2,464 results match your criteria Focal Nodular Hyperplasia


Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series.

Dig Dis 2019 Feb 14:1-6. Epub 2019 Feb 14.

Department of Integrated Medicine, Federal University of Rio Grande do Norte/University Hospital Onofre Lopes, Natal, Rio Grande do Norte, Brazil.

Background: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. Read More

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http://dx.doi.org/10.1159/000496430DOI Listing
February 2019

Paraduodenal inflammatory pseudotumor masquerading as malignancy.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

A 30-year-old woman presented with severe abdominal pain and abdominal distension. CT demonstrated two intra-abdominal masses, one involving the left lateral segment of the liver and the other adjacent to the duodenum. Initial biopsies were consistent with focal nodular hyperplasia of the liver and non-specific lymphocytic infiltrate in the paraduodenal mass. Read More

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http://dx.doi.org/10.1136/bcr-2018-226460DOI Listing
February 2019

The impact of body mass index on perioperative outcomes after robotic liver resection.

J Robot Surg 2019 Feb 1. Epub 2019 Feb 1.

Southeastern Center for Digestive Disorder and Hepatopancreatobiliary Cancer, Advanced Minimally Invasive and Robotic Surgery, Florida Hospital Tampa, 3000 Medical Park Dr, Suite #500, Tampa, USA.

High body mass index (BMI) is associated with other multiple comorbidities such as non-alcoholic fatty liver disease, steatohepatitis, liver cirrhosis, and cardiopulmonary diseases, which can impact the perioperative outcomes following liver resection. We aimed to study the impact of BMI on perioperative outcomes after robotic liver resection. All the patients undergoing robotic liver resection between 2013 and 2017 were prospectively followed. Read More

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http://link.springer.com/10.1007/s11701-019-00923-4
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http://dx.doi.org/10.1007/s11701-019-00923-4DOI Listing
February 2019
3 Reads

Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers.

Clin Mol Hepatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Gadoxetic acid, a hepatocyte-specific magnetic resonance imaging (MRI) contrast agent, has emerged as an important tool for hepatocellular carcinoma (HCC) diagnosis. Gadoxetic acid-enhanced MRI is useful for the evaluation of earlystage HCC, diagnosis of HCC precursor lesions, and highly sensitive diagnosis of HCC. Furthermore, functional information provided by gadoxetic acid-enhanced MRI can aid in the characterization of focal liver lesions. Read More

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http://dx.doi.org/10.3350/cmh.2018.0107DOI Listing
January 2019

Liver Imaging Techniques: Recognition of Uveal Melanoma Metastases.

Ocul Oncol Pathol 2018 Jun 19;4(4):254-260. Epub 2018 Jan 19.

Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The liver is the most common site for metastases of several primary malignancies including uveal melanoma.

Methods: Review of imaging characteristics of incidental common benign liver lesions including hepatic cyst, hemangioma, focal nodular hyperplasia, and hepatic adenoma and contrasting them with uveal melanoma metastases.

Results: Benign hepatic lesions may be cystic or, if solid, relatively stable in size over time. Read More

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https://www.karger.com/Article/FullText/485424
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http://dx.doi.org/10.1159/000485424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322083PMC
June 2018
6 Reads

Hepatic Lesions Associated with McCune Albright Syndrome.

J Pediatr Gastroenterol Nutr 2019 Jan 4. Epub 2019 Jan 4.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

McCune Albright Syndrome (MAS) results from a GNAS gene mutation. It is associated with café-au-lait macules, fibrous dysplasia, and several endocrinopathies to include gonadotropin-independent precocious puberty, growth hormone excess, Cushing syndrome, thyroid disease, and renal phosphate wasting. It is recognised to be a rare cause of neonatal cholestasis. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002266DOI Listing
January 2019
1 Read

Update on the pathology of liver neoplasms.

