16,786 results match your criteria Filariasis


Systematic sampling of adults as a sensitive means of detecting persistence of lymphatic filariasis following mass drug administration in Sri Lanka.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007365. Epub 2019 Apr 22.

Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, United States of America.

Background: Sri Lanka's Anti-Filariasis Campaign conducted 5 annual rounds of mass drug administration (MDA) with diethylcarbamazine (DEC) plus albendazole to eliminate lymphatic filariasis (LF) in all endemic districts between 2002 and 2006. Post-MDA surveillance has consistently documented Wuchereria bancrofti microfilaremia (Mf) rates below 1% in all sentinel and spot check sites since that time, and all implementation units easily satisfied WHO's target for school-based transmission assessment surveys (school-TAS) in 2013. However, more detailed studies have identified foci of persistent infection in the large coastal evaluation unit (EU) (population about 0. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007365DOI Listing

Incrimination of for dengue virus serotype-1 in Assam, Northeast India.

J Vector Borne Dis 2018 Oct-Dec;55(4):330-333

Division of Entomology and Filariasis, ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, Assam, India.

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http://dx.doi.org/10.4103/0972-9062.256572DOI Listing
April 2019
3 Reads

Detection and distribution of endobacteria in populations (Diptera : Culicidae) from Metropolitan Manila, Philippines.

J Vector Borne Dis 2018 Oct-Dec;55(4):265-270

Department of Civil and Environmental Engineering, Ehime University, Matsuyama, Japan; Biological Control Research Unit, Center for Natural Science and Environmental Research, De La Salle University, Taft Ave Manila, Philippines.

Background & Objectives: Culex quinquefasciatus is a peridomestic mosquito known for its ability to transmit pathogenic diseases such as filariasis and Japanese encephalitis. The development and use of novel and innovative vector control measures such as the utilization of Wolbachia, along with the existing ones, are necessary to prevent the transmission of these diseases. Studies exploring the diversity of Wolbachia, particularly in Cx. Read More

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http://dx.doi.org/10.4103/0972-9062.256561DOI Listing
April 2019
1 Read

Systematic Review of Lesser Known Parasitoses: Maxillofacial Dirofilariasis.

J Maxillofac Oral Surg 2019 Jun 2;18(2):180-189. Epub 2018 Aug 2.

6Department of Pathology, AIIMS Jodhpur, Jodhpur, India.

Background: Dirofilariasis is an endemic disease in tropical and subtropical countries caused by about 40 different species of dirofilari. Dirofilariasis of the oral cavity is extremely rare and is usually seen as mucosal or submucosal nodules. We also present a case of dirofilariasis of the mandibular third molar region submucosally in a 26 year old male patient. Read More

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http://dx.doi.org/10.1007/s12663-018-1139-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441424PMC

The authors' reply to "Both Macro and Micro Filarial Treatment May be Necessary to Treat Hydrocele Due to a Wuchereria bancrofti Infection".

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2840-19DOI Listing

The Concept of Chronic Edema-A Neglected Public Health Issue and an International Response: The LIMPRINT Study.

Lymphat Res Biol 2019 Apr;17(2):121-126

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

Lymphedema has always been a neglected global health care problem. A central requirement for the development of any chronic disease is the clear use of public health definitions that can be used internationally to define populations. The term "lymphedema" has historically been defined as either primary, resulting from failure of lymphatic development, or secondary, following damage to the lymphatics (e. Read More

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http://dx.doi.org/10.1089/lrb.2018.0085DOI Listing
April 2019
1 Read

[Technique for extracting ocular filariasis].

J Fr Ophtalmol 2019 Apr 10. Epub 2019 Apr 10.

Service d'ophtalmologie de l'hôpital d'instruction des Armées Omar Bongo Ondimba, 20404 Libreville, Gabon.

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http://dx.doi.org/10.1016/j.jfo.2018.12.008DOI Listing
April 2019
3 Reads

Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans.

