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    Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid.
    BMC Vet Res 2017 Nov 21;13(1):345. Epub 2017 Nov 21.
    Research Centre for Topical Drug Delivery and Toxicology, Department of Pharmacy, Pharmacology & Postgraduate Medicine, University of Hertfordshire, Hatfield, UK.
    Background: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice. Topical therapy with fusidic acid (FA) is an attractive alternative to systemic therapy based on low minimum inhibitory concentrations (MICs, commonly <0.03 mg/l) documented in canine pathogenic staphylococci, including strains of MRSA and MRSP (methicillin-resistant Staphylococcus aureus and S. Read More

    Prevalence of medical adhesive-related skin injury at peripherally inserted central catheter insertion site in oncology patients.
    J Vasc Access 2017 Nov 8. Epub 2017 Nov 8.
    Department of Nursing, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi - China.
    Introduction: The aim of our study was to identify the prevalence and risk factors of medical adhesive-related skin injuries (MARSI) at peripherally inserted central catheters (PICC) insertion site in oncology patients.

    Methods: A cross-sectional observational study lasting two weeks was carried out in four inpatient departments. Skin assessment data and photographs of skin were collected during PICC maintenance. Read More

    Efficacy and Tolerability of a Twice-Daily, Three-Step Men's Skincare Regimen in Improving Overall Skin Quality and Reducing Shave-Related Irritation.
    Skinmed 2017 1;15(5):349-355. Epub 2017 Oct 1.
    Rodan + Fields, San Francisco, CA;
    More men are beginning to take advantage of opportunities to improve the health and appearance of their skin; however, the effectiveness of men's skincare regimens has not been well studied. The authors investigated the efficacy and tolerance of a twice-daily, three-step men's skincare regimen in improving skin appearance and reducing shave-related issues. Twenty-nine men who used a wet-shaving method completed a specific, three-step, twice-daily facial regimen-a Shave Cleanser, a Post-Shave Treatment, and Day Protection-in place of their usual routine for 4 weeks. Read More

    Pityrosporum Folliculitis: A Retrospective Review of 110 Cases.
    J Am Acad Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Dermatology University of Massachusetts Medical School, Worcester, Massachusetts.
    Background: Pityrosporum folliculitis is an under-recognized eruption of the face and upper trunk that may be confused with, or occur simultaneously with, acne vulgaris.

    Objective: We sought to characterize risk factors for Pityrosporum folliculitis, its clinical presentation, and response to treatment.

    Methods: A retrospective chart review was performed on all patients aged 0 to 21 years seen from 2010-2015 with Pityrosporum folliculitis confirmed by potassium hydroxide (KOH) preparation. Read More

    Utility of Gram staining for diagnosis of Malassezia folliculitis.
    J Dermatol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Dermatology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
    Malassezia folliculitis (MalF) mimics acne vulgaris and bacterial folliculitis in clinical presentations. The role of Gram staining in rapid diagnosis of MalF has not been well studied. In our study, 32 patients were included to investigate the utility of Gram staining for MalF diagnosis. Read More

    Erosive Pustular Dermatosis of the Scalp with Urate-Like Crystals.
    Case Rep Dermatol Med 2017 8;2017:1536434. Epub 2017 Oct 8.
    Auckland University of Technology, Auckland 1142, New Zealand.
    Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer. Read More

    [Pityriasis amiantacea and folliculitis decalvans : An unusual manifestation associated with antitumor necrosis factor-α therapy].
    Hautarzt 2017 Dec;68(12):1007-1010
    Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Innsbruck, Anichstr. 35, 6020, Innsbruck, Österreich.
    We report on a 21-year-old woman with a 3-year history of crusts and erosions on her scalp that had appeared after starting treatment with adalimumab due to Crohn's disease. By clinicopathological correlation pityriasis amiantacea with underlying folliculitis decalvans was diagnosed. Topical and systemic antibiotic treatment showed rapid response. Read More

    Autoimmune Progesterone Dermatitis: A Diagnosis to Consider in a Patient With Cyclical Cutaneous Eruptions.
    J Drugs Dermatol 2017 Oct;16(10):1040-1042
    Autoimmune progesterone dermatitis (APD) is a cyclical cutaneous reaction to progesterone, with symptoms that typically begin 3-10 days before the onset of menstrual flow and end 1-2 days into menses. The symptoms vary in severity from barely visible to anaphylaxis, but most often include an eczematous eruption, erythema multiforme, urticaria, folliculitis, and angioedema. This is a rare disorder with only a handful of documented cases. Read More

