2,302 results match your criteria First Trimester Pregnancy Loss


Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences.

Am J Obstet Gynecol 2020 May 24. Epub 2020 May 24.

Second Department of Obstetrics and Gynecology, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateio Hospital of Thessaloniki, Greece. Electronic address:

Objective: Cytomegalovirus (CMV) infection is the most frequent congenital infection and a major cause of long-term neurological morbidity. The aim of this meta-analysis was to calculate the pooled rates of vertical transmission and fetal consequences according to the timing of primary maternal infection.

Data Sources: MEDLINE, Scopus, Cochrane Library and grey literature sources were searched from inception until January 2020. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.038DOI Listing

Serum and placental periostin levels in women with early pregnancy loss.

J Reprod Immunol 2020 May 15;140:103138. Epub 2020 May 15.

Department of Gynecology and Obstetrics, Baskent University, Konya, Turkey.

Objectives: Periostin is secreted from the placenta in the embryonic period and it is emphasized that it may be involved in endometrial implantation. In this study, we aimed to investigate periostin serum levels and placental tissue expression in first trimester pregnancy losses.

Study Design: In this prospective case-control study, 30 patients who underwent dilatation and curettage with first trimester spontaneous abortion (<10 weeks of gestation) were included in the study group and 30 patients who had voluntary pregnancy termination (<10 gestational weeks) were included in the control group. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103138DOI Listing

Is it time for routine prenatal serological screening for congenital cytomegalovirus?

Prenat Diagn 2020 May 27. Epub 2020 May 27.

EA Fetus, Paris Descartes Université, Université de Paris, Paris, France.

Congenital CMV infection (cCMV) is the most prevalent congenital infection, main non-genetic cause of sensorineural hearing loss (SNHL) and major cause of neurological disability. Despite the burden of cCMV, no Public Health body recommends universal serology screening in pregnancy. This was explained by gaps in knowledge of epidemiology, diagnosis, prognosis and the absence of any validated treatment. Read More

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http://dx.doi.org/10.1002/pd.5757DOI Listing

New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism.

Clin Endocrinol (Oxf) 2020 May 21. Epub 2020 May 21.

Biochemistry and Genetic Laboratory, Federative Institute of Biology, CHU Toulouse, Inserm UMR 1048, Team 6, Institute of Metabolic and Cardiovascular Diseases (I2MC), CHU Rangueil, Toulouse, France.

Context: Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.

Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for thyrotoxicosis with increased fT3 and fT4 concentrations and low TSH levels without anti-TSH receptor antibody. Thyrotoxicosis improved spontaneously during the 2nd trimester and persisted at the 3rd trimester. Read More

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http://dx.doi.org/10.1111/cen.14215DOI Listing

The experience and outcomes of a specialised preterm birth clinic in New Zealand.

Aust N Z J Obstet Gynaecol 2020 May 18. Epub 2020 May 18.

Liggins Institute, The University of Auckland, Auckland, New Zealand.

Background: A greater understanding of the risk factors for spontaneous preterm birth and the importance of risk stratification to guide interventions has led to the introduction of preterm birth prevention clinics.

Aim: To evaluate the experience and outcomes of the first specialised preterm birth clinic in New Zealand.

Materials And Methods: This observational study reviewed pregnancies cared for in a preterm birth clinic from 2013 to 2018. Read More

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http://dx.doi.org/10.1111/ajo.13176DOI Listing

Fetal spina bifida in a pregnant woman following omega gastric bypass: Case report and literature review.

Int J Surg Case Rep 2020 May 11;70:137-139. Epub 2020 May 11.

Department of Digestive Surgery, Centre Hospitalier de Saint-Denis, 2 rue du Docteur Delafontaine, 93200 Saint-Denis, France. Electronic address:

Introduction: Bariatric surgery has been increasingly popular during the last years because of its proven efficacy on obesity and related complications. However, nutrient deficiency is common after surgery, in particular after Roux-en-Y gastric bypass (RYGB) or omega gastric bypass (OGB), due to iatrogenic malabsorption. All vitamins and minerals could be involved, including vitamin B9 which plays an important role in the prevention of neural tube defects during pregnancy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229410PMC

Home Collection of Products of Conception: Can Chromosomal Analysis be Obtained?

J Gynecol Obstet Hum Reprod 2020 May 14:101810. Epub 2020 May 14.

