17 results match your criteria First Seizure Pediatric Perspective

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[Structural epilepsy or herpes simplex encephalitis relapse: diagnostic problems].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5):123-127

Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.

The article gives the clinical case of herpes simplex encephalitis relapse with the resistant seizures in a child. What we describe is a clinical approach towards the differential diagnostic of the seizures in structural epilepsy, which are resistant to anticonvulsants, or late herpes simplex encephalitis relapse. Good clinical perspective may be the indication of the intratecal synthesis of the IgG-specific antibodies to the herpes simplex type 1 and 2. Read More

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Health Care System Costs Associated With Surgery and Medical Therapy for Children With Drug-Resistant Epilepsy in Ontario.

Neurology 2022 03 15;98(12):e1204-e1215. Epub 2022 Feb 15.

From the Institute of Health Policy, Management and Evaluation (E.W., A.G., G.T., B.H.S.) and Leong Centre for Healthy Children (A.G.), University of Toronto; Diagnostic Imaging (E.W.), Division of Neurology (E.W., O.C.S.), Neurosciences and Mental Health (L.D., O.Y.), Division of Pediatric Medicine (A.G.), and Department of Neurosurgery (J.R.), Hospital for Sick Children; ICES (E.W., A.G., B.H.S.); Toronto Health Economics and Technology Assessment (THETA) Collaborative (G.T., B.H.S.), University Health Network; and Public Health Ontario (B.H.S.), Toronto, Ontario, Canada.

Background And Objectives: Improvement in seizure control after epilepsy surgery could lead to lower health care resource use and costs, but it is uncertain whether this could offset the high costs related to surgery. This study aimed to evaluate phase-specific and cumulative long-term health care costs of surgery compared to medical therapy in children with drug-resistant epilepsy from the health care payer perspective.

Methods: Children who were evaluated for epilepsy surgery and treated with surgery or medical therapy from 2003 to 2018 at the Hospital for Sick Children in Toronto were identified from chart review and linked to their health administrative databases in Ontario, Canada. Read More

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Increased expression of Rho-associated protein kinase 2 confers astroglial Stat3 pathway activation during epileptogenesis.

Neurosci Res 2022 Apr 2;177:25-37. Epub 2021 Nov 2.

Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Patients with TLE are prone to tolerance to antiepileptic drugs. Based on the perspective of molecular targets for drug resistance, it is necessary to explore effective drug resistant genes and signaling pathways for the treatment of TLE. We performed gene expression profiles in hippocampus of patients with drug-resistant TLE and identified ROCK2 as one of the 20 most significantly increased genes in hippocampus. Read More

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"The First Thousand Days" Define a Fetal/Neonatal Neurology Program.

Mark S Scher

Front Pediatr 2021 2;9:683138. Epub 2021 Aug 2.

Division of Pediatric Neurology, Department of Pediatrics, Fetal/Neonatal Neurology Program, Emeritus Scholar Tenured Full Professor in Pediatrics and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

Gene-environment interactions begin at conception to influence maternal/placental/fetal triads, neonates, and children with short- and long-term effects on brain development. Life-long developmental neuroplasticity more likely results during critical/sensitive periods of brain maturation over these first 1,000 days. A fetal/neonatal program (FNNP) applying this perspective better identifies trimester-specific mechanisms affecting the maternal/placental/fetal (MPF) triad, expressed as brain malformations and destructive lesions. Read More

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Network for Therapy in Rare Epilepsies (NETRE): Lessons From the Past 15 Years.

Front Neurol 2020 14;11:622510. Epub 2021 Jan 14.

Institute for Transition, Rehabilitation and Palliation, Paracelsus Medical University, Salzburg, Austria.

In 2005, twork for herapy in are pilepsies (NETRE)-was initiated in order to share treatment experiences among clinicians in patients with rare epilepsies. Here we describe the structure of the rapidly growing NETRE and summarize some of the findings of the last 15 years. NETRE is organized in distinct groups (currently >270). Read More

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January 2021

Functional and resting-state characterizations of a periventricular heterotopic nodule associated with epileptogenic activity.

Neurosurg Focus 2020 02;48(2):E10

Departments of1Neuroscience and.

The object of this study was to extensively characterize a region of periventricular nodular heterotopia (PVNH) in an epilepsy patient to reveal its possible neurocognitive functional role(s). The authors used 3-T MRI approaches to exhaustively characterize a single, right hemisphere heterotopion in a high-functioning adult male with medically responsive epilepsy, which had manifested during late adolescence. The heterotopion proved to be spectroscopically consistent with a cortical-like composition and was interconnected with nearby ipsilateral cortical fundi, as revealed by fiber tractography (diffusion-weighted imaging) and resting-state functional connectivity MRI (rsfMRI). Read More

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February 2020

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study).

Hum Vaccin Immunother 2019 5;15(2):496-502. Epub 2018 Oct 5.

p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.

Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Read More

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February 2020

Therapeutic hypothermia translates from ancient history in to practice.

Pediatr Res 2017 01 27;81(1-2):202-209. Epub 2016 Sep 27.

Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Acute postasphyxial encephalopathy around the time of birth remains a major cause of death and disability. The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited". In this review, a historical perspective is provided from the first reported use of therapeutic hypothermia for brain injuries in antiquity, to the present day. Read More

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January 2017

Cost-utility analysis of competing treatment strategies for drug-resistant epilepsy in children with Tuberous Sclerosis Complex.

