Search our Database of Scientific Publications and Authors

I’m looking for a

    16108 results match your criteria Filariasis

    1 OF 323

    Use of Antibody Tools to Provide Serologic Evidence of Elimination of Lymphatic Filariasis in The Gambia.
    Am J Trop Med Hyg 2017 Nov 20. Epub 2017 Nov 20.
    Task Force for Global Health, Decatur, Georgia.
    A current need in the global effort to eliminate lymphatic filariasis (LF) is the availability of reliable diagnostic tools that can be used to guide programmatic decisions, especially decisions made in the final stages of the program. This study conducted in The Gambia aimed to assess antifilarial antibody levels among populations living in historically highly LF-endemic areas and to evaluate the use of serologic tools to confirm the interruption of LF transmission. A total of 2,612 dried blood spots (DBSs) collected from individuals aged 1 year and above from 15 villages were tested for antibodies to Wb123 by enzyme-linked immunosorbent assay (ELISA). Read More

    Newly Arrived African Migrants to Spain: Epidemiology and Burden Disease.
    Am J Trop Med Hyg 2017 Nov 20. Epub 2017 Nov 20.
    RICET (Red de Investigación Cooperativa en Enfermedades Tropicales).
    The aim of this study is to describe the epidemiological profile, clinical characteristics, and microbiological findings in African immigrants newly arrived to Spain attended at a specialized reference unit from October 2004 to February 2017. A common protocol for the screening of imported and cosmopolitan diseases was designed to evaluate patients with ≤ 12 months of stay in Spain. A total of 523 patients were included in the study, 488 (93. Read More

    Changes in cytokine, filarial antigen, and DNA levels associated with adverse events following treatment of lymphatic filariasis.
    J Infect Dis 2017 Nov 15. Epub 2017 Nov 15.
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
    Background: Mild to moderate adverse events (AEs) are common after treatment of lymphatic filariasis (LF) and pose a major challenge for the global LF elimination program. We studied changes in cytokine levels and filarial worm components in plasma of subjects with and without AEs following treatment of LF.

    Methods: Participants (N=24) were hospitalized and monitored for AEs following treatment. Read More

    Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity.
    Am J Trop Med Hyg 2017 Oct 30. Epub 2017 Oct 30.
    Institute of Parasitology, McGill University, Montreal, Quebec, Canada.
    Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration. Studies in animal models and one trial in patients infected with Onchocerca volvulus revealed that FLBZ elicits minimal effects on microfilariae (mf). Severe complications after ivermectin (IVM) treatment of patients with high Loa loa microfilaraemia are of great concern. Read More

    Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes.
    Am J Trop Med Hyg 2017 Oct 30. Epub 2017 Oct 30.
    AU-KBC Research Centre, MIT Campus of Anna University, Chennai, India.
    Recent epidemiological studies have documented an inverse relationship between the decreasing prevalence of helminth infections and the increasing prevalence of metabolic diseases ("metabolic hygiene hypothesis"). Chronic inflammation leading to insulin resistance (IR) has now been identified as a major etiological factor for a variety of metabolic diseases other than obesity and Type-2 diabetes (metainflammation). One way by which helminth infections such as filariasis can modulate IR is by inducing a chronic, nonspecific, low-grade, immune suppression mediated by modified T-helper 2 (Th2) response (induction of both Th2 and regulatory T cells) which can in turn suppress the proinflammatory responses and promote insulin sensitivity (IS). Read More

    Use of a Novel Portable Three-Dimensional Scanner to Measure Limb Volume and Circumference in Patients with Filarial Lymphedema.
    Am J Trop Med Hyg 2017 Oct 16. Epub 2017 Oct 16.
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
    The World Health Organization's Global Program to Eliminate Lymphatic Filariasis (LF) has reduced LF transmission worldwide, but millions remain affected by filarial lymphedema. Tools for clinically monitoring lymphedema in developing nations are limited. We tested a novel, portable, infrared three-dimensional (3D) scanner against water displacement (WD) and tape measurement of limb circumference (TMLC) among patients with filarial leg lymphedema in Galle, Sri Lanka. Read More

    Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.
    PLoS One 2017 15;12(11):e0188138. Epub 2017 Nov 15.
    Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.
    Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive. Read More

    Patent landscape of neglected tropical diseases: an analysis of worldwide patent families.
    Global Health 2017 Nov 14;13(1):82. Epub 2017 Nov 14.
    Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
    Background: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. Read More

    Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti.
    Hum Genomics 2017 Nov 9;11(1):26. Epub 2017 Nov 9.
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
    Background: Lymphedema (LE) is a chronic clinical manifestation of filarial nematode infections characterized by lymphatic dysfunction and subsequent accumulation of protein-rich fluid in the interstitial space-lymphatic filariasis. A number of studies have identified single nucleotide polymorphisms (SNPs) associated with primary and secondary LE. To assess SNPs associated with LE caused by lymphatic filariasis, a cross-sectional study of unrelated Ghanaian volunteers was designed to genotype SNPs in 285 LE patients as cases and 682 infected patients without pathology as controls. Read More

    A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas.
    N Engl J Med 2017 Nov 8;377(21):2044-2052. Epub 2017 Nov 8.
    From the Center for Research on Filariasis and other Tropical Diseases (J.K., H.C.N.-D., R.G.-K., G.-R.N., P.N., J.B.T.-M.) and the Faculty of Medicine and Biomedical Sciences, University of Yaounde I (J.K.), Yaounde, and the Faculty of Health Sciences, Department of Microbiology and Parasitology, University of Buea, and Research Foundation for Tropical Diseases and Environment (REFOTDE), Buea (S.W.) - all in Cameroon; Institut de Recherche pour le Développement Unité Mixte Internationale 233-INSERM Unité 1175, Montpellier University, Montpellier, France (S.D.P., C.B.C., M.B.); the Department of Bioengineering and the Biophysics Program, University of California, Berkeley, Berkeley (M.H.B., M.V.D., D.A.F.); the Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing (C.D.M.); the Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (W.A.S.); the Chan Zuckerberg Biohub, San Francisco (D.A.F.); and the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD (A.D.K., T.B.N.).
    Background Implementation of an ivermectin-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis has been delayed in Central Africa because of the occurrence of serious adverse events, including death, in persons with high levels of circulating Loa loa microfilariae. The LoaScope, a field-friendly diagnostic tool to quantify L. loa microfilariae in peripheral blood, enables rapid, point-of-care identification of persons at risk for serious adverse events. Read More

    Phylogenetic study based on 28S rRNA gene sequencing of Wuchereria bancrofti isolated from the filaria endemic areas of Bankura district, West Bengal, India.
    J Parasit Dis 2017 Dec 11;41(4):981-986. Epub 2017 May 11.
    Department of Nutrition, A.K.P.C Mahavidyalaya, Bengai, Hooghly, India.
    Lymphatic filariasis is one of the major public health concern in India, and Bankura district of West Bengal is one of the main filaria prone area of the country. Wuchereria bancrofti is the causative organism and Culex quinquefasciatus is the main vector of lymphatic filariasis in India. In the present study, infection and infectivity rate of filarial vector C. Read More

    Draft genome sequence of the Wolbachia endosymbiont of WuchereriabancroftiwWb.
    Pathog Dis 2017 Nov 1. Epub 2017 Nov 1.
    Institute for Genome Sciences, University of Maryland, Baltimore, MD, 21201, USA.
    The draft genome assembly of the Wolbachia endosymbiont of Wuchereria bancrofti (wWb) genome consists of 1,060,850 bp in 100 contigs and contains 961 ORFs, with a single copy of the 5S rRNA, 16S rRNA, and 23S rRNA and each of the 34 tRNA genes. Phylogenetic core genome analyses show wWb to cluster with other strains in supergroup D of the Wolbachia phylogeny, while being most closely related to the Wolbachia endosymbiont of Brugia malayi strain TRS (wBm). The wWb and wBm genomes share 779 orthologous clusters with wWb having 101 unclustered genes and wBm having 23 unclustered genes. Read More

