3,711 results match your criteria Fitoterapia [Journal]


Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method.

Fitoterapia 2019 Feb 13. Epub 2019 Feb 13.

Key Laboratory on Protein Chemistry and Structural Biology, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, PR China. Electronic address:

The determination of the absolute configuration of natural products still faces many challenges, especially the active pharmaceutical ingredient which is trace, oily and novel structures. Currently, NMR requires chiral reagents in determining the absolute configuration; ECD involves theoretical calculations and requires chromophores. In this study, the absolute configuration of asarinin had successfully identified by using synchrotron radiation with crystalline sponge method and combining MS with NMR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.010DOI Listing
February 2019

Bioactive homogentisic acid derivatives from fruits and flowers of Miliusa velutina.

Fitoterapia 2019 Feb 12. Epub 2019 Feb 12.

Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address:

Chromatographic separation of fruits and flowers of the Thai medicinal plant, Miliusa velutina, resulted in the isolation of five new rare homogentisic acid derivatives, miliusanal (1) and miliusanones A-D (2-5), together with fifteen known secondary metabolites (6-20). Their structures were determined through the use of extensive spectroscopic data. The absolute configurations of homogentisic acid derivatives 2-7 were identified using NOESY data and a comparison of experimental and calculated ECD spectral data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.007DOI Listing
February 2019

The Amaryllidaceae as a source of antiplasmodial crinane alkaloid constituents.

Fitoterapia 2019 Feb 11. Epub 2019 Feb 11.

Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa. Electronic address:

Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to already overworked and ailing healthcare structures. Traditional medicine (TM) remains vibrant in most of these regions wherein plants often serve as the first line of defense against malaria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.009DOI Listing
February 2019

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.

Fitoterapia 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China.. Electronic address:

Five new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.013DOI Listing
February 2019

Antiproliferative ent-kaurane diterpenoids isolated from the roots of Zea mays L.

Fitoterapia 2019 Feb 11. Epub 2019 Feb 11.

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Four new ent-kaurane diterpenoid maizediterpenes A-D (1-4), along with fourteen known compounds were isolated from the roots of Zea mays (maize). Compounds 7, 15, 16 were isolated from this genus for the first time. The planar structures of the new compounds were determined by extensive analysis of their NMR and HR-ESI-MS spectra, and the absolute configurations were established on the basis of specific rotation in association with calculated ECD spectra. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183227
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.02.008DOI Listing
February 2019
1 Read

Chemistry, bioactivities, extraction and analysis of azadirachtin: State-of-the-art.

Fitoterapia 2019 Feb 6. Epub 2019 Feb 6.

Bio4Life4You, Porto, Portugal.

Azadirachta indica A. Juss. (Neem) is an Indian tree recognized for its activity as pesticide, as well as several pharmacological properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.006DOI Listing
February 2019

New knowledge about old drugs; a cardenolide type glycoside with cytotoxic effect and unusual secondary metabolites from Digitalis grandiflora Miller.

Fitoterapia 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.

Phytochemical investigation of the aerial parts of Digitalis grandiflora Miller (Plantaginaceae) led to the isolation of an undescribed cardenolide type glycoside digigrandifloroside (1) along with five known compounds, rengyoside A (2), rengyoside B (3), cleroindicin A (4), salidroside (5), and cornoside (6), from its aqueous fraction of methanolic extract. Structures of the isolated compounds were determined by means of spectroscopic techniques. 1-6 were isolated for the first time from D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.001DOI Listing
February 2019

The antagonism between apigenin and protoapigenone to the PDK-1 target in Macrothelypteris torresiana.

Fitoterapia 2019 Feb 4;134:14-22. Epub 2019 Feb 4.

