2,973 results match your criteria Follicle-Stimulating Hormone Abnormalities


An Assay on the Possible Effect of Essential Oil Constituents on Receptors Involved in Women's Hormonal Health and Reproductive System Diseases.

J Evid Based Integr Med 2020 Jan-Dec;25:2515690X20932527

Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Aromatic herbal remedies, hydrosols, and essential oils are widely used for women's hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. Read More

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http://dx.doi.org/10.1177/2515690X20932527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309338PMC

LEYDIG CELL HYPOPLASIA: A UNIQUE PARADOX IN THE DIAGNOSIS OF 46,XY DISORDERS OF SEX DEVELOPMENT.

AACE Clin Case Rep 2020 May-Jun;6(3):e117-e122. Epub 2020 May 11.

Objective: Disorders of sex development (DSD) are defined as conditions in which chromosomal sex is inconsistent with phenotypic sex, or in which the phenotype is not classifiable as either male or female. Mutations in genes present in X, Y or autosomal chromosomes can cause abnormalities of testis determination or 46,XY DSD. Leydig cell hypoplasia (LCH), also known as Leydig cell agenesis, is a rare autosomal recessive endocrine syndrome of 46,XY DSD. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282282PMC

Single-cell DNA methylation sequencing reveals epigenetic alterations in mouse oocytes superovulated with different dosages of gonadotropins.

Clin Epigenetics 2020 Jun 1;12(1):75. Epub 2020 Jun 1.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 North HuaYuan Road, Hai Dian District, Beijing, 100191, China.

Background: Epigenetic abnormalities caused by superovulation have recently attracted increasing attention. Superovulation with exogenous hormones may prevent oocytes from establishing an appropriate epigenetic state, and this effect may extend to the methylation programming in preimplantation embryos, as de novo DNA methylation is a function of developmental stage of follicles and oocyte size. Follicle-stimulating hormone (FSH) and human menopausal gonadotropin (hMG) are common gonadotropins used for superovulation, and appropriate concentrations of these gonadotropins might be necessary. Read More

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http://dx.doi.org/10.1186/s13148-020-00866-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268365PMC

Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota.

Food Funct 2020 Jun;11(6):5192-5204

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China. and School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, PR China and Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, PR China.

Polycystic ovarian syndrome (PCOS) is a common endocrine disease across the world. Because gut microbiota play a key role in the pathogenesis of PCOS, probiotics may alleviate PCOS symptoms through the regulation of intestinal flora. The effects of 8 lactic acid bacterial strains on PCOS were investigated. Read More

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http://dx.doi.org/10.1039/c9fo02554eDOI Listing

leaves extract modulates toxicity, sperms alterations, oxidative stress, and testicular damage induced by tramadol in male rats.

Toxicol Res (Camb) 2020 Apr 24;9(2):101-106. Epub 2020 Apr 24.

Zoology Department, Faculty of Science, Tanta University, Egypt.

Tramadol is a synthetic opioid analgesic used for moderate-to-severe pain structurally related to codeine and morphine, where their analgesic mechanism is a result of opioid and non-opioid mechanisms. This study was designed to evaluate the effects of leaves extract (MLE) on tramadol-induced testicular toxicity, sperm changes, testicular damage, and oxidative stress in male rats. Forty male albino rats were divided into four groups and treated for 4 weeks (group 1, as control; group 2, MLE; group 3, tramadol; group 4, MLE + tramadol). Read More

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http://dx.doi.org/10.1093/toxres/tfaa009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233315PMC

Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson's disease.

Environ Toxicol Pharmacol 2020 May 18;78:103412. Epub 2020 May 18.

Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

Although sexual health is affected by Parkinson's disease (PD), the effect on testicular health and/or sperm quality is not well discussed. After 21 days of rotenone lesioning, we observed dopaminergic neuronal degeneration in the substantia nigra and hypothalamus. There were minimal SPACA-1-expressing epididymal spermatozoa with morphological abnormalities, scanty luminal spermatozoa and reduced testicular spermatids and post-meiotic germ cells indicating hypospermatogenesis. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103412DOI Listing

Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.

