168,447 results match your criteria Focal Nodular Hyperplasia

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Read More

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Lesion loci of impaired affective prosody: A systematic review of evidence from stroke.

Brain Cogn 2021 Jun 9;152:105759. Epub 2021 Jun 9.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, United States.

Affective prosody, or the changes in rate, rhythm, pitch, and loudness that convey emotion, has long been implicated as a function of the right hemisphere (RH), yet there is a dearth of literature identifying the specific neural regions associated with its processing. The current systematic review aimed to evaluate the evidence on affective prosody localization in the RH. One hundred and ninety articles from 1970 to February 2020 investigating affective prosody comprehension and production in patients with focal brain damage were identified via database searches. Read More

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Improving mAb capture productivity on batch and continuous downstream processing using nanofiber PrismA adsorbents.

J Biotechnol 2021 Jun 9. Epub 2021 Jun 9.

Ology Bioservices, Process Development, 13200 NW Nano Ct., Alachua, FL, 32615, USA. Electronic address:

Improving productivity and decreasing costs for biotherapeutic agents has been a focal driving force in the manufacturing of biologics. Advances in upstream processes have been continuously outpacing the ability for downstream operations to purify biologics, especially monoclonal antibodies. Continuous chromatography has several benefits for biologic purification including automated control, decreased labor, improved productivity, and more consistent product attributes. Read More

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Successful Reuse of Kidney Graft After Early Recurrence of Primary Focal and Segmental Glomerulosclerosis.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Nephrology, Dialysis, Transplantation, and Apheresis, Lille University, Regional and University Hospital Center of Lille, F-59037 Lille, France.

Primary focal and segmental glomerulosclerosis (pFSGS) frequently recurs after transplantation and is associated with a poor prognosis. We describe here the successful kidney graft reuse in an adult recipient, eight months after early pFSGS recurrence resistant to all available therapeutics. Patient 1, a 23-year-old man, followed for kidney failure secondary to pFSGS, was first transplanted in 2018 with a deceased donor graft. Read More

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Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States.

Pediatr Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, USA.

For two decades, pediatric contrast US has been well accepted throughout Europe and other parts of the world outside the United States because of its high diagnostic efficacy and extremely favorable safety profile. This includes intravenous (IV) administration, contrast-enhanced US (CEUS) and the intravesical application, contrast-enhanced voiding urosonography (ceVUS). However, the breakthrough for pediatric contrast US in the United States did not come until 2016, when the U. Read More

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Optoregulated force application to cellular receptors using molecular motors.

Nat Commun 2021 06 11;12(1):3580. Epub 2021 Jun 11.

INM - Leibniz Institute for New Materials, Saarbrücken, Germany.

Progress in our understanding of mechanotransduction events requires noninvasive methods for the manipulation of forces at molecular scale in physiological environments. Inspired by cellular mechanisms for force application (i.e. Read More

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Meningioangiomatosis: an uncommon cause of focal epilepsy with characteristic neuroimaging and neuropathology.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Neuropathology, Greater Manchester Neurosciences Centre, Salford, UK.

A 3-year-old boy presented with acute onset of prolonged right sided focal seizures with secondary generalisation. The investigation findings were suggestive of a neoplastic process more than an inflammatory process. Decision to perform brain biopsy from the lesion to establish the precise nature of lesion was undertaken. Read More

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The role of semiquantitative evaluation of lympho-vascular space invasion in early stage cervical cancer patients.

Gynecol Oncol 2021 Jun 9. Epub 2021 Jun 9.

Unit of Gynecologic Oncology, Department of Woman, Child and Public Health, A. Gemelli, IRCCS, University Hospital Foundation, Rome, Italy; Catholic University of the Sacred Heart, Rome, Italy.

Objective: Lymph vascular space involvement (LVSI) is one of the most important prognostic factors in early stage cervical cancer. Its qualitative evaluation represents a milestone for patient risk stratification and treatment choice, but a semi-quantitative analysis of LVSI may offer a more truthful risk model, as already demonstrated for endometrial cancer. The present study aims to investigate the performances of a semi-quantitative evaluation of LVSI in terms of patient risk assessment. Read More

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Autologous Matrix-Induced Chondrogenesis (AMIC) for Isolated Retropatellar Cartilage Lesions: Outcome after a Follow-Up of Minimum 2 Years.

