1,070,684 results match your criteria Food Allergies


The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Vitamin D has received attention for its potential to disrupt cancer processes. However, its effect in the treatment of prostate cancer is controversial. This study aimed to assess the effect of vitamin D supplementation on patients with prostate cancer. Read More

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December 2018
3 Reads

High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome.

Cell Physiol Biochem 2018 6;51(5):2041-2051. Epub 2018 Dec 6.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University and Chongqing Clinical Research Center for Geriatrics, Chongqing,

Background/aims: Alarin has been reported to be related with increased food intake and body weight. The relationship of circulating Alarin with insulin resistance or metabolic syndrome (MetS), however, is unknown. This study aimed to investigate the physiological role of Alarin and its association with MetS in humans. Read More

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December 2018
1 Read

Occurrence and levels of micropollutants across environmental and engineered compartments in Austria.

J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More

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December 2018
1 Read

Impairment of the antifibrotic prostaglandin E pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.

Domest Anim Endocrinol 2018 Nov 3;67:1-10. Epub 2018 Nov 3.

Department of Morphology and Function, CIISA- Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Prostaglandin E (PGE) has contradictory effects in many organs. It may have proinflammatory, anti-inflammatory, or anti-fibrotic roles, depending on the type of receptors to which it binds. By signaling through its receptors EP2 and EP4, PGE mediates anti-inflammatory and anti-fibrotic actions. Read More

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November 2018
2 Reads

Effect of a cauliflower (Brassica oleraceae var. Botrytis) leaf powder-enriched diet on performance, carcass and meat characteristics of growing rabbit.

Meat Sci 2018 Nov 19;149:134-140. Epub 2018 Nov 19.

School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.

The aim of this study was to investigate the effect of a cauliflower leaf powder (CLP)-enriched diet on the performance, quality and antioxidative potential of rabbit meat. No significant differences were found for live performance parameters between rabbits fed with standard (SD) and CLP diet. Dietary supplementation influenced the meat traits of rabbits: CLP meat showed significantly lower drip loss after 48 h, cooking loss, and a significantly higher lightness (L*) and redness (a*) values, vitamin A and vitamin E content, and oxidative stability, compared to SD meat. Read More

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November 2018
1 Read

Does exclusive breastfeeding relate to the longer duration of breastfeeding? A prospective cohort study.

Midwifery 2018 Nov 19;69:163-171. Epub 2018 Nov 19.

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Suboptimal breastfeeding contributes to morbidity and mortality in children. Studies in high-income countries (HICs) show that exclusive-breastfeeding (EBF) is associated with longer breastfeeding duration. The aim of this study was to determine whether maternal reports of EBF at six months are associated with longer duration of breastfeeding during the first two years of life in a low and middle-income country (LMIC) setting, and to identify determinants of breastfeeding duration. Read More

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November 2018

Impact of eutrophication on arsenic cycling in freshwaters.

Water Res 2018 Nov 21;150:191-199. Epub 2018 Nov 21.

Key Laboratory of Environmental Nanotechnology and Health Effects, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; Centre of Integrated Water-Energy-Food Studies (iWEF), School of Animal, Rural, and Environmental Sciences, Nottingham Trent University, Brackenhurst Campus, NG25 0QF, UK. Electronic address:

Many arsenic-bearing freshwaters are facing with eutrophication and consequent algae-induced anoxia/hypoxia events. However, arsenic cycling in eutrophic waters and its impact on public health are poorly understood. Laboratory simulation experiments are performed in this study to investigate the effect of algal blooms on the cycling of arsenic in a sediment-water-air system. Read More

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November 2018
4 Reads

Food up-take and reproduction performance of Daphnia magna under the exposure of Bisphenols.

Ecotoxicol Environ Saf 2018 Dec 3;170:47-54. Epub 2018 Dec 3.

Key laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) & School of Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Because the application of Bisphenol A (BPA) was restricted, many substitutes, such as Bisphenol F (BPF) and Bisphenol S (BPS), were developed as BPA substitutes. Therefore, environmental impacts of BPA and its substitutes on aquatic organisms should be concerned, especially their combined toxicity. In this study, the impacts of BPA, BPF, BPS and their mixture on the feeding behavior, reproduction and physiological function of daphnids were synthetically evaluated, involving the duration and mode of exposure. Read More

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December 2018
4 Reads

A perspective on biogenic synthesis of platinum nanoparticles and their biomedical applications.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 19;211:94-99. Epub 2018 Nov 19.

Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Science Campus, Alagappa University, Karaikudi 630003, India. Electronic address:

In recent era, the interest on inorganic nanoparticles is augmenting due to their engrossing and uncanny properties. Among them, platinum nanoparticles (PtNPs) are highly remarkable owing to their intrinsic physicochemical and biological properties making them an effective candidate towards catalytic and biomedical applications. Nevertheless, conventional physical and chemical methodologies of PtNPs synthesis are among the most prevalent protocols to synthesize PtNPs of desired shape and size. Read More

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November 2018
1 Read

Fast sensing of imidacloprid residue in tea using surface-enhanced Raman scattering by comparative multivariate calibration.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 16;211:86-93. Epub 2018 Nov 16.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China.

This study focused on the fabrication of a rapid, highly sensitive and inexpensive technique for the quantification of imidacloprid residue in green tea, based on surface-enhanced Raman scattering (SERS) using highly roughned surface flower shaped silver nanostructure (as SERS substrate) coupled with the chemometrics algorithm. The basic principle of this method is imidacloprid yielded SERS signal after adsorption on Ag-NF under laser excitation by the electromagnetic enhancement and the intensity of the peak is proportional to the concentration ranging from 1.0 × 10 to 1. Read More

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November 2018
2 Reads

Water drop-surface interactions as the basis for the design of anti-fogging surfaces: Theory, practice, and applications trends.

Adv Colloid Interface Sci 2018 Nov 24;263:68-94. Epub 2018 Nov 24.

Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, 1065 Avenue de la médecine, Québec G1V 0A6, Canada; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hôpital St-François d'Assise, 10 rue de l'Espinay, Québec G1L 3L5, Canada. Electronic address:

Glass- and polymer-based materials have become essential in the fabrication of a multitude of elements, including eyeglasses, automobile windshields, bathroom mirrors, greenhouses, and food packages, which unfortunately mist up under typical operating conditions. Far from being an innocuous phenomenon, the formation of minute water drops on the surface is detrimental to their optical properties (e.g. Read More

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November 2018
1 Read

First ethnobotanical inventory and phytochemical analysis of plant species used by indigenous people living in the Maromizaha forest, Madagascar.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Agriculture, Forestry and Food Science, University of Torino, Torino, Italy.

Ethnopharmacological Relevance: Characterized by one of the highest rates of endemism and biodiversity in the world, Madagascar provides a wide variety of medicinal plants, that could represent a potential source of new drugs. The main aim of this study was to investigate the potential medicinal properties of the plant species used by indigenous people in Maromizaha forest and to provide the first ethnobotanical inventory of the area.

Materials And Methods: Data were collected through open semi-structured interviews with local informants, the reported plants were collected and identified to create a specimen herbarium. Read More

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December 2018
6 Reads

Patatin-like lipolytic acyl hydrolases and galactolipid metabolism in marine diatoms of the genus Pseudo-nitzschia.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

CNR-Istituto di Chimica Biomolecolare, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy. Electronic address:

Diatoms are eukaryotic microalgae that play a pivotal role in biological and geochemical marine cycles. These microorganisms are at the basis of the trophic chain and their lipids are essential components (e.g. Read More

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December 2018
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Exploring potential new galactomannan source of Retama reatam seeds for food, cosmetic and pharmaceuticals: Characterization and physical, emulsifying and antidiabetic properties.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Industrial Engineering, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy.

In this study, physicochemical, interfacial and emulsifying properties of Retama reatam and guar galactomannans were comparatively investigated. The results showed that Retama reatam galactomannan is mainly composed of total carbohydrates (95.52%) and lower protein contents (0. Read More

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December 2018

Medium composition optimization, structural characterization, and antioxidant activity of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Beijing Advanced Innovation Centre for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; Institute of Microbiology, Beijing Forestry University, Beijing 100083, China.

