8,545 results match your criteria Folic Acid Deficiency


Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration.

Kidney Int 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Matrix metalloproteinase-7 (MMP-7) is a secreted endopeptidase that degrades a broad range of substrates. Recent studies have identified MMP-7 as an early biomarker to predict severe acute kidney injury (AKI) and poor outcomes after cardiac surgery; however, the role of MMP-7 in the pathogenesis of AKI is unknown. In this study, we investigated the expression of MMP-7 and the impact of MMP-7 deficiency in several models of AKI. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.043DOI Listing

Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway.

Ital J Pediatr 2019 Mar 14;45(1):37. Epub 2019 Mar 14.

Department of Pediatrics, Tianjin Children's Hospital, No.238 Longyan Road, Beichen District, Tianjin, 300134, China.

Background: Neural tube defects (NTDs) are birth defects of the brain, spine, or spinal cord invoked by the insufficient intake of folic acid in the early stages of pregnancy and have a complex etiology involving both genetic and environmental factors. So the study aimed to explore the association between alterations in maternal one-carbon metabolism and NTDs in the offspring.

Methods: We conducted a case-control study to get a deeper insight into this association, as well as into the role of genetic polymorphisms. Read More

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http://dx.doi.org/10.1186/s13052-019-0630-1DOI Listing
March 2019
1 Read

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Mar 12. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
March 2019
2 Reads

Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14808

Department of Physical Medicine and Rehabilitation, China Medical University Hospital.

Rationale: Bariatric surgery is the recommended treatment for morbid obesity because of its rapid and sustained body weight loss effect. Nutrient deficiency-related neurological complications after bariatric surgery are often disabling. Thus, early recognition of these complications is important. Read More

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http://dx.doi.org/10.1097/MD.0000000000014808DOI Listing

Vitamin B12 and folic acid associated megaloblastic anemia: Could it mislead the diagnosis of breast cancer?

Int J Vitam Nutr Res 2019 Mar 11:1-6. Epub 2019 Mar 11.

1 University of Health Sciences, Tepecik Training and Research Hospital, Department of Medical Biochemistry, Izmir, Turkey.

CA 15-3 is a tumor-associated antigen and is overexpressed in breast tumors, and may also be high in some other non-cancerous conditions. The aim of this study was to investigate the effect of megaloblastic anemia due to vitamin B12 or folic acid deficiency on the levels of tumor markers. Five-year patient data were retrospectively analyzed. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000555
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http://dx.doi.org/10.1024/0300-9831/a000555DOI Listing
March 2019
2 Reads

Maximising benefits and minimising adverse effects of micronutrient interventions in low- and middle-income countries.

Authors:
Kaleab Baye

Proc Nutr Soc 2019 Mar 11:1-7. Epub 2019 Mar 11.

Center for Food Science and Nutrition, Addis Ababa University,Addis Ababa,Ethiopia.

Micronutrient deficiencies are widespread and disproportionately affect women and children in low- and middle-income countries (LMIC). Among various interventions, food fortification and supplementation with micronutrients have been proven to be cost-effective. The aim of the present paper is to review existing literature to assess risks of excessive intake in LMIC to then highlight programmatic changes required to maximise benefits of micronutrient interventions while minimising risks of adverse effects. Read More

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http://dx.doi.org/10.1017/S0029665119000557DOI Listing
March 2019
1 Read

Subacute oral administration of folic acid elicits anti-inflammatory response in a mouse model of allergic dermatitis.

J Nutr Biochem 2019 Jan 26;67:14-19. Epub 2019 Jan 26.

Pathology, Toxicology Division, The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki, Japan. Electronic address:

Folic acid (FA) deficiency is associated with several health problems, including megaloblastic anemia and fetal neural tube defects. Therefore, supplementation with FA is strongly recommended by governments worldwide. Recent published reports indicate that FA functions in immune system maintenance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183055
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http://dx.doi.org/10.1016/j.jnutbio.2019.01.009DOI Listing
January 2019
2 Reads

Recreational Nitrous Oxide Abuse Causing Ischemic Stroke in a Young Patient: A Rare Case Report.

Cureus 2018 Dec 21;10(12):e3761. Epub 2018 Dec 21.

Internal Medicine, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, IND.

