55,348 results match your criteria Fluorouracil Toxicity and DPYD


Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells.

J Cancer Res Ther 2018 Dec;14(Supplement):S1141-S1147

Department of General Surgery, Institute of General Surgery, General Hospital, Tianjin Medical University, Tianjin, P.R. China.

Aim Of Study: The roles of autophagy performed in chemotherapy-induced cell death or proliferation inhibition were still in debate. In this study, we aimed to disclose the function of autophagy in chemotherapy of HCT-116 colon cells.

Materials And Methods: Pharmacological and genetic methods were applied to induce and inhibit autophagy and elucidate the roles of autophagy performed in chemotherapy-induced proliferation inhibition and apoptosis. Read More

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December 2018

Value of plasma SN-38 levels and DPD activity in irinotecan-based individualized chemotherapy for advanced colorectal cancer with heterozygous type UGT1A16 or UGT1A128.

Cancer Manag Res 2018 22;10:6217-6226. Epub 2018 Nov 22.

Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, People's Republic of China,

Purpose: The relationship between the pharmacokinetics of irinotecan and outcomes of advanced colorectal cancer is unclear, and few studies have examined individualized irinotecan-based chemotherapy depending on plasma 7-ethyl-10-hydroxy camptothecin (SN-38) levels and dihydropyrimidine dehydrogenase (DPD) activity, particularly for the UGT1A16 or UGT1A128 heterozygous type.

Methods: This study retrospectively explored the relationship among plasma SN-38 level 1.5 hours after critical enzyme for irinotecan (CPT-11) administration (C), plasma SN-38 level 49 hours after CPT-11 administration (C), DPD activity, and clinical outcomes for the UGT1A16 and UGT1A128 heterozygous types. Read More

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November 2018

Upregulation of KIF20A correlates with poor prognosis in gastric cancer.

Cancer Manag Res 2018 23;10:6205-6216. Epub 2018 Nov 23.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China,

Background: KIF20A is well known as one of the key proteins in mitosis. Recently, a number of studies illustrated that might function as an oncogene in some carcinomas. However, its expression levels and clinical value remained unclear in gastric cancer (GC). Read More

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November 2018

First-line chemotherapy regimens for locally advanced and metastatic pancreatic adenocarcinoma: a Bayesian analysis.

Cancer Manag Res 2018 20;10:5965-5978. Epub 2018 Nov 20.

Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,

Background: Systemic chemotherapy is the standard treatment for locally advanced and metastatic pancreatic cancer, but there is no consensus on the optimum regimen. We aimed to compare and rank the locally advanced and metastatic pancreatic adenocarcinoma chemotherapy regimens evaluated in randomized controlled trials (RCTs) in the past 15 years.

Materials And Methods: PubMed, Embase, Cochrane Collaboration database, and ClinicalTrials. Read More

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November 2018

Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake.

Onco Targets Ther 2018 23;11:8301-8307. Epub 2018 Nov 23.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,

Background: Oral fluoropyrimidine plus platinum is a standard first-line treatment for advanced gastric cancer (AGC). However, this treatment is problematic for AGC patients with massive ascites or inadequate oral intake. This study aimed at evaluating the efficacy and safety of modified oxaliplatin (L-OHP) with l-leucovorin (l-LV) and bolus/continuous infusion of 5-fluorouracil (5-FU) (mFOLFOX6) regimen for patients with massive ascites or inadequate oral intake. Read More

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November 2018

Bladder Invasion in Patients with Advanced Colorectal Carcinoma.

Indian J Surg Oncol 2018 Dec 23;9(4):547-551. Epub 2018 Jul 23.

5Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.

Involvement of the bladder by colorectal cancer is sufficiently rare to be encountered by an individual surgeon on an infrequent basis. Extirpative procedures for advanced colorectal cancers can involve partial/total bladder resections. In patients without evidence of distant metastatic disease, a reasonable therapeutic effect can be expected when negative surgical margins are obtained. Read More

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December 2018

FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance.

Cell Death Dis 2018 Dec 11;9(12):1185. Epub 2018 Dec 11.

Department of Surgery and Cancer, Imperial College London, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.