Cartilage 2021 Jun 11:19476035211021908. Epub 2021 Jun 11.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Purpose: To evaluate autologous matrix-induced chondrogenesis (AMIC) for isolated focal retropatellar cartilage lesions and the influence of patellofemoral (PF) anatomy on clinical outcomes at a minimum of 2-year follow-up.

Methods: Twenty-nine consecutive patients (31 knees) who underwent retropatellar AMIC with a mean age of 27.9 ± 11. Read More

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Reappearance of Neurological Deficits in Pathologic Brain: Are Sedatives and Opioids Culprits? A Systematic Review.

J Neurosurg Anesthesiol 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Medicine, University of Ottawa Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University Health Network, Toronto, ON Section Intervention Neuroradiology, Department of Radiology, University of Manitoba, Winnipeg, MB, Canada Department of Pathology, Institute of Cardiovascular Physiopathology, University of Buenos Aires, Buenos Aires, Argentina.

Following a brain insult, focal neurological deficits may develop. Despite resolution of these deficits with time, the subsequent administration of sedative medications and opioids may lead to recrudescence of previous neurological deficits. Therefore, the present systematic review aims to explore the role of different sedatives and opioid analgesics at reproducing focal neurological deficits in patients with previous brain insults undergoing surgery. Read More

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Identifying research priorities to improve the health of incarcerated populations: results of citizens' juries in Australian prisons.

Lancet Public Health 2021 Jun 8. Epub 2021 Jun 8.

School of Population Health, University of New South Wales (UNSW Sydney), Sydney, NSW, Australia.

Health disparities in incarcerated populations should guide investment in the health care and research of these communities. Although users of health-care services are important in providing input into decisions about research, the voices of people in prison are absent regarding research into their health. In this Health Policy paper, we present priorities for research into the health of people in prison according to people in prison themselves. Read More

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Bioecology of fall armyworm Spodoptera frugiperda (J. E. Smith), its management and potential patterns of seasonal spread in Africa.

PLoS One 2021 11;16(6):e0249042. Epub 2021 Jun 11.

International Centre of Insect Physiology and Ecology, Nairobi, Kenya.

Fall armyworm, Spodoptera frugiperda (J. E. Smith) has rapidly spread in sub-Saharan Africa (SSA) and has emerged as a major pest of maize and sorghum in the continent. Read More

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Arterial Spin Labeling Reveals Elevated Cerebral Blood Flow with Distinct Clusters of Hypo- and Hyperperfusion after Traumatic Brain Injury.

J Neurotrauma 2021 Jun 10. Epub 2021 Jun 10.

The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. In this study, we used arterial spin labeling (ASL) to quantify cross-sectional and longitudinal changes in cerebral blood flow (CBF) after TBI and correlated changes with clinical outcome. We analyzed magnetic resonance imaging scans from adult participants with TBI requiring hospitalization in the acute (2 weeks post-injury,  = 33) and chronic (6 months post-injury,  = 16) phases, with 13 participants scanned longitudinally at both time points. Read More

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Establishing a reference focal plane using beads for trypan-blue-based viability measurements.

J Microsc 2021 Jun 11. Epub 2021 Jun 11.

National Institute of Standards and Technology, Gaithersburg, MD, USA.

Trypan blue dye exclusion-based cell viability measurements are highly dependent upon image quality and consistency. In order to make measurements repeatable, one must be able to reliably capture images at a consistent focal plane, and with signal-to-noise ratio within appropriate limits to support proper execution of image analysis routines. Imaging chambers and imaging systems used for trypan blue analysis can be inconsistent or can drift over time, leading to a need to assure the acquisition of images prior to automated image analysis. Read More

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Relationship between autoimmune thyroid disease and nephropathy: A clinicopathological study.

Medicine (Baltimore) 2021 Jun;100(23):e26273

Department of Pathology, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.

Abstract: The association of nephropathy with autoimmune thyroid disease (AITD) has been reported previously. However, there is limited information on the relationship between thyroid autoantibodies and nephropathy. A retrospective study was conducted using the medical records of 246 patients with nephropathy, 82 of whom had concurrent AITD. Read More

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Role of multiparametric ultrasound in testicular focal lesions and diffuse pathology evaluation, with particular regard to elastography: review of Literature.

