3,772 results match your criteria Fitoterapia [Journal]


Four limonoids from Bacillus subtilis-fermented neem seeds and their cytotoxic activity.

Fitoterapia 2019 Apr 15. Epub 2019 Apr 15.

College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address:

Four new limonoids, 7,12-dihydroxyvilasinone (1), vilasindione (2), 4-dehydroxynimbandiol (3) and azadiramide B (4), were isolated from extracts of Bacillus subtilis-fermented neem seeds. Their planar structures and relative configurations were elucidated by spectroscopic methods including UV, IR, MS and NMR, and the absolute stereochemistry was determined by comparing their experimental and calculated CD spectra. 4 is a rare salannin-class limonoid alkaloid. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.004DOI Listing

New anti-HBV norbisabolane sesquiterpenes from Phyllantus acidus.

Fitoterapia 2019 Apr 15. Epub 2019 Apr 15.

Center for Pharmaceutical Sciences, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming 650500, People's Republic of China. Electronic address:

The norbisabolane-type sesquiterpenoids bearing a spiroketal functionality have been found in Phyllanthus spp. and showed anti-HBV activities. As part of an ongoing effort to search for promising anti-HBV sesquiterpenes from Phyllanthus plants, we report four new norbisabolane-type sesquiterpenoids, phyacidusin A (1), phyacidusin B (2), phllanthacidoid A1 (3) and phllanthacidoid N1 (4), from stem of P. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193054
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http://dx.doi.org/10.1016/j.fitote.2019.04.006DOI Listing
April 2019
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Transcriptome analyses of Paris polyphylla var. chinensis, Ypsilandra thibetica, and Polygonatum kingianum characterize their steroidal saponin biosynthesis pathway.

Fitoterapia 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; Yunnan Key Laboratory for Integrative Conservation of Plant Species with Extremely Small Population, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address:

Steroidal saponins, one of the most diverse groups of plant-derived natural products, elicit biological and pharmacological activities; however, the genes involved in their biosynthesis and the corresponding biosynthetic pathway in monocotyledon plants remain unclear. This study aimed to identify genes involved in the biosynthesis of steroidal saponins by performing a comparative analysis among transcriptomes of Paris polyphylla var. chinensis (PPC), Ypsilandra thibetica (YT), and Polygonatum kingianum (PK). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.008DOI Listing

Four new guaiane sesquiterpenoids from agarwood of Aquilaria filaria.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address:

Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.007DOI Listing

Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca-ATPase.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

State Key Laboratory of Natural Medicines and Department of Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

Schefflera kwangsiensis Merr. ex H.L. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.005DOI Listing

Further terpenoids from Euphorbia tirucalli.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193044
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http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing
April 2019
3 Reads

New glucosyloxybenzyl 2R-benzylmalate derivatives from the undergrounds parts of Arundina graminifolia (Orchidaceae).

Fitoterapia 2019 Apr 4;135:33-43. Epub 2019 Apr 4.

Strasbourg University, Faculty of Pharmacy, UMR 7200, 67400 Illkirch-Graffenstaden, France.

Phytochemical investigation of the underground part of the blossoming tropical orchid Arundina graminifolia led to the isolation of six new glucosyloxybenzyl 2R-benzylmalate derivatives named arundinosides L-Q (1-6) together with 5 known compounds arundinosides D-F, J and K (7-11). The structures of the isolated compounds were determined by extensive spectroscopic data analysis. The anti-α-glucosidase and antioxidant activities of the isolated compounds were determined. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.030DOI Listing

Four new sesquiterpenoids with anti-inflammatory activity from the stems of Jasminum officinale.

Fitoterapia 2019 Apr 1;135:22-26. Epub 2019 Apr 1.

