2,933 results match your criteria Florid Cutaneous Papillomatosis


Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

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December 2018

Collagenous Spherulosis in Well-Differentiated Papillary Mesothelioma in a Female With Multilocular Peritoneal Inclusion Cysts.

Int J Surg Pathol 2018 Dec 6:1066896918816815. Epub 2018 Dec 6.

1 Rashid Hospital, Dubai, UAE.

Multilocular peritoneal inclusion cysts are mesothelial tumor-like lesions with or without small foci of florid papillary mesothelial hyperplasia that might simulate serous epithelial papillary lesions or well-differentiated papillary mesothelioma (WDPM) of the peritoneum. The papillary cores in papillary mesothelial hyperplasia and in WDPM display a variety of different histomorphologic features. To our knowledge, collagenous spherulosis in WDPM was not previously described or illustrated in the literature. Read More

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December 2018

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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December 2018
1 Read

Florid Nonmotor Manifestations of a Pathologically proven Progressive Supranuclear Palsy.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):345-346

Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.

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December 2018
1 Read

Intramural florid cystic endosalpingiosis of the uterus after menopause.

Pol J Pathol 2018 ;69(3):321-324

Endosalpingiosis is a benign condition characterized by the presence of tubal epithelium outside the fallopian tube and the absence of endometrial stroma. Florid cystic endosalpingiosis is a very rare form of endosalpingiosis that presents as a tumor-like lesion. We report the case of a 67-year-old woman who presented with a cystic lesion of the uterus. Read More

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January 2018
3 Reads

Pleomorphic and Florid Lobular Carcinoma in Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center.

Am J Surg Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, University of California San Francisco, San Francisco, CA.

The natural history and optimal treatment of pleomorphic (PLCIS) and florid (FLCIS) lobular carcinoma in situ variants remains uncertain. We reviewed the clinicopathologic features and management of LCIS variants at our institution over a 20-year period. Of 85 cases (61 PLCIS, 24 FLCIS), 77% were associated with invasive carcinoma (84% lobular, 13% ductal/lobular, 3% ductal) and only 17% (9 PLCIS, 5 FLCIS) were pure. Read More

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November 2018
2 Reads

[Etiological diagnosis of pulmonary hypertension: A cause of difficult diagnosis].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service de pneumologie de Louis-Pradel, centre national de référence des maladies pulmonaires rares, centre de compétence de l'hypertension pulmonaire, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Université Claude-Bernard Lyon 1, 8, avenue Rockefeller, 69008, Lyon, France. Electronic address:

Introduction: Schistosomiasis associated pulmonary arterial hypertension belongs to group 1 of the pulmonary hypertension classification and should be considered in any patient with pulmonary hypertension returning from an endemic area.

Case Report: A 17-year-old patient was hospitalized for pulmonary hypertension detected during the initial assessment of viral hepatitis B-related cirrhosis with portal hypertension. The initial assessment established the diagnosis of pulmonary hypertension secondary to viral hepatitis B-cirrhosis. Read More

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November 2018
5 Reads

Florid Scurvy in an Autistic Child on a Ketogenic Diet.

Pediatr Emerg Care 2018 Nov 19. Epub 2018 Nov 19.

From the Department of Emergency Medicine (Pediatric Unit), College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

Ketogenic diets used for treating various neurological disorders can have potentially serious adverse effects. Among these is scurvy, a rarely reported, yet potentially fatal adverse effect of the ketogenic diet caused by vitamin C deficiency. We report a case of a 5-year-old patient with autism, who presented with scurvy secondary to the dietary restrictions of a ketogenic diet. Read More

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November 2018
11 Reads

A 31 year old man with periostitis deformans.

Arthritis Care Res (Hoboken) 2018 Nov 19. Epub 2018 Nov 19.

Division of Rheumatology, Loma Linda University.

A case of a 31-year-old male was noted to have marked joint swelling and tenderness accompanied by elevated alkaline phosphatase, and florid periostitis on radiographs. The patient was under treatment for fungal infection with voriconazole. Discontinuation of voriconazole resulted in resolution of his symptoms and radiographic findings. Read More

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November 2018

Severe bilateral knee osteonecrosis in a young man with human immunodeficiency virus.

Radiol Case Rep 2019 Feb 9;14(2):208-212. Epub 2018 Nov 9.

London North West Healthcare NHS Trust, Infectious Diseases Department Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, UK.

