38,357 results match your criteria Folic Acid Deficiency


Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
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Effects of folic acid food fortification scenarios on the folate intake of a multi-ethnic pregnant population.

Public Health Nutr 2018 Dec 6:1-12. Epub 2018 Dec 6.

2The Centre for Longitudinal Research - He Ara ki Mua, School of Population Health (building 730, level 3), Tamaki Campus,University of Auckland,261 Morrin Road, St Johns, Auckland 1072,New Zealand.

Objective: To simulate effects of different scenarios of folic acid fortification of food on dietary folate equivalents (DFE) intake in an ethnically diverse sample of pregnant women.

Design: A forty-four-item FFQ was used to evaluate dietary intake of the population. DFE intakes were estimated for different scenarios of food fortification with folic acid: (i) voluntary fortification; (ii) increased voluntary fortification; (iii) simulated bread mandatory fortification; and (iv) simulated grains-and-rice mandatory fortification. Read More

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December 2018

In Vitro Cytotoxicity of Folate-Silica-Gold Nanorods on Mouse Acute Lymphoblastic Leukemia and Spermatogonial Cells.

Cell J 2019 Apr 18;21(1):14-26. Epub 2018 Nov 18.

Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objective: The purpose of this study was to evaluate in vitro cytotoxicity of gold nanorods (GNRs) on the viability of spermatogonial cells (SSCs) and mouse acute lymphoblastic leukemia cells (EL4s).

Materials And Methods: In this experimental study, SSCs were isolated from the neonate mice, following enzymatic digestion and differential plating. GNRs were synthesized, then modified by silica and finally conjugated with folic acid to form F-Si-GNRs. Read More

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Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets.

Fundam Clin Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.

The incidence of cardiovascular diseases in vegetarian individuals is lower than that in the general population. Nevertheless, individuals who adhere to vegan diets have a higher prevalence of hyperhomocysteinemia with eventual adverse effects on vascular reactivity. Creatine supplementation (CrS) reduces plasma homocysteine levels and enhances vascular reactivity in the microcirculation. Read More

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December 2018

Floral markers and biological activity of Saudi honey.

Saudi J Biol Sci 2018 Nov 29;25(7):1369-1374. Epub 2018 May 29.

Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

The objectives of this research were to identify certain chemical compounds that may be used as fingerprints of Saudi honey and to evaluate their antioxidant and antibacterial activities. Eleven Saudi 'monofloral' honey samples were analyzed and evaluated. Non-phenolic compounds, such as 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl 3-hydroxyhexanaote and 5-hydroxymethyl-2-furancarboxaldehyde were present in different types of tested honey samples. Read More

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November 2018

Bacterial folate biosynthesis and colorectal cancer risk: more than just a gut feeling.

Crit Rev Food Sci Nutr 2018 Dec 3:1-13. Epub 2018 Dec 3.

a Division of Human Nutrition and Health , Wageningen University & Research , Wageningen , The Netherlands.

Folate is a B-vitamin with an important role in health and disease. The optimal folate status with regard to human health remains controversial. A low intake of natural folate as well as excessive intake of synthetic folic acid, were previously linked to an increased risk of colorectal cancer or with aberrant molecular pathways related to carcinogenesis in some studies. Read More

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December 2018

Lanthanide-doped Hafnia Nanoparticles for Multimodal Theranostics: Tailoring the Physicochemical Properties and Interactions with Biological Entities.

ACS Appl Mater Interfaces 2018 Dec 5. Epub 2018 Dec 5.

High-Z metal oxide nanoparticles hold promise as imaging probes and radio-enhancers. Hafnium dioxide nanoparticles have recently entered clinical evaluation. Despite promising early clinical findings, the potential of HfO2 as a matrix for multimodal theranostics is yet to be developed. Read More

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December 2018
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Hypospermia Improvement in Dogs Fed on a Nutraceutical Diet.

ScientificWorldJournal 2018 1;2018:9520204. Epub 2018 Nov 1.

Research and Development Department, Forza10 USA Corp., Orlando, FL, USA.

Male dog infertility may represent a serious concern in the canine breeding market. The aim of this clinical evaluation was to test the efficacy of a commercially available nutraceutical diet, enriched with L-carnitine, zinc, omega-3 (N-3) fatty acids, beta-carotene, vitamin E, and folic acid, in 28 male dogs suffering from infertility associated with hypospermia. All dogs received the diet over a period of 100 days. Read More

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November 2018

Plasma metabolite profiles in healthy women differ after intervention with supplemental folic acid folate-rich foods.