The Ministry of Education Key Laboratory for Standardization of Chinese Medicines, The State Administration of Traditional Chinese Medicine Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Four new sesquiterpenoids,including three nor-cinalbicane type sesquiterpenoids, named Jasminol A, G, H (1-3) and one eremophilene-type sesquiterpenoid, named Jasminol B (4) together with nine known compounds (5-13) were isolated from the stems of Jasminum officinale L. The structures of new compound were elucidated on the base of IR, HR-ESI-MS, 1D NMR, 2D NMR and DEPT analysis, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. In addition, the anti-inflammatory activity of isolated compounds was evaluated using lipopolysaccharide (LPS)-induced murine macrophage RAW264. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193022
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http://dx.doi.org/10.1016/j.fitote.2019.03.029DOI Listing
April 2019
2 Reads

Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301.

Fitoterapia 2019 Apr 1;135:27-32. Epub 2019 Apr 1.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. Electronic address:

Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.031DOI Listing

A rotameric tryptamide alkaloid from the roots of Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae).

Fitoterapia 2019 Apr 1;135:9-14. Epub 2019 Apr 1.

Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. Electronic address:

A rotameric tryptamide alkaloid (1a-1b) was isolated from the methanolic extract of the roots of Vepris lecomteana together with the known compounds anhydroevoxine (2), lecomtequinoline C (3), evoxine (4), N-methylflindersine (5), evoxanthine (6), hesperidin, lupeol, β-sitosterol and stigmasterol. The previously not reported 7-(3-anilino-2-hydroxyprenyloxy)-8-methoxydictamine (2a) was obtained by opening the epoxide of anhydroevoxine (2). The structures of above compounds were determined by comprehensive spectroscopic analyses of 1D and 2D NMR, EI-/ESI-MS, X-ray crystallography and comparison with the reported data. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.028DOI Listing
April 2019
3 Reads

New lignans, sesquiterpenes and other constituents from twigs and leaves of Rhododendron micranthum.

Fitoterapia 2019 Mar 25;135:15-21. Epub 2019 Mar 25.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

Rhododendron micranthum is used traditionally as a remedy for the treatment of chronic bronchitis in China. To clarify the chemical basis and provide a reference for the rational use of this medicinal plant, a phytochemical study was carried out on the twigs and leaves of R. micranthum, which afforded eight new compounds (1-8) and eight known compounds (9-16). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.025DOI Listing
March 2019
1 Read
2.216 Impact Factor

Lycocasuarines I-Q, new Lycopodium alkaloids isolated from Lycopodiastrum casuarinoides.

Fitoterapia 2019 Mar 25;134:474-480. Epub 2019 Mar 25.

State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Lycocasuarines I-Q (1-9), nine new lycodine-type Lycopodium alkaloids were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193041
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http://dx.doi.org/10.1016/j.fitote.2019.03.027DOI Listing
March 2019
8 Reads

Anti-inflammatory constituents from Cortex Dictamni.

Fitoterapia 2019 Mar 25;134:465-473. Epub 2019 Mar 25.

Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Electronic address:

Eight new compounds named as dictamalkosides A (1), B (2), C (3), dictamphenosides A (4), B (5), C (6), D (7) and E (8), as well as 23 known ones were obtained from the 70% EtOH extract of Cortex Dictamni. Their structures were ascertained based on the spectroscopic evidences. Among the known compounds, 14, 17-23, 25-28, and 31 were isolated from Dictamnus genus for the first time; 16 and 24 were firstly isolated from this plant. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.026DOI Listing
March 2019
1 Read
2.216 Impact Factor

Poststerone increases muscle fibre size partly similar to its metabolically parent compound, 20-hydroxyecdysone.

Fitoterapia 2019 Mar 25;134:459-464. Epub 2019 Mar 25.

Institute of Biochemistry of Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary. Electronic address:

In mice, poststerone is a major in vivo metabolite of the worldwide popular anabolic food supplement 20-hydroxyecdysone (20E). Here we present the first study on this ecdysteroid in view of the in vivo anabolic effect of its parent compound, 20E in mammals. We have monitored muscle fibre type cross sectional areas (CSA) of developing rats after treatment with poststerone as we did in a previous study with 20E. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.017DOI Listing

Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum.

