2,568 results match your criteria Focal Nodular Hyperplasia


Hepatic Focal Nodular Hyperplasia.

Mayo Clin Proc 2020 Jul;95(7):1557-1558

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2020.05.021DOI Listing

Benign Neoplasms, Mass-Like Infections, and Pseudotumors That Mimic Hepatic Malignancy at MRI.

J Magn Reson Imaging 2020 Jul 4. Epub 2020 Jul 4.

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, Women's College Hospital, and University of Toronto, Toronto, Ontario, Canada.

A variety of conditions may mimic hepatic malignancy at MRI. These include benign hepatic tumors and tumor-like entities such as focal nodular hyperplasia-like lesions, hepatocellular adenoma, hepatic infections, inflammatory pseudotumor, vascular entities, and in the cirrhotic liver, confluent fibrosis, and hypertrophic pseudomass. These conditions demonstrate MRI features that overlap with hepatic malignancy, and can be challenging for radiologists to diagnose accurately. Read More

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http://dx.doi.org/10.1002/jmri.27251DOI Listing

Focal Nodular Hyperplasia and Hepatic Adenoma: Evaluation and Management.

Clin Liver Dis 2020 Aug 3;24(3):389-403. Epub 2020 Jun 3.

Division of Gastroenterology and Hepatology, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, MNP 4112, Portland, OR 97239, USA.

Focal nodular hyperplasia and hepatocellular adenoma are benign liver lesions that occur most frequently in women and may be found as incidental findings on imaging. hepatocellular adenomas may be infrequently associated with malignant progression or risk of rupture and as such, require surveillance or definitive treatments based on their size threshold. It is important clinically to differentiate these lesions, and utilizing imaging modalities such as contrast enhanced ultrasound or magnetic resonance imaging can be helpful in diagnosis. Read More

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http://dx.doi.org/10.1016/j.cld.2020.04.013DOI Listing

A rare case of peliosis hepatis in primary immune deficiency.

SAGE Open Med Case Rep 2020 17;8:2050313X20931996. Epub 2020 Jun 17.

Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Peliosis hepatis is a rare condition characterized by blackish-blue blood-filled cavities in hepatic parenchyma caused by dilatation of hepatic sinusoids. Peliosis hepatis has been described in secondary immunodeficiencies and certain medications. We present the first case of peliosis hepatis in a patient with a primary immunodeficiency, common variable immunodeficiency. Read More

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http://dx.doi.org/10.1177/2050313X20931996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301656PMC

Validation study of perfusion parameter in hypervascular hepatocellular carcinoma and focal nodular hyperplasia using dynamic susceptibility magnetic resonance imaging with super-paramagnetic iron oxide: comparison with single level dynamic CT arteriography.

Quant Imaging Med Surg 2020 Jun;10(6):1298-1306

Department of Radiology, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Background: Dynamic susceptibility contrast MR imaging (DSC-MRI) offers direct evaluation of neo-vascularity. Ferucarbotran does not accumulate in the interstitial space, instead remaining in the intravascular space during early phase imaging. We investigate tracer kinetic analysis with DSC-MRI with ferucarbotran and single level CT during hepatic arteriography (SL-CTHA) in assessment of hypervascular hepatocellular lesions and evaluate the usefulness of DSC-MRI with ferucarbotran. Read More

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http://dx.doi.org/10.21037/qims-18-233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276367PMC

A Shifting Paradigm in Diagnosis and Management of Hepatic Adenoma.

Ann Surg Oncol 2020 Jun 15. Epub 2020 Jun 15.

Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: New insights into molecular pathogenesis of hepatocellular adenomas (HCA) have allowed sub-classification based on distinct genetic alterations and a fresh look at characterizations of natural history. Clinically, this is important in understanding risk factors for two feared complications: malignant transformation and hemorrhage.

Methods: PubMed literature search for hepatocellular adenoma over all years, excluding case reports and articles focusing on multiple adenomas or adenomatosis. Read More

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http://dx.doi.org/10.1245/s10434-020-08580-wDOI Listing

An Uncommon Focal Liver Lesion: Intrahepatic Splenosis.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):257-262. Epub 2020 Jun 3.