Conform Pharm Engineering Center, Humanwell Healthcare (group) Co. Ltd, Gaoxing Avenue, Biolake park, Wuhan, China. Electronic address:

Apigenin and protoapigenone that both have the activities against various cancer cell lines co-exist in Macrothelypteris torresiana, while the extracts of M. torresiana couldn't achieve the fine anti-tumor effects for the existence of potent anti-tumor compounds. This study disclosed an antagonism between the two compounds on the protein level to elucidate the paradox. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.005DOI Listing
February 2019

Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action.

Fitoterapia 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, CZ-323 00 Pilsen, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.002DOI Listing
February 2019

Caesalminaxins O-T, cassane diterpenoids from the seeds of Caesalpinia minax and their anti-inflammation.

Fitoterapia 2019 Feb 4. Epub 2019 Feb 4.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:

Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1-6), together with 28 known compounds (7-34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded H NMR signal was the first example in cassane diterpenoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.004DOI Listing
February 2019
1 Read

Antioxidant constituents of chrysanthemum 'jinsidaju' cultivated in Kaifeng.

Fitoterapia 2019 Feb 4;134:39-43. Epub 2019 Feb 4.

Institute of Pharmacy, College of Pharmacy, Henan University, Kaifeng 475004, China; Kaifeng Key Lab for Application of Local Dendranthema morifolium in Food & Drug, Kaifeng 475004, China. Electronic address:

Dendranthema morifolium cv. 'jinsidaju', cultivated only in Kaifeng, has been eaten for more than 1000 years. During the antioxidant-activity-guided studies on its chemistry and health care function, two new bisabolane-type sesquiterpenes, (6R,7R)-7-hydroxybisabol-2,9E,11-triene-4-one (jinsidajuol A, 1) and (6R,7R)-7-hydroxy-11-methoxybisabol-2,9E-diene-4-one (jinsidajuol B, 2), and thirteen known compounds (3-15) were isolated from the flowers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.003DOI Listing
February 2019
1 Read

Fusariumins C and D, two novel antimicrobial agents from Fusarium oxysporum ZZP-R1 symbiotic on Rumex madaio Makino.

Fitoterapia 2019 Jan 29;134:1-4. Epub 2019 Jan 29.

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Fusarium oxysporum ZZP-R1 derived from coastal plant Rumex madaio Makino, one traditional Chinese medicine used as a treatment of inflammation and toxication, yielded two novel compounds, fusariumins C (1) and D (2). Chemical structures of 1 and 2 were respectively determined as one meroterpene with cyclohexanone moiety and a sesquiterpene ester with a conjugated triene and an unusual oxetene ring by a combination of spectroscopic methods, including 1D and 2D NMR, mass spectrometry, and optical rotation analysis, as well as by comparison with literature data. Bioassay results indicated that compound 1 displayed potent activity against Staphyloccocus aureus with an MIC value of 6. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183236
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.016DOI Listing
January 2019
1 Read

The protective effects of vernicilignan A, a new flavonolignan isolated from Toxicodendron vernicifluum on SH-SY5Y cells against oxidative stress-induced injury.

Fitoterapia 2019 Jan 25. Epub 2019 Jan 25.

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

In this study, a new flavonolignan vernicilignan A was isolated from Toxicodendron vernicifluum. The neuroprotective effects of this compound against HO induced cell injury in SH-SY5Y cells were evaluated by MTT assay and LDH release assay. Vernicilignan A dose-dependently attenuated the cell injury and LDH release induced by HO in SH-SY5Y cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183223
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.011DOI Listing
January 2019
2 Reads

Hibiscus acid from Hibiscus sabdariffa (Malvaceae) has a vasorelaxant effect on the rat aorta.

Fitoterapia 2019 Jan 25;134:5-13. Epub 2019 Jan 25.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, UK. Electronic address:

Hibiscus sabdariffa (Malvaceae) is a plant that is widely recognised for its antihypertensive properties; however the constituent(s) responsible for this biological activity are presently unknown. The aim of this study was to identify the potential compounds that are responsible for the vasorelaxant activity of H. sabdariffa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.012DOI Listing
January 2019

Lewis acid-mediated skeleton transformation of Euphorbia diterpenes: From lathyrane to euphoractane and myrsinane.