Hyperhomocysteinemia has been associated with an increased risk of systemic atherosclerosis, cardiovascular disease, and stroke. It can result from an impaired homocysteine metabolism resulting from a dietary deficiency of folic acid, vitamin B6, and vitamin B12 or as a result of genetic predispositions due to impaired gene function involved in the methionine and homocysteine metabolism. Nitrous oxide use can also lead to hyperhomocysteinemia by irreversibly oxidizing the cobalt atom of vitamin B12, which results in an inhibition of the enzyme methionine synthase. Read More

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http://dx.doi.org/10.7759/cureus.3761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389023PMC
December 2018
1 Read

Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid.

Int J Mol Sci 2019 Feb 23;20(4). Epub 2019 Feb 23.

Université de Lorraine, Inserm U1256, NGERE, Faculté de Médecine, 9 avenue de la Forêt de Haye, F-54500 Vandoeuvre-lès-Nancy, France.

Vitamins B9 (folate) and B12 act as methyl donors in the one-carbon metabolism which influences epigenetic mechanisms. We previously showed that an embryofetal deficiency of vitamins B9 and B12 in the rat increased brain expression of let-7a and miR-34a microRNAs involved in the developmental control of gene expression. This was reversed by the maternal supply with folic acid (3 mg/kg/day) during the last third of gestation, resulting in a significant reduction of associated birth defects. Read More

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http://dx.doi.org/10.3390/ijms20040973DOI Listing
February 2019
2 Reads

[A comparative analysis of actual nutrition of children aged 9-10 years].

Vopr Pitan 2018 13;87(6):28-41. Epub 2018 Nov 13.

Kazakh Academy of Nutrition, Almaty, Republic of Kazakhstan.

Aim of the study is to carry out a comparative analysis of actual nutrition of children aged 9-10 years with different nutritional status, to asses relationships between Energy Value (EV) of diet, BMI and diet composition. The study covers two groups of children residing in Almaty - 80 children aged 9-10 years with obesity (40 boys and 40 girls) and 80 normal-weight children (40 boys and 40 girls). To determine the nutritional status of the children, diagnostic criteria such as BMI-for-Age Z-score tables of WHO growth standards have been used. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10064DOI Listing
November 2018
1 Read

Adequate or elevated dietary folate does not ameliorate the reduced antioxidant capacity induced by vitamin B deficiency in aged rats.

Int J Vitam Nutr Res 2019 Feb 12:1-10. Epub 2019 Feb 12.

1 Department of Pharmaceutical and Health Sciences. Universidad CEU San Pablo, CEU Universities, Madrid, Spain.

Folate could have an antioxidant role but also may be detrimental under vitamin B deficiency. The aim was to investigate the effect of different dietary folic acid (FA) levels, on oxidative stress in B induced deficient aged rats. Thirty-five male aged Sprague-Dawley rats, were fed either a vitamin B deficient (n = 27) or a control diet (n = 8) during eight weeks. Read More

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http://dx.doi.org/10.1024/0300-9831/a000537DOI Listing
February 2019
2 Reads

Excess nutritional risk in infants and toddlers in a Spanish city.

Int J Vitam Nutr Res 2019 Feb 12:1-11. Epub 2019 Feb 12.

1 Universitat Rovira i Virgili, Reus, Tarragona, Spain.

Adequate dietary intake is vital for infants' growth and development. The aim was to analyse food consumption and energy and nutrient intakes in a group of healthy Spanish infants and toddlers. Cross-sectional study. Read More

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http://dx.doi.org/10.1024/0300-9831/a000530DOI Listing
February 2019
1 Read

Compliance with iron folic acid and associated factors among pregnant women through pill count in Hawassa city, South Ethiopia: a community based cross-sectional study.

Reprod Health 2019 Feb 8;16(1):14. Epub 2019 Feb 8.

College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Iron deficiency anemia during pregnancy is a public health problem across the globe that adversely affects maternal and perinatal outcome. World Health Organization recommends that universal iron folic acid supplementation of pregnant women. Therefore, the aim of this study was to determine compliance and identify factors associated with Iron folic acid among pregnant women. Read More

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http://dx.doi.org/10.1186/s12978-019-0679-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367743PMC
February 2019
3 Reads

Paraquat exposure increases oxidative stress within the dorsal striatum of male mice with a genetic deficiency in one-carbon metabolism.

Toxicol Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6.