Front Endocrinol (Lausanne) 2020 5;11:256. Epub 2020 May 5.

Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Whether girls with central precocious puberty (CPP) should undergo routine brain magnetic resonance imaging (MRI) to identify potential intracranial pathologies is controversial. To evaluate the brain MRI results of girls with CPP and identify the clinical and endocrine predictors of brain abnormalities. This retrospective study obtained data from pediatric endocrine clinics at Chang Gung Children's Hospital. Read More

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http://dx.doi.org/10.3389/fendo.2020.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214687PMC

Distinguishing between hidden testes and anorchia: the role of endocrine evaluation in infancy and childhood.

Eur J Endocrinol 2020 Jul;183(1):107-117

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Objective: Non-palpable testes remain a diagnostic challenge, often involving exploratory laparoscopy. We evaluated the diagnostic value of a wide range of reproductive hormones in order to distinguish between bilateral cryptorchidism and bilateral anorchia.

Design: In this retrospective study, we identified and included 36 boys with non-palpable testes (20 with cryptorchidism, 3 with congenital hypogonadotropic hypogonadism (CHH), and 13 with anorchia) at first examination during childhood. Read More

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http://dx.doi.org/10.1530/EJE-20-0041DOI Listing

Pituitary hyperplasia with Sertoli cell-only and 47,XYY syndromes: an uncommon triad.

BMJ Case Rep 2020 May 14;13(5). Epub 2020 May 14.

Arrowe Park Hospital, Wirral, UK.

We report the case history of a 32-year-old man with no phenotypical abnormalities who presented with infertility. Semen analysis revealed azoospermia and testicular biopsy confirmed Sertoli cell-only (SCO) syndrome. Karyotyping revealed 47,XYY and pituitary hyperplasia was found on MRI pituitary. Read More

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http://dx.doi.org/10.1136/bcr-2019-233100DOI Listing

Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors.

J Clin Med 2020 May 9;9(5). Epub 2020 May 9.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Heliodor Święcicki Hospital, 60-355 Poznań, Poland.

In up to 50% of cases, infertility issues stem solely from the male. According to some data, the quality of human semen has deteriorated by 50%-60% over the last 40 years. A high-fat diet and obesity, resulting from an unhealthy lifestyle, affects the structure of spermatozoa, but also the development of offspring and their health in later stages of life. Read More

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http://dx.doi.org/10.3390/jcm9051400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291266PMC

Multisystemic Impairments in 93 Chinese Patients With Myotonic Dystrophy Type 1.

Front Neurol 2020 21;11:277. Epub 2020 Apr 21.

Department of Neurology of the First Medical Center, Chinese PLA General Hospital, Beijing, China.

Myotonic dystrophy type 1 (DM1) is an autosomal dominant neuromuscular disease characterized by muscle weakness and multisystemic impairments, which significantly impact the quality of life. There is currently an increasing consensus on the necessity of a multidisciplinary assessment in patients with DM1, to improve the management of the disease. To analyze the prevalence and pairwise relationships between various organs involved, we performed a retrospective study by reviewing demographic and clinical information of DM1 patients including age, disease duration, clinical history, muscular impairment rating scale score (MIRS), results of blood biochemistry, electrocardiogram, echocardiography, and ophthalmologic examination. Read More

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http://dx.doi.org/10.3389/fneur.2020.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186325PMC

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.

J Hum Genet 2020 Aug 27;65(8):683-691. Epub 2020 Apr 27.

Department of Urology, St. Marianna University School of Medicine, Kanagawa, 216-8511, Japan.

Semen quality is affected by environmental factors, endocrine function abnormalities, and genetic factors. A GWAS recently identified ERBB4 at 2q34 as a genetic locus associated with sperm motility. However, GWASs for human semen volume and sperm concentration have not been conducted. Read More

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http://dx.doi.org/10.1038/s10038-020-0757-3DOI Listing
August 2020
2.462 Impact Factor

Serum vitamin D content is associated with semen parameters and serum testosterone levels in men.

Asian J Androl 2020 Apr 28. Epub 2020 Apr 28.

