1,827 results match your criteria Floppy Eyelid Syndrome


Modified Corneal Incisions for Cataract Surgery in Patients Treated with Tamsulosin: A Prospective Study.

Curr Eye Res 2018 Dec 7. Epub 2018 Dec 7.

a Department of Ophthalmology , Meir Medical Center , Kfar Sava , Israel.

Purpose: To evaluate modified anterior elongated corneal incisions as a simple technique to reduce the incidence and severity of intraoperative floppy iris syndrome (IFIS), in patients taking tamsulosin (a selective α-adrenergic receptor antagonist).

Methods: This prospective case series was conducted at Meir Medical Center, a tertiary care facility in Israel. Included were 45 eyes of 39 male patients taking tamsulosin, and thus prone to IFIS. Read More

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December 2018

Predicting laryngeal exposure in microlaryngoscopy: External validation of the laryngoscore.

Laryngoscope 2018 Dec 3. Epub 2018 Dec 3.

ENT Clinic, Head and Neck Department, Trieste, Italy.

Objectives: Optimal laryngeal exposure during transoral laryngeal surgery is fundamental. We aimed to evaluate the reliability of a recently proposed score (Laryngoscore) in predicting difficult laryngeal exposure (DLE) in an independent cohort of patients undergoing elective microlaryngoscopy. We also verified the relation between DLE, surgeon's expertise, and difficult intubation, and investigated possible areas for score improvement. Read More

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December 2018
2 Reads

The role of sex in intraoperative floppy-iris syndrome.

J Cataract Refract Surg 2018 Nov 30. Epub 2018 Nov 30.

From the 2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

Purpose: To compare the incidence of intraoperative floppy-iris syndrome (IFIS) between male and female patients undergoing phacoemulsification cataract surgery, evaluate risk factors for its appearance in each sex, and assess any differences in the final visual outcomes.

Setting: 2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Greece.

Design: Comparative retrospective case-control study. Read More

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November 2018
4 Reads

RIGID GRAPH COMPRESSION: MOTIF-BASED RIGIDITY ANALYSIS FOR DISORDERED FIBER NETWORKS.

Multiscale Model Simul 2018 21;16(3):1283-1304. Epub 2018 Aug 21.

Carolina Center for Interdisciplinary Applied Mathematics, Department of Mathematics, University of North Carolina, Chapel Hill, NC 27599.

Using particle-scale models to accurately describe property enhancements and phase transitions in macroscopic behavior is a major engineering challenge in composite materials science. To address some of these challenges, we use the graph theoretic property of rigidity to model mechanical reinforcement in composites with stiff rod-like particles. We develop an efficient algorithmic approach called (RGC) to describe the transition from floppy to rigid in disordered fiber networks ("rod-hinge systems"), which form the reinforcing phase in many composite systems. Read More

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Diagnosis and management of floppy pouch complex.

Gastroenterol Rep (Oxf) 2018 Nov 3;6(4):246-256. Epub 2018 Jul 3.

Gastroenterology and Hepatology, Center for Inflammatory Bowel Disease, Cleveland Clinic, Cleveland, OH, USA.

Restorative proctocolectomy with ileal pouch-anal anastomosis has become the surgical treatment of choice for patients with refractory ulcerative colitis, colitis-associated dysplasia or familial adenomatous polyposis. There are various pouch disorders and associated complications. Floppy pouch complex is defined as the presence of pouch prolapse, afferent limb syndrome, enterocele, redundant loop and folding pouch on pouchoscopy, gastrografin pouchogram or defecography. Read More

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November 2018
8 Reads

Autonomous Actuation of Zero Modes in Mechanical Networks Far from Equilibrium.

Phys Rev Lett 2018 Oct;121(17):178001

Department of Mathematics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307, USA.

