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J Plast Reconstr Aesthet Surg 2020 May 19. Epub 2020 May 19.

Medical Faculty, Department of Plastic Reconstructive and Aesthetic Surgery, Erciyes University, Kayseri, Turkey. Electronic address:

To date, the surgical delay of skin flaps is the most common and reliable method that increases skin flap survival. In this study, we aimed to increase skin flap viability using preconditioning by microneedling. Seventy-two Sprague Dawley rats were randomly divided into control, surgical flap delay (SFD), and four microneedling groups (7 or 14 days of preconditioning with 0. Read More

Int Braz J Urol 2020 Apr 20;46. Epub 2020 Apr 20.

Department of Urology, Columbia University Medical Center, New York, NY, USA.

Objective: The objective is to summarize and characterize the long-term success of anterior augmentation urethroplasty (AU) in published series. The current literature on AU consists largely of retrospective series reporting intermediate follow-up and incompletely characterize the long term outcomes of AU.

Materials And Methods: A systematic literature review was performed consistent with PRISMA guidelines to characterize long-term outcomes of AU with a minimum upper limit follow-up of 100 months. Read More

Br J Oral Maxillofac Surg 2020 May 20. Epub 2020 May 20.

Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology, No. 1 Da-Hua Road, Beijing 100730, China. Electronic address:

Trans-territory perforator flaps are commonly used to reconstruct large defects of the soft tissues. The distal portion of the flap often becomes necrotic, however, as a result of the jeopardised vasculature of choke zone II. The trophic and vascular regenerative properties of bone marrow mesenchymal stem cells (BMSC) seemed to be a promising approach to prevent flaps becoming ischaemic. Read More

Ann Burns Fire Disasters 2019 Dec;32(4):294-300

National Burns Hospital, Hanoi, Vietnam.

Radiation-induced ulcers are a late-stage skin reaction after radiation therapy for cancer treatment. The present study examined the possibility of using a single-stage reconstructive procedure to manage radiation-related wounds. This prospective study recruited 30 participants who underwent radiation treatment for cancer or hemangioma. Read More

Adv Sci (Weinh) 2020 May 1;7(9):1903553. Epub 2020 Mar 1.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. China.

The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying-driven curling of apple peels, hydrogel-based micro-scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y-branches, anastomosis rings, and triangle loops. Read More

J Plast Surg Hand Surg 2020 Apr 24:1-8. Epub 2020 Apr 24.

Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Ischemic necrosis has been most dreaded complication of flap reconstruction. Therefore, researchers have tried to improvise modalities to prevent or treat it since the onset of flap surgery. So far these researches have failed to identify a pharmacological therapy equally effective as surgical delay in augmenting skin flap viability. Read More

J Craniofac Surg 2020 Mar 20. Epub 2020 Mar 20.

Ex-Head Division Plastic Surgery, Argerich Hospital Ciudad Autonoma de Buenos Aires, Educational Plastic Surgery Unity, Medicine Faculty Buenos Aires University, Buenos Aires, Argentina.

The use of fasciocutaneous flaps remain as first election of reconstructive method after remotion of tumors, benign lesions and sequel of traumas.A new designed fasciocutaneous flap according to mechanism V-Y like island flap is described. It has 2 different portions: 1. Read More

World J Plast Surg 2020 Jan;9(1):55-61

Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Hidradenitis suppurativa is a chronic inflammatory disease with multiple inflammatory nodules and abscesses. We aimed to compare split thickness skin graft (STSG) and flaps in bilateral chronic refractory axillary hidradenitis suppurativa.

Methods: Thirty patients were investigated from March 21, 2010 to March 20, 2015. Read More

World J Plast Surg 2020 Jan;9(1):48-54

Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Background: Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps. Read More

Sci Rep 2020 Feb 21;10(1):3212. Epub 2020 Feb 21.

Podiatric Surgery, UC Heath, Cincinnati, USA.

