9,114 results match your criteria Folic Acid Deficiency


Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease.

Front Nutr 2021 21;8:642306. Epub 2021 Apr 21.

Food, Nutrition, and Health, The University of British Columbia, Vancouver, BC, Canada.

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a variant (rs344) in the gene encoding the β-globin subunit of hemoglobin. Chronic hemolytic anemia and increased erythropoiesis and RBC turnover in individuals with SCD can result in increased needs for folate and other B-vitamins. We assessed B-vitamin status, and the distribution of folate forms, including unmetabolized folic acid (UMFA), in Canadian children with SCD supplemented with 1 mg/d folic acid (current routine practice). Read More

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Hyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment.

Metabolomics 2021 May 9;17(5):47. Epub 2021 May 9.

Cardiovascular Diseases & Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, 695014, India.

Introduction: Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated with any serum metabolites. Read More

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Gestational folic acid deficiency alters embryonic eye development: Possible role of basement membrane proteins in eye malformations.

Nutrition 2021 Mar 26;90:111250. Epub 2021 Mar 26.

Universidad Complutense de Madrid, Faculty of Optics and Optometry, Anatomy and Embryology Department, Madrid, Spain; Universidad Complutense de Madrid, Faculty of Medicine, Anatomy and Embryology Department, Madrid, Spain.

Objectives: Folic acid (FA) is crucial before and during early pregnancy. FA deficiency can occur because dietary FA intake is low in mothers at the time of conception. Likewise, various ocular pathologies are related to the alteration of extracellular matrices. Read More

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A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.

Sci Rep 2021 May 6;11(1):9646. Epub 2021 May 6.

Center for Food Science and Nutrition, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Adequate micronutrient status during adolescence can break the inter-generational cycle of malnutrition. This study evaluated the effect of community-based weekly iron-folic acid supplementation (WIFAS) on serum ferritin (SF), serum folate (SFol) and hemoglobin concentration (Hb) among adolescent girls. A community-based, individually randomized-controlled trial (RCT) was conducted in four villages of Wolaita and Hadiya zones. Read More

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Improving Micronutrient Status of Children and Women in Rural Communities in India Using Crystal Salt Enriched with Multiple Micronutrients.

J Nutr Sci Vitaminol (Tokyo) 2021 ;67(2):111-117

VitMin lab.

To demonstrate that fortified crystal salt enriched with iron, iodine, vitamin B12, folic acid and zinc can combat multi-micronutrient deficiencies. A randomized controlled study was conducted in 6 villages in Tiruvallur district, in Tamilnadu, South India. All the women and children aged 5-17 y in households in the experimental villages (n=117) were provided the fortified salt for 8 mo. Read More

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January 2021

Vitamins in Human and Donkey Milk: Functional and Nutritional Role.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

School of Pharmacy, University of Camerino, 62032 Camerino, Italy.

Background: Whole milk is a good source of all the nutrients, and it also contains a sufficient number of vitamins to permit regular the growth of the neonate. Dairy cow milk can create allergy in infants less than 12 months old because of the high caseins and β-lactoglobulin content. In these circumstances, donkey milk can represent a good replacement for dairy cows' milk in children affected by Cow Milk Protein Allergy (CMPA) because of its close chemical composition with human milk, mainly due to its low protein and low mineral content. Read More

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Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.

Front Endocrinol (Lausanne) 2021 12;12:619176. Epub 2021 Apr 12.

Diabetes Unit, KEM Hospital Research Center, Pune, India.

Background: Vitamins B12 and folate participate in the one-carbon metabolism cycle and hence regulate fetal growth. Though vitamin B12 deficiency is widely prevalent, the current public health policy in India is to supplement only iron and folic acid for the prevention of anaemia. Prompted by our research findings of the importance of maternal vitamin B12 status for a healthy pregnancy, birth and offspring health outcomes, we evaluated available literature evidence using a systematic review approach, to inform policy. Read More

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Perceptions of women, their husbands and healthcare providers about anemia in rural Pakistan: Findings from a qualitative exploratory study.

PLoS One 2021 27;16(4):e0249360. Epub 2021 Apr 27.

Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.

Background: In Pakistan, there is a dearth of literature on the perceptions of anemia among women of reproductive age (WRA). This study was undertaken to explore the perceptions of women, their husbands, and healthcare providers about anemia, its possible causes, and how anemia impacts maternal and child health in Thatta, Pakistan.