We present a young man with a background Human Immunodeficiency virus (HIV) who presented with bilateral knee pain and reduced mobility. Subsequent imaging of the knees demonstrated florid osteonecrosis (ON), which was managed conservatively. ON is seen more commonly in HIV patients than the general population, however the underlying mechanism for this association is remains unclear. Read More

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February 2019
1 Read

Quantitative MRI in post-operative paediatric cerebellar mutism syndrome.

Eur J Radiol 2018 Nov 10;108:43-51. Epub 2018 Sep 10.

Developmental Imaging and Biophysics Section, UCL GOS Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom. Electronic address:

Post-operative paediatric cerebellar mutism syndrome (pCMS) occurs in around 25% of children undergoing surgery for cerebellar and fourth ventricular tumours. Reversible mutism is the hallmark of a syndrome which comprises severe motor, cognitive and linguistic deficits. Recent evidence from advanced neuroimaging studies has led to the current theoretical understanding of the condition as a form of diaschisis contingent on damage to efferent cerebellar circuitry. Read More

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November 2018
3 Reads

Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2018 Sep 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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September 2018
2 Reads

Discovery of coarctation of the aorta following renal doppler sonography.

Med J Malaysia 2018 Oct;73(5):330-331

Hospital Sungai Buloh, Department of Radiology, Sungai Buloh, Selangor, Malaysia.

Coarctation of the aorta (CoA) is present in 0.4% of live births and in 7% of patients with congenital heart disease. While there may be florid presentations of congestive heart failure in the neonatal period, the diagnosis during adulthood is often delayed. Read More

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October 2018
4 Reads

ACTH-Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature.

Clin Colorectal Cancer 2018 Aug 11. Epub 2018 Aug 11.

Division of Medical Oncology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background: Approximately 30% of neuroendocrine tumors (NETs) present with secretory syndromes or develop one during the course of the disease. Cushing syndrome caused by a gastrointestinal tract NET is rare, with limited published information. We describe a patient with florid Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) from a NET of colonic origin. Read More

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August 2018
1 Read

Rapidly progressive encephalopathy caused by Coxsackie meningoencephalitis in an elderly male.

J Neurovirol 2018 Dec 5;24(6):780-785. Epub 2018 Oct 5.

Department of Neurology, Division of Neurocritical Care and Program in Trauma, University of Maryland Medical Center, Baltimore, MD, USA.

Enteroviruses and Coxsackie viruses are common causes of aseptic meningitis and encephalitis in children. These infections usually have a benign, self-limited course. However, they can have a florid presentation in immunocompromised patients, such as neonates, patients exposed to immunosuppressive drugs, such as transplant recipients and patients with agammaglobulinemia. Read More

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December 2018
5 Reads

Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis.

Case Rep Pathol 2018 6;2018:6702561. Epub 2018 Sep 6.

Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, UK.

Neurofibromatosis type 1 is an autosomal dominant condition which can manifest as multiple neurofibromas within subcutaneous tissue. Neurofibromas of the breast are rare and most often encountered on the nipple-areolar complexes. A 33-year-old woman presented with large, bilateral, fleshy, skin tags of the nipple-areolar complexes. Read More

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September 2018
5 Reads

Incidental Finding of Intraperitoneal Tuberculosis in a Patient Presenting with a Large Ovarian Mass.

Case Rep Infect Dis 2018 9;2018:9805702. Epub 2018 Sep 9.

Hervey Bay Hospital, Urraween Rd, Pialba, QLD 4655, Australia.

A 52-year-old postmenopausal female of Filipino heritage presented with a three-day history of increasing abdominal bloating, vomiting, and fever. A CT scan revealed a 22 cm ovarian mass and ascites. Her laboratory results were unremarkable except for CA-125 and CA-19. Read More

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September 2018
1 Read

White matter connectivity reductions in the pre-clinical continuum of psychosis: A connectome study.

Hum Brain Mapp 2018 Sep 25. Epub 2018 Sep 25.

Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

Widespread white matter connectivity disruptions have commonly been reported in schizophrenia. However, it is questionable whether structural connectivity decline is specifically associated with schizophrenia or whether it extends along a continuum of psychosis into the healthy population. Elucidating brain structure changes associated with psychotic-like experiences in healthy individuals is insofar important as it is a necessary first step towards our understanding of brain pathology preceding florid psychosis. Read More

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September 2018
1 Read

Delusional infestation in the treatment of ADHD with atomoxetine.

BMJ Case Rep 2018 Sep 23;2018. Epub 2018 Sep 23.