J Nutr Sci 2018 26;7:e32. Epub 2018 Nov 26.

Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Public health authorities recommend all fertile women to increase their folate intake to 400 µg/d by eating folate-rich foods or by taking a folic acid supplement to protect against neural tube defects. In a previous study it was shown that folate-rich foods improved folate blood status as effectively as folic acid supplementation. The aim of the present study was to investigate, using NMR metabolomics, the effects of an intervention with a synthetic folic acid supplement native food folate on the profile of plasma metabolites. Read More

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November 2018

Could FA-PG-SPIONs act as a hyperthermia sensitizing agent? An in vitro study.

J Therm Biol 2018 Dec 14;78:73-83. Epub 2018 Sep 14.

Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.

The therapeutic effect of polyglycerol coated iron oxide nanoparticles (PG-SPIONs, non-targeted nanoparticles) and folic acid-conjugated polyglycerol coated iron oxide nanoparticles (FA-PG-SPIONs, targeted nanoparticles) in combination with hyperthermia on viability of HeLa cells was investigated. It was observed that coated and uncoated SPIONs have spherical shapes with an average diameter of 17.9 ± 2. Read More

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December 2018
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Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells.

Photodiagnosis Photodyn Ther 2018 Dec 27;24:324-331. Epub 2018 Oct 27.

Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address:

In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. Read More

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December 2018
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Association between seasonal serum folate levels and ultraviolet radiation.

J Photochem Photobiol B 2018 Nov 14;190:66-71. Epub 2018 Nov 14.

Photobiological Dermatology Laboratory, Medical Research Centre, Department of Medicine and Dermatology, Faculty of Medicine, University of Málaga, Málaga, Spain; Department of Dermatology, Virgen de la Victoria Hospital, Málaga, Spain.

UV radiation has been consistently reported to cause folate photodegradation in vitro and in human skin. Seasonal variations in UV radiation might explain seasonal changes in folate levels in blood. Yet, few studies have addressed this phenomenon. Read More

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November 2018
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Spherical mesocrystals from self-assembly of folic acid and nickel(II) ion for high-performance supercapacitors.

J Colloid Interface Sci 2018 Nov 23;538:142-148. Epub 2018 Nov 23.

Ministry of Education Key Laboratory of Advanced Civil Engineering Materials, School of Materials Science and Engineering, and Institute for Advanced Study, Tongji University, Shanghai 201804, China. Electronic address:

The formation of spherical mesocrystalline microparticles (FA-Ni) was achieved through the self-assembly between folic acid and nickel ions. Such favorable structure and the existence of abundant active sites within FA-Ni were responsible for the high specific capacitance (912 F g at 0.5 A g) and energy density (27. Read More

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November 2018

Methotrexate induces astrocyte apoptosis by disrupting folate metabolism in the mouse juvenile central nervous system.

Toxicol Lett 2018 Nov 28;301:146-156. Epub 2018 Nov 28.

Department of Pharmacy, Hangzhou Medical College, Hangzhou 310053, China. Electronic address:

Methotrexate (MTX) is a folic acid antagonist and widely used for acute lymphoblastic leukemia (ALL) in children. MTX is associated with acute and chronic neurotoxicity during treatment, however the underlying mechanism is still poorly understood. In this study we investigate whether MTX is neurovirulent to astrocytes in the Central Nervous System (CNS) of adolescent mice. Read More

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November 2018

DNA Methylation Changes in Whole Blood and CD16+ Neutrophils in Response to Chronic Folic Acid Supplementation in Women of Childbearing Age.

Int J Vitam Nutr Res 2018 Nov 30:1-8. Epub 2018 Nov 30.

1 Department of Foods and Nutrition, University of Georgia, Athens, GA, USA.

Folate, a water-soluble vitamin, is a key source of one-carbon groups for DNA methylation, but studies of the DNA methylation response to supplemental folic acid yield inconsistent results. These studies are commonly conducted using whole blood, which contains a mixed population of white blood cells that have been shown to confound results. The objective of this study was to determine if CD16+ neutrophils may provide more specific data than whole blood for identifying DNA methylation response to chronic folic acid supplementation. Read More

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November 2018

Associations between biochemical components of human semen with seminal conditions.

