2,117 results match your criteria Focal Status Epilepticus


Corticotropin releasing factor mediates K3.1 inhibition, hyperexcitability and seizures in acquired epilepsy.

J Neurosci 2022 Jun 21. Epub 2022 Jun 21.

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

Temporal lobe epilepsy (TLE), the most common focal seizure disorder in adults, can be instigated in experimental animals by convulsant-induced status epilepticus (SE). Principal hippocampal neurons from SE-experienced epileptic male rats (post-SE neurons) display markedly augmented spike output compared to neurons from nonepileptic animals (non-SE neurons). This enhanced firing results from a c-AMP-dependent protein kinase A (PKA)-mediated inhibition of K3. Read More

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Impact of Genetic Testing on Therapeutic Decision-Making in Childhood-Onset Epilepsies-a Study in a Tertiary Epilepsy Center.

Neurotherapeutics 2022 Jun 20. Epub 2022 Jun 20.

Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Center, Filadelfia, Dianalund, Denmark.

We assessed the frequency of pediatric monogenic epilepsies and precision therapies at a tertiary epilepsy center. We analyzed medical records of children, born in 2006-2011 and followed at the Danish Epilepsy Center from January to December 2015; 357 patients were identified, of whom 27 without epilepsy and 35 with acquired brain damage were excluded. Of the remaining 295 children, 188 were consented for study inclusion and genetic testing. Read More

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Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.

J Chem Neuroanat 2022 Jun 16:102121. Epub 2022 Jun 16.

Neurophysiology Research Center, Shahed University, Tehran, Iran.

Temporal lobe epilepsy (TLE) is presented the most common form of focal epilepsy with involvement of oxidative stress and neuroinflammation as important factors in its development. About one third of epileptic patients are intractable to currently available medications. Paeonol isolated from some herbs with traditional and medicinal uses has shown anti-oxidative and anti-inflammatory effects in different models of neurological disorders. Read More

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Bilateral optogenetic activation of inhibitory cells favors ictogenesis.

Neurobiol Dis 2022 Jun 17;171:105794. Epub 2022 Jun 17.

Montreal Neurological Institute-Hospital and Departments of Neurology & Neurosurgery, and of Physiology, McGill University, 3801 University Street, Montréal, H3A 2B4, QC, Canada. Electronic address:

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal refractory epilepsy and is characterized by recurring seizures that are often refractory to medication. Since parvalbumin-positive (PV) interneurons were recently shown to play significant roles in ictogenesis, we established here how bilateral optogenetic stimulation of these interneurons in the hippocampus CA3 regions modulates seizures, interictal spikes and high-frequency oscillations (HFOs; ripples: 80-200 Hz, fast ripples: 250-500 Hz) in the pilocarpine model of MTLE. Bilateral optogenetic stimulation of CA3 PV-positive interneurons at 8 Hz (lasting 30 s, every 2 min) was implemented in PV-ChR2 mice for 8 consecutive days starting on day 7 (n = 8) or on day 13 (n = 6) after pilocarpine-induced status epilepticus (SE). Read More

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An Investigation into the Correlation of Scalp Electrophysiological Findings with Preoperative Clinical and Imaging Findings in Patients with Focal Cortical Dysplasia.

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Istanbul University, Istanbul Faculty of Medicine, Departments of Neurology and Clinical Neurophysiology, Istanbul, Turkey.

Aim: In this study, patients who had epilepsy surgery and pathologically proven focal cortical dysplasia (FCD) were retrospectively evaluated to classify and discuss electroencephalography (EEG) findings in different pathological subtypes.

Material And Methods: This study included 19 refractory epilepsy patients who underwent surgery between 1999 and 2017 in the Istanbul Faculty of Medicine. Demographic data, preoperative examinations, scalp video EEGs, and postoperative outcomes were evaluated retrospectively. Read More

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December 2021

Predictive Factors of Acute Symptomatic Seizures in Patients With Ischemic Stroke Due to Large Vessel Occlusion.

Front Neurol 2022 27;13:894173. Epub 2022 May 27.

Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.

Introduction: Acute symptomatic seizures (ASz) after ischemic stroke are associated with increased mortality; therefore, identifying predictors of ASz is important. The purpose of this study was to analyze predictors of ASz in a population of patients with ischemic stroke due to large arterial vessel occlusion (LVO).

Materials And Methods: This retrospective study examined patients with acute ischemic stroke caused by LVO between 2016 and 2020. Read More

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Cerebral Hemangiopericytoma Manifesting as Epilepsia Partialis Continua: A Case Report.

JNMA J Nepal Med Assoc 2022 Jun 1;60(250):551-554. Epub 2022 Jun 1.

Department of Neurosurgery, Nepal Medical College and Teaching Hospital, Attarkhel, Kathmandu, Nepal.

