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    2770 results match your criteria Follicle-Stimulating Hormone Abnormalities

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    [Cornelia de Lange Syndrome and multiple hormonal deficiency, an unusual association. Clinical case].
    Arch Argent Pediatr 2017 Jun;115(3):e170-e174
    Escuela de Medicina, Universidad Industrial de Santander.
    Cornelia de Lange syndrome is a genetic disease characterized by distinctive facial features, failure to thrive, microcephaly and several malformations associated. Its main endocrinological features are anomalies of the genitalia. We present a 13-year-old boy, who suffered from complicated aspiration pneumonia and showed Cornelia de Lange syndrome phenotype, with global developmental delay, suction-swallowing abnormalities, short stature and abnormal genitalia associated. Read More

    Role of microRNAs in premature ovarian insufficiency.
    Reprod Biol Endocrinol 2017 May 12;15(1):38. Epub 2017 May 12.
    The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200030, China.
    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. Read More

    Gonadotropin levels in urine during early postnatal period in small for gestational age preterm male infants with fetal growth restriction.
    J Perinatol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Objective: The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic-pituitary-gonadal axis during the first few months of life that is important for genital development.

    Study Design: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann-Whitney test. Read More

    Factors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients.
    Clin Exp Reprod Med 2017 Mar 31;44(1):22-27. Epub 2017 Mar 31.
    Medical Genetics Laboratory, Al-Zahra University Hospital, Isfahan, Iran.
    Objective: Azoospermia owing to testicular disorders is the most severe manifestation of male infertility. The main concern for patients with nonobstructive azoospermia (NOA) is the probability of successful sperm retrieval following testicular sperm extraction (TESE). Therefore, the goal of this study was to determine predictive factors correlated with sperm retrieval. Read More

    Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH.
    J Clin Endocrinol Metab 2017 Apr;102(4):1102-1111
    Assistance Publique-Hôpitaux de Paris.
    Context: Isolated hypogonadotropic hypogonadism (IHH), characterized by gonadotropin deficiency and absent puberty, is very rare in women. IHH prevents pubertal ovarian stimulation, but anti-Müllerian hormone (AMH) and antral follicle count (AFC) have not been studied.

    Objectives: (1) To compare, in IHH vs controls, AMH, ovarian volume (OV), and AFC. Read More

    A modified vitrification method reduces spindle and chromosome abnormalities.
    Syst Biol Reprod Med 2017 Jun 9;63(3):199-205. Epub 2017 Mar 9.
    a Medical Center for Human Reproduction , Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China.
    Development of an effective system for oocyte-cryopreservation is of clinical relevance in reproductive medicine. However, oocyte-preservation is not as effective as embryo preservation. In this study, we used a 37°C pre-equilibrium temperature as part of a modified vitrification method for human oocyte cryopreservation. Read More

    Chronic Intake of Green Propolis Negatively Affecting the Rat Testis.
    Pharmacognosy Res 2017 Jan-Mar;9(1):27-33
    Reproductive Biology Laboratory, Department of Structural and Functional Biology, Biology Institute, State University of Campinas - UNICAMP, Campinas, Brazil.
    Background: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. Read More

    Adolescent gynecomastia is associated with a high incidence of obesity, dysglycemia, and family background of diabetes mellitus.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):160-164
    Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.
    Background: Gynecomastia during adolescence is common though etiology is not clear. We studied the clinical and hormonal profile of adolescent patients with gynecomastia.

    Methodology: Patients who had onset of breast development between age 10 and 20 years were included in this study. Read More