    Chemical composition and insecticidal activity of the essential oil from Helichrysum faradifani endemic to Madagascar.
    Nat Prod Res 2017 Nov 3:1-9. Epub 2017 Nov 3.
    f School of Pharmacy , University of Camerino , Camerino , Italy.
    Helichrysum faradifani (Asteraceae) is a perennial shrub growing in rocky and sandy places of Madagascar. The plant is used in the Malagasy traditional medicine as a wound-healing agent, disinfectant and for the treatment of syphilis, diarrhea, cough and headache. In the present work, we analysed the chemical composition of the essential oil distilled from the aerial parts of H. Read More

    Neglected tropical diseases in Brazilian children and adolescents: data analysis from 2009 to 2013.
    Infect Dis Poverty 2017 Nov 3;6(1):154. Epub 2017 Nov 3.
    Laboratory of Pathology and Bio-Intervention, Gonçalo Moniz Institute (Fiocruz-BA), Salvador, Bahia, Brazil.
    Background: Neglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infections require mandatory notification: acute Chagas disease, leishmaniasis, malaria, and schistosomiasis. Data on the behaviour of these NTDs in the young population are currently limited. Read More

    Gold nanoparticles - against parasites and insect vectors.
    Acta Trop 2017 Oct 29;178:73-80. Epub 2017 Oct 29.
    Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy; The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy. Electronic address:
    Nanomaterials are currently considered for many biological, biomedical and environmental purposes, due to their outstanding physical and chemical properties. The synthesis of gold nanoparticles (Au NPs) is of high interest for research in parasitology and entomology, since these nanomaterials showed promising applications, ranging from detection techniques to drug development, against a rather wide range of parasites of public health relevance, as well as on insect vectors. Here, I reviewed current knowledge about the bioactivity of Au NPs on selected insect species of public health relevance, including major mosquito vectors, such as Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Read More

    Reassessment of areas with persistent Lymphatic Filariasis nine years after cessation of mass drug administration in Sri Lanka.
    PLoS Negl Trop Dis 2017 Oct 30;11(10):e0006066. Epub 2017 Oct 30.
    Washington University School of Medicine, St. Louis, MO, United States of America.
    Background: Sri Lanka was one of the first countries to initiate a lymphatic filariasis (LF) elimination program based on WHO guidelines. The Anti-Filariasis Campaign provided 5 annual rounds of mass drug administration (MDA) with diethylcarbamazine plus albendazole in all 8 endemic districts from 2002-2006. Microfilaremia (Mf) prevalences have been consistently <1% in all sentinel and spot-check sites since 2006, and all evaluation units passed school-based transmission assessment surveys (TAS) in 2013. Read More

    Exploration of antifilarial activity of gold nanoparticle against human and bovine filarial parasites: A nanomedicinal mechanistic approach.
    Colloids Surf B Biointerfaces 2017 Oct 20;161:236-243. Epub 2017 Oct 20.
    Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, 731235, India. Electronic address:
    The present work seeks to explore the antifilarial activity of biopolymer functionalized gold nanoparticles (AuNPs) against human filarial parasite (Wuchereria bancrofti) through Nrf2 signaling for the first time. A natural polymer, chitosan is used along with Terminalia chebula extract to synthesize AuNPs following the principles of green chemistry. The probable mode of action of AuNPs as filaricidal agent has been investigated in detail using model filarial parasite, Setaria cervi (bovine parasite). Read More

    Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.
    Proc Natl Acad Sci U S A 2017 Nov 23;114(45):E9712-E9721. Epub 2017 Oct 23.
    Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
    Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-day period. Here we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the filarial endosymbiont Wolbachia, a proven macrofilaricide target, which reduces treatment from several weeks to 7 days in preclinical models. ABZ had negligible effects on Wolbachia but synergized with minocycline or rifampicin (RIF) to deplete symbionts, block embryogenesis, and stop microfilariae production. Read More

    Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review.
    Lancet Infect Dis 2017 Oct 23. Epub 2017 Oct 23.
    Institute of Public Health, University of Heidelberg, Heidelberg, Germany; Special Programme for Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland. Electronic address:
    In light of the recent Zika virus outbreak, vector control has received renewed interest. However, which interventions are efficacious and community effective and how to best deliver them remains unclear. Following PRISMA guidelines, we did a systematic review to assess evidence for applied vector control interventions providing protection against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis at the household level. Read More

    Mansonella ozzardi and its vectors in the New World: an update with emphasis on the current situation in Haiti.
    J Helminthol 2017 Oct 25:1-7. Epub 2017 Oct 25.
    Department of Infectious and Communicable Diseases,Quisqueya University,Port-au-Prince,Haïti.
    Mansonella ozzardi (Nematoda: Onchocercidae) is a little studied filarial nematode. This human parasite, transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and blackflies (genus Simulium), is endemic to the Neotropical regions of the New World. With a patchy geographical distribution from southern Mexico to north-western Argentina, human infection with M. Read More

    Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo.
    Pathog Glob Health 2017 Oct 25;111(7):388-394. Epub 2017 Oct 25.
    b Faculty of Medicine, Department of Anesthesiology , University of Malaya , Kuala Lumpur , Malaysia.
    Lymphatic filariasis (LF) is a vector borne disease caused by parasitic worms such as Wuchereria bancrofti, Brugia malayi and B. timori, which are transmitted by mosquitoes. Current therapeutics to treat LF are mainly microfilarcidal, and lack activity against adult worms. Read More

    Translating Research into Reality: Elimination of Lymphatic Filariasis from Haiti.
    Am J Trop Med Hyg 2017 Oct;97(4_Suppl):71-75
    University of Notre Dame, Notre Dame, Indiana.
    Research provides the essential foundation of disease elimination programs, including the global program to eliminate lymphatic filariasis (GPELF). The development and validation of new diagnostic tools and intervention strategies, critical steps in the evolution of GPELF, required a global effort. Lymphatic filariasis research in Haiti involved many partners and was directly linked to the development of the national elimination program and to the success achieved to date. Read More

    Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.
    J Physiol 2017 Oct 23. Epub 2017 Oct 23.
    Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585, Japan.
    Ivermectin (IVM) is an antiparasitic drug that is used worldwide and rescues hundreds of millions of people from onchocerciasis and lymphatic filariasis. It was discovered by Satoshi Ōmura and William C. Campbell, to whom the 2015 Nobel Prize in Physiology or Medicine was awarded. Read More

    Hydrophilic nanosilica as a new larvicidal and molluscicidal agent for controlling of major infectious diseases in Egypt.
    Vet World 2017 Sep 11;10(9):1046-1051. Epub 2017 Sep 11.
    Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box 12211, Egypt.
    Aim: This research was conducted to evaluate the molluscicidal and mosquitocidal efficacy of silica nanoparticles in the eradication of the larvae and pupa of malaria and filariasis vector as well as vectors of rift-valley fever virus (Culex pipiens); Schistosoma mansoni vector and Biomphlaria alexandrina (snail and egg masses).

    Materials And Methods: Hydrophilic nanosilica particles (NSPs) were characterized using transmission electron microscope during the preliminary part of the study; the stages were exposed to upgrade concentrations of NSP from 50 to 1200 ppm each for 24-36 h exposure time. The highly effective concentrations were re-evaluated at lower exposure time as 3, 6, and 12 h. Read More

    Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment.
    PLoS Negl Trop Dis 2017 Oct 23;11(10):e0005631. Epub 2017 Oct 23.
    Tropical Projects, Hitchin, United Kingdom.
    Background: Once interruption of transmission of lymphatic filariasis is achieved, morbidity prevention and management becomes more important. A study in Brugia malayi filariasis from India has shown sub-clinical lymphatic pathology with potential reversibility. We studied a Wuchereria bancrofti infected population, the major contributor to LF globally. Read More

