1,725 results match your criteria Focal Status Epilepticus


Asymptomatic carotid acute dissection following focal status epilepticus.

Epilepsy Behav Case Rep 2019 17;11:120-121. Epub 2019 Mar 17.

Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Italy.

•CAD is one of the most important predisposing factors of cerebral ischaemia in young adults.•Focal motor seizures with the involvement of the neck may represent a risk condition of developing CAD•A heightened awareness for CAD should be recommended in patients affected by epilepsy, carotid dopplers may confirm the clinical suspicion in case of significant neck trauma associated with seizures. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460323PMC

Rare Complication of Carotid Stenting: New-Onset Refractory Status Epilepticus: A Study of Five Patients.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):210-212

Department of Neurology, Bombay Hospital and Institute of Medical Sciences, Mumbai, Maharashtra, India.

Introduction: New-onset refractory status epilepticus (NORSE) is uncommon and almost 50% of cases are cryptogenic. We report the rare development of NORSE following carotid artery stenting (CAS), a procedure which is increasingly being used to treat the carotid stenosis.

Materials And Methods: Patients who developed NORSE following CAS for the prevention of stroke over a period of 5 years were analyzed retrospectively. Read More

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http://dx.doi.org/10.4103/aian.AIAN_445_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472247PMC

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Lancet 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Electronic address:

Background: Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus.

Methods: This open-label, randomised clinical trial was undertaken at 30 UK emergency departments at secondary and tertiary care centres. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)30724-XDOI Listing

A case of epilepsia partialis continua of abdominal muscles after brain tumor surgery.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3001-3004

IRCCS "NEUROMED", Pozzilli (IS), Italy.

Epilepsia partialis continua (EPC) is a rare form of focal motor status epilepticus characterized by continuous muscular twitches or jerks involving a limited part of the body, usually facial region and distal limb. Although the cerebrovascular disease is known to be one of the most common causes of this condition, other reported cases with predominant abdominal involvement have different aetiologies, including, tumors, focal cortical dysplasia, and central nervous system infections. No cases of epilepsia partialis continua of the abdominal wall occurred after brain surgery have been previously reported. Read More

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http://www.europeanreview.org/article/17581
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http://dx.doi.org/10.26355/eurrev_201904_17581DOI Listing
April 2019
1 Read

Seizure characteristics, treatment, and outcome in autoimmune synaptic encephalitis: A long-term study.

Epilepsy Behav 2019 Apr 8;94:198-203. Epub 2019 Apr 8.

Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Objectives: The objective of this study was to report seizure characteristics, long-term outcome, and potential factors associated with persistent seizures in patients with autoimmune synaptic encephalitis (ASE).

Method: Clinical data and courses of 52 patients with ASE who presented with seizures at the Department of Neurology of the First Hospital of Jilin University from January 2015 to August 2017 were reviewed. Seizure outcomes were assessed with a median follow-up duration of 30 months (8-40 months). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.038DOI Listing
April 2019
1 Read

Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Cryptogenic temporal lobe epilepsy develops in the absence of identified brain injuries, infections, or structural malformations, and in these cases, an unidentified pre-existing abnormality may initiate febrile seizures, hippocampal sclerosis, and epilepsy. Although a role for GABAergic dysfunction in epilepsy is intuitively obvious, no causal relationship has been established. In this study, hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14723
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http://dx.doi.org/10.1111/epi.14723DOI Listing
April 2019
8 Reads

Subacute Encephalopathy With Seizures in Alcoholics Syndrome: A Subtype of Nonconvulsive Status Epilepticus.

Epilepsy Curr 2019 Mar-Apr;19(2):77-82

4 Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

A recent assessment of the classification of nonconvulsive status epilepticus (NCSE) has incorporated the specific electroencephalographic (EEG) patterns on a syndromic basis. Such a clinical EEG syndromic approach may enable more accurate and expedited diagnosis of particular subtypes of NCSE so as to improve therapy. Herein, we review the characteristics of subacute encephalopathy with seizures in alcoholics syndrome, a subtype of focal NCSE occurring in chronic alcoholism with specific features, including encephalopathy, lateralized periodic discharges on the EEG, chronic microvascular ischemia on neuroimaging studies, and possible recurrence when chronic antiseizure treatment is stopped. Read More

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http://dx.doi.org/10.1177/1535759719835676DOI Listing
April 2019
2 Reads

Focal Status Epilepticus With Unilateral Brain Edema: An Expanding Spectrum.

