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J Int Med Res 2019 Dec 23:300060519886984. Epub 2019 Dec 23.

IInd Department of Gynecology, Lublin Medical University, Lublin, Poland.

Ovarian adult-type granulosa cell tumors are often associated with endometrial hyperplasia or even uterine cancer. Herein, we present a case report of a 65-year-old female patient who had undergone curettage of the uterine cavity several times due to abnormal and irregular uterine bleeding. Owing to recurrent episodes of vaginal bleeding as well as ineffective pharmacological treatment of simple endometrial hyperplasia without atypia, the patient underwent a laparoscopically-assisted vaginal hysterectomy. Read More

Cancer Genomics Proteomics 2018 Jul-Aug;15(4):329-336

Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Krakow, Poland

Background/aim: A common finding in cancer cells is the overexpression of histone deacetylases (HDACs), leading to altered expression and activity of numerous proteins involved in carcinogenesis. Considering that leptin can modulate the levels of HDACs, we hypothesised that leptin receptor antagonists can alter HDAC expression.

Materials And Methods: HDAC expression in cells exposed to leptin and leptin receptor antagonists (SHLA and Lan2) were evaluated in ovarian epithelial (OVCAR-3, CaOV3) and folliculoma (COV434, KGN) cells. Read More

Cancer Chemother Pharmacol 2017 Oct 31;80(4):815-827. Epub 2017 Aug 31.

Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland.

Purpose: There are no data showing a direct correlation between obesity and increased blood leptin levels with folliculoma. Moreover, folliculoma is not the best studied among other ovarian cancer types. We investigated whether oestradiol can modulate ObR expression in some oestrogen-responsive tissues and that leptin exerts its activity not only via the leptin receptor but also through cross talk with other signalling systems. Read More

Przegl Lek 2014 ;71(1):5-9

Introduction: CyberKnife based radiosurgery is increasingly becoming the common treatment modality used. The high precision and tumor tracking of the CyberKnife makes it a useful tool in gynecological oncology.

Aim: The aim of this study was a preliminary evaluation of CyberKnife based radiosurgery effectiveness as a treatment of patients with gynecological malignancies metastases. Read More

Indian J Otolaryngol Head Neck Surg 2010 Jun 24;62(2):195-7. Epub 2010 Sep 24.

Department of ENT, Mahathma Gandhi Medical College and Research Institute, Pondicherry, 607 402 India.

A 12-year-old girl presented to us with a swelling over the lateral surface of the right pinna of 4 years duration. Examination revealed an irregular mass arising from lateral surface of the pinna obscuring the external auditory canal. The lesion was not ulcerated. Read More

J Avian Med Surg 2009 Sep;23(3):214-21

Maryland Zoo, Baltimore, Druid Hill Park, Baltimore, MD 21217, USA.

Neoplasms of the skin are occasionally seen in domestic birds but are uncommon in nondomestic birds. An 8-year-old male hooded merganser (Lophodytes cucullatus) was presented with bilateral axillary ulcerative lesions that improved but did not resolve with empiric antibiotic and antifungal therapy. Skin biopsies were taken, and bilateral feather folliculomas were diagnosed on histopathologic examination. Read More

Ginekol Pol 2008 Jan;79(1):42-6

Katedra i Klinika Ginekologii Onkologicznej i Pielegniarstwa Ginekologicznego UMK w Toruniu.

The granulosa-cell tumor (folliculoma) is a rare type of ovarian neoplasm, accounting for 5% of all cases. It is the most common type of sex cord-stromal tumors, diagnosed in 70% of cases. The granulosa-cell tumor is a hormone active one, originating from granulosa cells which produce estradiol. Read More

Ginekol Pol 2006 Jul;77(7):516-22

Klinika Ginekologii Operacyjnej Akademii Medycznej w Poznaniu.

Objectives: The purpose of the study was to evaluate the helpfulness of sonomorphological index in preoperative diagnosis of ovarian tumours.

Material And Method: 686 patients diagnosed and treated because of adnexal tumours were analyzed. At the admission day the patient underwent an ultrasonographical examination that stated morphology of tumour using the sonomorphological index (SM). Read More

Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 2004 ;10(2):123-6

Department of Endocrinology for Children and Adolescents, Wrocław, Poland.

The authors present the course of puberty in three girls after surgery because of hormonally active ovarian tumours diagnosed and operated at the age of 3, 6 and 9 years, respectively. In the youngest patient with folliculoma ovari chemotherapy was also given, and girl No. 3 with luteinic capsule was treated for one year with decapeptyl because idiopathic precocious puberty was diagnosed. Read More

Eur J Gynaecol Oncol 2004 ;25(4):484-8

2nd Department of Gynecology, University School of Medicine, Lublin, Poland.