A zero mode, or floppy mode, is a nontrivial coupling of mechanical components yielding a degree of freedom with no resistance to deformation. Engineered zero modes have the potential to act as microscopic motors or memory devices, but this requires an internal actuation mechanism that can overcome unwanted fluctuations in other modes and the dissipation inherent in real systems. In this Letter, we show theoretically and experimentally that complex zero modes in mechanical networks can be selectively mobilized by nonequilibrium activity. Read More

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October 2018
2 Reads

Spectroscopy and Stability of AlOP: A Possible Progenitor of Interstellar Metal.

J Phys Chem A 2018 Nov 8. Epub 2018 Nov 8.

Standard and explicitly correlated coupled cluster theory computations in conjunction with large basis sets are performed to characterize the [Al,P,O] isomers. Three isomers, namely linear-AlOP, bent-AlOP and linear-OAlP, are found as stable species. Their optimized equilibrium geometries, harmonic vibrational frequencies, rotational constants and relative energies are deduced. Read More

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November 2018
3 Reads

Outcomes in resident-performed cataract surgeries with iris challenges: Results from the Perioperative Care for Intraocular Lens study.

J Cataract Refract Surg 2018 Dec 1;44(12):1469-1477. Epub 2018 Nov 1.

From the Department of Ophthalmology (Moustafa, Borkar, McKay, Lorch, Kloek), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, Retina Service (Borkar), Wills Eye Hospital, Philadelphia, Pennsylvania, Harvard Medical School (Eton), Boston, Massachusetts, and University of Southern California Roski Eye Institute (Koulisis), Keck School of Medicine, Los Angeles, California, USA.

Purpose: To assess the outcomes of resident-performed cataract surgeries with iris challenges and to compare these outcomes with similar surgeries performed by attending surgeons.

Setting: Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

Design: Retrospective chart review. Read More

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December 2018
3 Reads

The use of S-curved coaxial dilator for urethral dilatation: Experience of a tertiary department.

Urol Ann 2018 Oct-Dec;10(4):375-379

Department of Urology, University of Patras, Patras, Greece.

Objective: Urethral strictures can be treated by urethral dilation, optical internal urethrotomy, or open surgical reconstruction (urethroplasty). Urethral dilation is done with filiforms and followers, balloons, or coaxial dilators inserted over a guidewire. The S-curved coaxial dilator (SCCD) was designed to facilitate the passage of the dilator through the stricture and the urethra because it imitates the curved anatomy of the male urethra. Read More

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November 2018
3 Reads

Double Resonance Rotational Spectroscopy of Weakly Bound Ionic Complexes: The Case of Floppy CH_{3}^{+}-He.

Phys Rev Lett 2018 Oct;121(14):143001

I. Physikalisches Institut, Universität zu Köln, Zülpicher Straße 77, 50937 Köln, Germany.

A novel rotational spectroscopy method applicable to ions stored in cold traps is presented. In a double resonance scheme, rotational excitation is followed by vibrational excitation into a dissociative resonance. Its general applicability is demonstrated for the CH_{3}^{+}-He complex, which undergoes predissociation through its C-H stretching modes ν_{1} and ν_{3}. Read More

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October 2018

Did You Examine the Parents?

J Pediatr 2018 Oct 12. Epub 2018 Oct 12.

Pediatric Neurology Unit Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh, India.

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October 2018
3 Reads
3.790 Impact Factor

[Identification of a novel duplication of Xq13.1 in a case with floppy infant syndrome with SNP-array].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Oct;35(5):715-718

Medical Department, Xizang Minzu University, Xianyang, Shaanxi 712082, China.

Objective: To explore the candidate disease causing gene for a case with floppy infant syndrome (FIS).

Methods: Single nucleotide polymorphism array (SNP array) was used for analyzing the whole genome copy number mutations in the proband. Multiple PCR combined with denaturing high performance liquid chromatography (DHPLC) was employed to verify the suspected mutations in the proband and his family members. Read More

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October 2018
2 Reads

Large amplitude motion within acetylene-rare gas complexes hosted in helium droplets.

Phys Chem Chem Phys 2018 Oct 5. Epub 2018 Oct 5.