Paraquat is a herbicide that is commonly used worldwide. Exposure to paraquat results in Parkinson's disease (PD)-like symptoms including dopaminergic cell loss. Nutrition has also been linked in the pathogenesis of PD, such as reduced levels of folic acid, a B-vitamin and component of one-carbon metabolism. Read More

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http://dx.doi.org/10.1093/toxsci/kfz034DOI Listing
February 2019
4 Reads

Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis.

Mol Ther 2019 Mar 12;27(3):493-506. Epub 2019 Jan 12.

Food Science & Human Nutrition Department, University of Florida, Gainesville, FL, USA. Electronic address:

Nanoparticles (NPs) have been utilized to deliver drugs to the intestinal epithelium in vivo. Moreover, NPs derived from edible plants are less toxic than synthetic NPs. Here, we utilized ginger NP-derived lipid vectors (GDLVs) in a proof-of-concept investigation to test the hypothesis that inhibiting expression of divalent metal-ion transporter 1 (Dmt1) would attenuate iron loading in a mouse model of hereditary hemochromatosis (HH). Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.01.003DOI Listing
March 2019
2 Reads

Supplementation with dairy matrices impacts on homocysteine levels and gut microbiota composition of hyperhomocysteinemic mice.

Eur J Nutr 2019 Jan 30. Epub 2019 Jan 30.

Research Centre for Food and Nutrition, CREA (Council for Agricultural Research and Economics), Via Ardeatina 546, 00178, Rome, Italy.

Purpose: Several studies highlighted a correlation between folic acid deficiency and high plasma homocysteine concentration, considered a risk factor for multifactorial diseases. Natural folates represent an emerging alternative strategy to supplementation with synthetic folic acid, whose effects are controversial. The present work was, therefore, performed in hyperhomocysteinemic mice to study the impact of supplementation with dairy matrices containing natural folates on plasma homocysteine levels and faecal microbiota composition. Read More

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http://dx.doi.org/10.1007/s00394-019-01911-yDOI Listing
January 2019
3 Reads

Demand and supply factors of iron-folic acid supplementation and its association with anaemia in North Indian pregnant women.

PLoS One 2019 30;14(1):e0210634. Epub 2019 Jan 30.

Department of Biostatistics, St. John's Medical College, Bangalore, India.

Anaemia prevalence in pregnant women of India declined from 57.9% to 50.3% from National Family Health Survey (NFHS)-3 to NFHS-4. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353128PMC
January 2019
9 Reads

Adherence to Iron-Folate Supplementation and Associated Factors among Pastoralist's Pregnant Women in Burji Districts, Segen Area People's Zone, Southern Ethiopia: Community-Based Cross-Sectional Study.

Int J Reprod Med 2018 31;2018:2365362. Epub 2018 Dec 31.

Department of Midwifery, College of Health Sciences, Arba Minch, Ethiopia.

Background: Iron deficiency anemia among pregnant women is one of the most common public health problems in developing country particularly in Ethiopia. Iron/folic acid supplementation with optimal adherence is the main cost-effective strategy for prevention and control of iron deficiency anemia in pregnant women. However, level of adherence to iron/folic acid supplementation and its associated factors were not well identified in study area. Read More

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http://dx.doi.org/10.1155/2018/2365362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333009PMC
December 2018
2 Reads

Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study.

J Nutr 2019 Jan 24. Epub 2019 Jan 24.

Departments of Epidemiology, Human Genetics, and Environmental Sciences.

Background: The risk of neural tube defect (NTD)-affected pregnancies is reduced with adequate folic acid intake during early pregnancy. However, NTDs have been observed among offspring of women with adequate folic acid intake. Some of these women are possibly not absorbing enough folic acid. Read More

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http://dx.doi.org/10.1093/jn/nxy246DOI Listing
January 2019
1 Read
3.875 Impact Factor

Nutritional status among women whose pregnancy outcome was afflicted with neural tube defects in Tigray region of Ethiopia.

Brain Dev 2019 Jan 14. Epub 2019 Jan 14.

Department of Nutrition, School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Background: Nutritional deficiency in pregnant women is a confirmed cause of neural tube defects (NTDs). Alongside to this background, We sought to determine the nutritional status and level of awareness on the issue of the NTDs as well as folic acid (FA) utilization among women who born infants with NTDs in Tigray region of Ethiopia.