Fluorouracil (5-FU) is the first-line chemotherapeutic drug for cholangiocarcinoma (CCA), but its efficacy has been compromised by the development of resistance. Development of 5-FU resistance is associated with elevated expression of its cellular target, thymidylate synthase (TYMS). E2F1 transcription factor has previously been shown to modulate the expression of FOXM1 and TYMS. Read More

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December 2018

5-Fluorouracil-induced coronary thrombosis: A case report and review of the literature.

J Cardiol Cases 2012 Jul 13;6(1):e20-e22. Epub 2012 Apr 13.

Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI, USA.

5-Fluorouracil (5-FU) is a key component in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, this chemotherapeutic agent also possesses several associated cardiac toxicities, including coronary vasospasm and coronary thrombosis. We report a case of acute coronary syndrome with thrombotic subtotal coronary artery occlusion in the setting of home 5-FU infusion highlighting the importance of careful pre-administration cardiac evaluation and close monitoring during drug administration. Read More

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Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.

Arch Pharm (Weinheim) 2018 Dec 10:e1800192. Epub 2018 Dec 10.

Department of Chemistry, School of Chemical and Life Science, Jamia Hamdard, New Delhi, India.

A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti-malarial activities. Among the compounds tested, compound 11a was found to be potent against the HCT-15 cancer cell line with IC  = 4. Read More

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December 2018
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A clinical trial with protracted infusion 5-fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus.

Asia Pac J Clin Oncol 2018 Dec 9. Epub 2018 Dec 9.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Purpose: Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcomes of patient-initiated treatment interruption for severe acute toxicity.

Materials And Methods: This was a prospective, nonrandomized study for patients with T1-4N0-3M0 anal squamous carcinoma. Read More

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December 2018
2 Reads

Immediate remote ischemic postconditioning reduces cerebral damage in ischemic stroke mice by enhancing leptomeningeal collateral circulation.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Remote ischemic postconditioning (RIPC) is a promising neuroprotective strategy for ischemic stroke. Here, we employed a focal ischemic stroke mouse model to test the hypothesis that poststroke collateral circulation as a potent mechanism of action underlying the therapeutic effects of immediate RIPC. During reperfusion of cerebral ischemia, the mice were randomly assigned to receive RIPC, granulocyte colony-stimulating factor (G-CSF) as a positive control, or no treatment. Read More

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December 2018

Ototoxicity in locally advanced head and neck cancer patients treated with induction chemotherapy followed by intermediate or high-dose cisplatin-based chemoradiotherapy.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: This study evaluated ototoxicity in locally advanced head and neck cancer patients treated in the CONDOR study with docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with concomitant cisplatin 100 mg/m on days 1, 22, and 43 (cis100+RT) versus accelerated radiotherapy with concomitant cisplatin weekly 40 mg/m (cis40+ART).

Methods: Sixty-two patients were treated in this study. Audiometry was performed at baseline, during TPF, before start of chemoradiotherapy, and 1, 4, 8, and 12 months after treatment. Read More

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December 2018

The Effectiveness of Hepatic Arterial Infusion Chemotherapy with 5-Fluorouracil/Cisplatin and Systemic Chemotherapy with Ramucirumab in Alpha-Fetoprotein-Producing Gastric Cancer with Multiple Liver Metastases.

Case Rep Oncol Med 2018 11;2018:5402313. Epub 2018 Nov 11.

Department of Pathology, Kurume University Hospital, Kurume, Japan.

Alpha-fetoprotein- (AFP-) producing gastric cancer (AFPGC) is characterized by a high incidence of liver and lymph node metastases and poor prognosis. Although several case reports have described successful multidisciplinary treatment, there are currently no standard therapies for AFPGC. A 57-year-old man presented with upper abdominal pain. Read More

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November 2018
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Indole Alkaloid Derivative B, a Novel Bifunctional Agent That Mitigates 5-Fluorouracil-Induced Cardiotoxicity.

ACS Omega 2018 Nov 21;3(11):15850-15864. Epub 2018 Nov 21.

Department of Chemistry and Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, United States.

