Search our Database of Scientific Publications and Authors

I’m looking for a

    16288 results match your criteria Filariasis

    1 OF 326

    Correction to: prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa.
    Infect Dis Poverty 2018 Apr 20;7(1):38. Epub 2018 Apr 20.
    Department of Parasitology-Mycology, Faculty of Medicine, University of Health Sciences, P.O. Box 4009, Libreville, Gabon.
    Unfortunately, the original article [1] contained some errors. The table title of Tables 4, 5, 6, 7 were interchanged by mistake and displayed incorrectly in the article. The correct table titles of Tables 4, 5, 6, 7 can be found below. Read More

    Detection of Microfilariae in Follicular Fluid During Assisted Reproductive Technology: Case Report and Review of the Literature.
    Open Forum Infect Dis 2017 6;4(4):ofx208. Epub 2017 Oct 6.
    Service de Médecine et Biologie de la Reproduction, Cytogénétique, AMP et CECOS de Picardie, CHU d'Amiens, F-80054 Amiens cedex 1, France.
    We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. Read More

    Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion.
    PLoS Negl Trop Dis 2018 Apr 18;12(4):e0006404. Epub 2018 Apr 18.
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
    A number of features at the host-parasite interface are reminiscent of those that are also observed at the host-tumor interface. Both cancer cells and parasites establish a tissue microenvironment that allows for immune evasion and may reflect functional alterations of various innate cells. Here, we investigated how the phenotype and function of human monocytes is altered by exposure to cancer cell lines and if these functional and phenotypic alterations parallel those induced by exposure to helminth parasites. Read More

    Surveillance for lymphatic filariasis after stopping mass drug administration in endemic districts of Togo, 2010-2015.
    Parasit Vectors 2018 Apr 16;11(1):244. Epub 2018 Apr 16.
    Mectizan Donation Program, 325 Swanton Way, Decatur, GA, 30030, USA.
    Background: Togo is a country previously endemic for lymphatic filariasis (LF). In 2010, following nine years of mass drug administration (MDA) for LF, the country established a post-treatment surveillance (PTS) system. We present here the results of these PTS activities, carried out from 2010 to 2015, as well as the findings of follow-up investigations in 2016 to confirm the absence of infection in previously infected individuals. Read More

    Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin.
    PLoS Negl Trop Dis 2018 Apr 16;12(4):e0006438. Epub 2018 Apr 16.
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America.
    The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis. The capability of B. malayi and other parasitic nematodes to modulate host biology is recognized but the mechanisms by which such manipulation occurs are obscure. Read More

    Effects of antibiotic treatment on the fecundity of Rhipicephalus haemaphysaloides ticks.
    Parasit Vectors 2018 Apr 13;11(1):242. Epub 2018 Apr 13.
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite & Vector Biology, Ministry of Health, Shanghai, 200025, People's Republic of China.
    Background: Endosymbiotic bacteria inhabit a variety of arthropods including ticks and may have multiple effects on the host's survival, reproduction or pathogen acquisition and transmission. Rhipicephalus haemaphysaloides is one of the most widely distributed tick species in China. The symbiotic bacteria composition and their impacts to R. Read More

    Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models.
    Sci Rep 2018 Apr 12;8(1):5910. Epub 2018 Apr 12.
    Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
    Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. Read More

    Insulin receptor knockdown blocks filarial parasite development and alters egg production in the southern house mosquito, Culex quinquefasciatus.
    PLoS Negl Trop Dis 2018 Apr 12;12(4):e0006413. Epub 2018 Apr 12.
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada, United States of America.
    Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. Wuchreria bancrofti (Wb) is responsible for >90% of infections and the remainder are caused by Brugia spp. Mosquitoes of the genera Culex (in urban and semi-urban areas), Anopheles (in rural areas of Africa and elsewhere), and Aedes (in Pacific islands) are the major vectors of W. Read More

    Status of lymphatic filariasis with progression of age and gender & eradication strategies: A survey among residents of Hardoi district of Uttar Pradesh, an endemic region of North India.
    Cell Mol Biol (Noisy-le-grand) 2018 Mar 31;64(4):46-51. Epub 2018 Mar 31.
    Council of Science and Technology, Lucknow, UP, India.
    Lymphatic filariasis (LF) is a chronic and debilitating disease that affects people in tropical and sub-tropical areas of Asia, Africa, and Western Pacific. It is one of the leading community health problems in some of the endemic districts in India including Hardoi district of Uttar Pradesh. The disease is caused by the parasites Wuchereria bancrofti (W. Read More