Syst Biol Reprod Med 2018 Nov 30:1-9. Epub 2018 Nov 30.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

The aim of the study was to assess whether abnormal levels of seminal biochemical components could be associated with semen alterations and infertility. In this study, 92 human ejaculates from selected men were analyzed. Albumin, estradiol, ferritin, total proteins (TP), folic acid (FA), vitamin B12, alkaline phosphatase (ALP), creatine kinase (CK), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase were evaluated. Read More

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November 2018

Effectiveness of programme approaches to improve the coverage of maternal nutrition interventions in South Asia.

Matern Child Nutr 2018 Nov;14 Suppl 4:e12699

Global Technical Services, Nutrition International, Ottawa, Canada.

The nutritional status of women before pregnancy, during pregnancy, and after delivery has far reaching consequences for maternal health and child survival, growth, and development. In South Asia, the high prevalence of short stature, thinness, and anaemia among women of reproductive age underlie the high prevalence of child undernutrition in the region, whereas overweight and obesity are rising concerns. A systematic review of evidence (2000-2017) was conducted to identify barriers and programme approaches to improving the coverage of maternal nutrition interventions in the region. Read More

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November 2018
2 Reads

Epidemiology of anaemia in children, adolescent girls, and women in Bhutan.

Matern Child Nutr 2018 Nov;14 Suppl 4:e12740

Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Anaemia inhibits health and development in Bhutan. We estimated anaemia prevalence and explored risk factors in children and women using data from Bhutan's National Nutrition Survey 2015. Prevalence was calculated using life-stage-specific cut-offs adjusted for altitude and survey design. Read More

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November 2018

Starburst Poly(amidoamine) Dendrimer Grafted Gold Nanoparticles as a Scaffold for Folic Acid-Targeted Plasmid DNA Delivery .

J Nanosci Nanotechnol 2019 Apr;19(4):1959-1970

Non-Viral Gene Delivery Laboratory, Discipline of Biochemistry University of KwaZulu-Natal, School of Life Sciences, Private Bag X54001, Durban 4000, South Africa.

Gene therapy has opened doors for the treatment of genetic disorders such as cancer. However, it clinical application has been limited by safety-efficacy issues. Recently, dendritic stabilized metal nanoparticles have shown great potential as efficient non-viral modalities for plasmid DNA delivery. Read More

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April 2019
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Maternal postpartum plasma folate status and preterm birth in a high-risk US population.

Public Health Nutr 2018 Nov 29:1-11. Epub 2018 Nov 29.

1Department of Population, Family and Reproductive Health, Center on Early Life Origins of Disease,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.

Objective: While maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. Read More

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November 2018
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Maternal periconceptional consumption of sprouted potato and risks of neural tube defects and orofacial clefts.

Nutr J 2018 Nov 28;17(1):112. Epub 2018 Nov 28.

Peking University Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Beijing, 100191, China.

Background: The association between maternal consumption of sprouted potato during periconceptional period on the development of neural tube defects (NTDs) or orofacial clefts (OFCs) remains unclear. We aimed to examine the association between maternal consumption of sprouted potatoes during periconceptional period and risks of NTDs or OFCs.

Methods: Subjects included 622 NTD cases, 135 OFC cases and 858 nonmalformed controls, were recruited from a case-control study in Shanxi Province of northern China between 2002 and 2007. Read More

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November 2018

Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes.

J Agric Food Chem 2018 Nov 28. Epub 2018 Nov 28.

Abdominal fat or fatty liver cause huge economic loss in poultry industry and nonalcoholic fatty liver disease (NAFLD) is also a global health issue in human. More than 90% of de novo lipogenesis in human and chickens is undertaken by the liver which is proved to be full of lipid in new-born chickens. Folic acid was thought to have correlation with lipid metabolism. Read More

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November 2018
2 Reads

Different age-independent effects of nutraceutical combinations on endothelium-mediated coronary flow reserve.

Immun Ageing 2018 22;15:30. Epub 2018 Nov 22.

1Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy.

Background: Some components of Nutraceuticals (NUT) such as red yeast rice and have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of two different NUT combinations on cold pressure test (CPT) derived coronary flow reserve (CFR) assessed by transthoracic echo-Doppler.