Cerebral hemangiopericytomas are very rare mesenchymal tumours arising from pericytes surrounding the blood vessels in the brain. Most patients present with headaches, focal neurological findings and focal seizures with or without generalisation. Our patient chiefly complained of an uncontrollable movement of her right hand that was initially fleeting but later became continuous. Read More

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Isolated aphasic status epilepticus: CT perfusion, SPECT and EEG reveal neurovascular coupling and support the differential diagnosis.

Epileptic Disord 2022 Jun;24(3):1-6

Objective Among the clinical manifestations of stroke mimics, isolated aphasia is one of the most challenging due to its aetiopathogenic diagnosis. This short communication describes a specific perfusion and brain oscillatory pattern in a challenging case of prolonged isolated aphasia caused by status epilepticus, jointly investigated by computed tomography (CT) perfusion, single-photon emission computerized tomography (SPECT)/CT and EEG qualitative and quantitative analysis. Methods We discuss the different patterns of perfusion neuroimaging and EEG between SE and ischaemic stroke or postictal (Todd's)-related isolated aphasia, and propose these differences as a basis to support the differential diagnosis. Read More

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Typical absence status epilepticus in older people: syndromic delineation.

Epileptic Disord 2022 Jun;24(3):1-6

Objective We describe the clinical, electroencephalograph^ and neuroimaging findings of older patients with typical absence status epilepticus (ASE). Methods This investigation was a retrospective analysis of prospectively collected consecutive patients between January 2011 and October 2021. All patients ≥60 years with impairment of awareness and continuous generalized, rhythmic, synchronous and symmetric epileptiform discharges and normal background on video-electroencephalogram (vEEG) were included. Read More

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Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease.

Epilepsia 2022 Jun 2. Epub 2022 Jun 2.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Seizure is one of the manifestations of central nervous system (CNS) inflammatory demyelinating diseases, which mainly include multiple sclerosis (MS), aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). "Acute symptomatic seizures secondary to MS / AQP4-NMOSD / MOGAD" occur in the acute phase of the diseases, and are more frequent in MOGAD. In contrast, recurrent non-provoked seizures, mainly attributed to "autoimmune-associated epilepsy", occur in the non-acute phase of the diseases. Read More

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Rare pitfall in the magnetic resonance imaging of status epilepticus.

eNeurologicalSci 2022 Jun 21;27:100405. Epub 2022 May 21.

Department of Neurology, University of Toledo, Toledo, OH, USA.

Brain MRI in Status Epilepticus (SE) is often helpful in diagnosis, lateralization and localization of the seizure focus. MRI changes in SE include predominantly ipsilateral diffusion weighted imaging (DWI) changes in the hippocampus and pulvinar or similar changes involving basal ganglia, thalamus, cerebellum, brain stem and external capsule (Chatzikonstantinou et al., 2011 [1]). Read More

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Risk factors and a predictive model for the development of epilepsy after Japanese encephalitis.

Seizure 2022 Jul 20;99:105-112. Epub 2022 May 20.

Department of Neurology, Children's Hospital of Chongqing Medical University, China; Ministry of Education Key Laboratory of Child Development and Disorders, China; National Clinical Research Center for Child Health and Disorders (Chongqing) China; China International Science and Technology Cooperation base of Child development and Critical Disorders China; Chongqing Key Laboratory of Pediatrics China. Electronic address:

Background: We aimed to study seizure characteristics during the acute phase of Japanese encephalitis (JE) in children, determine the risk factors of postencephalitic epilepsy (PEE), establish a risk prediction model for the disease, and construct a nomogram to visualize the model.

Methods: We retrospectively analyzed the clinical data and follow-up results of 328 children with JE who were hospitalized between January 2011 and December 2020. Risk factors were screened using univariable analysis, a predictive model was built using binary logistic analysis, lasso regression was used for variable screening, and a nomogram was developed. Read More

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Wernicke Encephalopathy Mimicking MELAS.

Authors:
Josef Finsterer

Medicina (Kaunas) 2022 May 13;58(5). Epub 2022 May 13.

Neurology & Neurophysiology Center, Postfach 20, 1180 Vienna, Austria.

Objectives: a stroke-like lesion, the morphological equivalent of a stroke-like episode and the hallmark of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, have not been reported as manifestations of thiamine deficiency.

Case Report: a 62-year-old man with a history of chronic alcoholism was admitted after a series of epileptic seizures. Upon waking up from the coma, he presented with disorientation, confusion, confabulation, psychomotor agitation, aggressiveness, right hemianopsia, aphasia, and right hemineglect over weeks. Read More

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Epileptic encephalopathy with electrical status epilepticus during slow sleep: evaluation of treatment response from a tertiary center.