Unit of Internal Medicine, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola- Malpighi, Bologna.

Multiple focal liver lesions were incidentally detected in a patient screened by ultrasound for a recent diagnosis of lower limb deep vein thrombosis, for which anticoagulation had been initiated. Past medical history reported a post-traumatic splenectomy 15 years before. Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) showed a subcapsular lesion in liver segment 5 consistent with focal nodular hyperplasia (FNH) and multiple other nodules, with a different pattern from the former, judged as probable hepatic adenomas by MRI but probable hemangiomas by CEUS (hyperenhancement in the late phase). Read More

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http://dx.doi.org/10.15403/jgld-617DOI Listing

Acute abdomen caused by a large pedunculated pediculated focal nodular hyperplasia of the liver.

Dig Liver Dis 2020 Jun 8. Epub 2020 Jun 8.

Universidade de Passo Fundo Faculdade de Medicina, Brazil.

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http://dx.doi.org/10.1016/j.dld.2020.05.009DOI Listing

Hepatocyte specific contrast enhanced MRI findings of focal nodular hyperplasia like nodules in liver following chemotherapy in pediatric cancer patients.

Diagn Interv Radiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey.

Purpose: We aimed to assess the MRI findings and follow-up of multiple focal nodular hyperplasia (FNH)- like lesions in pediatric cancer patients diagnosed by imaging findings.

Methods: We retrospectively analyzed clinical data and MRI examinations of 16 pediatric patients, who had been scanned using gadoxetate disodium (n=13) and gadobenate dimeglumine (n=3). Hepatic nodules were reviewed according to their number, size, contour, T1- and T2-weighted signal intensities, arterial, portal, delayed and hepatobiliary phase enhancement patterns. Read More

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http://dx.doi.org/10.5152/dir.2019.19398DOI Listing

Focal nodular marrow hyperplasia: Imaging features of 53 cases.

Br J Radiol 2020 Jun 3:20200206. Epub 2020 Jun 3.

Department of Medical Imaging, Royal National Orthopaedic Hospital, Brockley Hill Stanmore, UK.

Objective: To describe the characteristic imaging features of focal nodular marrow hyperplasia (FNMH).

Methods And Materials: Retrospective review of all patients with a diagnosis of FNMH between January 2007 and September 2019.

Results: The study included 53 patients, 7 males and 46 females with a mean age of 58 years (range 12-95 years). Read More

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http://dx.doi.org/10.1259/bjr.20200206DOI Listing

LI-RADS to categorize liver nodules in patients at risk of HCC: tool or a gadget in daily practice?

Radiol Med 2020 May 26. Epub 2020 May 26.

Operative Unit of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan University, Via Francesco Sforza, 35, 20122, Milan, Italy.

Purpose: To determine the effectiveness of liver reporting and data system (LI-RADS) to diagnose hepatocellular carcinoma (HCC) and to retrospectively evaluate its impact on the adopted therapeutic strategy.

Materials And Methods: Preoperative imaging of 40 of 350 patients (median age 66, 31 M/9 F) submitted to liver resection for suspected HCC, between January 2008 and August 2019, has been retrospectively analyzed by two radiologists with different expertise, according to CT/MRI LI-RADS v2018, both blinded to clinical and pathological results and untrained to using aforementioned scoring system.

Results: The perfect agreement between the readers was about 62. Read More

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http://dx.doi.org/10.1007/s11547-020-01225-8DOI Listing
May 2020
1.368 Impact Factor

Benign Hepatic Tumors: From Incidental Imaging Finding to Clinical Management.

Korean J Fam Med 2020 May 27. Epub 2020 May 27.

Gastroenterology and Hepatology Institute, Hillel Yaffe Medical Center, Hadera, Israel.