Pediatr Neurol 2019 Feb 8. Epub 2019 Feb 8.

Pediatric Neurology Division, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.02.002DOI Listing
February 2019
1 Read

Non convulsive status epilepticus in the elderly.

Authors:
Sophie Dupont

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):25-30

Epilepsy Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Rehabilitation Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Centre de recherche de l'Institut du cerveau et de la moelle épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France, Université Paris Sorbonne, France.

Non-convulsive status epilepticus (NCSE) is common in the elderly. It most often corresponds to prolonged focal seizures with impaired contact ("complex partial status epilepticus"). A form of de novo absence status epilepticus, much rarer, can also meet. Read More

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http://dx.doi.org/10.1684/pnv.2019.0782DOI Listing
March 2019
1 Read

Distinctive FDG-PET/CT Findings in Acute Neurological Hospital Care.

Neurohospitalist 2019 Apr 15;9(2):93-99. Epub 2018 Oct 15.

Department of Nuclear Medicine, Municipal Hospital Landshut, Germany.

A compilation of 6 distinctive F-fluorodeoxyglucose positron emission tomography (PET) combined with computed tomography (CT) findings in the acute setting of neurohospital care is presented. In case 1, PET/CT allowed the final diagnosis of circumscribed ischemic infarction by demonstrating a clear pattern of luxury perfusion. In case 2, diagnosis of thalamic abscess was made, whereby PET/CT demonstrated an empty zone. Read More

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http://journals.sagepub.com/doi/10.1177/1941874418805339
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http://dx.doi.org/10.1177/1941874418805339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429674PMC
April 2019
3 Reads

Polyarteritis Nodosa in a Cat with Involvement of the Central and Peripheral Nervous Systems.

J Comp Pathol 2019 Feb 18;167:6-11. Epub 2018 Dec 18.

Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, Italy.

An 18-month-old neutered male domestic shorthair cat was referred with a history of pyrexia, polyuria and polydypsia, and transient episodes of bilateral hindlimb paralysis. Cardiac evaluation revealed severe systemic hypertension and severe concentric hypertrophy of the left ventricle. One month later the cat had a new episode of hindlimb paralysis with recurrent seizures, and died in status epilepticus. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.11.003DOI Listing
February 2019
4 Reads

Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES).

Epilepsy Behav 2019 Mar 18;94:93-99. Epub 2019 Mar 18.

Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA; Children's Hospitals and Clinics of Minnesota, St. Paul, Minnesota, USA.

Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.016DOI Listing
March 2019
1 Read

Perampanel Treatment for Refractory Status Epilepticus in a Neurological Intensive Care Unit.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, 123, Dapi Road, Niaosung District, Kaohsiung, 83301, Taiwan.

Background/objective: Perampanel is a novel anti-epileptic drug (AED) which acts as a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist to reduce glutamate-mediated postsynaptic excitation. Previous animal studies and a few case reports/series have suggested that it may be effective to treat refractory status epilepticus (RSE).

Methods: We retrospectively reviewed 67 consecutive patients with RSE, of whom 22 received perampanel. Read More

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http://dx.doi.org/10.1007/s12028-019-00704-9DOI Listing

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy.

Front Neurol 2019 1;10:166. Epub 2019 Mar 1.

Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.

Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e. Read More

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http://dx.doi.org/10.3389/fneur.2019.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413671PMC
March 2019
1 Read

Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis.

Clin EEG Neurosci 2019 Mar 15:1550059419835705. Epub 2019 Mar 15.

2 Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic fatal encephalitis worldwide and remains a devastating disease despite antiviral therapy. EEG can be an important tool in the diagnosis of HSE, and we propose that it can be used to monitor the progression of the disease in patients with treatment refractory HSE.