To contribute towards effective exploitation and utilization of natural antioxidants, response surface methodology (RSM) was employed to optimize the medium composition for the production of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi (GLEPS). An optimal medium for GLEPS production was gave through Plackett-Burman design, path of steepest ascent, and Box-Behnken design as follows: glucose (59.62 g/L), yeast extract (10. Read More

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December 2018
2 Reads

Influence of alkali treatment on physicochemical, pasting, morphological and structural properties of mango kernel starches derived from Indian cultivars.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, Punjab, India. Electronic address:

Present investigation was aimed to characterize the influence of alkali treatment on physicochemical, pasting, morphological and structural properties of mango kernel starches from three cultivars viz. Safeda, Chausa, Dussheri when treated with 0.1, 0. Read More

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December 2018

Anticoagulant activity of two novel polysaccharides from flowers of Apocynum venetum L.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

National Center for Research and Development of Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China; Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng 475004, China. Electronic address:

Two novel polysaccharides were obtained from flowers of Apocynum venetum L., and named as Vp2a-II and Vp3. Their average molecular weights were 7 kDa and 9 kDa, respectively. Read More

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December 2018
2 Reads

Ammonium persulphate induced synthesis of polymethyl methacrylate grafted sodium alginate composite films with high strength for food packaging.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, PR China; College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, PR China. Electronic address:

The graft copolymerization of methyl methacrylate (MMA) onto alginate was carried out in aqueous media by initiators of ammonium persulphate under a nitrogen gas atmosphere. Then, the grafting of PMMA chains onto the alginate backbone was confirmed through the study of Fourier transform infrared, X-ray diffraction, scanning electron microscopy and H nuclear magnetic resonance spectroscopy. At last, a thin and transparent polymethyl methacrylate grafted alginate film with high strength was obtained by the casting method. Read More

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December 2018
2 Reads

Enhancement of the carbohydrate content in Spirulina by applying CO, thermoelectric fly ashes and reduced nitrogen supply.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Microbiology and Biochemistry, College of Chemistry and Food Engineering, Federal University of Rio Grande, P.O. Box 474, 96203-900, Rio Grande, RS, Brazil. Electronic address:

This study focused on evaluating whether the injection of CO, which is associated with the use of thermoelectric fly ashes and a reduced supply of nitrogen, affects the production of intracellular carbohydrates from Spirulina. For this purpose, the addition of 0.25 g L of NaNO, along with a 10% (v v) of CO injection, a flow rate of 0. Read More

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December 2018
1 Read

In vitro fermentation of O‑acetyl‑arabinoxylan from bamboo shavings by human colonic microbiota.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, PR China.

BSH-1 is an O‑acetyl-arabinoxylan obtained from bamboo shavings. This study investigated its fermentation behavior by human colonic bacteria in vitro. Results showed that BSH-1 remarkably modulated the composition of colonic microbiota, mainly by increasing the growth of potential beneficial genera (i. Read More

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December 2018
3 Reads

Influence of arabic gum on in vitro starch digestibility and noodle-making quality of Segoami.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Food and Nutrition, Hanyang University, Seoul, 04763, Republic of Korea. Electronic address:

The effects of arabic gum on the quality attributes of rice noodles were characterized in terms of physical properties as well as in vitro starch digestibility. Segoami (high amylose rice) was used to develop rice noodle with low predicted glycemic index (pGI). First, the processing condition for Segoami noodle was investigated at different levels of water content (100%-175%) and steaming time (1-5 min). Read More

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December 2018
2 Reads

Pilot-scale isolation and characterization of extracellular polymeric substances (EPS) from cell-free medium of Spirulina sp. LEB-18 cultures under outdoor conditions.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Federal University of Bahia, Salvador, Brazil.