Smoking aggravates skin necrosis as a complication of random-pattern flap ischaemia. Sildenafil and nitroglycerin (NTG) are vasodilator agents that may affect skin flap survival. Fifty rats were subjected to a dorsal random-pattern flap operation and randomly divided into 5 groups. Read More

Ophthalmic Plast Reconstr Surg 2020 Feb 7. Epub 2020 Feb 7.

Department of Ophthalmology and.

Purpose: The aim of this study was to investigate how the blood perfusion in human upper eyelid skin flaps is affected by the length of the flap and the degree of stretching and rotation of the flap.

Methods: Twenty-nine upper eyelids were dissected as part of a blepharoplastic procedure in patients. The 1-cm wide proximal end of the flap remains attached, to mimic a random pattern skin flap (hereafter called a "skin flap"). Read More

J Plast Reconstr Aesthet Surg 2020 May 28;73(5):913-920. Epub 2019 Nov 28.

Department of Surgery, The Christie NHS Foundation Trust, Manchester M20 4BX, UK; Institute of Cancer Studies, University of Manchester, UK. Electronic address:

Background/aims: Oncological skin defects of the extremities and trunk can be challenging. Our modified bipedicled flap utilises the principle of the bipedicled advancement flap, but allows for direct closure of the donor site (as opposed to skin grafting). It does not rely on the preservation of perforators and it random pattern, making it extremely versatile. Read More

J Plast Reconstr Aesthet Surg 2020 May 28;73(5):975-982. Epub 2019 Nov 28.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, Shanxi Province 710032, People's Republic of China. Electronic address:

Background: Management of avulsion injuries remains a challenge due to necrosis. The aim of the present study is to create an experimental model reproducing an avulsion injury and investigate the effects of hyperoxygenated solution (HOS), a method of oxygen delivery that has been widely used in the therapy of ischaemia-hypoxia diseases, on avulsion injury flap survival in rats.

Methods: Forty male rats were divided into four groups (n = 10 each). Read More

Am J Transl Res 2019 15;11(11):7063-7073. Epub 2019 Nov 15.

Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University NO. 109, Xueyuan West Road, Luheng District, Wenzhou 325000, Zhejiang Province, P. R. China.

Purpose: To determine if the viability of random pattern dorsal skin flaps in rats could be improved with local injection of exosomes derived from bone marrow mesenchymal stem cells (BMSCs).

Methods: 30 adult male SD rats (weight 200-250 g) were randomly divided into experimental and control groups. Exosomes were isolated from the 4th generation of BMSCs. Read More

Int Immunopharmacol 2020 Jan 3;78:106010. Epub 2019 Dec 3.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xue Yuan Xi Road, Wenzhou, Zhejiang, China. Electronic address:

Random-pattern flap necrosis is a serious challenge for plastic surgeons. Nobiletin (NOB) is a polymethoxylated flavonoid extracted from citrus fruits reported to have antioxidant, anti-inflammatory and anti-apoptotic effects. Our experiment evaluated the impact of NOB on the viability of random flaps. Read More

Ann Plast Surg 2020 May;84(5):588-594

From the Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery.

Background: Dickkopf 2 (DKK2) has important roles in vertebrate development; it inhibits Wnt signaling-related processes, such as axial patterning, limb development, somitogenesis, and eye formation. However, DKK2 also acts as a Wnt signaling agonist. Dickkopf 2, induced during endothelial cell morphogenesis, promotes angiogenesis in cultured human endothelial cells. Read More

J Plast Reconstr Aesthet Surg 2020 Mar 10;73(3):598-607. Epub 2019 Oct 10.

School of Medicine, National Yang Ming University, Division of Plastic Surgery, Taipei Veterans General Hospital, and Department of Surgery, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Background: Skin flap necrosis is a common postoperative complication in reconstructive surgery. Recent evidence suggests that subcutaneously injected adipose-derived stem cells (ASCs) increase the viability of random skin flaps. Here, we examined whether intra-arterial human ASC administration could improve random component survival of axial skin flaps in nude mice. Read More

Cell Death Dis 2019 11 18;10(12):872. Epub 2019 Nov 18.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.