    Insights from agriculture for the management of insecticide resistance in disease vectors.
    Evol Appl 2018 Apr 29;11(4):404-414. Epub 2017 Jun 29.
    Department of Entomology and Center for Infectious Disease DynamicsThe Pennsylvania State UniversityUniversity ParkPAUSA.
    Key to contemporary management of diseases such as malaria, dengue, and filariasis is control of the insect vectors responsible for transmission. Insecticide-based interventions have contributed to declines in disease burdens in many areas, but this progress could be threatened by the emergence of insecticide resistance in vector populations. Insecticide resistance is likewise a major concern in agriculture, where insect pests can cause substantial yield losses. Read More

    Isolated Epitrochlear Filarial Lymphadenopathy: Cytomorphological Diagnosis of an Unusual Presentation.
    Turk Patoloji Derg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, NEW DELHI, INDIA.
    Filariasis is a major public health problem in tropical countries like India. Despite the large number of people at risk, detection of eggs with or without larva (microfilaria) on fine-needle aspiration cytology is very unusual, especially in an uncommon site or incidentally detected in clinically unsuspected cases of filariasis with the absence of microfilariae in the peripheral blood. A 19-year-old male presented with swelling over medial aspect of left arm (just above the elbow), with no other specific signs and symptoms. Read More

    Filaria specific antibody response profiling in plasma from anti-retroviral naïve Loa loa microfilaraemic HIV-1 infected people.
    BMC Infect Dis 2018 Apr 4;18(1):160. Epub 2018 Apr 4.
    Laboratory of vaccinology/biobanking, CIRCB, Messa, Yaounde, Cameroon.
    Background: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis. Read More

    Heterogeneity in the in vitro susceptibility of Loa loa microfilariae to drugs commonly used in parasitological infections.
    Parasit Vectors 2018 Apr 4;11(1):223. Epub 2018 Apr 4.
    Parasites and Vectors Biology Research Unit (PAVBRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
    Background: Co-infection with loiasis remains a potential problem in control programs targeting filarial infections. The effects of many anti-parasitic drugs often administered to Loa loa infected people are not well documented. This study compared the in vitro activity of several of these drugs on the viability of L. Read More

    Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.
    Lancet Infect Dis 2018 Mar 27. Epub 2018 Mar 27.
    Liverpool School of Tropical Medicine, Liverpool, UK.
    Background: Ivermectin is being considered for mass drug administration for malaria due to its ability to kill mosquitoes feeding on recently treated individuals. However, standard, single doses of 150-200 μg/kg used for onchocerciasis and lymphatic filariasis have a short-lived mosquitocidal effect (<7 days). Because ivermectin is well tolerated up to 2000 μg/kg, we aimed to establish the safety, tolerability, and mosquitocidal efficacy of 3 day courses of high-dose ivermectin, co-administered with a standard malaria treatment. Read More

    Brugia malayi infection in ferrets - A small mammal model of lymphatic filariasis.
    PLoS Negl Trop Dis 2018 Mar 30;12(3):e0006334. Epub 2018 Mar 30.
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America.
    Background: The lack of effective short-course therapies for treatment of the adult stage of filarial worms is a major limitation in the global effort to eliminate lymphatic filariasis. Studies using current small mammal models of lymphatic filariasis are limited by difficulties in quantifying adult worm numbers and in assessing lymphatic anatomy and function.

    Methodology/principal Findings: Here, we re-established Brugia malayi infection of ferrets as a model for lymphatic filariasis and demonstrated parasitological, immunological, and histological parallels with human infection. Read More

    Evaluation of the recombinant antigens Wb14 and WbT for the capture antibody diagnosis of lymphatic filariasis.
    Mem Inst Oswaldo Cruz 2018 Mar 26;113(5):e170435. Epub 2018 Mar 26.
    Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Recife, PE, Brasil.
    Background: Lymphatic filariasis (LF) is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis) and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity) and limited diagnostic kits. Read More

    Report of the first international workshop on onchocerciasis-associated epilepsy.
    Infect Dis Poverty 2018 Mar 22;7(1):23. Epub 2018 Mar 22.
    Makerere University, College of Health Sciences, Kampala, Uganda.
    Background: Recently, several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy (OAE) may constitute an important but neglected public health problem in many countries where onchocerciasis is still endemic.