    Field evaluation of a novel molluscicide (niclosamidate) against Oncomelania hupensis, intermediate host of Schistosoma japonicum.
    Parasitol Res 2017 Dec 18;116(12):3423-3427. Epub 2017 Oct 18.
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, 207 Ruijin er Road, Huangpu District, Shanghai, 200025, China.
    The molluscicidal activity of a novel molluscicide (niclosamidate) was evaluated in field trials against Oncomelania hupensis, the intermediate host of Schistosoma japonicum. The environmental safety of niclosamidate for local fishes was also studied under field conditions. The results showed that, at the dosages of 8. Read More

    Familial aggregation and heritability of Loa loa microfilaremia.
    Clin Infect Dis 2017 Oct 10. Epub 2017 Oct 10.
    IRD UMI 233-INSERM U1175-Montpellier University, Montpellier, France.
    Background: For a given prevalence of Loa loa microfilaremia, the proportion of people with high densities varies significantly between communities. We hypothesized that this variation is related to the existence of familial clusters of hypermicrofilaremic individuals that would be the consequence of a genetic predisposition to present high L. loa microfilarial densities. Read More

    Toxicity studies of nanofabricated palladium against filariasis and malaria vectors.
    Environ Sci Pollut Res Int 2017 Oct 15. Epub 2017 Oct 15.
    Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Vellore, Tamil Nadu, 632006, India.
    The present study was carried out to establish the biofabrication of palladium nanoparticles (PdNPs) using the plant leaf extract of Tinospora cordifolia Miers and its toxicity studies on the larvae of filariasis vector, Culex quinquefasciatus Say and malaria vector, Anopheles subpictus Grassi. The biofabricated PdNPs were characterized by using UV-visible spectrum, FTIR, XRD, FESEM, EDX and HRTEM. HRTEM confirmed the PdNPs were slightly agglomerated and spherical in shape and the average size was 16 nm. Read More

    Bioefficacy of Some Egyptian Aromatic Plants on Culex pipiens (Diptera: Culicidae) Adults and Larvae.
    J Arthropod Borne Dis 2017 Mar 14;11(1):147-155. Epub 2017 Mar 14.
    Parasitology Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
    Background: Protecting the environment from chemical hazards of synthetic insecticides along with offering of new breeding areas for vectors by urbanization indicate the trial of natural insecticides.

    Methods: The acetone extracts of Anethum graveolens, Ocimum basilicum and Thymus vulgaris were tested for their insecticidal effect on Culex pipiens adults and larvae in different concentrations depending on the technique used.

    Results: The extracts were significantly effective in all models used with basil being the best in all tested three techniques (LC50= 0. Read More

    The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness.
    Clin Infect Dis 2017 Jul 19. Epub 2017 Jul 19.
    UMI233-TransVIHMI, Institut de Recherche pour le Développement (IRD), INSERM U1175, University of Montpellier, Montpellier, France.
    Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020/2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca volvulus. A single ivermectin (standard) dose clears the skin-dwelling microfilarial progeny of adult worms (macrofilariae) and temporarily impedes the release of such progeny by female macrofilariae, but a macrofilaricidal effect has been deemed minimal. Read More

    Is mass drug administration against lymphatic filariasis required in urban settings? The experience in Kano, Nigeria.
    PLoS Negl Trop Dis 2017 Oct 11;11(10):e0006004. Epub 2017 Oct 11.
    Centre for Neglected Tropical Diseases and Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
    Background: The Global Programme to Eliminate Lymphatic Filariasis (GPELF), launched in 2000, has the target of eliminating the disease as a public health problem by the year 2020. The strategy adopted is mass drug administration (MDA) to all eligible individuals in endemic communities and the implementation of measures to reduce the morbidity of those suffering from chronic disease. Success has been recorded in many rural endemic communities in which elimination efforts have centered. Read More