Fitoterapia 2019 Mar 23;135:1-4. Epub 2019 Mar 23.

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address:

Two novel 8,15-seco C-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.021DOI Listing
March 2019
1 Read
2.216 Impact Factor

Suppressive effects of collismycin C on polyphosphate-mediated vascular inflammatory responses.

Fitoterapia 2019 Mar 23;134:447-453. Epub 2019 Mar 23.

College of Pharmacy, Cell and Matrix Research Institute, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University (KNU), Daegu 41566, Republic of Korea. Electronic address:

Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. 2,2'-bipyridine containing natural products are generally accepted to have antimicrobial, cytotoxic and anti-inflammatory properties. This study was undertaken to investigate whether a 2,2'-bipyridine containing natural product, collismycins C, can modulate PolyP-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.022DOI Listing

Phenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica.

Fitoterapia 2019 Mar 23;134:485-492. Epub 2019 Mar 23.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address:

Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyses (1D-, 2D-NMR, MS, CD, IR, UV) and chemical methods. Their anti-inflammatory potentials were evaluated by measuring their effects on PGE production of LPS-stimulated RAW264. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.023DOI Listing

Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula.

Fitoterapia 2019 Mar 23;135:5-8. Epub 2019 Mar 23.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Tumour Targeted Therapy and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. Electronic address:

Two new spiroketal derivatives with an unprecedented amino group, 2'-aminodechloromaldoxin (1) and 2'-aminodechlorogeodoxin (2), along with one known analogue dechloromaldoxin (3), were isolated from the plant endophytic fungus Pestalotiopsis flavidula. Their structures were elucidated on the basis of extensive spectroscopic analysis. The purification was cytotoxicity-guided which indicated the extract, fractions and compounds were evaluated in vitro for anti-proliferative activity against a panel of human cancer cell lines. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.020DOI Listing
March 2019
1 Read

Stelleraguaianone B and C, two new sesquiterpenoids from Stellera chamaejasme L.

Fitoterapia 2019 Mar 23;134:443-446. Epub 2019 Mar 23.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address:

Two new sesquiterpenoids were isolated from Stellera chamaejasme L., known as the traditional Chinese herb 'Rui Xiang Lang Du'. The compounds were elucidated as stelleraguaianone B (1) and C (2) by comprehensive spectroscopic analysis, including 1D and 2D NMR as well as HRESIMS, and by comparing their NMR data with known compounds. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.024DOI Listing

Two new cembrane-type diterpenoids from the xisha soft coral Lemnalia flava.

Fitoterapia 2019 Mar 23;134:481-484. Epub 2019 Mar 23.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Further chemical investigation of the South China Sea soft coral Lemnalia flava resulted in the isolation and characterization of two new cembranoids, namely, xishaflavalins G and H (1 and 2), along with three known related compounds (3-5). The structures of the new compounds were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. The discovery of cembrane-type diterpenes from soft coral of the genus Lemnalia was reported for the first time. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.018DOI Listing

Steroidal saponins from the aerial parts of Cordyline fruticosa L. var. strawberries.

Fitoterapia 2019 Mar 23;134:454-458. Epub 2019 Mar 23.

School of Science and Technology, Chemistry Division, University of Camerino, Via S. Agostino 1, I-62032 Camerino, Italy. Electronic address:

A new sulfated steroidal derivative (fruticogenin A: 1-sulfo-australigenin-3-sodium sulphate, 1) and three new steroidal saponins named fruticoside K (3-sulfo-spirostan-25(27)-ene-1β,3β-diol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 2), fruticoside L (3-sulfo-spirostan-25(27)-ene-1β,3β,6α-triol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 3) and fruticoside M (spirostan-25(27)-ene-1β,3α-diol-1-O-[α-L-rhamnopyranosyl-(1 → 2)-α-L-rhamnopyranoside], 4) were isolated from the aerial parts of Cordyline fruticosa L. var. strawberries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193036
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http://dx.doi.org/10.1016/j.fitote.2019.03.019DOI Listing
March 2019
4 Reads

Zizhines G-O, AchE inhibitory meroterpenoids from Ganoderma sinensis.