Benign hepatic tumors (BHTs) are commonly detected as incidental finding mainly due to the frequent utilization of imaging modalities, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Rigorous clinical evaluation, with a particular focus on chronic liver disease (CLD) or risk factors for CLD, medication history, physical examination for signs of CLD, blood tests, and a review of past liver radiology constitute the initial steps in the evaluation of a new liver lesion. Further, contrast-enhanced imaging using US, CT and MRI, can be used depending on the clinical scenario and their availability. Read More

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http://dx.doi.org/10.4082/kjfm.18.0188DOI Listing

Hepatobiliary MR contrast agents are useful to diagnose hepatocellular carcinoma in patients with Budd-Chiari syndrome.

JHEP Rep 2020 Jun 9;2(3):100097. Epub 2020 Mar 9.

Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, France.

Background & Aims: Hepatobiliary phase (HBP) images can discriminate between benign and malignant liver lesions, but it is unclear if this approach can be used in patients with Budd-Chiari syndrome (BCS). Thus, we aimed to assess the diagnostic utility of HBP images in patients with BCS.

Methods: This retrospective study included all patients admitted to our institution with a diagnosis of BCS and focal liver lesions on hepatobiliary contrast agent-enhanced MR imaging (HBCA-MRI) from 2000 to 2019. Read More

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http://dx.doi.org/10.1016/j.jhepr.2020.100097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232085PMC

Two cases of benign hepatic nodules caused by sinusoidal dilatation with different hemodynamics.

Clin J Gastroenterol 2020 May 16. Epub 2020 May 16.

Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

We describe two cases of benign nodules caused by sinusoidal dilatation with different hemodynamic statuses. Case 1 was a 50-year-old woman with a 1-cm nodule that showed a low density in the arterial phase of computed tomography. Pathologically, there were no atypical cells with sinusoidal dilatation, and immunostaining was negative for CD34. Read More

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http://dx.doi.org/10.1007/s12328-020-01129-0DOI Listing

Echinococcus multilocularis: Diagnostic problem in a liver core biopsy.

Cesk Patol 2020 ;56(1):32-34

Echinococcus multilocularis causes an aggressive form of hydatidosis whose histomorphological picture is generally not well recognized. We report a case of 39-year-old women presenting with poorly circumscribed nodules in the right hepatic lobe. Owing to the clinical suspicion of focal nodular hyperplasia and hepatocellular adenoma, a core biopsy was performed. Read More

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January 2020

[Genetic changes and biological potential of proliferative nodule in congenital pigmented nevus].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):458-463

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

To study the genetic changes and biological potential of proliferative nodule in congenital melanocytic nevus. Whole-exome sequencing was carried out using the technique of next-generation sequencing (NGS) in order to detect the genomic alterations of two cases of proliferative nodules (PN) in congenital melanocytic nevi (CMN). Twelve cases of CMN and ten cases of malignant melanoma were used as benign and malignant controls, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190905-00485DOI Listing

Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report.

Surg Case Rep 2020 May 7;6(1):94. Epub 2020 May 7.

Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma, 371-8511, Japan.

Background: Hepatocellular adenoma (HCA) is conventionally considered a rare benign liver tumor, but advanced studies have revealed that HCA is heterogeneous, and may include a type that is prone to malignant transformations. Differentiation between well-differentiated hepatocellular carcinoma and focal nodular hyperplasia is necessary to diagnose hepatocellular adenoma through imaging; however, the tumor marker of hepatocellular carcinoma, protein induced by vitamin K absence, or antagonist II (PIVKA-II), is rarely positive in hepatocellular adenoma.

Case Presentation: A 44-year-old woman presented to our hospital with complaints of loss of appetite and weight loss. Read More

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http://dx.doi.org/10.1186/s40792-020-00853-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205962PMC

Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls.

Abdom Radiol (NY) 2020 May 6. Epub 2020 May 6.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.

