2,899 results match your criteria Follicle-Stimulating Hormone Abnormalities


A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):49-54. Epub 2019 Mar 31.

Department of Pediatric Endocrinology and Diabetology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Mutations in the CHD7 gene, encoding for the chromodomain helicase DNA-binding protein 7, are found in approximately 60% of individuals with CHARGE syndrome (coloboma, heart defects, choanal atresia, retarded growth and development, genital hypoplasia, ear abnormalities and/or hearing loss). Herein, we present a clinical case of a 14-year-old male presenting for evaluation of poor growth and pubertal delay highlighting the diagnostic challenges of CHARGE syndrome. The patient was born full term and underwent surgery at 5 days of life for bilateral choanal atresia. Read More

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http://dx.doi.org/10.6065/apem.2019.24.1.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449621PMC
March 2019
2 Reads

Cannabis and Male Fertility: A Systematic Review.

J Urol 2019 Mar 27:101097JU0000000000000248. Epub 2019 Mar 27.

Division of Urology, Department of Surgery, University of Utah School of Medicine , Salt Lake City , UT.

Introduction: With cannabis consumption on the rise, and use prominent among males of reproductive age, it is essential to understand the potential impact of cannabis on male fertility. Here we review the literature regarding cannabis' effects on male fertility.

Materials And Methods: A literature search was conducted using PubMed/MEDLINE to identify relevant studies examining the effects of cannabis on male fertility. Read More

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http://dx.doi.org/10.1097/JU.0000000000000248DOI Listing
March 2019
14 Reads

Combined study on the single nucleotide polymorphisms in the follicle-stimulating hormone receptor (Ser680Asn) and anti-Müllerian hormone receptor type II (-482A>G) as genetic markers in assisted reproduction.

Horm Mol Biol Clin Investig 2019 Mar 25. Epub 2019 Mar 25.

1st Department of Obstetrics and Gynecology, Alexandra Hospital, Division of Human Reproduction, IVF Unit National and Kapodistrian University of Athens, Medical School, 62 Sirinon Street, P. Faliro, 175 61 Athens, Greece, Phone: +30 6932421747, Fax: +30 210 6454902.

Background Infertile women may have underlying genetic abnormalities. There is, at present, a significant number of studies on the relation between the follicle stimulating hormone receptor (FSHR) or anti-Müllerian hormone type II receptor (AMHRII) polymorphisms and response to in-vitro fertilisation (IVF) treatment. However, it is not yet clear which genotype or combination of genotypes is favourable towards a better ovarian stimulation and pregnancy outcome. Read More

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http://dx.doi.org/10.1515/hmbci-2018-0077DOI Listing
March 2019
1 Read

Clinical, biochemical, and molecular overview of transaldolase deficiency and evaluation of the endocrine function: Update of 34 patients.

J Inherit Metab Dis 2019 Jan;42(1):147-158

Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

Background: Transaldolase deficiency (TALDO-D) is a rare autosomal recessive inborn error of the pentose phosphate pathway. Since its first description in 2001, several case reports have been published, but there has been no comprehensive overview of phenotype, genotype, and phenotype-genotype correlation.

Methods: We performed a retrospective questionnaire and literature study of clinical, biochemical, and molecular data of 34 patients from 25 families with proven TALDO-D. Read More

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http://dx.doi.org/10.1002/jimd.12036DOI Listing
January 2019
4 Reads

Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial.

Lancet 2019 02;393(10170):416-422

Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.

Background: Sperm selection strategies aimed at improving success rates of intracytoplasmic sperm injection (ICSI) include binding to hyaluronic acid (herein termed hyaluronan). Hyaluronan-selected sperm have reduced levels of DNA damage and aneuploidy. Use of hyaluronan-based sperm selection for ICSI (so-called physiological ICSI [PICSI]) is reported to reduce the proportion of pregnancies that end in miscarriage. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32989-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409400PMC
February 2019
9 Reads

Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.

Environ Sci Pollut Res Int 2019 Mar 29;26(8):8202-8211. Epub 2019 Jan 29.

