eczema in tropical environments. The Tropical Environment Control for Chronic Eczema and Molecular Assessment (TECCEMA) cohort study.
    An Bras Dermatol 2017 Mar-Apr;92(2):177-183
    Group of Clinical and Experimental Allergy, Pediatric and Allergy Department, University of Antioquia - Medellín, Colombia.
    Background:: Atopic dermatitis is a prevalent health problem in the world. Allergic sensitization is an important risk factor, but the roles of other factors, inherent in tropic region, are unknown.

    Objective:: A cohort study was designed in a tropical city to investigate molecular and environmental risk factors for eczema, considering as particular features perennial exposure to mites, poor living conditions and others tropical characteristics. Read More

    High protein intake along with paternal part-time employment is associated with higher body fat mass among girls from South China.
    Eur J Nutr 2017 May 23. Epub 2017 May 23.
    Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, No.16, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan, People's Republic of China.
    Purpose: Protein intake has been suggested to be associated with body composition among western children. Our aim was to determine whether protein intake is associated with body composition among Chinese children and to investigate whether parental socioeconomic status modifies these associations.

    Methods: Cross-sectional data were collected from the baseline survey of an ongoing population-based prospective open cohort study conducted in 2013. Read More

    Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.
    JAMA Pediatr 2017 May 22. Epub 2017 May 22.
    Utrecht University, Institue for Risk Assessment Sciences (IRAS), Division of Environmental Epidemiology, Utrecht, Germany.
    Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking.

    Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases. Read More

    Thrombotic responses to coronary stents, bioresorbable scaffolds and the Kounis hypersensitivity-associated acute thrombotic syndrome.
    J Thorac Dis 2017 Apr;9(4):1155-1164
    Department of Cardiology, University of Patras Medical School, Patras, Rion, Achaia, Greece.
    Percutaneous transluminal coronary angioplasty with coronary stent implantation is a life-saving medical procedure that has become, nowadays, the most frequent performed therapeutic procedure in medicine. Plain balloon angioplasty, bare metal stents, first and second generation drug-eluting stents, bioresorbable and bioabsorbable scaffolds have offered diachronically a great advance against coronary artery disease and have enriched our medical armamentarium. Stented areas constitute vulnerable sites for endothelial damage, endothelial dysfunction, flow turbulence, hemorheologic changes, platelet dysfunction, coagulation changes and fibrinolytic disturbances. Read More

    Mechanisms of Tolerance Induction.
    Ann Nutr Metab 2017 19;70 Suppl 2:7-24. Epub 2017 May 19.
    Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, Kravis Children's Hospital, New York, NY, USA.
    Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure. Read More

    Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review.
    Clin Exp Allergy 2017 May 17. Epub 2017 May 17.
    Clinical and Experimental Sciences and Human Development in Health Academic Units, University of Southampton, Southampton, UK.
    Background: It has been proposed that the frequent ingestion of baked hen's egg or cow's milk accelerates the resolution of hen's egg or cow's milk allergy. This practice is being introduced into clinical practice.

    Objective: To systematically review the evidence to determine whether the introduction of baked hen's egg or cow's milk into the diet of children with hen's egg or cow's milk allergies respectively leads to a larger proportion of children outgrowing these allergies than expected. Read More

    Patient-Centered Outcomes in Food Allergy.
    Curr Allergy Asthma Rep 2017 Jun;17(6):39
    Stanford University, Palo Alto, California, USA.
    Purpose Of Review: Food allergy prevalence is increasing very rapidly, causing a significant disease burden. The threat of severe allergic reactions occurring unexpectedly and in settings that are not equipped to recognize and treat anaphylaxis is a constant source of worry for individuals and families with food allergies. Inadequate knowledge and understanding in the community significantly impairs the overall quality of life of these individuals and families. Read More

    The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
    J Allergy Clin Immunol 2017 Apr 25. Epub 2017 Apr 25.
    Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia; Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom. Electronic address:
    Background: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse.