Methods: A qualitative study was conducted in Thatta, Pakistan from September to December 2018. Read More

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Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats.

Front Nutr 2021 7;8:654624. Epub 2021 Apr 7.

Department of Dairy Technology Research, Food Technology Research Institute, Agriculture Research Center, Giza, Egypt.

Iron deficiency anemia (IDA) is a major health concern in developing countries, and these see an increased incidence in pregnant women and children in particular. The contribution of dairy products as natural products in drug delivery approaches is inspiring. This study aimed to analyze the application of iron (Fe) and folic acid (FA) bovine serum albumin-nanoparticles (BSA-NPs) as anti-anemic pharmacological agents that fortify stirred functional yogurt (SFY), comparing these with a plain control and SFY fortified with Fe and FA in free forms. Read More

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The effects of folate and iron deficiency followed by supplementation on blood morphology and inflammation biomarkers in rats.

Acta Sci Pol Technol Aliment 2021 Apr-Jun;20(2):213-222

Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poland.

Background: Little is known about the relation between iron and folic acid (FA) supplementation and inflammation. The aim of this study was to evaluate the effects of iron and folate deficiency and supplementation on blood morphology parameters, and to assess the role of iron and folate transporters in inflammation.

Methods: A four-week period of FA and iron deficiency in Wistar rats was followed by randomization into a group fed with a diet deficient in FA and supplemented with Fe (DFE), a group fed a diet deficient in Fe and supplemented with FA (DFOL), a group fed a diet supplemented with Fe and FA (FEFOL), a group fed a diet deficient in Fe and FA (D), and a group fed a control diet (C). Read More

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The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial.

Acta Obstet Gynecol Scand 2021 Apr 21. Epub 2021 Apr 21.

Institute of Medicine, Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Introduction: Iron deficiency during pregnancy is a global health problem and is associated with adverse pregnancy outcomes. The aim of this randomized, double-blind, placebo-controlled study was to evaluate the effect of Lactiplantibacillus plantarum 299v (Lp299v, 10 colony forming units), 4.2 mg iron, 12 mg ascorbic acid and 30 µg folic acid (Lp) on iron status in healthy, non-anemic, pregnant Swedish women. Read More

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Iron and Folic Acid Supplementation Compliance and Associated Factors among Pregnant Women Attending Antenatal Clinic in Shalla District, Southwest Ethiopia: A Cross-Sectional Study.

J Nutr Metab 2021 27;2021:6655027. Epub 2021 Mar 27.

Hawassa University College of Medicine and Health Science, Hawassa, Ethiopia.

Background: Iron-folate supplementation for a pregnant mother is a cost-effective intervention to reduce iron deficiency anemia during pregnancy. The aim of this study was to assess the iron-folic acid supplements and associated factors among pregnant women attending antenatal clinics in the public health center of Shalla district, Southwest Ethiopia.

Methods: Institutional-based cross-sectional study design was conducted among 402 randomly selected pregnant mothers between February and April 2019. Read More

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[Which is the role of the oral iron therapies for iron deficiency anemia in non-dialysis-dependent chronic kidney disease patients? Results from clinical experience].

G Ital Nefrol 2021 Apr 14;38(2). Epub 2021 Apr 14.

Struttura Complessa di Nefrologia e Dialisi, Fondazione "Casa Sollievo della Sofferenza", IRCCS, San Giovanni Rotondo (FG), Italia.

Iron deficiency afflicts about 60% of dialysis patients and about 30% of non-dialysis-dependent CKD patients (ND-CKD). The role of iron deficiency in determining anemia in CKD patients is so relevant that guidelines from the Kidney Disease Improving Global Outcomes (KDIGO) initiative recommend treating it before starting with erythropoiesis-stimulating agents. KDIGO guidelines suggest oral iron therapy because it is commonly available and inexpensive, although it is often characterized by low bioavailability and low compliance due to adverse effects. Read More

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The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review.

Int J Dev Neurosci 2021 Apr 13. Epub 2021 Apr 13.

Division of Medical Education, Weill Cornell Medicine - Qatar, Doha, Qatar.

Neural tube defects (NTDs) are birth defects that arise during embryogenesis when normal neural tube closure fails to occur. According to the World Health Organization, NTDs are detected annually in approximately 300,000 neonates worldwide. The exact etiology of NTDs remains complex and poorly understood. Read More

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Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum.