Ann Diagn Pathol 2018 Oct 12;38:126-137. Epub 2018 Oct 12.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Many advances have developed in the pathology of liver tumors in the recent decade. Examples of these advances include the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, subtyping of hepatocellular adenomas using molecular and immunohistochemical methods, the unraveling of the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, and the more unified classification and terminology in intrahepatic bile duct tumors and their precursor lesions. Nevertheless, challenges still remain, e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.005DOI Listing
October 2018
2 Reads

18F-choline PET/CT incidental thyroid uptake in patients studied for prostate cancer.

Endocrine 2018 Dec 29. Epub 2018 Dec 29.

Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.

Purpose: Thyroid incidental uptake is defined as a thyroid uptake incidentally detected by imaging examinations performed for non-thyroid disease. The aim of this study was to establish the prevalence and the pathological nature of focal thyroid incidental uptake (FTIU) among patients studied with 18F-choline-PET/CT.

Materials And Methods: We retrospectively evaluated 368 patients who performed 18F-choline-PET/CT between June 2016 and August 2018. Read More

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http://dx.doi.org/10.1007/s12020-018-01832-6DOI Listing
December 2018
2 Reads

SIUMB guidelines and recommendations for the correct use of ultrasound in the management of patients with focal liver disease.

J Ultrasound 2018 Dec 22. Epub 2018 Dec 22.

Unit of Ultrasound in Internal Medicine, Department of Medicine and Science of Aging, "G. d'Annunzio" University of Chieti, Chieti, Italy.

The present document describes the SIUMB (Italian Society of Ultrasound in Medicine and Biology) guidelines for the use of ultrasound in the management of focal liver disease. The aim of the paper is to provide a clinical practice guideline for Italian physicians who are approaching the ultrasound study of a focal liver lesion. In particular, these guidelines provide simple indications, recommendations and general practice advices for the correct use of contrast-enhanced ultrasound (CEUS) in this scenario. Read More

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http://dx.doi.org/10.1007/s40477-018-0343-0DOI Listing
December 2018
1 Read

Hamartomas and malformations of the liver.

Semin Diagn Pathol 2019 Jan 17;36(1):39-47. Epub 2018 Nov 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Hamartomas and malformations of the liver are rare and can lead to diagnostic challenges. Most present as mass lesions that can mimic true neoplasms of the liver on imaging and sometimes on histology, one example being focal nodular hyperplasia. The primary cell type in the hamartomas and malformations can be biliary, vascular, or hepatic. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.11.005DOI Listing
January 2019
3 Reads

Value of Texture Analysis on Gadoxetic Acid-Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia.

AJR Am J Roentgenol 2018 Dec 17:1-9. Epub 2018 Dec 17.

1 Department of Radiology, Abdominal Imaging Division, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213.

Objective: The objective of our study was to assess the diagnostic performance of texture analysis (TA) on gadoxetic acid-enhanced MR images for differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH).

Materials And Methods: This study included 40 patients (39 women and one man) with 51 HCAs and 28 patients (27 women and one man) with 32 FNH lesions. All lesions were histologically proven with preoperative MRI performed with gadoxetic acid. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20182
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http://dx.doi.org/10.2214/AJR.18.20182DOI Listing
December 2018
9 Reads

Solid Pseudopapillary Tumor of the Pancreas - Rare Neoplastic Disease in 20-Year-Old Woman.

Klin Onkol 2018 ;31(5):376-379

Introduction: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively rare affliction representing less than 4% of cystic PC. Read More

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http://dx.doi.org/10.14735/amko2018376DOI Listing
January 2018
1 Read

The orange-cross section appearance in focal nodular hyperplasia.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Diagnostic Imaging Department, Escola Paulista de Medicina / UNIFESP, São Paulo - Brazil, Rua Napoleão de Barros, 800, São Paulo, 04024-002, Brazil.

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http://dx.doi.org/10.1007/s00261-018-1866-8DOI Listing
December 2018

Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2018 Nov 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.006DOI Listing
November 2018
3 Reads

Treatment-related Focal Nodular Hyperplasia Mimicking Liver Metastases.

J Pediatr Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Departments of Radiology.

