43,259 results match your criteria Follicle-Stimulating Hormone Abnormalities


Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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December 2018

GLUT3 expression in cystic change induced by hypoxia in pituitary adenomas.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.

Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More

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December 2018
1 Read

Predictive significance of serum inhibin B on testicular haploid gamete retrieval outcomes in nonobstructive azoospermic men.

Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.

Center for Reproductive Medicine, Shandong University, Jinan 250001, China.

The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More

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November 2018

Monosodium Glutamate in the Diet Does Not Raise Brain Glutamate Concentrations or Disrupt Brain Functions.

Authors:
John D Fernstrom

Ann Nutr Metab 2018 3;73 Suppl 5:43-52. Epub 2018 Dec 3.

The non-essential amino acid glutamate participates in numerous metabolic pathways in the body. It also performs important physiologic functions, which include a sensory role as one of the basic tastes (as monosodium glutamate [MSG]), and a role in neuronal function as the dominant excitatory neurotransmitter in the central nervous system. Its pleasant taste (as MSG) has led to its inclusion as a flavoring agent in foods for centuries. Read More

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December 2018

Increasing hypothalamic nucleobindin 2 levels and decreasing hypothalamic inflammation in obese male mice via diet and exercise alleviate obesity-associated hypogonadism.

Neuropeptides 2018 Nov 1. Epub 2018 Nov 1.

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, PR China; School of Kinesiology, Shenyang Sport University, Shenyang, Liaoning 110102, PR China. Electronic address:

To explore the role of nesfatin-1 in regulating male reproductive function during energy balance variation, we employed an obese mouse model which was first induced by a high-fat diet (HFD) and followed by interventions of a normal diet (ND) and/or moderate exercise, and then serum reproductive hormones of male mice, hypothalamic nucleobindin 2 (NUCB2)/nesfatin-1, inflammatory factors, and gonadotropin-releasing hormone (GnRH) levels were tested. Our findings showed that both serum nesfatin-1, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels and hypothalamic NUCB2/nesfatin-1 and Gnrh mRNA levels were reduced, whereas, the mRNA and protein levels of hypothalamic tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, inhibitor kappa B kinase β (IKKβ), and nuclear factor (NF)-κB were increased in obese male mice. Diet, exercise, and diet combined with exercise interventions reversed the decreases in serum nesfatin-1, FSH, LH, and T levels; increased hypothalamic NUCB2/nesfatin-1 and Gnrh mRNA levels; and reduced hypothalamic TNF-α, IL-1β, IKKβ, and NF-κB levels. Read More

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November 2018

The impact of using donor sperm in assisted reproductive technology cycles on perinatal outcomes.

Fertil Steril 2018 Dec;110(7):1285-1289

Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; Montefiore's Institute for Reproductive Medicine and Health, Hartsdale, New York.

Objective: To assess the impact of using donor sperm in assisted reproductive technology (ART) cycles on perinatal outcomes.

Design: Historical cohort study.

Setting: US national database from the Society of Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 2012 to 2013. Read More

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December 2018

Ovarian Function In Adolescents Conceived By Assisted Reproductive Technologies.

J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Maternal and Child Research, School of Medicine, University of Chile.

Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).

Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.

Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More

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November 2018

Endometrial but not Ovarian Response is Associated With Clinical Outcomes and can be Improved by Prolonged Pituitary Downregulation in Patients With Thin and Medium Endometrium.

Reprod Sci 2018 Dec 3:1933719118816835. Epub 2018 Dec 3.

1 Reproductive Medicine Centre, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, China.

The aim of this study is to investigate the effect of ovarian and endometrial response on live birth rates (LBRs) in young normal and high responders and prolonged pituitary downregulation on endometrial receptivity and clinical outcomes in patients with different endometrial thickness. Between January 2013 and December 2017, 9511 patients underwent first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles with age ≤35 years, follicle stimulating hormone < 10 IU/l, and ≥4 retrieved oocytes were conducted. The estradiol (E) levels on the human chorionic gonadotropin (HCG) day were classified into 4 groups: group 1 (<3000 pg/mL); group 2 (3000-5000 pg/mL); group 3 (5000-7000 pg/mL), and group 4 (≥7000 pg/mL). Read More

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December 2018

Ovarian reserve in adolescent girls born prematurely.

Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.

Regional Children's Clinical Hospital, Kemerovo, Russia.

Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More

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December 2018
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Histone deacetylase inhibitors suppress transdifferentiation of gonadotrophs to prolactin cells and proliferation of prolactin cells induced by diethylstilbestrol in male mouse pituitary.

Histochem Cell Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Diethylstilbestrol (DES), an estrogen agonist, increases prolactin (PRL) cells through transdifferentiation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells to PRL cells as well as proliferation of PRL cells in adult male mouse pituitary. Since hyperacetylation of histone H3 is implicated in the regulation of activation of various genes, we examined the effect of DES on the state of histone H3 acetylation. DES significantly reduced the immunohistochemical signal for acetylated histone H3 at lysine 9 (H3K9ac) in PRL, LH and FSH cells, but not for H3K18ac or H3K23ac. Read More

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December 2018
1 Read

Seasonal expressions of luteinising hormone receptor, follicle-stimulating hormone receptor and prolactin receptor in the epididymis of the male wild ground squirrel (Spermophilus dauricus).

Reprod Fertil Dev 2018 Dec 4. Epub 2018 Dec 4.

Luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) are pituitary-derived hormones and mediate their functions through LH receptor (LHR), FSH receptor (FSHR) and PRL receptor (PRLR) respectively. This study aimed to investigate the seasonal expression patterns of LHR, FSHR and PRLR in the epididymis of the male wild ground squirrel during the breeding and non-breeding seasons. Histologically, principal cells, basal cells, cilia and mature spermatozoa were found in the lumen of caput, corpus and cauda epididymidis in the breeding season, whereas in the non-breeding season, cilia and basal cells were rarely found and the epididymidal duct was devoid of spermatozoa. Read More

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December 2018

Evolution of the regulatory mechanism for hypothalamic-pituitary-gonadal axis in vertebrates - hypothesis from a comparative view.

Authors:
Shinji Kanda

Gen Comp Endocrinol 2018 Nov 27. Epub 2018 Nov 27.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

Reproduction is regulated by the hypothalamic-pituitary-gonadal axis (HPG) in vertebrates. In addition to wealth of knowledge in mammals, recent studies in non-mammalian species, especially teleosts, have provided evidence that some of the components in the HPG axis are conserved in bony vertebrates. On the other hand, from the comparisons of the recent accumulating knowledge between mammals and teleosts, unique characteristics of the regulatory system in each group have been unveiled. Read More

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November 2018

Associations between biochemical components of human semen with seminal conditions.

Syst Biol Reprod Med 2018 Nov 30:1-9. Epub 2018 Nov 30.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

The aim of the study was to assess whether abnormal levels of seminal biochemical components could be associated with semen alterations and infertility. In this study, 92 human ejaculates from selected men were analyzed. Albumin, estradiol, ferritin, total proteins (TP), folic acid (FA), vitamin B12, alkaline phosphatase (ALP), creatine kinase (CK), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase were evaluated. Read More

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November 2018

Pediatric silent corticotroph pituitary adenoma and role for proton therapy: case report.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-5. Epub 2018 Nov 1.

Tumors involving the sella are commonly craniopharyngiomas, optic pathway gliomas, or pituitary adenomas. Functioning adenomas are expected, with prolactinomas topping the differential. The authors present the case of a silent corticotroph adenoma, which has not been described in the pediatric population, and they detail the use of proton therapy, which is also novel. Read More

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November 2018

Follicle-stimulating hormone, but not cardiorespiratory fitness, is associated with flow-mediated dilation with advancing menopausal stage.

Menopause 2018 Nov 26. Epub 2018 Nov 26.

Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA.

Objective: The aim of the study was to evaluate if there are differences in endothelial function before and after acute exercise in women at different menopausal stages with high and low cardiorespiratory fitness.

