327 results match your criteria Follicular Infundibulum Tumor


Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

Tumor of follicular infundibulum-associated neoplasms.

JAAD Case Rep 2019 Jan 4;5(1):15-18. Epub 2018 Dec 4.

Department Of Dermatology, Penn State Milton S. Hershey Medical Center.

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http://dx.doi.org/10.1016/j.jdcr.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282444PMC
January 2019
1 Read

Activin A in Mammalian Physiology.

Physiol Rev 2019 01;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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http://dx.doi.org/10.1152/physrev.00002.2018DOI Listing
January 2019
6 Reads
27.324 Impact Factor

Inflammation and LPS-Binding Protein Enable the Stimulatory Effect of Endotoxin on Prolactin Secretion in the Ovine Anterior Pituitary: Ex Vivo Study.

Mediators Inflamm 2018 14;2018:5427089. Epub 2018 Aug 14.

Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.

Prolactin is a hormone that plays an important role in the regulation of many physiological processes including lactation, reproduction, fat metabolism, and immune response. The secretion of prolactin could be disturbed by an immune stress commonly accompanying infection. This study was designed to determine the influence of bacterial endotoxin-lipopolysaccharide (LPS)-on prolactin gene (PRL) expression and prolactin release from the ovine anterior pituitary (AP) explants collected from saline- and LPS-treated ewes in the follicular phase. Read More

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http://dx.doi.org/10.1155/2018/5427089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112077PMC
December 2018
1 Read

Eruptive tumors of the follicular infundibulum in photo-exposed skin.

JAAD Case Rep 2018 May 31;4(4):330-332. Epub 2018 Mar 31.

Division of Dermatology, Washington University in St. Louis, St. Louis, Missouri.

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http://dx.doi.org/10.1016/j.jdcr.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911941PMC
May 2018
7 Reads

The Spectrum of Thyroid Gland Pathology in Carney Complex: The Importance of Follicular Carcinoma.

Am J Surg Pathol 2018 05;42(5):587-594

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.

The initial description of Carney complex (CNC) in 1985 included myxomas, spotty skin pigmentation, and endocrine overactivity (of the adrenal, the pituitary, and the testis). In 1997, thyroid neoplasms were found in 3 patients with CNC and involvement of the gland in the syndrome was apparent. Herein, we describe the clinical, pathologic, and follow-up findings in 26 patients with CNC and a disorder of the thyroid gland. Read More

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http://Insights.ovid.com/crossref?an=00000478-900000000-9796
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http://dx.doi.org/10.1097/PAS.0000000000000975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925749PMC
May 2018
5 Reads

Occurrence of Endocrine and Thyroid Cancers Among Alaska Native People, 1969-2013.

Thyroid 2018 04 19;28(4):481-487. Epub 2018 Mar 19.

2 Department of Internal Medicine, Alaska Native Medical Center , Anchorage, Alaska.

Background: Nationwide, the incidence of thyroid cancer is lower among American Indian/Alaska Native (AI/AN) people than among U.S. whites (USW). Read More

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http://dx.doi.org/10.1089/thy.2017.0408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905418PMC
April 2018
45 Reads

Two cases of infundibular squamous cell carcinoma on the nose with aggressive clinical behavior: Case report and review of the published work.

J Dermatol 2018 Feb 15;45(2):220-223. Epub 2017 Nov 15.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

Case 1 was a 75-year-old Japanese man who presented with a poorly demarcated, dark-red nodule with a destructive defect in the center, measuring 3 cm × 2 cm on the right wing of his nose. The histological diagnosis was a common form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the wall of a follicular infundibulum. Read More

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http://dx.doi.org/10.1111/1346-8138.14131DOI Listing
February 2018
11 Reads

Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats.

Arch Gynecol Obstet 2017 Nov 5;296(5):957-963. Epub 2017 Sep 5.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of the reproductive system characterized by polycystic ovaries and androgen excess. Letrozole is a nonsteroidal aromatase inhibitor that is used in experimental research to induce PCOS. Kisspeptin is an essential protein in regulation of cyclicity. Read More

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http://dx.doi.org/10.1007/s00404-017-4509-3DOI Listing
November 2017
35 Reads
1.279 Impact Factor

Warty (follicular) dyskeratoma on the mons pubis.