    Traction alopecia: A neglected entity in 2017.
    Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):644-649
    Department of Dermatology, School of Medicine, Cardiff University, Cardiff, CF, UK.
    Traction alopecia was first described in 1904 but is still a cause of scarring hair loss in young women worldwide. It is unique in being initially a reversible then an irreversible (scarring) form of alopecia. Linked to tightly-pulled hairstyles, it is seen across all races. Read More

    Certolizumab Pegol-Induced Folliculitis-Like Lichenoid Sarcoidosis in a Patient with Rheumatoid Arthritis.
    Case Rep Dermatol 2017 Sep-Dec;9(3):158-163. Epub 2017 Sep 11.
    Department of Dermatology, Asahikawa City Hospital, Asahikawa, Japan.
    Anti-tumor necrosis factor α (TNF-α) biologic agents are used for treating refractory sarcoidosis. However, sarcoidosis-like epithelioid cell granulomas may develop during anti-TNF-α treatment. A 63-year-old man suffering from rheumatoid arthritis was treated with oral methotrexate and methylprednisolone for 4 years. Read More

    An unresponsive progressive pustular and crusting dermatitis with acantholysis in nine cats.
    Vet Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA.
    Background: Between 2000 and 2012, nine cats were examined with a visually distinctive, progressive crusting dermatitis that was poorly responsive to all attempted therapies.

    Objectives: Documentation of clinical and histopathological findings of this disease.

    Animals: Nine privately owned cats. Read More

    Overexpression of NLRP3, NLRC4 and AIM2 inflammasomes and their priming-associated molecules (TLR2, TLR4, Dectin-1, Dectin-2 and NFκB) in Malassezia folliculitis.
    Mycoses 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
    The activation of NLRP3, NLRC4 and AIM2 inflammasomes is pivotal for innate immunity against some pathogenic fungi, but their role in the pathogenesis of Malassezia folliculitis (MF) remains unclear. The objective of the study was to determine the expression of 4 canonical inflammasomes (NLRP1, NLRP3, NLRC4 and AIM2) and their priming-associated molecules (TLR2, TLR4, Dectin-1, Dectin-2 and NFκB) in MF lesion. Expression of NLRP1, NLRP3, NLRC4, AIM2, caspase-1, IL-1β, TLR2, TLR4, Dectin-1, Dectin-2 and NFκB was detected by immunohistochemistry in skin lesion of 23 MF patients and normal skin of 12 healthy subjects. Read More

    Lipid Metabolic Versatility in Malassezia spp. Yeasts Studied through Metabolic Modeling.
    Front Microbiol 2017 14;8:1772. Epub 2017 Sep 14.
    Department of Biological Sciences, Universidad de los AndesBogotá, Colombia.
    Malassezia species are lipophilic and lipid-dependent yeasts belonging to the human and animal microbiota. Typically, they are isolated from regions rich in sebaceous glands. They have been associated with dermatological diseases such as seborrheic dermatitis, pityriasis versicolor, atopic dermatitis, and folliculitis. Read More

    Systemic photodynamic therapy in folliculitis decalvans.
    Clin Exp Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Clinical Oncology, The Christie NHS Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Folliculitis decalvans (FD) is classified as a primary neutrophilic cicatricial alopecia, and is estimated to account for approximately 10% of all cases of primary cicatricial alopecia. The role of dysfunctional immune activity and the presence of bacteria, particularly Staphylococcus aureus, appear pivotal. We describe a 26-year-old man with a 4-year history of FD that was recalcitrant to numerous systemic and topical therapies, whose disease was virtually cleared during a follow-up of 25 months following a course of treatment with systemic photodynamic therapy (PDT) using ultraviolet light (100-140 J/cm2 ) with porfimer sodium 1 mg/kg as monotherapy. Read More


    [Acute skin infections and their imitators in children : A photo quiz].
    Hautarzt 2017 Oct;68(10):774-783
    Abteilung pädiatrische Dermatologie, Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032, Zürich, Schweiz.
    Background: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. Read More

    Disseminate recurrent folliculitis as the presenting picture of hidradenitis suppurativa.
    Ann Dermatol Venereol 2017 Nov 31;144(11):715-718. Epub 2017 Aug 31.
    11, chaussée de la Muette, 75016 Paris, France. Electronic address:
    Background: Hidradenitis suppurativa (HS) has a polymorphous clinical presentation. Herein we report two cases of HS revealed by disseminate recurrent folliculitis. PATIENTS AND METHODS CASE 1: A 31-year-old woman consulted for disseminate recurrent folliculitis on the trunk and proximal segments of the limbs that had been ongoing for several years. Read More