Department of Biological Sciences, Faculty of Science, College of Science, King Faisal University, Hofuf, Al-Ahsa, 31982, Saudi Arabia.

The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5 mg/kg) alone or in combination with QUE (50 mg/kg) daily for 4 weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Read More

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http://link.springer.com/10.1007/s11356-019-04276-1
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http://dx.doi.org/10.1007/s11356-019-04276-1DOI Listing
March 2019
13 Reads
2.828 Impact Factor

Slipped capital femoral epiphysis in an adult with congenital hypopituitarism: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e13997

Department of Orthopedic Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: Slipped capital femoral epiphysis (SCFE) is a common hip problem in adolescents, usually individuals between 8 and 15 years old. Because of the frequent finding of growth abnormalities in affected children, various endocrine disturbances have been reported as the cause of the disease. However, there are few case reports of older patients in previous literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000013997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370171PMC
January 2019
11 Reads

Occupational and Environmental Exposure to Lead and Reproductive Health Impairment: An Overview.

Authors:
Sunil Kumar

Indian J Occup Environ Med 2018 Sep-Dec;22(3):128-137

Former Director, National Institute of Occupational Health, Ahmedabad, India.

Lead is a heavy metal. It is used in lead-acid battery, as a coloring agent, paints, and metal alloyed as shielding materials, smelters, printing press, and so on. It is a toxic metal affecting various organs, and developing fetus and young children are more vulnerable to toxicity of lead. Read More

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http://dx.doi.org/10.4103/ijoem.IJOEM_126_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309352PMC
January 2019
21 Reads

Acute diethyl nitrosamine and cadmium co-exposure exacerbates deficits in endocrine balance, sperm characteristics and antioxidant defence mechanisms in testes of pubertal rats.

Andrologia 2019 May 27;51(4):e13230. Epub 2018 Dec 27.

Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Diethylnitrosamine (DEN) and cadmium are environmental contaminants of known poisonous consequences in animals and humans. We examined the influence of acute oral co-exposure to DEN (10 mg/kg) and cadmium (5 mg/kg) on endocrine balance, semen and antioxidant status in rat testes. The results indicated decreases (p < 0. Read More

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http://dx.doi.org/10.1111/and.13230DOI Listing
May 2019
3 Reads

Sport, doping and female fertility.

Reprod Biol Endocrinol 2018 Nov 19;16(1):108. Epub 2018 Nov 19.

Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", via S. Sofia 78, 95123, Catania, Italy.

This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes concerning the serum concentrations of follicle-stimulating hormone, luteinizing hormone, prolactin, growth hormone, thyroid hormones, leptin, ghrelin, neuropeptide Y. The second paragraph analyzes the effects of doping on the hypothalamic-pituitary-ovarian axis. Read More

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http://dx.doi.org/10.1186/s12958-018-0437-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241032PMC
November 2018
2 Reads
2.410 Impact Factor

Premature ovarian insufficiency - aetiopathology, epidemiology, and diagnostic evaluation.

Prz Menopauzalny 2018 Sep 30;17(3):105-108. Epub 2018 Sep 30.

Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Premature ovarian insufficiency (POI) is defined as a cessation of ovarian function before the age of 40 years. It is associated with hypoestrogenism and loss of residual follicles, both of which lead to menstrual abnormalities, pregnancy failures, and decreased health-related quality of life. The prevalence of POI is estimated at 1% in the general population. Read More

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https://www.termedia.pl/doi/10.5114/pm.2018.78550
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http://dx.doi.org/10.5114/pm.2018.78550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196779PMC
September 2018
19 Reads

Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon-induced reproductive toxicity in male rats.

Environ Toxicol 2019 Feb 13;34(2):150-159. Epub 2018 Oct 13.

Chemistry Department, Faculty of Science, Menoufia University, Egypt.