Methods: This is a case report of a patient with HSE who was monitored on continuous EEG (CEEG) throughout course of her disease. Read More

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http://dx.doi.org/10.1177/1550059419835705DOI Listing
March 2019
4 Reads

Lateralized periodic discharges in insular status epilepticus: A case report of a periodic EEG pattern associated with ictal manifestation.

Clin Neurophysiol Pract 2019 24;4:27-29. Epub 2019 Jan 24.

Department of Neurology, SS Annunziata Hospital, Chieti, Italy.

Objective: Insular lobe seizures generally represent a misconceived ictal phenomenon characterized by specific neurological signs. Aphasia can be a rare presenting sign associated with insular lobe epilepsy which could be easily mistaken for a manifestation of other acute brain diseases.

Method: We describe an insular status epilepticus (SE) characterized by sudden onset of language disturbance associated with hypersalivation and paraesthesia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2467981X193000
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http://dx.doi.org/10.1016/j.cnp.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395825PMC
January 2019
9 Reads

Treatment delay in status epilepticus - more effective prehospital symptom recognition warranted.

Scand J Trauma Resusc Emerg Med 2019 Mar 7;27(1):28. Epub 2019 Mar 7.

Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of ERN EpiCARE, Kuopio, Finland.

Background: The outcome of status epilepticus (SE) can be improved by facilitating early recognition and treatment with antiepileptic drugs. The purpose of this study was to analyze the treatment delay of SE in a prospectively recruited patient cohort. Improvements to the treatment process are suggested. Read More

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http://dx.doi.org/10.1186/s13049-019-0605-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407251PMC
March 2019
1 Read

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.

Epilepsy Behav Case Rep 2019 7;11:92-95. Epub 2019 Feb 7.

Epilepsy Unit, Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384302PMC
February 2019

Attention disorders in adults with epilepsy. Determinants and therapeutic strategies.

Rev Neurol (Paris) 2019 Mar 28;175(3):135-140. Epub 2019 Feb 28.

Epileptology unit, neurology department, Nancy hospital, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France; UMR 7039, CNRS, université de Lorraine, 54500 Nancy, France; Reference, Center for rare Epilepsies, Nancy hospital, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.

Cognitive consequences in epilepsy are often described in the following domains: verbal memory, language, executive functions, and attention. Attention is involved in all cognitive activities, and attention disorders (AD) are reported in patients with various neurological diseases. This paper proposes to define the concept of AD and its assessment, to consider their determinants in epilepsy and potential therapies (drug or not). Read More

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http://dx.doi.org/10.1016/j.neurol.2019.01.394DOI Listing

Reactive seizures in cats: A retrospective study of 64 cases.

Vet J 2019 Feb 20;244:1-6. Epub 2018 Nov 20.

Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.

Epileptic seizures are a common indication for neurological evaluation. This retrospective study reviewed 789 cats referred for epileptic seizure evaluation to the Department of Small Animal Medicine and Surgery of the University of Veterinary Medicine in Hannover, between 1998 and 2017. The aim of this study was to determine common causes for reactive seizures (RS) in cats. Read More

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http://dx.doi.org/10.1016/j.tvjl.2018.11.009DOI Listing
February 2019
2 Reads

Acute Ischemic Stroke Mimicking Non-Convulsive Status Epilepticus.

J Epilepsy Res 2018 Dec 31;8(2):90-92. Epub 2018 Dec 31.

Department of Neurology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Status epilepticus and stroke are occasionally characterized by indistinguishable symptoms. Diffusion-weighted imaging (DWI) could not only help differentiating seizure from stroke, but also assist in localizing a focus of seizure and reflect resolution of seizure. We report a case of non-convulsive status epilepticus that presented as acute ischemic stroke, mimicking the latter's clinical manifestations. Read More

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http://dx.doi.org/10.14581/jer.18015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374534PMC
December 2018

The Claustrum in Relation to Seizures and Electrical Stimulation.

Front Neuroanat 2019 12;13. Epub 2019 Feb 12.