    Ginkgo Biloba Ameliorates Subfertility Induced by Testicular Ischemia/Reperfusion Injury in Adult Wistar Rats: A Possible New Mitochondrial Mechanism.
    Oxid Med Cell Longev 2016 22;2016:6959274. Epub 2016 Dec 22.
    Dermatology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Testicular torsion, a surgical emergency, could affect the endocrine and exocrine testicular functions. This study demonstrates histopathological and physiological effects of testicular ischemia/perfusion (I/R) injury and the possible protective effects of Ginkgo biloba treatment. Fifty adult male Wistar rats, 180-200 gm, were randomly divided into sham-operated, Gingko biloba supplemented, ischemia only, I/R, and Gingko biloba treated I/R groups. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: The impact of subclinical hypothyroidism on anthropometric characteristics, lipid, glucose and hormonal profile of PCOS patients: a systematic review and meta-analysis.
    Eur J Endocrinol 2017 Mar 22;176(3):R159-R166. Epub 2016 Dec 22.
    Laboratory of Experimental Surgery and Surgical Research N.S. ChristeasAthens University Medical School, Athens, Greece.
    Objective: Subclinical hypothyroidism (SCH) is encountered in 10-25% of women with PCOS. To date, it remains unclear whether this coexistence influences the severity of metabolic and hormonal profile of these patients. The purpose of our systematic review is to investigate this potential relation. Read More

    Evaluation of ovarian reserve using anti-müllerian hormone and antral follicle count in Sjögren's syndrome: Preliminary study.
    J Obstet Gynaecol Res 2017 Feb 17;43(2):303-307. Epub 2016 Dec 17.
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey.
    Aim: The aim of this study was to determine ovarian reserve status using anti-müllerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjögren's syndrome (SS).

    Methods: Twenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels. Read More

    Correlation of genetic results with testicular histology, hormones and sperm retrieval in nonobstructive azoospermia patients with testis biopsy.
    Andrologia 2016 Dec 6. Epub 2016 Dec 6.
    Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory of Reproductive Endocrinology (Shandong University) Ministry of Education, Jinan, China.
    To investigate the frequency and types of genetic results in different testicular histology of patients with nonobstructive azoospermia (NOA), and correlated with hormones and sperm retrieval (SR), a retrospective study was conducted in 286 Chinese NOA patients who underwent testis biopsy and 100 age-matched fertile men as the control group. Chromosome karyotype analyses were performed by the peripheral blood chromosome G-band detection method. Screening of Y chromosome microdeletions of azoospermia factor (AZF) region was performed by polymerase chain reaction (PCR) amplification of 11 sequence-tagged sites (STS). Read More

    Feature of amenorrhea in postoperative tamoxifen users with breast cancer.
    J Gynecol Oncol 2017 Mar 27;28(2):e10. Epub 2016 Oct 27.
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
    Objective: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In amenorrheic patients without breast cancer, clinicians usually measure the sex hormone levels that are known to be associated with ovarian or menstrual function. Read More

    Alterations in nasal mucociliary activity in polycystic ovary syndrome.
    Eur J Obstet Gynecol Reprod Biol 2016 Dec 26;207:169-172. Epub 2016 Oct 26.
    Dumlupinar University Medical Faculty, Evliya Celebi Training and Research Hospital, Department of Obstetrics and Gynecology, Okmeydani Street Evliya Celebi Avenue 43000, Kutahya, Turkey. Electronic address:
    Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. It can affect various organ systems, and respiratory mucosa has been reported as being hormone responsive.

    Study Design: A case-control study consisting of 50 women with PCOS and 30 control subjects matched for age and body mass index was conducted, in order to investigate nasal mucociliary clearance time (NMCT) in patients with PCOS. Read More

    Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring.
    Toxicol Sci 2017 Feb 1;155(2):409-419. Epub 2016 Nov 1.
    State Key Lab of Reproductive Medicine, Nanjing Medical University;
    Perfluorobutanesulfonate (PFBS) is widely used in many industrial products. We evaluated the influence of prenatal PFBS exposure on perinatal growth and development, pubertal onset, and reproductive and thyroid endocrine system in female mice. Here, we show that when PFBS (200 and 500 mg/kg/day) was orally administered to pregnant mice (PFBS-dams) on days 1-20 of gestation; their female offspring (PFBS-offspring) exhibited decreased perinatal body weight and delayed eye opening compared with control offspring. Read More

    Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats.
    Recent Pat Anticancer Drug Discov 2017 ;12(1):73-80
    Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
    Background: High doses of Cisplatin (CP) can disrupt the normal functioning of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia.

