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    924 results match your criteria Fixed Drug Eruptions

    1 OF 19

    Metronidazole and Norfloxacin induced Generalized Fixed Drug Eruptions in an adult male patient - A Case Report.
    Curr Drug Saf 2017 Feb 9. Epub 2017 Feb 9.
    Government Medical College and Sir Takhtsinhji General Hospital,India.
    Introduction: Fluoroquinolones are most widely used for empirical treatment of gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also indulged in cutaneous adverse drug reactions with varying form of severity.

    Case Presentation: A 43 year old male patient developed fixed drug eruptions after administration of tablet norfloxacin and metronidazole for treatment of colicky abdominal pain with diarrhoea. Read More

    [Triggers of exanthematous drug eruptions: Stop intake, treat through or desensitization?]
    Hautarzt 2017 Jan;68(1):29-35
    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
    Drug hypersensitivity reactions affect over 7% of the population and are problematic both for patients and doctors. They frequently occur in the form of exanthematous drug eruptions. The clinical manifestation of delayed hypersensitivity reactions is very variable ranging from localized fixed drug eruptions to life-threatening, severe bullous mucocutaneous eruptions or systemic drug hypersensitivity syndromes. Read More

    Metformin-Induced Generalized Fixed Drug Eruption With Cutaneous Hemophagocytosis.
    Am J Dermatopathol 2016 Dec 19. Epub 2016 Dec 19.
    Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
    Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Read More

    [A fixed drug eruption caused by paracetamol].
    Ned Tijdschr Geneeskd 2016 ;160(0):D470
    Huisartsenpraktijk Nederweert, Nederweert.
    Background: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    [Mucosal diseases from an allergological perspective].
    Hautarzt 2016 Oct;67(10):780-785
    Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

    Fixed Drug Eruption Late in the Course of Capecitabine Therapy.
    Conn Med 2016 Apr;80(4):223-5
    A fixed drug eruption (FDE) is a toxic skin effect thought to be caused by delayed cell-mediated hypersensitivity to a pharmaceutical agent. We report herein the first known patient with capecitabine-induced FDE that appeared relatively late in the course of adjuvant therapy for rectal cancer. The temporal association with capecitabine use and prompt disappearance after capecitabine discontinuation make this relationship probable. Read More

    Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.
    Am J Case Rep 2016 Apr 8;17:231-4. Epub 2016 Apr 8.
    Levine College of Health Sciences, Wingate University, Wingate, NC, USA.
    Background: A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Read More

    Fixed Drug Eruption Due to Selective Hypersensitivity to Naproxen with Tolerance to other Propionic Acid NSAIDs.
    Recent Pat Inflamm Allergy Drug Discov 2016 ;10(1):61-63
    Hospital General Universitario Gregorio Marañón. Allergy Department, 46 th Doctor Esquerdo Avenue, 28007 Madrid, Spain.
    Background: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported.

    Objective: A 38-year-old woman referred that after 2 hours of taking 2 tablets of naproxen for a headache, she developed several edematous and dusky-red macules, one on right forearm and the other two in both thighs and she was diagnosed with FDE probably due to naproxen. Read More

    Azithromycin induced bullous fixed drug eruption.
    Indian J Pharmacol 2016 Jan-Feb;48(1):83-5
    Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.
    Fixed drug eruption (FDE) is a common type of drug eruption seen in skin clinics. It is characterized by solitary or multiple, round to oval erythematous patches with dusky red centers, some of which may progress to bulla formation. Bullous FDE may be caused by a number of drugs. Read More

    Bullous Fixed Drug Eruption Probably Induced by Paracetamol.
    Indian J Dermatol 2016 Jan-Feb;61(1):121
    Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
    We report a case of a 42-year-old male who presented with second episode of bullous eruptions after ingestion of paracetamol. There were no systemic complaints. The temporal correlation with the drug, history of a similar episode and the quick improvement led us to a diagnosis of bullous fixed drug due to paracetamol. Read More

    Fixed Drug Eruption due to Achiote Dye.
    Case Rep Dermatol 2016 Jan-Apr;8(1):14-8. Epub 2016 Jan 28.
    Department of Dermatology, Columbia University, New York, N.Y., USA.
    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. Read More