    Prevalence of Clinical and Subclinical Plasmodium falciparum and Plasmodium vivax Malaria in Two Remote Rural Communities on the Myanmar-China Border.
    Am J Trop Med Hyg 2017 Nov 10;97(5):1524-1531. Epub 2017 Oct 10.
    Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
    Malaria infections may be symptomatic, leading to treatment, or "asymptomatic," typically detected through active surveillance, and not leading to treatment. Malaria elimination may require purging both types of infection. Using detection methods with different sensitivities, we conducted a cross-sectional study in two rural communities located along the border between China's Yunnan Province and Myanmar's Shan and Kachin States, to estimate the prevalence of asymptomatic and symptomatic malaria. Read More

    Larvicidal activity of essential oils of five Apiaceae taxa and some of their main constituents against Culex quinquefasciatus.
    Chem Biodivers 2017 Oct 9. Epub 2017 Oct 9.
    Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy.
    Apiaceae are aromatic herbs producing essential oils which are used on an industrial scale for various purposes. Notably, Apiaceae essential oils may replace synthetic insecticides keeping most of their efficacy and avoiding environmental pollution and human poisoning. In the present work, we explored the insecticidal potential of the essential oils from five Apiaceae taxa, namely Sison amomum, Echinophora spinosa, Heracleum sphondylium subsp. Read More

    Iron and iron oxide nanoparticles are highly toxic to Culex quinquefasciatus with little non-target effects on larvivorous fishes.
    Environ Sci Pollut Res Int 2017 Oct 7. Epub 2017 Oct 7.
    Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124, Pisa, Italy.
    The control of filariasis vectors has been enhanced in several areas, but there are main challenges, including increasing resistance to insecticides and lack of cheap and eco-friendly products. The toxicity of iron (Fe(0)) and iron oxide (Fe2O3) nanoparticles has been scarcely investigated yet. We studied the larvicidal and pupicidal activity of Fe(0) and Fe2O3 nanoparticles against Culex quinquefasciatus. Read More

    Lymphatic filariasis transmission on Mafia Islands, Tanzania: Evidence from xenomonitoring in mosquito vectors.
    PLoS Negl Trop Dis 2017 Oct 6;11(10):e0005938. Epub 2017 Oct 6.
    National Institute for Medical Research, Headquarters, Dar es Salaam, Tanzania.
    Introduction: Lymphatic filariasis (LF) is a chronic nematode infection transmitted by mosquitoes and in sub-Saharan Africa it is caused by Wuchereria bancrofti. The disease was targeted for global elimination by 2020 using repeated community-wide mass drug administration (MDA) distributed in endemic areas. However, recently, there has been a growing recognition of the potential role of including vector control as a supplement to MDA to achieve elimination goal. Read More

    In vitro and in vivo efficacies of novel carbazole aminoalcohols in the treatment of cystic echinococcosis.
    J Antimicrob Chemother 2017 Nov;72(11):3122-3130
    State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
    Objectives: Cystic echinococcosis (CE), caused by the cestode Echinococcus granulosus, is a worldwide chronic zoonosis. Current chemotherapeutic options are limited to albendazole and mebendazole, which only exert parasitostatic effects and have to be administered at high dosages for long periods. In an effort to find alternative treatment options, the in vitro and in vivo efficacies of novel carbazole aminoalcohols were evaluated. Read More

    Filiarial chyluria with nephrotic-range proteinuria and associated hypoalbuminaemia and hypogammaglobulinaemia secondary to bilateral lymphorenal fistulae.
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Department of Internal Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
    A 55-year-old man of Indian descent, presented to the emergency department with a 2-year history of passing 'milky' white urine, associated with dysuria, urinary retention, bilateral flank pain and 15 kg weight loss. He had migrated to Australia from India at the age of 16, with no overseas travel since, and denied having any fevers, rigours or chills. He was found to have chyluria and nephrotic-range proteinuria with marked hypoalbuminaemia and hypogammaglobulinaemia. Read More