Fitoterapia 2019 Mar 20;134:411-416. Epub 2019 Mar 20.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China. Electronic address:

Zizhines G-O (1-9), nine new meroterpenoids, and seven known analogs (10-16) were isolated from the dried fruiting bodies of Ganoderma sinensis. Their structures were identified by using spectroscopic data and CD curve comparison. The inhibitory activities of the selected new meroterpenoids toward AchE were assessed in vitro. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.016DOI Listing

Adulteration of commercial grape seed extracts and other proanthocyanidins (PACs)-rich herbal extracts: Multi-compound HPLC profile patterns provide key to detection.

Fitoterapia 2019 Mar 18;134:389-403. Epub 2019 Mar 18.

Network Nutrition, IMCD, 9/7 Meridian Place, Bella Vista, NSW 2153, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2019.03.014DOI Listing
March 2019
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Semi-synthesis and structural elucidation of brevicanines A-D, four new C-diterpenoid alkaloids with rotameric phenomenon from Aconitum brevicalcaratum.

Fitoterapia 2019 Mar 18;134:404-410. Epub 2019 Mar 18.

Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address:

Four new C-diterpenoid alkaloids brevicanines A-D (1-4) with rotameric phenomenon were isolated from Aconitum brevicalcaratum. They all possessed an unusual axial chiral phenyl-quinazoline side chain and their structures were elucidated by extensive spectroscopic analysis and chemical methods. Meanwhile, brevicanines A and B were semi-synthesized from their parent compound scaconine to further confirm their structures. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.012DOI Listing
March 2019
2 Reads

Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells.

Fitoterapia 2019 Mar 18;134:493-500. Epub 2019 Mar 18.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Hypoxia-inducible factor-1 is a target for the management of cancer. Here, the anti-proliferation properties of corosolic acid (CA) against A549 human lung epithelial cancer cells in CoCl-induced hypoxia is reported. CA was isolated from the roots of Salvia syriaca based on a bioassay-guided isolation platform and identified by 1D and 2D NMR experiments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X193021
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http://dx.doi.org/10.1016/j.fitote.2019.03.013DOI Listing
March 2019
2 Reads

Bioactive oxaphenalenone dimers from the fungus Talaromyces macrosporus KKU-1NK8.

Fitoterapia 2019 Mar 18;134:429-434. Epub 2019 Mar 18.

Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address:

Six new polyketide-derived oxaphenalenone dimers, talaromycesone C (1) and macrosporusones A-E (2-6), together with eight known analogs, were isolated from the mycelium of the fungus Talaromyces macrosporus KKU-1NK8. Their structures were established based on their spectroscopic data and MS. The absolute configurations of new compounds 1-6 were determined by ECD analyses. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.015DOI Listing
March 2019
2 Reads

New coumarins and monoterpene galloylglycoside from the stem bark of Sapium baccatum.

Fitoterapia 2019 Mar 18;134:435-442. Epub 2019 Mar 18.

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.

Sapium baccatum has been traditionally used as therapeutic remedies. To support its medicinal benefits, our current phytochemical investigation attempted to further discover novel bioactive compounds from S. baccatum. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.011DOI Listing
March 2019
2 Reads

Commipholactam A, a cytotoxic sesquiterpenoidal lactam from Resina Commiphora.

