35,710 results match your criteria Fine-Needle Aspiration of Neck Masses


Aggressive fibromatosis of the parotid gland.

Ear Nose Throat J 2018 Dec;97(12):E28-E30

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Extra-abdominal fibromatosis (EAF) is a rare, locally aggressive tumor that originates in fascial structures. It accounts for less than 0.3% of all tumors diagnosed. Read More

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December 2018

Novel method of histopathological analysis after testicular sperm extraction in patients with nonobstructive and obstructive azoospermia.

Clin Exp Reprod Med 2018 Dec 30;45(4):170-176. Epub 2018 Nov 30.

Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Objective: To assess whether the "testicular pool" could be used for histological analysis and whether it gave more accurate information than the standard testicular biopsy.

Methods: Between January 2017 and March 2018, this single-center prospective study included 60 azoospermic men undergoing conventional bilateral testicular sperm extraction. Six samples were excised from each testicle and transferred to an embryologist. Read More

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December 2018

Utility of Preoperative Staging of Ipsilateral Axilla with Ultrasound and Guided Needle Aspiration in Early-Stage Breast Cancer-Current Indian Scenario.

Indian J Surg Oncol 2018 Dec 26;9(4):505-510. Epub 2018 Jul 26.

2Department of Radiodiagnosis, Cancer Institute (WIA), Chennai, India.

Clinical assessment of the axilla, especially in early-stage breast cancer, can have a high degree of inaccuracy with over-staging curtailing the use of sentinel node biopsy. Imaging of axilla, using ultrasound ± guided fine needle aspiration cytology (FNAC) can help in better staging. In this study, we aim to compare physical examination and ultrasound of axilla and FNAC and assess their accuracy in preoperative staging of axilla. Read More

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December 2018

What is your diagnosis? Fine-needle aspirate of an enlarged sternal lymph node in a cat.

Vet Clin Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Comparative, Diagnostic, & Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

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December 2018

Superior detection of metastatic cystic lymphadenopathy in patients with papillary thyroid cancer by utilization of thyroglobulin washout.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

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December 2018

Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study.

Int J Endocrinol 2018 4;2018:8387530. Epub 2018 Nov 4.

Ultrasound Unit, Department of Radiology, University of Sao Paulo Medical School, Hospital das Clínicas, 05403-000 São Paulo, SP, Brazil.

Introduction: A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT).

Objective: The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT.

Materials And Methods: Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Read More

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November 2018

Role of Immunohistochemistry in Fine Needle Aspiration and Core Needle Biopsy of Thyroid Nodules.

Clin Exp Otorhinolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.

Objectives: Immunohistochemistry (IHC) has been used for the diagnosis of indeterminate results in fine needle aspiration (FNA) of thyroid nodules. However, the role of IHC in core needle biopsy (CNB) is not clear and the efficacy of testing for molecular markers following CNB has not been evaluated. The aim of this study is to compare the role of IHC staining in CNB with that in FNA when examining thyroid nodules and to compare the sensitivity and usefulness of different molecular markers. Read More

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December 2018

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

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January 2019

Unrecognized and delayed to diagnose of adolescence tuberculosis case in a boarding school in West Java, Indonesia.

Int J Mycobacteriol 2018 Oct-Dec;7(4):387-389

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Adolescent is a high-risk population for developing tuberculosis (TB) disease, unfortunately adolescence TB remains to be neglected. Clinical manifestations of TB are usually chronic and nonspecific that could be mimicking other disease. Unrecognized TB disease will lead to misdiagnosis, delayed, and inappropriate management. Read More

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December 2018

Has the role of EUS in rectal cancer staging changed in the last decade?

Endosc Ultrasound 2018 Nov-Dec;7(6):366-370

University of Texas MD Anderson Cancer Center Houston, Houston, Texas, USA.

The need for effective diagnosis, staging, and treatment of rectal cancer cannot be overstated. Accurate staging of rectal cancer has wide-ranging implications, including therapeutic strategy and prognosis. A change in stage may lead to the need for preoperative neoadjuvant therapy to decrease the risk of recurrence. Read More

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December 2018

Aeromonas induced polyostotic osteomyelitis in a juvenile loggerhead sea turtle Caretta caretta.