Method: A standard interviewer and a food frequency questionnaire was used to obtain information from mothers of cases with neural tube defects (n = 205) and their controls (n = 412). Read More

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http://dx.doi.org/10.1016/j.braindev.2018.12.005DOI Listing
January 2019
3 Reads

Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity.

Curr Dev Nutr 2019 Jan 3;3(1):nzy070. Epub 2018 Oct 3.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA.

Background: Folate and choline are essential methyl donor nutrients throughout the life span; however, the adverse effects of combined deficiency on early growth, intestinal epithelial morphology, and the gut microbiome remain only partially understood.

Objectives: We investigated the effects of dietary folate and choline deficiency on early growth, small intestinal (SI) epithelial architecture, and the gut microbiota of mice. To explore potential mechanisms for adverse effects on gut epithelial morphology, we also evaluated gene expression and DNA methylation in mouse intestinal epithelial organoids (enteroids) maintained in methyl donor-deficient (MDD) conditions. Read More

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http://dx.doi.org/10.1093/cdn/nzy070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324351PMC
January 2019
2 Reads

In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).

Alcohol 2019 Mar 24;75:113-121. Epub 2018 Jul 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University, College of Medicine, Seoul, Republic of Korea. Electronic address:

In reference to the auditory manifestation of fetal alcohol syndrome, previous work has preferentially focused on the deviant neural development of the auditory system. Changes in the sensory hair cell, the ultimate sensory organ, were not well understood. In this study, we carried out an in vivo assessment of the embryonic hair cell changes on the lateral line of zebrafish upon exposure to various ethanol concentrations (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07418329173094
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http://dx.doi.org/10.1016/j.alcohol.2018.07.008DOI Listing
March 2019
7 Reads

Analytical quality assessment and method comparison of immunoassays for the measurement of serum cobalamin and folate in dogs and cats.

J Vet Diagn Invest 2019 Mar 13;31(2):164-174. Epub 2019 Jan 13.

Diagnostic Laboratories, Langford Vets, Bristol Veterinary School, University of Bristol, Langford, Bristol, UK (McLeish, Burt).

Serum cobalamin and folate are often measured in cats and dogs as part of laboratory testing for intestinal disease, small intestinal dysbiosis, or exocrine pancreatic deficiency. We performed an analytical validation of human immunoassays for cobalamin and folate measurement (AIA-900 analyzer, Tosoh Bioscience) and compared results with those obtained using chemiluminescence assays (Immulite 2000 analyzer, Siemens Medical Solutions Diagnostics). Accuracy, precision, total observable error (TE%), and σ values were calculated for the immunoassays. Read More

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http://journals.sagepub.com/doi/10.1177/1040638718824073
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http://dx.doi.org/10.1177/1040638718824073DOI Listing
March 2019
9 Reads

Anemia in Patients with Diabetic Foot Ulcer: Effects on Diabetic Microvascular Complications and Related Conditions.

Endocr Metab Immune Disord Drug Targets 2019 01 11. Epub 2019 Jan 11.

Cukurova University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Adana. Turkey.

Objective: We aimed to investigate the etiology and prevalence of anemia in patients with diabetic foot ulcers and the relationship between both microvascular complications and related conditions and anemia.

Method: We retrospectively collected and evaluated the data of 225 patients with diabetic foot ulcer followed at our clinic. The demographic characteristics of the patients were analyzed. Read More

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http://www.eurekaselect.com/168896/article
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http://dx.doi.org/10.2174/1871530319666190111121913DOI Listing
January 2019
8 Reads

The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

Neurology Clinic, Department of Medical, Surgical, and Health Sciences, University of Trieste, 34149 Trieste, Italy.

Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin status. Elevated plasma levels of Hcy can be caused by deficiency of either vitamin B12 or folate. Read More

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http://dx.doi.org/10.3390/ijms20010231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337226PMC
January 2019
2 Reads

Maternal and Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Increases Infants' Iron Status at 18 Months of Age in a Semiurban Setting in Ghana: A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Controlled Trial.

J Nutr 2019 Jan;149(1):149-158

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Interventions are needed to address iron deficiency in low-income settings.

Objective: This secondary outcome analysis aimed to compare the hemoglobin (Hb) and iron status [zinc protoporphyrin (ZPP)] of children born to women enrolled in the iLiNS-DYAD trial in Ghana.