Fitoterapia 2019 Mar 16;134:382-388. Epub 2019 Mar 16.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China. Electronic address:

Diverse terpenoids including a novel sesquiterpenoidal lactam, commipholactam A (1), and a structurally related new cadinane sesquiterpenoid, commiphorane H (2), a new eudesmane sesquiterpenoid, commiphorane I (4), a new guaiane sesquiterpenoid, commiphorane J (5), and two new nor-abietane diterpenoids, commiphoranes K1 and K2 (6 and 7) along with two known terpenoids (3 and 8), were isolated from Resina Commiphora. Their structures with absolute configurations were characterized by spectroscopic methods and calculated electronic circular dichroism (ECD). Notably, commipholactam A represents the first example of cadinane sesquiterpene alkaloids isolated from Resina Commiphora. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.008DOI Listing

An anti-inflammatory C-stiryl iridoid from Camptosorus sibiricus Rupr.

Fitoterapia 2019 Mar 14;134:378-381. Epub 2019 Mar 14.

Shandong Academy of Pharmaceutical Sciences, Jinan 250101, Shandong, PR China. Electronic address:

A new iridoid glycoside, named camptoside (1), together with three known compounds as dehydrodiconiferyl alcohol-9'-O-β-d-glucopyranoside (2), aesculetin (3) and vajicoside (4), have been isolated from Camptosorus sibiricus Rupr. (Aspleniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D- and 2D-NMR data, and by comparison of their spectroscopic and physical data with those reported in the literature. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.009DOI Listing

Trichobisabolins A-H, eight new bisabolane derivatives from the marine-alga-epiphytic fungus Trichoderma asperellum Y6-2.

Fitoterapia 2019 Mar 14;134:372-377. Epub 2019 Mar 14.

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. Electronic address:

Eight new bisabolane derivatives, trichobisabolins A-H, along with two known ones, (3R,6R,7R)-1,10-bisaboladien-3-ol (9) and (3R,6R,7S)-1,10-bisaboladien-3,6-diol (10) were isolated from the culture of Trichoderma asperellum Y6-2, obtained from the surface of the marine red alga Chondrus ocellatus. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1-8 were assayed for inhibiting the growth of some marine-derived organisms, including four marine phytoplankton species, one marine zooplankton species, and five pathogenic bacteria. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.010DOI Listing

Corrigendum to 'Dimeric 2-(2-phenylethyl)chromones from the agarwood of Aquilaria crassna in Laos'[Fitoterapia 133 (2019) 12-16].

Fitoterapia 2019 Mar 12. Epub 2019 Mar 12.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; Hainan Engineering Research Center of Agarwood, Haikou 571101, China. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2019.03.001DOI Listing
March 2019
5 Reads
2.216 Impact Factor

Anti-tumor effects and 3D-quantitative structure-activity relationship analysis of bufadienolides from toad venom.

Fitoterapia 2019 Mar 12;134:362-371. Epub 2019 Mar 12.

Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China. Electronic address:

Toad venom (venenum bufonis, also called Chan'su) has been widely used for centuries in China to treat different diseases, especially for cancer. Bufadienolides are mainly responsible for the anti-cancer effects of toad venom. However, systematic chemical composition and cytotoxicity as well as key pharmacophores of these bufadienolides from toad venom have not yet been defined clearly. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.006DOI Listing
March 2019
1 Read

Triterpenoids from Euphorbia pulcherrima with inhibitory effects on osteoclastogenesis.

Fitoterapia 2019 Mar 8;134:355-361. Epub 2019 Mar 8.

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, People's Republic of China. Electronic address:

Three new compounds (1-3), euphorimaoid A (1), euphorimaoid B (2), 1α-hydroxy-3β-acetoxy-olean-9,12-diene (3), two firstly isolated natural products 3β-acetyloxy-olean-13(18)-en-12-one (4) and 18,19-epoxyolean-3β-ol acetate (5), together with 13 known compounds (6-18) have been identified from the aerial parts of Euphorbia pulcherrima Willd. Structures of compounds 1-5 were elucidated by comprehensive spectroscopic analysis. The absolute configuration of euphorimaoid A (1) was established using single crystal X-ray diffraction analysis. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.028DOI Listing

Isolation of yeast Ca signal transduction inhibitors from the Early Cretaceous Burmese amber.