Fitoterapia 2019 Jan 25;133:212-218. Epub 2019 Jan 25.

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China; Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. Electronic address:

Natural euphoractane and myrsinane diterpene skeletons, together with an unnatural 5/7/7/4 fused-ring diterpene skeleton were furnished via BF·EtO-mediated transformation of lathyrane-type diterpene, Euphorbia factor L1. The skeleton transformation process was mainly involved in the cascade oxirane-opening (cyclopropane-opening)/oxe-Micheal addition reaction. The structures of three diterpenes were confirmed by comprehensive spectra analysis and single crystals X-ray diffraction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.015DOI Listing
January 2019

Eight new triterpenoid saponins with antioxidant activity from the roots of Glycyrrhiza uralensis Fisch.

Fitoterapia 2019 Jan 25;133:186-192. Epub 2019 Jan 25.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

Eight new triterpenoid saponins (1-8), were isolated from the roots of Glycyrrhiza uralensis Fisch., together with 10 known triterpenoid saponins (9-18). Their structures were determined by analysis of their spectroscopic data and comparison with the reference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.014DOI Listing
January 2019

Biological activity, phytochemistry and traditional uses of genus Lobelia (Campanulaceae): A systematic review.

Fitoterapia 2019 Jan 18;134:23-38. Epub 2019 Jan 18.

Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Avenida Pref. Lothário Meissner, 632, Curitiba, PR CEP.: 80210-170, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.021DOI Listing
January 2019
1 Read

Melosuavine I, an apoptosis-inducing bisindole alkaloid from Melodinus suaveolens.

Fitoterapia 2019 Jan 18;133:175-179. Epub 2019 Jan 18.

School of Biological Sciences and Technology, University of Jinan, Jinan 250022, PR China. Electronic address:

A new bisindole alkaloid, melosuavine I (1) possessing an aspidosperma-aspidosperma dimeric skeleton, was isolated from the leaves of Melodinus suaveolens. The structure with absolute configuration of 1 was elucidated by a combination of MS, NMR and computational methods. MTT assays indicated that 1 exhibited significant cytotoxicity on human breast cancer BT549 cells with an IC value of 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183220
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.026DOI Listing
January 2019
4 Reads

Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida.

Fitoterapia 2019 Jan 17. Epub 2019 Jan 17.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

The investigation of the ethanol extract of the seeds of Crataegus pinnatifida led to the isolation of seven new 8-O-4' type sesquineolignans crasesquineolignan A-G (1-7), along with a reported analogue, leptolepisol B (8). The chemical structures of these compounds were elucidated based on complex analysis of their MS, 1D and 2D NMR data. All the isolated compounds were tested for their neuroprotective effects against the damage of human neuroblastoma SH-SY5Y cells induced by HO, and most of them showed significant neuroprotective activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.008DOI Listing
January 2019

Seven new guanacastane-type diterpenoids from the fungus Verticillium dahliae.

Fitoterapia 2019 Jan 16;133:219-224. Epub 2019 Jan 16.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China. Electronic address:

Seven new guanacastane-type diterpenoids, namely dahlianes E-K (1-7), and three known ones (8-10) were isolated from the cultures of the fungus Verticillium dahliae. Their structures were established by extensive spectroscopic data analysis along with Rh(OCOCF)- and Mo(OAc)-induced electronic circular dichroism (ECD) experiment. Dahliane G showed an 80-fold potentiation effect on the sensitization of doxorubicin at the concentration of 15 μM when screening the reversal activity on doxorubicin-resistant human breast cancer cells (MCF-7/DOX). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183236
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.009DOI Listing
January 2019
1 Read

Aquilariaenes A-H, eight new diterpenoids from Chinese eaglewood.