Methods: Women ≤20 wk pregnant (n = 1320) were assigned to receive 60 mg Fe/d and 400 µg folic acid/d until delivery and placebo thereafter, and no supplementation for infants (IFA group); or multiple micronutrients containing 20 mg Fe/d until 6 mo postpartum and no supplementation for infants (MMN); or small-quantity lipid-based nutrient supplements (SQ-LNSs) containing 20 mg Fe/d until 6 mo postpartum, and SQ-LNSs for infants from 6 to 18 mo of age (LNS). Read More

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http://dx.doi.org/10.1093/jn/nxy225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351141PMC
January 2019
4 Reads

Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs.

Vet J 2019 Jan 12;243:15-20. Epub 2018 Nov 12.

LDHVet Laboratory, Department of Biology, Pathology and Food Science, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, F-44307, France.

Exocrine pancreatic insufficiency (EPI) in dogs is a gastrointestinal condition leading to a severe impairment of nutrient absorption. The disease is frequently associated with vitamin disturbances especially regarding cobalamin and folate. Dogs with EPI need daily expensive supportive treatment. Read More

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http://dx.doi.org/10.1016/j.tvjl.2018.11.003DOI Listing
January 2019
2 Reads

Roles of folate in skeletal muscle cell development and functions.

Arch Pharm Res 2019 Jan 1. Epub 2019 Jan 1.

Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, 63beon-gil 2, Geumjeong-gu, Busan, 46241, Republic of Korea.

Folate is the generic term for both naturally occurring food folate and folic acid, the fully oxidized monoglutamate form of the vitamin that is used in dietary supplements and fortified foods. It is a water-soluble vitamin B9 and is important for health, growth, and development. As a precursor of various cofactors, folate is required for one-carbon donors in the synthesis of DNA bases and other essential biomolecules. Read More

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http://dx.doi.org/10.1007/s12272-018-1100-9DOI Listing
January 2019
1 Read

[Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of and genes].

Vopr Pitan 2018 26;87(2):17-23. Epub 2018 Feb 26.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The results of assessing the sufficiency of folic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFR gene polymorphism and rs9939609 FTO gene polymorphism. A total of 326 people were examined, including 74 men and 252 women aged 20 to 65 years. The results of determining the level of folic acid in blood serum showed insufficiency of this vitamin among the population of the Moscow region of the Russian Federation. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10014DOI Listing
February 2018
1 Read

The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects.

FASEB J 2018 Dec 28:fj201801536R. Epub 2018 Dec 28.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China.

Folate deficiency in early development leads to disturbance in multiple processes, including neurogenesis during which fibroblast growth factor (FGF) pathway is one of the crucial pathways. Whether folic acid (FA) directly affects FGF pathways to influence neurodevelopment and the possible mechanism remains unclear. In this study, we presented evidence that in human FA-insufficient encephalocele, the FGF pathway was interfered. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801536R
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http://dx.doi.org/10.1096/fj.201801536RDOI Listing
December 2018
16 Reads
5.043 Impact Factor

Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.

J Formos Med Assoc 2019 Feb 21;118(2):565-571. Epub 2018 Dec 21.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCAAG) and GPCA-negative AG (GPCAAG) patients.

Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCAAG, 780 GPCAAG patients, and 532 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183080
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http://dx.doi.org/10.1016/j.jfma.2018.12.005DOI Listing
February 2019
11 Reads

The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B: A Randomised Controlled Crossover Trial.

Nutrients 2018 Dec 21;11(1). Epub 2018 Dec 21.

Health & Biosecurity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), 5000 Adelaide, South Australia, Australia.

Whey protein isolate (WPI) is high in vitamin B and folate. These and other related markers (holotranscobalamin, methylmalonic acid and homocysteine) have been linked with cognitive health. This study explored the efficacy of WPI for improving cognitive function via delivery of vitamin B. Read More

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http://dx.doi.org/10.3390/nu11010019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357102PMC
December 2018
1 Read

Optic Nerve Degeneration and Reduced Contrast Sensitivity Due to Folic Acid Deficiency: A Behavioral and Electrophysiological Study in Rhesus Monkeys.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):6045-6056

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Purpose: The purpose of the research was to elucidate the role of folic acid (B9) deficiency in the development of nutritional optic neuritis and to characterize the neurophysiological consequences of optic nerve degeneration in the cortical visual system.