Psychiatry, Huntlyburn, NHS Borders, Melrose, UK.

The case describes an adult diagnosed with attention deficit hyperactivity disorder and treated with atomoxetine who quickly developed a florid case of delusional infestation. The patient described very distressing experiences that were significantly impacting her daily life. The symptoms improved with the withdrawal of atomoxetine and resolved completely with antipsychotic medications. Read More

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September 2018
1 Read

A Case of Pseudomonas Orbital Cellulitis Following Glaucoma Device Implantation.

J Glaucoma 2018 Sep 18. Epub 2018 Sep 18.

University of Toronto Department of Ophthalmology and Vision Sciences.

Purpose: Orbital cellulitis is a rare complication of aqueous tube shunt surgery. Nine cases have been described in the literature, though the microbiologic etiology is rarely reported. Management with intravenous antibiotics and/or explantation has been described. Read More

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September 2018

Myofibroblastic infiltration of the bowel: A case report and literature review.

Int J Surg Case Rep 2018 6;51:248-251. Epub 2018 Sep 6.

Department of Colorectal Surgery, Maidstone and Tunbridge Wells NHS Trust, UK. Electronic address:

Introduction: Inflammatory myofibroblastic tumours (IMTs), are uncommon tumours which can act with malignant potential. The management of these tumours can be extremely problematic but are often referred to surgical multi-disciplinary team meetings with the intention of surgical and oncological management (Chaudhary [1]).

Case Report: A 69-year-old gentleman was admitted with a 2-day history of abdominal pain and vomiting, and a 4-day history of absolute constipation. Read More

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September 2018
2 Reads

Abdominal Physical Signs and Medical Eponyms: Part I. Physical Examination of Palpation, 1876-1907.

Clin Med Res 2018 Aug 30. Epub 2018 Aug 30.

University of Central Florida College of Medicine, Department of Internal Medicine, 6850 Lake Nona Blvd, Orlando, FL 32827

Background: Abdominal palpation is a difficult skill to master in the physical examination. It is through the tactile sensation of touch that abdominal tenderness is detected and expressed through pain. Its findings can be used to detect peritonitis and other acute and subtle abnormalities of the abdomen. Read More

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August 2018
6 Reads

Florid dermatopathic lymphadenopathy-A morphological mimic of Langerhans cell histiocytosis.

Clin Case Rep 2018 Aug 22;6(8):1637-1638. Epub 2018 Jun 22.

Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA.

The histopathology of reactive florid dermatopathic lymphadenopathy shows overlap with Langerhans cell histiocytosis (LCH) involving the lymph node, which may lead to misdiagnosis. These entities can be distinguished by recognition of the sinus-based distribution of Langerhans cells in LCH, in contrast to the paracortical distribution of Langerhans cells, pigment-laden histiocytes, and small lymphocytes in dermatopathic lymphadenopathy. Read More

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August 2018
9 Reads

Florid reactive periostitis of the metacarpal bone: a case of resolution without resection.

J Hand Surg Eur Vol 2018 Dec 16;43(10):1118-1119. Epub 2018 Aug 16.

1 The Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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December 2018

Florid cemento-osseous dysplasia: a contraindication to orthodontic treatment in compromised areas.

Dental Press J Orthod 2018 May-Jun;23(3):26-34

Universidade Estadual de Feira de Santana, Curso de Odontologia (Feira de Santana/BA, Brazil).

Florid cemento-osseous dysplasia is a sclerosing disease that affects the mandible, especially the alveolar process, and that is, in most cases, bilateral; however, in some cases it affects up to three or even four quadrants. During the disease, normal bone is replaced with a thinly formed, irregularly distributed tissue peppered with radiolucent areas of soft tissue. Newly formed bone does not seem to invade periodontal space, but, in several images, it is confused with the roots, without, however, compromising pulp vitality or tooth position in the dental arch. Read More

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Subclinical Endocarditis Might be a Hidden Trigger of Early Prosthetic Valve Calcification: A Histological Study.

Heart Surg Forum 2018 07 2;21(4):E300-E304. Epub 2018 Jul 2.

Department of Cardiac Surgery, Dresden Heart Center, Dresden University of Technology, Dresden, Germany.