    Objective: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years. Read More

    Lactic acid bacteria-specific induction of CD4(+)Foxp3(+)T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling.
    Sci Rep 2017 May 16;7(1):1987. Epub 2017 May 16.
    Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P.R. China.
    The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09. Read More

    An update on the impact of food allergy on anxiety and quality of life.
    Curr Opin Pediatr 2017 May 13. Epub 2017 May 13.
    aChildren's Hospital at Dartmouth, Lebanon bThe Geisel School of Medicine, Hanover, New Hampshire cWhite River Junction VA Medical Center, White River Junction, Vermont dSeton Hill University, Greensburg Pennsylvania, USA.
    Purpose Of Review: Food allergies have become more common, and management involves dietary avoidance that can impair quality of life. Patients and families must manage the daily risk of anaphylaxis at each meal. The purpose of this review is to describe the impact of food allergies on quality of life and to provide an update on new developments in food allergy management, particularly peanut allergy. Read More

    Effect of dietary mannanoligosaccharide supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs.
    J Anim Sci Technol 2017 11;59:11. Epub 2017 May 11.
    Division of Animal Nutrition, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122 India.
    Background: Use of prebiotics in companion animal nutrition is often considered advantageous over probiotics because of the ease of handling, ability to withstand processing and storage etc. While most of the studies on prebiotic use in dogs have been done with processed food as basal diet, the response in relation to homemade diet feeding is not very well explored.

    Methods: The study was conducted to evaluate the effects of dietary mannanoligosaccharide (MOS) supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs. Read More

    Disappearance of severe oral allergy syndrome following omalizumab treatment.
    Eur Ann Allergy Clin Immunol 2017 May;49(3):143-144
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy. E-mail:
    Summary: The first case of disappearance of apple-induced oral allergy syndrome in a birch pollen-allergic patient following omalizumab treatment is reported. This observation in a case of type 2 food allergy suggests that omalizumab is potentially an effective preventive treatment for patients with severe, type 1 food allergies. Read More

    In-flight allergic emergencies.
    World Allergy Organ J 2017 4;10(1):15. Epub 2017 May 4.
    Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore.
    Allergic and hypersensitivity reactions such as anaphylaxis and asthma exacerbations may occur during air travel. Although the exact incidence of in-flight asthma and allergic emergencies is not known, we have concerns that this subject has not received the attention it warrants. There is a need to provide passengers at risk and airlines with the necessary measures to prevent and manage these emergencies. Read More

    Globule Leukocytes and Other Mast Cells in the Mouse Intestine.
    Vet Pathol 2017 Jan 1:300985817705174. Epub 2017 Jan 1.
    1 Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
    Only 2 major mast cell (MC) subtypes are commonly recognized in the mouse: the large connective tissue mast cells (CTMCs) and the mucosal mast cells (MMCs). Interepithelial mucosal inflammatory cells, most commonly identified as globule leukocytes (GLs), represent a third MC subtype in mice, which we term interepithelial mucosal mast cells (ieMMCs). This term clearly distinguishes ieMMCs from lamina proprial MMCs (lpMMCs) while clearly communicating their common MC lineage. Read More

    Medical certification reduces the number of children requiring allergen elimination diets for school lunches.
    Asia Pac Allergy 2017 Apr 26;7(2):92-96. Epub 2017 Apr 26.
    Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan.
    Background: Following the increase in the number of children with food allergies, support systems are now required for school lunches, but a large-scale factual investigation has not been carried out.

    Objective: We evaluated the features of elimination diet due to food allergy and the support system in kindergartens and schools.