LIDYL, CEA, CNRS, Université Paris-Saclay, CEA Saclay, F-91191 Gif-sur-Yvette, France.

Near-infrared spectroscopy of the C2H2-Ar, Kr complexes was performed in the spectral region overlapping the ν3/ν2 + ν4 + ν5 Fermi-type resonance of C2H2. The experiment was conducted along the HElium NanoDroplet Isolation (HENDI) technique in order to study the coupling dynamics between a floppy molecular system (C2H2-Ar and C2H2-Kr) and a mesoscopic quantum liquid (the droplet). Calculations were performed using a spectral element based close-coupling program and state-of-the-art 2-dimensional potential energy surfaces to determine the bound states of the C2H2-Ar and C2H2-Kr complexes and simulate the observed spectra. Read More

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October 2018

Gastric tube volvulus following an Ivor-Lewis esophagectomy.

Ann R Coll Surg Engl 2018 Oct 5:e1-e4. Epub 2018 Oct 5.

First Department of Surgery, National and Kapodistrian University of Athens, Laikon University Hospital , Athens , Greece.

Gastric tube conduit is the method of choice for restoring continuity of the digestive track after a partial or total esophagectomy. Redundant gastric conduit (i.e. Read More

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October 2018
1 Read

Edge Modes and Asymmetric Wave Transport in Topological Lattices: Experimental Characterization at Finite Frequencies.

Phys Rev Lett 2018 Aug;121(9):094301

Department of Civil, Environmental, and Geo- Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Although topological mechanical metamaterials have been extensively studied from a theoretical perspective, their experimental characterization has been lagging. To address this shortcoming, we present a systematic, laser-assisted experimental characterization of topological kagome lattices, aimed at elucidating their in-plane phononic and topological characteristics. We specifically explore the continuum elasticity limit, which is established when the ideal hinges that appear in the theoretical models are replaced by ligaments capable of supporting bending deformation, as observed for instance in realistic physical lattices. Read More

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August 2018
1 Read
7.510 Impact Factor

Single nucleotide polymorphism array analysis uncovers a large, novel duplication in Xq13.1 in a floppy infant syndrome patient.

Int J Dev Neurosci 2018 Sep 12. Epub 2018 Sep 12.

Department of Operating room, Dezhou municipal hospital, Dezhou, China.

Objective: To identify candidate genes for the clinical diagnosis of floppy infant syndrome (FIS) using single nucleotide polymorphism (SNP) array in a specific FIS family.

Methods: SNP array analysis of the whole chromosome copy number was performed in the proband (III). Multiple polymerase chain reaction (PCR) combined with denaturing high-performance liquid chromatography (DHPLC) was used to validate the array data. Read More

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September 2018

Aortic Dysfunction in Mitral Regurgitation Due to Floppy Mitral Valve/Mitral Valve Prolapse.

Aorta (Stamford) 2018 Sep 12. Epub 2018 Sep 12.

Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio.

Background:  Floppy mitral valve/mitral valve prolapse (FMV/MVP), a heritable disorder of connective tissue, often leads to mitral regurgitation (MR) and is the most common cause for mitral valve surgery in developed countries. Connective tissue disorders may affect aortic function, and a stiff aorta may increase the severity of MR. Aortic function, however, has not been studied in FMV/MVP with MR. Read More

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September 2018
1 Read

Helium Tagging of Protonated Methane in Messenger Spectroscopy: Does It Interfere with the Fluxionality of CH ?

Angew Chem Int Ed Engl 2018 Nov 12;57(45):14792-14795. Epub 2018 Oct 12.

Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany.

Messenger infrared predissociation spectroscopy is an powerful technique to investigate elusive molecules. Despite accumulating evidence that He-tagging has a minor effect on structure due to its weak interactions, its impact on intramolecular large-amplitude motion is much less clear. Using one of the most floppy molecules known, protonated methane, we investigate to what extent helium tags perturb its salient fluxionality, underlying full hydrogen scrambling. Read More

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November 2018

Intraoperative complication rates in cataract surgery performed by ophthalmology resident trainees compared to staff surgeons in a Canadian academic center.