This essay aimed to illustrate the various hepatic nodules that may exhibit arterial phase hyperenhancement and washout on computed tomography/magnetic resonance imaging (CT/MRI). Hepatic nodules with arterial phase hyperenhancement and washout on CT/MRI include hepatocellular carcinoma, focal nodular hyperplasia-like nodules, serum amyloid A-positive hepatocellular neoplasms, intrahepatic cholangiocarcinoma, intrahepatic bile duct adenoma, hepatoblastoma, hepatocellular adenoma, hepatic epithelioid angiomyolipoma, and metastasis including neuroendocrine and gastrointestinal stromal tumors. Understanding the imaging findings is important to ensure correct diagnosis. Read More

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http://dx.doi.org/10.1007/s00261-020-02560-0DOI Listing

Role of real-time shear-wave elastogarphy in differentiating hepatocellular carcinoma from other hepatic focal lesions.

Eur J Gastroenterol Hepatol 2020 Apr 27. Epub 2020 Apr 27.

Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine Benha University.

Background: Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and is considered the second cause of cancer-related death.

Aim: The aim of the study is to assess the usefulness of real-time shear-wave elastography in differentiating HCC from other hepatic focal lesions.

Patients And Methods: The current study was conducted on 110 patients in addition to 10 healthy subjects, divided into four groups as follows: liver cirrhosis, HCC, hepatic focal lesions other than HCC, and control. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001741DOI Listing

Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy.

Arch Pathol Lab Med 2020 Apr 27. Epub 2020 Apr 27.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Immune checkpoint inhibitors (CPIs), including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors and the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors, are being increasingly used for treating many advanced malignancies. However, CPI therapy is also associated with gastrointestinal and hepatobiliary adverse effects. Read More

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http://dx.doi.org/10.5858/arpa.2020-0070-RADOI Listing

Quantification of liver fat content in liver and primary liver lesions using triple-echo-gradient-echo MRI.

Eur Radiol 2020 Apr 22. Epub 2020 Apr 22.

Department of Diagnostic and Interventional Radiology, St-Eloi University Hospital, Montpellier, France.

Objectives: To quantify and compare the fat fraction of background liver and primary liver lesions using a triple-echo-gradient-echo sequence. M&M: This IRB-approved study included 128 consecutive patients who underwent a liver MRI for lesion characterization. Fat fraction from the whole lesion volume and the normal liver parenchyma were computed from triple-echo (consecutive in-phase, opposed-phase, in-phase echo times) sequence. Read More

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http://dx.doi.org/10.1007/s00330-020-06757-1DOI Listing

Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions.

J Endocrinol Invest 2020 Apr 2. Epub 2020 Apr 2.

Department of General Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Aim: A reticulin staining pattern (RSP) can be used for the differential diagnosis of endocrine gland lesions, as in the adrenal and hypophysis glands. We aimed to use RSP for the differential diagnosis of parathyroid gland lesions.

Materials And Methods: In this study, we evaluated 97 parathyroid lesions in 85 patients, as well as 29 normal parathyroid glands. Read More

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http://dx.doi.org/10.1007/s40618-020-01239-zDOI Listing

Inflammatory hepatocellular adenoma, focal nodular hyperplasia and hepatic granulomas in one single patient : possible physiopathologic explanations.

Acta Gastroenterol Belg 2020 Jan-Mar;83(1):83-85

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

We report the case of a hepatocellular adenoma associated with focal nodular hyperplasia and hepatic granulomas in a 30-yearsold woman. This association has rarely been described before but might be explained by underlying common pathophysiologic mechanisms. In this manuscript possible links between the three entities are discussed. Read More

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Regenerative hepatic pseudotumor: a new pseudotumor of the liver.

Hum Pathol 2020 May 25;99:43-52. Epub 2020 Mar 25.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, USA, 55905.

Cases of new pseudotumors of the liver were collected from multiple medical centers. Four resection and 4 biopsy specimens were collected, including 4 women and 4 men at an average age of 48 ± 15 years (range: 28-73 years). The lesions were visible on imaging but were either ill-defined or had indeterminate features for characterization. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.03.010DOI Listing

Spectrum of Hepatic Manifestations of Common Variable Immunodeficiency.

Am J Surg Pathol 2020 May;44(5):617-625

Department of Pathology.