A 7-year-old patient with a stage 4 neuroblastoma underwent chemotherapy, surgery, myeloablative therapy, external beam radiotherapy, and Isoretinoin treatment. A posttreatment magnetic resonance examination performed administering gadoteric acid as contrast agent showed 2 new hypervascular hepatic lesions, suspicious for metastases. A second magnetic resonance imaging performed using a liver-specific contrast medium (gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid) demonstrated that these lesions were consistent with treatment-related focal nodular hyperplasia. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001362DOI Listing
November 2018
1 Read

The "spoke wheel" sign in hepatic focal nodular hyperplasia.

Abdom Radiol (NY) 2018 Nov 28. Epub 2018 Nov 28.

Section of Radiological Sciences, Di.Bi.Med., University of Palermo, Via del Vespro 127, 90127, Palermo, Italy.

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http://dx.doi.org/10.1007/s00261-018-1852-1DOI Listing
November 2018

[Exploring focal liver lesions with contrastenhanced ultrasonography].

Rev Med Liege 2018 Nov;73(11):592-596

Service de Radiodiagnostic, CHU de Liège, Belgique.

Noninvasive diagnosis of focal liver lesions is usually based on unenhanced ultrasonography, computed tomography, or magnetic resonance. Contrast-enhanced ultrasonography (CEUS) can be used among the other imaging modalities in evaluating these lesions. The technique requires the intravenous injection of contrast media. Read More

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November 2018
11 Reads

Development of Focal Nodular Hyperplasia after Cyclophosphamide-Based Chemotherapy in a Patient with Breast Cancer.

Case Reports Hepatol 2018 22;2018:5409316. Epub 2018 Oct 22.

Department of Breast Surgery, The Third Affiliated Hospital of Suzhou University, 185 Juqian Road, 213003 Changzhou, China.

Focal nodular hyperplasia (FNH) is the second most common liver cell-derived benign tumor. It is postulated that chemotherapy-induced hepatic circulatory abnormalities, like sinusoidal obstruction syndrome (SOS), could lead to the development of FNH. Cyclophosphamide was also reported to induce SOS in a synergistic effect with total body irradiation. Read More

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http://dx.doi.org/10.1155/2018/5409316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217880PMC
October 2018
1 Read

MicroRNA Expression in Focal Nodular Hyperplasia in Comparison with Cirrhosis and Hepatocellular Carcinoma.

Pathol Oncol Res 2018 Nov 9. Epub 2018 Nov 9.

2nd Department of Pathology, Semmelweis University, Ulloi 93, Budapest, H-1091, Hungary.

The liver disease focal nodular hyperplasia (FNH) has several histological features that resemble hepatic cirrhosis. Since cirrhosis may develop further into hepatocellular carcinoma (HCC) contrary to FNH, the aim of the present study was to identify microRNAs (miRNA), which, by their altered expression levels, may be associated with the benign, tumor-like nature of FNH. Altogether 106 surgically removed formalin-fixed paraffin-embedded liver samples were selected, including 22 FNH, 45 cirrhosis, 24 HCC and 15 normal liver tissues. Read More

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http://link.springer.com/10.1007/s12253-018-0528-z
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http://dx.doi.org/10.1007/s12253-018-0528-zDOI Listing
November 2018
6 Reads

Primary Application of Micro-Flow Imaging Technology in the Diagnosis of Hepatic Tumors.

Ultrasound Med Biol 2019 Feb 5;45(2):395-401. Epub 2018 Nov 5.

Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai Institute of Medical Imaging, Shanghai, China. Electronic address:

The purpose of the study was to evaluate the vascular architecture of focal liver lesions with the newly released non-contrast micro-flow imaging (MFI) technique. Eighty patients with 80 hepatic tumors were enrolled in this study. The richness of displayed blood flow was first compared with color Doppler flow imaging using grades according to Adler's method. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.09.025DOI Listing
February 2019
2.214 Impact Factor

Personalized 3D-Printed Transparent Liver Model Using the Hepatobiliary Phase MRI: Usefulness in the Lesion-by-Lesion Imaging-Pathologic Matching of Focal Liver Lesions-Preliminary Results.