Fitoterapia 2019 Jan 17;133:180-185. Epub 2019 Jan 17.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Medicinal Natural Products, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. Electronic address:

Aquilariaenes A-H (1-8), eight new diterpenoids and nor-diterpenoids (1-8) belonging to abietane or pimarane, were isolated from the petroleum ether extract of Chinese eaglewood. Their structures were elucidated on the basis of extensive spectroscopic methods including HRESIMS, IR, 1D and 2D NMR spectroscopic data analyses. Antidepressant activities of isolates for in vitro inhibition of serotonin and norepinephrine reuptake in rat brain synaptosomes were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.010DOI Listing
January 2019
1 Read

Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae).

Fitoterapia 2019 Jan 14;133:171-174. Epub 2019 Jan 14.

Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, Australia.

The bioassay-guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata led to the discovery of three new 4-phenylcoumarins, costatamins A - C (1-3). The structures were determined by detailed spectroscopic analysis. Costatamins A - C were evaluated for their inhibitory effects on (a) NO production and (b) TNF-α release in RAW 264. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.004DOI Listing
January 2019

Hirtellina lobelii DC. essential oil, its constituents, its combination with antimicrobial drugs and its mode of action.

Fitoterapia 2019 Jan 14;133:130-136. Epub 2019 Jan 14.

CNRS, Institut de Chimie des Substances Naturelles (ICSN), UPR2301, Université Paris-Sud, 1 avenue de la terrasse, 91198 Gif-sur-Yvette, France; Sorbonne Université, CNRS, Laboratoire de Biodiversité et Biotechnologie Microbienne, USR3579, Observatoire Océanologique, 66650, Banyuls-sur-mer, France. Electronic address:

With the goal of unravelling antimicrobial agents and mixtures inspired by plant defences, we investigated the antibacterial and antifungal efficacy of Hirtellina lobelii DC. essential oil (EO), both alone and in combination with antimicrobial drugs. Hirtellina lobelii DC. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183213
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.001DOI Listing
January 2019
4 Reads

Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities.

Fitoterapia 2019 Jan 14;133:146-149. Epub 2019 Jan 14.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. Electronic address:

Three new hopane-type triterpenoids (1-3), fern-7(8)-en-19α, 28-diol (1), pteron-14-ene-7α,19α,28-triol (2) and 3β,4α,25-trihydroxyfilican (3), were isolated from the aerial parts of Adiantum capillus-veneris. Their structures were determined by NMR spectroscopic and mass spectrometric data. Compounds 2 and 3 exhibited remarkable antifungal activity against Helminthosporium maydis and Alternaria alternata with MIC values of 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.006DOI Listing
January 2019
1 Read

Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation.

Fitoterapia 2019 Jan 14;133:137-145. Epub 2019 Jan 14.

School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China. Electronic address:

Indoleamine 2,3-dioxygenase (IDO) is one of the important targets for cancer immunotherapy through tryptophan pathway. Recently it has being paid great attention to search potent and safe IDO inhibitor from small-molecule compounds. Picrasma quassioides is a kind of medicinal plant abundant with tryptophan-derived indole alkaloids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.005DOI Listing
January 2019
3 Reads

Ent-kauranes from the Chinese Excoecaria agallocha L. and NF-κB inhibitory activity.

Fitoterapia 2019 Jan 14;133:159-170. Epub 2019 Jan 14.

School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, PR China. Electronic address:

Eleven undescribed ent-kauranes, named agallochanins A-K, were isolated from the stems and twigs of the Chinese semi-mangrove plant, Excoecaria agallocha L.. The absolute configurations of these diterpenoid compounds, except for the chirality of C-4 in agallochanin H, were unequivocally determined by HR-ESIMS, extensive NMR investigations, single-crystal X-ray diffraction analyses with Cu Kα radiation, quantum-chemical electronic circular dichroism (ECD) calculations, the comparison of experimental ECD spectra, and the modified Mosher's α-methoxy-α-(trifluoromethyl)phenylacetyl (MTPA) ester method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.01.007DOI Listing
January 2019
1 Read

Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.