This study was designed to evaluate protective effect of Saussurea lappa root aqueous extract against Ethephon (2-chloroethylphosphonic acid)-induced reproductive toxicity in rats. Control group received distilled water. Second group was given S. Read More

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http://doi.wiley.com/10.1002/tox.22669
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http://dx.doi.org/10.1002/tox.22669DOI Listing
February 2019
9 Reads

Dysbalanced sex hormone status is an independent predictor of decompensation and mortality in patients with liver cirrhosis.

Hepatol Res 2019 Feb 31;49(2):201-211. Epub 2018 Oct 31.

Vienna Hepatic Hemodynamic Laboratory, Divison of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Aims: Endocrinological abnormalities, including low testosterone levels, are prevalent in cirrhosis. We assessed sexual hormone status in regard to hemodynamic abnormalities and its impact on hepatic decompensation and survival.

Methods: Males with cirrhosis were prospectively included in this study since 2010. Read More

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http://dx.doi.org/10.1111/hepr.13253DOI Listing
February 2019
4 Reads

ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.

Genet Med 2019 04 19;21(4):930-938. Epub 2018 Sep 19.

Inserm U1185, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France.

Purpose: Primary ovarian insufficiency (POI) is a frequent disorder that affects ~1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels of follicle-stimulating hormone (FSH), leads to infertility. Although various etiological factors have been described, including chromosomal abnormalities and gene variants, most cases remain idiopathic. Read More

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http://dx.doi.org/10.1038/s41436-018-0287-yDOI Listing
April 2019
3 Reads

Differences in reproductive toxicity of TBBPA and TCBPA exposure in male Rana nigromaculata.

Environ Pollut 2018 Dec 30;243(Pt A):394-403. Epub 2018 Aug 30.

College of Life and Environmental Sciences, Hangzhou Normal University, Xuelin Road 16#, Xiasha Gaojiao Dongqu, Hangzhou, Zhejiang Province, 310036, China. Electronic address:

Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are persistent toxic environmental pollutants that cause severe reproductive toxicity in animals. The goal of this study was to compare the reproductive toxic effects of TBBPA and TCBPA on male Rana nigromaculata and to expound on the mechanisms leading to these effects. Healthy adult frogs were exposed to 0, 0. Read More

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http://dx.doi.org/10.1016/j.envpol.2018.08.086DOI Listing
December 2018
19 Reads

Type 1 Diabetes Mellitus and Klinefelter Syndrome.

Intern Med 2019 Jan 24;58(2):259-262. Epub 2018 Aug 24.

Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Japan.

A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (>100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laboratory examination found high luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels and low testosterone levels, and a chromosome analysis (47, XXY) indicated hypogonadism due to Klinefelter syndrome (KS). Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1051-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378147PMC
January 2019
12 Reads

Sex hormone Profile in Human Immunodeficiency Virus-Infected Men and It's Correlation with CD4 Cell Counts.

Indian J Endocrinol Metab 2018 May-Jun;22(3):328-334

Department of Medicine, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: In human immunodeficiency virus (HIV)-infected men, hypogonadism is the most common endocrinological disorder, and most cases of hypogonadism are secondary. The aim of this study was to find out the hormonal abnormalities in HIV-infected males and it's correlation with CD4 cell counts.

Materials And Methods: One hundred HIV-infected male patients were evaluated in the Department of Medicine, Postgraduate Institute of Medical Education and Research and Dr. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_694_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063178PMC
August 2018
24 Reads

Florid hyperandrogenism due to a benign adrenocortical adenoma.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Endocrinologist, Centre of Endocrinology Diabetes & Metabolism, Limassol, Cyprus.

A 26-year-old woman with a history of polycystic ovarian syndrome presented with secondary amenorrhea, worsening hirsutism, acne, deepening of voice and unexplained 10-20 kg weight gain. Her Ferriman-Gallway hirsutism score was 12 with cystic facial acne and increased masculine phenotype. Urine Beta-Human Chorionic Gonadotropins (bHCG) was negative. Read More

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http://dx.doi.org/10.1136/bcr-2018-224804DOI Listing
July 2018
19 Reads

Embryonic estrogen exposure recapitulates persistent ovarian transcriptional programs in a model of environmental endocrine disruption.

