27,702 results match your criteria Food Allergies


Involvement of Activation of Mast Cells via IgE Signaling and Epithelial Cell-Derived Cytokines in the Pathogenesis of Pollen Food Allergy Syndrome in a Murine Model.

J Immunol 2021 Jun 14. Epub 2021 Jun 14.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Fukui, Fukui, Japan.

Murine models to elucidate the pathogenesis of pollen food allergy syndrome (PFAS), characterized by oral hypersensitivity symptoms induced by specific foods in patients previously sensitized with a pollen, are lacking. The study aimed to examine PFAS pathogenesis in a novel murine model. Birch pollen-immunized mice were orally administered apple extract, and oral symptoms were evaluated based on oral rubbing frequency following the challenge. Read More

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Nutritional properties and health aspects of pulses and their use in plant-based yogurt alternatives.

Compr Rev Food Sci Food Saf 2021 Jun 14. Epub 2021 Jun 14.

School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.

Plant-based yogurt alternatives are increasing in market value, while dairy yogurt sales are stagnating or even declining. The plant-based yogurt alternatives market is currently dominated by products based on coconut or soy. Coconut-based products especially are often low in protein and high in saturated fat, while soy products raise consumer concerns regarding genetically modified soybeans, and soy allergies are common. Read More

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Apple allergy: Causes and factors influencing fruits allergenic properties-Review.

Clin Transl Allergy 2021 Jun 2;11(4):e12032. Epub 2021 Jun 2.

Department of Pharmacology Wroclaw Medical University Wroclaw Poland.

Background: Apple tree fruits ( ×  Borkh.) are a rich source of nutrients and nutraceuticals and are recommended as a part of the healthy, staple diet. However, apples could be also the cause of allergies including severe reactions. Read More

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Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United Kingdom.

J Vet Intern Med 2021 Jun 11. Epub 2021 Jun 11.

Hill's Pet Nutrition, Inc, Topeka, Kansas 66616, USA.

Background: Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using novel or hydrolysate protein-based foods.

Objective: To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) in a controlled double-masked, multicenter, prospective clinical trial.

Animals: Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Read More

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Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States.

J Vet Intern Med 2021 Jun 11. Epub 2021 Jun 11.

Pet Nutrition Center, Hill's Pet Nutrition, Inc, Topeka, Kansas 66616, USA.

Background: Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using a novel or hydrolysate protein-based food.

Objective: To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) guidelines and in a controlled double-masked, multicenter, prospective clinical trial.

Animals: Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Read More

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The airway as a route of sensitization to peanut: an update to the dual allergen exposure hypothesis.

J Allergy Clin Immunol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC.

Food allergies have increased at an alarming rate over the past two decades, indicating environmental factors are driving disease progression. It has been postulated that sensitization to foods, in particular peanut, occurs through impaired skin. Peanut allergens have been quantified in household dust and may be the culprit source. Read More

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A new approach for activation of the kiwifruit cysteine protease for usage in in-vitro testing.

Mol Biol Rep 2021 Jun 9. Epub 2021 Jun 9.

Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000, Belgrade, Serbia.

Actinidin (Act d 1), a highly abundant cysteine protease from kiwifruit, is one of the major contributors to the development of kiwifruit allergy. Many studies have focused on the optimization of Act d 1 purification and its role in the development of food allergies. Testing on cell culture monolayers is a common step in the elucidation of food allergen sensitization. Read More

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Treatment Approaches to Food Allergy.

Handb Exp Pharmacol 2021 Jun 9. Epub 2021 Jun 9.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hanover, Germany.

IgE-mediated food allergies affect both children and adults and are associated with dramatic decreases in the quality of life. In the majority of cases, food allergens have to be avoided which may be difficult, particularly in patients who suffer from life-threatening symptoms following the ingestion of minimal doses of food allergens. Several novel therapeutic approaches have been studied during the recent past and are summarized in this review. Read More

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Retrospective Study of Clinico-Aetiological Factors of Chronic Urticaria Among Children Attending a Tertiary Care Paediatric Centre in Eastern Province of Sri Lanka.

Cureus 2021 May 4;13(5):e14848. Epub 2021 May 4.