Fitoterapia 2019 Jan 14;133:193-199. Epub 2019 Jan 14.

Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Two new furoquinoline alkaloids, maculine B (1) and kokusaginine B (2) and one new dihydrooxazole alkaloid, veprisazole (3), along with four known compounds namely, N-methyl-3-methoxyrutaecarpine (4), flindersiamine (5), skimmianine (6) and tilianin (7) were isolated from the methanol extract of the stem bark of Araliopsis soyauxii Engl. by various chromatographic methods. Their structures were determined using spectrometry and spectroscopic techniques including NMR and MS. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183176
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.003DOI Listing
January 2019
3 Reads

Gambogenic acid triggers apoptosis in human nasopharyngeal carcinoma CNE-2Z cells by activating volume-sensitive outwardly rectifying chloride channel.

Fitoterapia 2019 Jan 14;133:150-158. Epub 2019 Jan 14.

Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China. Electronic address:

Gambogenic acid (GNA) is one of the main components of Gamboge, and its anti-cancer effects have been well confirmed by previous researches. Nasopharyngeal carcinoma (NPC) has not been thoroughly studied, and the pathogenesis of NPC is unclear. Scientists have neither discovered effective therapies nor achieved a desirable prognosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183160
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.01.002DOI Listing
January 2019
3 Reads

Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungus Penicillium sp. YPGA11.

Fitoterapia 2018 Dec 31;133:120-124. Epub 2018 Dec 31.

Pharmaceutical College, Henan University, Kaifeng 475004, People's Republic of China; Eucommia ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, People's Republic of China. Electronic address:

Twelve terpenoids, including two new 3,5-dimethylorsellinic acid-based meroterpenoids (1 and 2) and two new monoterpenoids (11 and 12), were obtained from the deep-sea fungus Penicillium sp. YPGA11. Their structures were determined by extensive analyses of spectroscopic data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental and calculated ECD spectra. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183221
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.022DOI Listing
December 2018
1 Read

New compounds of Siolmatra brasiliensis and inhibition of in vitro protein glycation damage.

Fitoterapia 2018 Dec 31;133:109-119. Epub 2018 Dec 31.

Programa de Pós-graduação em Química, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.

Twenty compounds were isolated from the hydroethanolic extract of the stems of Siolmatra brasiliensis, five flavonoids, two lignans, one glucosyl phytosterol, seven nor-cucurbitacins, one new phenolic derivative named siolmatrin (1) and four new dammarane-type saponins named siolmatrosides II-V (2-5), the structures of the compounds were assigned by means of 1D and 2D NMR experiments and HRESIMS of the natural compounds and some acetyl derivatives. The effects of the crude hydroethanolic extract (SbExt) and the ethyl acetate fraction (SbEtAc) of Siolmatra brasiliensis stems on the formation of advanced glycation end-products (AGEs) were also investigated. In the in vitro model system of protein glycation using bovine serum albumin (BSA) and glucose, addition of SbExt or SbEtAc inhibited the formation of fluorescent AGEs, in parallel to minor levels of fructosamine (SbEtAc) and markers of tyrosine and tryptophan oxidation (SbExt and SbEtAc). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.023DOI Listing
December 2018
9 Reads

Flueggenoids A - E, new dinorditerpenoids from Flueggea virosa.

Fitoterapia 2018 Dec 31;133:96-101. Epub 2018 Dec 31.

Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address:

A phytochemical investigation on the twigs and leaves of Flueggea virosa (Euphorbiaceae) led to the isolation of flueggenoids A - E (1-5), five new 13-methyl-ent-podocarpanes, together with eleven known compounds (6-16). Their structures and absolute configurations were elucidated on the basis of extensive MS and NMR data analysis, and/or single-crystal X-ray diffraction, time-dependent density functional theory (TDDFT)-based electronic circular dichroism (ECD) calculations, and chemical transformation. All isolates were evaluated for anti-HCV activity, the results showed that terpenoids of F. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183214
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.025DOI Listing
December 2018
1 Read
2.216 Impact Factor

Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer.

