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    2829 results match your criteria Follicle-Stimulating Hormone Abnormalities

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    Ovarian Reserve in Young Juvenile Idiopathic Arthritis Patients.
    Mod Rheumatol 2018 Apr 13:1-14. Epub 2018 Apr 13.
    a Pediatric Rheumatology Unit , Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo , Sao Paulo , BR.
    Objectives: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are not systematic data regarding ovarian function in this disease.

    Methods: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL). Read More

    Protective potential of royal jelly against cadmium-induced infertility in male rats.
    Andrologia 2018 Mar 12. Epub 2018 Mar 12.
    Department of Biochemistry, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
    This study aimed to investigate the protective potential of Royal jelly (RJ) against cadmium (Cd)-induced testicular dysfunction in rats. Thirty-five adult male Wistar rats were assigned into five groups. G I; (control) injected intraperitoneally with saline, G II injected intraperitoneally with a single dose of CdCl (1 mg/kg BW), G III received RJ (100 mg/kg BW/day) orally, G IV was pre-treated with RJ for 1 week then, treated with CdCl , and G V was co-treated with RJ and CdCl . Read More

    Artificial Neural Network for the Prediction of Chromosomal Abnormalities in Azoospermic Males.
    Urol J 2018 Feb 4. Epub 2018 Feb 4.
    Department of Urology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Purpose: To evaluate whether an artifical neural network helps to diagnose any chromosomal abnormalities in azoospermic males.

    Materials And Methods: The data of azoospermic males attending to a tertiary academic referral center were evaluated retrospectively. Height, total testicular volume, follicle stimulating hormone, luteinising hormone, total testosterone and ejaculate volume of the patients were used for the analyses. Read More

    Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes.
    Int J Fertil Steril 2018 Apr 7;12(1):72-80. Epub 2018 Jan 7.
    Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India. Electronic address:
    Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats.

    Materials And Methods: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals. Read More

    Female Offspring From Chronic Hyperandrogenemic Dams Exhibit Delayed Puberty and Impaired Ovarian Reserve.
    Endocrinology 2018 02;159(2):1242-1252
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Female offspring of many species exposed to high doses of androgens in utero experience endocrine dysfunction during adulthood. The phenotype of offspring from females with prepregnancy hyperandrogenemia and impaired ovulation, however, has not been examined. We developed a mouse model of hyperandrogenemia by implanting a low-dose dihydrotestosterone (DHT) pellet 15 days before conception. Read More

    Omega-3 fatty acids supplementation with lithium and aripiprazole for improving the balance of circulating hormones and brain neurotransmitters in manic mice model.
    Naunyn Schmiedebergs Arch Pharmacol 2018 Mar 30;391(3):335-346. Epub 2017 Dec 30.
    Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
    The present study was designed to evaluate the combined effect of lithium and aripiprazole supplemented with omega-3 fatty acids in methylphenidate (MPD)-induced manic mice. Swiss albino mice were administered with MPD or saline for 14 days, and based on changes in behavioral activities animals were treated with lithium, aripiprazole, and omega-3 fatty acids from the 8th day. Behavioral patterns were analyzed by video tracking. Read More

    Effects of the insulin-like growth factor system on testicular differentiation and function: a review of the literature.
    Andrology 2018 Jan 1;6(1):3-9. Epub 2017 Dec 1.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    We recently described the occurrence of cryptorchidism, oligoasthenoteratozoospermia, and genital abnormalities in patients with distal 15q chromosome structural abnormalities. This observation brought us to hypothesize that insulin-like growth factor (IGF) receptor (IGF1R), mapping on the 15q 26.3 chromosomal band, may be involved in testicular function. Read More

    Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis.
    Toxicol Sci 2018 Mar;162(1):318-326
    Department of Medicine Cardiology Division, School of Medicine, University of Maryland, Baltimore, Maryland 21210.
    Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2. Read More

    Roles of Hypothalamic-Pituitary-Adrenal Axis and Hypothalamus-Pituitary-Ovary Axis in the Abnormal Endocrine Functions in Patients with Polycystic Ovary Syndrome.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Oct;39(5):699-704
    Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences,Fujian Normal University,Fuzhou 350007,China.
    Polycystic ovary syndrome(PCOS) is a common reproductive endocrine disease in women of childbearing age. While it can be affected by a variety of factors,its pathophysiology remains unclear. Its clinical features mainly include anovulation,hyperandrogenism,and hyperinsulinemia,which are closely related with abnormal neuroendocrine system. Read More

    Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.
    Handb Exp Pharmacol 2018 ;245:1-39
    Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA.
    Gonadotropin receptors belong to the highly conserved subfamily of the G protein-coupled receptor (GPCR) superfamily, the so-called Rhodopsin-like family (class A), which is the largest class of GPCRs and currently a major drug target. Both the follicle-stimulating hormone receptor (FSHR) and the luteinizing hormone/chorionic gonadotropin hormone receptor (LHCGR) are mainly located in the gonads where they play key functions associated to essential reproductive functions. As any other protein, gonadotropin receptors must be properly folded into a mature tertiary conformation compatible with quaternary assembly and endoplasmic reticulum export to the cell surface plasma membrane. Read More

    Olfactory bulb agenesis with normal sexual hormones.
    BMJ Case Rep 2017 Oct 11;2017. Epub 2017 Oct 11.
    Department of Medicine, Bumrungrad International Hospital, Bangkok, Thailand.
    An 18-year-old Caucasian man presented with a lack of sense of surrounding smell. The problem was first noticed when a family member discussed the smell of the food, which he had no idea what it was. The patient had normal development and sexual function, no history of trauma, surgery, chemical exposure or infection. Read More

    Pooled analysis of menstrual irregularities from three major clinical studies evaluating everolimus for the treatment of tuberous sclerosis complex.
    PLoS One 2017 12;12(10):e0186235. Epub 2017 Oct 12.
    Royal Sussex County Hospital, Brighton, United Kingdom.
    Objectives: To determine the impact of everolimus on female fertility, including menstrual irregularities, secondary amenorrhea, and luteinizing and follicle stimulating hormone levels in female patients.

    Design: A pooled analysis from 3 prospective studies consisting of a core phase (≥6 months) and a long-term follow-up open-label extension.

    Setting: One phase 2 single-center and two phase 3 multicenter studies. Read More

    The Genetic Basis of Delayed Puberty.
    Neuroendocrinology 2018 18;106(3):283-291. Epub 2017 Sep 18.
    The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density, and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Read More

    Reconsidering a Lower Level of Follicle-Stimulating Hormone as Abnormal in Sub-Fertile Males of Pakistan.
    J Coll Physicians Surg Pak 2017 Aug;27(8):466-469
    Department of Obstetrics and Gynecology Unit 1, Civil Hospital, Karachi.
    Objective: To assess the association between Follicle-Stimulating Hormone (FSH) and semen parameters in order to evaluate whether the current laboratory reference for abnormal FSH levels should be readjusted.

    Study Design: Observational, cross-sectional study.

    Place And Duration Of Study: Infertility Clinic of Gynecology Unit 1, Civil Hospital, Karachi, from May 2015 to April 2016. Read More

    A recurrent synonymous mutation in the human androgen receptor gene causing complete androgen insensitivity syndrome.
    J Steroid Biochem Mol Biol 2017 11 22;174:14-16. Epub 2017 Jul 22.
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Androgen insensitivity syndrome (AIS) is the most common cause of 46,XY disorders of sex development (46,XY DSD). This syndrome is an X-linked inheritance disease and it is caused by mutations in the human androgen receptor (AR) gene. Non-synonymous point AR mutations are frequently described in this disease, including in the complete phenotype. Read More

    Impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in premenopausal HIV infected females at NAUTH, Nnewi, Nigeria.
    PLoS One 2017 19;12(7):e0176361. Epub 2017 Jul 19.
    Depatment of Community Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra, State Nigeria.
    Background: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria.

    Methods: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi. They were all premenopausal females with regular menstrual cycle and aged between 15-45 years. Read More

    Laparoscopically Removed Streak Gonad Revealed Gonadoblastoma in Frasier Syndrome.
    Anticancer Res 2017 07;37(7):3975-3979
    Department of Pathology, Faculty of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
    Background: Frasier syndrome (FS) is characterized by gonadal dysgenesis and progressive nephropathy caused by mutation in the Wilm's tumor gene (WT1). We report a case of FS in which diagnosis was based on amenorrhea with nephropathy, and laparoscopically-removed streak gonad which revealed gonadoblastoma.