Invest Radiol 2019 Mar;54(3):138-145

Department of Radiology, Seoul National University College of Medicine.

Purpose: The aim of this study was to investigate the usefulness of a personalized, 3-dimensional (3D)-printed, transparent liver model with focal liver lesions (FLLs) for lesion-by-lesion imaging-pathologic matching.

Materials And Methods: This preliminary, prospective study was approved by our institutional review board, and written informed consent was obtained. Twenty patients (male-to-female ratio, 13:7; mean age, 56 years) with multiple FLLs, including at least one presumed malignant, or an indeterminate lesion 10 mm or less on the preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI), were included. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000521DOI Listing
March 2019
2 Reads

Simultaneous occurrence of five prothrombotic induced vaso-occlusive phenomena and focal nodular hyperplasia due to prolonged use of combined oral contraceptive pills.

BJR Case Rep 2018 15;4(2):20170070. Epub 2017 Dec 15.

M.P Shah Hospital, University of Nairobi, Nairobi, Kenya.

This is a rare case of a patient simultaneously presenting with five complications associated with the prolonged (5 years) use of combined oral contraceptives. The two main ingredients of combined oral contraceptives responsible for thromboembolism are estrogen (estradiol) and progestogen (progestin). Progestins are linked with occlusion of arteries while estrogens can induce both arterial and venous thrombosis. Read More

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http://dx.doi.org/10.1259/bjrcr.20170070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159115PMC
December 2017
2 Reads

Liver Multiacinar Regenerative Nodules: Imaging Findings and Clinical Implications.

Acta Med Port 2018 Sep 28;31(9):470-477. Epub 2018 Sep 28.

Imaging Department. Faculty of Medicine. University Centre Hospitals of Coimbra (CHUC). Coimbra. Portugal.

Introduction: Multiacinar regenerative nodules are benign hepatocellular nodules related to vascular disturbances of the liver. They strongly resemble conventional focal nodular hyperplasia but are connected to different clinical settings, typically chronic liver disease. The purpose of the present study was to describe the key imaging features of these lesions and compare them with a control arm of focal nodular hyperplasia. Read More

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http://dx.doi.org/10.20344/amp.10259DOI Listing
September 2018
11 Reads

Heterogeneity of Fibrosis in Liver Biopsies of Patients With Heart Failure Undergoing Heart Transplant Evaluation.

Am J Surg Pathol 2018 Dec;42(12):1617-1624

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center.

Liver biopsies are commonly performed in heart transplant candidates to confirm congestive hepatopathy (CH) and to assess the degree of fibrosis. Heterogeneity of fibrosis is frequent in CH, making it difficult to stage fibrosis. In this study, we evaluated the prevalence of heterogeneity of fibrosis and nodular regenerative hyperplasia (NRH) in liver biopsies with CH secondary to heart failure. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001163DOI Listing
December 2018
9 Reads

Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability.

Pediatr Radiol 2019 Jan 28;49(1):82-90. Epub 2018 Sep 28.

Department of Radiology, Kings College Hospital, Denmark Hill, London, SE5 9RS, UK.

Background: Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.

Objective: To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.

Materials And Methods: Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Read More

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http://link.springer.com/10.1007/s00247-018-4250-5
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http://dx.doi.org/10.1007/s00247-018-4250-5DOI Listing
January 2019
8 Reads

Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images.

Abdom Radiol (NY) 2018 Sep 28. Epub 2018 Sep 28.

Abdominal Imaging Division, Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Purpose: To explore the value of CT texture analysis (CTTA) for differentiation of focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA) on contrast-enhanced CT (CECT).

Methods: This is a retrospective, IRB-approved study conducted in a single institution. A search of the medical records between 2008 and 2017 revealed 48 patients with 70 HCA and 50 patients with 62 FNH. Read More

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http://dx.doi.org/10.1007/s00261-018-1788-5DOI Listing
September 2018
2 Reads

Fibrinolytic System Changes in Liver Surgery: A Pilot Observational Study.