Parasit Vectors 2019 Apr 11;12(1):166. Epub 2019 Apr 11.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Background: Culicoides (Diptera; Ceratoponidae) are tiny, stout, blood-sucking flies with a near worldwide distribution. When present, they are often considered a biting nuisance but in addition, they are involved in the transmission of pathogens to humans, domestic and wild animals. Data on Culicoides species in the South-West region of Cameroon dates back to the 1950s. Read More

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http://dx.doi.org/10.1186/s13071-019-3432-9DOI Listing

Trends in insecticide resistance in Culex pipiens pallens over 20 years in Shandong, China.

Parasit Vectors 2019 Apr 11;12(1):167. Epub 2019 Apr 11.

Department of Medical Entomology, Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Jining, 272033, Shandong, People's Republic of China.

Background: Culex pipiens pallens is the most abundant Culex mosquito species in northern China and is an important vector of bancroftian filariasis and, potentially, West Nile virus. Insecticides, particularly pyrethroids, are widely used for adult mosquito control. Insecticide resistance has become common in several mosquito species, and vector control is the main method currently available to prevent disease transmission. Read More

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http://dx.doi.org/10.1186/s13071-019-3416-9DOI Listing
April 2019
1 Read

EBM verdict: should albendazole be used for treating lymphatic filariasis? No.

Authors:
Igho J Onakpoya

BMJ Evid Based Med 2019 Apr 10. Epub 2019 Apr 10.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111184DOI Listing

Risk factors for lymphatic filariasis in two villages of the Democratic Republic of the Congo.

Parasit Vectors 2019 Apr 11;12(1):162. Epub 2019 Apr 11.

IRD UMI 233, INSERM U1175, Université de Montpellier, Unité TransVIHMI, 911 Avenue Agropolis, P.O. Box 64501, 34394, Montpellier, France.

Background: Little is known regarding risk factors for lymphatic filariasis (LF) in Central Africa. To expand on what is known, we studied the epidemiology of LF in two endemic villages in the Democratic Republic of the Congo.

Methods: Dependent variables were Wuchereria bancrofti antigenaemia detected with filarial test strips (FTS) and microfilaraemia detected by night blood smears. Read More

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http://dx.doi.org/10.1186/s13071-019-3428-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458702PMC
April 2019
6 Reads

Effect of a Single Standard Dose (150-200 μg/kg) of Ivermectin on Microfilaremia: Systematic Review and Meta-analysis.

Open Forum Infect Dis 2019 Apr 11;6(4):ofz019. Epub 2019 Jan 11.

IRD UMI 233-INSERM U1175- University of Montpellier, Montpellier, France.

Background: In central Africa, millions of individuals infected with have received the anthelminthic drug ivermectin (IVM) as part of mass drug administration (MDA) campaigns targeting onchocerciasis control or elimination. Nonetheless, the parasitological surveys that are occasionally conducted to evaluate the impact of IVM treatments on do not include an assessment of the extra benefits of those MDA campaigns on .

Methods: We conducted a systematic review of trials on the effect of a single standard (150-200 μg/kg) dose of IVM on microfilarial density (MFD). Read More

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http://dx.doi.org/10.1093/ofid/ofz019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449757PMC

Diagnosis of feline filariasis assisted by a novel semi-automated microfluidic device in combination with high resolution melting real-time PCR.

Parasit Vectors 2019 Apr 8;12(1):159. Epub 2019 Apr 8.

Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: The diagnosis of filariasis traditionally relies on the detection of circulating microfilariae (mf) using Giemsa-stained thick blood smears. This approach has several limitations. We developed a semi-automated microfluidic device to improve and simplify the detection of filarial nematodes. Read More

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http://dx.doi.org/10.1186/s13071-019-3421-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454708PMC

Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.

SLAS Discov 2019 Apr 8:2472555219838341. Epub 2019 Apr 8.