Androscience, Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory, Sao Paulo 04534-011, Brazil.

The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels. This is a cross-sectional study conducted at Androscience, Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo, Brazil, with 508 male patients, aged 18-60 years, from 2007 to 2017. Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria. Read More

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http://dx.doi.org/10.4103/aja.aja_9_20DOI Listing
April 2020
2.530 Impact Factor

Peptide hormone analysis in diagnosis and treatment of Differences of Sex Development: joint position paper of EU COST Action 'DSDnet' and European Reference Network on Rare Endocrine Conditions.

Eur J Endocrinol 2020 Jun;182(6):P1-P15

Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Differences of Sex Development (DSD) comprise a variety of congenital conditions characterized by atypical chromosomal, gonadal, or anatomical sex. Diagnosis and monitoring of treatment of patients suspected of DSD conditions include clinical examination, measurement of peptide and steroid hormones, and genetic analysis. This position paper on peptide hormone analyses in the diagnosis and control of patients with DSD was jointly prepared by specialists in the field of DSD and/or peptide hormone analysis from the European Cooperation in Science and Technology (COST) Action DSDnet (BM1303) and the European Reference Network on rare Endocrine Conditions (Endo-ERN). Read More

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http://dx.doi.org/10.1530/EJE-19-0831DOI Listing

Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors.

J Neurosurg 2020 Feb 7:1-9. Epub 2020 Feb 7.

Departments of1Neurologic Surgery and.

Objective: Intracranial germ cell tumors (iGCTs) often arise at the neurohypophysis, their second most common origination, following the pineal region. Neurohypophyseal iGCTs present with stereotypical symptoms, including pituitary dysfunction and visual field deficit, due to their suprasellar location. The goal of this study was to present a large, longitudinal single-institution experience with neurohypophyseal iGCTs to better understand their natural history and identify opportunities for further improvement in treatment outcomes. Read More

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http://dx.doi.org/10.3171/2019.10.JNS191136DOI Listing
February 2020

Hysterosalpingographic Findings of Infertile Patients Presenting to Our Reproductive Endocrinology Department: Analysis of 1,996 Cases.

Curr Med Imaging Rev 2019;15(8):777-784

Department of Radiology, Konya Education and Research Hospital, Konya, Turkey.

Background: To evaluate the hysterosalpingography (HSG) findings of women with infertility in a tertiary center located in central Turkey.

Methods: A total of 1,996 patients undergoing the HSG procedure for the investigation of infertility from April 2012 to 2017 were retrospectively evaluated using the archives of the reproductive endocrinology and radiology departments. Demographic and clinical characteristics of patients with normal HSG findings (n = 1,549) and patients with abnormal HSG findings (n = 447) were compared, and the distribution of pathologies on the HSG examinations was evaluated as well. Read More

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http://dx.doi.org/10.2174/1573405614666180913114802DOI Listing
January 2019

Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome.

J Assist Reprod Genet 2020 Feb 4;37(2):347-357. Epub 2020 Jan 4.

Follicle Biology Laboratory, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussel, Belgium.

Purpose: Standard oocyte in vitro maturation (IVM) usually results in lower pregnancy rates than in vitro fertilization (IVF). IVM preceded by a prematuration step improves the acquisition of oocyte developmental competence and can enhance embryo quality (EQ). This study evaluated the effectiveness of a biphasic culture system incorporating prematuration and IVM steps (CAPA-IVM) versus standard IVM in women with polycystic ovarian morphology (PCOM). Read More

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http://dx.doi.org/10.1007/s10815-019-01677-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056678PMC
February 2020

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females.

Int J Dermatol 2020 Apr 3;59(4):428-433. Epub 2020 Jan 3.

Department of Dermatology, Dr Ram Manohar Lohia Hospital & Post Graduate Institute of Medical Education and Research, New Delhi, India.

Background: Adult acne has been classified into two major subtypes: "persistent acne" and "late onset acne". A surrogate marker of hyperandrogenism (HA) in adult female acne is the presence of clinical signs of HA and biochemical hyperandrogenemia. We compared the clinical and hormonal profiles of the two acne subtypes and evaluated the likely source of androgen excess - ovarian or adrenal. Read More

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http://dx.doi.org/10.1111/ijd.14748DOI Listing
April 2020
1.227 Impact Factor

Child with '46, XX' disorder of sex development: clues to diagnose aromatase deficiency.