Methods: A combined behavioral and electrophysiological approach was applied to study luminance contrast sensitivity in two macaque monkeys affected by nutritional optic neuritis and in two healthy monkeys for comparison. For one monkey, a follow-up approach was applied to compare visual performance before onset of optic neuropathy, during the disease, and after treatment. Read More

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http://dx.doi.org/10.1167/iovs.18-24822DOI Listing
December 2018
1 Read

Hemolytic jaundice induced by pharmacological dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13588

Clinical Pharmacy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Rationale: Hemolysis induced by high dose ascorbic acid (AA) in patients with G6PD deficiency has been reported, but is rare. To our knowledge, this is the first reported case of a male with G6PD deficiency, coexpressed with cholecystolithiasis and cholecystitis, who developed extreme hemolysis and hyperbilirubinemia after receiving pharmacological doses ascorbic acid infusion.

Patient Concerns: A 27-year-old man history with glucose-6-phosphate dehydrogenase deficiency was admitted to our hospital because of cholecystolithiasis and cholecystitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319863PMC
December 2018
1 Read

Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study.

Int Urol Nephrol 2019 Feb 13;51(2):223-229. Epub 2018 Dec 13.

Andrology & STDs Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED.

Methods: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. Read More

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http://link.springer.com/10.1007/s11255-018-2055-y
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http://dx.doi.org/10.1007/s11255-018-2055-yDOI Listing
February 2019
9 Reads

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2019 Mar 13;9(1):51-70. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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http://link.springer.com/10.1007/s13555-018-0278-6
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http://dx.doi.org/10.1007/s13555-018-0278-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380979PMC
March 2019
27 Reads

[A Reversible Case of Korsakoff Syndrome in an Alcohol Dependent Patient].

Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.

LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität, Medizinische Fakultät Düsseldorf.

Alcohol dependent patients represent a high-risk group for vitamin deficiency, which could lead to variable cognitive dysfunctions and, as an extreme example, to an amnestic-confabulatory syndrome. In this case report, we report about an alcohol dependent 58-year-old patient without focal neurological symptoms with an amnestic-confabulatory syndrome. After substitution of thiamine, vitamin B12 and folic acid, cognitive symptoms completely vanish within a 22-month period of observation. Read More

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http://dx.doi.org/10.1055/a-0807-4290DOI Listing
December 2018
7 Reads

Dietary vitamin and mineral intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines.

Ginekol Pol 2018;89(11):581-586

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.

Objectives: Maintaining proper nutrition during pregnancy is crucial for pregnant women and especially for who have been diagnosed with type 1 diabetes mellitus (T1DM) or who develop gestational diabetes mellitus (GDM).

Material And Methods: To measure differences in vitamin and mineral intakes among women with normal pregnancies, pregnant women with GDM, and pregnant women with pre-gestational T1DM; and to assess the women's dietary intakes in comparison with Polish nutritional guidelines. The analysis was conducted among 83 pregnant women (29 GDM patients, 26 T1DM patients and 28 normal pregnancy participants) from whom we collected seven-day 24-hour dietary records during the second part of their pregnancies. Read More

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https://journals.viamedica.pl/ginekologia_polska/article/vie
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http://dx.doi.org/10.5603/GP.a2018.0100DOI Listing
February 2019
12 Reads

Association between seasonal serum folate levels and ultraviolet radiation.

J Photochem Photobiol B 2019 Jan 14;190:66-71. Epub 2018 Nov 14.

Photobiological Dermatology Laboratory, Medical Research Centre, Department of Medicine and Dermatology, Faculty of Medicine, University of Málaga, Málaga, Spain; Department of Dermatology, Virgen de la Victoria Hospital, Málaga, Spain.

UV radiation has been consistently reported to cause folate photodegradation in vitro and in human skin. Seasonal variations in UV radiation might explain seasonal changes in folate levels in blood. Yet, few studies have addressed this phenomenon. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.10.012DOI Listing
January 2019
1 Read

Epidemiology of anaemia in children, adolescent girls, and women in Bhutan.

Matern Child Nutr 2018 11;14 Suppl 4:e12740

Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Anaemia inhibits health and development in Bhutan. We estimated anaemia prevalence and explored risk factors in children and women using data from Bhutan's National Nutrition Survey 2015. Prevalence was calculated using life-stage-specific cut-offs adjusted for altitude and survey design. Read More

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http://dx.doi.org/10.1111/mcn.12740DOI Listing
November 2018
3 Reads

Relationship between cobalamin and folate deficiencies and anemia in dogs.