Methods: Participants were healthy high-fit premenopausal (n = 11), perimenopausal (n = 12), and postmenopausal women (n = 13) and low-fit perimenopausal (n = 7) and postmenopausal women (n = 8). Brachial artery flow-mediated dilation (FMD) was measured before and after acute moderate intensity exercise. Read More

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November 2018

Perfluorododecanoic acid blocks rat Leydig cell development during prepuberty.

Chem Res Toxicol 2018 Nov 29. Epub 2018 Nov 29.

Perfluorododecanoic acid (PFDoA) has been used as a surfactant and may have reproductive toxicity. However, whether PFDoA influences Leydig cell development during prepuberty remains unknown. In the present study, 21-day-old male Sprague Dawley rats were gavaged 0, 5 or 10 mg/kg PFDoA from postnatal day 21 to 35. Read More

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November 2018
2 Reads

HDAC inhibitors impair Fshb subunit expression in murine gonadotrope cells.

J Mol Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

D Bernard, Pharmacology and Therapeutics, McGill University , Montreal, H3G 1Y6, Canada.

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. Read More

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November 2018

Bi-allelic recessive loss-of-function mutations in FIGLA cause premature ovarian insufficiency with short stature.

Clin Genet 2018 Nov 25. Epub 2018 Nov 25.

IVF Center, Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Premature ovarian insufficiency (POI) is a group of heterogeneous disorders characterized by decreased ovarian reserve and increased follicle stimulating hormone (FSH) levels. It is rarely associated with short stature. FIGLA mutations with POI are identified with regards to heterozygosity; till date, only one affected family has been identified with homozygous mutations in FIGLA but without functional evaluation. Read More

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November 2018
1 Read

The pregnancy outcomes of intrauterine insemination with husband's sperm in natural cycles versus ovulation stimulated cycles: A retrospective study.

Biosci Trends 2018 ;12(5):463-469

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

To compare the clinical outcomes of intrauterine insemination (IUI) with or without ovulation induction (OI), IUI cycles from January 2008 to December 2017 in Zhoushan Maternity and Child Healthcare Hospital were included, consisting of 455 natural cycles and 536 OI cycles. The overall clinical pregnancy rate did not differ between the two groups (P > 0.05). Read More

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January 2018
4 Reads

Effect of intra-ovarian injection of mesenchymal stem cells in aged mares.

J Assist Reprod Genet 2018 Nov 23. Epub 2018 Nov 23.

Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843-4466, USA.

Purpose: This study aims to determine if intra-ovarian injection of bone marrow-derived mesenchymal stem cells (MSCs) improves or restores ovarian function in aged females.

Methods: Prospective randomized study of eight aged mares and six young mares receiving intra-ovarian injection of MSCs or vehicle. Main outcome measures were antral follicle count and serum anti-Müllerian hormone (AMH) (aged and young mares), and for aged mares, oocyte meiotic and developmental competence; gross and histological ovarian assessment; evaluation of presence of chimerism in recovered granulosa cells and in ovarian tissue samples; and gene expression in ovarian tissue as assessed by RNA sequencing. Read More

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November 2018
2 Reads

Safety concerns of biosimilar hormone products.

Curr Med Res Opin 2018 Nov 23:1-14. Epub 2018 Nov 23.

c Takeda Pharmaceuticals.

Currently, biotherapeutic medicines are the most effective options for the treatment of many severe and chronic diseases. For faster market entry of biotherapeutic products and their cost reduction, the principles of "biosimilarity" have been developed. Development and licensing of biosimilars is allowed only after the end of patent exclusivity of the original preparation period. Read More

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November 2018

Immunization against Kisspeptin-54 perturb hypothalamic-pituitary-testicular signaling pathway in ram lambs.

Theriogenology 2018 Nov 6;125:193-202. Epub 2018 Nov 6.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, People's Republic of China.

Kisspeptin, a peptide product of KISS1 gene, recently identified as essential upstream gatekeeper in hypothalamic-pituitary-gonadal (HPG) axis. This study was designed to investigate the effect of immunization against kisspeptin-54 on hypothalamic-pituitary-testicular signaling pathway. A total of ten intact 56-days-old ram lambs were used and randomized into the treatment and control groups, which were, respectively immunized by kisspeptin-54 based vaccine and the empty plasmid via intramuscular route. Read More

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November 2018
8 Reads

Total flavonoids extracted from  in the treatment of polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway.