    Main Text: On October 12-14 2017, the first international workshop on onchocerciasis-associated epilepsy (OAE) was held in Antwerp, Belgium. The workshop was attended by 79 participants from 20 different countries. Read More

    Results of a confirmatory mapping tool for Lymphatic filariasis endemicity classification in areas where transmission was uncertain in Ethiopia.
    PLoS Negl Trop Dis 2018 Mar 26;12(3):e0006325. Epub 2018 Mar 26.
    The Task Force for Global Health, Atlanta Georgia, United States of America.
    Background: The goal of the global lymphatic filariasis (LF) program is to eliminate the disease as a public health problem by the year 2020. The WHO mapping protocol that is used to identify endemic areas in need of mass drug administration (MDA) uses convenience-based sampling. This rapid mapping has allowed the global program to dramatically scale up treatment, but as the program approaches its elimination goal, it is important to ensure that all endemic areas have been identified and have received MDA. Read More

    Apoptotic impact on Brugia malayi by sulphonamido-quinoxaline: search for a novel therapeutic rationale.
    Parasitol Res 2018 Mar 23. Epub 2018 Mar 23.
    School of Pharmacy, S.R.T.M. University, Nanded, Maharashtra, 436306, India.
    Human lymphatic filariasis although not fatal but poses serious socioeconomic burden due to associated disability. This is reflected by the huge magnitude of the estimated disability-adjusted life years of about 5.09 million. Read More

    First things first: Importance of eosinophil count in diagnosing occult parasites.
    Drug Discov Ther 2018 ;12(1):55-57
    Department of Radiology, All India Institute of Medical Sciences.
    Tropical pulmonary eosinophilia (TPE) is a rare allergic manifestation to the filarial nematode. A 38-year old male and a 15-year old female presented with cough and breathlessness. Their complete blood count showed eosinophilia. Read More

    A Storytelling Approach: Insights from the Shambaa.
    J Med Humanit 2018 Mar 19. Epub 2018 Mar 19.
    Stellenbosch University, Stellenbosch, South Africa.
    Narrative medicine explores the stories that patients tell; this paper, conversely, looks at some of the stories that patients are told. The paper starts by examining the 'story' told by the Shambaa people of Tanzania to explain the bubonic plague and contrasts this with the stories told by Ghanaian communities to explain lymphatic filariasis. By harnessing insights from memory studies, these stories' memorability is claimed to be due to their use mnemonic devices woven into stories. Read More

    Chyluria in young child: a rare presentation.
    BMJ Case Rep 2018 Mar 16;2018. Epub 2018 Mar 16.
    Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.
    Chyluria, a chronic manifestation of lymphatic filariasis, is rare in children. Clinicians must have a high index of suspicion to diagnose this condition in children as it mimics nephrotic syndrome. We present an unusual case in which a 7-year-old boy hailing from a filarial endemic region presented with a passage of milky urine, which on evaluation was diagnosed as parasitic chyluria. Read More

    Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.
    ACS Med Chem Lett 2018 Mar 9;9(3):210-214. Epub 2018 Feb 9.
    Sokol Institute for Pharmaceutical Life Sciences and Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.
    Lymphatic filariasis infects over 120 million people worldwide and can lead to significant disfigurement and disease. Resistance is emerging with current treatments, and these therapies have dose limiting adverse events; consequently new targets are needed. One approach to achieve this goal is inhibition of parasitic protein kinases involved in circumventing host defense mechanisms. Read More

    Biomphalaria camerunensis as a viable alternative intermediate host for Schistosoma mansoni in southern Cameroon.
    Parasit Vectors 2018 Mar 13;11(1):181. Epub 2018 Mar 13.
    Parasitology and Ecology Laboratory, Faculty of Science, University of Yaoundé 1, PO Box 812, Yaoundé, Cameroon.
    Background: Intestinal schistosomiasis due to Schistosoma mansoni was mapped in Cameroon in the 1990s and preventive chemotherapy launched since 2005. A situation analysis conducted in 2011 revealed an increase in schistosomiasis transmission, especially in the equatorial part of the country, despite the fact that Biomphalaria pfeifferi, the main intermediate host of this parasite, is now scarce in many foci. Biomphalaria camerunensis, restricted to the equatorial part of the country, is considered as a less suitable host for S. Read More