    Case Report: At the age of 3 years, the patient developed nephrotic syndrome. Read More

    Mild androgen insensitivity syndrome (MAIS): the identification of c.1783C>T mutation in two unrelated infertile men.
    BMJ Case Rep 2017 Jun 28;2017. Epub 2017 Jun 28.
    Department of Reproductive Medicine, Genetics and Embryology, Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
    Two unrelated men complaining of primary male infertility presented to Orient Hospital in Damascus city. Physical examination showed moderate hypoandrogenic features. Both men were azoospermic. Read More

    Di-n-butyl phthalate prompts interruption of spermatogenesis, steroidogenesis, and fertility associated with increased testicular oxidative stress in adult male rats.
    Environ Sci Pollut Res Int 2017 Aug 24;24(22):18563-18574. Epub 2017 Jun 24.
    Department of Zoology, Sri Venkateswara University, Tirupati, 517 502, India.
    Di-n-butyl phthalate (DBP) is extensively used as plasticizer, and it was ubiquitary released into the environment. The present study was aimed to investigate the effect of DBP on reproductive competence in adult male rats. Adult male rats were received corn oil or DBP injection intraperitoneally (ip) at 100 and 500 mg/kg body weight on 90, 97, 104, and 111 days. Read More

    A child with hypertension and ambiguous genitalia - an uncommon variant of congenital adrenal hyperplasia: a case report.
    J Med Case Rep 2017 Jun 23;11(1):168. Epub 2017 Jun 23.
    Department of Biochemistry, Institute of Medicine (IOM), Kathmandu, Nepal.
    Background: Deficiency in 11β-hydroxylase as a cause of congenital adrenal hyperplasia is uncommon. It should be considered in the differential diagnosis of hypertension with virilization in any prepubescent child.

    Case Presentation: A 12-year-old Asian boy from eastern Nepal presented with pain in his abdomen and hypertension. Read More

    AR mutations in 28 patients with androgen insensitivity syndrome (Prader grade 0-3).
    Sci China Life Sci 2017 Jul 14;60(7):700-706. Epub 2017 Jun 14.
    Beijing Key Laboratory for Genetics of Birth Defects, Center of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, The Capital Medical University, National center for children's health, Beijing, 100045, China.
    We investigated the androgen receptor (AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome (AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes (Prader grade 0-3). Patients and some family members were screened via amplification and sequencing of their AR exons 1-8, including the corresponding intronic flanking regions. Read More

    Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis.
    J Pediatr Endocrinol Metab 2017 May;30(5):561-568
    Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago.
    Background: During puberty there is a physiologic increase in adrenal and ovarian androgens. It has been suggested that the somatotrophic axis may be related to the development of hyperandrogenism and anovulation in non-obese adult women with polycystic ovarian syndrome (PCOS). The objective of the study was to investigate whether ovarian androgen secretion in young postmenarchal girls is related to the function of their somatotropic axis. Read More

    Peutz-Jeghers syndrome with early onset of pre-adolescent gynecomastia: a predigree case report and clinical and molecular genetic analysis.
    Am J Transl Res 2017 15;9(5):2639-2644. Epub 2017 May 15.
    Department of Endocrine, Shenzhen Children's HospitalNo. 7019 Yitian Road, Futian District, Shenzhen 518000, Guangdong, China.
    This study reports a case of Peutz-Jeghers syndrome with early onset of gynecomastia, and discusses its clinical characteristics and genetic changes in a family. The clinical characteristics of a child diagnosed with Peutz-Jeghers syndrome in our hospital and his parents were summarized, and related genes were detected in the child and his parents. Furthermore, the therapeutic effect of letrozole was also observed. Read More

    [Cornelia de Lange Syndrome and multiple hormonal deficiency, an unusual association. Clinical case].
    Arch Argent Pediatr 2017 06;115(3):e170-e174
    Escuela de Medicina, Universidad Industrial de Santander.
    Cornelia de Lange syndrome is a genetic disease characterized by distinctive facial features, failure to thrive, microcephaly and several malformations associated. Its main endocrinological features are anomalies of the genitalia. We present a 13-year-old boy, who suffered from complicated aspiration pneumonia and showed Cornelia de Lange syndrome phenotype, with global developmental delay, suction-swallowing abnormalities, short stature and abnormal genitalia associated. Read More