Oregon Health & Science University Portland, OR, USA.

Introduction: The majority of early pregnancy losses are due to chromosomal abnormalities, which can be evaluated by testing the products of conception (POCs). Traditionally, a dilation and curettage (D&C) is recommended to patients to obtain suitable tissue for analysis. This case series sought to determine whether patients with first-trimester pregnancy losses can successfully obtain analysis of POCs if they pass tissue with expectant management or misoprostol, rather than D&C. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101810DOI Listing

Reproductive outcomes of cesarean scar pregnancies pretreated with methotrexate and uterine artery embolization prior to curettage.

Taiwan J Obstet Gynecol 2020 May;59(3):381-386

Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To evaluate the reproductive outcomes of cesarean scar pregnancy (CSP) pretreated with methotrexate (MTX) and uterine artery embolization (UAE) prior to curettage.

Materials And Methods: The medical records of patients with CSP who were pretreated with MTX and UAE prior to curettage in our institute from January 2013 to December 2015 were collected and retrospectively reviewed.

Results: A total of 53 patients were eligible for further analysis. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.03.008DOI Listing

Differentiating pregnancies near the uterotubal junction (angular, cornual, and interstitial): a review and recommendations.

Fertil Res Pract 2020 4;6. Epub 2020 May 4.

Department of Obstetrics, Gynecology and Women's Health, MU Institute for Women's Health Research, University of Missouri School of Medicine, 500 North Keene Street, Columbia, MO 65201 USA.

Eccentrically located intracavitary pregnancies, which include pregnancies traditionally termed as cornual and/or angular, have long presented complex diagnostic and management challenges given their inherent relationship to interstitial ectopic pregnancies. This review uses the existing literature to discriminate among interstitial, cornual, and angular pregnancies. Current arguments propose the outright abandonment of the terms cornual and angular may be justified in favor of the singular term, eccentric pregnancy. Read More

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http://dx.doi.org/10.1186/s40738-020-00077-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199330PMC

Comparison of Different Anticoagulation Regimens Regarding Maternal and Fetal Outcomes in Pregnant Patients With Mechanical Prosthetic Heart Valves (from the Multicenter ANATOLIA-PREG Registry).

Am J Cardiol 2020 Apr 19. Epub 2020 Apr 19.

Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey; Faculty of Health Sciences, Ardahan University, Ardahan, Turkey.

Mechanical prosthetic heart valves (MPHVs) are highly thrombogenic, and a pregnancy-induced procoagulant status increases the risk of MPHV thrombosis. Despite numerous case reports, 2 major registries and meta-analyses/systematic reviews, optimal anticoagulation therapy during pregnancy remains controversial. The goal of this study was to evaluate different anticoagulation regimens in pregnant patients with MPHVs. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.010DOI Listing

Can neutrophil-lymphocyte and platelet-lymphocyte ratios predict threatened abortion and early pregnancy loss?

Ginekol Pol 2020 ;91(4):210-215

Erzincan Binali Yildirim University, Erzincan University Gynecology and Obstetric Depertmant, Erzincan, Turkey.

Objectives: An investigation of the importance of hematological inflammatory markers on the prognosis of first trimester pregnancies and their role in predicting threatened abortion and early pregnancy loss.

Material And Methods: This study was carried out in the Obstetrics and Gynecology Department of the Faculty of Medicine in our University between January 2018 and May 2019. Three-hundred individuals, 100 of them diagnosed with early pregnancy loss (EPL), 100 diagnosed with threatened abortion (TA) and 100 healthy control patients (HC), participated in the study. Read More

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http://dx.doi.org/10.5603/GP.2020.0042DOI Listing
January 2020

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis.

Hum Reprod Update 2020 May 2. Epub 2020 May 2.

Department of Gynaecology and Obstetrics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.

Background: Although spontaneous miscarriage is the most common complication of human pregnancy, potential contributing factors are not fully understood. Advanced maternal age has long been recognised as a major risk factor for miscarriage, being strongly related with fetal chromosomal abnormalities. The relation between paternal age and the risk of miscarriage is less evident, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to miscarriage. Read More

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http://dx.doi.org/10.1093/humupd/dmaa010DOI Listing

Risk of pregnancy loss in patients exposed to mycophenolate compared to azathioprine: A retrospective cohort study.