    Methods: A prefecture-based questionnaire survey regarding measures for food allergies in school lunches of all kindergartens, public elementary schools, and public junior high schools (631 facilities) was conducted in Oita Prefecture, Japan. Read More

    Gastroenterology Curriculum in the Canadian Medical School System.
    Can J Gastroenterol Hepatol 2017 6;2017:8538974. Epub 2017 Apr 6.
    Faculty of Dentistry and Medicine, University of Alberta, Edmonton, AB, Canada.
    Background and Purpose. Gastroenterology is a diverse subspecialty that covers a wide array of topics. The preclinical gastroenterology curriculum is often the only formal training that medical students receive prior to becoming residents. Read More

    Allergen-specific IgG antibodies signaling via FcγRIIb promote food tolerance.
    J Allergy Clin Immunol 2017 May 4. Epub 2017 May 4.
    Department of Medicine, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.
    Background: Food-allergic subjects produce high-titer IgE antibodies that bind to mast cells via FcεRI and trigger immediate hypersensitivity reactions upon antigen encounter. Food-specific IgG antibodies arise in the setting of naturally resolving food allergy and accompany the acquisition of food allergen unresponsiveness in oral immunotherapy (OIT).

    Objective: In this study, we sought to delineate the effects of IgG and its inhibitory Fc receptor, FcγRIIb, on both de novo allergen sensitization in naïve animals and on established immune responses in the setting of pre-existing food allergy. Read More

    Skin prick test is more useful than specific IgE for diagnosis of buckwheat allergy: A retrospective cross-sectional study.
    Allergol Int 2017 May 4. Epub 2017 May 4.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
    Background: Buckwheat (BW) is a potentially life-threatening allergen. Usefulness of BW-specific immunoglobulin-E (BW-sIgE) level for diagnosis of BW allergy is controversial, while the skin prick test (SPT) is widely used because of its less invasive procedure and immediate results. However, there are no data comparing usefulness of the SPT and BW-sIgE level. Read More

    Differential representation of albumins and globulins during grain development in durum wheat and its possible functional consequences.
    J Proteomics 2017 May 3. Epub 2017 May 3.
    Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Naples, Italy. Electronic address:
    Durum wheat (Triticum turgidum ssp. durum (Desf.) Husn. Read More

    Allergenic extracts to diagnose and treat sensitivity to insect venoms and inhaled allergens.
    Ann Allergy Asthma Immunol 2017 May;118(5):531-536
    Division of Bacterial, Parasitic and Allergenic Products, US Food and Drug Administration, Silver Spring, Maryland. Electronic address:
    Objective: To review allergenic extracts used to diagnose or treat insect allergies, including how the extracts are manufactured and their measurements of potency or concentration.

    Data Sources: Peer-reviewed articles derived from searching PubMed (National Center for Biotechnology Information) about insect allergies and extract preparation. Encyclopedia of Life (http://www. Read More

    Restaurant-based intervention to facilitate healthy eating choices and the identification of allergenic foods at a family-oriented resort and a campground.
    BMC Public Health 2017 May 5;17(1):393. Epub 2017 May 5.
    Eurecat-Reus, Centre Tecnològic de Catalunya, Avda Universitat 1, 43204, Reus, Spain.
    Background: Restaurant-based interventions can be an enjoyable way to encourage healthier eating choices by all members of a family. Thus, the principal aims of this study were a) to promote healthy diets by increasing healthy food offerings and b) to increase the number of foods offered specifically as gluten-free and lactose-free and to inform patrons by including nutritional and allergen information that complies with Regulation 1169/2011 regarding the food served in restaurants, takeaways and snack bars.

    Methods: A restaurant-based intervention was implemented at 16 food establishments at 2 resorts (the Cambrils Park Resort and Camping Sangulí, Spain, from 2014 to 2015) based on the following 4 components: 1) providing nutritional and allergen analyses of the offered dishes, 2) increasing the number of healthy food choices, 3) identifying menu items associated with allergies and intolerance, and 4) training staff on healthy eating and allergens. Read More

    Recombinant allergy vaccines based on allergen-derived B cell epitopes.
    Immunol Lett 2017 May 1. Epub 2017 May 1.
    Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
    Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensitivity disease. It affects more than 25% of the population. In IgE-sensitized subjects, allergen encounter can causes a variety of symptoms ranging from hayfever (allergic rhinoconjunctivitis) to asthma, skin inflammation, food allergy and severe life-threatening anaphylactic shock. Read More