Authors:
P E Kerr M J Murphy

Int J Womens Dermatol 2017 Sep 26;3(3):154-156. Epub 2017 Jul 26.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.

Warty (follicular) dyskeratoma (WD) is a discrete nodular lesion that demonstrates the characteristic histopathologic findings of acantholysis and dyskeratosis. WDs most commonly occur on the head and neck of adults. We present a case of WD that occurred on the mons pubis of a 53-year-old woman. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555285PMC
September 2017
6 Reads

Ovarian steroids, oxytocin, and tumor necrosis factor modulate equine oviduct function.

Domest Anim Endocrinol 2017 10 24;61:84-99. Epub 2017 Jun 24.

C.I.I.S.A., Faculty of Veterinary Medicine, University of Lisbon, Portugal. Electronic address:

The oviduct plays important roles in the early reproductive process. The aim of this study was to evaluate gene transcription and protein expression of progesterone receptor (PGR), estrogen receptors 1 (ESR1) and 2 (ESR2); oxytocin receptor (OXTR); prostaglandin F2α synthase (AKR1C3), and prostaglandin E2 synthase (Ptges) in mare oviduct in different estrous cycle stages. Estradiol (E), progesterone (P), oxytocin (OXT), and tumor necrosis factor α (TNF) effect on in vitro PGE and prostaglandin F2α (PGF) secretion by equine oviduct explants or by oviductal epithelial cells (OECs) were also assessed. Read More

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http://dx.doi.org/10.1016/j.domaniend.2017.06.005DOI Listing
October 2017
5 Reads

Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds.

Res Vet Sci 2017 Oct 11;114:313-321. Epub 2017 Jun 11.

Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Switzerland.

The goal of this in situ hybridization and image analysis technique is to study the effects of new pharmacological/chemical entities on the thyroid and pituitary gland in rats, reveal the pathogenesis of thyroid follicular cell hypertrophy and to retrospectively exclude the risk of thyroid tumor development in humans. In the present study, we describe the increase of thyroid-stimulating hormone- (TSH-) beta subunit mRNA in the pars distalis of the pituitary gland and the quantitative measurement of TSH mRNA positive cells from rats of three 4-week toxicity studies treated with three different test compounds inducing thyroid follicular cell and hepatocellular hypertrophy in rats. Compared to immunohistochemistry (IHC), in situ hybridization (ISH) for TSH was found to be more sensitive. Read More

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http://dx.doi.org/10.1016/j.rvsc.2017.06.007DOI Listing
October 2017
9 Reads

Keratoacanthoma of the lip: A case report with emphasis on histogenesis.

J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):115-118

Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.

Keratoacanthoma (KA) is a benign epithelial tumor which presents clinically as a proliferating dome-shaped keratin-filled crater. The lesion occurs predominantly upon sun-exposed areas of the body and is known to arise from hair follicle. Actinic rays are a major contributing factor in the etiology. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_217_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406790PMC
May 2017
13 Reads

Sox10 and DOG1 Expression in Primary Adnexal Tumors of the Skin.

Am J Dermatopathol 2017 Dec;39(12):896-902

Departments ofPathology, and.

Primary skin adnexal tumors can be challenging to classify and must be discerned from cutaneous adenocarcinoma metastases from various sites. We evaluated expression of Sox10 and DOG1 in normal cutaneous adnexa and in 194 primary skin adnexal tumors, and compared their performance in discriminating primary skin adnexal tumors from cutaneous metastatic adenocarcinomas with that of p40 and p63. In normal skin adnexa, we noted Sox10 expression in both the secretory and myoepithelial cells in eccrine glands, but only in myoepithelial cells in apocrine glands. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000872DOI Listing
December 2017
9 Reads

The search for preoperative biomarkers for thyroid carcinoma: application of the thyroid circadian clock properties.

Biomark Med 2017 Mar 16;11(3):285-293. Epub 2017 Feb 16.