Random-pattern skin flap is commonly used for surgical tissue reconstruction due to its ease and lack of axial vascular limitation. However, ischemic necrosis is a common complication, especially in distal parts of skin flaps. Previous studies have shown that FGF21 can promote angiogenesis and protect against ischemic cardiovascular disease, but little is known about the effect of FGF21 on flap survival. Read More

Adv Wound Care (New Rochelle) 2019 Jul 2;8(7):281-290. Epub 2019 Jul 2.

Department of Plastic and Reconstructive Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Skin flaps are routinely used in reconstructive surgery yet remain susceptible to ischemia and necrosis. Distant flaps require lengthy time to detach causing patient discomfort. Human α1-antitrypsin (hAAT) is a clinically available serum glycoprotein. Read More

J Photochem Photobiol B 2019 Dec 17;201:111634. Epub 2019 Oct 17.

Federal University of São Carlos, São Carlos, São Paulo, Brazil; Brasil University - São Paulo, São Paulo, Brazil; University of Araraquara, Araraquara, São Paulo, Brazil.

Skin Flap is used in reconstructive plastic surgery. However, complications such as ischemia followed by local necrosis may occur, requiring a new surgical procedure. It is well known that photobiomodulation therapy (PBMT) is an effective technique for improving microcirculation and neoangiogenesis, which contributes positively to the blood supply in the pre and post surgical period. Read More

J Craniofac Surg 2020 Jan/Feb;31(1):107-109

Universidad Autónoma de Guadalajara, Guadalajara, México.

Background: The full creation of an ear requires 2 reconstruction stages. In the second stage of reconstruction, the cartilaginous framework placed at first stage is separated from the head creating an auriculocephalic sulcus. Then a piece of rib cartilage is placed in the sulcus to maintain this separation and is covered with tissue that allows the integration of a full-thickness skin graft. Read More

Ann Plast Surg 2020 02;84(2):208-215

From the Plastic, Reconstructive and Aesthetic Surgery Clinic.

Background: Skin flaps are the first-line treatment modality for skin defect reconstruction. With the increased importance and use of flap surgery, a growing number of studies have investigated the ways for the prevention of ischemia-reperfusion injury. The aim of this study was to investigate the effect of astaxanthin, which is an antioxidant molecule from the xanthophyll family, on the survival of random pattern skin flaps. Read More

J Surg Res 2020 02 17;246:519-526. Epub 2019 Oct 17.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Sodium valproate interacts with biological systems through different mechanisms such as activation of gamma-aminobutyric acid (GABA)-sensitive chloride channels and inhibition of histone deacetylase. In this study, we examined the effect of sodium valproate in random-pattern skin flap of rats and investigated its mechanisms of action. Different types of experiments were carried out. Read More

Ann Plast Surg 2020 03;84(3):276-282

From the Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany.

Background: Early reconstruction of burn sequelae of the hand can be challenging owing to high goals for functional and aesthetic outcome. A variety of reconstructive procedures with ascending levels of complexity exists and warrants careful indication.

Methods: In this case series, the main reconstructive techniques for reconstruction of burn defects of the hand are described, illustrated, and discussed: split thickness skin grafting (STSG) with fibrin glue, dermal matrices with STSG, distant random pattern (abdominal bridge) flap, distant pedicled flap (superficial circumflex iliac artery flap), and free microvascular tissue transfer (anterolateral thigh flap). Read More

Zhonghua Shao Shang Za Zhi 2019 Sep;35(9):683-689

Department of Burns and Plastic Surgery, the 909th Hospital of PLA (Affiliated Southeast Hospital of Xiamen University), Zhangzhou 363000, China.