Clinically approved therapeutics that mitigate chemotherapy-induced cardiotoxicity, a serious adverse effect of chemotherapy, are lacking. The aim of this study was to determine the putative protective capacity of a novel indole alkaloid derivative B () against 5-fluorouracil (5-FU)-induced cardiotoxicity. To assess the free-radical scavenging activities of , the acetylcholine-induced relaxation assay in rat thoracic aorta was used. Read More

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November 2018

Prevalence of elevated microsatellite alterations at selected tetranucleotide repeats in pancreatic ductal adenocarcinoma.

PLoS One 2018 7;13(12):e0208557. Epub 2018 Dec 7.

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Pancreatic ductal adenocarcinoma (PDAC) prognosis remains poor even after complete resection owing to no valuable biomarkers for recurrence and chemosensitivity. Tumors not expressing MSH3 show elevated microsatellite alterations at selected tetranucleotide repeats (EMAST). EMAST reportedly occurs in several tumors. Read More

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December 2018

Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence.

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

University of Texas Southwestern Medical Center Department of Cell Biology, 5323 Harry Hines Blvd. Dallas, TX 75390.

Keloids are benign fibroproliferative skin tumors which can cause disfigurement and disability. While they frequently recur after excision or medical management and can affect 6-16% of African Americans, there is no gold standard therapy. Keloids are challenging to study because there are no animal or in vitro models of this disorder. Read More

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November 2018

5-Fluorouracil rechallenge after 5-fluorouracil-induced hyperammonemic encephalopathy.

Anticancer Drugs 2018 Dec 10. Epub 2018 Dec 10.

Medical Oncology Department, Gustave Roussy, Université Paris-Saclay.

For several decades, 5-Fluorouracil (5-FU) has been the backbone of many chemotherapy regimens for various tumor types. Its most common side effects are gastrointestinal disorders, mucositis, myelosuppression, hand-foot syndrome, and rarely cardiac toxicity. More rarely, 5-FU infusion can induce hyperammonemic encephalopathy. Read More

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December 2018

Oxaliplatin, 5-Fluorouracil and Nab-paclitaxel as perioperative regimen in patients with resectable gastric adenocarcinoma: A GERCOR phase II study (FOXAGAST).

Eur J Cancer 2018 Dec 7;107:46-52. Epub 2018 Dec 7.

Medical Oncology Department, Institut Mutualiste Montsouris, Paris, France. Electronic address:

Background: 5-Fluorouracil (5-FU) and platinum-based perioperative chemotherapy is standard of care for resectable gastric adenocarcinoma (RGA). Nanoparticle albumin-bound (Nab-) paclitaxel is active in advanced disease but has never been evaluated in the perioperative setting. The objective was to evaluate the efficacy of Nab-paclitaxel in combination with FOLFOX for RGA patients. Read More

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December 2018
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5 fluorouracil as an adjuvant therapy along with microneedling in vitiligo.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Consultant Dermatologist & Dermatosurgeon, Skinnocence: The Skin Clinic, Gurgaon, India.

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December 2018

Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.

Behav Brain Res 2018 Dec 7. Epub 2018 Dec 7.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address:

Fatigue is a common symptom in many diseases and disorders and can reduce quality of life, yet lacks an adequate pharmacological intervention. To identify and develop such interventions, and to better understand fatigue, additional preclinical research is necessary. However, despite numerous mouse behavioral assays reportedly detecting fatigue-like behavior, the assumption that fatigue-like behavior is detected in many assays has not been validated through a cross-assay study. Read More

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December 2018

Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents.

Eur J Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

5-Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent however, its use is associated with several debilitating adverse effects such as intestinal mucositis (IM) and myelosuppression. Oxidative stress and inflammation are major contributors in the development of mucositis. Diadzein is known for its potent anti-inflammatory and anti-oxidative activities from decades. Read More

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December 2018

[Predictive and prognostic value of MSI phenotype in adjuvant colon cancer: Who and how to treat?]

Bull Cancer 2018 Dec 4. Epub 2018 Dec 4.

European Georges Pompidou Hospital, AP-HP, Department of Gastroenterology and Digestive Oncology, Paris, France.