J Cataract Refract Surg 2018 Nov 7;44(11):1344-1349. Epub 2018 Sep 7.

From the Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: To compare the intraoperative complication rates in cataract surgery performed by resident trainees and staff ophthalmologists.

Setting: Kensington Eye Institute, University of Toronto, Toronto, Canada.

Design: Prospective case series. Read More

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November 2018

A sui generis electrode-driven spatial confinement effect responsible for strong twisting enhancement of floppy molecules in closely packed self-assembled monolayers.

Authors:
Ioan Bâldea

Phys Chem Chem Phys 2018 Sep;20(36):23492-23499

Theoretische Chemie, Universität Heidelberg, Im Neuenheimer Feld 229, D-69120 Heidelberg, Germany.

At present, it is widely accepted that properties (e.g., molecular conformation) of molecules adsorbed to form self-assembled monolayers (SAMs) on electrodes can be very different from isolated species because of a substantial charge transfer or specific chemical bonding at the interface. Read More

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September 2018

Photophysics of "Floppy" Dyads as Potential Biomembrane Probes.

J Fluoresc 2018 Sep 25;28(5):1225-1237. Epub 2018 Aug 25.

University of Potsdam, Institute of Chemistry (Physical Chemistry), Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany.

In the study a dyad (C6 probe), constructed of two dyes with highly different hydrophobicities, was investigated by steady-state and time-resolved spectroscopic techniques in chloroform, methanol, and in phospholipid vesicles, respectively. The dyad was built on two dyes: the lipophilic benzo[a]pyrene (BaP) and the hydrophilic sulforhodamine B (SRB). The dyes were linked via a short, but flexible alkyl chain (six C-atoms). Read More

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September 2018
2 Reads

Effect of phenylephrine 1.0%-ketorolac 0.3% injection on tamsulosin-associated intraoperative floppy-iris syndrome.

J Cataract Refract Surg 2018 Sep 2;44(9):1103-1108. Epub 2018 Aug 2.

From Silverstein Eye Centers (Silverstein) and the Department of Surgery (Silverstein), Department of Clinical Anatomy (V.K. Rana), Department of Anatomy (Stephens), the Department of Pharmacology (Segars), and Department of Clinical Anatomy (Pankratz), Kansas City University of Medicine and Biosciences, Kansas City, Missouri, and Kalamazoo College (S. Rana), Kalamazoo, and the Kresge Eye Institute (Juzych, Nariman), School of Medicine, Wayne State University, Detroit, Michigan, USA.

Purpose: To determine the effect of phenylephrine 1.0%-ketorolac 0.3% injection (Omidria) on different components of intraoperative floppy-iris syndrome (IFIS). Read More

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September 2018
1 Read

A family with floppy neonates with severe respiratory insufficiency: A lethal phenotype of RFT1-CDG due to a novel mutation.

Eur J Med Genet 2018 Jul 31. Epub 2018 Jul 31.

Department of Neonatology, Christian Medical College, Vellore, India. Electronic address:

Congenital disorders of glycosylation (CDG) are a rapidly expanding group of inborn errors of metabolism with around 100 types described so far. Because of the limited number of reported cases in each type except PMM2-CDG, the complete clinical picture of other types is not known. RFT1-CDG is a rare type, with ten cases reported in the literature. Read More

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July 2018
8 Reads

Pushing the Limits of Computational Structure-Based Drug Design with a Cryo-EM Structure: The Ca Channel α2δ-1 Subunit as a Test Case.

J Chem Inf Model 2018 Aug 13;58(8):1707-1715. Epub 2018 Aug 13.

Nostrum Biodiscovery , Jordi Girona 29, Nexus II D128 , 08034 Barcelona , Spain.

