3,140 results match your criteria Follicle-Stimulating Hormone Abnormalities

Divergent Associations Between Serum Androgens and Ovarian Reserve Markers Revealed in Patients With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2022 9;13:881740. Epub 2022 Jun 9.

Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

Background: The role of excess androgen in ovarian reserve remains unclear in patients with polycystic ovary syndrome (PCOS). Our study highlights the associations of serum androgen levels and ovarian reserve markers in PCOS and non-PCOS women.

Methods: Totally 584 menstrual abnormalities women of 20-45 years were retrospectively evaluated at the Beijing Obstetrics and Gynecology Hospital between January 2021 to October 2021. Read More

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Identification, characterization and functional analysis of gonadal long noncoding RNAs in a protogynous hermaphroditic teleost fish, the ricefield eel (Monopterus albus).

BMC Genomics 2022 Jun 20;23(1):450. Epub 2022 Jun 20.

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Background: An increasing number of long noncoding RNAs (lncRNAs) have been found to play important roles in sex differentiation and gonad development by regulating gene expression at the epigenetic, transcriptional and posttranscriptional levels. The ricefield eel, Monopterus albus, is a protogynous hermaphroditic fish that undergoes a sequential sex change from female to male. However, the roles of lncRNA in the sex change is unclear. Read More

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CYP19A1 Promoters Activity in Human Granulosa Cells: A Comparison between PCOS and Normal Subjects.

Cell J 2022 Apr 27;24(4):170-175. Epub 2022 Apr 27.

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Objective: Estrogen, a female hormone maintaining several critical functions in women's physiology, e.g., folliculogenesis and fertility, is predominantly produced by ovarian granulosa cells where aromatase enzyme converts androgen to estrogen. Read More

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COVID-19 and Endocrine System: A Cross-Sectional Study on 60 Patients with Endocrine Abnormality.

Cell J 2022 Apr 27;24(4):182-187. Epub 2022 Apr 27.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Email:

Objective: COVID-19 is an infectious disease that has become pandemic with a high mortality rate. This study aims to provide new insight into the relations between SARS-CoV-2 and the Endocrine system.

Materials And Methods: In this cross-sectional study, we have hospitalized 60 patients with a positive SARA-CoV-2 PCR test. Read More

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Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam.

Ann Pediatr Endocrinol Metab 2022 May 16. Epub 2022 May 16.

School of Nutrition and Health Sciences, Taipei Medical University, Taipei City, Taiwan.

Purpose: Cranial magnetic resonance imaging (MRI) is recommended to identify the existence of intracranial lesions in girls with central precocious puberty (CPP). Yet, the routine MRI scan in girls with CPP is still debatable, as the pathological finding in girls with CPP older than six years is limited. Therefore, we aimed to identify the prevalence of brain lessons stratified by age group (0-2, 2-6, and 6-8 years). Read More

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In vitro fertilization and preimplantation genetic diagnosis outcomes in mosaic Turner's syndrome: A retrospective cohort study from a single referral center experience.

J Gynecol Obstet Hum Reprod 2022 May 13;51(7):102405. Epub 2022 May 13.

Department of IVF Research and Training Center and Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.

Background: Patients with mosaic Turner syndrome who have normal phenotype and pubertal development may be diagnosed based on karyotype examination which is performed due to recurrent abortion or recurrent implantation failure; but according to the literature review, reproductive and obstetric consequences of these cases are based on case reports. There are contradictory publications on this subject recommending pre-implantation genetic testing (PGT) may be a solution to reduce the high risk for the fetus and perform normal embryo transfer.

Aim: In this study, our aim was to evaluate the results of in vitro fertilization and preimplantation genetic diagnosis in patients with low-grade and high-grade mosaic Turner syndrome. Read More

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Impact of the Living Donor Age and the Hormonal Profile of Algerian Renal Transplant Recipients

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1374-1381

Department of Biochemistry, Central Laboratory of Biology, Bainem Hospital, Algiers, Algeria.

Kidney transplantation is the best treatment received by an uremic patient. One of the major advantages of transplantation is restoring a hormonal profile as before the chronic kidney disease. However, the posttransplant state depends on several factors including the quality of the graft. Read More

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Primary seminoma of prostate in a patient with Klinefelter syndrome: A case report.

Medicine (Baltimore) 2022 Apr 29;101(17):e29117. Epub 2022 Apr 29.

Department of Urology, Capital Medical University Affiliated Beijing Shijitan Hospital, No. 10 Yangfangdian Road, Haidian District, Beijing, PR China.