Common variable immunodeficiency (CVID) has a heterogenous clinical presentation and can be challenging to diagnose. Distinct histologic changes have been linked with CVID in several organ systems, which can help identify the correct diagnosis. In this study we review a cohort of hepatic CVID biopsies, to better define the spectrum of histologic and biochemical alterations. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001452DOI Listing

Characterization of Indeterminate Liver Lesions on CT and MRI With Contrast-Enhanced Ultrasound: What Is the Evidence?

AJR Am J Roentgenol 2020 06 17;214(6):1295-1304. Epub 2020 Mar 17.

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 585 University Ave, Toronto, ON M5G 2N2, Canada.

CT or MRI is most commonly used for characterizing focal hepatic lesions. However, findings on CT and MRI are occasionally indeterminate. Contrast-enhanced ultrasound (CEUS), with its unique characteristics as a purely intravascular contrast agent and real-time evaluation of enhancement, is a useful next step. Read More

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http://dx.doi.org/10.2214/AJR.19.21498DOI Listing

Differential Diagnosis of Atypical Hepatocellular Carcinoma in Contrast-Enhanced Ultrasound Using Spatio-Temporal Diagnostic Semantics.

IEEE J Biomed Health Inform 2020 Mar 3. Epub 2020 Mar 3.

Atypical Hepatocellular Carcinoma (HCC) is very hard to distinguish from Focal Nodular Hyperplasia (FNH) in routine imaging. However little attention was paid to this problem. This paper proposes a novel liver tumor Computer-Aided Diagnostic (CAD) approach extracting spatio-temporal semantics for atypical HCC. Read More

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http://dx.doi.org/10.1109/JBHI.2020.2977937DOI Listing

A Review of Benign Hepatic Tumors and Their Imaging Characteristics.

Cureus 2020 Jan 29;12(1):e6813. Epub 2020 Jan 29.

Radiology, AdventHealth Orlando, Orlando, USA.

This paper concisely reviews the benign hepatic tumors most commonly encountered by clinicians. It includes the epidemiology, pathology, and imaging characteristics of hepatic hemangiomas, focal nodular hyperplasia (FNH), and hepatic adenomas (HAs). Read More

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http://dx.doi.org/10.7759/cureus.6813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047931PMC
January 2020

Imaging Features of Fibrolamellar Hepatocellular Carcinoma with Contrast-Enhanced Ultrasound.

Ultraschall Med 2020 Feb 26. Epub 2020 Feb 26.

Department Allgemeine Innere Medizin, Kliniken Hirslanden Beau Site, Salem und Permanence, Switzerland.

Purpose:  Fibrolamellar hepatocellular carcinoma (f-HCC) is a rare primary liver tumor. Imaging plays an important role in diagnosis. The aim of this retrospective study was to analyze contrast-enhanced ultrasound (CEUS) features of histologically proven f-HCC in comparison to benign focal nodular hyperplasia (FNH). Read More

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http://dx.doi.org/10.1055/a-1110-7124DOI Listing
February 2020
4.924 Impact Factor

A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver.

Cancer Imaging 2020 Feb 24;20(1):20. Epub 2020 Feb 24.

Department of Radiology, the Affiliated Hospital of Qingdao University, No.16, Jiangsu Road, Qingdao, 266000, Shandong, China.

Background: The purpose of this study was to develop and validate a radiomics nomogram for preoperative differentiating focal nodular hyperplasia (FNH) from hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

Methods: A total of 156 patients with FNH (n = 55) and HCC (n = 101) were divided into a training set (n = 119) and a validation set (n = 37). Radiomics features were extracted from triphasic contrast CT images. Read More

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http://dx.doi.org/10.1186/s40644-020-00297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041197PMC
February 2020

Near-Complete Disappearance of a Giant Focal Nodular Hyperplasia in the Liver.

Clin Gastroenterol Hepatol 2020 Feb 14. Epub 2020 Feb 14.

Hospital Alemán, Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.cgh.2020.02.016DOI Listing
February 2020

Management of focal nodular hyperplasia of the liver: Experience of 50 pediatric patients in a tertiary center.