Pharmacoepidemiol Drug Saf 2020 Apr 29. Epub 2020 Apr 29.

Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.

Purpose: To evaluate the relative risk of pregnancy loss associated with mycophenolate (MPA) vs azathioprine (AZA) use.

Methods: We conducted a retrospective cohort study using the IBM MarketScan Research Databases (2005-2015). Patients with ≥1 MPA or AZA prescription claim during the first trimester were included. Read More

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http://dx.doi.org/10.1002/pds.5017DOI Listing
April 2020
2.939 Impact Factor

Early maternal weight gain as a risk factor for SGA in pregnancies with hyperemesis gravidarum: a 15-year hospital cohort study.

BMC Pregnancy Childbirth 2020 Apr 28;20(1):255. Epub 2020 Apr 28.

Department of Clinical Science, University of Bergen, Jonas Lies vei 72, 5053, Bergen, Norway.

Background: Inadequate maternal weight gain increases the risk of small-for-gestational age (SGA) infants. Women with hyperemesis gravidarum (HG) are at risk of significant early pregnancy weight loss and insufficient total pregnancy weight gain. Recent studies have implied that weight gain during the first half of pregnancy is more crucial to pregnancy outcome than total weight gain. Read More

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http://dx.doi.org/10.1186/s12884-020-02947-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189646PMC

Accuracy of prenatal ultrasound screening to identify fetuses infected by cytomegalovirus who will develop severe long-term sequelae.

Ultrasound Obstet Gynecol 2020 Apr 27. Epub 2020 Apr 27.

EA 73-28, Paris Descartes University, Sorbonne Paris Cité, Paris, 75005, France.

Objectives: To compare the ability to identify infected fetuses who will develop long-term sequelae, of routine ultrasound detailed examination performed without the knowledge of maternal serology and the fetal status to that of targeted prenatal imaging performed in prenatal diagnosis units in known cases of fetal infection.

Methods: All prenatal imaging reports were collected for 256 children with congenital CMV in a registered cohort between 2013 and 2017 (NCT01923636). All pregnancies underwent detailed fetal ultrasound examination at 20-24 and 30-34 weeks' as part of routine antenatal care. Read More

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http://dx.doi.org/10.1002/uog.22056DOI Listing

Management of early pregnancy loss with mifepristone and misoprostol: clinical predictors of treatment success from a randomized trial.

Am J Obstet Gynecol 2020 Apr 17. Epub 2020 Apr 17.

Division of Family Planning, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Early pregnancy loss is a common event in the first trimester, occurring in 15%-20% of confirmed pregnancies. A common evidence-based medical regimen for early pregnancy loss uses misoprostol, a prostaglandin E1 analog, with a dosage of 800 μg, self-administered vaginally. The clinical utility of this regimen is limited by suboptimal effectiveness in patients with a closed cervical os, with 29% of patients experiencing early pregnancy loss requiring a second dose after 3 days and 16% of patients eventually requiring a uterine aspiration procedure. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.04.006DOI Listing

Low-dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss.

Int J Gynaecol Obstet 2020 Apr 15. Epub 2020 Apr 15.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To evaluate differences in Doppler parameters and pregnancy outcomes, if any, and to determine the predictive accuracy of such indices, as well as the effects of low-dose aspirin (LDA) in unexplained recurrent pregnancy loss (URPL).

Methods: An observational study was conducted at Ren Ji Hospital, Shanghai, China, from May 2015 to December 2016. The endometrial thickness, and the pulsatility index (PI), resistive index (RI), and systolic-to-diastolic ratio (S/D) values of endometrial and uterine artery blood flow were collected. Read More

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http://dx.doi.org/10.1002/ijgo.13160DOI Listing

High incidence of diminished ovarian reserve in young unexplained recurrent pregnancy loss patients.

Gynecol Endocrinol 2020 Apr 11:1-3. Epub 2020 Apr 11.

Pacific Northwest Fertility and IVF Specialists, Seattle, WA, USA.

Recurrent pregnancy loss (RPL) is a clinically challenging scenario for patients and providers since an evidence-based approach to evaluation results in no explanation at least 50% of the time. The most common cause of first trimester clinical miscarriage is chromosome imbalance in the embryo or aneuploidy and the incidence of aneuploidy increases with age and diminished ovarian reserve (DOR). Currently, no professional societies recommend ovarian reserve testing in RPL patients, but some research shows a higher rate of DOR in miscarriage patients. Read More

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http://dx.doi.org/10.1080/09513590.2020.1750001DOI Listing

[Construction and validation of pregnancy risk prediction model for pregnant women with chronic kidney disease].