    The role of gender relations in uptake of mass drug administration for lymphatic filariasis in Alor District, Indonesia.
    Parasit Vectors 2018 Mar 12;11(1):179. Epub 2018 Mar 12.
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, Faculty of Public Health and Policy, Keppel Street, London, WC1E 7HT, UK.
    Background: The Global Programme to Eliminate Lymphatic Filariasis has set 2020 as a target to eliminate lymphatic filariasis (LF) as a public health problem through mass drug administration (MDA) to all eligible people living in endemic areas. To obtain a better understanding of compliance with LF treatment, a qualitative study using 43 in-depth interviews was carried out in Alor District, Indonesia to explore factors that motivate uptake of LF treatment, including the social and behavioural differences between compliant and non-compliant individuals. In this paper, we report on the findings specific to the role of family and gender relations and how they affect compliance. Read More

    Comparison of antigen and antibody responses in repeat lymphatic filariasis transmission assessment surveys in American Samoa.
    PLoS Negl Trop Dis 2018 Mar 9;12(3):e0006347. Epub 2018 Mar 9.
    Department of Health, Lymphatic Filariasis Elimination Program, Pago Pago, American Samoa.
    Background: Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activities beyond the recommended transmission assessment survey (TAS).

    Methodology: TAS was first conducted in American Samoa in 2011 (TAS 1) and a repeat TAS was carried out in 2015 (TAS 2). Read More

    Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China.
    Malar J 2018 Mar 5;17(1):103. Epub 2018 Mar 5.
    Henan Center for Disease Control and Prevention, Zhengzhou, Henan, China.
    Background: Plasmodium vivax malaria has historically been a major source of disease in Henan, China. In the 1970s, the morbidity of malaria was highest in the country. With support from the government and the efforts of healthcare personnel, the reported malaria cases have declined dramatically and a national elimination programme was launched in 2010. Read More

    Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis.
    Int J Parasitol 2018 Apr 6;48(5):371-378. Epub 2018 Mar 6.
    National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
    Brugia malayi is a causative agent of lymphatic filariasis, a major tropical disease. The infective L3 parasite stage releases immunomodulatory proteins including the venom allergen-like proteins (VALs), which are members of the SCP/TAPS (Sperm-coating protein/Tpx/antigen 5/pathogenesis related-1/Sc7) superfamily. BmVAL-1 is a major target of host immunity with >90% of infected B. Read More

    Behavioural and clinical predictors for Loiasis.
    J Glob Health 2018 Jun;8(1):010413
    Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
    Background: Loiasis is a vector-borne disease in Central and West Africa. While there is still uncertainty to what extent loiasis is responsible for population morbidity, individuals having both loiasis and onchocerciasis have a high risk of fatal encephalopathy when treatment (ie, ivermectin) for onchocerciasis is given. Therefore it is current policy that communities of high loiasis-burden are excluded from mass drug administration programmes of ivermectin. Read More

    Infective Larvae of Induce Polarization of Host Macrophages that Helps in Immune Evasion.
    Front Immunol 2018 12;9:194. Epub 2018 Feb 12.
    Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
    Filarial parasites suppress, divert, or polarize the host immune response to aid their survival. However, mechanisms that govern the polarization of host MΦs during early filarial infection are not completely understood. In this study, we infected BALB/c mice with infective larvae stage-3 of (Bm-L3) and studied their effect on the polarization of splenic MΦs. Read More

    Operationalization of the test and not treat strategy to accelerate the elimination of onchocerciasis and lymphatic filariasis in Central Africa.
    Int Health 2018 Mar;10(suppl_1):i49-i53
    IRD UMI 233-INSERM U1175-Montpellier University, Montpellier, France.
    After 30 years of treatment with Mectizan (ivermectin), cutaneous and ocular complications of Onchocerca volvulus infection are now scarce in endemic communities. Indeed, transmission has been interrupted and the O. volvulus- associated disease has disappeared in some African foci. Read More