Objective: Despite various improvements in valve prosthetics, early valve deterioration still occurs, leading to prosthetic failure. Studying the early phase of this deterioration is quite difficult, as the prosthesis to be examined is almost always explanted only after extensive deterioration. The objective of this research is to study the pathology of early valve deterioration in an early stage in order to reveal the possible trigger of the process. Read More

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July 2018
1 Read

Florid hyperandrogenism due to a benign adrenocortical adenoma.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Endocrinologist, Centre of Endocrinology Diabetes & Metabolism, Limassol, Cyprus.

A 26-year-old woman with a history of polycystic ovarian syndrome presented with secondary amenorrhea, worsening hirsutism, acne, deepening of voice and unexplained 10-20 kg weight gain. Her Ferriman-Gallway hirsutism score was 12 with cystic facial acne and increased masculine phenotype. Urine Beta-Human Chorionic Gonadotropins (bHCG) was negative. Read More

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July 2018
3 Reads

Florid Proliferation of Hyalinized Vessels in a Spermatic Cord STAT6 Positive Solitary Fibrous Tumor and Its Potential Clinical Implications.

Case Rep Pathol 2018 28;2018:7462032. Epub 2018 Jun 28.

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

A solitary fibrous tumor (SFT) arising in the paratesticular region is a rare event. Typically most SFTs present as a lung mass and have a characteristic microscopic appearance. Although uncommon, SFTs may present at just about any anatomical site. Read More

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June 2018
2 Reads

[Operative therapy of chronic palmar luxation of the distal ulna in florid CRPS - two cases].

Handchir Mikrochir Plast Chir 2018 06 25;50(3):202-206. Epub 2018 Jul 25.

Vulpiusklinik, Abteilung für Handchirurgie.

We present two cases of chronic palmar luxation of the distal ulna which entails the development of complex regional pain syndrome (CRPS). Both cases have been finally treated with a hemiresection-interposition-arthroplasty of the distal radioulnar joint with perioperatively applied regional nerve block and i. v. Read More

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Florid cystic endosalpingiosis with uterine preservation and successful assisted reproductive therapy.

Gynecol Oncol Rep 2018 Aug 9;25:8-10. Epub 2018 May 9.

Mayo Clinic Department of Obstetrics and Gynecology, United States.

•While endosalpingiosis is often asymptomatic & incidental, florid cystic endosalpingiosis can have a variable presentation•Cystic endosalpingiosis can be difficult to differentiate from other non-neoplastic peritoneal inclusion cysts•Although associated with serous pelvic neoplasms, there is no evidence for oophorectomy at the completion of fertility•There is no strong evidence that hysterectomy along with cyst resection leads to improved outcomes if pathology is benign•This is the first reported case of successful assisted-reproductive therapy after resected florid cystic endosalpingiosis. Read More

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August 2018
9 Reads

A case series of Kimura's disease: a diagnostic challenge.

Ther Adv Hematol 2018 Jul 25;9(7):207-211. Epub 2018 Jun 25.

Department of Hematology-Oncology, Maimonides Cancer Center, 6300 8th avenue, Brooklyn, NY 11220, USA.

Kimura's disease (KD) is a rare, benign disorder characterized by subcutaneous masses with regional lymph-node enlargement. It is considered to be due to chronic inflammation of unclear etiology. Most cases have been reported in young, 20-30-year-old men of Asian descent. Read More

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July 2018
13 Reads

Vastus Lateralis Muscle Free Flap for Skull Base Osteoradionecrosis in Nasopharyngeal Carcinoma.

J Neurol Surg B Skull Base 2018 Aug 27;79(4):349-352. Epub 2017 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

 To describe the first experience with a free vastus lateralis muscle-only flap to be used to cover and protect the exposed skull base and carotid artery from radiotherapy-induced skull base osteoradionecrosis (ORN).  Retrospective review of a case series.  Tertiary academic medical center. Read More

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August 2018
1 Read

Insufficiency fractures: A rare cause of foot and ankle pain in three patients with rheumatoid arthritis.

Radiol Case Rep 2018 Aug 29;13(4):855-861. Epub 2018 Jun 29.

Radiology Department, Ealing Hospital, Uxbridge Rd, Southall, London UB1 3HW, UK.

Insufficiency fractures are recognized but rare complications in patients with longstanding rheumatoid arthritis. Such fractures are typically solitary and are rarely seen to affect the foot and ankle. We describe 3 women with longstanding rheumatoid arthritis, treated with one, or a combination of, corticosteroids, DMARDs and anti-TNF, presenting with foot and ankle pain with no prior history of trauma. Read More

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Heartfelt sepsis: microvascular injury due to genomic storm.

