Search Our Scientific Publications & Authors

Commun Biol 2022 Jun 22;5(1):616. Epub 2022 Jun 22.

Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China.

The random-pattern skin flap is a crucial technique in reconstructive surgery and flap necrosis caused by ischemia/reperfusion injury is a major postoperative complication. Herein, we investigated the mechanism of mitophagy induced by Melatonin (ML) and its effect on the survival of skin flaps. Our results demonstrated that ML could activate mitophagy, ameliorate oxidative stress and alleviate apoptosis in Tert-Butyl hydroperoxide solution (TBHP)-stimulated human umbilical vein endothelial cells in vitro. Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Metro Manila, Philippines.

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0. Read More

Aesthetic Plast Surg 2022 Jun 17. Epub 2022 Jun 17.

Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Background: Partial necrosis of skin flaps following plastic and reconstructive surgeries is one of the major problems in these medical interventions. This study was conducted to evaluate the beneficial effects of topiramate an anti-epileptic agent on ischemic random skin flaps.

Materials And Methods: Twenty-four Wistar rats were provided and randomly divided into four experimental groups (control group and low-, intermediate- and high-dose treatment groups). Read More

Front Pharmacol 2022 19;13:901498. Epub 2022 May 19.

Department of Orthopaedics, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random-pattern skin flap is widely used in plastic and reconstructive surgery. However, its clinical effect is limited by ischemia necrosis occurs at the distal part of flap. Previous studies have proved that the protective effect of formononetin was associated with its antioxidant, anti-inflammatory ability. Read More

Adv Sci (Weinh) 2022 Jun 2:e2201155. Epub 2022 Jun 2.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.

Biological scaffolds hold promising perspectives for random skin flap regeneration, while the practical application is greatly limited by their insufficient vascularization ability and the lack of responsiveness during the dynamical healing process. Herein, a novel MXene-incorporated hollow fibrous (MX-HF) scaffold with dynamically responsive channels is presented for promoting vascularization and skin flap regeneration by using a microfluidic-assisted 3D printing strategy. Benefiting from the photothermal conversion capacity of the MXene nanosheets and temperature-responsive ability of poly(NIPAM) hydrogels in the MX-HF scaffolds, they display a near-infrared (NIR)-responsive shrinkage/swelling behavior, which facilitates the cell penetration into the scaffold channels from the surrounding environment. Read More

Oxid Med Cell Longev 2022 17;2022:5668226. Epub 2022 May 17.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Random-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect against ischemic cerebral disease. Read More

Cleft Palate Craniofac J 2022 Apr 21:10556656221095389. Epub 2022 Apr 21.

Department of Plastic and Reconstructive Surgery, 13753Yamaguchi Prefectural Grand Medical Center, Hofu, Japan.

One of the most common complications of total auricular reconstruction is exposure of the ear framework. Various reconstruction methods have been reported depending on the location and size of exposed cartilage. This report describes a safe reconstruction method for each exposed part of the grafted ear framework. Read More

Handchir Mikrochir Plast Chir 2022 Apr 14;54(2):139-148. Epub 2022 Mar 14.

BG Unfallklinik Ludwigshafen Klinik für Hand-, Plastische und Rekonstruktive Chirurgie, Mikrochirurgie, Schwerbrandverletztenzentrum, Plastische Chirurgie und Handchirurgie der Universität Heidelberg.

Introduction: Besides fasciocutaneous workhorse flaps, free muscle flaps for the reconstruction of large soft tissue defects are well-established standard microsurgical procedures. Random-pattern adipocutaneous skin paddles are often included for postoperative perfusion monitoring of the muscle flap. At our institution, both conventional broad-based and perforator-based adipocutaneous skin paddles are used. Read More

J Pers Med 2022 Feb 8;12(2). Epub 2022 Feb 8.

Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg FAU, 91054 Erlangen, Germany.

Background: Assessment of tissue perfusion after irradiation of random pattern flaps still remains a challenge.

Methods: Twenty-five rats received harvesting of bilateral random pattern fasciocutaneous flaps. Group 1 served as nonirradiated control group. Read More

J Plast Surg Hand Surg 2022 Feb 23:1-10. Epub 2022 Feb 23.

Department of Oral & Maxillofacial Surgery, Aristotle University of Thessaloniki, R.G.H. "George Papanikolaou", Exohi, Thessaloniki, Greece.

Flap necrosis on random pattern skin flaps continues to be a challenge. In this study, we evaluated whether topical application of a vasodilator substance (the prostaglandin PGI analogue, Iloprost, in cream form) as pre-treatment, would increase blood flow and improve flap viability. Wistar rats randomly allocated into four groups with 7 rats per group and two flaps 4cm × 2cm in the same rat i. Read More

Surg J (N Y) 2022 Jan 3;8(1):e56-e59. Epub 2022 Feb 3.

Department of General Surgery, L. N. Medical College and J. K. Hospital, Bhopal, Madhya Pradesh, India.