Biol Reprod 2019 Jan;100(1):149-161

Savannah River Ecology Laboratory, Aiken, South Carolina, USA.

Estrogens regulate key aspects of sexual determination and differentiation, and exposure to exogenous estrogens can alter ovarian development. Alligators inhabiting Lake Apopka, FL, are historically exposed to estrogenic endocrine disrupting contaminants and are characterized by a suite of reproductive abnormalities, including altered ovarian gene expression and abated transcriptional responses to follicle stimulating hormone. Here, we test the hypothesis that disrupting estrogen signaling during gonadal differentiation results in persistent alterations to ovarian gene expression that mirror alterations observed in alligators from Lake Apopka. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy165DOI Listing
January 2019
11 Reads

Outcomes following transsphenoidal surgical management of incidental pituitary adenomas: a series of 52 patients over a 17-year period.

J Neurosurg 2018 Jun 1:1-9. Epub 2018 Jun 1.

1Department of Neurosurgery, Division of Endocrinology.

OBJECTIVEIncidental pituitary adenomas (IPAs) are commonly discovered during cranial imaging evaluations obtained for unrelated indications. The optimal management of IPA remains controversial. The authors investigated the outcomes and safety of the surgical treatment of IPAs at their institution. Read More

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http://dx.doi.org/10.3171/2017.11.JNS171485DOI Listing
June 2018
10 Reads

Delayed puberty versus hypogonadism: a challenge for the pediatrician.

Ann Pediatr Endocrinol Metab 2018 Jun 20;23(2):57-61. Epub 2018 Jun 20.

Department of Pediatrics, Pediatric and Infectious Diseases Unit, Bambino Gesù Children Hospital IRCCS, Rome, Italy.

Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal maturation. A family history of the subject comprising the timing of puberty in the parents and physical examination may provide clues regarding the cause of DP. Delayed onset of puberty is rarely considered a disease in either sex. Read More

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http://e-apem.org/journal/view.php?doi=10.6065/apem.2018.23.
Publisher Site
http://dx.doi.org/10.6065/apem.2018.23.2.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057016PMC
June 2018
29 Reads

Serum sex hormones concentrations in young women in the early period after successful kidney transplantation.

Endokrynol Pol 2018 ;69(2):150-155

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland.

Background: Hormonal disorders are frequently present in hemodialysed patients with chronic kidney disease (CKD). In women with CKD sex hormones abnormalities may lead to irregular, often anovulatory cycles, sexual dysfunction and infertility. Kidney transplantation done in young women tends to ameliorate most of the aforementioned disorders and improve fertility. Read More

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http://dx.doi.org/10.5603/EP.2018.0019DOI Listing
October 2018
5 Reads

Sex Differences in Reproductive Hormones During Mini-Puberty in Infants With Normal and Disordered Sex Development.

J Clin Endocrinol Metab 2018 08;103(8):3028-3037

Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.

Context: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exist on sex-specific reference ranges for these hormones during early life.

Objective: To evaluate sex differences in reproductive hormone concentrations in serum from healthy infants to define sex-specific cutoff values and to apply these in infants with DSD. Read More

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https://academic.oup.com/jcem/article/103/8/3028/5037960
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http://dx.doi.org/10.1210/jc.2018-00482DOI Listing
August 2018
10 Reads

Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility.

Syst Biol Reprod Med 2019 Feb 9;65(1):20-28. Epub 2018 Jun 9.

a Academician A.I. Strukov Department of Pathology , Sechenov University , Moscow , Russia.

Inhibin B is one of the most significant serum markers of spermatogenesis, but its testicular expression has been poorly studied. Inhibin B sensitivity as well as the ability to reflect the level and condition of spermatogenesis and forecast certain changes in reproductive homeostasis in males is still a subject of active discussion. The purpose of this study is to examine the level of expression of inhibin B in cells of human seminiferous tubules in normal and in pathological spermatogenesis (idiopathic infertility) by revealing the proportion of immunostaining cells for inhibin B. Read More

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http://dx.doi.org/10.1080/19396368.2018.1478470DOI Listing
February 2019
15 Reads

Hormonal Predictors of Abnormal Luteal Phases in Normally Cycling Women.