    Neutrophilic Dermatosis Limited to Lipo-Lymphedematous Skin in a Morbidly Obese Woman on Dasatinib Therapy.
    Am J Dermatopathol 2016 Feb;38(2):e22-6
    Department of Pathology, Albany Medical College, Albany, NY.
    Neutrophilic dermatosis (ND) confined to postmastectomy lymphedema, localized Sweet syndrome, is a newly recognized disease. In this study, the authors describe a 44-year-old obese woman with chronic myelogenous leukemia in molecular remission on dasatinib therapy, who presented with a painful urticarial eruption limited to lipo-lymphedematous skin and accompanied by malaise, episodic fever, diarrhea, neutrophilia, and leukocytosis. Initially transient and migratory, the rash became fixed, papular, and vesicular and showed minimal response to corticosteroids. Read More

    Multifocal Bullous Fixed Drug Erruption Due To Phenytoin: A Lesson Learned!
    J Clin Diagn Res 2015 Dec 1;9(12):OD04-5. Epub 2015 Dec 1.
    Director Professor and Head, Department of Medicine, Maulana Azad Medical College , New Delhi, India .
    Antiepileptic drugs (AED) are a common culprit of cutaneous eruptions in clinical practice. Phenytoin, lamotrigine and carbamazepine are the commonest offenders. Maculopapular eruptions are the most frequently reported events. Read More

    Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005-2014).
    Dermatol Res Pract 2015 10;2015:236703. Epub 2015 Dec 10.
    Kermanshah University of Medical Sciences (KUMS), Kermanshah 6714415333, Iran.
    Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. Read More

    Nevirapine: Most Common Cause of Cutaneous Adverse Drug Reactions in an Outpatient Department of a Tertiary Care Hospital.
    J Clin Diagn Res 2015 Nov 1;9(11):FC17-20. Epub 2015 Nov 1.
    Associate Professor, Department of Pharmacology, Government Medical College , Miraj, India .
    Introduction: Skin is the most commonly involved organ in adverse drug reactions. Most of the cutaneous adverse drug reactions (CADRs) being of mild to moderate severity are likely to be diagnosed and treated in an outpatient setting. Consequently, knowledge regarding morphological pattern, severity and drugs implicated in causation of these CADRs has important implications for healthcare personnel. Read More

    Adverse cutaneous drug eruptions: current understanding.
    Semin Immunopathol 2016 Jan 9;38(1):75-86. Epub 2015 Nov 9.
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.
    Adverse cutaneous drug reactions are recognized as being major health problems worldwide causing considerable costs for health care systems. Most adverse cutaneous drug reactions follow a benign course; however, up to 2% of all adverse cutaneous drug eruptions are severe and life-threatening. These include acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Read More

    Condiments Costing High. . . ! A Case Report of Erythema Multiforme.
    J Clin Diagn Res 2015 Jul 1;9(7):ZD22-4. Epub 2015 Jul 1.
    Associate Professor, Department of Oral Medicine and Radiology, SVS Institute of Dental Sciences , Appanapally, Mahabubnagar, Telangana, India .
    Adverse drug associated mucocutaneous reactions having a preponderance to occur above 1% include urticaria, angioedema, photosensitivity, fixed drug eruptions and Erythema Multiforme (EM). EM is an acute inflammatory disease of the skin and mucous membranes that causes a variety of skin lesions-hence named 'multiforme'. The aetiological spectrum of EM is wide and is attributed to infectious agents, drugs and food additives. Read More

    Tranexamic Acid-Induced Fixed Drug Eruption.
    Indian J Dermatol 2015 Jul-Aug;60(4):421
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
    A 33-year-old male showed multiple pigmented patches on his trunk and extremities after he took tranexamic acid for common cold. He stated that similar eruptions appeared when he was treated with tranexamic acid for influenza 10 months before. Patch test showed positive results at 48 h and 72 h by 1% and 10% tranexamic acid at the lesional skin only. Read More

    J Biol Regul Homeost Agents 2015 Apr-Jun;29(2):379-88
    Tuberculosis Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
    This paper aimed to explore the therapeutic effect and safety of Fixed-dose Combinations (FDCs) on tuberculosis. A computer search was carried out to review the literature related to clinical randomized controlled trials (RCTs) and clinical controlled trails (CCTs) on the curative effect and safety of treating pulmonary tuberculosis with FDCs. The results demonstrated that, in the 22 studies examined, comparison of sputum negative conservation rate of treating smear-positive pulmonary tuberculosis with FDCs and single drug, the relative risk (RR) value and 95% confidence interval (CI) were 1. Read More

    Chlorhexidine Anaphylaxis Masquerading as Septic Shock.
    Int Arch Allergy Immunol 2015 19;167(1):16-20. Epub 2015 Jun 19.
    University Orthopaedics, Hand and Reconstructive Microsurgery Cluster, National University Hospital, Singapore, Singapore.
    Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Its usage has increased in recent years with intensive campaigns and infection control guidelines to combat hospital-acquired infections. As a result, patients and health-care workers (HCW) are exposed to increasing chlorhexidine usage. Read More