Biosci Rep 2018 Nov 21. Epub 2018 Nov 21.

Colleage of Public Health, Guilin Medical University, Guilin, China

Large doses of flavonoids could cure many diseases with no serious side effects. However, the role of flavonoids in the treatment of polycystic ovary syndrome (PCOS) has not been reported. Therefore, total flavonoids extracted from were selected to explore its therapeutic efficiency in PCOS. Read More

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November 2018
3 Reads

Molecular dynamics simulation of the follicle-stimulating hormone receptor. Understanding the conformational dynamics of receptor variants at positions N680 and D408 from in silico analysis.

PLoS One 2018 21;13(11):e0207526. Epub 2018 Nov 21.

Red de Apoyo a la Investigación, National University of Mexico (UNAM) and Instituto Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, Mexico.

Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs. Structural data of the FSHR ectodomain in complex with follicle-stimulating hormone suggests a "pull and lift" activation mechanism that triggers a conformational change on the seven α-helix transmembrane domain (TMD). To analyze the conformational changes of the FSHR TMD resulting from sequence variants associated with reproductive impairment in humans, we set up a computational approach combining helix modeling and molecular simulation methods to generate conformational ensembles of the receptor at room (300 K) and physiological (310 K) temperatures. Read More

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November 2018
2 Reads

Influence of follicle-stimulating hormone concentrations on the integrity and development of bovine follicles cultured in vitro.

Zygote 2018 Oct 21;26(5):417-423. Epub 2018 Nov 21.

1Laboratory of Animal Reproduction,University of Londrina (UEL),Paraná, 86051-990, Cx. Postal: 10.011,Brazil.

SummaryThis study investigated the in vitro culture of bovine follicles included in ovarian tissue for 2 or 6 days (D2 or D6), with the addition of different concentrations of follicle-stimulating hormone (FSH) (0, 10, 50, 100 or 200 ng/ml). Data were compared for follicular development, morphological integrity and diameter of follicles and oocytes. Ovaries (n = 10) from Nelore cows (n = 5) were divided into fragments (n = 11 per ovary) and were immediately fixed in Bouin's solution (D0) or were individually cultured for 2 or 6 days in one of the described concentrations of FSH and then processed for histology. Read More

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October 2018

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

Eur J Nutr 2018 Nov 20. Epub 2018 Nov 20.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

Purpose: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.

Methods: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. Read More

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November 2018
1 Read

Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling.

Front Endocrinol (Lausanne) 2018 2;9:653. Epub 2018 Nov 2.

Department Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom.

Models of G protein-coupled receptor (GPCR) signaling have dramatically altered over the past two decades. Indeed, GPCRs such as the follicle-stimulating hormone receptor (FSHR) have contributed to these new emerging models. We now understand that receptor signaling is highly organized at a spatial level, whereby signaling not only occurs from the plasma membrane but distinct intracellular compartments. Read More

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November 2018
2 Reads

Sport, doping and female fertility.

Reprod Biol Endocrinol 2018 Nov 19;16(1):108. Epub 2018 Nov 19.

Department of Clinical and Experimental Medicine, University of Catania, Policlinico "G. Rodolico", via S. Sofia 78, 95123, Catania, Italy.

This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes concerning the serum concentrations of follicle-stimulating hormone, luteinizing hormone, prolactin, growth hormone, thyroid hormones, leptin, ghrelin, neuropeptide Y. The second paragraph analyzes the effects of doping on the hypothalamic-pituitary-ovarian axis. Read More

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November 2018
2.410 Impact Factor

Short-term effects of surgical weight loss after sleeve gastrectomy on sex steroids plasma levels and PSA concentration in men with severe obesity.

Aging Male 2018 Nov 17:1-5. Epub 2018 Nov 17.

a Clinica Medica 3, Department of Medicine - DIMED, School of Medicine , University of Padova , Via Giustiniani 2 , Padova , Italy.

