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    964 results match your criteria Fixed Drug Eruptions

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    Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis.
    Int Arch Allergy Immunol 2018 Apr 3. Epub 2018 Apr 3.
    Background: Acetaminophen is the most commonly used antipyretic in children. However, there are limited data assessing hypersensitivity reactions related to acetaminophen usage.

    Objectives: To conduct a systematic review to characterize reported reactions to acetaminophen in adults and children, and perform a meta-analysis to assess the prevalence of acetaminophen hypersensitivity in children with a suspected acetaminophen allergy. Read More

    Generalized bullous fixed drug eruption imitating toxic epidermal necrolysis: a case report and literature review.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Baylor College of Medicine, Department of Dermatology, Houston, Texas.
    Fixed drug eruption (FDE) is defined as sharply demarcated erythematous patches or plaques that occur secondary to systemic exposure to a causative medication. Eruptions are deemed "fixed" because upon repeated exposure they recur at previously affected sites. Generalized bullous fixed drug eruption (GBFDE) is a rare FDE variant occurring in patients with a previous history of FDE. Read More

    Treatments for Severe Cutaneous Adverse Reactions.
    J Immunol Res 2017 27;2017:1503709. Epub 2017 Dec 27.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. Read More

    Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis.
    Drug Saf Case Rep 2018 Jan 2;5(1). Epub 2018 Jan 2.
    Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Street, Capa, Istanbul, Turkey.
    We present a rare case of generalized fixed drug eruption caused by fluconazole. A 45-year-old female patient was referred to our outpatient clinic because of suspicious drug eruptions that occurred 5 months earlier and resolved within a month. The patient had sequela of hyperpigmentation on her arms, legs, back, and abdomen after oral administration of the fourth dose of 150 mg of fluconazole once daily because of vaginal candidiasis. Read More

    Cutaneous Adverse Drug Reactions in a Tertiary Care Teaching Hospital in India: An Intensive Monitoring Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):618-625
    Department of Skin and VD, GMERS Medical College, Gotri, Vadodara, Gujarat, India.
    Background: The epidemiological data based on intensive monitoring studies are limited for the cutaneous adverse drug reactions (CADRs) in terms of incidence. Most of earlier Indian studies focused only on types and causative drugs of CADRs.

    Aim: The aim of this study is to analyze the CADRs with reference to the incidence, its subgroup analysis, causative drugs, and other clinical characteristics in Indian population. Read More

    Skin diseases of the male external genitalia in the Tanlangai Hospital in Brazzaville, Congo.
    Med Sante Trop 2017 Aug;27(3):296-300
    CHU Brazzaville, 13 avenue Auxence-IKonga, Brazzaville, Congo.
    To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. Read More

    Olanzapine-induced Skin Eruptions.
    Indian J Psychol Med 2017 Jul-Aug;39(4):537-538
    Department of Psychiatry, National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
    Adverse cutaneous reactions are known to occur with psychotropic medications, which may lead to poor drug compliance. As compared to other group of psychotropics, there is relatively scarce literature on olanzapine-induced skin eruptions. We present a case of a 39-year-old man diagnosed with first episode mania and alcohol dependence syndrome who was started on tablet olanzapine which leads to fixed drug eruptions. Read More

    Three Cases of Autoimmune Progesterone Dermatitis.
    Ann Dermatol 2017 Aug 21;29(4):479-482. Epub 2017 Jun 21.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. Read More

    Prevalence and Clinical Profile of Drug Eruptions among Antiretroviral Therapy-Exposed HIV Infected People in Yaoundé, Cameroon.
    Dermatol Res Pract 2017 28;2017:6216193. Epub 2017 Jun 28.
    Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
    Background: Prevalence and incidence of drug eruptions vary around the world and are influenced by some key factors including HIV infection.

    Objective: This study aimed to find the peculiarities of drug eruptions in people living with HIV (PLHIV) and on antiretroviral therapy (ART).