Cryo-electron microscopy (cryo-EM) is emerging as a real alternative for structural elucidation. In spite of this, very few cryo-EM structures have been described so far as successful platforms for in silico drug design. Gabapentin and pregabalin are some of the most successful drugs in the treatment of epilepsy and neuropathic pain. Read More

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Collateral closure in congenital heart defects with Amplatzer vascular plugs: single-center experience and a simplified delivery technique for exceptional cases.

Heart Vessels 2018 Jul 24. Epub 2018 Jul 24.

Department of Congenital Heart Disease and Pediatric Cardiology, Faculty of Medicine, Medical Center, University Heart Center Freiburg, Bad Krozingen, University of Freiburg, Mathildenstraße 1, 79106, Freiburg, Germany.

The study describes our experience with Amplatzer Vascular Plugs (AVP2 and 4) and highlights a more refindes telescopic technique for AVP2 delivery. AVPs are well-established occlusion devices for vascular anomalies in congenital heart disease (CHD). The AVP2 is sometimes preferred to the AVP4 due to its shorter length, flat-profiled retention disks, and the availability of larger diameters, but its profile requires a larger inner lumen for safe delivery. Read More

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July 2018
4 Reads

Penile Prosthesis Complications: Planning, Prevention, and Decision Making.

Sex Med Rev 2018 Jul 19. Epub 2018 Jul 19.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: Inflatable penile prosthesis (IPP) is an established treatment option for men with erectile dysfunction (ED) refractory to medical therapy. Standardization of surgical technique and improvements in device construction have reduced all-cause complication rates to less than 5% in recent reports. Nonetheless, complications do exist, and can strongly impact morbidity and the quality of life of patients. Read More

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July 2018
3 Reads

Revisiting the famous farm foxes: A psychological perspective.

Authors:
Jonathan D Lane

Learn Behav 2018 Dec;46(4):586-590

Vanderbilt University, Nashville, TN, USA.

Five decades ago, Dmitry Belyaev, Lyudmila Trut, and colleagues began a now-famous experiment, selectively breeding foxes based on one criterion: perceived tame behavior. Over generations, the fox population changed in behavior (as predicted) but, intriguingly, also changed markedly in appearance-for example, many had wider mouths, curlier tails, different fur coloring, and floppy ears. These researchers concluded that the morphological changes that appeared in their foxes were a by-product of the researchers' selecting for genetic variants that are implicated both in behavior and in appearance. Read More

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December 2018

External Nasal Valve Repair in Children: Alar Batten Graft Reinforced by External Temporary Suspensory Suture.

Ann Otol Rhinol Laryngol 2018 Sep 28;127(9):598-603. Epub 2018 Jun 28.

1 Zagazig University, Zagazig, Sharkia, Egypt.

Background: The nasal valve area is the narrowest point in the nasal airway. External nasal valve (ENV) collapse during inspiration occurs if external valve area is too narrow or its lateral component is too floppy.

Patients And Method: Twelve patients (7 males, 5 females) aged 8 to 12 years complaining of nasal obstruction due to ENV dysfunction underwent surgical intervention using alar batten graft assisted by temporary external suspensory suture. Read More

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September 2018

Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication.

BMC Biol 2018 Jun 28;16(1):64. Epub 2018 Jun 28.

Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.

Background: Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs display a vast array of phenotypes that differ from their ancestors, yet mirror other domesticated animal species, a phenomenon known as the domestication syndrome. Here, we use signatures persisting in dog genomes to identify genes and pathways possibly altered by the selective pressures of domestication.

Results: Whole-genome SNP analyses of 43 globally distributed village dogs and 10 wolves differentiated signatures resulting from domestication rather than breed formation. Read More

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June 2018
9 Reads

Assessing the accuracy of intracameral phenylephrine preparation in cataract surgery.

Eye (Lond) 2018 Oct 15;32(10):1615-1620. Epub 2018 Jun 15.

Tennent Institute of Ophthalmology, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0YN, UK.

Purpose: Unpreserved phenylephrine is often used as an off-licence intracameral surgical adjunct during cataract surgery to assist with pupil dilation and/or stabilise the iris in floppy iris syndrome. It can be delivered as a neat 0.2 ml bolus of either 2. Read More

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October 2018
1 Read

Thoracoscopic posterior tracheopexy during primary esophageal atresia repair: a new approach to prevent tracheomalacia complications.