1 Centre for Drugs and Diagnostics Research, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

The Anti- Wolbachia (A·WOL) consortium at the Liverpool School of Tropical Medicine (LSTM) has partnered with the Global High-Throughput Screening (HTS) Centre at AstraZeneca to create the first anthelmintic HTS for neglected tropical diseases (NTDs). The A·WOL consortium aims to identify novel macrofilaricidal drugs targeting the essential bacterial symbiont ( Wolbachia) of the filarial nematodes causing onchocerciasis and lymphatic filariasis. Working in collaboration, we have validated a robust high-throughput assay capable of identifying compounds that selectively kill Wolbachia over the host insect cell. Read More

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http://dx.doi.org/10.1177/2472555219838341DOI Listing
April 2019
2 Reads

Therapeutic efficacy of doxycycline in domestic cats naturally infected with Brugia malayi in field condition.

Exp Parasitol 2019 Apr 4;200:73-78. Epub 2019 Apr 4.

Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Objective: The aim of this study was to evaluate the efficacy of oral doxycycline treatment for Brugia malayi as measured by microfilarial and filarial DNA clearance in naturally infected domestic cats.

Methods: This study included 8 domestic cats that lived with families that resided in Tak Bai District of Narathiwat Province, which is located in Southern Thailand. The study area is a known B. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.03.016DOI Listing
April 2019
1 Read

The Endosymbionts.

Microbiol Spectr 2019 03;7(2)

CRBM, University of Montpellier, CNRS, Montpellier, France.

The endosymbionts encompass a large group of intracellular bacteria of biomedical and veterinary relevance, closely related to , , and . This genus of Gram-negative members of the does not infect vertebrates but is instead restricted to ecdysozoan species, including terrestrial arthropods and a family of parasitic filarial nematodes, the Onchocercidae. The profoundly impact not only the ecology and evolution but also the reproductive biology of their hosts, through a wide range of symbiotic interactions. Read More

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http://dx.doi.org/10.1128/microbiolspec.BAI-0018-2019DOI Listing
March 2019
1 Read

Penile and scrotal lymphedema associated with hidradenitis suppurativa: Case report and review of surgical options.

Cir Cir 2019 ;86(1):77-80

Department of Plastic Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.

Lymphedema is the result of an alteration of the lymphatic drainage, and its most common worldwide cause is filariasis. In our practice usually is associated to neoplasic, inflammatory and granulomatous processes, radiotherapy, hydroelectrolytic disbalances, and idiopathic. It can affect any part of the body, including the penis and scrotum. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000012DOI Listing
January 2019
5 Reads

New HPLC-MS method for rapid and simultaneous quantification of doxycycline, diethylcarbamazine and albendazole metabolites in rat plasma and organs after concomitant oral administration.

J Pharm Biomed Anal 2019 Mar 26;170:243-253. Epub 2019 Mar 26.

School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK. Electronic address:

A sensitive and relatively fast, cost-effective high-performance liquid chromatographic method coupled with mass spectrometer (HPLC-MS) is herein reported for the first time for a simultaneous quantification of plasma and organs concentration of three therapeutic agents that are widely used in treatment of lymphatic filariasis (LF), namely, doxycycline (DOX), diethylcarbamazine (DEC) and albendazole (ABZ) metabolites. The method was developed and validated as per ICH and FDA guidelines and successfully employed to quantify DOX, DEC and ABZ metabolites (albendazole sulfoxide (ABZ-OX) and albendazole sulfone (ABZ-ON)) in the plasma and organs of Sprague Dawley rats after oral concomitant administration of the above mentioned therapeutic agents. Importantly, a simple, one-step protein precipitation and extraction method was used to extract the four compounds efficiently with a recovery in the range of 79. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.047DOI Listing
March 2019
4 Reads
2.979 Impact Factor

Culex species diversity, susceptibility to insecticides and role as potential vector of Lymphatic filariasis in the city of Yaoundé, Cameroon.