To explore the effects of autologous platelet-rich plasma (PRP) in the repair of soft tissue defects of rabbits with free flap. Thirty 6-month-old New Zealand white rabbits, male and female unlimited, were used to harvest blood from the heart. PRP was prepared by Aghaloo method, then free flap model with size of 5 cm×3 cm was reproduced on each ear of the rabbit. Read More

Zhonghua Shao Shang Za Zhi 2019 Sep;35(9):661-667

Department of Cosmetic Surgery, Guangzhou Minghan Aesthetic Hospital, Guangzhou 510623, China.

To explore the clinical effects and key techniques of expanded super-thin perforator flaps in the shoulder, neck, and chest in reconstruction of extensive burn scars in the face. From January 2008 to November 2018, 22 patients with extensive burn scars in the face were admitted to the Department of Plastic Surgery of Dongguan Kanghua Hospital and the Department of Plastic Surgery of Dermatology Hospital of Southern Medical University, with 3 males and 19 females, aged from 4 to 48 years. There were 16 cases of type Ⅱ and 6 cases of type Ⅲ in facial scars. Read More

Front Pharmacol 2019 13;10:1017. Epub 2019 Sep 13.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. Read More

Cell Death Dis 2019 09 15;10(7):483. Epub 2019 Sep 15.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.

Random-pattern skin flaps are commonly used and valuable tools in reconstructive surgery, however, post-operative random skin flap necrosis remains a major and common complication. Previous studies have suggested that activating autophagy, a major pathway for degradation of intracellular waste, may improve flap survival. In this study, we investigated whether trehalose, a novel and potent autophagy activator, improves random skin flap viability. Read More

Ann Plast Surg 2020 May;84(5):575-579

Neurosurgery, Faculty of Medicine, Qena University Hospital, South Valley University, Qena, Egypt.

Background: Reconstruction of the skin defect after myelomeningocele repair is a crucial step that influences the quality of the surgical outcome. Keystone perforator flap is an islanded fasciocutaneous flap based on random regional perforators, which is advanced to adjacent defects. It has become a reliable method of locoregional reconstruction in various body parts with minimum morbidity. Read More

J Mater Sci Mater Med 2019 Sep 9;30(9):106. Epub 2019 Sep 9.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, China.

With the advantage of handy process, random pattern skin flaps are generally applied in limb reconstruction and wound repair. Apelin-13 is a discovered endogenous peptide, that has been shown to have potent multiple biological functions. Recently, thermosensitive gel-forming systems have gained increasing attention as wound dressings due to their advantages. Read More

Laryngorhinootologie 2019 Sep 9;98(9):608-611. Epub 2019 Sep 9.

Klinik und Poliklinik für Dermatologie und Allergologie, Hauttumorzentrum, Abteilung für Dermatochirurgie, Technische Universität München.

Classic transposition flaps (TF) consist of a single random pattern lobe, which is elevated (rotated) over an area of normal skin to reach the primary defect. Frequently mentioned modifications are the rhombic flaps according to Limberg and Dufourmentel as well as the unilateral multi lobed ("bilobed" and "trilobed") flaps 1, 2, 3, 4, 5, 6. The contralateral double TF presented here is a modification rarely mentioned in the literature 4. Read More

Int Immunopharmacol 2019 Nov 6;76:105875. Epub 2019 Sep 6.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Random flaps are commonly used to repair wounds and improve the clinical appearance. However, flap necrosis is frequently encountered in the clinical setting. Adiponectin is a biologically active endogenous polypeptide secreted by adipocytes that can reduce oxidative stress, inflammation, and apoptosis. Read More

Int Wound J 2019 Dec 5;16(6):1471-1476. Epub 2019 Sep 5.

Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

One of the most severe complications in aesthetic and reconstructive surgeries is the partial or total necrosis of a skin flap. In our experimental study, we demonstrated the use of adipose-derived stem cells in the increase of skin flap survival rates. Stem cells were isolated from the fat of Wistar rats and genetically modified to permanently produce a green fluorescent protein (GFP). Read More

Arch Craniofac Surg 2019 Aug 20;20(4):239-245. Epub 2019 Aug 20.

Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine, Daegu, Korea.

Background: Lidocaine spray is a local anesthetic that improves random-pattern skin flap survival. The fractional ablative carbon dioxide laser (FxCL) produces vertical microchannels that delivers topically applied drugs to the skin. In this study, we hypothesized that FxCL therapy would enhance the lidocaine effect to improve random-pattern skin flap survival in rats. Read More

Eur J Pharmacol 2019 Oct 8;861:172600. Epub 2019 Aug 8.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China. Electronic address:

This study was performed to examine the protective effects of icariin (ICA) on ischemic random skin flaps. A rat random-pattern skin flap model was established, and animals in the low-dose and high-dose experimental groups were administered ICA intraperitoneally at doses of 40 and 80 mg/kg, respectively, once daily for 7 days after the initial surgery. Control rats received vehicle according to the same schedule. Read More

Zhonghua Shao Shang Za Zhi 2019 Jul;35(7):481-485

Department of Burns and Plastic Surgery, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China.

In 600 BC, the first pedicled direct cutaneous artery perforator flap-the supravicular artery perforator flap was harvested by Sushruta. In 1973, the first free perforator flap-the superficial circumflex iliac artery flap in the groin was reported by Daniel and Taylor. In 1982, the septocutaneous perforator flap was reported by academician Zhong Shizhen. Read More

Int Immunopharmacol 2019 Sep 9;74:105720. Epub 2019 Jul 9.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China. Electronic address:

Objective: This study explored the effects of urinary kallidinogenase (UK) on ischemia and necrosis of random skin flaps in rats, and the mechanisms thereof.

Methodology: Ischemia and necrosis of random skin flaps were induced by constructing a modified McFarlane flap model on the dorsa of rats. UK (0. Read More

Plast Reconstr Surg 2019 07;144(1):70e-77e

Tehran, Iran; and Dallas, Texas From the School of Medicine, the Experimental Medicine Research Center, School of Public Health, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, the Department of Pathology, Dr. Shariati Hospital, and the Department of Pharmacology, Tehran University of Medical Sciences; and the Department of Plastic and Reconstructive Surgery, University of Texas Southwestern Medical Center.

Background: Random pattern skin flaps are applicable for reconstructing any defect in plastic surgery. However, they are difficult to apply because of necrosis. Sumatriptan, a selective 5-hydroxytryptamine 1b/1d agonist, is routinely used to offset acute migraine attacks. Read More

Drug Des Devel Ther 2019 29;13:1865. Epub 2019 May 29.

Hand (N Y) 2019 Jun 3:1558944719851166. Epub 2019 Jun 3.

1 Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: The management of combined defects of the dorsum of the hand and the thumb can be quite challenging. The conventional teaching has been to use more than 1 flap for such discontinuous defects of the hand.

Methods: We present a novel technique to provide a reliable skin cover to a concomitant second defect over thumb, which otherwise would require an additional flap, by recruiting the excess skin available after closure of the primary flap donor site of the hypogastric flap being used for the defect on the dorsum of hand. Read More

J Cell Biochem 2019 10 24;120(10):17491-17499. Epub 2019 May 24.

Price Institute of Surgical Research, University of Louisville, Louisville, Kentucky.

Random skin flaps (RSFs) are cutaneous flaps. Despite the negative impact of diabetes mellitus (DM) on RSF viability, they are commonly used in diabetic patients. In this study, we have assessed bone marrow mesenchymal stem cell (BMMSC) treatment on RSF survival, tensiometrical parameters, angiogenesis, and mast cells (MCs) count in an ischemic RSF model in rats with type 1 DM (T1DM). Read More

Drug Des Devel Ther 2019 1;13:1461-1472. Epub 2019 May 1.

The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.