J Pediatr Surg 2018 Jul 27;53(7):1420-1423. Epub 2018 Apr 27.

Department of Paediatric Surgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, 3508 AB Utrecht, The Netherlands.

Background: Esophageal atresia (EA) is usually accompanied by some form of tracheomalacia (TM). During the early phases in life, excessive dynamic collapse of the trachea can cause a wide spectrum of symptoms ranging from mild complaints to apparent life-threatening events (ALTE's) or brief resolved unexplained events (BRUE's). Therapeutic strategies for severe TM include aortopexy to lift the anterior weakened cartilaginous rings or posterior tracheopexy of the floppy membranous tracheal intrusion. Read More

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July 2018
2 Reads

Genome-wide association study reveals novel genes for the ear size in sheep (Ovis aries).

Anim Genet 2018 Aug 18;49(4):345-348. Epub 2018 May 18.

CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, 100101, China.

Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. Read More

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Effect of puckering motion and hydrogen bond formation on the vibrational circular dichroism spectrum of a flexible molecule: the case of (S)-1-indanol.

Phys Chem Chem Phys 2018 May;20(21):14635-14646

Institut des Sciences Moléculaires d'Orsay (ISMO), CNRS, Univ. Paris-Sud, Université Paris-Saclay, F-91405 Orsay, France.

The influence of flexibility and hydrogen bond formation on the IR absorption and vibrational circular dichroism (VCD) spectrum of a floppy protic molecule, namely, (S)-1-indanol, is studied in both non-polar CCl4 and polar DMSO solvents. The experimental IR absorption and VCD spectra obtained by Fourier transform spectroscopy are interpreted using both static density functional theory (DFT) calculations and first principles molecular dynamics (FPMD) within DFT, using the nuclear velocity perturbation theory (NVPT). Simulation of the spectra based on static optimised geometries is not sufficient in CCl4 and going beyond static calculations is mandatory for satisfactorily reproducing the VCD spectra. Read More

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Best Prophylactic Strategy in Groups at Risk of Intraoperative Floppy Iris Syndrome Development: Comparison Between Atropine Instillation and Adrenaline Intracameral Injection.

Open Ophthalmol J 2018 30;12:34-40. Epub 2018 Mar 30.

Eye Clinic Section and Specialization School in Ophthalmology, Institute of Ophthalmology, Department of Surgical Sciences, University of Turin, Turin, Italy.

Background: Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery. Read More

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March 2018
1 Read

Molecular dynamics study of tridymite.

IUCrJ 2018 May 17;5(Pt 3):325-334. Epub 2018 Apr 17.

Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, England.

Structural changes in tridymite have been investigated by molecular dynamics simulation. Two thermal processes were carried out, one cooling from the high-temperature hexagonal structure of tridymite (HP-tridymite) and the other heating from the low-temperature monoclinic structure of tridymite (MX1-tridymite). The former process showed that HP, LHP (low-temperature hexagonal structure), OC (orthorhombic structure with 222 symmetry) and OP (orthorhombic structure with 222 symmetry)-like structures appeared in sequence. Read More

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Ten years of intraoperative floppy iris syndrome in the era of α-blockers.

Cent European J Urol 2018 6;71(1):98-104. Epub 2017 Dec 6.

Hanusch Krankenhaus, Department of Urology, Vienna, Austria.

Introduction: The use of alpha-1 receptor antagonists in the treatment of benign prostatic hyperplasia (BPH) has created a problem in ophthalmic surgery, the so-called intraoperative floppy iris syndrome (IFIS). This consists of a billowing iris, insufficient pupillary dilation with progressive intraoperative miosis, and protrusion of iris tissue through the tunnel and side port incision that are made for access to the anterior chamber during surgery. IFIS presents particular difficulties in cataract surgery which is carried out through the pupil with manipulations in the immediate vicinity of the iris. Read More

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December 2017

Lax eyelid syndrome (LES), obstructive sleep apnea (OSA), and ocular surface inflammation.