    Role of microRNAs in premature ovarian insufficiency.
    Reprod Biol Endocrinol 2017 May 12;15(1):38. Epub 2017 May 12.
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.
    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. Read More

    Bone mineral density in complete androgen insensitivity syndrome and the timing of gonadectomy.
    Clin Endocrinol (Oxf) 2017 Aug 8;87(2):136-140. Epub 2017 Jun 8.
    Institute for Women's Health, University College London Hospitals, London, UK.
    Objective: Low bone mineral density (BMD) has been reported in complete androgen insensitivity syndrome (CAIS), but the impact of timing of gonadectomy is not known. We aimed to assess the relationship between age of gonadectomy and BMD in women with CAIS.

    Design: Retrospective analysis of pre- and post-gonadectomy parameters in women with CAIS attending an adult Disorders of Sex Development (DSD) clinic in a tertiary centre. Read More

    Gonadotropin levels in urine during early postnatal period in small for gestational age preterm male infants with fetal growth restriction.
    J Perinatol 2017 Jul 27;37(7):843-847. Epub 2017 Apr 27.
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Objective: The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development.

    Study Design: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test. Read More

    Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.
    Eur J Endocrinol 2017 Jul 21;177(1):93-102. Epub 2017 Apr 21.
    Unidade de Endocrinologia do DesenvolvimentoLaboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia.
    Background: The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is often difficult. Read More

    Factors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients.
    Clin Exp Reprod Med 2017 Mar 31;44(1):22-27. Epub 2017 Mar 31.
    Medical Genetics Laboratory, Al-Zahra University Hospital, Isfahan, Iran.
    Objective: Azoospermia owing to testicular disorders is the most severe manifestation of male infertility. The main concern for patients with nonobstructive azoospermia (NOA) is the probability of successful sperm retrieval following testicular sperm extraction (TESE). Therefore, the goal of this study was to determine predictive factors correlated with sperm retrieval. Read More

    Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome.
    EBioMedicine 2017 Apr 18;18:157-170. Epub 2017 Mar 18.
    Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
    Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of metformin on PCOS-related uterine dysfunction. In addition to reducing androgen levels, improving insulin sensitivity, and correcting the reproductive cycle, metformin treatment induced morphological changes in the PCOS-like uterus. Read More

    Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
    J Clin Endocrinol Metab 2017 Apr;102(4):1102-1111
    Assistance Publique-Hôpitaux de Paris.
    Context: Isolated hypogonadotropic hypogonadism (IHH), characterized by gonadotropin deficiency and absent puberty, is very rare in women. IHH prevents pubertal ovarian stimulation, but anti-Müllerian hormone (AMH) and antral follicle count (AFC) have not been studied.

    Objectives: (1) To compare, in IHH vs controls, AMH, ovarian volume (OV), and AFC. Read More

    A modified vitrification method reduces spindle and chromosome abnormalities.
    Syst Biol Reprod Med 2017 Jun 9;63(3):199-205. Epub 2017 Mar 9.
    a Medical Center for Human Reproduction , Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China.
    Development of an effective system for oocyte-cryopreservation is of clinical relevance in reproductive medicine. However, oocyte-preservation is not as effective as embryo preservation. In this study, we used a 37°C pre-equilibrium temperature as part of a modified vitrification method for human oocyte cryopreservation. Read More

    Chronic Intake of Green Propolis Negatively Affecting the Rat Testis.
    Pharmacognosy Res 2017 Jan-Mar;9(1):27-33
    Reproductive Biology Laboratory, Department of Structural and Functional Biology, Biology Institute, State University of Campinas - UNICAMP, Campinas, Brazil.
    Background: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. Read More

    Hyperandrogenemia and high prolactin in congenital utero-vaginal aplasia patients.
    Reproduction 2017 05 28;153(5):555-563. Epub 2017 Feb 28.
    Department of Gynecology and ObstetricsLaboratory of Molecular Medicine, University Hospital Erlangen, Erlangen, Germany
    Patients with the Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) have a congenital utero-vaginal cervical aplasia, but normal or hypoplastic adnexa and develop with normal female phenotype. Some reports mostly demonstrated regular steroid hormone levels in small MRKH cohorts including single MRKH patients with hyperandrogenemia and a clinical presentationof hirsutism and acne has also been shown. Genetically a correlation of mutations with singular MRKH patients and hyperandrogenemia was noted. Read More