Department of Cell Physiology & Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Accumulating evidence suggests that alterations in the molecular clocks underlying the circadian time-keeping system might be connected to changes in cell cycle, resulting in oncogenic transformation. The hypothalamic-pituitary-thyroid axis is driven by a circadian clock at several levels, with an endocrine feedback loop regulating thyroid-stimulating hormone. Changes in the expression levels of circadian and cell cycle markers may correlate with clinic-pathological characteristics in differentiated follicular thyroid carcinomas. Read More

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http://dx.doi.org/10.2217/bmm-2016-0316DOI Listing
March 2017
6 Reads

Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells.

Toxicol In Vitro 2017 Apr 5;40:297-304. Epub 2017 Feb 5.

School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

As adverse health effects of bisphenol A (BPA) become a growing public health concern, the chemicals substituting BPA have been increasingly used in everyday lives. BPA substitutes have been frequently detected in both environment and biota in increasing levels. However, very limited toxicological information is available for these chemicals. Read More

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http://dx.doi.org/10.1016/j.tiv.2017.02.004DOI Listing
April 2017
58 Reads

Keratoacanthoma of the conjunctiva - case report and review of the literature.

Rom J Morphol Embryol 2017 ;58(4):1605-1609

Discipline of Histology, Department of Morphological Sciences, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Introduction: Keratoacanthoma (KA) is a relatively common, benign, rapidly growing and self-limiting squamous proliferation, which appears most frequently on the sun-exposed skin. The nature of KA and its relationship to squamous cell carcinoma (SCC) still represent one of the major debates in dermatopathology, as it is the truthfulness of such a diagnosis outside the skin. However, the tumor is now known to originate from the pilosebaceous units of the skin or from ectopic sebaceous glands of squamous mucous membranes, and to differentiate onto follicular isthmus÷infundibulum-like epithelium. Read More

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September 2018
5 Reads

Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature.

Case Rep Pathol 2016 27;2016:7169564. Epub 2016 Nov 27.

The Thyroid, Parathyroid and Pituitary Center for Miami, Internal Medicine Department, Miami Beach, FL, USA.

Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Read More

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http://dx.doi.org/10.1155/2016/7169564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149621PMC
November 2016
16 Reads

Follicular Malignant Melanoma: A Rare Morphologic Variant of Melanoma. Report of a Case and Review of the Literature.

Am J Dermatopathol 2017 May;39(5):e69-e70

*Department of Dermatology, University of Illinois at Chicago, Chicago, IL; †Advanced Dermatology and Mohs Surgery, Batavia, IL; and ‡Consolidated Pathology Consultants, Libertyville, IL.

Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000799DOI Listing
May 2017
10 Reads

The role of DOG1 immunohistochemistry in dermatopathology.

Authors:
Keisuke Goto

J Cutan Pathol 2016 Nov 5;43(11):974-983. Epub 2016 Sep 5.

Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan.

Background: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

Methods: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

Results: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. Read More

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http://dx.doi.org/10.1111/cup.12787DOI Listing
November 2016
7 Reads

Expression of PACAP and PAC1 Receptor in Normal Human Thyroid Gland and in Thyroid Papillary Carcinoma.

J Mol Neurosci 2016 Oct 26;60(2):171-8. Epub 2016 Aug 26.

Department of Anatomy, University of Pecs, 7624, Szigeti u 12, Pecs, Hungary.

Pituitary adenylate cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal peptide-secretin-glucagon peptide family, isolated first from ovine hypothalamus. The diverse physiological effects of PACAP are known mainly from animal experiments, including several actions in endocrine glands. Alteration of PACAP expression has been shown in several tumors, but changes in expression of PACAP and its specific PAC1 receptor in human thyroid gland pathologies have not yet been investigated. Read More

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http://dx.doi.org/10.1007/s12031-016-0823-7DOI Listing
October 2016
45 Reads

A case of Basaloid Follicular Hamartoma.

Fukuoka Igaku Zasshi 2016 08;107(8):155-60

We here describe a case of solitary basaloid follicular hamartoma (BFH) : the case developing in company with senile lentigo on the nose. BFH is a relatively rare benign follicular neoplasm of undetermined etiology. Histologically, the specimen consisted of small-sized squamoid or basaloid cells and follicular germ-like cells in the periphery of the tumor nests. Read More

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August 2016
9 Reads

Inverted follicular keratosis successfully treated with imiquimod.