Front Public Health 2018 24;6:144. Epub 2018 May 24.

Hospices Civils de Lyon, Service de Biostatistique-Bioinformatique, Lyon, France.

Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Observational study. Eight European natural family planning clinics. Read More

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http://dx.doi.org/10.3389/fpubh.2018.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978451PMC
May 2018
23 Reads

Impaired serotonin communication during juvenile development in rats diminishes adult sperm quality.

Syst Biol Reprod Med 2018 Oct 22;64(5):340-347. Epub 2018 May 22.

b Facultad de Estudios Superiores Iztacala , UNAM , Tlalnepantla , Estado de México.

Spermatogenesis and steroidogenesis are testicular functions regulated by gonadotrophins as well as other factors, including serotonin. Testicular serotonin acts as an autocrine regulator of testosterone secretion, but studies on its role in spermatogenesis and sperm quality are scarce. Here, we analyzed the effects of intratesticular inhibition of serotonin synthesis on gonadotrophins, testosterone, and sperm quality. Read More

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http://dx.doi.org/10.1080/19396368.2018.1472825DOI Listing
October 2018
2 Reads

Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters.

Reprod Biomed Online 2018 08 7;37(2):163-171. Epub 2018 May 7.

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium; Department of Obstetrics and Gynaecology, School of Medicine, University of Zagreb, Croatia.

Research Question: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment?

Design: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed.

Results: After conventional ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol, the median number of oocytes retrieved ranged between 11 and 13. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.05.003DOI Listing
August 2018
5 Reads

Study of anti-Müllerian hormone levels in patients with Myotonic Dystrophy Type 1. Preliminary results.

Acta Myol 2017 Dec 1;36(4):199-202. Epub 2017 Dec 1.

Cardiomyology and Medical Genetics and University of Campania "Luigi Vanvitelli", Naples, Italy.

Myotonic dystrophy type 1 is a multisystemic disorder characterized by myotonia, muscle weakness and involvement of several organs and apparatus such as heart, lungs, eye, brain and endocrine system. Hypogonadism and reproductive abnormalities are frequently reported. A progressive testicular atrophy occurs in about 80% in the affected males leading to Leydig cell hyperproliferation and elevated basal follicle stimulating hormone (FSH) levels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953232PMC
December 2017
12 Reads

Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice.

Int J Nanomedicine 2018 27;13:2543-2549. Epub 2018 Apr 27.

Library of Soochow University, Suzhou, People's Republic of China.

Background: Exposure to titanium dioxide nanoparticles (TiO NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO NPs application on premature ovarian failure (POF) have rarely been evaluated to date.

Methods: In this study, female mice were continuously exposed to TiO NPs at doses of 2. Read More

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http://dx.doi.org/10.2147/IJN.S151215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927354PMC
June 2018
14 Reads

The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.

Reprod Biol Endocrinol 2018 May 4;16(1):44. Epub 2018 May 4.

Key Lab of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Xietu Road 2140, Xuhui District, Shanghai, 200032, China.

Background: LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities. Although the actions of leptin and lepR in the control of reproductive function are thought to be exerted mainly via the hypothalamic-pituitary-gonadal axis, relatively less is known regarding their local effects on the peripheral ovary, especially on steroid hormone synthesis. Meanwhile, whether the decreased fertility of Y123F mouse could be restored by gonadotropin has not been clear yet. Read More

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https://rbej.biomedcentral.com/articles/10.1186/s12958-018-0
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http://dx.doi.org/10.1186/s12958-018-0365-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934784PMC
May 2018
11 Reads

[Micro-dissection testicular sperm extraction for patients with non-obstructive azoospermia: A report of 196 cases].

Zhonghua Nan Ke Xue 2017 Sep;23(9):804-807

Center of Reproductive Medicine, The Sixth Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong 510620, China.