Reconstruction of full-thickness eyelid defects is done to provide a mobile lid with corneal protection, having good aesthetic quality, and acceptable donor site morbidity. Various flap procedures have been described and used for the lower eyelid reconstruction; however, the nasolabial flap is rarely employed. It is a random pattern cutaneous flap with redundant blood supply from the perforating branches of the facial and angular arteries and can be used as an inferiorly or superiorly based flap. Read More

Front Pharmacol 2021 21;12:818907. Epub 2022 Jan 21.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random skin flaps are frequently used to repair skin damage. However, the ischemic and hypoxic necrosis limits their wider application. Rivastigmine, a carbamate cholinesterase inhibitor (ChEI), has also been shown to reduce ischemia-reperfusion injury (IRI) and inflammation. Read More

Int Immunopharmacol 2022 Apr 29;105:108562. Epub 2022 Jan 29.

Department of Hand Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address:

Background: Distal ischemic necrosisis a common complication of orthopedic random skin flaps surgery. Paeoniflorin, a natural compound extracted from Paeonia lactiflora, can enhances angiogenesis and alleviates excessive inflammatory response. We investigated the changes of ischemic extra-long flaps with paeoniflorin and its possible mechanism. Read More

Plast Reconstr Surg 2022 Mar;149(3):629-637

From the Duke University School of Medicine; and Division of Plastic, Maxillofacial, and Oral Surgery and Department of Biomedical Engineering, Duke University.

Background: Surgical delay is a well-described technique to improve survival of random and pedicled cutaneous flaps. The aim of this study was to test the topical agents minoxidil and iloprost as agents of pharmacologic delay to induce vascular remodeling and decrease overall flap necrosis as an alternative to surgical delay.

Methods: Seven groups were studied (n = 8 in each group), including the following: vehicle, iloprost, or minoxidil before treatment only; vehicle, iloprost, or minoxidil before and after treatment; and a standard surgical delay group as a positive control. Read More

Lasers Med Sci 2022 Apr 11;37(3):1495-1501. Epub 2022 Jan 11.

Discipline of Experimental Surgery and Operative Technique, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

The aim of this study was to investigate the effect of red laser (660 nm) photobiomodulation (PBM) with different energies on tumor necrosis factor-alpha(TNF-α) expression for random skin flap viability in rats. Twenty-four Wistar rats were divided into three groups: sham group (SG), PBM laser group with an energy dose of 0.29 J (0. Read More

J Invest Surg 2022 May 10;35(5):1036-1043. Epub 2022 Jan 10.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, NO.127 Changle West Road, Xi'an, 710032, Shaanxi Province, P. R. China.

Poor blood supply can easily lead to expander extrusion and necrosis at the distal expanded flap. Botulinum toxin A (BTX-A) has been previously found to improve pedicled flap blood flow perfusion, but its effects on the blood supply of expanded skin remain unclear. Therefore, this study aimed to evaluate the effects of BTX-A on blood flow perfusion during and after expansion. Read More

World J Clin Cases 2021 Nov;9(33):10328-10336

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Total pharyngo-laryngo-esophagectomy with a reconstruction of gastric pull-up is the most common treatment method for patients with multiple primary upper digestive tract carcinomas, such as hypopharyngeal carcinoma with thoracic esophageal carcinoma. However, neck circumferential defect and tracheoesophageal fistula after gastric necrosis are still challenging problems for surgeons and patients.

Case Summary: This case report presents 2 patients who underwent reconstructive surgeries using 4 local random flaps with a split thickness skin graft in the first case, and 6 local random flaps in the second case to close the circumferential defect and tracheoesophageal fistula after failed gastric pull-up. Read More

Autophagy 2021 Dec 7:1-23. Epub 2021 Dec 7.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Necrosis that appears at the ischemic distal end of random-pattern skin flaps increases the pain and economic burden of patients. Necroptosis is thought to contribute to flap necrosis. Lysosomal membrane permeabilization (LMP) plays an indispensable role in the regulation of necroptosis. Read More

Front Bioeng Biotechnol 2021 19;9:771066. Epub 2021 Nov 19.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random flaps are widely used in tissue reconstruction, attributed to the lack of vascular axial limitation. Nevertheless, the distal end of the flap is prone to necrosis due to the lack of blood supply. Notoginseng triterpenes (NTs) are the active components extracted from , reducing oxygen consumption and improving the body's tolerance to hypoxia. Read More

Zhonghua Shao Shang Za Zhi 2021 Dec;37(12):1130-1136

Department of Burns, Zhengzhou First People's Hospital, Zhengzhou 450004, China.

To explore the clinical effects of artificial dermis combined with split-thickness skin for repairing wounds with bone and tendon exposure in hands and feet. A prospective randomized controlled study was conducted. From October 2018 to February 2020, 82 patients with bone and tendon exposed wounds in hands and feet admitted to the Department of Burns of Zhengzhou First People's Hospital who met the inclusion criteria were selected. Read More

Acta Cir Bras 2021 8;36(9):e360906. Epub 2021 Nov 8.