Dis Aquat Organ 2018 Dec;132(1):79-84

Department of Veterinary Medicine and Animal Productions, University Federico II, 80137, Naples, Italy.

Bacterial bone infections have been occasionally reported in wild sea turtles. This study reports on a sub-adult Caretta caretta affected by Aeromonas hydrophila osteomyelitis, with extensive involvement of cranial and caudal flippers. The turtle was severely debilitated, had limited flipper mobility and showed signs of pain in reaction to manipulation. Read More

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December 2018

Gross visual inspection by endosonographers during endoscopic ultrasound-guided fine needle aspiration.

Pancreatology 2018 Dec 2. Epub 2018 Dec 2.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background/objectives: A clear criterion for terminating endoscopic ultrasound fine needle aspiration (EUS-FNA) without rapid on-site evaluation (ROSE) has not been established. However, a possible solution includes gross visual inspection (GVI) of the sample obtained with EUS-FNA. We performed a retrospective study to elucidate the efficacy of GVI for the diagnostic yield of EUS-FNA. Read More

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December 2018

The role of BRCA1-associated protein 1 in the diagnosis of malignant mesothelioma in effusion and fine-needle aspiration cytology.

Diagn Cytopathol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York.

Background: Malignant mesothelioma (MM) is a diagnostically challenging entity in cytology specimens due to the lack of architectural context and a cytomorphologic overlap between malignant and reactive mesothelial cells (RMCs). A diagnostic marker with excellent specificity is not currently available in clinical practice. The newly appreciated BRCA1-associated protein 1 (BAP1) antibody may help distinguish MM from RMC based on its immunohistochemical (IHC) staining pattern but its role in cytopathology is controversial. Read More

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December 2018
1 Read

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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December 2018

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Endocrine 2018 Dec 5. Epub 2018 Dec 5.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Read More

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December 2018
2 Reads

Thyroid malignancy among patients with thyroid nodules in the United Arab Emirates: a five-year retrospective tertiary Centre analysis.

Thyroid Res 2018 30;11:17. Epub 2018 Nov 30.

6Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.

Objectives: Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy. Read More

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November 2018

High-accuracy Detection of Preoperative Thyroid Nodules Using Combination of BRAF Mutation and TMPRSS4 mRNA Level.

Arch Med Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background: Papillary thyroid cancer (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid cancers. Though the fine needle aspiration biopsy (FNAB) represents as the golden standard for the diagnostics of thyroid nodules, there is a ∼25% risk of indeterminate cytological features. TMPRSS4 is a newly found transmembrane serine protease which was overexpressed in papillary thyroid cancer (PTC). Read More

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December 2018

Intraparotid Facial Nerve Schwannoma in a Nine-Year-Old Patient: Diagnosis, Classification, and Surgical Approach Stages.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology, The Ministry of Health Izmir Tepecik Training and Research Hospital, Izmir, Turkey.

Intraparotid facial nerve schwannoma (IFNS) is rarely observed in children compared with adults. Only a few cases have been reported in the literature. After radiological imaging and fine needle aspiration biopsy, an IFNS diagnosis may be skipped and confused with pleomorphic adenoma, which has a high prevalence among patients who have a mass in the parotid gland. Read More

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November 2018
1 Read

Mammary analogue secretory carcinoma of salivary gland diagnosed on submandibular gland cytology: A case report and review of literature.

Cytopathology 2018 Dec 1. Epub 2018 Dec 1.

Department of Pathology, University of Missouri at Kansas City, Truman Medical Center, Kansas City, Missouri, USA.

Mammary analogue secretory carcinoma (MASC) of the salivary glands morphologic and molecular similarities to secretory carcinoma of the breast(sc). (1) Here, we report a 46 year old female who presented with a right submandibular gland mass. Fine needle aspiration differential diagnosis included oncocytosis, oncocytoma, acinic cell carcinoma and MASC. Read More

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December 2018
1 Read

Cystic lymphangioma of the pancreas: a hard diagnostic challenge between pancreatic cystic lesions-review of recent literature.

Gland Surg 2018 Oct;7(5):487-492

Department of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Section of General Surgery, University of Messina, Messina, Italy.