Objective: To investigate the effect of micro-dissection testicular sperm extraction (microTESE) for patients with non-obstructive azoospermia (NOA) and the indications of the strategy.

Methods: This retrospective study included 196 cases of NOA undergoing microTESE in our center from September 2014 to March 2017. We recorded the sperm retrieval rate (SRR) and analyzed its correlation with the patients' age, testis volume, level of blood follicle-stimulating hormone (FSH), and etiological factors. Read More

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September 2017
9 Reads

Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease.

Exp Ther Med 2018 May 6;15(5):4259-4264. Epub 2018 Mar 6.

Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.

The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group. Read More

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http://dx.doi.org/10.3892/etm.2018.5932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920378PMC
May 2018
9 Reads

Elevated androstenedione in young adult but not early adolescent prenatally androgenized female rats.

PLoS One 2018 3;13(5):e0196862. Epub 2018 May 3.

Department of Biochemistry, Lake Erie College of Osteopathic Medicine, Erie, PA, United States of America.

Background: Elevated testosterone (T) is routinely reported as a marker of hyperandrogenemia in rodent models for polycystic ovary syndrome (PCOS). In women with PCOS, elevated serum androstenedione (A4) is associated with more severe phenotypes, including a positive correlation with serum T, DHEAS, free androgen index (FAI), LH, and LH/FSH ratio. Furthermore, A4, along with calculated free T and FAI, was identified as one of the best predictors of PCOS in adult women of all ages (18 to > 50 y). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196862PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933698PMC
August 2018
3 Reads

Complex chromosomal aberrations in a fetus originating from oocytes with smooth endoplasmic reticulum (SER) aggregates.

Syst Biol Reprod Med 2018 Aug 2;64(4):283-290. Epub 2018 May 2.

c Unit for Human Reproduction, 1st Department of Obstetrics & Gynecology, Papageorgiou General Hospital, Medical School , Aristotle University of Thessaloniki , Thessaloniki , Greece.

The presence of smooth endoplasmic reticulum aggregates (SERa) in the ooplasm is considered as the most severe oocyte dysmorphism due to its serious and potentially lethal outcomes in offspring. In the present case report, a couple underwent their first intracytoplasmic sperm injection (ICSI) cycle using a gonadotrophin releasing hormone (GnRH) antagonist protocol, followed by fetal ultrasound scanning and amniocentesis. SERa were observed in all oocytes retrieved. Read More

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https://www.tandfonline.com/doi/full/10.1080/19396368.2018.1
Publisher Site
http://dx.doi.org/10.1080/19396368.2018.1466375DOI Listing
August 2018
12 Reads

Chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar and their association with sperm retrieval intracytoplasmic sperm injection outcomes.

Arab J Urol 2018 03 23;16(1):132-139. Epub 2017 Dec 23.

Urology Department, Hamad Medical Corporation, Doha, Qatar.

Objective: To study the types and incidence of chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar, and to compare the hormonal changes, testicular sperm retrieval rate, and intracytoplasmic sperm injection (ICSI) outcome between patients with chromosomal abnormalities and patients with idiopathic infertility.

Patients And Methods: This study involved the retrospective chart review of 625 infertile male patients attending an academic tertiary medical centre in Qatar. Retrieved information included data on medical history, family history, clinical examination, semen analysis, initial hormonal profiles, and genetic studies, ICSI, and sperm retrieval results. Read More

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http://dx.doi.org/10.1016/j.aju.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922002PMC
March 2018
7 Reads

[Treatment of Rathke's Cleft Cyst:Technical Note for Preservation of Pituitary Function].

No Shinkei Geka 2018 Apr;46(4):313-317

Department of Neurosurgery, Faculty of Medicine, Yamagata University.

Pituitary dysfunction, such as panhypopituitarism or diabetes insipidus(DI), is often found in patients with Rathke's cleft cyst. Patients were treated with transsphenoidal microscopic surgery; however, pituitary dysfunction did not usually recover. Recently, endoscopic transsphenoidal surgery(eTSS)has enabled minimally invasive surgery for patients with Rathke's cleft cyst. Read More

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http://dx.doi.org/10.11477/mf.1436203722DOI Listing
April 2018
2 Reads

Ovarian reserve in young juvenile idiopathic arthritis patients.