    The rationale and cost-effectiveness of a confirmatory mapping tool for lymphatic filariasis: Examples from Ethiopia and Tanzania.
    PLoS Negl Trop Dis 2017 Oct 4;11(10):e0005944. Epub 2017 Oct 4.
    Neglected Tropical Disease Support Center, Task Force for Global Health, Atlanta, United States of America.
    Endemicity mapping is required to determining whether a district requires mass drug administration (MDA). Current guidelines for mapping LF require that two sites be selected per district and within each site a convenience sample of 100 adults be tested for antigenemia or microfilaremia. One or more confirmed positive tests in either site is interpreted as an indicator of potential transmission, prompting MDA at the district-level. Read More

    Feasibility of utilizing the SD BIOLINE Onchocerciasis IgG4 rapid test in onchocerciasis surveillance in Senegal.
    PLoS Negl Trop Dis 2017 Oct 3;11(10):e0005884. Epub 2017 Oct 3.
    PATH, Seattle, Washington, United States of America.
    As effective onchocerciasis control efforts in Africa transition to elimination efforts, different diagnostic tools are required to support country programs. Senegal, with its long standing, successful control program, is transitioning to using the SD BIOLINE Onchocerciasis IgG4 (Ov16) rapid test over traditional skin snip microscopy. The aim of this study is to demonstrate the feasibility of integrating the Ov16 rapid test into onchocerciasis surveillance activities in Senegal, based on the following attributes of acceptability, usability, and cost. Read More

    Therapeutic trial of doxycyclin plus ivermectin for the treatment of Brugia malayi naturally infected cats.
    Vet Parasitol 2017 Oct 18;245:42-47. Epub 2017 Aug 18.
    Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address:
    Lymphatic filariasis (LF) is one of the neglected tropical diseases which causes permanent and long term disability worldwide. LF is caused by filarial nematode parasites, i.e. Read More

    Community-based trial of annual versus biannual single-dose ivermectin plus albendazole against Wuchereria bancrofti infection in human and mosquito populations: study protocol for a cluster randomised controlled trial.
    Trials 2017 Oct 2;18(1):448. Epub 2017 Oct 2.
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana.
    Background: The Global Programme for the Elimination of Lymphatic Filariasis (GPELF) has been in operation since the year 2000, with the aim of eliminating the disease by the year 2020, following five to six rounds of effective annual mass drug administration (MDA). The treatment regimen is ivermectin (IVM) in combination with diethylcarbamazine (DEC) or albendazole (ALB). In Ghana, MDA has been undertaken since 2001. Read More

    Primary Intestinal Lymphangiectasia (Waldmann's Disease) Presenting with Chylous Effusions in a 15-Year-Old.
    J Clin Diagn Res 2017 Aug 1;11(8):OD17-OD18. Epub 2017 Aug 1.
    Professor, Department of Medicine, JIPMER, Puducherry, India.
    Primary Intestinal Lymphangiectasia (PIL) is a rare disease of unknown aetiology which presents in the paediatric age group with anasarca, diarrhoea, hypoproteinaemia, lymphoedema and chylous effusions. Tuberculosis, filariasis, chest trauma, malignancies and haematological disorders usually contribute to most cases of secondary lymphangiectasia and chylous effusions. We hereby describe a case of PIL presenting with chylous effusions which remained undiagnosed for eight years. Read More

    Microfilariae of Wuchereriabancrofti in Testicular Aspirate.
    J Clin Diagn Res 2017 Aug 1;11(8):ED19. Epub 2017 Aug 1.
    Pathologist, Department of Pathology, RML Mehrotra Pathology Ltd, Lucknow, Uttar Pradesh, India.
    Present study deals with results of fine needle aspiration of both the testes in a patient with azoospermia. Surprisingly, aspiration of right testis revealed large number of microfilariae in the smears. Conversely, left testicular aspirate showed few spermatogonia. Read More

    1 OF 323