J Pediatr Surg 2020 Jan 29. Epub 2020 Jan 29.

Department of Pediatric Surgery, Hôpitaux Universitaires Paris-Sud (AP-HP), Hôpital Bicêtre, 78, avenue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France. Electronic address:

Background: Focal nodular hyperplasia (FNH) is a rare benign hepatic lesion in children. No management guidelines for pediatric population exist because of limited evidence.

Objective: To review the experience of a large tertiary liver center, providing additional clinical data to help formulate management guidelines for FNH in the pediatric population. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.01.009DOI Listing
January 2020

Reply to "Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia".

J Magn Reson Imaging 2020 Feb 5. Epub 2020 Feb 5.

Department of Radiology, APHP, HU Henri Mondor, Creteil, France.

Level Of Evidence: 5 TECHNICAL EFFICACY STAGE: 3 CONFLICT OF INTEREST: None.

Financial Support: None. Read More

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http://dx.doi.org/10.1002/jmri.27074DOI Listing
February 2020

State-of-the-art MR Imaging of Fat-containing Focal Lesions of the Liver.

Curr Med Imaging Rev 2019 ;15(5):435-442

Department of Radiology I, Maria Skłodowska-Curie Memorial Cancer Centre, Institute of Oncology, Ul. Roentgena 5, 02-781 Warszawa, Poland.

Background: Fat can be identified in numerous liver lesions, and usually is not a specific finding. Distinguishing between different kinds of fatty deposits is an important part of differential diagnosis. Magnetic Resonance Imaging (MRI) is superior to other imaging techniques because it allows distinguishing intracellular from macroscopic fat. Read More

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http://dx.doi.org/10.2174/1573405614666171218154838DOI Listing
January 2019

Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.

Eur Radiol 2020 May 30;30(5):2995-3003. Epub 2020 Jan 30.

CHU de Bordeaux, Service d'imagerie diagnostique et Interventionnelle Magellan/Saint André, F-33000, Bordeaux, France.

Objective: A new computer tool is proposed to distinguish between focal nodular hyperplasia (FNH) and an inflammatory hepatocellular adenoma (I-HCA) using contrast-enhanced ultrasound (CEUS). The new method was compared with the usual qualitative analysis.

Methods: The proposed tool embeds an "optical flow" algorithm, designed to mimic the human visual perception of object transport in image series, to quantitatively analyse apparent microbubble transport parameters visible on CEUS. Read More

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http://dx.doi.org/10.1007/s00330-019-06566-1DOI Listing

Application of new ultrasound techniques for focal liver lesions.

J Med Ultrason (2001) 2020 Apr 16;47(2):215-237. Epub 2020 Jan 16.

Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Ultrasonography (US) has the overwhelming advantages of not entailing radiation exposure and being a noninvasive, real-time, convenient, easy-to-perform, and relatively inexpensive imaging modality. It is used as the first-line imaging modality for screening, detection, and diagnosis of focal liver lesions (FLLs) [small hepatocellular carcinomas (HCCs), in particular]. However, with the increasing demand for accurate and early diagnosis of small HCCs, newer radiologic methods need to be explored to overcome certain limitations of US. Read More

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http://dx.doi.org/10.1007/s10396-019-01001-wDOI Listing

[Management of benign liver tumors].

Internist (Berl) 2020 Feb;61(2):140-146

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Benign liver tumors form a heterogeneous group. The most frequent forms include simple cysts, hemangiomas, focal nodular hyperplasia and hepatocellular adenomas. They are often incidentally detected during routine sonography. Read More

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http://dx.doi.org/10.1007/s00108-019-00736-5DOI Listing
February 2020

[Sonographic diagnostics of liver tumors].