Mod Rheumatol 2018 May 4:1-5. Epub 2018 May 4.

a Pediatric Rheumatology Unit , Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo , Sao Paulo , Brazil.

Objectives: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are no systematic data regarding ovarian function in this disease.

Methods: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL). Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2018.1
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http://dx.doi.org/10.1080/14397595.2018.1465646DOI Listing
May 2018
5 Reads

45,X/46,XY Mosaicism Presenting With Isolated Unilateral Cryptorchidism and a Normal Blood Karyotype.

J Clin Endocrinol Metab 2018 06;103(6):2079-2082

Department of Endocrinology, Great Ormond Street Hospital for Children, London, United Kingdom.

Context: 45,X/46,XY mosaicism is a disorder of sex development leading to abnormal gonadal development and to unpredictable genital phenotype, growth, and pubertal development.

Case Description: A 2-year-old male presented with a right impalpable testis. Blood karyotype was 46,XY. Read More

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http://dx.doi.org/10.1210/jc.2017-02671DOI Listing
June 2018
3 Reads

Aromatase Deficiency due to a Novel Mutation in Gene

J Clin Res Pediatr Endocrinol 2018 11 19;10(4):377-381. Epub 2018 Mar 19.

Dicle University Faculty of Medicine, Department of Pediatric Endocrinology, Diyarbakır, Turkey

Aromatase deficiency is a rare autosomal recessive genetic disorder with an unknown incidence. Aromatase converts androgens into estrogen in the gonadal and extra-gonadal tissues. Aromatase deficiency causes ambiguous genitalia in the female fetus and maternal virilization (hirsutism, acne, cliteromegaly, deep voice) during pregnancy due to increased concentration of androgens. Read More

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http://dx.doi.org/10.4274/jcrpe.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280327PMC
November 2018
10 Reads

Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China.

Reprod Biol Endocrinol 2018 Mar 14;16(1):23. Epub 2018 Mar 14.

The Reproductive Medical Centre, Nanjing Jinling Hospital, Nanjing University School of Medicine, 305 Zhongshan East Road, Nanjing, 210002, Jiangsu, China.

Background: Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and seminal plasma.

Methods: In our prospective study, a total of 1 010 subfertile men, aged from 18 to 50 years old, were enrolled from August 2012 through June 2015. Read More

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http://dx.doi.org/10.1186/s12958-018-0345-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852972PMC
March 2018
5 Reads

Clinical aspects of 49 infertile males with 45,X/46,XY mosaicism karyotype: A case series.

Andrologia 2018 Jun 12;50(5):e13009. Epub 2018 Mar 12.

Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Disorders of sex development (DSD) are congenital abnormalities as an atypical development process in either gonadal or chromosomal structure. It is the cause of the abnormality in phenotype and characteristics. Chromosomal analysis plays an important role in the DSD determination. Read More

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http://dx.doi.org/10.1111/and.13009DOI Listing
June 2018
7 Reads

Protective potential of royal jelly against cadmium-induced infertility in male rats.

Andrologia 2018 Jun 12;50(5):e12996. Epub 2018 Mar 12.

Department of Biochemistry, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.

This study aimed to investigate the protective potential of Royal jelly (RJ) against cadmium (Cd)-induced testicular dysfunction in rats. Thirty-five adult male Wistar rats were assigned into five groups. G I; (control) injected intraperitoneally with saline, G II injected intraperitoneally with a single dose of CdCl (1 mg/kg BW), G III received RJ (100 mg/kg BW/day) orally, G IV was pre-treated with RJ for 1 week then, treated with CdCl , and G V was co-treated with RJ and CdCl . Read More

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http://dx.doi.org/10.1111/and.12996DOI Listing
June 2018
7 Reads
1.172 Impact Factor

Vascular Malformation Enlargement During Menopause.