    Severe drug-induced skin reactions: clinical features, diagnosis, etiology, and therapy.
    J Dtsch Dermatol Ges 2015 Jul;13(7):625-45
    Drugs can induce severe skin reactions that differ in clinical presentation, prognosis, and therapy. The spectrum of these reactions not only includes bullous reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and generalized bullous fixed drug eruption (GBFDE) but also acute generalized exanthematous pustulosis (AGEP) and drug reaction with eosinophilia and systemic symptoms (DRESS). If AGEP or DRESS is suspected, the diagnosis should be confirmed by thorough clinical examination, a skin biopsy, and specific laboratory tests. Read More

    Fixed drug eruptions with intraoral presentation.
    Indian J Dent 2015 Apr-Jun;6(2):103-6
    Department of Oral Pathology, Dental College, Azamgarh, Uttar Pradesh, India.
    Fixed-drug eruption (FDE) is an unusual and rare adverse drug reaction. This type of reaction is actually a delayed type of hypersensitivity reaction that occurs as lesions recurring at the same skin site due to repeated intake of an offending drug. Here is a case report of a 58-year-old male patient who developed intraoral FDEs after ingestion of the first dose of ornidazole. Read More

    Olanzapine-Induced Reversible Pellagroid Skin Lesion.
    Curr Drug Saf 2015 ;10(3):251-3
    Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, 576104, India.
    Adverse cutaneous reactions are frequently reported to occur with the use of psychotropic medications, which may lead to poor drug compliance. As compared to other groups of psychotropic medication, antipsychotics, both typical and atypical, are less likely to cause adverse cutaneous reactions. The most frequent cutaneous adverse reactions associated with antipsychotics include fixed drug eruptions, exanthematous eruptions, photosensitivity reactions and altered skin pigmentation. Read More

    Pyridoxine induced rosacea-like dermatitis.
    Acta Clin Croat 2015 Mar;54(1):99-102
    Rosacea is a common chronic inflammatory cutaneous disease of unknown etiology, characterized by remissions and exacerbations, presenting with centrofacial erythema and telangiectasias. It affects mainly adults around the age of 30 years and classically predominates in females. The pathophysiology of rosacea has not yet been fully understood. Read More

    Incidence and risk of hand-foot skin reaction with cabozantinib, a novel multikinase inhibitor: a meta-analysis.
    Clin Exp Dermatol 2016 Jan 25;41(1):8-15. Epub 2015 May 25.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Background: Cabozantinib is approved in the treatment of progressive, metastatic medullary thyroid cancer (MTC). It is a small molecule inhibitor, which targets multiple receptors, including vascular endothelial growth factor receptor, tyrosine kinase with Ig and epidermal growth factor homology domains-2 and the proto-oncogenes MET (mesenchymal-epithelial transition factor) and RET (rearranged during transfection). The drug is currently in phase I/II/III clinical trials for a number of other solid tumours and haematological malignancies. Read More

    Specificity of dermal mucin in the diagnosis of lupus erythematosus: comparison with other dermatitides and normal skin.
    J Cutan Pathol 2015 Oct 21;42(10):722-9. Epub 2015 May 21.
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
    Increased dermal mucin is a feature of lupus erythematosus (LE); however, its amount and distribution have not been well characterized. The differentiation of LE from other forms of dermatitis can be challenging when other features of LE are subtle or equivocal. One hundred and thirty-five skin specimens showing LE, graft vs. Read More

    Fixed drug eruptions with modafinil.
    Indian J Pharmacol 2015 Mar-Apr;47(2):224-6
    Department of Psychiatry, R. G. Kar Medical College, Kolkata, West Bengal, India.
    Modafinil is a psychostimulant drug, which has been approved by the US Food and Drug Administration for the treatment of narcolepsy associated excessive daytime sleepiness, sleep disorder related to shift work, and obstructive sleep apnea syndrome. However, presently it is being used as a lifestyle medicine; in India, it has been misused as an "over the counter" drug. Modafinil is known to have several cutaneous side effects. Read More

    Adverse cutaneous drug reactions--a clinico-demographic study in a tertiary care teaching hospital of the Kashmir Valley, India.
    Arch Iran Med 2015 Apr;18(4):228-33
    Department of Dermatology, Sher-I-Kashmir Institute of Medical Sciences-Medical College Hospital, Bemina, Srinagar, India.
    Background: Adverse cutaneous drug reactions (ACDRs) are caused by a wide variety of agents. The aim was to study the incidence and clinico-demographic profile of ACDRs to identify any potential risk factors and compare the results with other studies.