    Food Allergy in South Africa.
    Curr Allergy Asthma Rep 2017 Jun;17(6):35
    Division of Allergology, Red Cross War Memorial Children's Hospital, Klipfontein Road, Cape Town, 7700, South Africa.
    Purpose Of The Review: Whilst food allergy seems to have increased significantly in many developed countries in the past few decades, quality data on the burden of food allergy in many developing countries is scanty. Until recently, South Africa had a dearth of robustly designed food allergy studies. This article summarizes some of the recent research and observations regarding food allergy from the South African setting. Read More

    Side effects and their impact on the success of milk oral immunotherapy (OIT) in children.
    Int J Immunopathol Pharmacol 2017 Mar 1:394632017697986. Epub 2017 Mar 1.
    1 Allergy Unit, Department of Pediatric, Anna Meyer Children's University Hospital, Florence, Italy.
    Oral immunotherapy (OIT) has been introduced as a new immune-modulating treatment under investigation for food allergies. The aim of our study was to evaluate the success of OIT in a cohort of children with milk allergy. These children underwent OIT in a clinical practice and were followed for up to ten years. Read More

    IgE-mediated food allergies in children: prevalence, triggers, and management.
    Korean J Pediatr 2017 Apr 25;60(4):99-105. Epub 2017 Apr 25.
    Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
    Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. Read More

    Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
    Hypertension 2017 Jun 1;69(6):1156-1164. Epub 2017 May 1.
    From the Department of Obstetrics and Gynecology, Juntendo University, Tokyo, Japan (N.U., S.T.); and Department of Diabetology and Endocrinology (N.U., K.K., M.K., D.K.) and Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute (K.K., D.K.), Kanazawa Medical University, Ishikawa, Japan.
    Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II). Here, we found that COMT deficiency could explain the hypersensitivity of pressor response against Ang II in mice because of the lack of 2-ME-dependent suppression of angiotensin II receptor type 1 (AT1R). Male C57BL/6 mice were subjected to COMT inhibitor (COMTi: 25 mg/kg per day) or oil (control) for 4 weeks, with or without low-dose Ang II infusion (ANGII: 70 ng/kg per minute) for the last 3 weeks. Read More

    Role of Histamine-releasing Factor in Allergic Inflammatory Reactions.
    Yakugaku Zasshi 2017 ;137(5):517-521
    Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences.
     Mast cells are effector cells in immunoglobulin E (IgE)-mediated immediate hypersensitivity and allergic diseases such as asthma and food allergy. Mast cells are activated by the aggregation of the IgE-bound high-affinity IgE receptor FcεRI with multivalent antigen. Activated mast cells secrete proinflammatory mediators such as histamine, serotonin, and proteases and produce cytokines and chemokines. Read More

    Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity.
    Oncotarget 2017 Apr 8. Epub 2017 Apr 8.
    Department of Child and Adolescent Healthcare, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China.
    Calprotectin, also known as S100A8/A9, has been linked to gut inflammation caused by IgE-mediated food hypersensitivities, but the pathophysiologic abnormalities it causes remain to be determined. We created a mild food hypersensitivity model through oral gavage of ovalbumin in Norway brown rats without using immune adjuvant. Changes in the levels of calprotectin and inflammation-associated cytokines were then observed over time. Read More

    Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network.
    Exp Cell Res 2017 Apr 25. Epub 2017 Apr 25.
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Electronic address:
    Benzyl alcohol (BnOH) is widely used as a component of foods, cosmetics, household products and medical products. It is generally considered to be safe for human use, however, it has been connected to a number of adverse effects, including hypersensitivity reactions and neonatal deaths. BnOH is a membrane fluidizing agent that can affect membrane protein activity and cellular processes such as ligand binding to cell surface receptors, endocytosis and degradation of lysosomal cargo. Read More

    Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation.
    Annu Rev Immunol 2017 Apr;35:371-402
    Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; email: , , ,
    Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival. A family of G protein-coupled receptors (GPCRs) termed the metabolite-sensing GPCRs bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. Read More

    Vitamin D and food allergies in children: A systematic review and meta-analysis.
    Allergy Asthma Proc 2017 May;38(3):21-28
    Background: Vitamin D insufficiency has been associated with immune dysfunction and linked to the epidemic of atopic diseases in the Western hemisphere, yet there are studies with conflicting results, and the risk has not been quantified uniformly across studies.

    Objective: To perform a systematic review and meta-analysis to evaluate and quantify if vitamin D deficiency is associated with the presence and persistence of food allergy.

    Methods: A systematic review was undertaken to assess for the association between food allergy and vitamin D status in children. Read More

    Qualitative research in teen experiences living with food-induced anaphylaxis: A meta-aggregation.
    J Adv Nurs 2017 Apr 25. Epub 2017 Apr 25.
    College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
    Aim: To describe the central experiences of teens living with food-induced anaphylaxis as a first step in responding to healthcare needs in this population.

    Background: As prevalence of allergy increases and commonly outgrown allergies persist longer, chronic management for teens becomes increasingly important. Synthesizing existing research helps to recognize management needs specific to teens with food allergy. Read More

    Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities.
    Theranostics 2017 26;7(5):1088-1099. Epub 2017 Feb 26.
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic strategies and tailored treatment options is an unmet need. Read More

    Characterization of bacterial communities of donkey milk by high-throughput sequencing.
    Int J Food Microbiol 2017 Jun 30;251:67-72. Epub 2017 Mar 30.
    Dipartimento di Scienze Veterinarie, Università di Torino, Largo Braccini 2, 10095 Grugliasco, TO, Italy. Electronic address:
    The interest in donkey milk (DM) is growing because of its functional properties and nutritional value, especially for children with allergies and food intolerances. However, most of the available reports of DM microbiota are based on culture-dependent methods to investigate food safety issues and the presence of lactic acid bacteria (LAB). The aim of this study was to determine the composition of DM bacterial communities using a high-throughput sequencing (HTS) approach. Read More

    Restaurant Food Allergy Practices - Six Selected Sites, United States, 2014.
    MMWR Morb Mortal Wkly Rep 2017 Apr 21;66(15):404-407. Epub 2017 Apr 21.
    Food allergies affect an estimated 15 million persons in the United States (1), and are responsible for approximately 30,000 emergency department visits and 150-200 deaths each year (2). Nearly half of reported fatal food allergy reactions over a 13-year period were caused by food from a restaurant or other food service establishment (3). To ascertain the prevalence of food allergy training, training topics, and practices related to food allergies, CDC's Environmental Health Specialists Network (EHS-Net), a collaborative forum of federal agencies and state and local health departments with six sites, interviewed personnel at 278 restaurants. Read More

    A Mini HIP HOP Assay Uncovers a Central Role for Copper and Zinc in the Antifungal Mode of Action of Allicin.
    J Agric Food Chem 2017 May 26;65(18):3659-3664. Epub 2017 Apr 26.
    King's College London , Institute of Pharmaceutical Science, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.
    Garlic contains the organosulfur compound allicin which exhibits potent antifungal activity. Here we demonstrate the use of a highly simplified yeast chemical genetic screen to characterize its mode of action. By screening 24 validated yeast gene deletion "signature" strains for which hypersensitivity is characteristic for common antifungal modes of action, yeast lacking the high affinity Cu(2+) transporter Ctr1 was found to be hypersensitive to allicin. Read More

    Prognostic Accuracy of Clinical Signs and Diagnostic Tests in Cow's Milk Allergy in Newborns.
    Pediatr Neonatol 2017 Mar 27. Epub 2017 Mar 27.
    Division of Pediatrics, Department of Neonatology, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address:
    Background: The aim of the study was to explore the correlation between clinical signs and confirmatory tests for cow's milk allergy (CMA) in the neonatal period and their relation to family history and the occurrence of food allergies in the postneonatal period.