    Objective: In this study, the defensive effect of Melissa of cinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. Read More

    Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction.
    Asian J Androl 2017 Jan-Feb;19(1):39-42
    Center of Reproductive Medicine and the Department of Molecular and Cellular Biology, Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
    In couples with infertility, abnormal strict morphology of 0% normal forms (NF) is a criterion to proceed rapidly to in vitro fertilization (IVF). Since no data currently exist, we investigated the outcomes for men with 0% NF to determine reproductive success without the use of assisted reproductive technologies (ART). A cohort of 24 men with 0% NF were identified (2010-2013) with 27 randomly selected men with ≥4% NF as controls. Read More

    Clinical Applications of Gonadotropins in the Male.
    Prog Mol Biol Transl Sci 2016 13;143:121-174. Epub 2016 Sep 13.
    Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
    The pituitary gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) play a pivotal role in reproduction. The synthesis and secretion of gonadotropins are regulated by complex interactions among several endocrine, paracrine, and autocrine factors of diverse chemical structure. In men, LH regulates the synthesis of androgens by the Leydig cells, whereas FSH promotes Sertoli cell function and thereby influences spermatogenesis. Read More

    A Case of MECP2 Duplication Syndrome with Gonadotropin-Dependent Precocious Puberty.
    Horm Res Paediatr 2016 Sep 21. Epub 2016 Sep 21.
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
    Background: MECP2 duplication syndrome, which is caused by duplication of part of the Xq28 region containing the MECP2 gene, causes intellectual disability and mild dysmorphic features in males. To date, precocious puberty has not been reported as a clinical feature of MECP2 duplication syndrome.

    Methods: A 6-year-old male with severe intellectual disability was referred because of growth acceleration and precocious puberty. Read More

    Cytogenetic Investigation in a Group of Ten Infertile Men with Non-Obstructive Azoospermia: First Algerian 46, XX Syndrome.
    Iran J Public Health 2016 Jun;45(6):739-47
    Human Genome Center, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco; Department of Medical Genetics, National Institute of Health, Rabat, Morocco.
    Background: In Algeria, the data on infertility and its various causes are rare. Recently, the introduction of assisted reproduction has allowed expecting that 300000 couples, which represent 7% of couples of reproductive age, face difficulty conceiving a child. Knowing that most idiopathic cases are likely to be due to chromosomal abnormalities, we aimed to investigate genetic defects by karyotype analysis in Algerian infertile men, using peripheral blood lymphocytes. Read More

    The investigation of children and adolescents with abnormalities of pubertal timing.
    Ann Clin Biochem 2017 Jan 28;54(1):20-32. Epub 2016 Sep 28.
    4 Department of Paediatric Endocrinology, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
    Concerns with pubertal development are common and can cause considerable distress to patients and their carers. Many presentations reflect normal variations of pubertal timing and primarily require reassurance, although patients may opt for interventions. Other presentations need active management to avoid significant adverse effects on growth and psychosocial development. Read More

    The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells.
    Stem Cell Reports 2016 Aug;7(2):279-91
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. Electronic address:
    Spermatogenesis originates from self-renewal of spermatogonial stem cells (SSCs). Previous studies have reported conflicting roles of gonadotropic pituitary hormones in SSC self-renewal. Here, we explored the role of hormonal regulation of SSCs using Fshb and Lhcgr knockout (KO) mice. Read More

    Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats.
    Environ Toxicol 2017 Apr 22;32(4):1273-1289. Epub 2016 Jul 22.
    Laboratory of Reproductive and Developmental Biology and Toxicology, Department of Morphology, Institute of Biosciences, Univ Estadual Paulista-UNESP, Distrito De Rubião Jr S/N, Botucatu, Sao Paulo, 18618-970, Brazil.
    Parabens are hormonally active chemicals widely used as preservatives in foods and are frequently detected in human fluids and tissues. Therefore, the objective of this study was to determine the effects of maternal butyl paraben (BP) exposure on male sexual development. Pregnant Wistar rats received corn oil (control group), or BP at doses of 10, 100, or 200 mg/kg, subcutaneously, from gestational day 12 until postnatal day 21. Read More

    Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism.
    J Pediatr Urol 2016 Aug 27;12(4):238.e1-6. Epub 2016 May 27.
    Institute for Cryptorchidism Research, Kindermedizinisches Zentrum, Liestal, Switzerland.
    Introduction: A transient increase in gonadotropins and testosterone during mini-puberty causes gonocytes to differentiate into Ad spermatogonia, which establish male germ cell memory and male-specific DNA methylation pathways. Over half of patients with unilateral cryptorchidism and the majority of patients with bilateral cryptorchidism display an abnormal spermiogram, which indicates that unilateral cryptorchidism is a bilateral disease; therefore, it represents a serious andrological problem. The aim of this study was to evaluate relationships between hormonal parameters and testicular biopsy findings in boys with cryptorchidism. Read More

    46 XX karyotype during male fertility evaluation; case series and literature review.
    Asian J Androl 2017 Mar-Apr;19(2):168-172
    Cleveland Clinic Foundation, Department of Urology, Cleveland, Ohio, USA.
    Forty-six XX disorder of sex development is an uncommon medical condition observed at times during the evaluation of a man's fertility. The following is a case series and literature review of phenotypically normal men diagnosed with this karyotype. Our goal is to comprehend the patients' clinical presentation as well as their laboratory results aiming to explore options available for their management. Read More

    Hormone-Based Treatments in Subfertile Males.
    Curr Urol Rep 2016 Aug;17(8):56
    Division of Urology, Department of Surgery, University of Utah Health Care, 30 N 1900 E, Rm 3B420, Salt Lake City, UT, 84132, USA.
    Subfertility is defined as the condition of being less than normally fertile though still capable of effecting fertilization. When these subfertile couples seek assistance for conception, a thorough evaluation of male endocrine function is often overlooked. Spermatogenesis is a complex process where even subtle alterations in this process can lead to subfertility or infertility. Read More

    [LH-FSH ratio and Polycystic Ovary Syndrome: A forgotten test?].
    Ginecol Obstet Mex 2016 Feb;84(2):84-94
    Objective: To identify the predictive value of LH-FSH ratio in the Polycystic Ovary Syndrome diagnosis and to evaluate its role according PCOS phenotypes.

    Material And Method: A descriptive, comparative, observational, prospective study of PCOS patients and its controls. All participants received a questionnaire and underwent a physical and transvaginal ultrasound examination. Read More

    Clinical features and management of 33 patients with 46,XX pure gonadal dysgenesis.
    Gynecol Endocrinol 2016 Dec 2;32(12):995-998. Epub 2016 Jun 2.
    a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing , China and.
    The objective of the study is to summarize the clinical characteristics of 33 patients' cohort (46,XX pure gonadal dysgenesis, 46,XX PGD), discuss the management, and propose treatment suggestions. Patients' information, medical history, and medical records were obtained. All patients were closely followed up. Read More

    Double separate versus contiguous pituitary adenomas: MRI features and endocrinological follow up.
    Pituitary 2016 Oct;19(5):472-81
    Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, 12605 E. 16th Avenue, Aurora, CO, 80045, USA.
    Purpose: Double pituitary adenomas are defined as two adenomas within a gland. These have distinct light microscopic and immunohistochemical features and may be clearly-separate or contiguous. Most reports have focused on the various hormonal combinations in double tumors rather than on any potential increased risk for residual mass or endocrinopathy. Read More

    The Study of Gonadal Hormonal Abnormalities and Sexual Dysfunction in HIV Positive Females: An Exploratory Study.
    J Clin Diagn Res 2016 Apr 1;10(4):OC11-4. Epub 2016 Apr 1.
    Research Scholar, Department of Clinical Pharmacy, JSS Medical College and Hospital , SS Nagar, Mysore, Karnataka, India .
    Introduction: Every endocrine gland has been reported to be affected at varying rates in HIV. HIV is a highly stigmatized chronic disease with a substantial co-occurrence of mental and sexual health problems; however the sexual health problems in women have not been extensively studied.