BMJ Case Rep 2019 Dec 3;12(12). Epub 2019 Dec 3.

Endocrinology & Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India.

A diagnosis of congenital adrenal hyperplasia (CAH) in a '46, XX' newborn with ambiguous genitalia is like a 'knee jerk reaction' of the paediatrician because of its higher frequency and life-threatening consequences if remain undiagnosed and hence untreated. Aromatase deficiency (AD), a rare cause of '46, XX' disorder of sex development, mimics virilising CAH in many aspects; thus, the disease is often overlooked. Diagnosis of AD in women is much easier around puberty due to the presence of primary amenorrhoea, undeveloped breasts, androgen excess and tall stature with eunuchoid proportions. Read More

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http://dx.doi.org/10.1136/bcr-2019-232575DOI Listing
December 2019

Kallmann Syndrome with Syndactyly.

J Coll Physicians Surg Pak 2019 Dec;29(12):S101-S102

Department of Gynecology and Obstetrics, Military and Training Hospital Mohammed V, Rabat, Morocco.

Kallmann syndrome is a rare genetic disorder marked by hypogonadotropic hypogonadism (HH) and anosmia, affecting 1 in 50,000 females. It is due to a defect of gonadotropin-releasing hormone (GnRH)-secreting neurons migration from the nasal olfactory epithelium to the basal hypothalamus. Non-reproductive, non-olfactory symptoms can also be present, depending on the genetic form of disease. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.12.S101DOI Listing
December 2019

BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.

J Clin Endocrinol Metab 2020 Apr;105(4)

Inserm U1185, Faculté de Médecine Paris Sud, France.

Context: Primary ovarian insufficiency (POI) is a frequently occurring disorder affecting approximately 1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels of follicle-stimulating hormone, leads to infertility. Although various etiological factors have been described, including chromosomal abnormalities and gene mutations, most cases remain idiopathic. Read More

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http://dx.doi.org/10.1210/clinem/dgz226DOI Listing

Karyotypic abnormalities and molecular analysis of Y chromosome microdeletion in Iranian Azeri Turkish population infertile men.

Syst Biol Reprod Med 2020 Apr 5;66(2):140-146. Epub 2019 Nov 5.

Department of Clinical Biochemistry and Genetics, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.

Infertility is one of the major health-threatening problems in communities which may lead to psychological problems among couples. Y chromosome abnormalities and microdeletions have recently been considered as one of the male infertility factors. The aim of this study was to evaluate different chromosomal disorders and azoospermia factor b (AZFb), AZFc and AZFd microdeletions in idiopathic non-obstructive oligo or azoospermia infertile men. Read More

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http://dx.doi.org/10.1080/19396368.2019.1682083DOI Listing
April 2020
1.700 Impact Factor

Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism despite Orchiopexy within the First Year of Life.

J Urol 2020 04 23;203(4):832-840. Epub 2019 Oct 23.

Department of Pediatric Surgery, Surgical Clinic C, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Purpose: One of the concerns surrounding cryptorchidism is the risk of impaired fertility. Current guidelines recommend orchiopexy at age 6 to 12 months to optimize fertility outcome. We evaluated the fertility potential of boys with nonsyndromic cryptorchidism who underwent orchiopexy within the recommended age range to clarify the need for eventual supplemental treatment modalities. Read More

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http://dx.doi.org/10.1097/JU.0000000000000615DOI Listing

Placental pathology in live births conceived with in vitro fertilization after fresh and frozen embryo transfer.

Am J Obstet Gynecol 2020 04 4;222(4):360.e1-360.e16. Epub 2019 Oct 4.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: The availability and use of frozen embryos after ovarian hyperstimulation for assisted reproduction has increased with improvement in vitrification techniques and the rise of preimplantation genetic testing. However, there are conflicting data regarding whether obstetric outcomes differ between fresh and frozen embryo transfer cycles.