Andrology 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Background: Ultrasound is the main requested technique for the assessment of traumatic, vascular, neoplastic, and inflammatory testicular pathology. Moreover, the role of ultrasound has broadened over the years along with the introduction of new techniques, such as contrast enhanced ultrasound (CEUS) and US-elastography.

Objective: An updated representation of the pre-existing Literature evidence for multiparametric ultrasound imaging with particular regard to elastography, in the evaluation of focal and diffuse testicular pathologies, has been presented. Read More

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The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model.

J Biomed Mater Res B Appl Biomater 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

There is a need for the development of effective treatments for focal articular cartilage injuries. We previously developed a multiphasic 3D-bioplotted osteochondral scaffold design that can drive site-specific tissue formation when seeded with adipose-derived stem cells (ASC). The objective of this study was to evaluate this scaffold in a large animal model. Read More

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Inhibition of TMPRSS4 mediated epithelial-mesenchymal transition is critically involved in antimetastatic effect of melatonin in colorectal cancers.

Phytother Res 2021 Jun 11. Epub 2021 Jun 11.

College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

In the current study, the underlying anti-metastatic mechanism of melatonin contained in some edible plants was explored in association with transmembrane protease serine 4 (TMPRSS4) mediated metastasis and epithelial-mesenchymal transition (EMT) signaling in human HCT15 and SW620 colorectal cancer cells. Here, TMPRSS4 was highly expressed in HCT15, but was weakly expressed in SW620 cells. Melatonin exerted weak cytotoxicity, decreased invasion, adhesion, and migration, and attenuated the expression of TMPRSS4, cyclin E, pro-urokinase-type plasminogen activator (pro-uPA), p-signal transducer and activator of transcription 3 (p-STAT3), p-focal adhesion kinase (p-FAK), Snail and increased the expression of E-cadherin, p27, pp38 and p-Jun N-terminal kinases (p-JNK) in HCT15 cells. Read More

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Optogenetic model reveals cell shape regulation through FAK and Fascin.

J Cell Sci 2021 Jun 11. Epub 2021 Jun 11.

Departments of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell shape regulation is important but the mechanisms that govern shape are not fully understood, in part due to limited experimental models where cell shape changes and underlying molecular processes can be rapidly and non-invasively monitored in real time. Here, we use an optogenetic tool to activate RhoA in the middle of mononucleated macrophages to induce contraction, resulting in a side with the nucleus that retains its shape and a non-nucleated side which was unable to maintain its shape and collapsed. In cells overexpressing focal adhesion kinase (FAK), the non-nucleated side exhibited a wide flat morphology and was similar in adhesion area to the nucleated side. Read More

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KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum.

Brain 2021 Jun 11. Epub 2021 Jun 11.

Pediatric Neurology Department, Lyon University Hospital, 69500 Bron, France.

Variants in KCNT1, encoding a sodium-gated potassium channel (subfamily T member 1), have been associated with a spectrum of epilepsies and neurodevelopmental disorders. These range from familial autosomal dominant or sporadic sleep-related hypermotor epilepsy ((AD)SHE) to epilepsy of infancy with migrating focal seizures (EIMFS) and include developmental and epileptic encephalopathies (DEE). This study aims to provide a comprehensive overview of the phenotypic and genotypic spectrum of KCNT1 mutation-related epileptic disorders in 248 individuals, including 66 unpreviously published and 182 published cases, the largest cohort reported so far. Read More

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Mosaic RASopathy due to KRAS variant G12D with segmental overgrowth and associated peripheral vascular malformations.

Am J Med Genet A 2021 Jun 11. Epub 2021 Jun 11.

Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany.

Oncogenic RAS variants lead to constitutive overactivation and increased signal transduction into downstream pathways. They are found as somatic driver events in various types of human cancer. In a somatic mosaic status, the same RAS variants have been associated with a wide spectrum of focal or segmental tissue dysplasia and overgrowth including various types of congenital nevi, vascular malformations, and other changes (mosaic RASopathies). Read More

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Long-term cognitive and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiotherapy.

Pediatr Blood Cancer 2021 Jun 11:e29125. Epub 2021 Jun 11.

Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.

Background: Proton radiotherapy (PRT) may be associated with less neurocognitive risk than photon RT (XRT) for pediatric brain tumor survivors. We compared neurocognitive and academic outcomes in long-term survivors treated with XRT versus PRT.