Epilepsy Behav 2016 10 31;63:79-88. Epub 2016 Aug 31.

Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA.

Background: The management of drug-resistant epilepsy in children with Tuberous Sclerosis Complex (TSC) is challenging because of the multitude of treatment options, wide range of associated costs, and uncertainty of seizure outcomes. The most cost-effective approach for children whose epilepsy has failed to improve with first-line medical therapy is uncertain.

Methods: A review of MEDLINE from 1990 to 2015 was conducted. Read More

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October 2016

Role of glyoxalase I gene polymorphisms in late-onset epilepsy and drug-resistant epilepsy.

J Neurol Sci 2016 Apr 27;363:200-6. Epub 2016 Jan 27.

Institute of Neurology, Guangdong Medical University, Zhanjiang, Guangdong 524001, China. Electronic address:

Background: Recent studies indicate that increased expression of glyoxalase I (GLO1) could result in epileptic seizures; thus, this study further explored the association of GLO1 with epilepsy from the perspective of molecular genetics.

Material And Methods: GLO1 single nucleotide polymorphisms (SNPs; rs1130534, rs4746 and rs1049346) were investigated in cohort I (the initial samples: 249 cases and 289 controls). A replication study designed to confirm the positive findings in cohort I was performed in cohorts II (the additional samples: 130 cases and 191 controls) and I+II. Read More

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Long-term outcome and need of re-operation in gastro-esophageal reflux surgery in children.

Pediatr Surg Int 2016 Mar 28;32(3):277-83. Epub 2015 Dec 28.

DINOGMI, University of Genoa, Genoa, Italy.

Background: Fundoplication is considered a mainstay in the treatment of gastro-esophageal reflux. However, the literature reports significant recurrences and limited data on long-term outcome.

Aims: To evaluate our long-term outcomes of antireflux surgery in children and to assess the results of redo surgery. Read More

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Safety, Awareness, and Familiarity regarding Epilepsy in Teenage Years (SAFETY): understanding the adolescents' perspective about their disease.

Epilepsy Behav 2014 Dec 15;41:114-8. Epub 2014 Oct 15.

Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd., Detroit, MI 48201, USA. Electronic address:

Objective: The objective of this study was to evaluate the understanding of adolescent patients regarding epilepsy.

Methods: The SAFETY (Safety, Awareness, and Familiarity regarding Epilepsy in Teenage Years) questionnaire (content validity index: 0.96, Flesch readability score: 66. Read More

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December 2014

Epilepsy classification: a cycle of evolution and revolution.

Curr Opin Neurol 2013 Apr;26(2):163-7

Child and Adolescent Department, Pediatric Neurology, University Hospitals, Geneva, Switzerland.

Purpose Of Review: This review presents the new terms and concepts proposed by the International League Against Epilepsy (ILAE) Classification Commission in 2010 to describe seizures and epilepsies. This is the first major revision in 21 years and reflects the rapid evolution in our understanding of the epilepsies.

Recent Findings: The article places these changes in an historical perspective, summarizes elements of the lively debate that followed publication, presents refinements addressing those concerns and discusses issues that remain to be addressed. Read More

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Medical care costs of newly diagnosed children with structural-metabolic epilepsy: a one year prevalence-based approached.

Seizure 2012 Dec 29;21(10):764-9. Epub 2012 Aug 29.

College of Pharmacy, Al-Rashed University, Baghdad, Iraq.

Purpose: Aims of this study were to estimate the first-year medical care costs of newly diagnosed children with structural-metabolic epilepsy and to determine the cost-driving factors in the selected population.

Method: This was a prevalence-based retrospective chart review that included patients who attended a pediatric neurology clinic in a tertiary referral center in Malaysia. The total first-year medical care costs were estimated from the provider (i. Read More

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December 2012

Anatomic hemispherectomy: historical perspective.

World Neurosurg 2013 Sep-Oct;80(3-4):396-8. Epub 2012 Apr 3.

Division of Pediatric Neurosurgery, Rainbow Babies and Children's Hospital, The Neurological Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

The history of surgical treatment for hemispheric epilepsy is rich with colorful twists and turns. The authors trace the evolution of the surgical treatment of hemispheric epilepsy from radical anatomic resections to current less invasive disconnection procedures. Anatomic hemispherectomy (AH) was first described by Dandy in 1928 as a treatment for gliomas. Read More

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December 2013

Epilepsy in women: special considerations for adolescents.

Int Rev Neurobiol 2008 ;83:91-111

Department of Neurology and Pediatrics, Division of Pediatric Neurology, Pediatric Comprehensive Epilepsy Program, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Adolescence is a time of many changes. It is a time of growing independence, physical and emotional change, accompanied by social insecurity. Girls tend to enter puberty ahead of their male peers, growing and changing physically. Read More

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January 2009

Prenatal contributions to epilepsy: lessons from the bedside.

Mark S Scher

Epileptic Disord 2003 Jun;5(2):77-91

Case Western Reserve University, Ohio, USA.

While epilepsy can present at any age, this condition often occurs because of adverse events early in life. Pathogenetic mechanisms also cause deleterious consequences to the brain during prenatal life. For the epileptologist to fully appreciate developmental epileptogenesis, one must apply an ontogenetic approach (i. Read More

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