Paediatrics, Paediatric Professorial Unit, Teaching Hospital, Batticaloa, LKA.

Introduction Chronic urticaria is one of the growing problems worldwide and the prevalence is increasing. Around 2% of children have been shown to be affected with chronic urticaria. Objectives To evaluate demographic, clinical and aetiological factors related to chronic urticaria in children and to assess investigations and treatment. Read More

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Otolaryngologists Practice Pattern on Oral Allergy Syndrome.

Allergy Rhinol (Providence) 2021 Jan-Dec;12:21526567211021305. Epub 2021 May 28.

Department of Otolaryngology & Communication, SUNY Upstate Medical University, Syracuse, New York.

Background: Oral allergy syndrome is a unique type of food allergy caused by cross-sensitivity between inhalant allergens and food allergens. Despite its significant prevalence and potentially serious outcome, the knowledge base and practice patterns on OAS are not well known among otolaryngologists. Our study is designed to understand the practice patterns of otolaryngologists in screening, testing, and treating OAS through a web-based survey. Read More

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Lamotrigine and its relationship with Stevens-Johnson syndrome and toxic epidermal necrolysis

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):202-205. Epub 2020 Apr 13.

Secretaría de Salud, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Dermatología, Ciudad de México, México.

Lamotrigine is an antiepileptic drug that has been widely used for epilepsy, as a mood stabilizer (for type 1 bipolar disorder) and in the management of neuropathic pain, it is used both in monotherapy and in complementary therapy. Considered relatively new, approved by the Food and Drug Administration in 1994, its benefits include a greater margin of safety compared to other anticonvulsants. However, although in a lower percentage, it causes severe adverse skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

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Intergenerational Impacts of Maternal Stress on Early Childhood Atopy in Black Americans.

J Pediatr Psychol 2021 Jun 8. Epub 2021 Jun 8.

Department of Psychology, Emory University, USA.

Objective: Black children are disproportionately affected by atopic diseases (i.e., atopic dermatitis, allergic rhinitis, asthma, and food allergies), with health disparities present in early life. Read More

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Vaccines as therapies for food allergies.

Adv Pharmacol 2021 4;91:229-258. Epub 2021 Mar 4.

Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, United States. Electronic address:

Food allergy is a growing public health epidemic with few available treatments beyond allergen avoidance and rescue medications for accidental exposures. A major focus of therapeutic development for food allergies is allergen-specific immunotherapy (AIT) in which patients are exposed to increasing amounts of allergen in controlled dosing to induce desensitization or tolerance. The work of the past few decades has culminated in the recent FDA approval of a peanut product for oral AIT for peanut allergies. Read More

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A case of lymphocytic esophagitis in a woman with multiple allergies.

Allergy Asthma Clin Immunol 2021 Jun 7;17(1):56. Epub 2021 Jun 7.

Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background: Lymphocytic esophagitis is a newly recognized entity of unknown origin. Dysphagia is defined as difficulty swallowing and represents a common symptom in the general population with a prevalence of approximately 20%. Chronic inflammation of the esophageal wall may manifest itself clinically and endoscopically, mimicking inflammation of another origin. Read More

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A Clinical Update: Nonceliac Gluten Sensitivity-Is It Really the Gluten?

J Nurse Pract 2014 Oct 14;10(9):666-673. Epub 2014 Oct 14.

Division of Special Studies in Symptom Management in the College of Nursing at New York University in New York. Bernadette Capili, PhD, NP-C, is an associate director of the division and an assistant professor of nursing. Michelle Chang, MS, is a research associate at the division. Joyce K. Anastasi, PhD, DrNP, FAAN, is the director of the division, an Independence Foundation endowed professor, and director of the Herbs, Nutraceuticals and Supplements Program.

Gluten-free diets are increasing in popularity among consumers and fueling a global market of gluten-free products. A gluten-free diet is the only treatment for celiac disease (CD). However, many patients are self-reporting and suspecting "gluten sensitivity" after gastrointestinal symptoms, such as bloating, abdominal pain, or diarrhea, resolve on a gluten-free diet without formal evaluation testing for food allergies or CD. Read More

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October 2014

Lamotrigine and Stevens-Johnson Syndrome Prevention.