Turk J Pediatr 2022 ;64(2):302-311

Department of Pediatric Neurology, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey.

Background: This study aimed to evaluate the clinical, electrophysiological, etiological features, and treatment response in children with epileptic encephalopathy with electrical status epilepticus during slow sleep (ESES).

Methods: Clinical data, records of electroencephalograms (EEG), and brain magnetic resonance imaging (MRI) findings of 33 patients with ESES who were treated, and followed up for at least one year were retrospectively analyzed.

Results: Of all patients, 57. Read More

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Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies.

J Neurol 2022 May 20. Epub 2022 May 20.

Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France.

Objective: To characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic encephalitis, including factors associated with drug-resistant epilepsy (DRE).

Methods: Retrospective analysis of patients with LGI1 encephalitis managed at two tertiary epilepsy centers between 2005 and 2019 and whose samples were confirmed by the French Reference Center of Paraneoplastic Neurological Syndromes. Raw clinical, biological, EEG, and MRI data were reviewed. Read More

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The importance of timing in epilepsia partialis continua.

Neurologia (Engl Ed) 2022 May 6;37(4):263-270. Epub 2021 Apr 6.

Unidad de Epilepsia, Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Introduction: Timing is one of the most important modifiable prognostic factors in the management of status epilepticus. Epilepsia partialis continua (EPC) is a status epilepticus subtype of highly variable, occasionally prolonged, duration. The aim of this study was to analyse the relationship between EPC duration and outcomes. Read More

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Seizures and COVID-19: Results from the Spanish Society of Neurology's COVID-19 registry.

J Clin Neurosci 2022 Jul 16;101:112-117. Epub 2022 May 16.

Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, c/ Diego de Velázquez, 1, 28223 Pozuelo de Alarcón, Madrid, Spain.

We describea series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology's COVID-19 Registry. This observational, descriptive,multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection.Wedescribe theclinicalpresentation of COVID-19,seizures,and resultsof complementary tests. Read More

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Provoked seizures and status epilepticus in a pediatric population with COVID-19 disease.

Epilepsia 2022 May 9. Epub 2022 May 9.

Departments of Neurology and Pediatrics, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.

We are reporting 16 pediatric patients (ages 0-18-years-old) who presented to our urban hospital emergency room with seizures and coronavirus disease 2019 (COVID-19) during the surge of the Omicron variant. There was an increased number of pediatric patients with seizures and COVID-19 during this period as compared to prior COVID-19 surges. The 16 patients ranged in age from 3 months to 12 years of age. Read More

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Landscape of childhood epilepsies - A multi-ethnic population-based study.

Epilepsy Res 2022 Jul 28;183:106936. Epub 2022 Apr 28.

Sidra Medicine, Department of Pediatrics, Division of Pediatric Neurology, Doha, Qatar.

Objective: To describe the clinical features of childhood epilepsy in Qatar.

Methods: A retrospective cross-sectional chart review analysis was conducted at the only tertiary pediatric hospital in Qatar in 1422 patients with epilepsy followed between November 2016 and October 2019.

Results: 55% (781) were males and 70% were non-Qatari. Read More

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Good seizure outcome after focal resection surgery for super-refractory status epilepticus: Report of two cases.

Surg Neurol Int 2022 22;13:164. Epub 2022 Apr 22.

Department of Neurosurgery, Harasanshin Hospital, Fukuoka, Japan.

Background: There is scarce evidence regarding focal resection surgery for super-refractory status epilepticus (SRSE), which is resistant to general anesthetic treatment over 24 h. We report two patients with SRSE, in whom good seizure outcomes were obtained following focal resection surgery.

Case Description: Patient 1: A 58-year-old man who underwent left anterior temporal lobectomy with hippocampectomy at the age of 38 years after being diagnosed left medial temporal lobe epilepsy. Read More

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Rituximab in Rasmussen's encephalitis: A single center experience and review of the literature.

Epilepsy Behav Rep 2022 9;19:100540. Epub 2022 Apr 9.

Department of Radiology, Star Imaging Centre and Research Centre, Pune, India.

Rasmussen's encephalitis (RE) is a rare chronic inflammatory disease of the brain resulting in unilateral hemispheric atrophy with drug-resistant focal epilepsy associated with a variable degree of progressive hemiparesis and cognitive decline. The precise etiology of RE is unknown but presumed to have a neuroinflammatory pathobiological basis. Only surgery halts progression of the disease, but may occur at the expense of a fixed but otherwise inevitable neurological deficit. Read More

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Response of focal refractory status epilepticus to lacosamide in an infant.

BMJ Case Rep 2022 Apr 29;15(4). Epub 2022 Apr 29.