Lymphangiomas are rare congenital benign tumors arising from the lymphatic system. The incidence of this disease in the pancreas is extremely rare, accounting for less than 1% of these tumors. Before introducing the review we reported a case of a 67-year-old woman with cystic lymphangioma of the pancreas. Read More

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October 2018
3 Reads

Current controversies and future directions in the diagnosis and management of differentiated thyroid cancers.

Gland Surg 2018 Oct;7(5):473-486

Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

Despite the development of novel diagnostic, surgical, and chemotherapeutic approaches to differentiated thyroid cancers (DTCs), the diagnosis and management of these tumors remains controversial. The most recent American Thyroid Association (ATA) guidelines, released in 2015, reflect a recent shift towards less aggressive management for patients with DTCs. However, many clinicians have expressed concern that more conservative management will put patients at risk for disease recurrence and metastasis. Read More

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October 2018
1 Read

Complete Routine Remote Digital Pathology Services.

J Pathol Inform 2018 29;9:36. Epub 2018 Oct 29.

Department of Pathology, Førde Central Hospital, Førde, Norway.

Background: Validation studies in digital pathology addressed so far diverse aspects of the routine work. We aimed to establish a complete remote digital pathology service.

Methods: Altogether 2295 routine cases (8640 slides) were reported in our studies on digital versus microscopic diagnostics, remote reporting, diagnostic time, fine-needle aspiration cytology (FNAC) clinics, frozen sections, and diagnostic sessions with residents. Read More

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October 2018
2 Reads

Reclassification of lesions in biopsies by fine-needle aspiration of pancreas and biliary tree using Papanicolaou classification.

J Gastrointest Oncol 2018 Oct;9(5):847-852

Department of Cytopathology, Hospital General de Mexico "Gerardo Liceaga", Mexico City, Mexico.

Background: Our aim was to evaluate the application of the classification of the Papanicolaou Cytopathology Society for the report of biopsies by fine-needle aspiration (FNA) of pancreas and bile duct.

Methods: The FNAs obtained consecutively during 1 year were analyzed. Descriptive statistics were performed and sensitivity, specificity, positive predictive value, negative predictive value, and cytohistological correlation were determined. Read More

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October 2018
1 Read

First case on fluorodeoxyglucose positron emission tomography/computerized tomography of a distant skip metastases to parotid node from esophageal adenocarcinoma.

World J Nucl Med 2018 Oct-Dec;17(4):302-304

Department of Nuclear Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

We are presenting the first case of a gastro-oesophageal junction adenocarcinoma with metastasis only to the intraparotid lymph node simulating Warthin's tumor. A 66-year-old man underwent an esophagogastroduodenoscopy that found circumferential ulcerated esophageal tumor beginning 40 cm from incisors resulting in stricture and two discrete erosions in the proximal third of esophagus. Biopsies from the stricture have demonstrated a poorly differentiated gastric adenocarcinoma. Read More

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December 2018
1 Read

Tumor growth rate of pancreatic serous cystadenomas: Endosonographic follow-up with volume measurement to predict cyst enlargement.

Pancreatology 2018 Nov 23. Epub 2018 Nov 23.

Gastroclinica WGO Training Center, Tibás, San José, Costa Rica.

Background: Serous cystadenomas are benign lesions of the pancreas. Usually they are diagnosed incidentally on cross-sectional imaging studies. Endosonography is a valuable tool in the diagnosis and follow-up of these cystic lesions. Read More

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November 2018
1 Read

Retroperitoneal Abscess Associated With a Migrating Grass Awn in a Cat: Treatment With Omentalization and Grass Awn Removal.

Top Companion Anim Med 2018 Dec 29;33(4):97-99. Epub 2018 Aug 29.

Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

An 18-month-old domestic short hair male castrated cat presented with a history of fever of unknown origin of 1-year duration. Abdominal ultrasound revealed a mixed echogenicity mass. Cytological examination of the fluid obtained through fine needle aspiration was consistent with a retroperitoneal abscess. Read More

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December 2018
1 Read

Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders.

Top Companion Anim Med 2018 Dec 8;33(4):105-108. Epub 2018 Sep 8.

Dipartimento di Medicina Veterinaria (DiMeV), Section of Surgery and Obstetrics, University of Bari Aldo Moro, Italy. Electronic address:

In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. Read More

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December 2018
1 Read

Correlation of Ultrasound Findings and Fine-Needle Aspiration Cytology for the Diagnosis of Axillary Lymph Node Metastasis in Patients with Breast Carcinoma.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Department of Cytology, Kuwait Cancer Control Center, Safat, Kuwait.