Schizophr Res 2021 Apr 7. Epub 2021 Apr 7.

Department of Psychiatry, Division of Maternal and Fetal Medicine, University of Colorado School of Medicine, Anschutz Medical Center, Mail Stop F546, Aurora, CO 80045, USA; Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, University of Colorado School of Medicine, Anschutz Medical Center, Mail Stop F546, Aurora, CO 80045, USA.

Choline, folic acid, and Vitamin D are essential for fetal brain development that may be the first steps in the pathogenesis of the psychotic spectrum. Micronutrient deficiencies have been associated with changes in fetal brain development, manifest as early problems in childhood behavior, and cognition, and later as increased incidence of psychotic and autism spectrum disorders. Micronutrient supplements may not only prevent deficiency, but they may also positively affect brain development in the context of other maternal risk factors, including maternal infection, stress, inflammation, and substance abuse. Read More

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Associations of maternal characteristics and dietary factors with anemia and iron-deficiency in pregnancy.

J Gynecol Obstet Hum Reprod 2021 Apr 7;50(8):102137. Epub 2021 Apr 7.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Ankara University, Ankara, Turkey.

Objective: Anemia and iron deficiency during pregnancy influence maternal and fetal health, birth outcomes, and the risk of chronic disease in offspring. This study aimed to examine the association with sociodemographic, maternal factors, supplement use and dietary intakes, and anemia and iron deficiency in pregnancy.

Methods: A cross-sectional study was conducted on 165 pregnant women aged between 19 and 45 years who were interviewed, and dietary intake was assessed by 24-hours dietary recall, supplement records and food frequency questionnaire. Read More

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[Cobalamin in the complex treatment and prevention of cognitive impairment].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):132-137

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Cognitive impairment (CI) develops not only in structural damage to the central nervous system, but also in encephalopathies of dysmetabolic and deficiency etiology. Recently, special attention is focused on the appearance of CI due to the deficiency of cobalamin (vitamin B) and folic acid (FA), the change in the level of homocysteine (HC). To detect vitamin B deficiency is possible by examining key biomarkers in serum based on a decrease in the levels of vitamin B and holotranscobalamin, and levels of methylmalonic acid (MMA) and HC. Read More

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Impact of daily-supervised administration of a package of iron and folic acid and vitamin B on hemoglobin levels among adolescent girls (12-19 years): a cluster randomized control trial.

Eur J Clin Nutr 2021 Apr 7. Epub 2021 Apr 7.

Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India.

Objective: The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B on hemoglobin levels among adolescent girls.

Methods: A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. Read More

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Assessment of Weekly Iron-Folic Acid Supplementation with and without Health Education on Anemia in Adolescent Girls: A Comparative Study.

Int J Prev Med 2020 30;11:203. Epub 2020 Dec 30.

Department of Community Medicine, SN Medical College, Bagalkot, Karnataka, India.

Background: Iron deficiency is the most common and widespread nutritional disorder in the world, affecting a large number of children and women in developing countries and constituting a public health condition of epidemic proportions. Weekly iron and folic acid supplementation (WIFS) with health education has been demonstrated to be effective in reducing anemia in adolescent school going girls. We assessed the impact of WIFS with and without health education on anemia in adolescent school girls of Delhi. Read More

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December 2020

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.

Nutrients 2021 Mar 12;13(3). Epub 2021 Mar 12.

Institute of Primary Care, University and University Hospital Zurich, 8091 Zurich, Switzerland.

Vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue. In most cases, such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders and the effectiveness of vitamin B12 supplementation in such cases is uncertain. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to assess the effects of vitamin B12 alone (B12 alone), in addition to vitamin B12 and folic acid with or without vitamin B6 (B complex) on cognitive function, depressive symptoms, and idiopathic fatigue in patients without advanced neurological disorders or overt vitamin B12 deficiency. Read More

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Folate Levels in Patients Hospitalized with Coronavirus Disease 2019.

Nutrients 2021 Mar 2;13(3). Epub 2021 Mar 2.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic signifi-cance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Read More

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Prevalence of Micronutrient Deficiency after Bariatric Surgery.

Obes Facts 2021 1;14(2):197-204. Epub 2021 Apr 1.

Department of Medicine I, Hospital Landstrasse, Vienna, Austria.

Introduction: While vitamin deficiency after bariatric surgery has been repeatedly described, few studies have focused on adequate micronutrient status. In this study, we examine the prevalence of vitamin and micronutrient deficiency for the first 3 years after surgery.