Objective: To compare placental pathology from live births arising from fresh and frozen embryo transfer cycles. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.09.047DOI Listing

Infertility case presentation in Zinner syndrome: Can a long-lasting seminal tract obstruction cause secretory testicular injury?

Andrologia 2019 Dec 7;51(11):e13436. Epub 2019 Oct 7.

Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Zinner syndrome (ZS) could represent an uncommon cause of male infertility, as result of the ejaculatory duct block, which typically leads to low seminal volume and azoospermia. A 27-year-old Caucasian man reported persistent events of scrotal-perineal pain and dysuria during the past 6 months. The andrological examination showed testicular volume of 10 ml bilaterally. Read More

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http://dx.doi.org/10.1111/and.13436DOI Listing
December 2019
5 Reads

Klinefelter's syndrome with systemic lupus erythematosus and atrial fibrillation.

Lupus 2019 Oct 24;28(12):1477-1479. Epub 2019 Sep 24.

Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, PR China.

We describe a 65-year-old man who presented with arthralgia, reduced body hair and gynecomastia. He showed severe pancytopaenia. Laboratory examination revealed high follicle-stimulating hormone, low testosterone and oestradiol, elevated antinuclear antibodies, anti-dsDNA and ESR levels, as well as low complement levels. Read More

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http://dx.doi.org/10.1177/0961203319877256DOI Listing
October 2019
2 Reads

Genetic and sex hormone analysis of infertile men.

J Int Med Res 2019 Sep 19:300060519875893. Epub 2019 Sep 19.

Center for Reproductive Medicine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, China.

Objective: Genetic defects and endocrine-related factors are the leading causes of male infertility. This study was performed to analyze the genetic characteristics and sex hormone levels in different types of male infertility.

Methods: A total of 423 men with infertility underwent genetic and sex hormone analysis at The Sixth Affiliated Hospital of Guangzhou Medical University. Read More

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http://dx.doi.org/10.1177/0300060519875893DOI Listing
September 2019
1 Read

Severe arterial hypertension and hyperandrogenism in a boy: a rare case of catecholamine- and β-HCG-secreting pheochromocytoma.

J Pediatr Endocrinol Metab 2019 Oct;32(10):1193-1197

Regina Margherita Children's Hospital, Pediatric Endocrinology, AOU Citta della Salute e della Scienza, University of Turin, Turin, Italy.

Background Pheochromocytomas (PCCs) and paragangliomas (PGLs) are known to physicians as the "great mimickers" because of their variable presentation, especially in the pediatric population. Rarely, they co-secrete other hormones. Case presentation An 11-year-old boy presented with severe hypertension (HTN) with cardiac target organ damage. Read More

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http://dx.doi.org/10.1515/jpem-2019-0216DOI Listing
October 2019
3 Reads

Reproductive toxic effects and possible mechanisms of zonisamide in male rats.

Hum Exp Toxicol 2019 Dec 2;38(12):1384-1396. Epub 2019 Sep 2.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. Therefore, we aimed to assess the effects of ZNS on male reproductive system by oral administration to rats in 25, 50, and 100 mg/kg doses for 28 days. Read More

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http://dx.doi.org/10.1177/0960327119871094DOI Listing
December 2019

Isolated follicle-stimulating hormone (FSH) deficiency in two infertile men without FSH β gene mutation: Case report and literature review.

Ann Endocrinol (Paris) 2019 Sep 8;80(4):234-239. Epub 2019 Jul 8.

Department of Endocrinology and Reproductive Medicine, University Hospital of Nice, 151, route de Saint-Antoine, 06200 Nice, France.

Objective: Congenital FSH deficiency is an exceptional cause of male infertility most often attributed to FSH β gene mutations. The few published cases report azoospermia, severe testicular hypotrophy and normal testosterone levels associated with normal virilization. We report the exploration of two young men aged 26 and 27 years with severe sperm abnormalities, moderate testicular hypotrophy and isolated FSH deficiency. Read More

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http://dx.doi.org/10.1016/j.ando.2019.06.002DOI Listing
September 2019
2 Reads

Diagnostic accuracy of human chorionic gonadotropins (HCG) stimulation test in XY-disorders of sex development (XY-DSD) presented in Armed Forces Institute of Pathology.