Indian Dermatol Online J 2016 May-Jun;7(3):177-9

Department of Dermatology, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.

Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum characterized by exo-endophytic growing. It is thought to be a rare variant of the seborrheic keratosis. The diagnosis of inverted follicular keratosis is generally established histopathologically because clinical differentiation from other lesions is difficult. Read More

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http://dx.doi.org/10.4103/2229-5178.182354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886589PMC
June 2016
31 Reads

Dermoscopy of inverted follicular keratosis: study of 12 cases.

Clin Exp Dermatol 2016 Jul 28;41(5):468-73. Epub 2016 Mar 28.

Department of Dermatology, Melanoma Unit, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.

Background: Inverted follicular keratosis (IFK) is an uncommon benign tumour of the follicular infundibulum, which is often misdiagnosed clinically as other keratinizing tumours, and commonly diagnosed correctly by histopathology. There are few reports about the dermoscopic findings of this lesion.

Aim: To evaluate the dermoscopic features of IFK. Read More

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http://dx.doi.org/10.1111/ced.12832DOI Listing
July 2016
9 Reads

Benign follicular tumors.

An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8

Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20154114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689065PMC
June 2016
16 Reads

Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall.

Int J Surg Pathol 2016 May 27;24(3):232-6. Epub 2015 Dec 27.

Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

Pseudocarcinomatous hyperplasia (PCH) is a reactive proliferation of the epidermis that can be associated with many inflammatory and neoplastic conditions. Histologically, it is characterized by irregular strands of epidermis, usually at the level of the follicular infundibulum, projecting downward into the dermis. The differentiation between a well-differentiated squamous cell carcinoma and PCH can be particularly challenging when the biopsy is superficial and the causing lesion is dermal-based. Read More

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http://dx.doi.org/10.1177/1066896915623364DOI Listing
May 2016
6 Reads

Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach.

J Am Acad Dermatol 2016 Feb 6;74(2):356-62. Epub 2015 Dec 6.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

Background: Squamous cell carcinoma in situ (SCCis) has been reported to involve the hair follicle epithelium. Deep follicular invasion is often cited as a cause of treatment failure.

Objective: We sought to define the frequency and the depth of hair follicle invasion by SCCis. Read More

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http://dx.doi.org/10.1016/j.jaad.2015.09.060DOI Listing
February 2016
25 Reads

A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.

Biol Reprod 2015 Sep 22;93(3):69. Epub 2015 Jul 22.

Department of Reproductive Medicine and Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California.

Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat model using letrozole (LET), a nonsteroidal aromatase inhibitor, mimicked multiple PCOS phenotypes, including metabolic features absent in other models. Given the advantages of using genetic and transgenic mouse models, we investigated whether LET produces a similar PCOS phenotype in mice. Read More

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http://dx.doi.org/10.1095/biolreprod.115.131631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710190PMC
September 2015
37 Reads

Eruptive Tumors of the Follicular Infundibulum: An Unexpected Diagnosis of Hypopigmented Macules.

Dermatol Ther (Heidelb) 2015 Sep 5;5(3):207-11. Epub 2015 Jul 5.

Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Tumor of the follicular infundibulum (TFI) is considered as a rare benign neoplasm providing two distinctive clinical patterns: the solitary and the eruptive form. The clinical presentations resemble many other dermatologic conditions and require histopathological study to make a definite diagnosis.

Objective: To inform physicians of a clinical presentation of TFI. Read More

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http://dx.doi.org/10.1007/s13555-015-0079-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580659PMC
September 2015
5 Reads

Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus.

J Cutan Pathol 2015 Sep 12;42(9):645-51. Epub 2015 May 12.

Department of Dermatology, University of Iowa, Iowa City, IA, USA.

Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. Read More

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http://dx.doi.org/10.1111/cup.12489DOI Listing
September 2015
13 Reads

Mode of action and human relevance of pronamide-induced rat thyroid tumors.

Regul Toxicol Pharmacol 2015 Apr 20;71(3):541-51. Epub 2015 Feb 20.

Dow AgroSciences, LLC, Indianapolis, IN 46268, USA.