It is well recognized that genetic alterations within oncogenes, tumor suppressor genes, DNA mismatch repair and excision repair genes contribute to tumorigenesis within the human ovary. This study was undertaken to screen for the existence of K-ras gene point mutations in paraffin-embedded slides randomly selected from benign and malignant ovarian tumors applying the PCR-RFLP technique. Expression of p21ras was also assessed in 30 primary ovarian adenocarcinomas immunohistochemically. Read More

Med Pregl 1999 Jun-Aug;52(6-8):241-5

Sluzba za zdravstvenu zastitu zena, Zdravstveni centar Dr Gere Istvan, Senta.

Introduction: Authors have investigated the incidence and distribution of hormonally active ovarian tumors in a 30-year surgical material. Out of 552 ovarian tumors, there were 28 hormonally active tumors (5.07%): 18 granulosa cell tumors, 4 thecomas, 2 arrhenoblastomas, 2 malignant v. Read More

Avian Dis 1999 Jul-Sep;43(3):616-21

Department of Pathobiology, University of Connecticut, Storrs 06269-3089, USA.

Proliferative cutaneous lesions are frequently encountered in examination of avian species. Tumors of the skin have been reported in many bird species, although comparatively less is known about the incidence of integumentary neoplasia in nondomesticated species than in production or companion species. An adult male, 9-yr-old, captive-bred barn owl (Tyto alba) was presented for examination of a proliferative skin mass of several months' duration on the left wing. Read More

J Cutan Pathol 1999 Feb;26(2):109

Ginekol Pol 1993 Apr;64(4):169-73

II Kliniki Ginekologii Operacyjnej AM, Lublinie.

DNA methylation level from woman ovarian malignant tissues was investigated by 32P postlabeling of the single nucleotides, separation on TLC with followed autoradiography and Cerenkov counting. Slight differences in DNA methylation extent were found in malignant ovarian tumors as compared to normal myometrium and benign uterine tumor [myomas]. Lowest level of m5dC in relation to C and also in relation to total DNA was found in carcinoma embryonal tissue whereas maximal DNA methylation level was obtained in folliculoma tissue. Read More

Wiad Lek 1986 Mar;39(6):413-6

Vet Pathol 1982 Mar;19(2):204-6

Pediatriia 1978 (1):75-6

Ginekol Pol 1977 Jan;48(1):69-73

Med Cutan Ibero Lat Am 1975 ;3(5):367-70

The authors present a new case of a rare tumor, folliculoma, located in the face of a 57 year old woman. Concerning histogenesis, it appears most likely that Folliculoma represents a nevus developed from primary epithelial germ. Read More

Pediatriia 1974 Aug;0(8):82-3

Arch De Vecchi Anat Patol 1973 Sep;59(1):141-59

Minerva Pediatr 1972 Apr;24(12):479-86

Feldsher Akush 1969 Apr;34(4):42-3

Wiad Lek 1969 Mar;22(6):571-3

Gynecol Obstet (Paris) 1968 Sep-Oct;67(4):457-68

Ginekol Pol 1968 Feb;39(2):233-7

Arch Oftalmol B Aires 1965 Mar;40(3):45-9

Bull Soc Fr Dermatol Syphiligr 1964 May-Jun;71:318-20

Arch Ostet Ginecol 1964 Mar-Apr;69:133-41

Endokrynol Pol 1962 Mar-Apr;13:199-207

Geneeskd Bl 1962 ;50:267-72

Endokrynol Pol 1961 Nov-Dec;12:649-61

Ann Anat Pathol (Paris) 1961 Jul-Sep;6:411-3

Rum Med Rev 1961 ;5:83-6

Arch Dermatol 1960 Jun;81:922-30

Akush Ginekol (Mosk) 1959 Sep-Oct;35:111

Akush Ginekol (Mosk) 1957 Jan-Feb;33(1):111-2

Gynecol Obstet (Paris) 1955 ;54(4):441-51

C R Seances Soc Biol Fil 1953 Feb;147(3-4):202-3

Riv Ostet Ginecol Prat 1952 Dec;34(12):580-7

Riv Anat Patol Oncol 1952 Jan;5(1):21-36

Sem Hop 1951 Jun;27(47):2042-9

Brux Med 1951 Jun;31(23):1223-6

Rev Int Trach 1951 ;28(2):230-3

Srp Arh Celok Lek 1950 Dec;48(12):883-7

J Exp Med 1933 Jan;57(2):229-38

Laboratories of The Rockefeller Institute for Medical Research.

Spontaneous folliculosis of Macacus rhesus monkeys-a type of follicular conjunctivitis associated with marked, local, inflammatory reactions-is apparently a disease sui generis, due to a specific infectious agent. It can be transmitted from monkey to monkey by means of subconjunctival injection of suspensions, and by conjunctival swabbing of the secretions, of affected tissues, or by contact of normal animals with folliculosis monkeys. The agent causing folliculosis has failed in our hands to pass through Berkefeld and Seitz filters, even those of an unusual degree of permeability; and the lesions that it causes show no cellular inclusions suggestive of the action of a virus. Read More