Fitoterapia 2018 Dec 31;133:102-108. Epub 2018 Dec 31.

Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China. Electronic address:

Gossypol is a yellow polyphenol isolated from cotton seeds. It has the antitumor activity and it is being tested to treat prostate cancer. However, its underlying mechanisms are still not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.024DOI Listing
December 2018
2.216 Impact Factor

Metabolites identification of (+)-usnic acid in vivo by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Fitoterapia 2018 Dec 31;133:85-95. Epub 2018 Dec 31.

Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei 050017, China. Electronic address:

(+)-usnic acid (UA) is an active natural phenolic acid ingredient originating from Chinese traditional Tibetan herb. Usnea acid is expected to become a new agent for anticancer and remarkable antitumor. To reveal its metabolic profile, metabolites identification of UA in vivo was studied using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) in this present study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.020DOI Listing
December 2018
3 Reads
2.216 Impact Factor

Pyrone derivatives from Helichrysum italicum.

Fitoterapia 2018 Dec 30;133:80-84. Epub 2018 Dec 30.

Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address:

Chemical investigation of aerial parts of Helichrysum italicum yielded two new pyrone derivatives (1 and 2) along with ten known compounds. The structures of the new compounds were established by 1D and 2D NMR spectra as well as by HRESIMS data. Compound 1 represented a rare dimer of substituted α- and γ-pyrone units. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183186
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.018DOI Listing
December 2018
3 Reads

Two pairs of enantiomeric propylated flavonoids and a new lignan from the aerial parts of Abrus precatorius.

Fitoterapia 2018 Dec 30;133:125-129. Epub 2018 Dec 30.

Program for Natural Products Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. Electronic address:

Two pairs of novel enantiomeric flavonoids (1a, 1b and 2a, 2b), along with one new lignan (3), were isolated from the aerial parts of Abrus precatorius. All of these enantiomeric flavonoids featured an unprecedented propylated flavonoid skeleton representing a new family of flavonoid, and the new lignan was found to have an attractive arachidate ester side chain. Their structures were extensively elucidated by means of detailed NMR and mass spectroscopic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.019DOI Listing
December 2018
2.216 Impact Factor

Target discovery of chlorogenic acid derivatives from the flower buds of Lonicera macranthoides and their MAO B inhibitory mechanism.

Fitoterapia 2018 Dec 29. Epub 2018 Dec 29.

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Chlorogenic acids (CGAs), exhibiting health benefits in many foods, also played an important role for their broad bioactive properties in nature. Obtaining more diverse CGAs was helpful to discover their potential edible and medical value. In this study, 11 CGAs, including four new (1-4) and seven known compounds (5-11), were obtained from the flower buds of Lonicera macranthoides Miq. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.009DOI Listing
December 2018

Study of antiopisthorchiasis activity of sesquiterpene lactones and their derivatives.

Authors:
S M Adekenov

Fitoterapia 2018 Dec 23;133:200-211. Epub 2018 Dec 23.

JSC International Research and Production Holding "Phytochemistry", Karaganda, Kazakhstan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.017DOI Listing
December 2018

Cytotoxic and antibacterial triterpenoids from the roots of Morinda officinalis var. officinalis.

Fitoterapia 2018 Dec 21;133:56-61. Epub 2018 Dec 21.

School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. Electronic address:

Seven new pentacyclic triterpenoids including six ursane-type, marinoids A-F (1-6), and one oleanane-type, marinoid G (7), along with five known analogues (8-12), were separated from the roots of Morinda officinalis var. officinalis. Their structures were assigned by spectroscopic means especially analysis of 2D NMR data, with the absolute configurations of 1 and 2 being determined via comparison of their experimental ECD spectra with the computed ones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.011DOI Listing
December 2018

Cytotoxic limonoids from the bark of Walsura cochinchinensis.