Front Med (Lausanne) 2018 11;5:253. Epub 2018 Sep 11.

Riga Stradins University, Riga, Latvia.

Bleeding occurs frequently in liver surgery. Unbalance between tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) concentrations might increase bleeding. Our aim was to analyze perioperative fibrinolytic changes during liver surgery. Read More

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http://dx.doi.org/10.3389/fmed.2018.00253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141717PMC
September 2018
5 Reads

Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia.

J Magn Reson Imaging 2019 Mar 25;49(3):700-710. Epub 2018 Sep 25.

Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Current imaging guidelines do not specify the preferred hepatobiliary contrast agent when differentiating hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH) on MRI.

Purpose: To analyze intrapatient differences in the hepatobiliary phase (HBP) after use of both gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI to differentiate HCA from FNH.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26227DOI Listing
March 2019
4 Reads

The role of acoustic radiation force impulse elastography in the differentiation of benign and malignant focal liver masses.

Turk J Gastroenterol 2018 07;29(4):456-463

Department of Radiology, Gaziantep University School of Medicine, Gaziantep, Turkey.

Background/aims: The aim of this study was to evaluate elasticity of benign and malign focal liver lesions and surrounding parenchyma as measured by acoustic radiation force impulse (ARFI).

Materials And Methods: 34 hemangiomas, 4 focal nodular hyperplasia (FNH), 10 hepatocellular carcinoma (HCC) and 22 metastatic lesions from a total of 62 patients were examined with ARFI elastography. ARFI measurements for each tumor type were expressed as mean ± standard deviation for liver mass and surrounding parenchyma. Read More

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http://www.turkjgastroenterol.org/eng/makale/5336/308/Full-T
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http://dx.doi.org/10.5152/tjg.2018.11710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284630PMC
July 2018
14 Reads

Gastric Cancer Screening in Common Variable Immunodeficiency.

J Clin Immunol 2018 Oct 15;38(7):768-777. Epub 2018 Sep 15.

Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia.

Individuals with common variable immunodeficiency (CVID) have an increased risk of gastric cancer, and gastrointestinal lymphoma, yet screening for premalignant gastric lesions is rarely offered routinely to these patients. Proposed screening protocols are not widely accepted and are based on gastric cancer risk factors that are not applicable to all CVID patients. Fifty-two CVID patients were recruited for screening gastroscopy irrespective of symptoms or blood results and were compared to 40 controls presenting for gastroscopy for other clinical indications. Read More

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http://dx.doi.org/10.1007/s10875-018-0546-3DOI Listing
October 2018
5 Reads
3.184 Impact Factor

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.

Liver Int 2019 Jan 8;39(1):158-167. Epub 2018 Oct 8.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background And Aims: Hepatobiliary phase (HBP) Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) has increased the accuracy in differentiating focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA). However, the ability of this technique to distinguish HCA subtypes remains controversial. The aim of this study was to investigate the expression of hepatocyte transporters (OATPB1/B3, MRP2, MRP3) in HCA subtypes, hence to understand their MRI signal intensity on HBP Gd-EOB-DTPA-enhanced MRI. Read More

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http://doi.wiley.com/10.1111/liv.13964
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http://dx.doi.org/10.1111/liv.13964DOI Listing
January 2019
12 Reads

Determination of Hepatocellular Carcinoma and Characterization of Hepatic Focal Lesions with Adaptive Multi-Exponential Intravoxel Incoherent Motion Model.

Transl Oncol 2018 Dec 11;11(6):1370-1378. Epub 2018 Sep 11.

CREATIS, CNRS UMR 5220-INSERM U1206-University Lyon 1-INSA Lyon-University Jean Monnet Saint-Etienne, Lyon, 69621, France.

Purpose: To distinguish hepatocellular carcinoma (HCC) from other types of hepatic lesions with the adaptive multi-exponential IVIM model.