PhD, Full Professor. Division of Surgical Techniques and Experimental Surgery - Department of Surgery - Universidade Federal de São Paulo (UNIFESP) - Sao Paulo (SP), Brazil.

Purpose: To evaluate the effect of hyperbaric oxygenation (HBO) on angiogenesis in random rat skin flaps, by immunoexpression of vascular endothelial growth factor A (VEGF-A).

Methods: Forty adult rats were divided into four groups: GE) epilated; GE/HBO) epilated subjected to HBO; GER) epilated submitted to dorsal skin flap; GER/HBO) epilated subjected to dorsal skin flap + HBO. HBO was performed with rats inside a chamber under atmosphere close to 100% oxygen and pressure of 2. Read More

Ann Vasc Surg 2022 Mar 21;80:120-129. Epub 2021 Oct 21.

Department of Medicine (Nephrology Division) Command Hospital Udhampur, J & K, India.. Electronic address:

Objective: To highlight safety and efficacy of sine wave technique (SWT) in superficializing deep arterio venous fistula (AVF) and managing infiltrations and other complications.

Methods: It is a single center observational study done from Jul 2017 to July 2020. All successive cases of deep AVFs, aneurysm / pseudoaneurysms of AVFs, and AVFs requiring open venoplasty were managed with SWT. Read More

Microsurgery 2022 Mar 20;42(3):277-281. Epub 2021 Oct 20.

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.

Since the introduction of the angiosome concept, many attempts have been made to push the dimensional limits of free tissue transfers. While initially limited by the boundaries of random vascularization of adjacent angiosomes, wider flaps were transferred by combining contiguous source vessels. Combined flaps, either chimeric or conjoined, represent nowadays the largest reconstructive options in the human body. Read More

Br J Pharmacol 2022 01 14;179(2):301-321. Epub 2021 Dec 14.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Background And Purpose: Necrosis of random-pattern skin flaps limits their clinical application. Helix B surface peptide (HBSP) protects tissues from ischaemia-reperfusion injury but its short plasma half-life limits its applications. Here, we have synthesized cyclic helix B peptide (CHBP) and investigated its role in flap survival and the underlying mechanisms. Read More

Plast Reconstr Surg 2021 Oct;148(4):799-807

From the Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, and Department of Plastic and Reconstructive Surgery, Sapporo Medical University School of Medicine; Department of Plastic and Reconstructive Surgery, Medical University of Vienna; Department of Neurology, Yale University School of Medicine; and Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System.

Background: Surgical reconstruction options of soft-tissue defects often include random pattern skin flaps. Flap survival depends on flap size and rotation arc and can be challenging regarding flap perfusion, leading to wound healing complications, insufficient wound coverage, and even flap loss. Therefore, novel approaches that promote skin flap survival are required. Read More

Biomed Pharmacother 2021 Nov 10;143:112163. Epub 2021 Sep 10.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Skin flap transplantation is a common wound repair method in orthopedic surgery, but skin flap necrosis remains problematic. Memantine, an excitatory amino acid receptor antagonist, is currently used in the treatment of moderate to severe Alzheimer's disease, due to its ability to promote angiogenesis and reduce oxidative stress. This study investigated the effect of memantine on the survival of random skin flaps in Sprague-Dawley (SD) rats. Read More

Dermatol Surg 2021 11;47(11):1427

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

J Craniofac Surg 2022 May 29;33(3):913-915. Epub 2021 Jul 29.

Department of Plastic and Reconstructive Surgery and Maxillofacial Surgery, Kurume University School of Medicine.

Abstract: Following a tracheostomy or tracheal fenestration procedure, neck concave deformity, and contracture after spontaneous closure are common problems. Since the neck is an exposed part of the body, its concave deformity can cause cosmetic problems and functional problems such as difficulty in neck extension and swallowing due to contracture. We report the case of a 63-year-old man who underwent tracheal fenestration for worsening respiratory status due to sepsis after aspiration pneumonia. Read More

Dermatol Surg 2021 11;47(11):1421-1426

All authors are affiliated with the Dermatological Surgery Unit, Department of Dermatology, Coimbra University Hospital Centre, Coimbra, Portugal.

Background: The viability of random skin flaps (RSFs) depends on an adequate perfusion pressure to avoid necrosis. Laser speckle contrast imaging is a new method to monitor skin flap microcirculation.

Objective: The authors aimed to use laser speckle contrast imaging in evaluating the correlation between the perfusion pressure and the length-to-width ratio (LTWR) of RSFs. Read More

World J Plast Surg 2021 May;10(2):76-81

Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran.

Background: Randomized skin flaps have been used as a basic treatment modality for covering skin defects for a long time but they have always been in the risk of an inherent ischemia. Fibroblast growth factor 1 is a known angiogenic factor in in vitro studies which has shown conflicting results in in vivo investigation. We aimed to determine the effect of recombinant fibroblast growth factor on the angiogenesis rate of random cutaneous flap in animal model of rats. Read More