Pronamide, a selective, systemic, pre- and post-emergence herbicide, caused an increased incidence of thyroid follicular cell adenomas in a rat carcinogenicity study. Thyroid tumors, as well as liver and pituitary changes, were limited only to the high-dose group. The evidence for and against specific potential modes of action (MoAs) for rat thyroid follicular cell adenomas and their relevance to humans is discussed. Read More

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http://dx.doi.org/10.1016/j.yrtph.2015.02.012DOI Listing
April 2015
6 Reads

Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines.

Aquat Toxicol 2015 Mar 22;160:188-96. Epub 2015 Jan 22.

School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address:

Triphenyl phosphate (TPP), one of the most widely used organophosphate flame retardants (OPFRs), has frequently been detected in the environment and biota. However, knowledge of its toxicological effects is limited. The present study was conducted to determine the adverse effects of TPP on the thyroid endocrine system of embryonic/larval zebrafish, and the underlying mechanisms for these effects were studied using rat pituitary (GH3) and thyroid follicular (FRTL-5) cell lines. Read More

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http://dx.doi.org/10.1016/j.aquatox.2015.01.016DOI Listing
March 2015
11 Reads

Multiple tumors of the follicular infundibulum: a cutaneous reaction pattern?

Cutis 2014 Dec;94(6):301-3

88 Jiefang Rd, Hangzhou, Zhejiang Province, China 310009.

The etiology of tumor of the follicular infundibulum (TFI) is unknown. Eruptive forms of TFI are rare. We present the case of a 49-year-old woman with multiple lesions on the arms, shoulders, trunk, buttocks, and legs of more than 3 years' duration. Read More

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December 2014
3 Reads

Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors.

Regul Toxicol Pharmacol 2014 Dec 17;70(3):673-80. Epub 2014 Oct 17.

Bayer SAS, Bayer CropScience, 355 rue Dostoïevski, CS 90153, 06906 Sophia Antipolis, France.

Fluopyram, a broad spectrum fungicide, caused an increased incidence of thyroid follicular cell (TFC) adenomas in males at the highest dose evaluated (750ppm equating to 105mg/kg/day) in the mouse oncogenicity study. A series of short-term mechanistic studies were conducted in the male mouse to characterize the mode of action (MOA) for the thyroid tumor formation and to determine if No Observed Effect Levels (NOELs) exist for each key event identified. The proposed MOA consists of an initial effect on the liver by activating the constitutive androstane (Car) and pregnane X (Pxr) nuclear receptors causing increased elimination of thyroid hormones followed by an increased secretion of thyroid stimulating hormone (TSH). Read More

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http://dx.doi.org/10.1016/j.yrtph.2014.10.003DOI Listing
December 2014
5 Reads

Thyroid circadian timing: roles in physiology and thyroid malignancies.

J Biol Rhythms 2015 Apr 19;30(2):76-83. Epub 2014 Nov 19.

Department of Medical Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital of Geneva, Geneva, Switzerland

The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing system, and interactions between this timekeeping system and environmental signals. Read More

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http://dx.doi.org/10.1177/0748730414557634DOI Listing
April 2015
6 Reads

Tumor of follicular infundibulum with unique features.

An Bras Dermatol 2014 Nov-Dec;89(6):964-6

Universidade de Santo Amaro, Santo Amaro, SP, Brazil.

Tumor of the follicular infundibulum is a rare benign cutaneous adnexal neoplasm with variable clinical presentation. In most cases the diagnosis is made with the help of histopathology, due to lack of a characteristic clinical presentation. The most common form is a solitary lesion, but it can be multiple or eruptive, then called infundibulomatose. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230666PMC
April 2015
4 Reads

Bifurcation analysis of a menstrual cycle model reveals multiple mechanisms linking testosterone and classical PCOS.

J Theor Biol 2014 Nov 28;361:31-40. Epub 2014 Jul 28.

Department of Mathematics, North Carolina State University, Raleigh, NC 27695-8205, United States; Biomathematics Program, North Carolina State University, Raleigh, NC 27695, United States. Electronic address:

A system of 16 differential equations is described which models hormonal regulation of the menstrual cycle focusing on the effects of the androgen testosterone (T) on follicular development and on the synthesis of luteinizing hormone (LH) in the pituitary. Model simulations indicate two stable menstrual cycles - one cycle fitting data in the literature for normal women and the other cycle being anovulatory because of no LH surge. Bifurcations with respect to sensitive model parameters illustrate various characteristics of polycystic ovarian syndrome (PCOS), a leading cause of female infertility. Read More

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http://dx.doi.org/10.1016/j.jtbi.2014.07.020DOI Listing
November 2014
6 Reads

Is Tumor of Follicular Infundibulum a Reaction to Dermal Scarring?