J Pak Med Assoc 2019 Aug;69(8):1090-1093

Armed Forced Institute of Pathology, Rawalpindi.

Objective: To determine diagnostic accuracy of human chorionic gonadotropins stimulation test in differentiating androgen insensitivity syndrome and 5-alpha reductase deficiency, keeping testosterone to dihydrotestosterone ratio as the gold standard.

Methods: The cross-sectional study was conducted at the Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to December, 2016, and comprised patients aged 01 day to 20 years having XY chromosomes on karyotyping and with a spectrum of phenotypes. Blood samples were collected from each subject for basal serum testosterone, serum luteinizing hormone and serum follicular stimulating hormone level. Read More

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August 2019
1 Read

Male sickle cell patients, compensated transpubertal hypogonadism and normal final growth.

Clin Endocrinol (Oxf) 2019 11 4;91(5):676-682. Epub 2019 Sep 4.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Objective: Investigate the gonadal hormonal function in sickle cell individuals.

Context: Sickle cell disease (SCD) is associated with delayed physical and sexual development, and it has been related to both primary testicular failure and hypothalamo-pituitary-gonadal axis abnormalities.

Design: The study of the pituitary gonadotrophin reserve was done evaluating the hormonal levels before and after stimulation by gonadoliberin. Read More

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http://dx.doi.org/10.1111/cen.14075DOI Listing
November 2019
3 Reads

Effects of hypogonadism on brain development during adolescence in girls with Turner syndrome.

Hum Brain Mapp 2019 12 7;40(17):4901-4911. Epub 2019 Aug 7.

State Key Laboratory of Cognitive Neuroscience and Learning &IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Gonadal steroids play an important role in brain development, particularly during puberty. Girls with Turner syndrome (TS), a genetic disorder characterized by the absence of all or part of the second X chromosome, mostly present a loss of ovarian function and estrogen deficiency, as well as neuroanatomical abnormalities. However, few studies have attempted to isolate the indirect effects of hormones from the direct genetic effects of X chromosome insufficiency. Read More

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http://dx.doi.org/10.1002/hbm.24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865434PMC
December 2019
11 Reads

Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Patients: A Randomized, Placebo-Controlled Clinical Trial.

Adv Pharmacol Sci 2019 1;2019:9680390. Epub 2019 Jul 1.

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Damascus, Syria.

Objective: This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women.

Study Design: This is a randomized, placebo-controlled clinical trial.

Setting: This study was performed in Damascus University of Obstetrics and Gynecology Hospital and Orient Hospital, in Damascus, Syria. Read More

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http://dx.doi.org/10.1155/2019/9680390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636596PMC
July 2019
5 Reads

Polycystic ovary syndrome dependency on mtDNA mutation; copy Number and its association with insulin resistance.

BMC Res Notes 2019 Jul 24;12(1):455. Epub 2019 Jul 24.

Dept. of Basic Science, College of Dentistry, Mustansiriyah University, POX 10422, Baghdad, Iraq.

Objective: Study analyzes mutation in mtDNA (Mitochondrial DNA) among diabetic women with PCOS in non-diabetic diabetic women and compared with the healthy control. Women with known case of hyperandrogenism, ovulatory dysfunction and/or polycystic ovaries were selected and anthropometric and demographic variables were collected during their clinical visit. Biochemical estimation of glucose, FSH, LH, estradiol (E2), and insulin levels were analyzed. Read More

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http://dx.doi.org/10.1186/s13104-019-4453-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657173PMC
July 2019
2 Reads

Evaluation of sexual function and micro- testicular sperm extraction in men with mosaic Turner syndrome.

Natl Med J India 2018 Sep-Oct;31(5):274-278

Department of Medical Genetics, Necmettin Erbakan University, Meram, 42060 Konya, Turkey.