Methods: 94 hepatic focal lesions, including 38 HCC, 16 metastasis, 12 focal nodular hyperplasia, 13 cholangiocarcinoma, and 15 hemangioma, were examined in this study. Diffusion-weighted images were acquired with 13 b values (b = 0, 3, …, 500 s/mm) to measure the adaptive multi-exponential IVIM parameters, namely, pure diffusion coefficient (D), diffusion fraction (f), pseudo-diffusion coefficient (D*) and perfusion-related diffusion fraction (f) of the ith perfusion component. Read More

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http://dx.doi.org/10.1016/j.tranon.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139005PMC
December 2018
6 Reads

CD34, PCNA and CK19 expressions in AFP- hepatocellular carcinoma.

Authors:
D-J Cui Y Wu D-H Wen

Eur Rev Med Pharmacol Sci 2018 Aug;22(16):5200-5205

Department of Infectious Disease, The First Affiliated Hospital of Qiqihar Medical School, Qiqihar, Heilongjiang, China.

Objective: Primary hepatocellular carcinoma (HCC) is one of the most important malignant liver cancers in clinic. Serum alpha-fetoprotein (AFP) positive expression is an important examination index. However, there are some hepatocellular carcinoma patients show negative AFP expressions. Read More

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http://dx.doi.org/10.26355/eurrev_201808_15717DOI Listing
August 2018
1 Read

Late effects in high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell rescue.

Pediatr Blood Cancer 2019 Jan 27;66(1):e27421. Epub 2018 Aug 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Background: Current treatment strategies have improved the outcome of high-risk neuroblastoma (HRNB) at the cost of increasing acute and late effects of treatment. Although high-dose chemotherapy with stem cell rescue (HDC-SCR) has replaced total body irradiation (TBI) based HRNB therapy, late effects of therapy remain a significant concern.

Objectives: To describe late effects prevalence, severity, and risks after HDC-SCR. Read More

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http://dx.doi.org/10.1002/pbc.27421DOI Listing
January 2019
3 Reads

Hepatocellular Carcinoma in a Patient with Hereditary Hemorrhagic Telangiectasia.

Intern Med 2018 Dec 24;57(24):3545-3549. Epub 2018 Aug 24.

Department of Hepatobiliary and Pancreatic Surgery, Japanese Red Cross Society Himeji Hospital, Japan.

A 76-year-old woman with hereditary hemorrhagic telangiectasia (HHT) showed elevated serum hepatobiliary enzyme levels, and abdominal imaging studies revealed a hepatic tumor. Her serum alpha-fetoprotein level was 759.5 ng/mL. Read More

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http://dx.doi.org/10.2169/internalmedicine.1056-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355409PMC
December 2018
13 Reads

Gadoxetic Acid-Enhanced Hepatobiliary-Phase Magnetic Resonance Imaging for Delineation of Focal Nodular Hyperplasia: Superiority of High-Flip-Angle Imaging.

J Comput Assist Tomogr 2018 Sep/Oct;42(5):667-674

National Center for Tumor Diseases, Medical Oncology.

Objective: The aim of this study was to investigate whether hepatobiliary-phase (HBP) flip-angle (FA) increase to 25° improves conspicuity of focal nodular hyperplasia (FNH) and enables HBP delay reduction.

Methods: This was a retrospective study of 23 patients with 46 FNHs. In each patient, HBP was performed with reduced-delay high FA (early/high), standard-delay high FA (late/high), and standard-delay standard FA (standard). Read More

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http://dx.doi.org/10.1097/RCT.0000000000000777DOI Listing
September 2018
3 Reads

Hepatocyte-specific contrast media: not so simple.

Pediatr Radiol 2018 08 4;48(9):1245-1255. Epub 2018 Aug 4.

Department of Radiology, MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3026, USA.

Hepatocyte-specific contrast media are gadolinium chelates that are taken up by hepatocytes and partially cleared via the biliary tree. The absence of lesional uptake of the contrast media in the hepatobiliary phase is a marker of either the absence of hepatocytes or of poorly functioning, neoplastic hepatocytes. Uptake of the contrast media in the hepatobiliary phase, whether equal to or greater than background liver, reflects the presence of hepatocytes but does not equate to absence of neoplasia. Read More

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http://dx.doi.org/10.1007/s00247-018-4108-xDOI Listing
August 2018
3 Reads

Magnetic resonance imaging features of common focal liver lesions in children.