Department of Neurology, The George Washington University, Washington, DC, United States.

The neural mechanisms of altered consciousness that accompanies most epileptic seizures are not known. We have reported alteration of consciousness resulting from electrical stimulation of the claustrum a depth electrode in a woman with refractory focal epilepsy. Additionally, there are reports that suggest possible claustral involvement in focal epilepsy, including MRI findings of bilaterally increased T2 signal intensity in patients with status epilepticus (SE). Read More

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https://www.frontiersin.org/article/10.3389/fnana.2019.00008
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http://dx.doi.org/10.3389/fnana.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379271PMC
February 2019
9 Reads

Seizures and movement disorders: phenomenology, diagnostic challenges and therapeutic approaches.

J Neurol Neurosurg Psychiatry 2019 Feb 22. Epub 2019 Feb 22.

Neurology, Krembil Brain Institute; Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto, Ontario, Canada

Seizures and movement disorders (MDs) are distinct neurological conditions presenting with abnormal movements. Despite sharing an overlap in phenomenology, these movements have different origins. In order to explore the overlaps and the narrow boundaries between these two conditions, we performed a review of the literature to explore the risk of seizures in MDs. Read More

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http://dx.doi.org/10.1136/jnnp-2018-320039DOI Listing
February 2019
2 Reads

Calcium channel subunit α2δ4 is regulated by early growth response 1 and facilitates epileptogenesis.

J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Section for Translational Epilepsy Research, Dept. of Neuropathology, University of Bonn Medical Center, 53105 Bonn, Germany.

Transient brain insults including status epilepticus (SE) can trigger a period of epileptogenesis during which functional and structural reorganization of neuronal networks occurs resulting in the onset of focal epileptic seizures. In recent years, mechanisms that regulate the dynamic transcription of genes during epileptogenesis and thereby contribute to the development of a hyperexcitable neuronal network have been elucidated. Our own results have shown Early growth response 1 (Egr1) to transiently increase expression of the T-type Voltage-dependent Ca-channel (VDCC) subunit Ca3. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1731-18.2019DOI Listing
February 2019
1 Read

Probable sporadic Creutzfeldt-Jakob disease mimicking focal epilepsy.

Epilepsy Behav Case Rep 2019 26;11:77-80. Epub 2019 Jan 26.

Division of Neurology, Department of Internal Medicine, National Yang-Ming University Hospital, No.169, Siaoshe Rd., Yilan City, Yilan County 26058, Taiwan.

Creutzfeldt-Jakob disease (CJD) presents with seizures as an early symptom in only approximately 3% of cases. These seizures often present as nonconvulsive status epilepticus (NCSE) or epilepsia partialis continua (EPC). Here, we describe a case of probable sporadic CJD (sCJD) in an 83-year-old man whose manifest an unusual presentation of left-hand tonic seizures without evolution to EPC, as well as brain MRI findings interpreted as peri-ictal changes, which led to an initial misdiagnosis of focal epilepsy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369248PMC
January 2019
4 Reads

Cortical inhibitory dysfunction in epilepsia partialis continua: A high frequency oscillation somatosensory evoked potential study.

Clin Neurophysiol 2019 Apr 25;130(4):439-444. Epub 2019 Jan 25.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy. Electronic address:

Objective: The pathophysiology of epilepsia partialis continua (EPC) is still unclear, a thalamo-cortical circuit dysfunction has been hypothesized. The aim of present study is the functional evaluation of the thalamo-cortical network in EPC by means of the study of low- and high-frequency somatosensory evoked potentials (LF-SEP and HF-SEP).

Methods: Median LF-SEP and HF-SEP were recorded in 3 patients with EPC and in 2 patients with rolandic lesions without EPC (non-EPC). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.005DOI Listing
April 2019
2 Reads

Rasmussen syndrome: absence seizures may be induced by oxcarbazepine.

Epileptic Disord 2019 Feb;21(1):108-111

Department of Neurology, Hospital de Pediatría "Prof Dr Juan P Garrahan", Buenos Aires.