    Aim: To study the gonadal hormonal abnormalities and sexual dysfunction in HIV positive female patients and its possible association. Read More

    Human chorionic gonadotropin stimulation gives evidence of differences in testicular steroidogenesis in Klinefelter syndrome, as assessed by liquid chromatography-tandem mass spectrometry.
    Eur J Endocrinol 2016 Jun;174(6):801-11
    Unit of EndocrinologyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of MedicineEndocrinology, Metabolism and Geriatrics, Azienda USL of Modena, Modena, Italy Center for Genomic ResearchUniversity of Modena and Reggio Emilia, Modena, Italy.
    Background: Men with Klinefelter syndrome (KS) show hypergonadotropic hypogonadism, but the pathogenesis of hypotestosteronemia remains unclear. Testicular steroidogenesis in KS men was evaluated over three decades ago after human chorionic gonadotropin (hCG) stimulation, but inconclusive results were obtained. Intriguingly, some recent studies show increased intratesticular testosterone concentrations in men with KS. Read More

    Hypothalamic-pituitary, ovarian and adrenal contributions to polycystic ovary syndrome.
    Best Pract Res Clin Obstet Gynaecol 2016 Nov 1;37:80-97. Epub 2016 Apr 1.
    The Leeds Centre for Reproductive Medicine, Seacroft Hospital, York Road, Leeds LS14 6UH, UK. Electronic address:
    Polycystic ovary syndrome (PCOS) is a prevalent heterogeneous disorder linked with disturbances of reproductive, endocrine and metabolic function. The definition and aetiological hypotheses of PCOS are continually developing to incorporate evolving evidence of the syndrome, which appears to be both multifactorial and polygenic. The pathophysiology of PCOS encompasses inherent ovarian dysfunction that is strongly influenced by external factors including the hypothalamic-pituitary axis and hyperinsulinaemia. Read More

    Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial.
    Lancet 2016 Jun 27;387(10038):2614-21. Epub 2016 Apr 27.
    Institute of Metabolism and Systems Research and Tommy's National Centre for Miscarriage Care and Research, University of Birmingham, Birmingham, UK.
    Background: The success rate of in-vitro fertilisation (IVF) remains low and many women undergo multiple treatment cycles. A previous meta-analysis suggested hysteroscopy could improve outcomes in women who have had recurrent implantation failure; however, studies were of poor quality and a definitive randomised trial was needed. In the TROPHY trial we aimed to assess whether hysteroscopy improves the livebirth rate following IVF treatment in women with recurrent failure of implantation. Read More

    Combination of Klinefelter Syndrome and Acromegaly: A Rare Case Report.
    Medicine (Baltimore) 2016 Apr;95(17):e3444
    From the Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University (HF, JX, HF, LZ); and Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences (CAMS) (HW), Beijing, China.
    Klinefelter syndrome (KS) is the most common chromosomal aneuploidy in male population, which demonstrates an unusual association with acromegaly. We herein present a rare case involving the confirmation of KS 2 years after surgical treatment for acromegaly.A 27-year-old man presented with an acromegalic appearance. Read More

    Efficacy and safety of frozen-thawed embryo transfer in women aged 35 to 42 years from the PURSUE randomized clinical trial.
    Fertil Steril 2016 Aug 16;106(2):300-305.e5. Epub 2016 Apr 16.
    Merck & Co., Inc., Kenilworth, New Jersey.
    Objective: To examine the efficacy and safety of frozen-thawed embryo transfer (FTET) cycles with supernumerary embryos cryopreserved during a randomized clinical trial (PURSUE).

    Design: Follow-up clinical study.

    Setting: In vitro fertilization (IVF) centers. Read More

    Modifiable Factors Associated With Aging Phenotypes Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia.
    J Clin Oncol 2016 Jul 21;34(21):2509-15. Epub 2016 Mar 21.
    Carmen L. Wilson, Wassim Chemaitilly, Kendra E. Jones, Sue C. Kaste, Deo Kumar Srivastava, Rohit P. Ojha, Yutaka Yasui, Ching-Hon Pui, Leslie L. Robison, Melissa M. Hudson, and Kirsten K. Ness, St Jude Children's Research Hospital; Sue C. Kaste and Ching-Hon Pui, University of Tennessee Health Sciences Center, Memphis, TN.
    Purpose: Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for low bone mineral density (BMD) and frail health, outcomes potentially modifiable by altering health behaviors and/or treating endocrine abnormalities. We evaluated associations between lifestyle and hormonal deficits with risk of low BMD and frailty among survivors of ALL.