Zhonghua Fu Chan Ke Za Zhi 2020 Mar;55(3):172-176

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Meuitus, Beijing 100034, China.

To construct the pregnancy risk prediction model of chronic kidney disease (CKD) pregnant women by analyzing their renal function and pregnancy outcome in the first trimester. Totally 313 CKD women with 322 pregnancies who had deliveries in Peking University First Hospital from March 2009 to December 2018 were retrospectively analyzed. The history of kidney disease and renal function in the first trimester were collected, and the relationship between CKD and premature delivery, low birth weight infants, severe preeclampsia and fetal loss were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20190911-00482DOI Listing

Smith-Lemli-Opitz's Syndrome as a Possible Cause of Recurrent Pregnancy Loss: A Case Report.

AJP Rep 2020 Jan 31;10(1):e118-e120. Epub 2020 Mar 31.

Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Based on the known carrier frequency of Smith-Lemli-Opitz's syndrome (SLOS), the prevalence of this disease should be significantly higher than what is observed in the population. This may be due to a higher rate of pregnancy loss in affected embryos. Here, we present the case of a couple who underwent expanded carrier screening (ECS) after experiencing three first trimester pregnancy losses. Read More

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http://dx.doi.org/10.1055/s-0040-1705131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108949PMC
January 2020

Do Anti-Factor Xa Levels have any Impact on Pregnancy Outcome in Women with Previous Adverse Outcomes?

Z Geburtshilfe Neonatol 2020 Apr 1. Epub 2020 Apr 1.

Perinatology, Zekai Tahir Burak Health Practice Research Center, University of Health Sciences, Ankara, Turkey.

Objective: Low-molecular-weight heparin (LMWH) is used during pregnancy in women diagnosed with thrombophilia for prevention of thromboembolic events and prevention of recurrent pregnancy loss. Prophylactic dosing does not always achieve target anti-FXa levels of 0.2-0. Read More

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http://dx.doi.org/10.1055/a-1130-2017DOI Listing

Exposure to Endocrine-Disrupting Chemicals During Pregnancy Is Associated with Weight Change Through 1 Year Postpartum Among Women in the Early-Life Exposure in Mexico to Environmental Toxicants Project.

J Womens Health (Larchmt) 2020 Apr 1. Epub 2020 Apr 1.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.

The postpartum period may be a vulnerable life stage for a woman's cardiometabolic health. We examined associations of exposure to common endocrine-disrupting chemicals (EDCs) during pregnancy with weight from delivery through 1 year postpartum among 199 women in Mexico City. During each trimester of pregnancy, we collected a urine sample to assay bisphenol A (BPA), mono--butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-3-carboxypropyl phthalate (MCPP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), and monoethyl phthalate (MEP). Read More

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http://dx.doi.org/10.1089/jwh.2019.8078DOI Listing

Comparing prenatal screening experiences of Icelandic women who received false-positive and true-negative first-trimester combined screening results in Iceland in 2012-2016.

J Genet Couns 2020 Mar 21. Epub 2020 Mar 21.

Prenatal Diagnostic Unit, Women's and Children's Services, Landspitali University Hospital, Reykjavik, Iceland.

First-trimester combined screening (FTS) has been offered to all pregnant women in Iceland since 2003. Individuals with high-risk FTS results are offered an invasive test option with a ≤1% risk of fetal loss. This study gives insight into the prenatal screening and diagnosis experiences and preferences of 101 women who underwent FTS in Iceland in the years 2012-2016, comparing the experience of those who received false-positive FTS results to those who received true-negative results. Read More

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http://dx.doi.org/10.1002/jgc4.1269DOI Listing

Natural frozen embryo transfer with hCG booster leads to improved cycle outcomes: a retrospective cohort study.

J Assist Reprod Genet 2020 May 20;37(5):1177-1182. Epub 2020 Mar 20.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, 1305 York Ave, New York, NY, 10021, USA.

Purpose: To determine whether luteal support with intramuscular injection of human chorionic gonadotropin 1 day post-LH surge in natural cycle frozen embryo transfer (nFETs) increases ongoing pregnancy rates (OPR).