    Methods: This was a retrospective cross-sectional study including ART-taking PLHIV, aged 15+ years, followed up between January 2010 and December 2014 at the day-care unit of the Yaoundé Central Hospital, and who presented with drug eruptions after ART initiation. Read More

    Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

    Factitious Dermatitis Due to Thermal Burn With Histologic Features Simulating Fixed Drug Eruption.
    Am J Dermatopathol 2017 Aug;39(8):622-624
    *Department of Dermatology, University of Cincinnati, Cincinnati, OH; †Miraca Life Sciences Research Institute, Irving, TX; and ‡Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.
    Factitious dermatitis (FD) (dermatitis artefacta) is rare and often difficult to diagnose because of conflicting history and nonspecific clinical and histologic findings. It can present with varied clinical features including geometric ulcers, erosions, and less commonly bullae secondary to external trauma from chemicals, electric burns, heat, and suction. Herein, we describe a case of bullous FD due to thermal burn with histologic features demonstrating overlap with fixed drug eruption. Read More

    Dapsone-associated fixed drug eruption.
    Expert Rev Clin Pharmacol 2017 Jul 28;10(7):717-725. Epub 2017 Apr 28.
    b Department of Dermatology , University of California, San Diego , La Jolla , CA , USA.
    Introduction: Dapsone is a sulfone drug used to treat infectious conditions and also numerous dermatologic diseases. Fixed drug eruption is a distinctive adverse cutaneous reaction associated with the initial administration and subsequent delivery of a specific agent. Areas covered: The authors preformed a literature search using the following keywords: dapsone, fixed drug eruption, and adverse cutaneous drug reaction. Read More

    [Epicutaneous patch testing in delayed drug hypersensitivity reactions induced by antiepileptic drugs].
    Therapie 2017 Oct 25;72(5):539-545. Epub 2017 Mar 25.
    Centre régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. Read More

    Lichenoid and interface dermatoses.
    Semin Diagn Pathol 2017 May 22;34(3):237-249. Epub 2017 Mar 22.
    Department of Radiation Oncology, The Ohio State University, Columbus, OH, United States.
    The terms 'lichenoid' and 'interface' dermatitis are often used interchangeably to describe an inflammatory pattern characterized histologically by damage to the basal keratinocytes in the epidermis. The mechanism of cell damage of such cells is now best understood as apoptosis, or programmed cell death. This inflammatory pattern of dermatoses, is also accompanied frequently by a band of lymphocytes and histiocytes in the superficial dermis, that often obscures the dermal-epidermal junction, hence the term 'lichenoid'. Read More

    Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis.
    Curr Allergy Asthma Rep 2017 Apr;17(4):23
    Allergy Unit, Presidio Columbus, Via G. Moscati, 31, 00168, Rome, Italy.
    Non-immediate cutaneous reactions (i.e., occurring at least 1 h after the initial drug administration), particularly maculopapular exanthemas and urticarial eruptions, are common during beta-lactam treatments. Read More

    Generalized bullous fixed drug eruption treated with cyclosporine.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Department of Dermatology, University of Texas Southwestern Medical Center.
    Fixed drug eruptions (FDE) comprise 10 percent of alladverse cutaneous drug reactions and generalizedbullous fixed drug eruptions (GBFDE) are a raresubset of FDEs. We present a patient with severeGBFDE caused by ibuprofen successfully treated withcyclosporine. Further work is needed to determine ifcyclosporine can be an effective therapy for GBFDE. Read More

    Metronidazole and Norfloxacin induced Generalized Fixed Drug Eruptions in an adult male patient - A Case Report.
    Curr Drug Saf 2017 Feb 9. Epub 2017 Feb 9.
    Government Medical College and Sir Takhtsinhji General Hospital,India.
    Introduction: Fluoroquinolones are most widely used for empirical treatment of gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also indulged in cutaneous adverse drug reactions with varying form of severity.

    Case Presentation: A 43 year old male patient developed fixed drug eruptions after administration of tablet norfloxacin and metronidazole for treatment of colicky abdominal pain with diarrhoea. Read More

    [Triggers of exanthematous drug eruptions: Stop intake, treat through or desensitization?]
    Hautarzt 2017 Jan;68(1):29-35
    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
    Drug hypersensitivity reactions affect over 7% of the population and are problematic both for patients and doctors. They frequently occur in the form of exanthematous drug eruptions. The clinical manifestation of delayed hypersensitivity reactions is very variable ranging from localized fixed drug eruptions to life-threatening, severe bullous mucocutaneous eruptions or systemic drug hypersensitivity syndromes. Read More

    Metformin-Induced Generalized Fixed Drug Eruption With Cutaneous Hemophagocytosis.
    Am J Dermatopathol 2017 Jun;39(6):471-475
    Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
    Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Read More