A female patient with electroclinical and neuroradiological features compatible with Rasmussen syndrome developed a particular clinical and EEG pattern. As the seizures were refractory to valproate at 750 mg/kg/day, oxcarbazepine (OXC) at 30 mg/kg/day was added. Seizures became more frequent and on neurological examination, no hemiparesis was detected. Read More

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http://dx.doi.org/10.1684/epd.2019.1035DOI Listing
February 2019
4 Reads

Focal visual status epilepticus.

Epileptic Disord 2019 Feb;21(1):102-107

Department for Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

Epileptic visual auras are elementary to complex and sometimes occur as colourful visual phenomena located close to or within the central part of the contralateral hemi-field. They typically last from seconds to a few minutes, which discriminates them from the usually longer-lasting visual auras (5-30 minutes) of patients suffering from migraine. We present an adult patient with occipital lobe epilepsy whose visual aura under epilepsy monitoring lasted for more than 30 minutes with almost no propagation, demonstrating a rare, but remarkable, sustained local epileptic network activity associated with resection of an occipital arterio-venous malformation. Read More

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http://dx.doi.org/10.1684/epd.2019.1034DOI Listing
February 2019
1 Read

A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.

Epileptic Disord 2019 Feb;21(1):112-116

Department of Pediatric Epilepsy, Beaumont Health, Royal Oak, MI 48073.

Dynamin-1-like protein (DNM1L) gene variants have been linked to childhood refractory epilepsy, developmental delay, encephalopathy, microcephaly, and progressive diffuse cerebral atrophy. However, only a few cases have been reported in the literature and there is still a limited amount of information about the symptomatology and pathophysiology associated with pathogenic variants of DNM1L. We report a 10-year-old girl with a one-year history of mild learning disorder and absence seizures who presented with new-onset focal status epilepticus which progressed to severe encephalopathy and asymmetric hemispheric cerebral atrophy. Read More

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http://dx.doi.org/10.1684/epd.2019.1036DOI Listing
February 2019
2 Reads

Electrical cortical stimulation for refractory focal epilepsy: A long-term follow-up study.

Epilepsy Res 2019 03 9;151:24-30. Epub 2019 Jan 9.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Changgung Hospital, China. Electronic address:

Objective: To report the long-term seizure control and safety of open-loop electrical cortical stimulation in patients with refractory focal epilepsy of diverse etiologies.

Methods: Six patients who received a therapeutic trial of cortical stimulation were included retrospectively. The frequency of seizures was recorded before and after implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183049
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.003DOI Listing
March 2019
14 Reads
2.015 Impact Factor

Use of Newer Anticonvulsants for the Treatment of Status Epilepticus.

Pharmacotherapy 2019 Mar 11;39(3):297-316. Epub 2019 Mar 11.

Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois.

Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety of AEDs released to the market after 2000 for SE, refractory status epilepticus (RSE), and super-refractory status epilepticus (SRSE). Read More

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http://dx.doi.org/10.1002/phar.2229DOI Listing
March 2019
3 Reads

Adult-onset Rasmussen's Syndrome with associated cortical dysplasia.

Epilepsy Behav Case Rep 2019 28;11:54-57. Epub 2018 Nov 28.

Department of Neurosurgery, UT Health San Antonio, San Antonio, TX, United States of America.

We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349012PMC
November 2018
11 Reads

Nonconvulsive status epilepticus secondary to acute porphyria crisis.

Epilepsy Behav Case Rep 2019 28;11:43-46. Epub 2018 Nov 28.

Department of Neurology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Both variegate and acute intermittent porphyria can manifest with various neurological symptoms. Although acute symptomatic seizures have been previously described, they are typically tonic-clonic and focal impaired awareness seizures. Convulsive status epilepticus and epilepsia partialis continua are rare and have been described on a case report basis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
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http://dx.doi.org/10.1016/j.ebcr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327909PMC
November 2018
24 Reads

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 02 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
5 Reads

EEG in WNV Neuroinvasive Disease.

J Clin Neurophysiol 2019 Mar;36(2):135-140

Department of Neurology, Mayo Clinic, Scottsdale, Arizona, U.S.A.