Objective: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. Read More

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December 2018
4 Reads

The Application of Ultrasound and Fine-Needle Aspiration in Low-Volume Lateral Lymph Nodes of Papillary Thyroid Carcinoma Patients.

Ultrasound Q 2018 Dec 3. Epub 2018 Dec 3.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

This research investigates the application of high-frequency ultrasound (US) examination and US-guided fine-needle aspiration (US-FNA) in diagnosing low-volume metastatic lateral lymph nodes (LLNs) from papillary thyroid carcinoma patients. This study reviewed the medical records of 996 LLNs from 858 patients with suspicious thyroid nodules or after thyroidectomy from January 2013 to January 2016. All patients took US-FNA. Read More

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December 2018
1 Read

Tuberculous neck lymphadenopathy: a diagnostic challenge.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Division of Otorhinolaryngology, University of Eastern Piedmont, Novara, Italy.

Tuberculosis (TB) continues to be a major health problem for the developing world and a a rise in the number of cases has been noted in the western hemisphere too. TB can affect most organs in the head and neck region, such as the lymph nodes, larynx, middle ear, oral cavity and pharynx. In particular, as for cervical tuberculosis lymphadenopathy, a predominant involvement of the posterior triangle, supraclavicular, and internal jugular group of nodes bilaterally can be observed. Read More

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December 2018
6 Reads

Transhepatic forceps biopsy combined with biliary drainage in obstructive jaundice: safety and accuracy.

Eur Radiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Interventional and Diagnostic Imaging, University Hospital of Caen, Avenue de la Côte de Nacre, 14033, Caen Cedex, France.

Purpose: This study was conducted in order to investigate the safety and accuracy of percutaneous transluminal forceps biopsy (PTFB) during percutaneous biliary drainage (PTBD) in patients with a suspicion of malignant biliary stricture.

Material And Methods: Fifty consecutive patients with obstructive jaundice underwent PTFB during PTBD. Biopsy specimens were obtained using 5. Read More

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December 2018
1 Read

The assessment of endosonographers in training.

World J Clin Cases 2018 Nov;6(14):735-744

Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg 41345, Sweden.

Endosonography (EUS) has an estimated long learning curve including the acquisition of both technical and cognitive skills. Trainees in EUS must learn to master intraprocedural steps such as echoendoscope handling and ultrasonographic imaging with the interpretation of normal anatomy and any pathology. In addition, there is a need to understand the periprocedural parts of the EUS-examination such as the indications and contraindications for EUS and potential adverse events that could occur post-EUS. Read More

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November 2018
2 Reads

Hypervascular lesions of the pancreas: Think before you act.

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, Division of Surgical Oncology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

Background: The "classic" CT appearance of pancreatic neuroendocrine tumors (PNETs) is a solid, hypervascular lesion; however, non-PNET diagnoses may appear similar. In addition, some PNETs have a "non-classic" appearance.

Methods: Demographic, imaging, endoscopic ultrasound-fine needle aspiration (EUS/FNA) results, and pathology data were analyzed for patients who underwent pancreatectomy for suspected or confirmed diagnosis of PNET from our institutional database. Read More

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November 2018

Assessment of diagnostic value of cytological examination in lung carcinoma in own material obtained by EBUS and EUS methods.

Pol J Pathol 2018 ;69(3):278-284

The aim of the study was the evaluation of the efficiency of cytological examination of the material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound bronchoscope-guided fine needle aspiration (EUSB-FNA) methods in the diagnosis of lung carcinoma. The usefulness was also assessed of the material obtained in that way for immunocytochemical and molecular tests in the diagnosis of non-small cell lung carcinoma. The material included cytological preparations obtained by EBUS and EUS methods. Read More

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January 2018

Management of Patients with renal mass lesions based on renal biopsy cytology results.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

Northwestern University, Chicago, IL. Electronic address:

The benefit of renal biopsy, especially in patients with a history of malignancy (HOM), has not been well-studied. We studied the clinical management of 339 renal masses following fine needle aspirate (FNA) and/or core needle biopsy (CNB) with touch preparation. 41% of patients had HOM, which did not increase the incidence of renal malignancy. Read More

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November 2018
2 Reads

Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift.