    [A fixed drug eruption caused by paracetamol].
    Ned Tijdschr Geneeskd 2016 ;160(0):D470
    Huisartsenpraktijk Nederweert, Nederweert.
    Background: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1. Read More

    Fixed drug eruption by etoricoxib confirmed by patch test.
    An Bras Dermatol 2016 Sep-Oct;91(5):652-654
    Hospital Universitário de Coimbra - Coimbra, Portugal.
    Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. Read More

    Severe antiretroviral-associated skin reactions in South African patients: a case series and case-control analysis.
    Pharmacoepidemiol Drug Saf 2016 Nov 27;25(11):1313-1319. Epub 2016 Jul 27.
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
    Purpose: Severe skin reactions may complicate combination antiretroviral therapy (cART). Nevirapine is known to be associated with severe skin reactions, but there are conflicting data on risk factors in African patients. We reviewed cases of severe skin reactions admitted to a tertiary hospital in Cape Town, South Africa. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    Generalized Bullous Fixed Drug Eruption due to Bromhexine.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Department of Dermatology and Venereology, Centro Hospitalar de São João EPE, Porto, Portugal.
    We describe a patient with a generalized bullous form of Fixed Drug Eruption (FDE) induced by bromhexine, a commonly used drug for respiratory symptoms. This is a rare association and generalized bullous FDE is also very rare. We emphasize the importance of patch tests in identifying the culprit drug. Read More

    [Mucosal diseases from an allergological perspective].
    Hautarzt 2016 Oct;67(10):780-785
    Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

    [Unintended rechallenge : Generalized bullous fixed drug eruption in two elderly women].
    Hautarzt 2017 Jan;68(1):59-63
    Dokumentationszentrum schwerer Hautreaktionen, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Severe bullous skin reactions like Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and generalized bullous fixed drug eruption (GBFDE) are rare, but occasionally fatal diseases which are mainly induced by drugs. We report about 2 women who both developed severe bullous skin reactions after domestic falls. Despite knowing the causative drug and having an allergy identification, both patients suffered from a secondary event after unintentional re-exposure. Read More

    Histopathological study of six types of adverse cutaneous drug reactions using granulysin expression.
    Int J Dermatol 2016 Nov;55(11):1225-1233
    Department of Dermatology, Strasbourg University Hospital, Strasbourg, France.
    Background: Few studies have been published on the histopathology of cutaneous adverse drug reactions (CADR), and most of these lack information on skin allergological tests. The histopathology of drug reaction with eosinophilia and systemic symptoms (DRESS) is also seldom described. The purpose of our study was to examine six types of well-documented CADR (maculopapular exanthema, DRESS, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis [TEN], and acute generalized exanthematous pustulosis) using histopathology and immunohistochemistry to evaluate the expression of granulysin, a key molecule in TEN. Read More

    A Comparative Analysis Between Antibiotic- and Nonantibiotic-Associated Delayed Cutaneous Adverse Drug Reactions.
    J Allergy Clin Immunol Pract 2016 Nov - Dec;4(6):1187-1193. Epub 2016 Jun 7.
    Department of Infectious Diseases, Alfred Health & Monash University, Melbourne, Victoria, Australia.
    Background: The difference in clinical presentation, causality assessments, and outcomes of patients with delayed antibiotic-associated cutaneous adverse drug reactions (AA-cADR) and nonantibiotic-associated (NA)-cADR is ill defined.

    Objective: We examined the etiology of AA-cADR, with regard to the type of antibiotic exposure, allergy labeling, and patient outcomes, in comparison with NA-cADR.

    Methods: A retrospective observational inpatient cohort study of cADR was performed from January 2004 to August 2014. Read More

    Fixed Drug Eruption Late in the Course of Capecitabine Therapy.
    Conn Med 2016 Apr;80(4):223-5
    A fixed drug eruption (FDE) is a toxic skin effect thought to be caused by delayed cell-mediated hypersensitivity to a pharmaceutical agent. We report herein the first known patient with capecitabine-induced FDE that appeared relatively late in the course of adjuvant therapy for rectal cancer. The temporal association with capecitabine use and prompt disappearance after capecitabine discontinuation make this relationship probable. Read More