The MSI phenotype in colon cancer is a good prognostic factor, with an impact probably more pronounced for stage II than stage III tumor. This survival advantage may be related to the tumor-infiltrating lymphocytes observed in MSI tumors, thus explaining the existence of a probably more effective anti-tumor immune response. In addition, the MSI status would also be a biomarker able to predict the lack of efficacy of adjuvant 5-fluorouracil (5FU) chemotherapy. Read More

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December 2018

Design, Synthesis and Therapeutic Potential of some 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues.

Mini Rev Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan. Malaysia.

A library of 6, 6'-(1,4-phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine) derivatives has been synthesized by Claisen-Schmidt condensation and its chemical structure was confirmed by FT-IR, 1H/13C-NMR spectral and elemental analyses. The molecular docking study was carried to find the interaction between active bis-pyrimidine compounds with CDK-8 protein. The in vitro antimicrobial potential of the synthesized compounds was determined against Gram-positive and Gram-negative bacteria species as well fungal species by tube dilution technique. Read More

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December 2018

Molecular mechanism of inhibition of acid ceramidase by carmofur.

J Med Chem 2018 Dec 7. Epub 2018 Dec 7.

Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors. Despite the strong interest in obtaining structural information, only the structures of the apo-AC enzyme in its zymogen and activated conformations are available. In this work, the crystal structure of AC in complex with the covalent carmofur inhibitor is presented. Read More

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December 2018
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Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer.

ACS Nano 2018 Dec 11. Epub 2018 Dec 11.

Division of Nanomedicine, Department of Medicine , University of California , Los Angeles , California 90095 , United States.

Irinotecan is a key chemotherapeutic agent for the treatment of colorectal (CRC) and pancreatic (PDAC) cancer. Because of a high incidence of bone marrow and gastrointestinal (GI) toxicity, Onivyde (a liposome) was introduced to provide encapsulated irinotecan (Ir) delivery in PDAC patients. While there is an ongoing clinical trial (NCT02551991) to investigate the use of Onivyde as a first-line option to replace irinotecan in FOLFIRINOX, the liposomal formulation is currently prescribed as a second-line treatment option (in combination with 5-fluorouracil and leucovorin) for patients with metastatic PDAC who failed gemcitabine therapy. Read More

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December 2018

An Organoid-Based Preclinical Model of Human Gastric Cancer.

Cell Mol Gastroenterol Hepatol 2018 Sep 20;7(1):161-184. Epub 2018 Sep 20.

Department of Pathology and Lab Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Background & Aims: Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response in individual patients.

Methods: Organoids were derived from resected gastric cancer tumors (huTGOs) or normal stomach tissue collected from sleeve gastrectomies (huFGOs). Organoid cultures were treated with standard-of-care chemotherapeutic drugs corresponding to patient treatment: epirubicin, oxaliplatin, and 5-fluorouracil. Read More

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September 2018

Paclitaxel, 5-fluorouracil, and leucovorin combination chemotherapy as first-line treatment in patients with advanced gastric cancer.

Anticancer Drugs 2018 Dec 4. Epub 2018 Dec 4.

Medical Oncology, Fujian Medical University Union Hospital.

The aim of this retrospective analysis was to evaluate the efficacy and toxicity of combination chemotherapy with paclitaxel, 5-fluorouracil, and leucovorin (TFL) as first-line treatment in patients with advanced gastric cancer (AGC). One hundred and thirteen patients were enrolled in the study who were confirmed to have AGC by histopathology. These patients were treated with TFL: paclitaxel at a dose of 135 mg/m as a 3-h intravenous infusion on day 1, LV 400 mg/m as an intravenous infusion over 2 h on day 1, followed by 5-fluorouracil 2400 mg/m as an infusion over a 46-h period on 3 consecutive days. Read More

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December 2018

Evaluation of Cytotoxic Potentials of Some Isoindole-1,3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines.

Med Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum. Turkey.

Background: Norcantharimides are known as norcantharidine derivatives and contain an isoindole skeleton structure. Isoindole derivatives have positively effect on inflammatory pathologies including cancers.