Fitoterapia 2019 Mar 8;134:422-428. Epub 2019 Mar 8.

Graduate School of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan. Electronic address:

Two kinds of biologically active compounds were isolated from the MeOH extract of the Early Cretaceous Burmese amber [99 million years ago (Ma)], which is older than the K-Pg boundary (65 Ma). These compounds had inhibitory activity against the hypersensitive mutant yeast strain (zds1∆ erg3∆ pdr1∆ pdr3∆) with respect to Ca signal transduction. They were identified as 16,17-bisnordehydroabietic acid (1) and 16,17-bisnorcallitrisic acid (2), respectively, on the basis of spectral analyses including HREIMS, 1D, and 2D NMR. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.018DOI Listing

Benzofurans from Eupatorium chinense enhance insulin-stimulated glucose uptake in C2C12 myotubes and suppress inflammatory response in RAW264.7 macrophages.

Fitoterapia 2019 Mar 8;134:346-354. Epub 2019 Mar 8.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, People's Republic of China.; Hangzhou Institute of Innovative Medicine, Zhejiang University, 291 Fucheng Road, Hangzhou 310018, People's Republic of China.. Electronic address:

Fourteen acetylbenzofuran derivatives, including three undescribed carbon skeletons with a newly formed hexane or benzene ring on the other side of the benzofuran ring, (±)-eupatonin A (1), (±)-eupatonin B (2), and eupatonin C (3), two new benzofurans (-)-12β-hydroxygynunone (4) and (+)-12-hydroxyl-13-noreuparin (5), as well as 9 known ones (6-14), were isolated from 95% ethanol extract of the roots of Eupatorium chinense. Their structures were determined by spectroscopic methods and quantum chemical DFT and TDDFT calculations of the NMR chemical shifts and ECD spectra, which helped in the determination of the relative configurations of 1 and 2 and the absolute configurations of 4 and 5, respectively. 1 and 2 were further identified to be racemic mixtures by chiral HPLC analysis. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.007DOI Listing

Synthesis, biological function and evaluation of Shikonin in cancer therapy.

Fitoterapia 2019 Mar 8;134:329-339. Epub 2019 Mar 8.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address:

Shikonin is a natural compound isolated from herbs and traditional medicines that have been used in a number of countries to treat various illnesses including inflammation, virus infection and cancer for centuries. Recent studies have shed light on the molecular mechanisms underlying these biological activities of Shikonin. Here we review the latest advances in our understanding of this compound class in the anti-cancer regimen. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.005DOI Listing

Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets.

Fitoterapia 2019 Mar 3;134:270-289. Epub 2019 Mar 3.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Diabetes mellitus (DM), a chronic metabolic disease, severely affects patients' life and intensively increases risks of developing other diseases. It is estimated that 0.4 billion individuals worldwide are subjected to diabetes, especially type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.033DOI Listing

An unprecedented chlorine-containing piperamide from Piper pseudoarboreum as potential leishmanicidal agent.

Fitoterapia 2019 Mar 3;134:340-345. Epub 2019 Mar 3.

Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain. Electronic address:

A phytochemical investigation of the ethanolic extract of leaves from Piper pseudoarboreum led to the isolation of 3-chlorosintenpyridone 1, an unprecedented chlorinated piperamide, together with the known compounds 2-12. Their structures were established based on 1D and 2D (COSY, ROESY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The proposed biosynthetic pathway of compound 1 is discussed. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.004DOI Listing
March 2019
2 Reads

Five novel diarylheptanoids from green walnut husks (Juglans regia L.).

Fitoterapia 2019 Mar 3;134:221-225. Epub 2019 Mar 3.

Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Baojian Road 157, Nangang District, Harbin 150081, PR China.