Random skin flap is frequently used in plastic and reconstructive surgery, but its distal part often occurs ischemia and necrosis. Pravastatin (Prava) with bioactivities of pro-angiogenesis, anti-apoptosis and anti-oxidative stress, may be beneficial for flap survival. A modified McFarlane flap model was performed in Sprague-Dawley rats. Read More

Arch Plast Surg 2019 May 15;46(3):214-220. Epub 2019 May 15.

Department of Plastic, Aesthetic, and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Background: Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea (Camellia sinensis). Read More

Zhonghua Shao Shang Za Zhi 2019 Apr;35(4):311-313

Department of Burns and Plastic Surgery, Beijing Fengtai You'anmen Hospital, Beijing 100069, China.

Ten patients with perianal necrotizing fasciitis were admitted to our department from June to December 2016. There were 8 men and 2 women among the patients, aged 42 to 69 years. Early and complete debridement surgery and comprehensive supportive treatment during perioperative period were carried out to quickly stabilize the patient's overall condition, and wounds were sutured directly or repaired with autologous scalps and or adjacent local random flaps. Read More

Int Immunopharmacol 2019 Jul 16;72:235-242. Epub 2019 Apr 16.

Department of Hand Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, China. Electronic address:

Objective: Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model.

Materials And Methods: Dorsal McFarlane flaps were harvested from 36 rats divided into two groups. Read More

Aesthet Surg J 2019 11;39(12):NP504-NP514

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, China.

Background: Adipose tissue and its derivatives, including adipose-derived stem cells, stromal vascular fraction (SVF), and SVF-gel, have been utilized in the treatment of many ischemic disorders. However, the utilization of these products is limited in clinical applications by concerns related to the presence of cells in these derivatives.

Objectives: This study aimed to isolate a cell-free fat extract (FE) from fat tissue and to evaluate its proangiogenic ability in vitro as well as its protective effects on skin flap survival in vivo. Read More

Am J Transl Res 2019 15;11(3):1403-1416. Epub 2019 Mar 15.

Department of Burns Surgery, First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China.

A random skin flap is commonly applied in plastic and reconstructive surgery. The distal part of the random skin flap often risks necrosis because the blood flow may be compromised. Prevascularization is a widely used technology to intensify the vascularization function of biomaterials. Read More

J Plast Surg Hand Surg 2019 Aug 31;53(4):247-253. Epub 2019 Mar 31.

a Department of Plastic and Reconstructive Surgery, University of Health Sciences, Istanbul Training and Research Hospital , Istanbul , Turkey.

One of the simplest form of surgical delay can be performed by placing an incision around the flap without undermining, prior to flap elevation. In this study, we have compared the efficiency of different patterns of skin incision to improve flap survival. Twenty-eight animals were used in four groups. Read More

J Invest Surg 2019 Mar 21:1-11. Epub 2019 Mar 21.

a Department of Orthopedics , People's Hospital of YingDe City Guangdong Province , Yingde City , China.

Background: Asiaticoside (AS) is extracted from the traditional herbal medicine Centella asiatica, and has angiogenic, antioxidant, anti-inflammatory, and wound-healing effects. We investigated the effects of AS on skin flap survival.

Methods: Dorsal McFarlane flaps were harvested from 36 rats and divided into two groups: an experimental group treated with 40 mg/kg AS administered orally once daily, and a control group administered normal saline in an identical manner. Read More

J Plast Surg Hand Surg 2019 Aug 19;53(4):198-203. Epub 2019 Mar 19.

e Department of Nuclear Medicine, School of Medicine, Gaziantep University , Gaziantep , Turkey.

The aim of this study was to show whether the protective effect of remote ischemic preconditioning (RIPC) on flaps can be transferred among different individuals with the transfusion of blood serum. Blood serum was taken from rats without any procedure (Group x), rats 1 hour (Group y) and 24 hours (Group z) after performing RIPC and the remaining rats were divided into six groups. While the random pattern skin flap was performed only in the back region in Group 1, and it was performed 1 hour (Group 2) and 24 hours (Group 3) after induction RIPC. Read More