    17α-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.
    Endocr Pract 2017 May 22;23(5):576-582. Epub 2017 Feb 22.
    Objective: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in the cytochrome P450 17A1 (CYP17A1) gene. To better understand 17OHD, a rare disease, we described the clinical features and performed CYP17A1 gene analysis in 8 affected Chinese patients.

    Methods: Patients with complete (7/8) or partial (1/8) 17OHD were derived from 6 families. Read More

    Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism.
    Hormones (Athens) 2016 Oct;15(4):518-526
    Department of Growth and Reproduction, and International Center for Research and Research Training on Endocrine Disrupting Effects on Male Reproduction & Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
    Objective: Testicular dysgenesis syndrome (TDS) comprises testicular germ cell cancer, cryptorchidism and some cases of male infertility and hypospadias, which can be linked to impairment of intrauterine gonadal development. Among histological signs of TDS, large Leydig cell (LC) clusters (micronodules) are frequently present. This study aimed to investigate possible associations of LC micronodules with the presence of Reinke crystals and hormonal function of LCs, the latter primarily reflected by serum concentrations of luteinising hormone (LH) and testosterone, in patients with TDS. Read More

    Adolescent gynecomastia is associated with a high incidence of obesity, dysglycemia, and family background of diabetes mellitus.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):160-164
    Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.
    Background: Gynecomastia during adolescence is common though etiology is not clear. We studied the clinical and hormonal profile of adolescent patients with gynecomastia.

    Methodology: Patients who had onset of breast development between age 10 and 20 years were included in this study. Read More

    Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism.
    Clin Genet 2017 Aug 30;92(2):213-216. Epub 2017 Mar 30.
    Endocrinology, Diabetology & Metabolism Service, Lausanne University Hospital, Lausanne, Switzerland.
    Neonatal micropenis and cryptorchidism raise the suspicion of congenital hypogonadotropic hypogonadism (CHH), a rare genetic disorder caused by gonadotropin-releasing hormone deficiency. Low plasma testosterone levels and low gonadotropins during minipuberty provide a clinical diagnostic clue, yet these tests are seldomly performed in general practice. We report a male neonate with no family history of reproductive disorders who was born with micropenis and cryptorchidism. Read More

    Extreme spermatogenesis failure: andrological phenotype and intracytoplasmic sperm injection outcomes.
    Andrology 2017 03 10;5(2):219-225. Epub 2017 Feb 10.
    Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, Centre Hospitalier Régional Universitaire, Lille, France.
    Patients with very low sperm count through direct sperm examination can exhibit extreme oligozoospermia or cryptozoospermia (after centrifugation). The management of these patients is a real challenge for both clinicians and biologists. In this retrospective and comparative cohort study, we compared the andrological phenotype of patients with extreme alterations of spermatogenesis and assessed whether the origin of spermatozoa (testicular or ejaculate) had any influence on intracytoplasmic sperm injection (ICSI) outcomes. Read More

    Is acne a sign of androgen excess disorder or not?
    Eur J Obstet Gynecol Reprod Biol 2017 Apr 23;211:21-25. Epub 2017 Jan 23.
    Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
    Objective: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Read More

    Ginkgo Biloba Ameliorates Subfertility Induced by Testicular Ischemia/Reperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism.
    Oxid Med Cell Longev 2016 22;2016:6959274. Epub 2016 Dec 22.
    Dermatology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Testicular torsion, a surgical emergency, could affect the endocrine and exocrine testicular functions. This study demonstrates histopathological and physiological effects of testicular ischemia/perfusion (I/R) injury and the possible protective effects of Ginkgo biloba treatment. Fifty adult male Wistar rats, 180-200 gm, were randomly divided into sham-operated, Gingko biloba supplemented, ischemia only, I/R, and Gingko biloba treated I/R groups. Read More

    Efficacy and Safety of Continuous Subcutaneous Infusion of Recombinant Human Gonadotropins for Congenital Micropenis during Early Infancy
.
    Horm Res Paediatr 2017 12;87(2):103-110. Epub 2017 Jan 12.
    Background: Early postnatal administration of gonadotropins to infants with congenital hypogonadotropic hypogonadism (CHH) can mimic minipuberty, thereby increasing penile growth. We assessed the effects of gonadotropin infusion on stretched penile length (SPL) and hormone levels in infants with congenital micropenis.