Rationale: Klinefelter syndrome (KS) is a sex differentiation syndrome that occurs in men and is characterized by the 47XXY genotype. An association between KS and cancer has also been reported. The occurrence of seminoma of the prostate in KS has not been reported in the literature to date. Read More

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Utility of evaluating semen samples from adolescents with Klinefelter Syndrome for cryopreservation: A multi-institution evaluation.

J Pediatr Urol 2022 Jun 20;18(3):288.e1-288.e5. Epub 2022 Apr 20.

Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.

Introduction: Klinefelter Syndrome (KS) is the most common genetic condition cause of non-obstructive azoospermia (NOA). KS also often results in decreased testicular growth and testosterone production. Because of this, exogenous testosterone therapy is commonly prescribed for KS patients to treat hypogonadism, but this may have additional impacts to future fertility potential. Read More

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Androgens and spermatogenesis.

Ann Endocrinol (Paris) 2022 Jun 27;83(3):155-158. Epub 2022 Apr 27.

Université Paris Saclay, service d'endocrinologie de le reproduction, hôpital Bicêtre, AP-HP, 94275 Bicêtre, France.

Male infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. Read More

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Anti-Müllerian hormone, an ovarian reserve marker in hypogonadotropic hypogonadism.

Eur J Obstet Gynecol Reprod Biol 2022 Jun 21;273:54-58. Epub 2022 Apr 21.

Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Turkey.

Objective: To determine the usefulness of Anti-Müllerian Hormone (AMH) and antral follicle count (AFC) as an ovarian reserve marker in hypogonadotropic hypogonadism (HH) patients and to find a limit value for the gonadotropin levels in the diagnosis of HH patients.

Study Design: It is a retrospective cross-sectional single-center study. One hundred ninety-nine women with HH and 171 healthy controls with no cycle disorders were included into this study. Read More

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Pattern of Male Hypogonadism and Outcome of Treatment in South Rajasthan.

J Assoc Physicians India 2022 Apr;70(4):11-12

Pacific Medical College and Hospital, Udaipur.

Male reproductive functions are governed by hypothalamic pituitary testicular axis. If any component of this axis malfunctions, then hypogonadism will develop which is characterized by ill-defined secondary sexual features and low serum testosterone. The common patterns seen are primary and secondary testicular failure in the young; and late onset hypogonadism in the elderly. Read More

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Defining Reference Ranges for Serum Anti-Müllerian Hormone on a Large Cohort of Normozoospermic Adult Men Highlights New Potential Physiological Functions of AMH on FSH Secretion and Sperm Motility.

J Clin Endocrinol Metab 2022 Jun;107(7):1878-1887

Department of Andrology, Urology and Renal Transplantation, University of Lille, CHU Lille, Lille, France.

Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined in a large cohort.

Objective: In this study, we aimed, first, to establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Second, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters. Read More

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Dilated cardiomyopathy in a cat with congenital hyposomatotropism.

JFMS Open Rep 2022 Jan-Jun;8(1):20551169221086437. Epub 2022 Mar 30.

Division of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland.

Case Summary: A 7-month-old domestic shorthair cat was presented for evaluation of stunted growth, recurrent hypoglycaemia during the first months of its life and altered mentation. Complete blood count and biochemistry were unremarkable, except for mildly elevated serum creatinine concentration (despite low muscle mass) and concurrent isosthenuria. Hyposomatotropism was diagnosed based on persistent low circulating insulin-like growth factor 1 concentrations and a lack of response of circulating growth hormone (GH) concentration after the administration of GH-releasing hormone. Read More

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A rare cause of primary amenorrhea: LHCGR gene mutations.

Eur J Obstet Gynecol Reprod Biol 2022 May 19;272:193-197. Epub 2022 Mar 19.

Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.

Introduction: The luteinizing hormone/choriogonadotropin receptor (LHCGR) plays a critical role in sexual differentiation and reproductive functions in men and women. Inactivating mutations in this gene lead to Leydig cell hypoplasia (LCH), and cause disorders of sex development (DSD) in patients with 46,XY. In this study, it was aimed to discuss the clinical, laboratory and molecular genetic analysis results of nine patients with 46,XY karyotype who had mutations in the LHCGR gene. Read More

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Pilot study on evaluation and determination of the prevalence of Polycystic Ovarian Syndrome (PCOS) associated gene markers in the South Indian population.

Indian J Endocrinol Metab 2021 Nov-Dec;25(6):551-558. Epub 2022 Feb 17.