J Craniofac Surg 2018 Jul;29(5):1271-1272

Department of Plastic and Oral Surgery, Vascular Anomalies Center Boston Children's Hospital Harvard Medical School, Boston, MA.

Vascular malformations enlarge overtime, particularly during adolescence when follicle-stimulating hormone (FSH) rises. Lesions contain the receptor for follicle-stimulating hormone. FSH also becomes elevated during menopause. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004462DOI Listing
July 2018
6 Reads

Klinefelter syndrome and fertility-Impact of X-chromosomal inheritance on spermatogenesis.

Andrologia 2018 Jun 7;50(5):e13004. Epub 2018 Mar 7.

Department of Obstetrics and Gynaecology, Radboudumc Nijmegen, Nijmegen, The Netherlands.

With the use of testicular sperm extraction (TESE), spermatozoa can be retrieved in about 30%-50% of men with Klinefelter syndrome (KS). The reason for the absence or presence of spermatozoa in half of the men with KS remains unknown. Therefore, the search for an objective marker for a positive prediction in finding spermatozoa is of significant clinical value to avoid unnecessary testicular biopsies in males with (mostly) low testicular volume and impaired testosterone. Read More

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http://dx.doi.org/10.1111/and.13004DOI Listing
June 2018
4 Reads

Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome.

Endocr Metab Immune Disord Drug Targets 2018 ;18(4):401-406

Department of Endocrinology and Metabolism, Gulhane Training and Research Hospital - 06010, Etlik, Ankara, Turkey.

Background And Objective: Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS.

Methods: A total of 32 patients with KS (mean age 21. Read More

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http://dx.doi.org/10.2174/1871530318666180220114322DOI Listing
October 2018
9 Reads

Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence.

J Clin Endocrinol Metab 2018 04;103(4):1273-1276

Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Context: Hypothalamic kisspeptin signaling plays a critical role in the initiation and maintenance of reproductive function. Biallelic mutations in the coding sequence of KISS1R (GPR54) have been identified in patients with idiopathic hypogonadotropic hypogonadism, but it is unknown whether biallelic variants can also be associated with related reproductive disorders.

Case Description: A missense homozygous variant (c. Read More

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http://dx.doi.org/10.1210/jc.2017-02636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276658PMC
April 2018
6 Reads

Bilateral testicular torsion in a 36-week neonate.

BMJ Case Rep 2018 Feb 7;2018. Epub 2018 Feb 7.

Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

A male neonate born after uncomplicated vaginal delivery at 36 weeks' gestation was noted to have large and firm testicles bilaterally on routine examination. A testicular ultrasound scan was subsequently organised that showed detailed appearances consistent with bilateral testicular torsion. This was thought to have taken place antenatally and as such was unfortunately not suitable for intervention. Read More

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http://dx.doi.org/10.1136/bcr-2017-223093DOI Listing
February 2018
6 Reads

FSH may be a useful tool to allow early diagnosis of Turner syndrome.

BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.

Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.

Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

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http://dx.doi.org/10.1186/s12902-018-0236-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803864PMC
February 2018
14 Reads

Artificial Neural Network for the Prediction of Chromosomal Abnormalities in Azoospermic Males.

Urol J 2018 05 3;15(3):122-125. Epub 2018 May 3.

Department of Urology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Purpose: To evaluate whether an artifical neural network helps to diagnose any chromosomal abnormalities in azoospermic males.

Materials And Methods: The data of azoospermic males attending to a tertiary academic referral center were evaluated retrospectively. Height, total testicular volume, follicle stimulating hormone, luteinising hormone, total testosterone and ejaculate volume of the patients were used for the analyses. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4029DOI Listing
May 2018
6 Reads

Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes.

Int J Fertil Steril 2018 Apr 7;12(1):72-80. Epub 2018 Jan 7.

Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India. Electronic address:

Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats.

Materials And Methods: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals. Read More

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http://dx.doi.org/10.22074/ijfs.2018.5160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767937PMC
April 2018
10 Reads