Methods: Out of 1,216 patients undergoing surgery, 485 who underwent postoperative follow-up in an outpatient clinic between 2010 and 2019 were included in this evaluation (76. Read More

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Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Exp Ther Med 2021 May 16;21(5):483. Epub 2021 Mar 16.

Department of Cardiology, Tianjin Chest Hospital, Tianjin 300211, P.R. China.

Hyperhomocysteinemia (HHcy) can be used as an independent risk factor for predicting cardiovascular disease, stroke and vitamin B12 deficiency. Patients with HHcy have elevated plasma homocysteine (Hcy) concentrations. Enhancing cerebrovascular permeability of substances such as Hcy and brain damage will synergistically increase the symptoms of hypertension, but the specific immune regulation mechanism is still not clear. Read More

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Effects of maternal folic acid supplementation on nuclear methyltransferase activity of adult rats subjected to an animal model of schizophrenia.

Int J Dev Neurosci 2021 Mar 31. Epub 2021 Mar 31.

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.

Introduction: Schizophrenia is considered one of the most disabling and severe human diseases worldwide. The etiology of schizophrenia is thought to be multifactorial and evidence suggests that DNA methylation can play an important role in underlying pivotal neurobiological alterations of this disorder. Some studies have demonstrated the effects of dietary supplementation as an alternative approach to the prevention of schizophrenia, including folic acid. Read More

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The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease.

J Obstet Gynaecol Res 2021 Mar 29. Epub 2021 Mar 29.

Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Due to the spread of the western style diet, which is characterized by high intake of processed food, micronutrients (vitamins and minerals) deficiency is increasing in the Japanese population of all ages and genders. During pregnancy, the elevated demand for micronutrients put pregnant women at even higher risk of micronutrients deficiency. Some micronutrients are relatively famous such that women with reproductive age are recommended to take folic acid supplementation for the prevention of neural tube defect. Read More

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A review of the maternal iron and folic acid supplementation programme in Nepal: Achievements and challenges.

Matern Child Nutr 2021 Mar 24:e13173. Epub 2021 Mar 24.

Nutrition Section, United Nations Children's Fund (UNICEF), Regional Office for South Asia, Kathmandu, Nepal.

In the late 1990s, an estimated 75% of pregnant women in Nepal were anaemic. Although iron and folic acid (IFA) supplements were available free of charge, coverage among pregnant women was very low. In response, the Government of Nepal launched the Iron Intensification Programme (IIP) in 2003 to improve the coverage of IFA supplementation and anthelminthic treatment during pregnancy, as well as promote the utilization of antenatal care. Read More

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Nutrient supplementation among pregnant women in China: an observational study.

Public Health Nutr 2021 Mar 22:1-19. Epub 2021 Mar 22.

School of Public Health, Shanghai Jiao Tong University, Shanghai200025, China;

Objective: To clarify nutrient supplementation usage and primary source of information among pregnant women in China.

Design: This cross-sectional study used information on nutrient supplementation and primary source of information collected via face-to-face interviews. Data on the usage of folic acid, calcium/vitamin D, iron, vitamins, docosahexaenoic acid, and other dietary supplements were collected. Read More

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Maternal vitamin deficiency mimicking multiple acyl-CoA dehydrogenase deficiency on newborn screening.

Mol Genet Metab Rep 2021 Jun 6;27:100738. Epub 2021 Mar 6.

University Medical Center Mainz, Villa Metabolica, Department of Pediatric and Adolescent Medicine, Mainz, Germany.

Background: In infancy multiple acyl-CoA dehydrogenase deficiency (MADD) is commonly a severe inherited metabolic disease caused by genetic defects in electron transfer flavoprotein (ETF) or ETF ubiquinone oxidoreductase. Both enzymes require flavin adenine dinucleotide (FAD) as a cofactor. Riboflavin (vitamin B) is a precursor in the synthesis of FAD. Read More

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The role of B vitamins in stroke prevention.

Crit Rev Food Sci Nutr 2021 Mar 16:1-14. Epub 2021 Mar 16.

Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.

Elevated plasma levels of homocysteine (Hcy) are a recognized risk factor for stroke. This relationship represents one aspect of the debated `Hcy hypothesis'. Elevated Hcy may be an independent and treatable cause of atherosclerosis and thrombotic vascular diseases. Read More

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