    How elimination of lymphatic filariasis as a public health problem in the Kingdom of Cambodia was achieved.
    Infect Dis Poverty 2018 Feb 20;7(1):15. Epub 2018 Feb 20.
    National Centre for Parasitology, Entomology and Malaria Control, Ministry of Health, 477 Betong Street (Corner St.92), Village Trapangsvay, Sanakat Phnom Penh Thmey, Khan Sensok, Phnom Penh, Cambodia.
    Background: Endemicity of lymphatic filariasis (LF) in Cambodia was proven in 1956 when microfilariae were detected in mosquitos in the Kratié province. In 2001, an extensive study confirmed the presence of both Brugia malayi and Wuchereria bancrofti microfilariae. In 2003, the Ministry of Health established a national task force to develop policies and strategies for controlling and eliminating neglected tropical diseases (NTDs), with the goal of eliminating LF by 2015. Read More

    Management of arthropod vector data - Social and ecological dynamics facing the One Health perspective.
    Acta Trop 2018 Jun 16;182:80-91. Epub 2018 Feb 16.
    Benjamin Franklin Institute of Technology, Boston, MA, United States.
    Emerging infectious diseases (EIDs) are spread by direct and/or indirect contacts between a pathogen or parasite and their hosts. Arthropod vectors have evolved as excellent bloodsuckers, providing an elegant transportation mode for a wide number of infectious agents. The nature of pathogen and parasite transfer and the models used to predict how a disease might spread are magnified in complexity when an arthropod vector is part of the disease cycle. Read More

    Subconjunctival ocular filariasis -Case report.
    Rom J Ophthalmol 2017 Jan-Mar;61(1):76-79
    County Emergency Hospital, Cluj-Napoca, Romania.
    We are presenting the case of a patient who was clinically diagnosed with subconjunctival ocular dirofilariasis, confirmed by the parasitological examination. The treatment consisted in the surgical extraction of the parasite, a local treatment with antibiotics and steroidal anti-inflammatory mydriatic and general treatment with antihelminthic, antibiotic, analgesic, and anti-inflammatory drugs. The intraoperative and postoperative evolution of the case was favorable. Read More

    Multiplex serology for impact evaluation of bed net distribution on burden of lymphatic filariasis and four species of human malaria in northern Mozambique.
    PLoS Negl Trop Dis 2018 Feb 14;12(2):e0006278. Epub 2018 Feb 14.
    Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, United States of America.
    Background: Universal coverage with long-lasting insecticidal nets (LLINs) is a primary control strategy against Plasmodium falciparum malaria. However, its impact on the three other main species of human malaria and lymphatic filariasis (LF), which share the same vectors in many co-endemic areas, is not as well characterized. The recent development of multiplex antibody detection provides the opportunity for simultaneous evaluation of the impact of control measures on the burden of multiple diseases. Read More

    Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment.
    BMC Public Health 2018 02 13;18(1):238. Epub 2018 Feb 13.
    Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O Box LG 581, Legon-Accra, Ghana.
    Background: The Global Program for the Elimination of Lymphatic Filariasis (GPELF) started operation in 2000 and aimed at eliminating the disease by the year 2020, following 5-6 rounds of effective annual Mass Drug Administration (MDA). The MDA programme took off in Ghana in 2001 and has interrupted transmission in many areas while it has persisted in some areas after 10 or more rounds of MDA. This study was to appreciate community members' perspectives on MDA after over 15 years of implementation. Read More

    Estimation of the number of women of reproductive age in need of preventive chemotherapy for soil-transmitted helminth infections.
    PLoS Negl Trop Dis 2018 Feb 12;12(2):e0006269. Epub 2018 Feb 12.
    Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.
    Background: Soil-transmitted helminth infections are among the most common infections in developing countries. Globally, as many as 2 billion people are considered to be at risk for soil-transmitted-helminth (STH) infections. Preschool children (PSAC), school-age children (SAC) and women of reproductive age (WRA) are at high risk of STH-attributable morbidity and preventive chemotherapy (PC) for STH is recommended by the World health Organization (WHO). Read More

    (Papaya) latex: a new paradigm to combat against dengue and filariasis vectors and (Diptera: Culicidae).
    3 Biotech 2018 Feb 16;8(2):83. Epub 2018 Jan 16.
    1Department of Biotechnology, School of Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu India.
    This study manifests the larvicidal efficacy of latex extract and silver nanoparticles (CPAgNPs) synthesized using latex, against developing immature juveniles of and . Briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. The obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. Read More

    Sensitivity of diagnostic methods for Mansonella ozzardi microfilariae detection in the Brazilian Amazon Region.
    Mem Inst Oswaldo Cruz 2018 Mar;113(3):173-177
    Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Gerência de Parasitologia, Manaus, AM, Brasil.
    Background: The human filarial worm Mansonella ozzardi is highly endemic in the large tributaries of the Amazon River. This infection is still highly neglected and can be falsely negative when microfilariae levels are low.