Methods: Retrospective cohort study of women who underwent natural cycle FET with transfer of a single day-5 or - 6 euploid blastocyst between January 2017 and December 2018 at an academic medical center were divided into two groups based on whether they received hCG 1 day post-LH surge. Patients with uterine factor infertility were excluded. Read More

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http://dx.doi.org/10.1007/s10815-020-01740-7DOI Listing

Non-immune fetal hydrops: etiology and outcomes according to gestational age at diagnosis.

Ultrasound Obstet Gynecol 2020 Mar 20. Epub 2020 Mar 20.

Fetal Medicine Unit, St George's Hospital, St George's University of London, UK.

Objectives: Fetal hydrops is associated with increased perinatal mortality and morbidity. The etiology and outcomes of fetal hydrops may differ according to the gestational age (GA) at diagnosis. The aim of this study was to evaluate the causes, evolution and outcomes of non-immune fetal hydrops (NIFH) according to the GA at diagnosis. Read More

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http://dx.doi.org/10.1002/uog.22019DOI Listing

Low frequency of flares during pregnancy and post-partum in stable lupus patients.

Arthritis Res Ther 2020 03 19;22(1):52. Epub 2020 Mar 19.

Hospital for Special Surgery, 535 E 70th Street, New York, NY, 10021, USA.

Background: Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the effect of pregnancy on SLE flares. This study aims to identify predictors of flares during and after pregnancy in SLE patients with inactive or stable disease activity during the first trimester and to characterize and estimate the frequency of post-partum flares in these patients. Read More

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http://dx.doi.org/10.1186/s13075-020-2139-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081564PMC

Pregnancy-preserving Laparoendoscopic Single-site Surgery for Gynecologic Disease: A Case Series.

J Minim Invasive Gynecol 2020 Feb 29. Epub 2020 Feb 29.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas (Drs. Xiao, Fu, Duan, Sunkara, and Guan); Department of Gynecology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China (Drs. Xiao and Wang).. Electronic address:

Study Objective: The study objective was to assess the feasibility of laparoendoscopic single-site surgery (LESS) for the management of nonobstetric, gynecologic disease processes in pregnant patients.

Design: A retrospective case series of 13 pregnant women aged 21 to 42 years who underwent LESS for various gynecologic pathology. If able to be contacted, the patients were followed up until the delivery of the fetus. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.02.009DOI Listing
February 2020

Prediction of pregnancy loss by early first trimester ultrasound characteristics.

Am J Obstet Gynecol 2020 Feb 25. Epub 2020 Feb 25.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. Electronic address:

Background: Pregnancy loss prediction based on routinely measured ultrasound characteristics is generally aimed toward distinguishing nonviability. Physicians also use ultrasound indicators for patient counseling, and in some cases to decide upon the frequency of follow-up sonograms. To improve clinical utility, allocation of cut-points should be based on clinical data for multiple sonographic characteristics, be specific to gestational week, and be determined by methods that optimize prediction. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.02.025DOI Listing
February 2020

Euploid miscarriage is associated with elevated serum C-reactive protein levels in infertile women: a pilot study.

Arch Gynecol Obstet 2020 Mar 27;301(3):831-836. Epub 2020 Feb 27.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.

Purpose: Increased serum C-protein (CRP) levels reduce fecundity in healthy eumenorrheic women with 1-2 pregnancy losses. Subclinical systemic inflammation may impede maternal immune tolerance toward the fetal semi-allograft, compromising implantation and early embryonic development. Some miscarriages with normal karyotypes could, therefore, be caused by inflammation. Read More

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http://dx.doi.org/10.1007/s00404-020-05461-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060953PMC

Cytomegalovirus infection during pregnancy: state of the science.

Am J Obstet Gynecol 2020 Feb 24. Epub 2020 Feb 24.

EA Fetus, Paris Descartes Université, Université de Paris, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malade, Maternité, Paris, France.

Cytomegalovirus is the most common congenital infection, affecting 0.5-2% of all live births and the main nongenetic cause of congenital sensorineural hearing loss and neurological damage. Congenital cytomegalovirus can follow maternal primary infection or nonprimary infection. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.02.018DOI Listing
February 2020

Chorionic villus sampling: 10 years of experience in a University referral center.

J Gynecol Obstet Hum Reprod 2020 May 19;49(5):101715. Epub 2020 Feb 19.