Am J Dermatopathol 2015 Jul;37(7):535-8

*Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC; †Department of Pathology, King Fahad University Hospital, University of Dammam, Dammam, Saudi Arabia; and ‡Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Tumor of follicular infundibulum (TFI) is currently believed to be a benign epithelial neoplasm with follicular differentiation. It has been suggested that TFI is associated with dermal scarring, but further investigation is needed to confirm this correlation. To approach this question, a retrospective study was presented, a total of 67 cases (64 lesions) were found in a search covering cases over a 10-year period. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000130DOI Listing
July 2015
13 Reads

Viral-associated trichodysplasia secondary to antineoplastic treatment in a patient with lymphoblastic leukemia.

Am J Dermatopathol 2014 Jun;36(6):e105-7

Department of Pathology and *Dermatology, University Hospital and School of Medicine, Santiago de Compostela, Spain.

Viral-associated trichodysplasia spinulosa is an unusual condition with distinctive clinical and histopathological features. Initially described in patients immunosupressed as a result of solid organ transplantation, it has also been reported in patients treated with immunosuppressive drugs other than cyclosporine or being treated for hematological malignancies. Patients presented with disseminated follicular, hyperkeratotic papules, and variable degrees of alopecia. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000005DOI Listing
June 2014
5 Reads

Panfolliculoma and histopathologic variants: a study of 19 cases.

Am J Dermatopathol 2014 Dec;36(12):965-71

*Ackerman Academy of Dermatopathology, New York, NY; and †Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.

Panfolliculoma (PF) is an uncommon benign follicular neoplasm exhibiting differentiation toward all components of a hair follicle. Several pathologic manifestations have been described in a limited number of cases. We studied 19 cases of PF to summarize the clinical parameters and to classify this unique neoplasm histopathologically. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000108DOI Listing
December 2014
59 Reads

Tumor of follicular infundibulum: an unsuspected cause of macular hypopigmentation.

Indian J Dermatol Venereol Leprol 2014 Mar-Apr;80(2):141-4

Delhi Dermpath Laboratory, New Delhi, India.

We present three cases of a rare eruptive variant of tumor of follicular infundibulum. Two patients presented with hypopigmented macules. The clinical differential diagnoses considered in these two cases were vitiligo, lichen sclerosus et atrophicus, and idiopathic guttate hypomelanosis. Read More

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http://dx.doi.org/10.4103/0378-6323.129391DOI Listing
November 2014
6 Reads

Development of six tumors in a sebaceus nevus of jadassohn: report of a case.

Korean J Pathol 2013 Dec 24;47(6):569-74. Epub 2013 Dec 24.

Department of Family Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. ; Department of Family Medicine, University of Antwerp, Antwerp, Belgium.

Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Read More

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http://dx.doi.org/10.4132/KoreanJPathol.2013.47.6.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887160PMC
December 2013
8 Reads

Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction.

Authors:
R G Ahmed

J Endocrinol 2013 Dec 28;219(3):205-15. Epub 2013 Oct 28.

Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, PO 62514, Egypt.

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that can severely disrupt the endocrine system. In the present study, early-weaned male rats were administered a single dose of 2,3,6-2',5'-pentachlorinated biphenyl (PCB 95; 32 mg/kg per day, by i.p. Read More

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http://dx.doi.org/10.1530/JOE-13-0302DOI Listing
December 2013
7 Reads

Pituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas.

Folia Neuropathol 2013 ;51(3):261-8

Maria Maksymowicz, MD, PhD, Department of Pathology, M. Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 5 W.L. Roentgena Str., 02-781 Warsaw, Poland, phone: +48 22 546 28 08, fax: +48 22 546 29 84, e-mail:

Metastases to the pituitary gland and sella turcica are uncommon. The distinction between primary and secondary metastatic pituitary tumours is challenging as carcinomas from distant sites might closely resemble, both clinically and histopathologically, non-functional adenomas or primary pituitary carcinomas. Among metastases to pituitary gland ones from thyroid carcinoma are extremely rare. Read More

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March 2014
5 Reads

Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference.