Internist (Berl) 2020 Feb;61(2):115-122

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Liver tumors are often incidentally found during ultrasound examinations. The decision on further diagnostic imaging depends on the clinical context and the appearance in B mode ultrasound. This review highlights the role of grey scale and contrast-enhanced ultrasound (CEUS) and summarizes the ultrasonographic key features of the most common benign and malignant liver tumors. Read More

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http://dx.doi.org/10.1007/s00108-019-00728-5DOI Listing
February 2020

The incidence of skip metastases on whole bone MRI in high-grade bone sarcomas.

Skeletal Radiol 2020 Jun 9;49(6):945-954. Epub 2020 Jan 9.

Department of Imaging, Royal National Orthopaedic Hospital, Stanmore, UK.

Introduction: Skip metastases have been described with osteosarcoma, Ewing sarcoma and rarely chondrosarcoma. The aim of this study was to determine the incidence of skip metastases on whole bone MRI in all primary high-grade sarcomas of the major long bones.

Materials And Method: Retrospective review of patients from April 2007 to April 2019 with high-grade primary bone sarcomas of the humerus, radius, ulna, femur, tibia or fibula who had whole bone MRI at initial staging. Read More

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http://dx.doi.org/10.1007/s00256-019-03369-9DOI Listing

[Radiological diagnostic workup of liver tumors].

Authors:
H-J Raatschen

Internist (Berl) 2020 Feb;61(2):123-130

Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

The imaging of focal liver lesions is a common task in daily radiological routine. The objectives of diagnostic imaging are, in addition to lesion detection, the characterization of the lesion as well as the follow-up assessment after surgical or local treatment or under systemic therapy. This article presents the typical morphologies observed in computed tomography and magnetic resonance imaging of hepatocellular carcinomas and intrahepatic cholangiocarcinomas as the most important representatives of primary malignant liver tumors and juxtaposes them with benign primary liver lesions such as adenoma and focal nodular hyperplasia (FNH). Read More

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http://dx.doi.org/10.1007/s00108-019-00724-9DOI Listing
February 2020

Characterization of the arterial enhancement pattern of focal liver lesions by multiple arterial phase magnetic resonance imaging: comparison between hepatocellular carcinoma and focal nodular hyperplasia.

Radiol Med 2020 Apr 8;125(4):348-355. Epub 2020 Jan 8.

Department of Surgical Sciences, Radiology Unit, University of Turin, Via Genova 3, 10126, Turin, Italy.

Purpose: To evaluate the features of arterial enhancement pattern of focal nodular hyperplasia (FNH) and hepatocellular carcinoma (HCC) by triple-phase arterial magnetic resonance imaging (MRI).

Methods: Data were retrospectively collected from 52 consecutive patients who underwent triple-phase arterial MRI using hepatocyte-specific contrast agents (Gd-EOB-DTPA) from January 2017 to October 2017, with a MR imaging diagnosis of HCC or FNH. The images were independently assessed by two blinded readers. Read More

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http://dx.doi.org/10.1007/s11547-019-01127-4DOI Listing

Abernethy malformation and hepatocellular carcinoma: a serious consequence of a rare disease.

BMJ Case Rep 2020 Jan 6;13(1). Epub 2020 Jan 6.

Centro Hepato-Bilio-Pancreático e de Transplantação, Hospital Curry Cabral, Lisboa, Portugal.

Congenital portosystemic shunts (CPSS) are a rare vascular consequence of embryogenetic vascular alterations or the persistence of the fetal circulation elements, first described by John Abernethy in 1793 and classified by Morgan and Superina, into complete and partial portosystemic shunts. Its prevalence to this day has not been defined. We present a patient series of a 44-year-old and 47-year-old man and woman, with this rare congenital malformation and underlining hepatocellular carcinoma (HCC) treatment strategies. Read More

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http://dx.doi.org/10.1136/bcr-2019-231843DOI Listing
January 2020

Multi-parameter ultrasound based on the logistic regression model in the differential diagnosis of hepatocellular adenoma and focal nodular hyperplasia.

World J Gastrointest Oncol 2019 Dec;11(12):1193-1205

Department of Ultrasound, Yinzhou Hospital Affiliated to Ningbo University School of Medicine, Ningbo 315000, Zhejiang Province, China.