    Patients And Methods: Participants included 862 survivors of ALL (median age, 31. Read More

    Valproic Acid Metabolism and its Consequences on Sexual Functions.
    Curr Drug Metab 2016 ;17(6):573-81
    Department of Medicine, S. Anna Hospital, via Ravona, San Fermo della Battaglia, 22020, Italy.
    Background: Valproic acid (VPA) is a broad spectrum antiepileptic drug (AED) that is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies. Available data suggest that menstrual disorders and certain endocrine manifestations of reproductive system disorders may be more common in women treated with VPA than in those treated with other AEDs.

    Methods: A PubMed search for MEDLINE was undertaken to look for studies using the terms "VPA metabolism", "VPA and sexual functions in men", "VPA and sexual functions in women" and "VPA metabolism and endocrine disorders" as key words. Read More

    Salvage hormonal therapy after failed microdissection testicular sperm extraction: A multi-institutional prospective study.
    Int J Urol 2016 Jun 14;23(6):496-500. Epub 2016 Mar 14.
    Department of Urology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
    Objective: To validate the efficacy of salvage hormonal therapy in men with non-obstructive azoospermia at their second microdissection testicular sperm extraction.

    Methods: This was a multi-institutional study registered at the Japanese University Hospital Medical Information Network clinical trial center. After 1 month of human chorionic gonadotropin therapy (5000 IU, three times a week), patients were treated with recombinant human follicle-stimulating hormone (150 IU, three times a week) and human chorionic gonadotropin for the next 3 months. Read More

    Triple X syndrome and puberty: focus on the hypothalamus-hypophysis-gonad axis.
    Fertil Steril 2016 Jun 4;105(6):1547-53. Epub 2016 Mar 4.
    Department of Health Sciences, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
    Objective: To evaluate the hypothalamus-hypophysis-gonad axis in a cohort of children and adolescents with nonmosaic triple X syndrome.

    Design: Cross-sectional study with retrospective analysis.

    Setting: University pediatric hospital. Read More

    Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy.
    Tohoku J Exp Med 2016 ;238(3):197-203
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine.
    Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma. There have been only a limited number of reports regarding pituitary dysfunction associated with IVLBCL. We present a 71-year-old woman with hypopituitarism without any hypothalamic/pituitary abnormalities as assessed by magnetic resonance imaging. Read More

    The effect of epilepsy and antiepileptic drugs on sexual, reproductive and gonadal health of adults with epilepsy.
    Expert Rev Clin Pharmacol 2016 Jun 21;9(6):807-19. Epub 2016 Mar 21.
    a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.
    Epilepsy is a common chronic medical illness. Hyposexuality is the most frequent abnormality in men and women with epilepsy. In men with epilepsy, hypoandrogenimia, hypogonadism and sperm abnormalities are common. Read More

    A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7Δ) Asn(24Δ)) FSHβ subunit fails to rescue Fshb null mice.
    Mol Cell Endocrinol 2016 May 19;426:113-24. Epub 2016 Feb 19.
    Department of Molecular and Integrative Physiology; Center for Reproductive Sciences, Institute for Reproductive Health and Regenerative Medicine; Department of Pathology and Laboratory Medicine; Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address:
    Follicle-stimulating hormone (FSH) is a gonadotrope-derived heterodimeric glycoprotein. Both the common α- and hormone-specific β subunits contain Asn-linked N-glycan chains. Recently, macroheterogeneous FSH glycoforms consisting of β-subunits that differ in N-glycan number were identified in pituitaries of several species and subsequently the recombinant human FSH glycoforms biochemically characterized. Read More

    Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults.
    Andrology 2016 Jan;4(1):87-94
    Centre of Reproductive Medicine and Andrology, Department of Clinical Andrology, University of Muenster, Muenster, Germany.
    Germ cell and Sertoli cell proliferation and maturation in human testes occur in three main waves, during the late fetal and early neonatal period and at early puberty. They are triggered by periods of increased activity of the hypothalamic-pituitary-gonadal (HPG) axis. In hypogonadotropic hypogonadism (HH), these processes are variably disturbed. Read More

    Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure.
    J Clin Endocrinol Metab 2016 Mar 6;101(3):953-61. Epub 2016 Jan 6.
    Department of Medicine (L.D.T., A.D.N., E.S., M.S.R., M.G., A.F., C.F.), Unit of Andrology and Reproductive Medicine, University of Padova, 35128 Padova, Italy; Clinical Genetics Unit (D.Z.), Department of Woman and Child Health, University of Padova, 35128 Padova, Italy; and Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences (N.T.), University of Messina, 98124 Messina, Italy.
    Context: The G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. Read More

    Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men.
    PLoS One 2016 4;11(1):e0146304. Epub 2016 Jan 4.
    The Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
    Objective: This prospective study was designed to investigate the relationship between lipids levels in both serum and seminal plasma and semen parameters.

    Methods: 631 subfertile men were enrolled. Their obesity-associated markers were measured, and semen parameters were analyzed. Read More

    Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome.
    JAMA Dermatol 2016 Apr;152(4):391-8
    Department of Dermatology, University of California, San Francisco.
    Importance: Understanding of the associations among cutaneous findings, systemic abnormalities, and fulfillment of the diagnostic criteria in women suspected of having polycystic ovary syndrome (PCOS) is incomplete.

    Objective: To identify cutaneous and systemic features of PCOS that help distinguish women who do and do not meet the diagnostic criteria.

    Design, Setting, And Participants: Retrospective cross-sectional study of a racially diverse referred sample of women seen at the University of California, San Francisco, Polycystic Ovary Syndrome Multidisciplinary Clinic over a 6-year period between May 18, 2006, and October 25, 2012. Read More

    Klinefelter syndrome with low gonadotropin levels.
    BMJ Case Rep 2015 Dec 29;2015. Epub 2015 Dec 29.
    Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India.
    Klinefelter syndrome is usually characterised by the presence of a eunuchoid body habitus and testes that are usually small and firm, with low testosterone, and elevated luteinising hormone and follicle-stimulating hormone levels, consistent with hypergonadotropic hypogonadism. Low levels of gonadotropins in karyotypically proven cases are not expected, they are extremely rare occurrences. We report a case of a patient who was diagnosed to have Klinefelter syndrome (47 XXY) with low gonadotropin levels. Read More

    Activin Decoy Receptor ActRIIB:Fc Lowers FSH and Therapeutically Restores Oocyte Yield, Prevents Oocyte Chromosome Misalignments and Spindle Aberrations, and Increases Fertility in Midlife Female SAMP8 Mice.
    Endocrinology 2016 Mar 29;157(3):1234-47. Epub 2015 Dec 29.
    Pregmama, LLC (L.R.B.), Gaithersburg, Maryland 20886; Departments of Epidemiology and Public Health (L.R.B., A.C.L.M., I.M.), Obstetrics, Gynecology, and Reproductive Sciences (C.L.C.), and Anatomy and Neurobiology (I.M.), University of Maryland School of Medicine, Baltimore, Maryland 21201; Departments of Molecular Biology and Genetics (S.-J.L.) and Gynecology and Obstetrics, Johns Hopkins University School of Medicine (L.R.B.), Baltimore, Maryland 21205; and Department of Veterinary Integrative Biosciences (L.R.B.), Texas A&M College of Veterinary Medicine, College Station, Texas 77843.
    Women of advanced maternal age (AMA) (age ≥ 35) have increased rates of infertility, miscarriages, and trisomic pregnancies. Collectively these conditions are called "egg infertility." A root cause of egg infertility is increased rates of oocyte aneuploidy with age. Read More

    Evaluation of Microdissection Testicular Sperm Extraction Results in Patients with Non-Obstructive Azoospermia: Independent Predictive Factors and Best Cutoff Values for Sperm Retrieval.
    Urol J 2015 Dec 23;12(6):2436-43. Epub 2015 Dec 23.
    Department of Urology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Purpose: Testicular sperm extraction (TESE) for intracytoplasmic sperm injection (ICSI) was first introduced for the treatment of non-obstructive azoospermia. This study was conducted to detect predictive factors affecting the success of microTESE.

    Materials And Methods: We retrospectively evaluated the results of 191 cases who underwent microTESE. Read More

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