PLoS One 2013 3;8(10):e74596. Epub 2013 Oct 3.

State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Infectious Diseases, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China ; Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education. College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.

Inhibin, a member of the transforming growth factor-β [TGF-β] superfamily, is a suppressor of follicle-stimulating hormone [FSH] release through pituitary-gonadal negative feedback loop to regulate follicular development. In this study, Inhibin α-subunit [Inha] gene was knocked down successfully in mice primary anterior pituitary cells at both transcriptional and translational levels by RNAi-Ready pSIREN-RetroQ-ZsGreen Vector mediated recombinant pshRNA vectors. The results indicated that inhibin silencing significantly promoted apoptosis by up-regulating Caspase-3, Bax and Bcl-2 genes without affecting p53 both at transcriptional and translational levels. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074596PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789712PMC
June 2014
24 Reads
4 Citations
3.234 Impact Factor

Vitamin D in thyroid tumorigenesis and development.

Prog Histochem Cytochem 2013 Aug 26;48(2):65-98. Epub 2013 Jul 26.

Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Bus 902, Herestraat 49, 3000 Leuven, Belgium.

Besides its classical role in bone and calcium homeostasis, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has many non-classical effects; antiproliferative, anti-apoptotic and prodifferentiating effects of 1,25(OH)2D3 have been described in several tumour types in preclinical models. This review focuses on the insights gained in the elucidation of the role of 1,25(OH)2D3 in the normal thyroid and in the pathogenesis, progression and treatment of thyroid cancer, the most common endocrine malignancy. An increasing amount of observations points towards a role for impaired 1,25(OH)2D3-VDR signalling in the occurrence and progression of thyroid cancer, and a potential for structural analogues in the multimodal treatment of dedifferentiated iodine-resistant thyroid cancer. Read More

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http://dx.doi.org/10.1016/j.proghi.2013.07.001DOI Listing
August 2013
7 Reads

The transcription factor GATA4 is required for follicular development and normal ovarian function.

Dev Biol 2013 Sep 14;381(1):144-58. Epub 2013 Jun 14.

Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.

Sex determination in mammals requires interaction between the transcription factor GATA4 and its cofactor FOG2. We have recently described the function of both proteins in testis development beyond the sex determination stage; their roles in the postnatal ovary, however, remain to be defined. Here, we use gene targeting in mice to determine the requirement of GATA4 and FOG2 in ovarian development and folliculogenesis. Read More

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http://dx.doi.org/10.1016/j.ydbio.2013.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089064PMC
September 2013
12 Reads

Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway.

Biochem Biophys Res Commun 2013 Jul 6;436(3):443-8. Epub 2013 Jun 6.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Activin, a transforming growth factor β family member, has a wide range of physiological roles during embryonic development and organogenesis. In the ovary, activin, secreted from ovarian granulosa cells, not only acts on the pituitary gland to regulate the gonadotropin secretion from the pituitary gland in an endocrine manner but also acts on granulosa cells in a paracrine/autocrine manner to regulate folliculogenesis. Previously, we showed that activin signals through activin type IB receptor (ActRIB) and up-regulates follicle-stimulating hormone receptor expression and P450 aromatase activity in human ovarian granulose cell-like KGN cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2013.05.124DOI Listing
July 2013
8 Reads

Solitary and multiple tumors of follicular infundibulum: a review of 168 cases with emphasis on staining patterns and clinical variants.

J Cutan Pathol 2013 Jun 27;40(6):532-7. Epub 2013 Mar 27.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Background: Tumor of the follicular infundibulum (TFI) is an uncommon benign adnexal tumor that usually presents as a solitary keratotic papule in the head and neck area. Infrequently, it may present as multiple lesions or in association with other conditions. Although it was initially described in 1961, the pathogenesis of this lesion is still controversial. Read More

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http://doi.wiley.com/10.1111/cup.12137
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http://dx.doi.org/10.1111/cup.12137DOI Listing
June 2013
10 Reads