Results: In a randomized, single-blind study, 28 consecutive patients with a variety of cardiovascular risk factors received NUT A (LopiGLIK®: berberine, red yeast rice powder, and leaf extract of ) or B (Armolipid Plus®: policosanol, red yeast rice, berberine, astaxantine, folic acidandcoenzyme Q10). Read More

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November 2018
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Effects of folic acid on growth performance, ruminal fermentation, nutrient digestibility and urinary excretion of purine derivatives in post-weaned dairy calves.

Arch Anim Nutr 2018 Nov 26:1-12. Epub 2018 Nov 26.

b Office of Grass and Feed, Animal Husbandry and Veterinary Bureau of Yuci County , Yuci , Shanxi Province , P.R. China.

This study evaluated the effects of folic acid (FA) supplementation on growth performance, ruminal fermentation, nutrient digestibility and urinary purine derivatives (PD) excretion in dairy calves. Forty-eight Chinese Holstein male dairy calves at 60 ± 3.2 d of age and 89 ± 5. Read More

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November 2018
6 Reads

Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats.

Radiat Environ Biophys 2018 Nov 24. Epub 2018 Nov 24.

Department of Neurosurgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Folic acid (FA) has high affinity for the folate receptor (FR), which is limited expressed in normal human tissues, but over-expressed in several tumor cells, including glioblastoma cells. In the present work, a novel pteroyl-closo-dodecaborate conjugate (PBC) was developed, in which the pteroyl group interacts with FR, and the efficacy of boron neutron capture therapy (BNCT) using PBC was investigated. Thus, in vitro and in vivo studies were performed using F98 rat glioma cells and F98 glioma-bearing rats. Read More

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November 2018
2 Reads

Association of maternal serum copper during early pregnancy with the risk of spontaneous preterm birth: A nested case-control study in China.

Environ Int 2018 Nov 22. Epub 2018 Nov 22.

Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.

Background: The effect of maternal copper (Cu) level on the risk of spontaneous preterm birth (SPB) remains debate. Therefore, we conducted a prospective nested case-control study in Shanxi Province to investigate the relationship between maternal serum Cu concentration and SPB risk, as well as the potential mediation effect of lipid metabolism.

Method: From an overall cohort of 4229 women, 147 women affected by SPB at 20-36 gestational weeks (cases) and 381 women who delivered at ≥37 gestational weeks (controls) were included in our nested case-control study. Read More

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November 2018

Stable mesoporous silica nanoparticles incorporated with MoS2 and AIE for targeted fluorescence imaging and photothermal therapy of cancer cells.

Colloids Surf B Biointerfaces 2018 Nov 15;174:324-332. Epub 2018 Nov 15.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address:

Theranostics for imaging-guided cancer treatment have obtained great attention in recent years for their outstanding capability of both tumor diagnosis and treatment. Molybdenum disulfide (MoS) nanosheets revealed excellent photothermal conversion efficiency, which could be used as photothermal agents. However, MoS nanosheets would often quench or decrease the emission of fluorescence dyes when they were incorporated with these dyes to construct fluorescence-imaging-guided nanotheranostic systems. Read More

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November 2018
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Copper nanoclusters-enhanced chemiluminescence for folic acid and nitrite detection.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 20;210:315-320. Epub 2018 Nov 20.

School of Chemistry and Material Science, Shanxi Normal University, Linfen 041004, Shanxi, PR China.

The reaction between diperiodatoargentate(III) (DPA) and folic acid (FA) produced weak chemiluminescence (CL) in acid medium, which was greatly enhanced in the presence of copper nanoclusters (CuNCs). The CL intensity of CuNCs-DPA-FA system increased with the concentration of FA ranging from 0.1 to 10. Read More

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November 2018

Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys.

J Control Release 2018 Nov 23;293:113-125. Epub 2018 Nov 23.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. Electronic address:

The aim of the present study was to develop folic acid (FA) conjugates which can deliver the kinase inhibitor dactolisib to the kidneys via folate receptor-mediated uptake in tubular epithelial cells. Dactolisib is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) and is considered an attractive agent for treatment of polycystic kidney disease. The ethylenediamine platinum(II) linker, herein called Lx, was employed to couple dactolisib via coordination chemistry to thiol-containing FA-spacer adducts to yield FA-Lx-dactolisib conjugates. Read More

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November 2018
4 Reads

Multi-functional core-shell FeO@Au nanoparticles for cancer diagnosis and therapy.