Ocul Surf 2018 Jul 3;16(3):331-336. Epub 2018 May 3.

Department of Ophthalmology, Loyola University Medical Center, Maywood, IL, USA. Electronic address:

Purpose: Lax eyelid syndrome (LES) is defined as the association of distensible "floppy" eyelids and chronic papillary conjunctivitis. LES is also found in patients with obstructive sleep apnea (OSA) who have systemic elevation of inflammatory markers, including matrix metalloproteinases (MMP). Locally elevated MMP levels have also been demonstrated co-localized with elastin loss in eyelids of patients with LES, accounting for their "floppiness. Read More

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July 2018
12 Reads

An atomic-scale evaluation of the fracture toughness of silica glass.

J Phys Condens Matter 2018 Jun 4;30(24):245901. Epub 2018 May 4.

Mechanics of Materials Department, Sandia National Laboratories, PO Box 969, Livermore, CA 94551, United States of America.

Using an atomistic technique consistent with continuum balance laws and drawing on classical fracture mechanics theory, we estimate the resistance to fracture propagation of amorphous silica. We discuss correspondence and deviations from classical linear elastic fracture mechanics theory including size dependence, rigid/floppy modes of deformation, and the effects of surface energy and stress. Read More

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June 2018
1 Read

Floppy neonate with feeding difficulties.

Arch Dis Child Educ Pract Ed 2018 Apr 27. Epub 2018 Apr 27.

Department of Peds and Neonatology, Dr L H Hiranandani Hospital, Mumbai, Maharashtra, India.

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April 2018
7 Reads

Efficacy and safety of low-concentration, bisulphite-containing, intracameral epinephrine and topical atropine treatments for the prevention of intraoperative floppy iris syndrome.

Cutan Ocul Toxicol 2018 Sep 3;37(3):286-290. Epub 2018 May 3.

c Department of Ophthalmology , Marmara University School of Medicine , Istanbul , Turkey.

Purpose: The aim of this study was to evaluate the efficacy and safety of topical atropine and topical atropine combined with intracameral low-concentration, bisulphite-containing epinephrine treatment for the prophylaxis of intraoperative floppy iris syndrome.

Materials And Methods: Seventy-two eyes of 55 male patients who were treated with alpha-adrenergic antagonist medications for benign prostatic hyperplasia were included in this study. Standard premedication with topical cyclopentolate, phenylephrine, tropicamide and ketorolac was applied to all of the patients. Read More

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September 2018
4 Reads

What parents are reading about laryngomalacia: Quality and readability of internet resources on laryngomalacia.

Int J Pediatr Otorhinolaryngol 2018 May 28;108:175-179. Epub 2018 Feb 28.

Children's Hospital of Pittsburgh of UPMC, Division of Otolaryngology, 4401 Penn Avenue, Faculty Pavilion, 7th Floor, Pittsburgh, PA 15224, United States. Electronic address:

Objective: The goal of this study is to measure the quality and readability of websites related to laryngomalacia, and to compare the quality and readability scores for the sites accessed through the most popular search engines.

Introduction: Laryngomalacia is a common diagnosis in children but is often difficult for parents to comprehend. As information available on the internet is unregulated, the quality and readability of this information may vary. Read More

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May 2018
1 Read

Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.

Acc Chem Res 2018 Apr 29;51(4):960-969. Epub 2018 Mar 29.

Department of Chemistry , University at Buffalo, SUNY , Buffalo , New York 14260-3000 , United States.