J Vet Intern Med 2019 Jan 29;33(1):106-113. Epub 2018 Nov 29.

Clinical Pathology, IDEXX Laboratories, New York, New York.

Background: Megaloblastic, nonregenerative anemia is a well-known consequence of cobalamin or folate deficiencies in humans but is not recognized in hypocobalaminemic or hypofolatemic dogs. Establishment of relationships between hypocobalaminemia or hypofolatemia and hematologic disease would encourage vitamin B testing, and potentially supplementation, in anemic dogs.

Objectives: To determine the prevalence of anemia in hypocobalaminemic or hypofolatemic dogs and to report the prevalence of hypocobalaminemia and hypofolatemia and nonregenerative anemia, macrocytosis, and anisocytosis in anemic dogs. Read More

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http://dx.doi.org/10.1111/jvim.15348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335522PMC
January 2019
19 Reads

Maternal postpartum plasma folate status and preterm birth in a high-risk US population.

Public Health Nutr 2018 Nov 29:1-11. Epub 2018 Nov 29.

1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.

Objective: While maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. Read More

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http://dx.doi.org/10.1017/S1368980018003221DOI Listing
November 2018
3 Reads

MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world.

Per Med 2019 01 23;16(1):35-49. Epub 2018 Nov 23.

Institute of Biomedical & Genetic Engineering (IB & GE), 24 Mauve Area, G9/1, Islamabad 44000, Pakistan.

Aim: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Methodology & results: Male infertility association of C665T and A1298C polymorphisms was explored, this topic is still debatable. Infertile men (232) and controls (114) were genotyped and statistically analyzed. Read More

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http://dx.doi.org/10.2217/pme-2018-0045DOI Listing
January 2019
12 Reads

Gender differences in homocysteine concentrations, a population-based cross-sectional study.

Nutr Metab Cardiovasc Dis 2019 01 21;29(1):9-14. Epub 2018 Sep 21.

Department of Medicine F - Recanati, Rabin Medical Center -Beilinson Hospital, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Background And Aims: High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine.

Methods And Results: Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000-2014. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.09.003DOI Listing
January 2019
10 Reads

A descriptive study of clinico-hematological profile of megaloblastic anemia in a tertiary care hospital.

Med J Armed Forces India 2018 Oct 27;74(4):365-370. Epub 2017 Dec 27.

Brig Med, HQ 12 Corps, C/o 56 APO, India.

Background: Megaloblastic Anemia (MA) is a relatively common disease, yet the data on prevalence of MA remains scarce. This study was conducted to study the prevalence and clinico-hematological profile of MA.

Methods: This was a cross-sectional study done on 1150 adult anemic patients. Read More

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http://dx.doi.org/10.1016/j.mjafi.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224687PMC
October 2018
20 Reads

Maternal folic acid deficiency stimulates neural cell apoptosis via miR-34a associated with Bcl-2 in the rat foetal brain.

Int J Dev Neurosci 2019 Feb 14;72:6-12. Epub 2018 Nov 14.

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183022
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http://dx.doi.org/10.1016/j.ijdevneu.2018.11.002DOI Listing
February 2019
20 Reads

Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management.

J Formos Med Assoc 2018 Nov 14. Epub 2018 Nov 14.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAS, namely minor, major, and herpetiform types, can be identified. RAS more commonly affects labial mucosa, buccal mucosa, and tongue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183074
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http://dx.doi.org/10.1016/j.jfma.2018.10.023DOI Listing
November 2018
10 Reads

Tailored One Anastomosis Gastric Bypass: 3-Year Outcomes of 94 Patients.

Obes Surg 2019 Feb;29(2):542-551

First Propaedeutic Surgical Clinic, Hippocratio Athens General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vassilissis Sophias Avenue, 115 27, Athens, Greece.

Background: One anastomosis gastric bypass (OAGB) claims its place among bariatric operations, proving itself a safe and effective procedure.

Methods: This is a retrospective analysis of prospectively collected data regarding 94 patients who underwent surgery in a single surgical unit. Tailoring of the biliopancreatic limb length decided upon preoperative BMI was applied. Read More

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http://link.springer.com/10.1007/s11695-018-3572-6
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http://dx.doi.org/10.1007/s11695-018-3572-6DOI Listing
February 2019
15 Reads