Colloids Surf B Biointerfaces 2018 Nov 15;174:252-259. Epub 2018 Nov 15.

Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai, 603 103, India. Electronic address:

Multi-functional core-shell FeO@Au nanoparticles (FeO@Au-DOX-mPEG/PEG-FA NPs) conjugated with doxorubicin (DOX), methoxy poly(ethylene glycol) (mPEG), and folic acid-linked poly(ethylene glycol) (PEG-FA) were synthesized for cancer theranostic applications. In the developed NPs, the DOX was chemically conjugated at the surface of core-shell FeO@Au NPs using L-cysteine methyl ester (LCME) as a linker by acid-sensitive hydrazone bond. The formation of FeO@Au-DOX-mPEG/PEG-FA NPs was confirmed by H-NMR analysis. Read More

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November 2018
9 Reads
4.152 Impact Factor

Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.

Acta Paediatr 2018 Nov 22. Epub 2018 Nov 22.

Department of Preventive Medicine and Public Health, Faculty of Medicine and Health Science, Universitat Rovira i Virgili, Reus, Spain.

Aim: The impact of prenatal folic acid on children's neurodevelopment and the risk of autism spectrum disorder (ASD) remain unclear and this review and meta-analysis aimed to quantify any associations.

Methods: We systematically searched PubMed, Scopus and The Cochrane Library until June 2018 with no language restrictions. Standardised mean differences and odds ratio with 95% confidence intervals are used to describe any associations between folic acid and mental development, motor development and ASD. Read More

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November 2018
2 Reads

Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes.

J Photochem Photobiol B 2018 Dec 17;189:318-325. Epub 2018 Sep 17.

Merz Pharmaceuticals GmbH, Alfred-Wegener-Straße 2, 60438 Frankfurt, Germany. Electronic address:

Background: Ultraviolet radiation (UVR) is known to be harmful to normal human epidermal keratinocytes (NHEKs) of the epidermal skin layer, as well as to hair-follicle-associated keratinocytes. An oral formulation containing l-cystine, thiamin, calcium d-pantothenate, medicinal yeast, keratin and p-aminobenzoic acid (Panto[vi]gar®) has demonstrated clinical efficacy for the treatment of diffuse telogen effluvium; however, its mode of action at the cellular level, and in particular whether protective mechanisms are involved, has yet to be elucidated.

Objectives: To assess the capacity of ingredients of this oral formulation, both separately and in combination, to modulate the effects of UVR in growth-limited NHEKs in vitro. Read More

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December 2018
2 Reads

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer.

Drug Deliv 2018 Nov;25(1):1811-1825

a Medical Imaging Center , First Affiliated Hospital of Jinan University , Guangzhou , China.

The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Read More

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November 2018
3 Reads

Ni-hemin metal-organic framework with highly efficient peroxidase catalytic activity: toward colorimetric cancer cell detection and targeted therapeutics.

J Nanobiotechnology 2018 Nov 20;16(1):93. Epub 2018 Nov 20.

Cellular and Molecular Reserch Center, Kurdistan University of Medical Sciences, 66177-13446, Sananandaj, Iran.

Background: Given the great benefits of artificial enzymes, a simple approach is proposed via assembling of Ni with hemin for synthesis of Ni-hemin metal-organic-frameworks (Ni-hemin MOFs) mimic enzyme. The formation of the Ni-hemin MOFs was verified by scanning electron microscopy, Transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Energy-dispersive X-ray spectroscopy and UV-vis absorption spectroscopy. This novel nanocomposite exhibited surprising peroxidase like activity monitored by catalytic oxidation of a typical peroxidase substrate, 3,3,5,5'-tetramethylbenzidine, in the presence of HO. Read More

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November 2018
1 Read

[Folic Acid Intake Among Women in Berlin According to Their Socio-Economic Status].

Z Geburtshilfe Neonatol 2018 Nov 16. Epub 2018 Nov 16.

Gynäkologie, Vivantes Auguste Viktoria Klinikum, Berlin.

Introduction: The intake of folic acid before and during pregnancy is known to reduce the risk of neural tube defects. Many pregnant women do take folic acid at some point during their pregnancy. Very few of them start taking supplements before conception as recommended. Read More

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November 2018

The role of ultrasonography in methotrexate therapy for ectopic pregnancy.

Authors:
Piotr Czuczwar

J Ultrason 2018 ;18(73):158-161

3rd Department of Gynecology, Medical University of Lublin, Lublin, Poland.