    Methods: Single-center study including 6 males with micropenis in case of isolated CHH (n = 4), panhypopituitarism (n = 1), and partial androgen insensitivity syndrome (PAIS; n = 1). Read More

    Delayed treatment of undescended testes may promote hypogonadism and infertility.
    Endocrine 2017 Mar 9;55(3):914-924. Epub 2017 Jan 9.
    Center of Reproductive Medicine and Andrology, Department of Clinical Andrology, University of Muenster, Albert-Schweitzer-Campus 1, Building D11, D-48149, Muenster, Germany.
    Context: Undescended testes at birth may be caused by testosterone deficiency during fetal development. It is unclear whether the process of failed descent contributes to permanent endocrine impairment.

    Objectives: To evaluate the impact of age at treatment of undescended testes on endocrine and spermatogenic testicular function in middle-aged men. Read More

    The effects of IL-1A and IL-6 genes polymorphisms on gene expressions, hormonal and biochemical parameters in polycystic ovary syndrome.
    J Obstet Gynaecol 2017 Apr 26;37(3):358-362. Epub 2016 Dec 26.
    e Department of Public Health, Faculty of Medicine , Balikesir University , Balikesir , Turkey.
    Polycystic ovary syndrome (PCOS) is a multifactorial disease characterised by chronic inflammation. We aimed to investigate an association between IL-1A and IL-6 gene polymorphisms and both hormonal/biochemical parameters and levels of IL-1A and IL-6. A total of 103 women diagnosed with PCOS according to ESHRE/ASRM criteria were investigated. Read More

    Delayed Diagnosis of a 17-Hydroxylase/17,20-Lyase Deficient Patient Presenting as a 46,XY Female: A Low Normal Potassium Level Can Be an Alerting Diagnostic Sign.
    J Clin Res Pediatr Endocrinol 2017 Jun 23;9(2):163-167. Epub 2016 Dec 23.
    Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey, E-mail:
    17-hydroxylase/17,20-lyase deficiency (17-OHD), a rare autosomal recessive defect in adrenal and gonadal steroidogenesis, causes absence of secondary sexual characteristics and frequently associated with hypertension and hypokalemia. Here, we report a 46,XY case who had normal potassium levels and no hypertension. Our patient was a 2. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis.
    Eur J Endocrinol 2017 Mar 22;176(3):R159-R166. Epub 2016 Dec 22.
    Laboratory of Experimental Surgery and Surgical Research N.S. ChristeasAthens University Medical School, Athens, Greece.
    Objective: Subclinical hypothyroidism (SCH) is encountered in 10-25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. Read More

    Evaluation of ovarian reserve using anti-müllerian hormone and antral follicle count in Sjögren's syndrome: Preliminary study.
    J Obstet Gynaecol Res 2017 Feb 17;43(2):303-307. Epub 2016 Dec 17.
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
    Aim: The aim of this study was to determine ovarian reserve status using anti-müllerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjögren's syndrome (SS).

    Methods: Twenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels. Read More

    Correlation of genetic results with testicular histology, hormones and sperm retrieval in nonobstructive azoospermia patients with testis biopsy.
    Andrologia 2017 Sep 6;49(7). Epub 2016 Dec 6.
    Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University) Ministry of Education, Jinan, China.
    To investigate the frequency and types of genetic results in different testicular histology of patients with nonobstructive azoospermia (NOA), and correlated with hormones and sperm retrieval (SR), a retrospective study was conducted in 286 Chinese NOA patients who underwent testis biopsy and 100 age-matched fertile men as the control group. Chromosome karyotype analyses were performed by the peripheral blood chromosome G-band detection method. Screening of Y chromosome microdeletions of azoospermia factor (AZF) region was performed by polymerase chain reaction (PCR) amplification of 11 sequence-tagged sites (STS). Read More

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