Background: Focal nodular hyperplasia (FNH) has very low potential risk, and a tendency to spontaneously resolve. Hepatocellular adenoma (HCA) has a certain malignant tendency, and its prognosis is significantly different from FNH. Accurate identification of HCA and FNH is critical for clinical treatment. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i12.1193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937441PMC
December 2019

Hepatic focal nodular hyperplasia after pediatric hematopoietic stem cell transplantation: The impact of hormonal replacement therapy and iron overload.

Pediatr Blood Cancer 2020 04 30;67(4):e28137. Epub 2019 Dec 30.

Clinica Pediatrica, Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.

Background: The advent of techniques for the assessment of iron overload (liver T2*-MRI) has led to the awareness that focal nodular hyperplasia (FNH) represents a possible incidental finding after hematopoietic stem cell transplantation (HSCT), though its pathogenesis is still unclear.

Methods: We performed a retrospective analysis of the liver T2*-MRI scans performed between 2013 and 2018 in a single pediatric HSCT Unit and recorded the number of patients with FNH (group A). Patients incidentally diagnosed with FNH at imaging performed for different clinical indications were included in group B. Read More

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http://dx.doi.org/10.1002/pbc.28137DOI Listing

Hyperintense Liver Masses at Hepatobiliary Phase Gadoxetic Acid-enhanced MRI: Imaging Appearances and Clinical Importance.

Radiographics 2020 Jan-Feb;40(1):72-94. Epub 2019 Dec 13.

From the Departments of Clinical Radiology (N.F., A.N., K. Ishigami, Y.U., D.K., K.M., K. Ishimatsu, H.H.), Advanced Imaging and Interventional Radiology (Y.A.), and Molecular Imaging and Diagnosis (T.N.), Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Gadoxetic acid, a hepatobiliary-specific contrast medium used for MRI, is becoming increasingly important in the detection and characterization of hepatic mass lesions. This medium is taken up by functioning hepatocytes, and the liver parenchyma is strongly enhanced in the hepatobiliary phase (HBP), during which hepatic mass lesions without functioning hepatocytes commonly show hypointensity. However, some hepatic mass lesions show hyperintensity in the HBP. Read More

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http://dx.doi.org/10.1148/rg.2020190037DOI Listing
December 2019

A rare case of hepatocellular carcinoma arising from gadoxetate-retaining hepatic adenoma.

Radiol Case Rep 2020 Feb 27;15(2):141-143. Epub 2019 Nov 27.

Department of Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.

Hepatocellular adenomas (HCAs) are benign lesions of the liver which can rarely undergo malignant transformation. We report a 26-year-old woman with no underlying liver disease found to have an incidental liver lesion on noncontrast CT during workup for gastric reflux. Follow up MRI revealed a 10 cm gadoxetate-retaining lesion within the right hepatic lobe with imaging features suggestive of HCA vs focal nodular hyperplasia . Read More

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http://dx.doi.org/10.1016/j.radcr.2019.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889246PMC
February 2020

An elderly man with progressive focal nodular hyperplasia.

Clin J Gastroenterol 2020 Jun 25;13(3):413-420. Epub 2019 Nov 25.

Department of Pathology, Teikyo University Hospital, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8606, Japan.

Patients with focal nodular hyperplasia (FNH) develop benign hepatocellular nodules. FNH most frequently occurs in young women. There are no reports of the onset of FNH in elderly men. Read More

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http://dx.doi.org/10.1007/s12328-019-01072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239834PMC

[Unknown liver lesions].

Dtsch Med Wochenschr 2019 11 21;144(23):1651-1664. Epub 2019 Nov 21.

Unknown liver lesions represent a common clinical challenge, for example in the context of routine ultrasound examinations of primary care physicians. There are different data on the prevalence of primary liver lesions in the literature. As such, a forensic autopsy series described focal liver lesions in about 50 % of all examined men between 35 and 69 years of age with an increasing incidence for older people. Read More

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http://dx.doi.org/10.1055/a-0733-6122DOI Listing
November 2019
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