Authors:
Prakash M Masand

Pediatr Radiol 2018 08 4;48(9):1234-1244. Epub 2018 Aug 4.

Cardiovascular Imaging, Department of Pediatric Radiology, Texas Children's Hospital, 6701 Fannin St., Houston, TX, 77030, USA.

Magnetic resonance imaging (MRI) is commonly used to characterize focal liver masses in the pediatric population. MRI is the preferred modality because of its superior contrast resolution and utility for obtaining functional sequences such as diffusion-weighted imaging (DWI). MR exams performed with a hepatocyte-specific gadolinium-based contrast agent can characterize focal liver lesions, which helps in differentiating a common benign entity such as focal nodular hyperplasia from other liver pathology when the background liver is normal. Read More

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http://dx.doi.org/10.1007/s00247-018-4218-5DOI Listing
August 2018
15 Reads

Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy.

Eur J Gastroenterol Hepatol 2018 10;30(10):1254-1255

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, VU University Medical Centre, Amsterdam, The Netherlands.

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http://Insights.ovid.com/crossref?an=00042737-201810000-0002
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http://dx.doi.org/10.1097/MEG.0000000000001218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133222PMC
October 2018
1 Read

Regression of hepatocellular adenoma after bariatric surgery in severe obese patients.

Liver Int 2018 Dec 10;38(12):2134-2136. Epub 2018 Aug 10.

Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands.

Background & Aim: Obesity and metabolic syndrome are increasingly recognized as risk factors for hepatocellular adenomas (HCA). There is still sparse evidence whether weight loss or bariatric surgery could induce HCA regression in these patients. In this brief report we describe the effect of weight loss on HCA regression in severe obese patients that had undergone bariatric surgery in our centre. Read More

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http://dx.doi.org/10.1111/liv.13934DOI Listing
December 2018
1 Read

Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation.

Br J Cancer 2018 Aug 11;119(3):282-290. Epub 2018 Jul 11.

Children's Hospital, University of Cologne, Cologne, Germany.

Background: This study was done to investigate the long-term event free and overall survival of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT), compared to maintenance chemotherapy (MT). Patterns of recurrences and late sequelae of both arms were analysed.

Methods: A randomised open label trial was conducted nationwide during 1997-2004 in Germany and Switzerland. Read More

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http://dx.doi.org/10.1038/s41416-018-0169-8DOI Listing
August 2018
1 Read

Liver involvement in hereditary hemorrhagic telangiectasia.

Abdom Radiol (NY) 2018 Jul 10. Epub 2018 Jul 10.

Gastroenterology and Digestive Endoscopy Department, Maggiore Hospital, ASST Crema, 26013, Crema, Italy.

Liver vascular malformations (VMs) in hereditary hemorrhagic telangiectasia (HHT) are typically diffuse and can evolve from small telangiectasias to large arteriovenous malformations, with various stages of severity. Doppler US is the ideal first-line investigation for the assessment of liver VMs in HHT due to its safety, tolerability, low costs, and accuracy for the detection of liver VMs. The caliber, course, and flow characteristics in the hepatic artery, portal vein, and hepatic vein as determined by Doppler US, together with parenchymal abnormalities, support the diagnosis of liver VMs in HHT and their severity staging. Read More

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http://dx.doi.org/10.1007/s00261-018-1671-4DOI Listing
July 2018
11 Reads

Surgical management of children and adolescents with upfront completely resected hepatocellular carcinoma.

Pediatr Blood Cancer 2018 Nov 3;65(11):e27293. Epub 2018 Jul 3.

Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Hepatocellular carcinoma (HCC) is an aggressive malignant neoplasm that is often chemoresistant. Complete surgical resection remains the mainstay of therapy. The role of liver transplantation (LT) in pediatric HCC is in evolution, as is the role of adjuvant chemotherapy for stage I disease. Read More

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http://doi.wiley.com/10.1002/pbc.27293
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http://dx.doi.org/10.1002/pbc.27293DOI Listing
November 2018
18 Reads

Application of real-time three-dimensional contrast-enhanced ultrasound using SonoVue for the evaluation of focal liver lesions: a prospective single-center study.

Am J Transl Res 2018 15;10(5):1469-1480. Epub 2018 May 15.

Department of Medical Ultrasound, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong Province, P. R. China.

Focal liver lesions (FLLs) include a variety of benign and malignant tumors, and are usually differential diagnosed by ultrasonography. However, traditional two-dimensional contrast-enhanced ultrasound (2D-CEUS) can evaluate a single slice of a lesion. It cannot fully display perfusion of a lesion and the relationship with the surrounding tissues, which may lead to misdiagnosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992562PMC
May 2018
7 Reads

Indications for liver surgery in benign tumours.

Eur Surg 2018 22;50(3):125-131. Epub 2018 May 22.

1Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Background: Management of benign liver tumours (BLT) is still object of discussion. Uncertainty still exists about patient selection, details of management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies for management of the most common benign solid tumours are recapitulated in this article. Read More

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http://dx.doi.org/10.1007/s10353-018-0536-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968066PMC
May 2018
5 Reads

Large-scale screening of circulating microRNAs in individuals with HIV-1 mono-infections reveals specific liver damage signatures.

Antiviral Res 2018 Jul 25;155:106-114. Epub 2018 May 25.

Internal Medicine Department, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona, Spain.

Human immunodeficiency virus type 1 (HIV-1)-induced inflammation and/or long-term antiretroviral drug toxicity may contribute to the evolution of liver disease. We investigated circulating plasma microRNAs (miRNAs) as potential biomarkers of liver injury in patients mono-infected with HIV-1. We performed large-scale deep sequencing analyses of small RNA level on plasma samples from patients with HIV-1 mono-infection that had elevated or normal levels of alanine aminotransferase (ALT) or focal nodular hyperplasia (FNH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183021
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http://dx.doi.org/10.1016/j.antiviral.2018.05.008DOI Listing
July 2018
4 Reads

Hepatocellular nodules in vascular liver diseases.

Virchows Arch 2018 Jul 26;473(1):33-44. Epub 2018 May 26.

Inserm, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, Université de Bordeaux, 33076, Bordeaux, France.

Hepatocellular nodules have been recognized in vascular liver diseases for a long time and mostly described and studied in the imaging literature. Some confusions in their identification and overlap in their definitions exist, especially in this specific clinical context. Pathology descriptions report the development of nodular regenerative hyperplasia, large regenerative nodule, and focal nodular hyperplasia, as adaptive responses of the liver parenchyma to the modified blood flow. Read More

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http://dx.doi.org/10.1007/s00428-018-2373-6DOI Listing
July 2018
4 Reads

Pure laparoscopic right hemihepatectomy using the caudodorsal side approach (with videos).

J Hepatobiliary Pancreat Sci 2018 Jul 15;25(7):335-341. Epub 2018 Jun 15.

Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Background: In our process of standardizing laparoscopic right hemihepatectomy (Lap-RH), we found several advantages of the laparoscopic caudate lobe first approach by using a unique laparoscopic caudodorsal view.

Methods: Between April 2012 and October 2017, 21 patients underwent pure Lap-RH at our hospital. The mean patient age was 62 years (range 36-75 years), and there were more male than female patients (66. Read More

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http://dx.doi.org/10.1002/jhbp.563DOI Listing
July 2018
10 Reads

Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma.

J Clin Ultrasound 2018 Jul 8;46(6):380-385. Epub 2018 May 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Purpose: Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT).

Methods: The study included 88 patients (65 FNH, 23 HCA). Read More

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http://dx.doi.org/10.1002/jcu.22603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033170PMC
July 2018
8 Reads