This objective of this work was to monitor the EPS production during the growth of Spirulina sp. LEB-18, evaluate the productivity and to characterize the exopolymers obtained on pilot-scale under outdoor conditions. The production of crude EPS occurred in all phases of biomass growth and was approximately ten folds higher than that biomass concentration of Spirulina sp. Read More

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December 2018

Inhibitory effects of polysaccharide from Diaphragma juglandis fructus on α-amylase and α-d-glucosidase activity, streptozotocin-induced hyperglycemia model, advanced glycation end-products formation, and HO-induced oxidative damage.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, PR China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu 214122, PR China. Electronic address:

In present study, the in vitro and in vivo hemolysis inhibitory, protective effect against reactive oxygen species (ROS) induced oxidative damage in L02 cells, hypoglycemic, and antiglycation activities of DJP-2, a pure polysaccharide fraction from Diaphragma juglandis fructus, were investigated. Results demonstrated that DJP-2 showed remarkable hemolysis inhibitory activity. Pretreatment with DJP-2 markedly weakened the oxidative damage induced by HO in hepatic L02 cells via strengthening the cell viability. Read More

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December 2018

Physicochemical responses and microbiological changes of bream (Megalobrama ambycephala) to pectin based coatings enriched with clove essential oil during refrigeration.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, PR China. Electronic address:

The effectiveness of pectin coatings enriched with clove essential oil (CEO), as new edible coatings were investigated to preserve bream (Megalobrama ambycephala) fillets during refrigeration over a period of 15 days. All samples were analyzed for physicochemical (pH, PV, TBA and TVB-N), microbiological (Total viable count, Psychrophilic bacteria, Lactic acid bacteria, Enterobacteriaceae, Pseudomonas spp., HS producing bacteria) and organoleptic attributes. Read More

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December 2018
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Physicochemical and functional properties of oleaster (Elaeagnus angustifolia L.) polysaccharides extracted under optimal conditions.

Int J Biol Macromol 2018 Dec 3;124:946-954. Epub 2018 Dec 3.

Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, 84156-83111, Iran. Electronic address:

This research aimed to optimize the polysaccharides extraction of oleaster fruit and then to investigate the physicochemical and functional properties of extracted polysaccharides. Temperature, water to dry matter ratio, time, and alcohol ratio were considered as variables. Purity of extracted polysaccharides was considered as the response. Read More

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December 2018

Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death.

Int J Biol Macromol 2018 Dec 3;124:1060-1068. Epub 2018 Dec 3.

Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea. Electronic address:

Colorectal cancer is the third most diagnosed cancer and a leading cause of cancer death. Dissatisfaction with currently available anti-colorectal cancer drugs caused by unwanted side effects and low efficacy necessitates new therapeutic agents. In the present study, a sulfated glucuronorhamnoxylan polysaccharide (named SPS-CF) purified from a green alga Capsosiphon fulvescens was evaluated for its anti-cancer activity in vitro and in vivo against colorectal cancer. Read More

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December 2018
1 Read

Alternate day fasting decreases preference for a calorically dense diet by increasing chow intake and altering meal pattern parameters.

Physiol Behav 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychology, California State University Long Beach, Long Beach, CA 90840, USA. Electronic address:

Alternate day fasting (ADF) is an effective dietary strategy for weight loss in both humans and rats. However, fasting can elicit hyperphagia in rats, particularly upon access to a calorically dense, high-energy (HE) diet. To examine the effects of ADF on HE diet preference, male and female Sprague-Dawley rats were randomly assigned to receive either ad-libitum or alternate day access to both chow and HE food. Read More

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December 2018
1 Read

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 4;124:139-150. Epub 2018 Dec 4.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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December 2018

Bioactivity of soy-based fermented foods: A review.

Biotechnol Adv 2018 Dec 4. Epub 2018 Dec 4.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. Electronic address:

For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, fermented soy milk, Tempeh and soy sauce. Read More

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December 2018
1 Read

Enhancing effects of acute exposure to cannabis smoke on working memory performance.

Neurobiol Learn Mem 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address:

Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how acute exposure to cannabis smoke affects working memory performance in a rat model. Read More

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December 2018
4 Reads

An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs).

Toxicon 2018 Dec 3. Epub 2018 Dec 3.

School of Life Sciences, University of Technology Sydney, PO Box 123, Broadway, NSW, 2000, Australia.

Microcystin-LR (MC-LR) is a potent cyanobacterial toxin responsible for animal and human poisonings worldwide. MC-LR is found in organisms throughout the foodweb, however there is conjecture regarding whether it biomagnifies. Few studies have investigated how MC-LR interacts with lipid membranes, a determinant of biomagnification potential. Read More

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December 2018

Shining Sunlight on Industry Payments in Oral and Maxillofacial Surgery: The Sunshine Act.