Medical management of ectopic pregnancy with methotrexate, an antimetabolite of folic acid, is an important alternative to surgical treatment, as it ensures a similar outcome whilst being far less invasive. Ultrasound evaluation does not only facilitate an accurate diagnosis, but also helps to select patients most likely to benefit from methotrexate treatment, as opposed to those with a high likelihood of failure of medical management, who are thus eligible for primary surgical treatment. Ultrasound also allows to monitor the outcome of methotrexate therapy. Read More

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January 2018
4 Reads

Label Free Ultrasmall Fluoromagnetic Ferrite-clusters for Targeted Cancer Imaging and Drug Delivery.

Curr Drug Deliv 2018 Nov 18. Epub 2018 Nov 18.

Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research & Education (CARE), Kelambakkam, Chennai 603 103. India.

The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and magnetic resonance (MR) cancer imaging. The ultra-small manganese ferrite nanoclusters (PMNCs) with a diameter of 4 nm has commendable effect on the longitudinal (T1) and transverse (T2) relaxation in MR imaging that was evident from the phantom and animal MRI. The calculated longitudinal molar relaxivity of nanoclusters was found to be 6. Read More

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November 2018
3 Reads

Targeting MTHFR for the treatment of migraines.

Expert Opin Ther Targets 2018 Nov 17:1-9. Epub 2018 Nov 17.

a Headache Center, Department of Neuroscience "Rita Levi Montalcini" , University of Torino , Torino , Italy.

Introduction: Migraine is a common neurovascular disorder classified by the World Health Organization as one of the most debilitating diseases. Migraine is a complex disease and is a consequence of an interaction between genetic, epigenetic and environmental factors. The MTHFR gene is one of the few replicated genetic risk factors for migraine and encodes an enzyme that is crucial for the folate and the methionine cycles. Read More

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November 2018
4 Reads

Multiplexed In Vivo Imaging Using Size-Controlled Quantum Dots in the Second Near-Infrared Window.

Adv Healthc Mater 2018 Nov 19:e1800695. Epub 2018 Nov 19.

Department of Chemistry, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

PbS/CdS core/shell quantum dots (QDs) that emit at the second near-infrared (NIR-II, 1000-1700 nm) window are synthesized. The PbS seed size and CdS shell thicknesses are carefully controlled to produce bright and narrow fluorescence that are suitable for multiplexing. A polymer encapsulation yields polymer-encapsulated NIR-II QDs (PQDs), which provides the QDs with long-term fluorescence stability over a week in biological media. Read More

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November 2018
6 Reads

Preparation and characterization of folic acid functionalized bioactive glass for targeted delivery and sustained release of methotrexate.

J Biomed Mater Res A 2018 Nov 18. Epub 2018 Nov 18.

Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou, South China University of Technology, Guangdong, China.

We have successfully prepared a novel targeted drug delivery system, composed of folic acid (FA) as targeting molecule, methotrexate (MTX) as anticancer drug, and bioactive glass (BG) as carrier. The BG nanoparticles were synthesized by sol-gel method with the dodecylamine as template. The surface of BG nanoparticles was grafted with amino groups by (3-aminopropyl) triethoxysilane, then, FA and MTX were covalently conjugated to the surface of modified BG through amidation reaction, so FA functionalized BG (BG-FA) and targeted drug delivery system (MTX-BG-FA) were prepared. Read More

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November 2018
1 Read

A descriptive study of clinico-hematological profile of megaloblastic anemia in a tertiary care hospital.

Med J Armed Forces India 2018 Oct 27;74(4):365-370. Epub 2017 Dec 27.

Brig Med, HQ 12 Corps, C/o 56 APO, India.

Background: Megaloblastic Anemia (MA) is a relatively common disease, yet the data on prevalence of MA remains scarce. This study was conducted to study the prevalence and clinico-hematological profile of MA.

Methods: This was a cross-sectional study done on 1150 adult anemic patients. Read More

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October 2018
6 Reads

Development and characterization of folic acid-functionalized apoferritin as a delivery vehicle for epirubicin against MCF-7 breast cancer cells.

Artif Cells Nanomed Biotechnol 2018 Nov 19:1-8. Epub 2018 Nov 19.

g Medical Biology Research Center, Kermanshah University of Medical Sciences , Kermanshah , Iran.