Background: Men with mosaic Turner syndrome (TS) having karyotype 45,X/46,XY are infrequently seen. Their sexual function and fertility potential are not well documented. We describe the sexual function and outcomes of sperm extraction in 5 such men who were evaluated between 2008 and 2017. Read More

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http://dx.doi.org/10.4103/0970-258X.261196DOI Listing
October 2019
3 Reads

Amenorrhea: A Systematic Approach to Diagnosis and Management.

Am Fam Physician 2019 07;100(1):39-48

Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.

Menstrual patterns can be an indicator of overall health and self-perception of well-being. Primary amenorrhea, defined as the lifelong absence of menses, requires evaluation if menarche has not occurred by 15 years of age or three years post-thelarche. Secondary amenorrhea is characterized by cessation of previously regular menses for three months or previously irregular menses for six months and warrants evaluation. Read More

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July 2019
16 Reads

Flaxseed oil modulates semen production and its quality profiles, freezability, testicular biometrics and endocrinological profiles in mithun.

Theriogenology 2019 Sep 19;136:47-59. Epub 2019 Jun 19.

Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Uttar Pradesh, India.

Mithun (Bos frontalis) is a unique domestic free range bovine species of North Eastern Hilly (NEH) regions of India. Effect of feed supplementation of Flaxseed oil (FSO) on semen production and its quality profiles, freezability, oxidative stress, apoptotic sperm percentage and subsequently on endocrinological profiles & scrotal and testicular biometrics in different seasons was studied in mithun. The experimental animals were divided into two groups, Gr I: Control (n = 3) and Gr II: Treatment (n = 3; Flaxseed oil @ 150 mL/day). Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.06.029DOI Listing
September 2019
6 Reads

Testosterone levels after treatment with urofollitropin in infertile patients with idiopathic mild reduction of testicular volume.

Endocrine 2019 11 25;66(2):381-385. Epub 2019 Jun 25.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Introduction: A reduction of testicular volume (TV) represents an important clinical sign, which may hide sperm abnormalities and predispose to hypogonadism.

Aim: The primary purpose of this study was to evaluate the serum levels of total testosterone after treatment with urofollitropin in selected patients with male infertility and idiopathic mild reduction of testicular volume.

Methods: In this 1-year-long prospective design, patients with abnormal sperm parameters, mild reduction in TV (8-12 mL) and normal gonadotropin, and total testosterone (TT) serum levels were recruited in this study. Read More

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http://dx.doi.org/10.1007/s12020-019-01983-0DOI Listing
November 2019
7 Reads
3.527 Impact Factor

Successful pregnancy outcome after septum resection and use of amnion graft in patient with high transverse vaginal septum.

BMJ Case Rep 2019 Jun 16;12(6). Epub 2019 Jun 16.

Obstetrics and Gynaecology, Services Institute of Medical Sciences, Lahore, Punjab, Pakistan.

A 20-year-old woman recently married presented to the outpatient department of the hospital, with primary amenorrhea and difficulty in having coitus. Her height was 155 cm, breast development was normal for age, and other secondary sexual characters seemed normal. On local examination, external genitalia was normal looking, and there was no vaginal discharge. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22876
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http://dx.doi.org/10.1136/bcr-2018-228769DOI Listing
June 2019
8 Reads

Klinefelter Syndrome: Clinical Spectrum Based on 44 Consecutive Cases from a South Indian Tertiary Care Center.

Indian J Endocrinol Metab 2019 Mar-Apr;23(2):263-266

Department of Cytogenetics, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Background: Klinefelter syndrome (KFS) is the commonest chromosomal abnormality, yet remains largely underdiagnosed due to its varied clinical presentation. This study was done to understand the clinical spectrum in our population.

Aim: We intended to study the clinical characteristics of children and adults with KFS in our population. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_582_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540891PMC
June 2019
10 Reads

Sertoli Cell Function in Young Males with Metabolic Syndrome.

Indian J Endocrinol Metab 2019 Mar-Apr;23(2):251-256

Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India.

Context: The last few decades have witnessed an alarming increase in the prevalence of the metabolic syndrome (MetS) worldwide including India. Apart from the known risks of MetS in terms of cardiovascular risk and mortality, there is increasing evidence that it also leads to alteration in testicular function and fertility.