Diagn Cytopathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Lung carcinoma is one of the commonest causes of cancer related death. Fine-needle aspiration cytology (FNAC) is a well-established technique in the diagnosis of various malignant tumors. FNAC is now an important technique in classifying lung carcinomas and also detecting salient mutational changes in lung carcinomas. Read More

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November 2018
5 Reads

Metastatic clear cell renal carcinoma to the auricular region disguised as a vascular thrombus: Case report.

Diagn Cytopathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, AC Camargo Cancer Center, São Paulo, Brazil.

In about 25-30% of patients with primary renal cell carcinoma, metastasis is not uncommon and usually does not give rise to difficulties in diagnosis. However, its presentation as a subcutaneous mass following an elapse of several years after the initial diagnosis is not only uncommon but may be also mistaken for a thrombus in imaging studies due to its common high vascularization. We present here a case of a 70-year-old woman with an oncologic history of renal cell carcinoma who noticed after five years a mass in the auricular region radiologically suggestive of a vascular thrombus. Read More

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November 2018

Thyroid nodule size calculated using ultrasound and gross pathology as predictors of cancer: A 23-year retrospective study.

Diagn Cytopathol 2018 Nov 29. Epub 2018 Nov 29.

The Department and Key Laboratory of Endocrinology and Metabolism, PLA General Hospital, Beijing, People's Republic of China.

Background: Thyroid nodules are very common. Ultrasound (US) and fine needle aspiration (FNA) are both integral in cancer screening. This study investigated the concordance between thyroid nodule sizes measured by US and gross pathologic examination and their relationship with malignancy. Read More

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November 2018
3 Reads

Cytodiagnosis of Rosai-Dorfman disease masquerading as lymphoma: A case report with brief review of literature.

J Lab Physicians 2018 Oct-Dec;10(4):460-463

Department of Pathology, PGIMER, Dr. RML Hospital, New Delhi, India.

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a self-limiting, benign histiocytic disorder. We report a case of RDD mimicking lymphoma clinically and cytologically in a 3-year-old male child. The present case highlights the importance of cytology in the diagnosis of RDD along with cytological features of other differential diagnoses. Read More

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December 2018
1 Read

Malignant melanoma of conjunctiva: Diagnosis on fine-needle aspiration cytology.

J Lab Physicians 2018 Oct-Dec;10(4):453-456

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Malignant melanoma of conjunctiva is an uncommon malignancy. The diagnosis is suspected clinically and confirmed on pathological examination. We present a case of a 63-year-old female with previous history of pigmented lesion in the right eye and subsequently diagnosed as malignant melanoma of right conjunctiva and cornea on fine-needle aspiration cytology and histopathology. Read More

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December 2018

Immunocytochemistry using Liquid-based Cytology: A Tool in Hormone Receptor Analysis of Breast Cancer.

J Cytol 2018 Oct-Dec;35(4):260-264

Department of Pathology, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha, India.

Context: Efficacy of immunocytochemistry (ICC) in determining molecular biomarkers like estrogen receptor (ER), progesterone receptors (PRs), and human epidermal growth factor receptor-2 (HER2).

Aims: To evaluate biomarkers using ICC in breast cancer as per American Society of Clinical Oncology/College of American Pathology (ASCO/CAP) guidelines.

Settings And Design: The study was conducted over a period of 2 years from September 2012 to August 2014 and is the first such study in eastern India. Read More

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December 2018
2 Reads

Diagnostic Value of S100p, IMP3, Maspin, and pVHL in the Differantial Diagnosis of Pancreatic Ductal Adenocarcinoma and Normal/chronic Pancreatitis in Fine Needle Aspiration Biopsy.

J Cytol 2018 Oct-Dec;35(4):247-251

Division of Cytopathology, Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey.

Introduction: Differentiation between pancreatic ductal adenocarcinoma (PDAC) from benign mimickers is a well-known problem in cytological materials. Recent studies incorporated biological markers into this question and some studies showed that expression of S100P, IMP3, and maspin as well as nonexpression of von Hippel-Lindau gene product (pVHL) were significantly correlated with PDAC. In this study, we aimed to investigate diagnostic value of maspin, IMP3, S100P, and pVHL immunostaining in fine needle aspiration biopsies (FNABs) of pancreatic lesions. Read More

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December 2018
2 Reads

Utility of FNAC in Dermatological Manifestations of Metastatic Cancer with the Review of the Literature.