Objective: Considering this information, firstly, isoindole derivatives containing different functional groups 4-13 have been synthesized from 2-alkyl/aryl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione. Read More

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December 2018

5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells.

J Toxicol Sci 2018 ;43(12):727-734

Division of Pharmacology, National Institute of Health Sciences, Japan.

5-fluorouracil (5-FU) has been widely used for the treatment of tumors. Regardless of its widespread use as an anti-cancer drug, 5-FU therapy can cause several side effects, including developmental toxicity and neurotoxicity. However, the potential action of 5-FU at the early fetal stage has not yet been completely elucidated. Read More

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January 2018

Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

Bioorg Chem 2018 Nov 22;84:260-268. Epub 2018 Nov 22.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

Trimellitimides 6-21 were prepared and investigated in vivo for anti-inflammatory and ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro cyclooxygenase (COX-1/2) and carbonic anhydrase inhibition protocols. Compounds 6-11 and 18 exhibited anti-inflammatory activities and had median effective doses (ED) of 34. Read More

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November 2018

Synthesis and biological profile of substituted benzimidazoles.

Chem Cent J 2018 Dec 1;12(1):125. Epub 2018 Dec 1.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, 51452, Kingdom of Saudi Arabia.

Background: A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities.

Results And Discussion: The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. Read More

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December 2018
2 Reads

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives.

Acta Pharm Sin B 2018 Oct 18;8(6):862-880. Epub 2018 May 18.

Department of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Gyeonggi-do 14662, Republic of Korea.

Mitochondrial targeting is a promising approach for solving current issues in clinical application of chemotherapy and diagnosis of several disorders. Here, we discuss direct conjugation of mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium (TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Read More

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October 2018
2 Reads

Radiation Therapy for Anal Squamous Cell Carcinoma: A Retrospective Multicenter Study.

Anticancer Res 2018 Dec;38(12):6931-6938

Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea

Aim: To analyze the treatment outcomes, patterns of failures and prognostic factors for patients with anal cancer treated with radiotherapy (RT).

Materials And Methods: Between January 2000 and December 2015, 83 patients with anal squamous cell carcinoma were treated with definitive RT. The median RT dose applied to the primary carcinoma site was 55 (range=45-64) Gy. Read More

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December 2018
1 Read

Chemotherapy in Patients with Hereditary Angioedema.

Anticancer Res 2018 Dec;38(12):6801-6807

Internal Medicine Department, Tor Vergata University Hospital, Medical Oncology Unit, Rome, Italy.

Background: Hereditary angioedema (HAE) is an autosomal dominant hereditary disorder characterized by episodic swelling of many body regions (especially throat and abdomen), potentially triggered by medication. No data are available for HAE in patients with cancer assigned to standard chemotherapy. The aim of our study was to identify circulating mediators potentially predictive of acute HAE attacks during chemotherapy. Read More

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December 2018
1 Read

Iatrogenic limbal stem cell deficiency following drainage surgery for glaucoma.

Can J Ophthalmol 2018 Dec 2;53(6):574-579. Epub 2018 Apr 2.

Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

Objective: To describe conjunctival epithelial overgrowth of the cornea after surgery for glaucoma.

Methods: This is a retrospective case series (setting: Moorfields Eye Hospital). Fourteen eyes of 13 patients with suspected limbal stem cell deficiency (LSCD) and corneal conjunctivalization after glaucoma drainage surgery. Read More

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December 2018

Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy.

J Pharmacol Toxicol Methods 2018 Nov 28;95:70-78. Epub 2018 Nov 28.

CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, Covilhã, Portugal. Electronic address:

Introduction: The evaluation of drug's cytotoxicity is a crucial step in the development of new pharmacological compounds. P NMR can be a tool for toxicological screening, as it enables the study of drugs' cytotoxicity and their effect on cell energy metabolism in a real-time, in a non- invasive and non-destructive way. This paper details a step-by-step protocol to implement a bioreactor system able to maintain cell viability during NMR acquisitions, at high cell densities and for several hours, enabling toxicological evaluation of pharmacological compounds in living cells. Read More

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November 2018
2 Reads

Phase II study of metabolic response to one-cycle chemotherapy in patients with locally advanced esophageal squamous cell carcinoma.