Psychopharmacol Bull 2021 Mar;51(2):96-114

Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Read More

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Accidental Ingestions to Known Allergens by Food Allergic Children and Adolescents.

Pediatr Allergy Immunol 2021 Jun 6. Epub 2021 Jun 6.

University of Colorado School of Medicine, Department of Pediatrics, Section of Allergy and Immunology, Aurora, Colorado, United States of America.

Background: Accidental ingestions (AI) of food allergens in children compared to adolescents with food allergies are poorly characterized. It is suggested that AIs are higher in adolescents than children and that their reactions may be more severe, presumptively due, at least in part, to increased risk taking behavior. We compared reported AIs in children vs. Read More

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Mosquito vector proteins homologous to α1-3 galactosyl transferases of tick vectors in the context of protective immunity against malaria and hypersensitivity to vector bites.

Authors:
Ranjan Ramasamy

Parasit Vectors 2021 Jun 5;14(1):303. Epub 2021 Jun 5.

ID-FISH Technology, 556 Gibraltar Drive, Milpitas, CA95035, USA.

Background: An epitope, Galα1-3Galβ1-4GlcNAc-R, termed α-gal, is present in glycoconjugates of New World monkeys (platyrrhines) and other mammals but not in hominoids and Old World monkeys (catarrhines). The difference is due to the inactivation of α1-3 galactosyl transferase (α1-3 GT) genes in catarrhines. Natural antibodies to α-gal are therefore developed in catarrhines but not platyrrhines and other mammals. Read More

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Influences of non-IgE-mediated cow's milk protein allergy-associated gut microbial dysbiosis on regulatory T cell-mediated intestinal immune tolerance and homeostasis.

Microb Pathog 2021 Jun 2;158:105020. Epub 2021 Jun 2.

Department of Child Health Care, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. Electronic address:

Gut microbial dysbiosis is closely associated with cow's milk protein allergy (CMPA) during infancy. Recent research has highlighted the crucial role of the commensal microbiota-induced intestinal regulatory T (Treg) cell response in the development of oral tolerance and protection against IgE-mediated food allergies. However, the influences of CMPA (particularly non-IgE-mediated CMPA)-associated microbial dysbiosis on Treg cell-mediated intestinal immune tolerance and homeostasis remain poorly characterized. Read More

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Challenge of food allergy testing and avoidance in children with atopic dermatitis.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Atopic dermatitis (AD) is a common presenting complaint by children and their caretakers to their primary care providers. On testing, children with AD frequently exhibit positive food-specific IgE levels in the absence of immediate allergic reactions. Misinterpretation of these false positive tests can lead to unnecessary food avoidance, which can have tremendous psychosocial, economic and nutritional consequences and, in some cases, facilitate the development of an immediate hypersensitivity to the food. Read More

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Seed Storage Proteins, 2S Albumin And 11S Globulin, Associated to Severe Allergic Reactions after Flaxseed Intake.

J Investig Allergol Clin Immunol 2021 Jun 4. Epub 2021 Jun 4.

Department of Biochemistry and Molecular Biology, Chemistry Faculty, Complutense University of Madrid, Madrid, Spain.

Background: Given the increased popularity of flaxseed in meals, several cases of allergy to these seeds have been reported. Little is known about allergens implicated in hypersensitivity reactions to these seeds. The present work aimed to identify the allergens involved in IgE-mediated reactions in five patients with a clinical history of severe systemic symptoms after flaxseed consumption. Read More

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Nutritional Interventions to Prevent the Development of Atopic Diseases: A Focus on Cow's Milk Allergy.

Handb Exp Pharmacol 2021 Jun 4. Epub 2021 Jun 4.

Division of Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of science, Utrecht University, Utrecht, The Netherlands.

In the western world the prevalence of atopic diseases such as food allergies is increasing highly significantly. One of the earliest and most prevalent food allergies occurring in the first year of life is cow's milk allergy. No treatment is available and only avoidance of the cow's milk allergens prevents the occurrence of an allergic reaction. Read More

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Lactiplantibacillus plantarum 22A-3 isolated from pickle suppresses ovalbumin-induced food allergy in BALB/c mice and 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice.