J Cytol 2018 Oct-Dec;35(4):237-241

Department of Surgery, Maulana Azad Medical College, New Delhi, India.

Objectives: Cutaneous metastasis (CM) though rare, indicates a terminal event in any malignancy and has a grave outcome. The present study reiterates the role of fine needle aspiration cytology (FNAC) in the diagnosis of metastatic cutaneous nodules.

Materials And Methods: From 2015 to 2017, the department received 22,000 cases for FNAC. Read More

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December 2018

Role of Rapid On-site Evaluation in CT-guided Fine Needle Aspiration Cytology of Lung Nodules.

J Cytol 2018 Oct-Dec;35(4):229-232

Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Objective: To prospectively investigate the value of rapid on-site evaluation (ROSE) in transthoracic fine needle aspiration cytology (FNAC) of patients with pulmonary nodules. Computed tomography (CT)-guided FNA is commonly employed for the diagnosis of lung lesions and the most common reason for not being able to provide a diagnosis in FNA is inadequacy of samples.

Materials And Methods: This was a prospective study conducted in the departments of pathology and radiology of our cancer centre. Read More

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December 2018
1 Read

Evaluation of Estrogen and Progesterone Receptors and Her-2 Expression with Grading in the Fine-needle Aspirates of Patients with Breast Carcinoma.

J Cytol 2018 Oct-Dec;35(4):223-228

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: There has been a limited literature with regards to comparison between the pre-operative hormonal/Her-2 neu assessment by immunostaining on fine-needle aspiration (FNA) versus core needle biopsies (CNBs) and their correlation with grading of breast carcinoma.

Materials And Methods: Two hundred fifty FNAs and 201 CNBs from 252 patients with breast carcinoma were subjected immunocytochemical/histochemical (ICC/IHC) staining along with the grading by the Robinson cytologic and modified Scarff-Bloom-Richardson scoring systems, respectively. Depending on the material adequacy, IHC was also performed on cell blocks. Read More

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December 2018

Cytological Scoring of Breast Lesions and Comparison with Histopathological Findings.

J Cytol 2018 Oct-Dec;35(4):217-222

Department of Cytology and Radiology, Pushpagiri Institute of Medical Sciences, Tiruvalla, Kerala, India.

Context: Cytological assessment using various morphological parameters helps segregate breast lesions in fine-needle aspiration cytology (FNAC) into different categories. The prognosis and the line of management of each category differ accordingly.

Aims: This study aims at assessing the validity of Modified Masood's Scoring Index (MMSI) by the evaluation of cytomorphological features of various breast lesions compared with histopathological findings. Read More

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December 2018
2 Reads

Cytopathology of Pulmonary Lesions: A Tertiary Care Center Experience.

J Cytol 2018 Oct-Dec;35(4):212-216

Department of Pathology, SGRRIM and HS, Dehradun, Uttarakhand, India.

Background: Cytological evaluation of specimens from respiratory tract is the initial investigation in patients suspected to have pulmonary diseases. The various cytological specimens submitted for analysis include bronchoalveolar lavage, bronchial wash, brush smears, transbronchial needle aspiration, guided fine needle aspiration cytology (FNAC) smears and pleural fluid. Present study was undertaken to study the spectrum of lesions diagnosed by cytomorphological analysis of various cytological specimens. Read More

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December 2018
1 Read

Cytomorphological Differences between Liquid-Based Cytology and Conventional Smears in Fine-Needle Aspirates of Thyroid Lesions.

J Cytol 2018 Oct-Dec;35(4):208-211

Department of Surgery, Lady Hardinge Medical College, New Delhi, India.

Background: Liquid-based cytology (LBC) is becoming an independent processing modality for cytology specimens. Decreased obscuration, single-slide examination, lesser screening time, and potential application of ancillary techniques are the various advantages it offers.

Aim: To study and compare the cytological features of fine-needle aspirates from thyroid swellings on LBC with conventional smears (CS). Read More

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December 2018