    Necrotizing Infundibular Crystalline Folliculitis: An Unusual Clinical Presentation and Demonstration of the Presence of Calcium Palmitate.
    Am J Dermatopathol 2017 Aug 8. Epub 2017 Aug 8.
    *Department of Pathology, Necker-Enfants Malades Hospital, APHP, Paris, France; †Cabinet de Dermatologie, Guyancourt, France; ‡Laboratoire des Lithiases, Service des Explorations Fonctionnelles, Tenon Hospital, APHP, Paris, France; and §Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
    Necrotizing infundibular crystalline folliculitis (NICF) is a rare disorder, which was described for the first time by Lucke et al in 1999. NICF is characterized by multiple folliculocentric papules with a predilection for occurring in seborrheic areas in adults and corresponding dilated follicular ostia containing crystalline material. The precise pathogenesis and nature of this crystalline material are currently unknown. Read More

    Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection.
    Antimicrob Agents Chemother 2017 Nov 24;61(11). Epub 2017 Oct 24.
    Department of Microbiology/Immunology, Northwestern University, Chicago, Illinois, USA
    Pseudomonas aeruginosa is a leading cause of intra-abdominal infections, wound infections, and community-acquired folliculitis, each of which may involve macro- or microabscess formation. The rising incidence of multidrug resistance among P. aeruginosa isolates has increased both the economic burden and the morbidity and mortality associated with P. Read More

    Marked improvement in gastric involvement in Behçet's disease with adalimumab treatment.
    Turk J Gastroenterol 2017 Sep 9;28(5):405-407. Epub 2017 Aug 9.
    Department of Gastroenterology, Oita University, Yufu, Japan.
    Gastric involvement is the least frequent manifestation of Behçet's disease, and effective treatment for it unknown. Here the case of a patient with gastric involvement in Behçet's disease that was markedly improved with adalimumab therapy is presented. A 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. Read More

    [Pseudomonas aeruginosa in dermatology].
    Ann Dermatol Venereol 2017 Nov 2;144(11):666-675. Epub 2017 Aug 2.
    Service de dermatologie, hôpital d'instruction des armées Sainte-Anne, 83800 Toulon, France. Electronic address:
    Pseudomonas aeruginosa, a ubiquitous Gram-negative bacillus characterized by its greenish color and sweetish smell, is at the origin of potentially severe forms of dermatosis, such as ecthyma gangrenosum which marks immunosuppression or reveals blood-poisoning, especially in children. It frequently colonizes chronic wounds and serious burns, and spongiotic or acantholytic dermatosis, especially when severe or localized in skinfolds. It requires special care because of its high resistance to antibiotics and antiseptics. Read More

    Skin and soft tissue infections, active component, U.S. Armed Forces, 2013-2016.
    MSMR 2017 Jul;24(7):2-11
    During the 4-year surveillance period, there were 282,571 incident cases of skin and soft tissue infection (SSTI) among active component U.S. military members diagnosed in inpatient or outpatient settings, corresponding to an overall incidence of 558. Read More

    Acne keloidalis nuchae: risk factors and associated disorders - a retrospective study.
    Int J Dermatol 2017 Aug 30;56(8):828-832. Epub 2017 Jun 30.
    Department of Medicine, University of the West Indies, Kingston 7, Jamaica.
    Background: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN. Read More

    Demodex folliculitis.
    CMAJ 2017 06;189(25):E865
    Service de Médecine Interne (Bachmeyer), Hôpital Tenon (AP-HP), Paris, France; Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris) (Moreno-Sabater), Paris, France; and Service de Parasitologie-Mycologie (Moreno-Sabater), Hôpital Saint-Antoine (AP-HP), Paris, France.