Authors:
Jacek Hawiger

Kardiol Pol 2018 5;76(8):1203-1216. Epub 2018 Jul 5.

Vanderbilt University Medical Center.

Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulner-able patients, with these groups suffering from the highest sepsis mortality. Read More

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July 2018
2 Reads

Recurrent symptomatic cemento-osseous dysplasia: A case report.

Imaging Sci Dent 2018 Jun 19;48(2):131-137. Epub 2018 Jun 19.

Department of Oral and Maxillofacial Radiology, School of Dentistry, Chonbuk National University, Jeonju, Korea.

Cemento-osseous dysplasia (COD) is a benign fibro-osseous lesion of bone, in which normal bone is replaced by fibrous tissue, followed by calcification with osseous and cementum-like tissue. COD is classified into 3 categories according to its location: periapical, focal, and florid COD (FCOD). On radiography, FCOD appears radiolucent in its early stages. Read More

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June 2018
2 Reads

[Reconstruction using the tensor fasciae latae muscle flap].

Oper Orthop Traumatol 2018 Aug 27;30(4):228-235. Epub 2018 Jun 27.

Klinik für Plastische, Ästhetische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hamburg, Deutschland.

Objective: The tensor fasciae latae (TFL) muscle flap can be used for reconstruction of decubital ulcers in the trochanteric or ischial region.

Indications: Deep decubital ulcers in the gluteal or ischial area after debridement and exhaustion of conservative measures.

Contraindications: Moribund or palliative patients who do not benefit from defect coverage and are likely to suffer a life-threatening complication. Read More

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August 2018
1 Read

Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata.

Front Immunol 2018 6;9:1279. Epub 2018 Jun 6.

Functional Proteome Analysis, German Cancer Research Center, Heidelberg, Germany.

The treatment of autoimmune diseases still poses a major challenge, frequently relying on non-specific immunosuppressive drugs. Current efforts aim at reestablishing self tolerance using immune cells with suppressive activity like the regulatory T cells (Treg) or the myeloid-derived suppressor cells (MDSC). We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). Read More

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June 2018
3 Reads

[Components of the joint-sparing, combined bony and soft tissue correction of the cavovarus foot].

Authors:
A Wallroth T Dreher

Oper Orthop Traumatol 2018 Jun 21. Epub 2018 Jun 21.

Sektion Kinderorthopädie, Neuroorthopädie und Fußchirurgie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

Objective: Combined bony and soft tissue correction of a mild foot and flexible rearfoot deformity in cavovarus foot.

Indications: Drop foot during swing phase and muscular imbalance in the stance phase in cavovarus foot, flexible cavovarus foot, accompanying symptoms such as recurrent calluses and ulcerations, compliance.

Contraindications: Pes cavovarus of spastic genesis, mild deformities, fixed bony deformity, lack of compliance, florid inflammation in the foot area, severe peripheral artery disease (PAD), diabetes mellitus. Read More

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June 2018
7 Reads

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

J Autoimmun 2018 Aug 8;92:104-113. Epub 2018 Jun 8.

Institute of Inflammation and Ageing, ARUK Rheumatoid Arthritis Centre of Excellence, MRC ARUK Centre for Musculoskeletal Ageing, University of Birmingham, Birmingham, UK; Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Objective: In rheumatoid arthritis, the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is highly expressed at sites of inflammation, where it converts inactive glucocorticoids (GC) to their active counterparts. In conditions of GC excess it has been shown to be a critical regulator of muscle wasting and bone loss. Here we examine the contribution of 11β-HSD1 to the pathology of persistent chronic inflammatory disease. Read More

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Severe eosinophilic colitis caused by neuropathic agents in a patient with chronic fatigue syndrome and functional abdominal pain: case report and review of the literature.

Z Gastroenterol 2018 06 11;56(6):573-577. Epub 2018 Jun 11.

GI Physiology Unit, Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.

Eosinophilic colitis is a rare clinical condition that belongs to the group of eosinophilic gastrointestinal disorders. Its occurrence can be primary or secondary to infection, medications, or autoimmune/hematological conditions. We present a case of a young female adult with severe chronic fatigue syndrome, widespread chronic pain, including functional abdominal pain, who developed severe eosinophilic colitis following successive treatments with gabapentin and pregabalin. Read More

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June 2018
5 Reads

[Florid cemento-osseous dysplasia: a case report].

Authors:
P Y Zhang C Xiao

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Jun;53(6):431-432

Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou Jiangsu 215006, China.