Pediatric Critical Care, University of Illinois College of Medicine at Peoria (UICOMP), Peoria, Illinois, USA.

Status epilepticus (SE) is a life-threatening medical emergency which is frequently encountered in the critical care setting and can be refractory to treatment. Refractory status epilepticus (RSE) is defined as SE that has failed to respond to adequately used first-line and second-line antiepileptic medications. Super refractory status epilepticus is defined as SE that persists for 24 hours or more after the use of an anaesthetic agent or recurs after its withdrawal. Read More

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Single-stage resection of bottom-of-a-sulcus dysplasia involving eloquent cortex using navigated transcranial magnetic stimulation and intraoperative modalities.

Childs Nerv Syst 2022 Apr 21. Epub 2022 Apr 21.

Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Background: Focal cortical dysplasia (FCD) is a common etiology of refractory epilepsy, particularly in children. Surgical management is potentially curative, but poses the challenge of distinguishing the border between ictogenic regions of dysplasia and functionally critical brain tissue. Bottom-of-a-sulcus dysplasia (BOSD) amplifies this challenge, due to difficulties in physiologic mapping of the deep tissue. Read More

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Benefits and Risks of Epilepsy Surgery in Patients With Focal Cortical Dysplasia Type 2 in the Central Region.

Neurology 2022 Apr 13. Epub 2022 Apr 13.

Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences, Paris.

Background: Focal cortical dysplasia type 2 (FCD) in the central region can cause drug-resistant epilepsy for which surgery remains challenging because of subsequent functional deficits. Advances in imaging and surgical techniques have progressively improved outcome. We aimed to assess the benefits on epilepsy and the functional risks after FCD resections in these highly eloquent areas. Read More

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New-Onset Seizures as an Acute Presentation With Atypical EEG Findings in a Previously Healthy Child With Asymptomatic COVID-19 Infection.

Cureus 2022 Mar 6;14(3):e22899. Epub 2022 Mar 6.

Infectious Diseases, University of Illinois College of Medicine at Peoria, Peoria, USA.

Coronavirus disease 2019 (COVID-19) infection is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This infection usually presents with upper respiratory symptoms; however, it can also present with a wide variety of other multisystem and neurological symptoms, including seizures. There are several proposed mechanisms by which COVID-19 can cause systemic signs of infections, including neurological complications and seizures. Read More

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[Clinical phenotypes and genetic features of epilepsy children with MBD5 gene variants].

Zhonghua Er Ke Za Zhi 2022 Apr;60(4):345-349

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the phenotypes of epilepsy in patients with MBD5 gene variants. A total of 9 epileptic patients, who were treated in the Department of Pediatrics, Peking University First Hospital from July 2016 to September 2021 and detected with MBD5 gene pathogenic variants, were enrolled. The features of clinical manifestations, electroencephalogram (EEG), and neuroimaging were analyzed retrospectively. Read More

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[Analysis of clinical and genetic characteristics of epilepsy associated with chromosome 16p11.2 microdeletion].

Zhonghua Er Ke Za Zhi 2022 Apr;60(4):339-344

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To investigate the clinical and genetic characteristics of epilepsy associated with chromosome 16p11.2 microdeletion. The patients (=10) with 16p11. Read More

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Epilepsia Partialis Continua (EPC) as an Uncommon Initial Presentation of Cerebral Venous Sinus Thrombosis (CVST).

Cureus 2022 Feb 19;14(2):e22394. Epub 2022 Feb 19.

Department of Neurosciences, School of Medical Sciences, Hospital Universiti Sains Malaysia, Kota Bharu, MYS.

Cerebral venous sinus thrombosis (CVST) is a rare type of cerebrovascular disease that affects mainly young to middle-aged adults. The main clinical presentation of CVST includes progressive headache, focal neurological deficit, disturbance of conscious level, and epileptic seizures, which can occur early or late in the disease process. Generalized seizure has been recognised as the most common seizure subtype among patients with CVST and epileptic seizures. Read More

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February 2022

Clinical profile and outcomes of epilepsy surgery in children from a tertiary epilepsy care center in India.

Eur J Paediatr Neurol 2022 May 22;38:13-19. Epub 2022 Mar 22.

Department of Speech Pathology and Language, Deenanath Mangeshkar Hospital, Pune, India.

Introduction: The present study aims to describe epilepsy surgery outcomes in the pediatric population from a tertiary center in India.

Methodology: Children less than 18 years who underwent epilepsy surgery between June 2015 and December 2019 for whom at least a 1-year follow-up was available, were retrospectively evaluated for clinical presentation, radiology, surgical intervention, and seizure outcomes.

Observations: Out of a total of 355 epilepsy surgeries performed, 242 were in the pediatric group (140 males, 80 females). Read More

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