J Oral Maxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Assistant Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA.

Purpose: To characterize industry payments to oral and maxillofacial surgeons (OMSs) and to determine the accuracy of the Centers for Medicare and Medicaid Services (CMS) Open Payments Databases.

Materials And Methods: This was a cross-sectional study of the CMS General and Research Payments Databases in 2016 for clinicians categorized as OMSs. General payments include consulting fees, honoraria, gifts, entertainment, food and beverage, travel and education, and others. Read More

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November 2018
1 Read

Inhaled steroids with and without regular salmeterol for asthma: serious adverse events.

Cochrane Database Syst Rev 2018 Dec 3;12:CD006922. Epub 2018 Dec 3.

Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

Background: Epidemiological evidence has suggested a link between use of beta₂-agonists and increased asthma mortality. Much debate has surrounded possible causal links for this association, and whether regular (daily) long-acting beta₂-agonists (LABAs) are safe, particularly when used in combination with inhaled corticosteroids (ICSs). This is an update of a Cochrane Review that now includes data from two large trials including 11,679 adults and 6208 children; both were mandated by the US Food and Drug Administration (FDA). Read More

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December 2018
5 Reads

Anthocyanins from Cornus kousa ethanolic extract attenuate obesity in association with anti-angiogenic activities in 3T3-L1 cells by down-regulating adipogeneses and lipogenesis.

PLoS One 2018 6;13(12):e0208556. Epub 2018 Dec 6.

Department of Biotechnology, Chonnam National University, Dun-Duk Dong, Yeosu, Chonnam, Korea.

Cornus kousa the Korean dogwood has been traditionally used in East Asia as therapeutic traditional medicine however biological activities of Cornus kousa have not been investigated previously. The aim of the present study was to evaluate anti-obesity activities coupled with anti-angiogenic activities of anthocyanins rich fraction of ethanolic leaf extract of Cornus kousa (ELECk) in HUVECs and 3T3- L1 cells. Dried plants leaves were extracted with 70% ethanol and anthocyanin fraction (AnT Fr) was obtained by eluting the ethanolic extract through non-polar macroporous resin and further purification by HPLC. Read More

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December 2018
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Effects of acute exposures of 2,4,6-trinitrotoluene and inorganic lead on the fecal microbiome of the green anole (Anolis carolinensis).

PLoS One 2018 6;13(12):e0208281. Epub 2018 Dec 6.

The Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi, United States of America.

Microbiome studies focused on ecologically relevant vertebrate models like reptiles have been limited. Because of their relatively small home range, fast maturation, and high fecundity, lizards are an excellent reptilian terrestrial indicator species. For this study we used the green anole, Anolis carolinensis, to assess the impact of military relevant contaminants on fecal microbiome composition. Read More

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December 2018
1 Read

Monitoring the elimination of human African trypanosomiasis: Update to 2016.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006890. Epub 2018 Dec 6.

World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland.

Background: Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populations exposed at various levels of risk, and the coverage of surveillance activities. Based on data provided by the National Sleeping Sickness Control Programmes (NSSCP), Non-Governmental Organizations (NGOs) and research institutions-and assembled in the Atlas of HAT-the World Health Organization (WHO) provides here an update to 2016 for these indicators, as well as an analysis of the epidemiological situation. Read More

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December 2018
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Doping in sport - attitude and professional experience among physicians in Poland.

Folia Med Cracov 2018 ;58(3):35-47

Department of Food Chemistry and Nutrition, Faculty of Pharmacy Jagiellonian University Medical College, Kraków; Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Science, Kraków, Poland.

Introduction: The history of using performance-enhancing substances (PES) is long and it goes back to ancient times. At present, PES are employed at all levels of sport competition, starting from Olympic level contestants to individuals recreationally involved in various sports disciplines.

Purpose: e objective of the study was examining the views on doping in sports in a group of physicians, together with evaluating the frequency of their contacts with this phenomenon, in their professional activities. Read More

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January 2018
1 Read

Global Development of Anticancer Therapies for Rare Cancers, Pediatric Cancers, and Molecular Subtypes of Common Cancers.