Aims: To assess the presence of hypogonadism and Sertoli cell dysfunction in young adult males with MetS and correlate these parameters with different components of the MetS. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_574_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540901PMC
June 2019
14 Reads

Protective properties of glycogen synthase kinase-3 inhibition against doxorubicin-induced oxidative damage to mouse ovarian reserve.

Biomed Pharmacother 2019 Aug 21;116:108963. Epub 2019 May 21.

Institute of Reproductive Health/Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Chemotherapy induces ovarian failure in female children and young female cancer survivors. It has been shown that doxorubicin (DOX), an antitumor drug of the anthracycline group, causes gonadotoxicity via the stimulation of oxidative stress. The inhibition of glycogen synthase kinase-3 (GSK-3) was reported to be able to regulate oxidative stress. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108963DOI Listing
August 2019
2 Reads

[Subacute myopathy in a patient with mild Cushing disease manifested by accompanying Kleinfelter syndrome].

Rinsho Shinkeigaku 2019 May 26;59(5):253-257. Epub 2019 Apr 26.

Department of Neurology, Shiga University of Medical Science.

A 69-year-old man was admitted because of subacute development of lower limb weakness from one month ago. He showed central obesity, gynecomastia, dorsal fat pad ("buffalo hump"), and proximal muscle weakness in the lower extremities (manual muscle test 4). Needle EMG, muscle MRI and labolatry screening including CPK were negative for neuromuscular diseases, except for the hypogenitalism accidentally detected in MRI. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001215DOI Listing
May 2019
15 Reads

Endogenous sex hormones and risk of venous thromboembolism in young women.

J Thromb Haemost 2019 08 4;17(8):1297-1304. Epub 2019 Jun 4.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Background: The risk of venous thromboembolism (VTE) in young women can predominantly be attributed to exogenous hormone use. The influence of (abnormalities in) endogenous sex hormones, as in polycystic ovary syndrome (PCOS) or primary ovarian insufficiency (POI), on VTE risk is uncertain.

Objectives: Th assess the association between endogenous sex hormone levels and VTE risk. Read More

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http://dx.doi.org/10.1111/jth.14474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852478PMC
August 2019
19 Reads

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).

Life Sci 2019 Jul 25;228:167-175. Epub 2019 Apr 25.

Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, PR China; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. Electronic address:

Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193030
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http://dx.doi.org/10.1016/j.lfs.2019.04.046DOI Listing
July 2019
13 Reads

Mancozeb impaired male fertility in rabbits with trials of glutathione detoxification.

Regul Toxicol Pharmacol 2019 Jul 20;105:86-98. Epub 2019 Apr 20.

Animal Health Research Institute, Sohage, Egypt.

The study aims to evaluate the potential reproductive toxicity induced by mancozeb fungicide in male rabbits and to examine the ameliorative effect of glutathione (GSH), a non-enzymatic antioxidant, against mancozeb reproductive toxicity. Mancozeb is a member of the dithiocarbamates group currently in use in the management of fungal diseases of plants. To achieve these aims, mature male White New-Zealand rabbits of 4-5 months old were randomly assigned to four groups of 9 animals each: control, mancozeb only, mancozeb and GSH, and GSH only. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02732300193011
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http://dx.doi.org/10.1016/j.yrtph.2019.04.012DOI Listing
July 2019
7 Reads

Effect of metformin on clinical and biochemical hyperandrogenism in adolescent girls with type 1 diabetes.

J Pediatr Endocrinol Metab 2019 May;32(5):461-470

Department of Pediatric Endocrinology, DEMPU, Cairo University, Cairo, Egypt.

Background Hyperandrogenism with or without polycystic ovarian syndrome is seen in adolescents with type 1 diabetes (T1D), especially those with suboptimal control. Objective To assess the effect of metformin on hyperandrogenism and ovarian function in adolescents with T1D. Methods This prospective study included 28 T1D females showing signs of hyperandrogenism. Read More

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http://dx.doi.org/10.1515/jpem-2018-0430DOI Listing
May 2019
4 Reads