Prenatal Diagnosis Unit, Dr. Alfredo da Costa Maternity, Lisbon Central University Hospital Center, Lisbon, Portugal.

Objectives: The purpose of this study was to estimate our center-specific CVS-related miscarriage rate.

Methods: This is an observational retrospective study of women submitted to a CVS in our hospital, between January 1, 2007 and December 31, 2016. Maternal and pregnancy characteristics, procedure details, genetic results and pregnancy outcomes of all patients were collected. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101715DOI Listing

Selective growth of mosaic cells in chromosomal analysis of chorionic villi by conventional karyotyping.

Mol Cell Probes 2020 Jun 18;51:101532. Epub 2020 Feb 18.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, PR China.

The major cause of first-trimester pregnancy loss is chromosomal abnormality, which could be detected by many methods. Conventional karyotyping based on chorionic villi (CV) culture is frequently used but may have limitations due to culture failure and selective growth of cells. In this study, we aimed to investigate the degree of mosaicism present in villi by a combination of three different methods, namely conventional karyotyping following culture, multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH), with a view to exploring the incidence of selective growth of mosaic CV cells during the process of culture for conventional karyotyping. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101532DOI Listing

Prediction of Delivery Complications by First-Trimester Ultrasound Measurement of the Gestational Sac's Distance From a Previous Cesarean Section Scar.

J Ultrasound Med 2020 Feb 19. Epub 2020 Feb 19.

Department of Ultrasonography, West China Second University Hospital, Sichuan University, Chengdu, China.

Objectives: This study was designed to investigate the clinical relationship between labor complications in the second and third trimesters and the distance from the gestational sac to a previous cesarean section (CS) scar.

Methods: We conducted a retrospective review of the electronic medical records and included all 7- to 9-week transvaginal ultrasound examination reports from pregnancies with a history of a single cesarean delivery in our hospital between January 2015 and December 2017. Women were divided into 6 groups according to the distance of the gestational sac to the CS scar (groups A-F). Read More

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http://dx.doi.org/10.1002/jum.15245DOI Listing
February 2020

Baricitinib exposure during pregnancy in rheumatoid arthritis.

Ther Adv Musculoskelet Dis 2020 3;12:1759720X19899296. Epub 2020 Feb 3.

Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.

We here describe the case of a 43-year-old White woman who was diagnosed with rheumatoid arthritis treated with anti-tumour necrosis factor drugs that caused an adverse drug reaction. The objective of this study was to describe the outcome of a pregnancy under baricitinib, a JAK-inhibitor drug, in a woman affected by rheumatoid arthritis. Scant data are available about the safety of JAK inhibitors during pregnancy. Read More

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http://dx.doi.org/10.1177/1759720X19899296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997965PMC
February 2020

Peri-implantation urinary hormone monitoring distinguishes between types of first-trimester spontaneous pregnancy loss.

Paediatr Perinat Epidemiol 2020 Feb 13. Epub 2020 Feb 13.

Institute for Reproductive and Developmental Biology, Imperial College, London, UK.

Background: Lutenising hormone (LH) and human chorionic gonadotropin (hCG) hormone are useful biochemical markers to indicate ovulation and embryonic implantation, respectively. We explored "point-of-care" LH and hCG testing using a digital home-testing device in a cohort trying to conceive.

Objective: To determine conception and spontaneous pregnancy loss rates, and to assess whether trends in LH-hCG interval which are known to be associated with pregnancy viability could be identified with point-of-care testing. Read More

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http://dx.doi.org/10.1111/ppe.12613DOI Listing
February 2020

Imaging of Acute Pelvic Pain: Pregnant (Ectopic and First-trimester Viability Updated).

Radiol Clin North Am 2020 Mar;58(2):347-361

Department of Diagnostic Radiology, Oregon Health & Science University, L340, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.

Pelvic pain in the first trimester is nonspecific, with causes including pregnancy complications, pregnancy loss, and abnormal implantation, and symptom severity ranges from mild to catastrophic. Ultrasonography is the imaging modality of choice and essential to evaluate for the location of pregnancy, either intrauterine or not. If there is an intrauterine pregnancy, ultrasonography helps assess viability. Read More

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http://dx.doi.org/10.1016/j.rcl.2019.11.003DOI Listing

Managing venous thromboembolic risk in women undergoing spontaneous or induced early pregnancy loss: a consensus statement from the British Society of Haematology Obstetric Haematology Special Interest Group.