Male obesity is known to be associated with hypogonadism, which can be reverted after surgical weight reduction. However, the evidence about how rapidly this effect rises after surgery and what consequences each procedure have on prostate function and prostatic-specific antigen (PSA) concentration is scarce. So, we evaluated total testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone and PSA plasma levels in a group of 29 Caucasian obese men (BMI - 43. Read More

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November 2018
2 Reads

Impact of Chemotherapy-induced Menopause in Women of Childbearing Age With Non-metastatic Breast Cancer - Preliminary Results From the MENOCOR Study.

Clin Breast Cancer 2018 Oct 23. Epub 2018 Oct 23.

Université Clermont Auvergne, Centre Jean Perrin, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont-Ferrand, France.

Background: Young patients with breast cancer treated with chemotherapy can experience ovarian failure, which can lead to chemotherapy-induced menopause (CIM) impacting the quality of life (QoL). A prospective study was set out to evaluate the impact of CIM on QoL in women of childbearing age with non-metastatic breast cancer, and this article reports results of the interim analysis conducted to evaluate feasibility and to see preliminary results.

Patients And Methods: A total of 58 women (age, 18-46 years) with newly diagnosed breast cancer and treated with chemotherapy were eligible. Read More

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October 2018
3 Reads

The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.

Reprod Toxicol 2018 Nov 14;83:28-37. Epub 2018 Nov 14.

Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Ministry of Education Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China. Electronic address:

Background: Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. Read More

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November 2018
3 Reads

Intraoperative assessment of tubules in predicting microdissection testicular sperm extraction outcome in men with Sertoli cell-only syndrome.

J Int Med Res 2018 Nov 15:300060518809257. Epub 2018 Nov 15.

Centre for Reproductive Medicine and Prenatal Diagnosis, First Hospital of Jilin University, Changchun, Jilin Province, China.

Objective: This study aimed to assess the value of measuring the tubule diameter during microdissection testicular sperm extraction (micro-TESE) in predicting outcomes in patients with Sertoli cell-only syndrome (SCOS).

Methods: Fifty-six consecutive patients with SCOS were included. Patients were classified into two groups on the basis of the diameter of seminiferous tubules measured against 5/0 surgical suture (≥100 µm or <100 µm). Read More

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November 2018

Label-free Paper-based Immunosensor with Graphene Nanocomposites for Electrochemical Detection of Follicle-stimulating Hormone.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2901-2904

Follicle-stimulating hormone (FSH) is an important indicator of ovarian reserve function in women in clinical testing. In this work, a label-free paper-based immunosensor was developed for electrochemical rapid detection of FSH. A hydrophilic channel surrounded with hydrophobic barriers was firstly fabricated on the chromatography paper by wax printing technology. Read More

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Modulatory effects of methanolic fruit fraction of Pedalium murex on sulphasalazine-induced male reproductive disruption.

Andrologia 2018 Nov 14:e13190. Epub 2018 Nov 14.

Reproductive Physiology and Endocrinology Section, Centre of Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India.

Pedalium murex is widely practiced in Ayurveda for the treatment of sexual disorders, but their detailed scientific evaluations are still unexplored. Therefore, the present study was conducted to assess the effect of methanolic fruit fraction of P. murex (MfPm) against sulphasalazine (SSZ) induced male reproductive disruption. Read More

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November 2018
6 Reads

Delayed Puberty by Ziram Is Associated with Down Regulation of Testicular Phosphorylated AKT1 and SIRT1/PGC-1α Signaling.

Chem Res Toxicol 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 109 Xueyuan West Road , Wenzhou , Zhejiang 325027 , China.

Ziram is a dimethyldithiocarbamate fungicide, which may influence the male reproductive system as a potential endocrine disruptor. We interrogated the disruption of ziram on rat progenitor Leydig cell development. Prepubertal male Sprague-Dawley rats were orally treated with 0, 2, 4, or 8 mg/kg ziram for 2 weeks. Read More

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November 2018
4 Reads
3.530 Impact Factor

Early luteal development in Santa Inês ewes superovulated with reduced doses of porcine follicle-stimulating hormone.