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June 2018
1 Read

Crystal-storing Histiocytosis in the Stomach: A Clue to Subtle Hematolymphoid Malignancies.

Am J Surg Pathol 2018 Oct;42(10):1317-1324

Department of Pathology.

Crystal-storing histiocytosis (CSH) is an under-recognized entity with a striking association with lymphoproliferative disorders. To study the typical morphologic features of gastric CSH, all lymphomas diagnosed on in-house gastric specimens at The Ohio State University between January 1, 2008 and January 1, 2017 were retrieved. This search yielded 66 specimens from 51 unique patients. Read More

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October 2018
7 Reads

Malignant peritoneal mesothelioma in patients with endometriosis.

J Clin Pathol 2018 Nov 23;71(11):971-974. Epub 2018 May 23.

Department of Pathology, Duke University Health System, Durham, North Carolina, USA.

Aims: Florid mesothelial hyperplasia is known to result from endometriosis. Well-differentiated papillary mesothelioma and multiloculated peritoneal inclusion cysts have also been described in women with endometriosis. To our knowledge, peritoneal diffuse malignant mesothelioma (MM) arising in the setting of endometriosis has not been reported. Read More

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November 2018
3 Reads

Lethal phlegmonous colitis.

Med Sci Law 2018 Jul 21;58(3):186-188. Epub 2018 May 21.

2 The University of Adelaide, Australia.

A 52-year-old man died soon after admission to hospital with a severe metabolic acidosis and likely sepsis. He had a past history of alcohol abuse with withdrawal seizures. An abdominal computed tomography scan showed thickened bowel loops but no obvious ischaemic changes, and a blood culture yielded a pure growth of Escherichia coli. Read More

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[Flap coverage using the posterior gluteal thigh flap].

Oper Orthop Traumatol 2018 Aug 17;30(4):245-252. Epub 2018 May 17.

Klinik für Plastische, Ästhetische, Hand- und Wiederherstellungschirurgie Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Objective: Defect coverage of the sacral, trochanteric or ischial region with durable tissue (gluteal thigh flap).

Indications: Decubital ulcers of the sacral, trochanteric or ischial region after exhaustion of conservative measures.

Contraindications: Moribund or palliative patients who do not benefit from defect coverage and are likely to suffer a life-threatening complication. Read More

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The cortical damage, early relapses, and onset of the progressive phase in multiple sclerosis.

Neurology 2018 Jun 16;90(24):e2107-e2118. Epub 2018 May 16.

From the Division of Neuroscience (A.S., R.S.N., M.M., P.M.), Imperial College, London, UK; Biology Department (C.R.), University of Padua; Department of Neurological, Biomedicine and Movement Sciences (R.M., S.M., M.C.), University of Verona; and Neuroradiology Unit (A.M.), Euganea Medica, Padua, Italy.

Objective: To investigate the relationship among cortical radiologic changes, the number of early relapses (ERs), and the long-term course of multiple sclerosis (MS).

Methods: In this cohort study, we assessed the number of cortical lesions (CLs) and white matter (WM) lesions and the cortical thickness (Cth) at clinical onset and after 7.9 mean years among 219 patients with relapsing remitting (RR) MS with 1 (Low-ER), 2 (Mid-ER), and ≥3 (High-ER) ERs during the first 2 years. Read More

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June 2018
1 Read

Evaluating agreement, histological features, and relevance of separating pleomorphic and florid lobular carcinoma in situ subtypes.

Hum Pathol 2018 Aug 9;78:163-170. Epub 2018 May 9.

Women and Infants Hospital of Rhode Island, Department of Pathology, Providence, RI, United States.

Morphological variants of lobular carcinoma in situ (LCIS) include classical (CLCIS), pleomorphic (PLCIS) and florid type (FLCIS). Treatment guidelines suggest managing PLCIS and FLCIS like ductal carcinoma in situ (DCIS); therefore accurate identification of LCIS subtypes is critical. However, the significance of separating PLCIS from FLCIS is not clear. Read More

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August 2018
1 Read

Immunoglobulin G4-related disease of the paranasal sinuses.

BMJ Case Rep 2018 May 7;2018. Epub 2018 May 7.

ENT Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK.

Immunoglobulin G4-related disease (IgG4-RD) is becoming increasingly documented. It was first described in relation to autoimmune pancreatitis. Features of the disease include tissue infiltration by IgG4 plasma cells with associated fibrosis and the growth of pseudotumours. Read More

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May 2018
2 Reads