Br J Haematol 2020 Feb 5. Epub 2020 Feb 5.

Thrombosis & Haemophilia Centre, St Thomas' Hospital, London, UK.

The level of venous thrombosis risk in women who experience spontaneous or induced pregnancy loss has previously been uncertain. However, recent data indicate that the risk of venous thrombosis in women undergoing pregnancy termination in the first trimester is increased two-fold compared to non-pregnant women but reduced five-fold compared to women in the 6 weeks following a term birth. The termination procedure itself appears not to influence thrombosis risk. Read More

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http://dx.doi.org/10.1111/bjh.16496DOI Listing
February 2020

Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence.

Am J Obstet Gynecol 2020 Jan 29. Epub 2020 Jan 29.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, United Kingdom.

Progesterone is essential for the maintenance of pregnancy. Several small trials have suggested that progesterone supplementation may reduce the risk of miscarriage in women with recurrent or threatened miscarriage. Cochrane Reviews summarized the evidence and found that the trials were small with substantial methodologic weaknesses. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.12.006DOI Listing
January 2020
4.704 Impact Factor

Very Prolonged Anti-D: Confusion Surrounding Alloimmunization After Extra Rh Immunoglobulin: A Case Report.

J Obstet Gynaecol Can 2020 Jan 29. Epub 2020 Jan 29.

Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto ON; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON. Electronic address:

Background: Rh immunoglobulin (RhIg) is usually detectable a maximum of 12 to 14 weeks after administration. Positive antibodies beyond this time frame suggests alloimmunization.

Case: A woman had three pregnancies over a 6-month period, with two first-trimester losses. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.11.070DOI Listing
January 2020

Early pregnancy ultrasound measurements and prediction of first trimester pregnancy loss: A logistic model.

Sci Rep 2020 Jan 31;10(1):1545. Epub 2020 Jan 31.

University of Tennessee Health Science Center, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Memphis, Tennessee, USA.

Our objective was to prospectively validate the use of gestational sac (GS), yolk sac (YS) diameter, crown-rump length (CRL), and embryonal heart rate (HR) dimensions to identify early pregnancy loss. This was a prospective cohort study of first trimester pregnancies. GS and YS diameter, CRL, and HR measurements were serially obtained in singleton and twin pregnancies from 6 through 10 weeks' gestation. Read More

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http://dx.doi.org/10.1038/s41598-020-58114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994659PMC
January 2020

Detecting trisomy in products of conception from first-trimester spontaneous miscarriages by next-generation sequencing (NGS).

Medicine (Baltimore) 2020 Jan;99(5):e18731

First Affiliated Hospital of Kunming Medical University, Kunming.

Miscarriage is the spontaneous loss of a clinically established intrauterine pregnancy before the fetus has reached viability. In order to compare the performance of traditional G banding karyotyping with next-generation sequencing (NGS) for detecting common trisomies in products of conception (POC). Chromosome abnormalities were detected by high-resolution G banding karyotyping and NGS. Read More

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http://dx.doi.org/10.1097/MD.0000000000018731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004681PMC
January 2020
5.723 Impact Factor

Cytogenetic analysis of 3387 umbilical cord blood in pregnant women at high risk for chromosomal abnormalities.

Mol Cytogenet 2020 23;13. Epub 2020 Jan 23.

2Department of Reproductive Genetic Family, Hebei General Hospital, Shijiazhuang, 050051 P. R. China.

Background: Cordocentesis in our practice is most commonly indicated for rapid karyotyping in the second or third trimester and is regarded as the gold standard for foetal chromosomal aberration diagnosis in pregnancies at high risk for chromosomal abnormalities. In this study, we investigated 3387 umbilical cord blood samples for karyotyping from pregnant women who underwent cordocentesis and explored the pregnancy outcomes of foetal sex chromosome mosaicism and chromosomal polymorphism.

Results: Out of the 3387 samples, 182 abnormal karyotypes were detected. Read More

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http://dx.doi.org/10.1186/s13039-020-0469-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979326PMC
January 2020

The use of specialised preterm birth clinics for women at high risk of spontaneous preterm birth: a systematic review.

BMC Pregnancy Childbirth 2020 Jan 29;20(1):58. Epub 2020 Jan 29.