Fitoterapia 2018 Dec 19;133:75-79. Epub 2018 Dec 19.

Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam. Electronic address:

Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.11.008DOI Listing
December 2018
1 Read

homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum.

Fitoterapia 2018 Dec 18;133:43-50. Epub 2018 Dec 18.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China. Electronic address:

Hookeriones I-Q (1-9), nine new homo-adamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum hookerianum, along with twenty known analogues. These structures were determined on the basis of comprehensive NMR and MS spectroscopic data. Comprehensive analysis of the NMR data revealed the correlations between the configuration of H-18 and H-28 and the chemical shifts of related signals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.014DOI Listing
December 2018

Lignans with melanogenesis effects from Premna serratifolia wood.

Fitoterapia 2018 Dec 17;133:35-42. Epub 2018 Dec 17.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan. Electronic address:

Three new lignoids, premnan A (1), premnan B (2), and tauntangyiol C (3), were isolated from Premna serratifolia wood, a traditional cosmetic plant in Myanmar, together with a new lignoid, premnan C (4) assumed to be an artifact, one natural new lignoid (5), and three known lignoids (6-8). The structures of the new compounds 1-4 were elucidated based on 1D and 2D NMR, IR spectroscopy, and HRESIMS. The absolute configurations of 1-4 were also determined by optical rotation, circular dichroism (CD) data analyses, and comparisons with the reported literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.008DOI Listing
December 2018

Diverse epoxy grayanane diterpenoids with analgesic activity from the roots of Pieris formosa.

Fitoterapia 2018 Dec 17;133:29-34. Epub 2018 Dec 17.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China. Electronic address:

In our on-going study to investigate components with analgesic activity, eight new grayanane diterpenoids, epoxypieristoxins A-H (1-8), along with one known compound (9) were isolated from the roots of Pieris formosa. Their structures with absolute configurations were characterized by a series of spectroscopic methods and X-ray diffraction. Notably, compounds 1-5 represented the first example of natural grayanane diterpenoids possessed a 10,14-epoxy group. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183187
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.007DOI Listing
December 2018
7 Reads

A new byciclic monoterpene glucoside and a new biflavone from the male reproduction organs of Wollemia nobilis.

Fitoterapia 2018 Dec 17;133:62-69. Epub 2018 Dec 17.

Dipartimento di Biologia Ambientale, Università di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy.

In this work, the fifth part of an ongoing phytochemical study on Wollemia nobilis was reported. The attention was now focused on the male reproduction organs of which the content in both primary and secondary metabolites was analyzed. Twenty compounds, belonging to seven different classes of natural compounds, were identified from the ethanolic extract by means of Column Chromatography and NMR and MS Spectroscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.012DOI Listing
December 2018

An indirect competitive enzyme-linked immunosorbent assay toward the standardization of Pueraria candollei based on its unique isoflavonoid, kwakhurin.

Fitoterapia 2018 Dec 17;133:23-28. Epub 2018 Dec 17.

Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Kwakhurin (Kwa) is a plant secondary metabolite solely present in Pueraria candollei var. mirifica (P. candollei), which has long been used as a Thai traditional herb for estrogen replacement therapy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183197
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.010DOI Listing
December 2018
1 Read
2.216 Impact Factor

Coumarinolignoids and lignanoids from the stems and leaves of Sapium discolor.

Fitoterapia 2018 Dec 18;133:17-22. Epub 2018 Dec 18.

College of Pharmacy, Guilin Medical University, Guilin 541004, People's Republic of China. Electronic address:

Two new coumarinolignoids, sapiumins D (1) and E (2), a new lignanoid, lariciresinol 9'-benzoate (3), together with six known coumarinolignoids (4-9) and eight known lignanoids (10-17), were isolated from the stems and leaves of Sapium discolor. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and single crystal X-ray diffraction experiments. Compounds 5, 10, 11, and 13 significantly inhibited nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells, with IC values in the range of 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.013DOI Listing
December 2018

Dimeric 2-(2-phenylethyl)chromones from the agarwood of Aquilaria crassna in Laos.