    Methods: The medical documentation of 361 newborns with suspected CMA and exclusion of other comorbidities was analyzed. The correlations between clinical signs and methods to confirm CMA [elevated levels of total immunoglobulin E (IgE) and/or specific IgE for cow's milk, improvement after the introduction of a cow's milk-free diet and positive challenge procedure] were studied. Read More

    Atopic Dermatitis and Comorbidities: Added Value of Comprehensive Dermatoepidemiology.
    J Invest Dermatol 2017 May;137(5):1009-1011
    Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:
    Atopic dermatitis is common and in its severe form is devastating. This chronic inflammatory dermatosis is part of the atopic syndrome, which includes asthma, food allergies, and hay fever and is known to be associated with mental health disorders. In line with psoriasis, several recent observational studies using national survey and linkage data have suggested a link between atopic dermatitis and cardiovascular disease. Read More

    Prevalence and risk factors for wheezing and allergic diseases in preschool children: A perspective from the Mediterranean coast of Turkey.
    Allergol Immunopathol (Madr) 2017 Apr 11. Epub 2017 Apr 11.
    Mersin University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Mersin, Turkey.
    Objectives: The aim of the present study was to determine the prevalence and risk factors of allergic diseases in preschool children from one of the biggest cities in the Mediterranean Region of Turkey.

    Methods: The study population included 396 preschool children attending to urban daycare centres in Mersin. In the first stage, a comprehensive standardised questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC) was employed. Read More

    Common food colorants and allergic reactions in children: Myth or reality?
    Food Chem 2017 Sep 16;230:578-588. Epub 2017 Mar 16.
    Department of Child Health, School of Medicine, University of Ioannina, Ioannina, Greece. Electronic address:
    Various additives, including food colorants (FCs), are used in the food industry to make food appealing to consumers and to add variety. Despite the widespread usage of FCs, adverse reactions related to their consumption, including reactions triggered by immune (immediate and delayed-type hypersensitivity) and non-immune (intolerance) mechanisms, are considered rare. There is a discrepancy between the perception of patients and parents (7. Read More

    Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models.
    World J Gastroenterol 2017 Mar;23(12):2149-2158
    Meng-Yun Liu, Jian-Qiong Huang, He-Ping Wang, Yue-Jie Zheng, Department of Respiratory, Shenzhen Children's Hospital, Shenzhen 518026, China.
    Aim: To determine whether oral administration of Bifidobacterium infantis CGMCC313-2 (B. infantis CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.

    Methods: Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Read More

    Food labeling issues in patients with severe food allergies: solving a hamlet-like doubt.
    Curr Opin Allergy Clin Immunol 2017 Jun;17(3):204-211
    aDepartment of Allergy bHuman Microbiome Unit, Bambino Gesù Children Hospital, Vatican City, Holy See, Rome, Italy.
    Purpose Of Review: We review the laws on labeling in the international community, the difficulties they pose to the food manufacturers to prepare the food labels and the methodologies to determine the concentration of potential allergens in foods.

    Recent Findings: European Food Safety Authority and International Life Sciences Institute Europe are evaluating strategies to identify the threshold level of allergen that can trigger a reaction in individuals. The most used techniques to detect the presence of protein in food are Enzyme-linked immunosorbent assay, polymerase chain reaction and real time polymerase chain reaction. Read More

    Cypress Pollinosis: from Tree to Clinic.
    Clin Rev Allergy Immunol 2017 Apr 11. Epub 2017 Apr 11.
    Armand Trousseau Children Hospital, AP-HP, Biochemistry Department, Allergy and Environment Research team, Paris, France.
    Cypress (Cupressus is a genus within the Cupressaceae family. This family covers all of the Earth's continents except for Antarctica, and it includes about 160 species. Read More

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