Purpose: Neuroinvasive West Nile virus (WNV) is rare, occurring in less than 1% of those infected, and may manifest as meningitis, encephalitis, and/or acute flaccid paralysis. Patients may present initially with nonspecific symptoms including fevers. Although rare, neuroinvasive WNV is associated with significant morbidity and mortality. Read More

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http://Insights.ovid.com/crossref?an=00004691-900000000-9948
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http://dx.doi.org/10.1097/WNP.0000000000000558DOI Listing
March 2019
16 Reads

Follow-up of patients with epilepsy harboring antiglycine receptor antibodies.

Epilepsy Behav 2019 Mar 12;92:103-107. Epub 2019 Jan 12.

Department of Neuroscience, Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey.

Objective: The long-term follow-up of patients with epilepsy harboring autoantibodies against the glycine receptor (also glycine receptor antibodies or GlyR-Ab) is not well-known. Our aim was to investigate the 5-year prognosis and treatment response of patients with epilepsy who were seropositive for GlyR-Ab.

Methods: Clinical features; electroencephalogram (EEG), neuroradiological, and neuropathological findings; and treatment responses of patients with epilepsy with GlyR-Ab seropositivity were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183060
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http://dx.doi.org/10.1016/j.yebeh.2018.09.034DOI Listing
March 2019
18 Reads

Focal Status Epilepticus-Related Unilateral Brain Edema: Magnetic Resonance Imaging Study of Children in Southwest China.

Pediatr Neurol 2019 Mar 23;92:60-66. Epub 2018 Nov 23.

Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, PR China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, PR China; Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing, PR China. Electronic address:

Background: Unilateral brain edema is a rare peri-ictal imaging abnormality related to focal status epilepticus. We present the largest series of these patients, describe their clinical features and magnetic resonance imaging (MRI) findings, and analyze the possible underlying pathophysiology.

Methods: We reviewed the medical records in Southwest China's largest tertiary's children's medical center from 2011 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183049
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.08.028DOI Listing
March 2019
9 Reads

Epilepsy in children with type 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks.

Eur J Paediatr Neurol 2019 Mar 21;23(2):240-247. Epub 2018 Dec 21.

Pediatric Diabetology Unit, Department of Maternal and Infantile Health, Sapienza University of Rome, Italy.

We provide an overview on the current knowledge about the association between epilepsy and type 1 diabetes mellitus (T1DM). People with T1DM have a 2-6-fold higher risk of epilepsy than the general population. The onset of T1DM anticipates the onset of epilepsy by a mean period between 1,5 and 2,8 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.006DOI Listing
March 2019
3 Reads

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences.

Curr Neuropharmacol 2018 Dec 27. Epub 2018 Dec 27.

Neurology Clinic, University of Perugia - S. Maria della Misericordia Hospital, Perugia. Italy.

After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regulation of ionic currents and the facilitation of GABAergic over glutamatergic transmission. As a result, VPA indirectly modulates neurotransmitter release and strengthens the threshold for seizure activity. Read More

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http://dx.doi.org/10.2174/1570159X17666181227165722DOI Listing
December 2018
29 Reads

Successful Surgical Treatment of Refractory Status Epilepticus in a 12-Day-Old Infant.

Pediatr Neurol 2019 Mar 23;92:73-75. Epub 2018 Nov 23.

Department of Neurosurgery, Wayne State University, Detroit, Michigan; Department of Pediatric Neurosurgery, Children's Hospital of Michigan, Detroit, Michigan.

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.11.011DOI Listing
March 2019
1.504 Impact Factor

[Etiology and clinical features of epilepsia partialis continua: an analysis of six cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1008-1014

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the etiology and clinical features of epilepsia partialis continua (EPC) in children.

Methods: A retrospective analysis was performed for the clinical features, diagnosis and treatment of six children with EPC, and the clinical and laboratory features and prognosis were compared between the children with different etiologies.

Results: There were five girls and one boy, with an onset age ranging from one year and seven months to nine years. Read More

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December 2018
14 Reads

Predictors and outcome of status epilepticus in cerebral venous thrombosis.