    Antibiotic prophylaxis for skin toxicity induced by antiepidermal growth factor receptor agents: a systematic review and meta-analysis.
    Br J Dermatol 2016 Dec 30;175(6):1166-1174. Epub 2016 Sep 30.
    Oncology Unit, Oncology Department, ASST Bergamo Ovest, Piazzale Ospedale 1, 24047, Treviglio (BG), Italy.
    Topical and systemic prophylactic measures, which are administered before the development of epidermal growth factor receptor (EGFR)-related acneiform rash, are appropriate interventions to mitigate the intensity of skin toxicity. We have performed a systematic review and meta-analysis to evaluate whether prophylactic antibiotics may reduce the occurrence and severity of anti-EGFR drug-related skin rashes. A systematic review was performed by searching Medline, Scopus, Embase, CINAHL, LILACS, Web of Science and the Cochrane Library from inception until March 2016 for publications regarding the pre-emptive role of antibiotics for EGFR-induced skin rashes. Read More

    Acemetacin-induced fixed drug eruption.
    Indian J Pharmacol 2016 Mar-Apr;48(2):219-20
    Department of Pathology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
    Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other musculoskeletal disorders. We present a case of acemetacin-induced FDE in a 49-year-old woman. Read More

    [Fixed drug eruption to clarithromycin: The importance of challenge tests in diagnosis].
    Ann Dermatol Venereol 2016 Dec 11;143(12):852-855. Epub 2016 Apr 11.
    Service immunologie clinique et allergologie, centre hospitalier Lyon-Sud, 69495 Pierre-Bénite cedex, France; Inserm U1111-CIRI, 21, avenue T.-Garnier, 69007 Lyon, France; Université Claude-Bernard-Lyon I, 43, boulevard du 11-Novembre-1918, 69100 Villeurbanne, France.
    Background: Determining the substance responsible for recurrent fixed drug eruption (FDE) may be difficult in the case of patients on multiple medication. Allergy testing may prove invaluable in such situations, as we demonstrate herein with an original case.

    Patients And Methods: A 49-year-old man presented a rash on the seventh day of treatment with esomeprazole, clarithromycin and amoxicillin prescribed for gastritis involving Helicobacter pylori. Read More

    Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.
    Am J Case Rep 2016 Apr 8;17:231-4. Epub 2016 Apr 8.
    Levine College of Health Sciences, Wingate University, Wingate, NC, USA.
    Background: A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Read More

    Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor.
    Eur J Cancer 2016 06 1;60:12-25. Epub 2016 Apr 1.
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address:
    Background: Dermatologic adverse events (AEs) are some of the most frequently observed toxicities of immune-checkpoint inhibitor therapy, but they have received little attention. The drugs, pembrolizumab and nivolumab are recently approved inhibitors of the programmed death (PD)-1 receptor that have overlapping AE profiles however, the incidence, relative risk (RR), and clinico-morphological pattern of the associated dermatologic AEs are not known.

    Methods: We conducted a systematic review of the literature, and performed a meta-analysis of dermatologic AEs observed with the use of pembrolizumab and nivolumab in cancer patients. Read More

    Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
    Recent Pat Inflamm Allergy Drug Discov 2016 ;10(1):61-63
    Hospital General Universitario Gregorio Marañón. Allergy Department, 46 th Doctor Esquerdo Avenue, 28007 Madrid, Spain.
    Background: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported.

    Objective: A 38-year-old woman referred that after 2 hours of taking 2 tablets of naproxen for a headache, she developed several edematous and dusky-red macules, one on right forearm and the other two in both thighs and she was diagnosed with FDE probably due to naproxen. Read More

    Azithromycin induced bullous fixed drug eruption.
    Indian J Pharmacol 2016 Jan-Feb;48(1):83-5
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Fixed drug eruption (FDE) is a common type of drug eruption seen in skin clinics. It is characterized by solitary or multiple, round to oval erythematous patches with dusky red centers, some of which may progress to bulla formation. Bullous FDE may be caused by a number of drugs. Read More

    Bullous Fixed Drug Eruption Probably Induced by Paracetamol.
    Indian J Dermatol 2016 Jan-Feb;61(1):121
    Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
    We report a case of a 42-year-old male who presented with second episode of bullous eruptions after ingestion of paracetamol. There were no systemic complaints. The temporal correlation with the drug, history of a similar episode and the quick improvement led us to a diagnosis of bullous fixed drug due to paracetamol. Read More

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