J Formos Med Assoc 2018 Nov 27. Epub 2018 Nov 27.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University Cancer Center, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, No 1, Jen Ai Road Section 1, Taipei, 10051, Taiwan. Electronic address:

Background: In the treatment of esophageal squamous cell carcinoma (ESCC), the optimal use of fluorodeoxyglucose positron emission tomography (PET) in measuring metabolic tumor response is undetermined. We launched a phase II trial to evaluate early metabolic response to one-cycle induction chemotherapy in patients with locally advanced ESCC.

Methods: ESCC patients in stage classification T3N0, N1M0, or M1a (American Joint Committee on Cancer, 6th edition) received one-cycle chemotherapy comprising paclitaxel, cisplatin, and 24-h infusional 5-fluorouracil and leucovorin on days 1 and 8, followed by neoadjuvant chemoradiotherapy, 40 Gy, with paclitaxel/cisplatin and then esophagectomy. Read More

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November 2018
1 Read

Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Oncology VU University Medical Center De Boelelaan 1118, 1081 HV Amsterdam. Netherlands.

Background: Inherent or acquired chemo resistance in cancer patients has been a perpetual limitation in cancer treatment. Expanding knowledge on essential cellular processes opens a new window for therapeutic targeting. Ribosome biogenesis is a process that shows potential due to its fundamental role in cell development and contribution to tumorigenesis as a result of its upregulation. Read More

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December 2018
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Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Chem Cent J 2018 Dec 4;12(1):130. Epub 2018 Dec 4.

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Background: In view of wide range of biological activities of oxazole, a new series of oxazole analogues was synthesized and its chemical structures were confirmed by spectral data (Proton/Carbon-NMR, IR, MS etc.). The synthesized oxazole derivatives were screened for their antimicrobial and antiproliferative activities. Read More

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December 2018
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Development of a low-cost electrochemical sensor based on babassu mesocarp (Orbignya phalerata) immobilized on a flexible gold electrode for applications in sensors for 5-fluorouracil chemotherapeutics.

Anal Bioanal Chem 2018 Dec 5. Epub 2018 Dec 5.

Laboratório Interdisciplinar de Materiais Avançados - LIMAV, CT, UFPI, Campus Ministro Petrônio Portela, Teresina, PI, 64049-550, Brazil.

There are increasing concerns regarding the risks arising from the contamination of manipulators of antineoplastic drugs promoted by occupational exposure or even in the dosage of drugs. The present work proposes the use of an electrochemical sensor based on a biopolymer extracted from the babassu coconut (Orbignya phalerata) for the determination of an antineoplastic 5-fluorouracil (5-FU) drug as an alternative for the monitoring of these drugs. In order to reduce the cost of this sensor, a flexible gold electrode (FEAu) is proposed. Read More

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December 2018
2 Reads

DNA replication licensing proteins: Saints and sinners in cancer.

Semin Cancer Biol 2018 Nov 28. Epub 2018 Nov 28.

Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau. Electronic address:

DNA replication is all-or-none process in the cell, meaning, once the DNA replication begins it proceeds to completion. Hence, to achieve maximum control of DNA replication, eukaryotic cells employ a multi-subunit initiator protein complex known as "pre-replication complex or DNA replication licensing complex (DNA replication LC). This complex involves multiple proteins which are origin-recognition complex family proteins, cell division cycle-6, chromatin licensing and DNA replication factor 1, and minichromosome maintenance family proteins. Read More

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November 2018
5 Reads

Actinic keratosis and squamous cell carcinoma of the elderly

Rev Prat 2017 12;67(10):1084-1088

Service de gériatrie - plaies et cicatrisation, hôpital Rothschild, Assistance publique-Hôpitaux de Paris, Paris, France.

Actinic keratosis and squamous cell carcinoma in the elderly. The increase in life expectancy and the change in the habits of the population with respect to UV exposure have led to an increase in the incidence of actinic keratosis (AK) and squamous cell carcinoma (SCC). There is no specific recommendation for the "frail" elderly, but they would not differ much from the recommendations of the younger subjects. Read More

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December 2017
3 Reads

Treatment patterns and outcomes among patients with recurrent/metastatic squamous cell carcinoma of the head and neck.