Reprod Domest Anim 2018 Nov 12. Epub 2018 Nov 12.

Faculdade de Ciências Agrárias e Veterinárias, UNESP-Universidade Estadual Paulista, Jaboticabal, Brazil.

The aim was to compare the early luteal development in ewes superovulated with different doses of pFSH. Twenty-nine Santa Inês ewes received a progesterone device (CIDR®) for 8 days. Gonadotrophic treatment started on Day 6: G200 (control, n = 9, 200 mg); G133 (n = 10, 133 mg); and G100 (n = 10, 100 mg of pFSH). Read More

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November 2018
1 Read

Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling.

Methods Mol Biol 2018 ;1819:405-429

Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol, UK.

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes. These are G-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. FSH and LH control steroidogenesis and gametogenesis in the gonads so GnRH mediates control of reproduction by the central nervous system. Read More

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January 2018
1 Read

Bitter taste receptor ligand improves metabolic and reproductive functions in a murine model of PCOS.

Endocrinology 2018 Nov 9. Epub 2018 Nov 9.

Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Endocrinology, Baltimore, MD.

Polycystic ovary syndrome (PCOS) results from functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Cultured theca cells from polycystic ovaries of women with the most common form of PCOS overexpress most androgen producing enzymes, particularly CYP450c17. This study used a murine model of PCOS induced by chronic feeding with high fat content diet that exhibits the reproductive, hyperandrogenic, and metabolic constellation of symptoms of PCOS seen in women. Read More

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November 2018
6 Reads

Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.

J Clin Transl Endocrinol 2018 Dec 26;14:25-33. Epub 2018 Sep 26.

Department of Medical Endocrinology and Metabolism, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark.

Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH concentrations can be normal or even above the upper normal reference limit. Indeed, certain patients are at risk of developing CH, such as those with a pituitary adenoma or hypophysitis, those who have been treated for a childhood malignancy, have suffered a head trauma, sub-arachnoid hemorrhage or meningitis, and those who are on drugs capable to reduce TSH secretion. Read More

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December 2018
4 Reads

Risk assessment of endocrine disrupting phthalates and hormonal alterations in children and adolescents.

J Toxicol Environ Health A 2018 12;81(21):1150-1164. Epub 2018 Nov 12.

a Division of Toxicology , College of Pharmacy, Sungkyunkwan University , Suwon , Gyeonggi-do , South Korea.

Risk assessment and hormone evaluation were carried out for di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), endocrine disrupting chemicals (EDCs), in 302 Korean children (n = 223) and adolescents (n = 79) (< age 19). Urinary and serum concentrations of DEHP, MEHP (mono(2-ethylhexyl) phthalate), DBP, MBP (monobutyl phthalate), and PA (phthalic acid, a common final metabolite of phthalates) were detected in children and adolescents. Daily exposure levels were estimated to be 16. Read More

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November 2018

Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.

Life Sci 2018 Nov 7. Epub 2018 Nov 7.

Guangdong Engineering & Technology Research Center for Disease-Model Animals, Program in Cardiovascular Disease and Metabolism, the Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Laboratary Animal Center, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. Electronic address:

Aims: This study aims to investigate the pathophysiological role and mechanism of pigment epithelium-derived factor (PEDF) deletion in ovarian damage.

Methods: Female PEDF-knockout mice and their wild-type littermates were used in this study. Relevant tests were performed at 8-10 weeks or 32 weeks of age. Read More

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November 2018
6 Reads

Androgen receptor gene mutations are associated with male infertility in Northeast China: Clinical features and identification of two novel mutations.

Andrologia 2018 Nov 8:e13195. Epub 2018 Nov 8.

Peking Medriv Academy of Genetics and Reproduction, Peking, China.

The purpose of this study was to investigate the prevalence of androgen receptor gene mutations in idiopathic male infertility in north-east China and to analyse the relationship between genotype and phenotype. Cohorts of 400 male patients with idiopathic infertility and 200 fertile controls were recruited. Clinical investigations were carried out by experienced andrologists. Read More

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November 2018
3 Reads

Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes.