    Methods: A cross-sectional observational study was conducted over a period of one year from October 2012 to October 2013 in the outpatient department (OPD) of a tertiary care teaching hospital of the Kashmir valley in India and various ACDRs were recorded. Read More

    Metronomic chemotherapy in the neoadjuvant setting: results of two parallel feasibility trials (TraQme and TAME) in patients with HER2+ and HER2- locally advanced breast cancer.
    Braz J Med Biol Res 2015 May 6;48(5):479-85. Epub 2015 Mar 6.
    Divisão de Oncologia Médica, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
    Neoadjuvant chemotherapy has practical and theoretical advantages over adjuvant chemotherapy strategy in breast cancer (BC) management. Moreover, metronomic delivery has a more favorable toxicity profile. The present study examined the feasibility of neoadjuvant metronomic chemotherapy in two cohorts [HER2+ (TraQme) and HER2- (TAME)] of locally advanced BC. Read More

    Drug-induced skin reactions: a 2-year study.
    Clin Cosmet Investig Dermatol 2015 9;8:53-6. Epub 2015 Feb 9.
    Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran ; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
    Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity.

    Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies were also performed. Read More

    [Fixed drug eruption after taking ethambutol].
    Rev Mal Respir 2015 Jan 29;32(1):48-51. Epub 2014 Apr 29.
    Service de pneumophtisiologie, CHU de Treichville, BP V 3, Abidjan, Côte d'Ivoire.
    Introduction: Fixed drug eruption (FDE) is a specific skin reaction and the only exclusively medicinal dermatosis. Among the drugs usually responsible are the antituberculous antibiotics including rifampicin and, less often, isoniazid and pyrazinamide. FDE after taking ethambutol is rarely described. Read More

    [Drug patch tests in the investigation of a fixed drug eruption subsequent to 2 courses of cyclophosphamide in combination with mesna].
    Ann Dermatol Venereol 2015 Jan 11;142(1):37-40. Epub 2014 Aug 11.
    Service de dermatologie, hôpital d'instruction des armées Sainte-Anne, BP 20545, 83800 Toulon cedex 9, France.
    Background: When fixed drug eruption occurs following use of cyclophosphamide and mesna, it is difficult to establish which drug is responsible. We report a new case of patch tests that resulted in withdrawal of mesna and enabled continued treatment with cyclophophamide.

    Patients And Methods: A 57-year-old female patient with multiple sclerosis presented increasingly severe cutaneous lesions after successive courses of cyclophosphamide. Read More

    Cutaneous adverse drug reactions in Indian population: A systematic review.
    Indian Dermatol Online J 2014 Dec;5(Suppl 2):S76-86
    Department of Pharmacology, GMERS Medical College, Gotri, Vadodara, Gujarat, India.
    Background: Epidemiological data is limited for cutaneous adverse drug reactions (CADRs) in India. Most of the Indian studies have small sample size and are of limited duration.

    Aims: The aim of this study is to analyze CADRs with reference to the causative drugs and their clinical characteristics in Indian population. Read More

    [Allergic diseases in the genital area].
    Hautarzt 2015 Jan;66(1):45-52
    Universitätsklinikum Heidelberg, Thibautstraße 3, 69115, Heidelberg, Deutschland,
    Background: The genital area has a high exposure to various allergens that are not always obvious. Out of shame patients may not complain about symptoms in this area. Moreover, diagnosis and therapy are often not primarily conducted by a dermatologist and allergologist. Read More

    An update of fixed drug eruptions in Singapore.
    J Eur Acad Dermatol Venereol 2015 Aug 10;29(8):1539-44. Epub 2014 Dec 10.
    National Skin Centre, Singapore.
    Background: Fixed drug eruptions (FDE) are most commonly caused by antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). The list of causative drugs changes with time and prescribing patterns but there has been no recent data on FDE seen in an outpatient setting in Singapore.

    Objective: We aimed to evaluate the epidemiology, clinical features and causative drugs in patients with FDE in Singapore. Read More

    [Cutaneous adverse drug reactions].
    Rev Med Interne 2015 Apr 4;36(4):256-70. Epub 2014 Nov 4.
    Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; Centre référence des maladies bulleuses immunologiques et toxiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.
    Cutaneous adverse drug reactions (CADR) represent a heterogeneous field including various clinical patterns without specific features suggesting drug causality. Exanthematous eruptions, urticaria and vasculitis are the most common forms of CADR. Fixed eruption is uncommon in western countries. Read More

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