A ethanol extract of green walnut husks (Juglans regia L.) was isolated by various chromatographic techniques yielding 5 previously unknown diarylheptanoids, namely Juglanin F (1), Juglanin G (2), Juglanin H (3), Juglanin I (4) and Juglanin J (5), respectively, together with 12 known diarylheptanoids. The structures of these 17 compounds were elucidation on the basis of spectroscopic analysis. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.002DOI Listing

The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine.

Fitoterapia 2019 Mar 2;134:210-220. Epub 2019 Mar 2.

School of Life Sciences, Southwest University, Chongqing 400715, China. Electronic address:

Hyperglycemia is a common endocrine system disease, which seriously affects people's health with a increasing morbidity in recent years. Rhizoma Coptidis (RC), one of the most commonly used traditional Chinese medicines, has been applied to treat diabetes in clinic for thousands of years. Since scientists demonstrated that alkaloids from RC owned the amazing anti-hyperglycemia activities 30 years ago, these compounds have been widely used for the treatment of diabetes and hyperglycemia with unconspicuous toxicities and side effects. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.003DOI Listing
March 2019
4 Reads

Isolation of a spirolactone norditerpenoid as a yeast Ca signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity.

Fitoterapia 2019 Mar 2;134:290-296. Epub 2019 Mar 2.

Chemical Biology Laboratory, Iwate University, Morioka, Iwate 020-8550, Japan. Electronic address:

A different type of biologically active compound from Kuji amber (Late Cretaceous, Japan) before the K-Pg boundary [65 million years ago (Ma)] was isolated based on the growth-restoring activity of a mutant yeast involving Ca signal transduction. It was identified as a spirolactone norditerpenoid, (4R*, 5S*, 8R*, 9R*, 10S*)-14,15,16,19-tetranor-labdan-13,9-olide (1) from spectral analyses with high-resolution electron ionization mass spectrometry (HREIMS), 1D and 2D nuclear magnetic resonance (NMR). Although the planar structure of 1 is known as an artificial derivative from marrubiin, it was isolated as a natural product from Kuji amber and its structure was elucidated for the first time. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.027DOI Listing
March 2019
1 Read

New cyathane diterpenoids with neurotrophic and anti-neuroinflammatory activity from the bird's nest fungus Cyathus africanus.

Fitoterapia 2019 Mar 2;134:201-209. Epub 2019 Mar 2.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, People's Republic of China. Electronic address:

Eleven new cyathane diterpenoids, designated cyafricanins A-K (1-11), were isolated from the culture broth of the baisidiomycete Cyathus africanus (Nidulariaceae, Bird's nest fungi). Their structures were elucidated by comprehensive analysis of their NMR and HRESIMS data. Cyafricanins A (1) was found to possess an unusual 3,4-seco‑carbon skeleton. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.013DOI Listing
March 2019
1 Read
2.216 Impact Factor

Sinensiols B-G, six novel neolignans from Selaginella sinensis.

Fitoterapia 2019 Feb 28;134:256-263. Epub 2019 Feb 28.

Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China. Electronic address:

Six new neolignans, sinensiols B-G (1-6), together with three known analogues (7-9) were isolated from the whole plant of Selaginella sinensis. Their planar structures were established by comprehensive spectroscopic analyses including 1D, 2D NMR, IR and HRESIMS data. The absolute configurations of new compounds were elucidated by comparing their experimental CD spectra with known ones and using the reversed helicity rule for the L band ECD of dihydrobenzofuran neolignans. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.034DOI Listing
February 2019
1 Read

Phragmalin-type limonoids with structural diversity at D-ring from the fruit shells of Chukrasia tabularis.