Int J Gynaecol Obstet 2018 Nov 8. Epub 2018 Nov 8.

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objective: To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.

Methods: A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS. Read More

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November 2018
2 Reads

Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports.

Case Rep Obstet Gynecol 2018 15;2018:9294650. Epub 2018 Oct 15.

Department of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, Turkey.

Development of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent years, some follicle-stimulating hormone (FSH) receptor (FSHR) gene mutations have been described in patients with OHSS in the first trimester with normal hCG levels. Read More

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October 2018
2 Reads

Current and emerging medical therapeutic agents for idiopathic male infertility.

Expert Opin Pharmacother 2018 Nov 8:1-13. Epub 2018 Nov 8.

a Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.

Introduction: Infertility is one of the great challenges of modern healthcare. It afflicts about 8-12% of reproductive-aged couples worldwide, but the prevalence is even higher in industrialized countries. In 50% of cases, a male factor of infertility underlies the problem, but in about 30% of these cases the etiology of male infertility remains unknown. Read More

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November 2018
12 Reads
3.530 Impact Factor

Could polymorphisms of some hormonal receptor genes, involved in folliculogenesis help in predicting patient response to controlled ovarian stimulation?

J Assist Reprod Genet 2018 Nov 8. Epub 2018 Nov 8.

Department of Reproductive Medicine and Gynecological Endocrinology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

Purpose: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in selected genes, responsible for hormonal regulation of folliculogenesis, are associated with response to controlled ovarian hyperstimulation (COH) and clinical characteristics of women enrolled in in vitro fertilization (IVF) programs.

Methods: In a cross-sectional study, 60 (IVF) patients underwent COH by using gonadotropin-releasing hormone (GnRH) antagonist and recombinant follicle-stimulating hormone (rFSH) protocol. Patients were classified into three groups: poor-responders (according to Bologna criteria), normo-responders (≤ 15 oocytes), and hyper-responders (> 15 oocytes). Read More

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November 2018

Randomized, Double-Blind, Placebo-Controlled Study of Modified Erzhi Granules in the Treatment of Menopause-Related Vulvovaginal Atrophy.

Evid Based Complement Alternat Med 2018 14;2018:6452709. Epub 2018 Oct 14.

Tianjin University of Traditional Chinese Medicine, China.

Objective: To evaluate the clinical therapeutic efficacy and safety of modified Erzhi granules (MEG) in patients with menopause-related vulvovaginal atrophy (VVA).

Methods: This randomized, double-blind, placebo-controlled study comprised two groups, including the treatment and control groups. Patients receive MEG and placebo for 12 weeks, respectively. Read More

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October 2018
6 Reads
1.880 Impact Factor

Bu Shen Yang Xue Prescription Has Treating Effect on Endometrial Cancer through FSH/PI3K/AKT/Gankyrin/HIF-/cyclinD 1 Pathway in Ishikawa Cells.

Evid Based Complement Alternat Med 2018 9;2018:8412984. Epub 2018 Oct 9.

Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China.

The formulation of Bu Shen Yang Xue (BSYX) has been clinically used in treating gynecologic disease in China, especially for the development of the endometrium. Endometrial carcinoma is the most common malignant tumor of the female genital tract in developed countries. And few studies have been reported on the antitumor activity of BSYX. Read More

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October 2018
4 Reads

Cardiovascular Implications of the Menopause Transition: Endogenous Sex Hormones and Vasomotor Symptoms.

Obstet Gynecol Clin North Am 2018 Dec 25;45(4):641-661. Epub 2018 Oct 25.

Departments of Psychiatry and Epidemiology, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.

The menopause transition (MT) is a critical period of women's lives marked by several physiologic changes and menopause-related symptoms that have implications for health. Risk for cardiovascular disease, the leading cause of death in women, increases after menopause, suggesting a contribution of the MT to its development. This article focuses on the relationship between 2 main features of the MT and women's cardiovascular health: (1) dynamic alterations of sex hormones, particularly endogenous estradiol and follicle-stimulating hormone, and (2) vasomotor symptoms, the cardinal symptom of the menopause. Read More

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December 2018
3 Reads