    Objectives: This study investigated the frequency of individuals with M. Read More

    Island-Wide Surveillance of Gastrointestinal Protozoan Infection on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform.
    Am J Trop Med Hyg 2018 Apr 1;98(4):1179-1185. Epub 2018 Feb 1.
    Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
    As part of lymphatic filariasis (LF) transmission assessment surveys (TAS) on Fiji, an island-wide assessment of gastrointestinal protozoan infection was performed by inspection of a concomitant stool sample collection to investigate the distribution of parasitic protozoa. All grade 1 and 2 students of 69 schools on the two main islands were targeted in two phases (one in the Western Division and the other in the Central and Northern Divisions, except Taveuni sub-Division of Northern), where fecal samples of 1,800 students were available for coproscopy using formalin-ether-acetate concentration. The overall prevalence of infection was 1. Read More

    Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary?
    Lancet Infect Dis 2018 Feb 2. Epub 2018 Feb 2.
    Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.
    Lymphatic filariasis in Africa is caused by the parasite Wuchereria bancrofti and remains a major cause of morbidity and disability in 74 countries globally. A key strategy of the Global Programme for the Elimination of Lymphatic Filariasis, which has a target elimination date of 2020, is the treatment of entire endemic communities through mass drug administration of albendazole in combination with either ivermectin or diethylcarbamazine. Although the strategy of mass drug administration in combination with other interventions, such as vector control, has led to elimination of the infection and its transmission in many rural communities, urban areas in west Africa present specific challenges to achieving the 2020 targets. Read More

    Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs.
    Parasit Vectors 2018 Feb 1;11(1):75. Epub 2018 Feb 1.
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.
    In 2000, the World Health Organization established the Global Programme to Eliminate Lymphatic Filariasis (GPELF), with the goal of eliminating the disease as a public health problem by 2020. Since the start of the programme, a cumulative total of 6.2 billion treatments have been delivered to affected populations - with more than 556 million people treated in 2015 alone. Read More

    Cord Blood Antiparasite Interleukin 10 as a Risk Marker for Compromised Vaccine Immunogenicity in Early Childhood.
    J Infect Dis 2018 Apr;217(9):1426-1434
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio.
    Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' antiparasite cytokine profiles relate to immunoglobulin G (IgG) responses to standard vaccination during infancy.

    Methods: A total of 450 Kenyan women were tested for parasitic infections during pregnancy. Read More

    Filaria surveys in the Armed Forces: Need for a revisit.
    Med J Armed Forces India 2017 Oct 17;73(4):332-337. Epub 2016 Nov 17.
    Associate Professor, Dept of Community Medicine, Armed Forces Medical College, Pune 411040, India.
    Background: Routine annual filarial surveys are conducted amongst various categories of military personnel and their families as per policies in vogue in the Armed Forces. The neglect and inattention faced by this disease needs to be addressed in terms of policy, provisioning and processes while dealing with filariasis in the Armed Forces.

    Methods: Routine annual filarial survey was conducted in a garrison during the months of Nov and Dec in 2013 and 2014. Read More

    Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis.
    Proc Biol Sci 2018 Jan;285(1871)
    Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
    It is well known that individuals in the same community can be exposed to a highly variable number of mosquito bites. This heterogeneity in bite exposure has consequences for the control of vector-borne diseases because a few people may be contributing significantly to transmission. However, very few studies measure sources of heterogeneity in a way which is relevant to decision-making. Read More

    Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns.
    Parasit Vectors 2018 Jan 31;11(1):70. Epub 2018 Jan 31.
    Department of Disease Control, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
    Background: Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upon community-directed mass administration of ivermectin (CDTI) for onchocerciasis, and ivermectin plus albendazole for LF, with evidence pointing towards the potential for novel drug regimens. When distributing microfilaricides however, considerable care is needed to minimise the risk of severe adverse events (SAEs) in areas that are co-endemic for onchocerciasis or LF and loiasis. Read More

    1 OF 326