Epirubicin (Epr) is an effective chemotherapeutic drug; however, the clinical amenability of Epr is limited by its highly toxic interaction with normal cells. This toxicity can be decreased by utilizing nanocarriers and targeted drug delivery systems. This work describes an approach for the delivery of Epr via encapsulation in the horse spleen apoferritin (HsAFr) cavity. Read More

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November 2018
2 Reads

Smoking cessation support and obstetric outcomes in an Irish maternity hospital.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 12;232:1-4. Epub 2018 Nov 12.

Coombe Women and Infants University Hospital, Cork Street, Dublin 8, Ireland; Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

Objective: Maternal cigarette smoking is a recognised risk factor for maternal and fetal morbidity and mortality and remains a significant problem in the Irish maternity system. Approximately 11% of Irish women will continue to smoke in pregnancy, despite awareness of the negative impact on their pregnancy. Although recommendations exist for the management of pregnant smokers, information on the antenatal care of Irish smokers in pregnancy has not been described. Read More

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November 2018
5 Reads

Maternal folic acid deficiency stimulates neural cell apoptosis via miR-34a associated with Bcl-2 in the rat foetal brain.

Int J Dev Neurosci 2018 Nov 14;72:6-12. Epub 2018 Nov 14.

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development. Read More

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November 2018
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Prenatal iron containing supplements provided to Chinese women with no or mild anemia had no effect on hemoglobin concentration in post-partum women or their infants at 6 and 12 months of age.

Eur J Clin Nutr 2018 Nov 16. Epub 2018 Nov 16.

Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.

Background: Although prenatal iron-containing supplements have been associated with lower anemia prevalence in later pregnancy, few trials have examined the effect of supplements on the anemia status of post-partum women and their infants.

Objective: We compared the effects of folic acid alone (FA), iron-folic acid (IFA) and multiple micronutrients (MMN) when provided to pregnant women with no or mild anemia on the hemoglobin levels of post-partum women and their infants at 6 and 12 months of age. We also examined the potential modifying effect of maternal hemoglobin concentration at enrollment. Read More

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November 2018
6 Reads

Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management.

J Formos Med Assoc 2018 Nov 14. Epub 2018 Nov 14.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAS, namely minor, major, and herpetiform types, can be identified. RAS more commonly affects labial mucosa, buccal mucosa, and tongue. Read More

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November 2018
3 Reads

Consumption habits of pregnant women in the Jazan region, Saudi Arabia: a descriptive study.

BMC Res Notes 2018 Nov 16;11(1):817. Epub 2018 Nov 16.

Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Objective: Maternal nutritional habits are critical for the health of both mother and offspring. Postpartum outcomes for mother and infant are strongly influenced by the mother's nutritional status. Information about consumption habits among pregnant women in Saudi Arabia is scarce. Read More

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November 2018
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Enhanced anti-tumor efficacy and reduced cardiotoxicity of doxorubicin delivered in a novel plant virus nanoparticle.

Colloids Surf B Biointerfaces 2018 Nov 6;174:80-86. Epub 2018 Nov 6.

Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Plant viruses are one of the newly applied nanoparticles as drug delivery vehicles. Here, we investigated drug delivery performance of Johnson grass chlorotic stripe mosaic virus (JgCSMV) conjugated to folic acid (FA) for targeted delivery of doxorubicin (Dox). The FA-JgCSMV-Dox complex was synthesized and characterized using spectrophotometry, native and denaturing gel electrophoresis and transmission electron microscopy, which disclosed that JgCSMV virions encapsulated Dox and showed comparable size and morphology to the native particles. Read More

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November 2018
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Effect of the Folate Ligand Density on the Targeting Property of Folated-Conjugated Polymeric Nanoparticles.

Macromol Biosci 2018 Nov 16:e1800348. Epub 2018 Nov 16.

School of Life Science, Jiangxi Science and Technology Normal University, Nanchang, 330013, China.

Targeted drug delivery systems have attracted increasing attention due to their ability for delivering anticancer drugs selectively to tumor cells. Folic acid (FA)-conjugated targeted block copolymers, FA-Pluronic-polycaprolactone (FA-Pluronic-PCL) are synthesized in this study. The anticancer drug paclitaxel (PTX) is loaded in FA-Pluronic-PCL nanoparticles by nanoprecipitation method. Read More

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November 2018
3 Reads