National Women's Health, Auckland City Hospital, Auckland, New Zealand.

Background: Specialised preterm birth clinics care for women at high risk of spontaneous preterm birth. This systematic review assesses current practice within preterm birth clinics globally.

Methods: A comprehensive search strategy was used to identify all studies on preterm birth clinics on the MEDLINE, Embase, PsycINFO, CENTRAL and CINAHL databases. Read More

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http://dx.doi.org/10.1186/s12884-020-2731-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990596PMC
January 2020

The optimal timing of immunotherapy may improve pregnancy outcome in women with unexplained recurrent pregnancy loss: A perspective follow-up study in northeastern China.

Am J Reprod Immunol 2020 Apr 7;83(4):e13225. Epub 2020 Feb 7.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Problem: To determine whether patients with unexplained recurrent pregnancy loss (URPL) can benefit from pre-conception immunotherapy or on the early phase of the first trimester.

Method Of Study: The prospective follow-up study which involved pre-conception patients diagnosed with URPL following rigorous etiology screening in the medical center of recurrent pregnancy loss. In this study, pre-conception immunotherapy included lymphocyte immunotherapy (pre-LIT). Read More

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http://dx.doi.org/10.1111/aji.13225DOI Listing

Anti-Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy.

Int J Gynaecol Obstet 2020 Apr 14;149(1):66-70. Epub 2020 Feb 14.

Department of Perinatology, Obstetrics and Gynecology, Polish Mother's Memorial Hospital Research Institute, Łódź, Poland.

Objective: To assess anti-Müllerian hormone (AMH) levels as a marker of early abortion in the first trimester among women younger than 35 years.

Methods: Prospective study of women aged 18-34 years with a spontaneous pregnancy at less than 12.6 gestational weeks in Łódź, Poland, between January 2017 and November 2018. Read More

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http://dx.doi.org/10.1002/ijgo.13104DOI Listing

The Severity of Post-abortion Stress in Spontaneous, Induced and Forensic Medical Center Permitted Abortion in Shiraz, Iran, in 2018.

Iran J Nurs Midwifery Res 2020 Jan-Feb;25(1):84-90. Epub 2019 Dec 27.

Department of Midwifery, Maternal -Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Abortion and loss of pregnancy in the first trimester may affect maternal mortality and morbidity. This study aimed to determine the severity of post-abortion stress in spontaneous abortion, induced abortion, and Forensic Medical Center (FMC) referral abortions immediately after abortion and after 1 month of follow-up in Shiraz, Iran, in 2018.

Materials And Methods: This cross-sectional study was conducted on 104 mothers selected through convenience sampling method in 2018. Read More

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http://dx.doi.org/10.4103/ijnmr.IJNMR_36_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952917PMC
December 2019

The effect of physiotherapy intervention on the load of the foot and low back pain in pregnancy.

Ceska Gynekol 2019 ;84(6):450-457

Objective: Pregnant women are at elevated risk for functional and structural changes in the movement system. Common problems are loss of foot arch height and low back pain which can have strong influence on the decrease in quality of life.

Aims: The aim of the study was to assess effect of physiotherapy intervention for preventing and treating changes in foot structure as well as low back pain during pregnancy. Read More

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January 2020

Outcome of selective intrauterine growth restriction in monochorionic twin pregnancies at 16, 20 or 30 weeks according to the new consensus definition.

Ultrasound Obstet Gynecol 2020 Jan 16. Epub 2020 Jan 16.

Department of Obstetrics and Gynaecology, University Hospitals Leuven; Department of Development and Regeneration, Biomedical Sciences, KULeuven, Belgium.

Objectives: Recently, new criteria have been proposed to define selective intrauterine growth restriction (sIUGR) in monochorionic pregnancies based on the Delphi procedure. We report the outcome of sIUGR diagnosed according to this new consensus definition: either an estimated fetal weight (EFW) of 1 twin <3 centile or 2 of the following: EFW or abdominal circumference of 1 twin <10 centile, EFW discordance ≥25% or umbilical artery pulsatility index of the smaller twin > 95 centile.

Methods: We performed a retrospective analysis of the outcome of sIUGR diagnosed at 16, 20 or 30 weeks in a cohort of monochorionic diamniotic twin pregnancies followed from the first trimester. Read More

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http://dx.doi.org/10.1002/uog.21975DOI Listing
January 2020