Department of Molecular Genetics, Alpha Health Foundation, Madurai, Tamil Nadu, India.

Background: Polycystic ovarian syndrome (PCOS) is typically characterized by a spectrum of manifestations that include menstrual irregularities, anovulation, cysts, hyperandrogenic features like hirsutism, acne, alopecia, and various metabolic complications. The pathology of PCOS is complex and several mechanisms have been potentially involved in the genetic abnormalities/dysfunctions. Hence, the present study aims to examine the prevalence and association of polymorphisms in candidate genes (thyroid adenoma-associated gene [THADA], luteinizing hormone and human chorionic gonadotropin receptor [LHCGR], DENN domain containing 1A [DENND1A], follicle-stimulating hormone receptor [FSHR], Connexin37 [CX37], angiotensin-converting enzyme [ACE], insulin receptor [INSR] and calpain 10 [CAPN10]) in PCOS patients of the South Indian regional population. Read More

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February 2022

Phytotherapy of polycystic ovary syndrome: A review.

Int J Reprod Biomed 2022 Jan 18;20(1):13-20. Epub 2022 Feb 18.

Department of Animal Science and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Background: Polycystic ovary syndrome (PCOS) is a complex heterogeneous disease with various symptoms, which can affect females of reproductive age. Endocrine and metabolic abnormalities such as infertility, being overweight or obese, type 2 diabetes, hyperandrogenism and increased luteinizing hormone (LH) are common in women with PCOS.

Objective: This review aimed to assess the efficacy of non-chemical and herbal substances for PCOS recovery. Read More

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January 2022

Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy.

J Clin Endocrinol Metab 2022 Jun;107(7):1983-1993

Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.

Context: Women with Turner syndrome (TS) suffer from hypergonadotropic hypogonadism, causing a deficit in gonadal hormone secretion. As a consequence, these women are treated with estrogen from the age of 12 years, and later in combination with progesterone. However, androgens have been given less attention. Read More

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Testicular biopsy for fertility preservation in early-diagnosed Klinefelter patients: patient characteristics and long-term follow-up.

Reprod Biomed Online 2022 05 3;44(5):889-895. Epub 2022 Feb 3.

Vrije Universiteit Brussel (VUB), Department of Reproduction, Genetics and Regenerative Medicine (RGRG), Biology of the Testis (BITE), Laarbeeklaan 103, Brussels 1090, Belgium.

Research Question: Which early-diagnosed Klinefelter syndrome patients have been offered cryopreservation of testicular tissue as part of fertility preservation before spermatogonial stem cell (SSC) loss? Do these Klinefelter syndrome patients present with behavioural, cognitive and/or psychological problems? Does a testicular biopsy procedure have long-term effects on the gonadal development of Klinefelter syndrome patients?

Design: Early-diagnosed Klinefelter syndrome patients followed between 2009 and 2020 and offered testicular tissue banking in an experimental context at the Universitair Ziekenhuis Brussel were included. The prevalence of behavioural, cognitive and/or psychological problems was determined. Changes in testicular volume and in gonadal function (LH, FSH, testosterone and inhibin B [INHB]) were studied. Read More

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L-Carnitine effect on induced hyperlipidemia on premature rats: fertility profile.

J Med Life 2022 Jan;15(1):124-131

College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.

This study was designed to investigate the effect of hypercholesterolemia on the reproductive performance of premature male rats and to evaluate the influence of L-Carnitine (CAR) in maintaining their fertility. Sixty rats were divided randomly into three groups. Control group (CG n=20 rats), cholesterol feeding group 1 (CFG1 n=20 rats) fed 1. Read More

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January 2022

COVID-19 and Male Reproduction: A Thorny Problem.

Am J Mens Health 2022 Jan-Feb;16(1):15579883221074816

Department of Immunology, Anhui Medical University, Hefei, Anhui, China.

With the global epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the increasing number of infections, little is known about how SARS-CoV-2 affects the male reproductive system during infection or after recovery. Based on the existing research data, we reviewed the effects of SARS-CoV-2 on the male reproductive system and discussed its possible mechanism of action. SARS-CoV-2 enters host cells through the angiotensin-converting enzyme 2 (ACE2)/transmembrane serine protease 2 (TMPRSS2) pathway, and males are more susceptible than females. Read More

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February 2022

Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of fruits.

Pharm Biol 2022 Dec;60(1):282-293

Hormones Department, National Research Centre, Dokki, Egypt.

Context: Forst. (Boraginaceae) has potent pharmacological impact. Meanwhile, its effect on fertility is unclear. Read More

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December 2022

State of hormonal balance in adolescent girls with menstrual function disorders associated with obesity.