J Glob Oncol 2018 Dec(4):1-11

H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.

Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More

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December 2018
1 Read

DHA supplementation during prenatal ethanol exposure alters the expression of fetal rat liver genes involved in oxidative stress regulation.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Manitoba, Food and Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown to alleviate these effects by upregulating antioxidant mechanisms in the brain. The liver is the first organ to receive enriched blood after placental transport; therefore, it could be negatively affected by EtOH, but no studies have assessed the effects of DHA on fetal liver. Read More

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December 2018

GHB614 x T304-40 x GHB119 x COT102 Cotton: Protein Expression Analyses of Field Grown Samples.

J Agric Food Chem 2018 Dec 6. Epub 2018 Dec 6.

Food and feed safety assessment is not enhanced by performing protein expression analysis on stacked trait products. The expression levels of six proteins in cotton matrices from four single cotton events and three conventionally stacked trait cotton products are reported. Three proteins were for insect control, two proteins confer herbicide tolerance, and one protein was a transformation selectable marker. Read More

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December 2018
1 Read

Appearance of di- and Tripeptides in Human Plasma after a Protein Meal does not Correlate with PEPT1 Substrate Selectivity.

Mol Nutr Food Res 2018 Dec 6:e1801094. Epub 2018 Dec 6.

F. Rohm, Dr. H. Daniel, Dr. B. Spanier, Nutritional Physiology, Technical University of Munich, Freising, Germany.

Scope: PEPT1 function is well understood, yet little is known about its contribution towards the absorption of dietary amino acids in the form of di- and tripeptides. In the present human study, we investigated changes in plasma concentrations of a representative oligopeptide panel after meat intake.

Methods And Results: Based on an LC-MS/MS method for quantitative analysis of a panel of selected di- and tripeptides in biological samples, we describe the kinetics of plasma changes of peptides derived from a widely accessible dietary protein source. Read More

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December 2018

Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus.

Plant Biotechnol J 2018 Nov 22. Epub 2018 Nov 22.

Centre for Research in Agricultural Genomics (CRAG, CSIC-IRTA-UAB-UB), Cerdanyola del Vallès, Spain.

Fungi that infect plants, animals or humans pose a serious threat to human health and food security. Antifungal proteins (AFPs) secreted by filamentous fungi are promising biomolecules that could be used to develop new antifungal therapies in medicine and agriculture. They are small highly stable proteins with specific potent activity against fungal pathogens. Read More

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November 2018
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Isolation and identification of endogenous RFRP1 and RFRP3 in the mouse hypothalamus.

J Neuroendocrinol 2018 Dec 6:e12668. Epub 2018 Dec 6.

Department of Biological Functions of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Although RFamide-related peptide (RFRP) preproprotein sequence is known in mice, until now the molecular structure of the mature, functional peptides processed from the target precursor molecule has not been determined. In the present study we purified endogenous RFRP1 and RFRP3 peptides from mouse hypothalamic tissue extracts using immunoaffinity column conjugated with specific antibodies against the mouse C-terminus of RFRP-1 and RFRP-3. Employing liquid chromatography coupled with mass spectrometry (LC-MS) we demonstrated, that RFRP1 consists of 15 and RFRP3 of 10 amino acid residues (ANKVPHSAANLPLRF-NH and SHFPSLPQRF-NH , respectively). Read More

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December 2018
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Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg.

Mol Nutr Food Res 2018 Dec 6:e1800985. Epub 2018 Dec 6.

R. Pei, D. A. Martin, J. C. Valdez, J. Liu, B. W. Bolling, University of Wisconsin-Madison, Department of Food Science,, 1605 Linden Dr., Madison, WI, 53706, USA.

Scope: Increased fruit consumption is associated with reduced risk of colitis. We investigated whether the anti-colitic effects of the polyphenol-rich aronia berry (Aronia mitschurinii 'Viking') were mediated through Th17 and Treg.

Methods And Results: Colitis was induced in recombinase activating gene-1 deficient mice injected with syngeneic CD4 CD62L naïve T cells. Read More

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December 2018
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Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

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December 2018
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