Cell Tissue Res 2021 Apr 27. Epub 2021 Apr 27.
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52 , 20246, Hamburg, Germany.
Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss. Recently, significant advances were made in understanding genetic factors, podocyte intrinsic mechanisms, and adaptive mechanisms causing FSGS. However, while most cases of nephrotic FSGS are being treated with immunosuppressants, the underlying immune dysregulation, involved immune cells, and soluble factors are only incompletely understood. Read More