J Med Life 2021 Nov-Dec;14(6):834-840

Surgery department No.1, Bukovinian State Medical University, Chernivtsi, Ukraine.

Investigation of the mechanisms promoting the development of menstrual function disorders associated with obesity in adolescent girls is one of the most important issues of modern medicine. This study included 110 patients. 79 patients aged 12-18 with menstrual disorders associated with obesity were divided into two groups: group 1: 46 patients with apparent signs of hyperandrogenism, group 2: 33 patients without clinical manifestations of hyperandrogenism. Read More

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February 2022

First live birth after fertility preservation using vitrification of oocytes in a woman with mosaic Turner syndrome.

J Assist Reprod Genet 2022 Feb 5;39(2):543-549. Epub 2022 Feb 5.

Brussels IVF, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

Purpose: To report the case of a young woman diagnosed with Turner syndrome (TS) who achieved a live birth using her own oocytes that had been vitrified for fertility preservation.

Methods: A 25-year-old woman with mosaic (45,X/46,XX) TS was referred for fertility preservation (FP) counseling. Serum anti-Müllerian hormone (AMH) level was normal (6. Read More

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February 2022

Polycystic Ovary Syndrome Among Female Adolescents With Congenital Adrenal Hyperplasia.

Cureus 2021 Dec 25;13(12):e20698. Epub 2021 Dec 25.

Pediatrics, King Abdulaziz University, Jeddah, SAU.

Objectives: Polycystic ovary syndrome is a common endocrine disease in adolescent females that is usually diagnosed based on clinical and hormonal abnormalities. Female adolescents with poorly controlled congenital adrenal hyperplasia are at increased risk of developing polycystic ovary syndrome. This study aimed to determine the prevalence of polycystic ovary syndrome and assess its relationship with hormonal control among adolescents with congenital adrenal hyperplasia. Read More

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December 2021

Cutaneous Manifestations and Hormonal Changes Among Polycystic Ovary Syndrome Patients at a Tertiary Care Center.

Cureus 2021 Dec 22;13(12):e20593. Epub 2021 Dec 22.

Department of Dermatology, King Abdulaziz Medical City, Western Region, Jeddah, SAU.

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder affecting 5%-10% of women worldwide. PCOS patients usually present with cutaneous manifestations of hyperandrogenism, such as acne, hirsutism, and androgenic alopecia.

Objective: To estimate the prevalence of dermatological manifestations and their association with hormonal changes in PCOS patients. Read More

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December 2021

Effect of obesity on fertility parameters in WIO mice model.

Naif Alsuhaymi

Adv Clin Exp Med 2022 May;31(5):539-546

Department of Emergency Medical Services, College of Health Sciences in Al-Qunfudhah, Umm Al-Qura University, Makkah, Saudi Arabia.

Background: Male infertility is mostly due to low sperm quality, which accounts for about 50% of the causes of infertility. The reasons for low sperm quality are still unclear. Nowadays, many drinks contain high levels of fat, and its effect on fertility is not yet known. Read More

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The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes.

Clin Endocrinol (Oxf) 2022 Jun 29;96(6):837-846. Epub 2022 Jan 29.

Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Context: The previous studies showed that hypogonadotropic hypogonadism (HH) occurred commonly in men with type 2 diabetes. However, since all the cohorts tested were from American and European studies, the occurrence of HH/nongonadal illness (NGI) in Chinese populations is unclear.

Objective: The study aimed to explore the occurrence of HH/NGI in Chinese men with type 2 diabetes. Read More

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FSHB Genotype Identified as a Relevant Diagnostic Parameter Revealed by Cluster Analysis of Men With Idiopathic Infertility.

Front Endocrinol (Lausanne) 2021 21;12:780403. Epub 2021 Dec 21.

Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology (CeRA), University of Münster, Münster, Germany.

Introduction And Objectives: About 30-75% of infertile men are diagnosed with idiopathic infertility, thereby lacking major causative factors to explain their impaired fertility status. In this study, we used a large cohort of idiopathic infertile men to determine whether subgroups could be identified by an unbiased clustering approach and whether underlying etiologic factors could be delineated.

Patients And Methods: From our in-house database Androbase, we retrospectively selected patients (from 2008 to 2018) with idiopathic male infertility (azoo- to normozoospermia) who fit the following selection criteria: FSH ≥ 1 IU/l, testosterone ≥ 8 nmol/l, ejaculate volume ≥ 1. Read More

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February 2022