J Neurol 2019 Feb 19;266(2):417-425. Epub 2018 Dec 19.

Department of Neurology, Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

We report the clinico-radiological characteristics of SE in the patients with cerebral venous thrombosis (CVT), and compare the relative risk of SE in determining death and disability compared with those patients with and without self-limiting seizures. Consecutive patients with magnetic resonance venography (MRV) confirmed CVT, admitted during 2006-2017, were included. Their clinical details, risk factors, and magnetic resonance imaging and MRV findings were noted. Read More

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http://link.springer.com/10.1007/s00415-018-9145-8
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http://dx.doi.org/10.1007/s00415-018-9145-8DOI Listing
February 2019
2 Reads

Magnetoencephalographic Source Localization of the Eye Area of the Motor Homunculus.

Can J Neurol Sci 2018 Dec 17:1-7. Epub 2018 Dec 17.

1Division of Neurology,Krembil Brain Institute,University Health Network, Toronto Western Hospital,University of Toronto,Toronto, Ontario,Canada.

A patient with intractable epilepsy, previous right frontal resection, and active vagus nerve stimulation (VNS) developed new onset quasi-continuous twitching around the left eye. Electroencephalography showed no correlate to the orbicularis oculi twitches apart from myographic potentials at the left supraorbital and anterior frontal electrodes. Magnetoencephalography was performed using spatiotemporal signal space separation to suppress magnetic artifacts associated with the VNS apparatus. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.373DOI Listing
December 2018
3 Reads

Autoimmune encephalitis following alemtuzumab treatment of multiple sclerosis.

Mult Scler Relat Disord 2019 Feb 3;28:31-33. Epub 2018 Dec 3.

Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia.

Secondary autoimmune disorders are a recognised complication of alemtuzumab treatment for multiple sclerosis. We report a case of autoimmune encephalitis manifesting as a polymorphic epilepsia partialis continua / status epilepticus seven months after the second course of alemtuzumab in a patient with previous autoimmune hypothyroidism and immune thrombocytopenic purpura. An MRI revealed multifocal cortical abnormalities and neuronal loss was evident on biopsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183053
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http://dx.doi.org/10.1016/j.msard.2018.12.004DOI Listing
February 2019
10 Reads

Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps.

Epilepsia Open 2018 Dec 30;3(4):427-436. Epub 2018 Oct 30.

Department of Physiology & Medical Physics Royal College of Surgeons in Ireland (RCSI) Dublin Ireland.

There is a major unmet need for biomarkers of epilepsy. Biofluids such as blood offer a potential source of molecular biomarkers. MicroRNAs (miRNAs) fulfill several key requirements for a blood-based molecular biomarker being enriched in the brain and dysregulated in epileptic brain tissue, and manipulation of miRNAs can have seizure-suppressive and disease-modifying effects in preclinical models. Read More

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http://dx.doi.org/10.1002/epi4.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276772PMC
December 2018

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

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http://www.cmj.org/text.asp?2018/131/24/2915/247194
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http://dx.doi.org/10.4103/0366-6999.247194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302641PMC
December 2018
14 Reads

Novel Use of Responsive Neurostimulation (RNS System) in the Treatment of Super Refractory Status Epilepticus.

J Clin Neurophysiol 2018 Dec 6. Epub 2018 Dec 6.

Departments of Neurology and.

There are very few randomized controlled trials studying treatment of super refractory status epilepticus (SE), despite estimated occurrence in about 15% of SE cases and its association with high morbidity and mortality rates. Small case series and case reports have described use of neurostimulation, including vagal nerve stimulation, transcranial magnetic stimulation, and deep brain stimulation, to treat super refractory SE when medical interventions have failed. To our knowledge, this is the first reported case of responsive neurostimulation being used to successfully treat a case of super refractory SE. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000541DOI Listing
December 2018

Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec;20(6):545-550

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1017DOI Listing
December 2018
8 Reads

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec;20(6):541-544

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

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http://dx.doi.org/10.1684/epd.2018.1011DOI Listing
December 2018
3 Reads