Methods: Survivors underwent neurocognitive evaluation >1 year after craniospinal (CSI) or focal PRT or XRT. Read More

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WFUMB position paper. Incidental findings of the salivary glands.

Med Ultrason 2021 Jun 8. Epub 2021 Jun 8.

Department Allgemeine Innere Medizin (DAIM) Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland.

A salivary incidentaloma (SI) stands for any focal salivary lesion, independent of size, discovered by any imaging method including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), multimodal positron emis-sion tomography (PET) combined with CT or MRI, or X-ray imaging, performed for another reason, in the absence of known salivary glands' disease. The article presents a detailed analysis of salivary gland diseases with the emphasis on neoplasms. It describes frequency of SIs found on imaging, their prevalence, epidemiology and clinical significance. Read More

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Silent embolism of a large thrombus in transit through the patent foramen ovale: a case report.

Eur Heart J Case Rep 2021 Mar 31;5(3):ytab091. Epub 2021 Mar 31.

Cardiovascular Department, Saint Elizabeth's Medical Center, 736 Cambridge Street, Brighton, MA 02135, USA.

Background : Detection of a thrombus in transit through a patent foramen ovale (PFO) is extremely rare due to the transient nature of the process. We report an unusual case of a large, paradoxical embolus in transit seen on echocardiography through a PFO that was not found upon atriotomy.

Case Summary : An 80-year-old woman presented to the emergency room with shortness of breath and right leg pain. Read More

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A case report of takotsubo syndrome complicated by ischaemic stroke: the clinical dilemma of anticoagulation.

Eur Heart J Case Rep 2021 Mar 15;5(3):ytab051. Epub 2021 Mar 15.

Cardiothoracic and Vascular Department, Cardiology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Heart Tower-Room 807, Largo Città d'Ippocrate, 84131 Salerno, Italy.

Background: Takotsubo syndrome (TTS) is an acute and transient heart failure syndrome due to reversible myocardial dysfunction characterized by a wide spectrum of possible clinical scenarios. About one-fifth of TTS patients experience adverse in-hospital events. Thromboembolic complications, especially stroke, have been reported, albeit in a minority of patients. Read More

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ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.

Onco Targets Ther 2021 3;14:3583-3596. Epub 2021 Jun 3.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Integrin alpha 2 (ITGA2) is highly expressed in various cancers. ITGA2 up regulation promotes tumor proliferation, invasion, migration, and angiogenesis and ITGA2 is a poor prognostic factor in many tumors. However, the mechanism underlying its role in esophageal squamous cell carcinoma (ESCC) is unknown. Read More

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How to Assess Breathlessness in Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1581-1598. Epub 2021 Jun 3.

Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

Activity-related breathlessness is the most problematic symptom of chronic obstructive pulmonary disease (COPD), arising from complex interactions between peripheral pathophysiology (both pulmonary and non-pulmonary) and central perceptual processing. To capture information on the breathlessness experienced by people with COPD, many different instruments exist, which vary in applicability depending on the purpose and context of assessment. We reviewed common breathlessness assessment instruments, providing recommendations around how to assess the severity of, or change in, breathlessness in people with COPD in daily life or in response to exercise provocation. Read More

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HGK promotes metastatic dissemination in prostate cancer.

Sci Rep 2021 Jun 10;11(1):12287. Epub 2021 Jun 10.

Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia , Universidad Complutense de Madrid, Ciudad Universitaria , Madrid, Spain.

Metastasis is the process of cancer cell dissemination from primary tumors to different organs being the bone the preferred site for metastatic homing of prostate cancer (PCa) cells. Prostate tumorigenesis is a multi-stage process that ultimately tends to advance to become metastatic PCa. Once PCa patients develop skeletal metastases, they eventually succumb to the disease. Read More

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The One-Bone Forearm in Children: Surgical Technique and a Retrospective Review of Outcomes.

J Hand Surg Am 2021 Jun 7. Epub 2021 Jun 7.

Department of Orthopedic Surgery, Shriners Hospitals for Children, Philadelphia, PA.

Purpose: The purpose of this study was to describe a technique of end-to-end rigid fixation of the distal radius to the proximal ulna. The shortening and radioulnar overlap in this technique yield a high union rate, large corrections, and few complications.

Methods: This retrospective chart review from 2 centers was undertaken in 39 patients (40 forearms) who underwent one-bone forearm operations between 2005 and 2019. Read More

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