J Biosci Bioeng 2021 May 31. Epub 2021 May 31.

Maruzen Pharmaceuticals Co. Ltd., 1089-8 Sagata, Shinnichi-cho, Fukuyama 729-3102, Japan.

In the previous study, pickle-derived Lactiplantibacillus plantarum 22A-3 (LP22A3) suppressed ear edema in passive cutaneous anaphylaxis by its oral administration. Moreover, LP22A3 treatment directly to RBL-2H3 cells shows no effect on β-hexosaminidase release from RBL-2H3 but inhibited its release using the Caco-2/RBL-2H3 cells co-culture system stimulated with LP22A3 from the apical side. In this study, oral administration of LP22A3 decreased total IgE and ovalbumin (OVA) specific IgE contents in blood of BALB/c mice induced food allergy by OVA. Read More

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Lineage-Specific Chimerism and Outcome After Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency.

J Clin Immunol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pediatrics, Dr. Von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.

Bi-allelic variants in the dedicator of cytokinesis 8 (DOCK8) gene cause a combined immunodeficiency, characterized by recurrent sinopulmonary and skin infections, food allergies, eczema, eosinophilia, and elevated IgE. Long-term outcome is poor given susceptibility to infections, malignancy, and vascular complications. Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment option and has shown promising outcome. Read More

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Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor.

Neurol Ther 2021 Jun 2. Epub 2021 Jun 2.

Island Neurological Associates, Plainview, NY, USA.

Migraine involves brain hypersensitivity with episodic dysfunction triggered by behavioral or physiological stressors. During an acute migraine attack the trigeminal nerve is activated (peripheral sensitization). This leads to central sensitization with activation of the central pathways including the trigeminal nucleus caudalis, the trigemino-thalamic tract, and the thalamus. Read More

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Identification of a Novel Major Allergen in Buckwheat Seeds: Fag t 6.

J Agric Food Chem 2021 Jun 2. Epub 2021 Jun 2.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 1 Tianehu Road, Hefei, Anhui 230036, China.

Buckwheat is one of the five main allergenic foods (eggs, milk, wheat, buckwheat, and peanuts). Oleosin is an important type of allergen in some allergic foods. However, although most diagnostic nut and seed extracts are defatted, some patients with food allergies may have false negative diagnostic results of oleosin . Read More

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Assessing taxane-associated adverse events using the FDA adverse event reporting system database.

Chin Med J (Engl) 2021 Jun 1;134(12):1471-1476. Epub 2021 Jun 1.

Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Background: Taxanes are an essential class of antineoplastic agents used to treat various cancers and are a fundamental cause of hypersensitivity reactions. In addition, other adverse events, such as bone marrow toxicity and peripheral neuropathy, can lead to chemotherapy discontinuation. This study aimed to evaluate the safety of taxanes in the real world. Read More

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Disposable electrochemical microfluidic device for ultrasensitive detection of egg allergen in wine samples.

Talanta 2021 Sep 1;232:122447. Epub 2021 May 1.

Departamento de Química, Universidade Federal de São Carlos, 13565-905, São Carlos, São Paulo, Brazil. Electronic address:

Food allergies have been increasing all over the world. Egg is an important component in the food industries and the second most common cause of food allergy, shortly after milk. In the wine industry, egg white is applied as a fining agent for tannin removal. Read More

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September 2021

Non-Celiac Gluten Sensitivity: An Update.

Medicina (Kaunas) 2021 May 24;57(6). Epub 2021 May 24.

Clinical and Research Laboratory (LACIUS, URS), Department of Chemical, Biological, and Agricultural Sciences (DC-QB), Division of Sciences and Engineering, University of Sonora, Navojoa 85880, Mexico.

Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by the absence of celiac disease and wheat allergy in patients that trigger reproducible symptomatic responses to gluten-containing foods consumption. Due to the lack of sensitive and reproducible biomarkers for NCGS diagnosis, placebo-controlled gluten challenges must be carried out for its diagnosis. The gluten challenges can be either double- or single-blind, for research or clinical practice purposes, respectively. Read More

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