Fitoterapia 2019 Feb 28;134:188-195. Epub 2019 Feb 28.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address:

Ten undescribed phragmalin-type limonoids (Chuktabularoids A-J, 1-10) and four known compounds (11-14) were isolated from the fruit shells of Chukrasia tabularis A. Juss. Their chemical structures were elucidated through a combination of HRESIMS, NMR, and ECD experiments. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.032DOI Listing
February 2019
1 Read

Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro.

Fitoterapia 2019 Feb 27;134:172-181. Epub 2019 Feb 27.

Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address:

Thuja occidentalis L. is indigenous for Northern America and commonly cultivated in Europe. Raw materials obtained from this tree are widely applied in the ethnomedicine and phytotherapy of numerous ailments, incl. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.020DOI Listing
February 2019
2 Reads

Asperfuranones A-C, 3(2H)-furanone derivatives from the fungus Aspergillus sp. and the configuration reassignment of their eighteen analogues.

Fitoterapia 2019 Feb 27;134:196-200. Epub 2019 Feb 27.

Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address:

Three undescribed 3(2H)-furanone derivatives, asperfuranones A-C (1-3), along with one known compound (4) were isolated from the Aspergillus sp. strain obtained from the intestines of centipede. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by the Snatzke's sector rules, modified Mosher's method and electronic circular dichroism (ECD) calculation. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.024DOI Listing
February 2019
2.216 Impact Factor

Naturally occurring cassane diterpenoids (CAs) of Caesalpinia: A systematic review of its biosynthesis, chemistry and pharmacology.

Fitoterapia 2019 Feb 27;134:226-249. Epub 2019 Feb 27.

Key Laboratory of Structure-Based Drug Design, Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:

Natural products, especially diterpenoids, are enriched with numerous compounds with a broad spectrum of therapeutic indications, suggesting that functional moieties serve as a core pharmacophore. Cassane diterpenoids (CAs), as the main and characteristic constituents of medical plants in the Caesalpinia genus, have been widely studied due to their bioactivities, and >450 compounds have been reported since the 1960s, including 283 compounds that have been reported in the past decade. There are five main types of structures for these compounds: tricyclic cassane diterpenoids with a fused furan ring (I) or butanolide lactone (II), tricyclic cassane diterpenoids (III), norcassane diterpenoids (IV), and other types (V). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.023DOI Listing
February 2019
4 Reads

Chemical constituents of the trunks and roots of Thuja sutchuenensis.

Fitoterapia 2019 Feb 27;134:264-269. Epub 2019 Feb 27.

Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China. Electronic address:

Five new compounds including two stilbenes, designated thujasutchins A (1) and B (2), two phenolic compounds namely thujasutchins C (3) and D (4), as well as one sesquiterpene thujasutchin E (5), were isolated from the 95% ethanolic extract from the trunks and roots of Thuja sutchuenensis. Their structures were determined by means of extensively spectroscopic analysis including UV, IR, HRESIMS, H and C NMR (COSY, HSQC, HMBC). Moreover, compounds 1, 3-5 were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.025DOI Listing
February 2019

Isoforrethins A-D, four ent-abietane diterpenoids from Isodon forrestii var. forrestii.

Fitoterapia 2019 Feb 27;134:158-164. Epub 2019 Feb 27.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address:

Four new ent-abietane diterpenoids, isoforrethins A-D (1-4), were isolated from the aerial parts of Isodon forrestii var. forrestii by a variety of chromatographic techniques. Their structures were elucidated on the basis of spectroscopic data interpretation, single crystal X-ray diffraction, and quantum chemical calculation. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.026DOI Listing
February 2019

Five new epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones from Chinese agarwood by artificial holing.

Fitoterapia 2019 Feb 28;134:182-187. Epub 2019 Feb 28.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China; Hainan Engineering Research Center of Agarwood, Haikou 571101, China. Electronic address:

Five optically active epoxy-5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone derivatives (1-5) with four chirality centers in the condensed cyclohexene ring were isolated from artificial holing agarwood originating from Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.031DOI Listing
February 2019
3 Reads
2.216 Impact Factor