Genes Immun 2009 Sep 7;10(6):547-58. Epub 2009 May 7.
Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, 81531-990 Curitiba, Parana, Brazil.
Following the candidate gene approach we analyzed the CD40L, CD40, BLYS and CD19 genes that participate of B-cell co-stimulation, for association with pemphigus foliaceus (PF), an organ-specific autoimmune disease, characterized by the detachment of epidermal cells from each other (acantholysis) and presence of autoantibodies specific for desmoglein 1 (dsg1), an epidermal cell-adhesion molecule. The disease is endemic in certain regions of Brazil and also is known as fogo selvagem. Complex interactions among environmental and genetic susceptibility factors contribute to the manifestation of this multifactorial disease. Read More