The mystery associated with catalysis by what were once regarded as protein black boxes, diminished with the X-ray crystallographic determination of the three-dimensional structures of enzyme-substrate complexes. The report that several high-resolution X-ray crystal structures of orotidine 5'-monophosphate decarboxylase (OMPDC) failed to provide a consensus mechanism for enzyme-catalyzed decarboxylation of OMP to form uridine 5'-monophosphate, therefore, provoked a flurry of controversy. This controversy was fueled by the enormous 10-fold rate acceleration for this enzyme, which had " jolted many biochemists' assumptions about the catalytic potential of enzymes. Read More

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April 2018
1 Read

Clinical risk factors associated with intraoperative floppy iris syndrome: a prospective study.

Int Ophthalmol 2018 Mar 17. Epub 2018 Mar 17.

Department of Ophthalmology, Military Institute of Aviation Medicine, Krasińskiego 54/56, 01-755, Warsaw, Poland.

Purpose: To evaluate the incidence of and factors associated with intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract phacoemulsification.

Methods: In total, 319 eyes of 319 patients who underwent phacoemulsification with implantation of an intraocular lens (IOL) into the posterior chamber were included in this study. Direct injection of epinephrine into the anterior chamber was performed in all cases. Read More

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March 2018
13 Reads

Comprehensive Multimodality Imaging Review of Complications of Penile Prostheses.

AJR Am J Roentgenol 2018 Jun 12;210(6):1200-1207. Epub 2018 Mar 12.

7 Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Objective: The objective of our article is to review the role of imaging in the diagnosis of various complications of a penile prosthesis (PP).

Conclusion: Complications of a PP can be categorized into three groups: first, malpositioning, which includes buckling, floppy glans, erosion, migration, and crossover; second, mechanical failure, which includes fracture, aneurysm, and leakage; and, third, infection. Radiography, sonography, CT, and MRI are useful in the detection of these complications and complement each other, with MRI being the most useful imaging modality among them. Read More

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June 2018
2 Reads

Determinants of inappropriate hospitalization in cataract surgery in the south of Italy: a retrospective study.

Int Ophthalmol 2018 Mar 8. Epub 2018 Mar 8.

Department of Sciences for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, Via del Vespro 127, 90127, Palermo, Italy.

Purpose: To analyze the frequency of inappropriate hospitalization in cataract surgery and the type of related determinants.

Methods: A nested retrospective case-control study was carried out on 2708 consecutive cataract surgery patients operated between January 2013 and December 2015. All cases with inappropriate hospitalization (day surgery or ordinary hospitalization) were compared with a control group of cases treated in an appropriate (day service) regimen. Read More

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March 2018
6 Reads

Topological Edge Floppy Modes in Disordered Fiber Networks.

Phys Rev Lett 2018 Feb;120(6):068003

Department of Physics, University of Michigan, Ann Arbor, Michigan 48109-1040, USA.

Disordered fiber networks are ubiquitous in a broad range of natural (e.g., cytoskeleton) and manmade (e. Read More

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February 2018

Pulmonary Tumor Embolism Due to Squamous Cell Carcinoma of the Uterine Cervix: A Case Report.

In Vivo 2018 Mar-Apr;32(2):337-343

Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka, Japan

Background/aim: We report on a case of pulmonary tumor embolism caused by squamous cell carcinoma of the uterine cervix.

Patients And Methods: A 60-year-old female diagnosed with stage IVB (cT4N1M1) squamous cell carcinoma of the uterine cervix was admitted to our institution with a chief complaint of progressive dyspnea that developed within a few days after admission.

Results: A chest CT scan showed dilated pulmonary arteries, right ventricular enlargement and mosaic ground-glass opacities in both lungs. Read More

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August 2018
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Superficial punctate keratopathy in a pediatric patient was related to adenoid hypertrophy and obstructive sleep apnea syndrome: a case report.

BMC Ophthalmol 2018 Feb 23;18(1):55. Epub 2018 Feb 23.

Department of Ophthalmology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.

Background: Known causes of superficial punctuate keratopathy (SPK) in children include entropion, viral infection, blepharokeratoconjunctivitis (BKC), and toxicity of eye drops. However, there are some SPK patients whose causes could not be identified well. Herein, we describe the history, diagnosis, treatment, and prognosis of a rare case. Read More

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February 2018
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