Fitoterapia 2018 Dec 17;133:12-16. Epub 2018 Dec 17.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; Hainan Engineering Research Center of Agarwood, Haikou 571101, China. Electronic address:

Four new dimeric 2-(2-phenylethyl)chromones (1-4) were isolated from the agarwood of Aquilaria crassna in Laos. All structures were determined based on extensive spectroscopic methods including IR, UV, 1D and 2D NMR, ECD, and HRMS. The structures of compounds 1-3 were characterized by two C-O-C linkages between the two chromone moieties, while compound 4 featured one C-O-C linkage and one CC bond connecting with two chromone moieties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.006DOI Listing
December 2018
1 Read
2.216 Impact Factor

Amino acid-sesquiterpene lactone conjugates from the aerial parts of Centaurea pungens and evaluation of their antimicrobial activity.

Fitoterapia 2018 Dec 14;133:51-55. Epub 2018 Dec 14.

Università degli Studi di Salerno, Dipartimento di Farmacia, Via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy. Electronic address:

Two new amino acid-sesquiterpene lactone conjugates, named centaureolide A (1) and centaureolide B (2) along with a germacrane derivative (3), five flavonoids (4-8) and one quinic acid derivative (9) have been isolated from the aerial parts of Centaurea pungens (Asteraceae). Their structures were established by a combination of one- and two-dimensional NMR techniques, and mass spectrometry. The never reported sesquiterpene lactones have been determined as germacrane derivatives (1 and 2) characterized by the unusual occurrence of a proline moiety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.001DOI Listing
December 2018
4 Reads

Three new capnosane-type diterpenoids from the South China Sea soft coral Lobophytum sp.

Fitoterapia 2018 Dec 13;133:70-74. Epub 2018 Dec 13.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address:

Three new diterpenoids with an unusual capnosane skeleton named lobophytrols A-C (1-3) were isolated from the South China Sea soft coral Lobophytum sp. along with one known related diterpene, (11S,12S,1E,3E,7E)-11,12-epoxycembra-1,3,7-triene (7). Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183198
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.12.003DOI Listing
December 2018
4 Reads

Antibacterial anthraquinone dimers from marine derived fungus Aspergillus sp.

Fitoterapia 2018 Dec 10;133:1-4. Epub 2018 Dec 10.

School of Pharmacy, Nantong University, Nantong 226001, PR China. Electronic address:

As a continue investigation of the bioactive secondary metabolites from marine derived fungi, two new anthraquinone dimers (1, 2), along with three known anthraquinones (3-5) and two known xanthones (6, 7) were isolated from the marine-derived fungus Aspergillus versicolor. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and comparison with reported ones. Among them, compounds 1 and 2 were identified as anthraquinone dimers which dimerized by a rare C-O-C ether linkage, and both of them showed selective antibacterial activity against Gram-positive Staphylococcus aureus; whilst compound 6 exhibited moderate cytotoxicity against human cancer cell lines. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X183178
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2018.11.015DOI Listing
December 2018
12 Reads

Lactone ring-opening seco-guaianolide involved heterodimers linked via an ester bond from Artemisia argyi with NO inhibitory activity.

Fitoterapia 2019 Jan 4;132:94-100. Epub 2018 Dec 4.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. Electronic address:

Investigation into the chemical diversity of Artemisia argyi led to the discovery of four new (1-4) and one known (5) guaianolide sesquitenpenoid dimers linked via ester bond, and five other known mono-sesquiterpenoids (6-10). Their structures were determined via extensive spectroscopic data, and the absolute configurations of these compounds were elucidated by calculated ECD analysis and chemical method. The dimeric sesquiterpenoids exhibited NO production inhibitory activity with IC values ranging from 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2018.12.004DOI Listing
January 2019
2.216 Impact Factor