    Tumor necrosis factor-induced alopecia: alternative pathology and therapy.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, University of California San Diego, La Jolla, CA.
    Tumor necrosis factor (TNF) inhibitors are used to treat Crohn disease and psoriasis. Although they are typically well tolerated, adverse effects include the development of alopecia, and paradoxically, psoriatic lesions. We recently described a woman with Crohn disease who developed alopecia and scalp psoriasis during infliximab therapy. Read More

    [Tinea barbae profunda due to Trichophyton mentagrophytes after journey to Thailand : Case report and review].
    Hautarzt 2017 Aug;68(8):639-648
    Labor für medizinische Mikrobiologie, Partnerschaft Prof. Dr. med. Pietro Nenoff & Dr. med. Constanze Krüger, Mölbiser Hauptstr. 8, 04571, Rötha/OT Mölbis, Deutschland.
    Tinea barbae represents a very rare dermatophytosis. We report on a tinea barbae profunda following a journey to Southeast Asia. After travel to Thailand, a businessman was affected by a foudroyant proceeding abscessing infection of the upper lip and beard area. Read More

    Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases.
    Case Rep Dermatol 2017 May-Aug;9(2):19-25. Epub 2017 May 22.
    Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
    Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. Read More

    Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
    J Cosmet Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, 'Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. Read More

    Birt-Hogg-Dubé Syndrome - report of two cases with two new mutations.
    J Dermatol Case Rep 2017 Mar 31;11(1):12-15. Epub 2017 Mar 31.
    Dermatology Department of Hospital de Santarém EPE, Santarém, Portugal.
    Introduction: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by cutaneous fibrofolliculomas and/or trichodiscomas, lung cysts, spontaneous pneumothorax and renal tumors. However, its clinical expression is highly variable. This syndrome is caused by germline mutations in the folliculin gene (FLCN) on chromosome 17p11. Read More

    Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study.
    Eur J Dermatol 2017 Jun;27(3):266-270
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. Read More

    IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease.
    Gastroenterology Res 2017 Apr 19;10(2):65-69. Epub 2017 Apr 19.
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
    Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the pathogenesis of VEO-IBD, including interleukin 10 (IL-10) and IL-10 receptor (IL-10R) mutations. In this article, we reviewed the features of and effective therapeutic options for VEO-IBD with IL-10 and/or IL-10R mutations. Read More

    Extreme Phenotype of Epidermal Growth Factor Receptor Inhibitor-induced Destructive Folliculitis.
    Int J Trichology 2016 Oct-Dec;8(4):176-179
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    Due to the increasingly widespread use and side effect profile of epidermal growth factor receptor inhibitors (EGFRIs), cutaneous side effects of these drugs are frequently encountered. The EGFR is expressed on keratinocytes and fibroblasts. Inhibition of EGFR can produce a range of cutaneous adverse effects, the most frequent being a characteristic acneiform skin eruption. Read More

    Imatinib mesylate-induced lichenoid drug eruption.
    Cutis 2017 Mar;99(3):189-192
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.
    Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Oct 11;37(7):840-848. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    Retrospective evaluation of concomitant cetuximab and radiotherapy tolerance for locoregional advanced head and neck squamous cell carcinoma treatment in patients unfit for platinum-based chemotherapy.
    Eur Arch Otorhinolaryngol 2017 Jul 5;274(7):2883-2889. Epub 2017 Apr 5.
    Department of Radiotherapy, Head and Neck Unit, Centre François Baclesse, 14000, Caen, France.
    Radiotherapy associated with cetuximab (Cet-RT) is an alternative treatment to platinum-based chemoradiotherapy in locally advanced head and neck carcinoma (LAHNC). Reviews suggest that the use of cetuximab is associated with poorer tolerance in patients unfit for chemotherapy than in pivotal trial. We retrospectively studied patients first treated by Cet-RT for LAHNC presenting contraindications to chemoradiotherapy. Read More

    Review in peeling complications.
    J Cosmet Dermatol 2017 Sep 27;16(3):319-326. Epub 2017 Mar 27.
    Department of Dermatology, HUB, University of Brasilia, Brasilia, Brazil.
    Chemical peeling, a procedure wherein a chemical agent is applied to the skin to cause controlled destruction followed by regeneration and remodeling, is a dynamic tool for the treatment of acne, pigmentation issues, and photoaging [Journal of cutaneous and aesthetic surgery vol. 5 (2012) 254-260]. The results and complications are related to the depth of the procedure, with deeper peels producing more marked results and higher rates of complications. Read More

    Lichenoid folliculitis: A unifying concept.
    J Cutan Pathol 2017 Mar 26. Epub 2017 Mar 26.
    Department of Dermatology, Uniformed Services University of the Health Sciences, Los Angeles, Maryland.
    Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution). An interface dermatitis with lichenoid inflammation is characteristic of the LPP group of disorders, but the literature provides scant information about the histopathology of the KPA group. Read More

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