Future Oncol 2018 Dec 4. Epub 2018 Dec 4.

Merck & Co., Inc., MRL, Center for Observational & Real World Evidence (CORE), Oncology, 2000 Galloping Hill Rd, Kenilworth, NJ 07033, USA.

Aim: Cetuximab was approved in 2008 for treating recurrent/metastatic (R/M) head-and-neck squamous-cell carcinoma (HNSCC), and this study assessed the utilization of cetuximab for R/M-HNSCC in a real-world setting.

Materials & Methods: Adult patients with R/M-HNSCC, who initiated systemic therapy between 1 September 2011 and  31 December 2014 and followed through 31 December 2015, were identified from iKnowMed electronic-health-records database (McKesson Specialty Health) supplemented with manual chart-abstraction.

Results: For 325 R/M-HNSCC patients; median age 62 years; 82% males, 67% had oropharyngeal cancer, most common first-line (1L) regimen was platinum-based combinations (76%), of whom only 8% received platinum + cetuximab +/- 5 fluorouracil. Read More

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December 2018

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.

Cell Mol Gastroenterol Hepatol 2019 14;7(1):73-91. Epub 2018 Sep 14.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address:

Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas. Read More

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September 2018

Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy.

Chin J Cancer Res 2018 Oct;30(5):526-536

Department of Gastroenterology, Cancer Institute, University of São Paulo Medical School, São Paulo 01246-000, Brazil.

Objective: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU. Read More

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October 2018
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Intralesional 5-Fluorouracil in the Treatment of Lower Leg Squamous Cell Carcinoma

J Drugs Dermatol 2018 Nov;17(11):1241-1243

Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in the United States.1,2 There are different treatment modalities for non-melanoma skin cancer, that include surgical excision, radiation therapy, cryotherapy, electrodessication and curettage, photodynamic therapy, and topical chemotherapy. Intralesional injection with 5-fluorouracil is a treatment modality that is not used often, perhaps due to not much research available to its effectiveness or established treatment recommendations. Read More

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November 2018
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Comparative Effectiveness and Safety of Monoclonal Antibodies (Bevacizumab, Cetuximab, and Panitumumab) in Combination with Chemotherapy for Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis.

BioDrugs 2018 Dec;32(6):585-606

Postgraduate Program in Medicines and Pharmaceutical Services, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Background: The last decade has seen the increasing use of biological medicines in combination with chemotherapy containing 5-fluorouracil/oxaliplatin or irinotecan for the treatment of metastatic colorectal cancer (mCRC). These combinations have resulted in increased progression-free survival (PFS) in patients with mCRC; however, there are remaining concerns over the extent of their effect on overall survival (OS). Published studies to date suggest no major differences between the three currently available monoclonal antibodies (MoAbs); however, there are differences in costs. Read More

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December 2018
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Clinical Value of Pharmacogenomic Testing in a Patient Receiving FOLFIRINOX for Pancreatic Adenocarcinoma.

Front Pharmacol 2018 15;9:1309. Epub 2018 Nov 15.

Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, United States.

Pharmacogenomic testing may have clinical value in the treatment of patients with gastrointestinal malignancies such as colorectal and pancreatic cancer. These types of cancer are often treated with combination chemotherapy regimens. These regimens can lead to severe adverse effects in patients with diminished drug tolerability potentially due to certain genetic variants in the enzymes involved in the metabolism of the chemotherapies. Read More

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November 2018
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Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations.

Genome Med 2018 11 29;10(1):92. Epub 2018 Nov 29.

Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Postboks 4953 Nydalen, 0424, Oslo, Norway.

Background: Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its receptor interaction, thus obstructing the formation of new blood vessels.

Methods: A phase II randomized clinical trial of 123 patients with Her2-negative breast cancer was conducted, with patients treated with neoadjuvant chemotherapy (fluorouracil (5FU)/epirubicin/cyclophosphamide (FEC) and taxane), with or without bevacizumab. Read More

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November 2018
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