PLoS Negl Trop Dis 2019 Apr 3;13(4):e0007229. Epub 2019 Apr 3.

Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contreles Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon.

Background: Culex species are widespread across Cameroon and responsible for high burden of nuisance in most urban settings. However, despite their high nuisance, they remain less studied compared to anophelines. The present study aimed to assess Culex species distribution, susceptibility to insecticide, bionomics and role in Lymphatic Filariasis (LF) transmission in the city of Yaoundé. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007229DOI Listing
April 2019
2 Reads

The composition and abundance of bacterial communities residing in the gut of Glossina palpalis palpalis captured in two sites of southern Cameroon.

Parasit Vectors 2019 Apr 2;12(1):151. Epub 2019 Apr 2.

INTERTRYP, Institut de Recherche pour le Développement, University of Montpellier, Montpellier, France.

Background: A number of reports have demonstrated the role of insect bacterial flora on their host's physiology and metabolism. The tsetse host and vector of trypanosomes responsible for human sleeping sickness (human African trypanosomiasis, HAT) and nagana in animals (African animal trypanosomiasis, AAT) carry bacteria that influence its diet and immune processes. However, the mechanisms involved in these processes remain poorly documented. Read More

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http://dx.doi.org/10.1186/s13071-019-3402-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444424PMC
April 2019
3 Reads

The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.

Pathogens 2019 Mar 25;8(1). Epub 2019 Mar 25.

Lymphatic Filariasis and Tropical Medicine Research Unit, Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Lymphatic filariasis, caused by lymphatic filarial parasites, and , causes significant morbidity and disability to 120 million people in the tropics and subtropics. Chitin has an important role for embryogenesis in adult worms and is a component of microfilaria sheath. Human chitotriosidase (CHIT1) is a chitin-degrading enzyme which provides a protective role against chitin-containing pathogens. Read More

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http://dx.doi.org/10.3390/pathogens8010041DOI Listing
March 2019
1 Read

Geographical distribution and prevalence of podoconiosis in Rwanda: a cross-sectional country-wide survey.

Lancet Glob Health 2019 May 27;7(5):e671-e680. Epub 2019 Mar 27.

Wellcome Trust Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, UK; School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Podoconiosis is a type of tropical lymphoedema that causes massive swelling of the lower limbs. The disease is associated with both economic insecurity, due to long-term morbidity-related loss of productivity, and intense social stigma. Reliable and detailed data on the prevalence and distribution of podoconiosis are scarce. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193007
Publisher Site
http://dx.doi.org/10.1016/S2214-109X(19)30072-5DOI Listing
May 2019
3 Reads

Use of Anopheles salivary biomarker to assess seasonal variation of human exposure to bites in children living near rubber and oil palm cultivations in Côte d'Ivoire.

Parasite Epidemiol Control 2019 May 7;5:e00102. Epub 2019 Mar 7.

Institut Pierre Richet (IPR), Institut National de Santé Publique (INSP), 01 BP 1500, Bouaké 01, Côte d'Ivoire.

Environmental changes related to agricultural practices and activities can impact malaria transmission. In the objective to evaluate this impact on the human-vector contact, the level of human exposure to vector bites was assess by an immuno-epidemiological indicator based on the assessment of the human IgG antibody response to the gSG6-P1 salivary peptide, previously validated as a pertinent biomarker. Two cross-sectional surveys were carried out in the dry and rainy season in three villages with intensive agricultural plantations (N'Zikro with rubber cultivation, Ehania-V5 and Ehania-V1 with palm oil exploitation) and in a control village without plantations (Ayébo). Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423992PMC
May 2019
1 Read

Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999-2016.

Trop Med Health 2019 15;47:20. Epub 2019 Mar 15.

Niue Health Department, Alofi, Niue.

Background: Lymphatic filariasis (LF) is a mosquito-borne parasitic disease which is targeted for elimination as a public health problem worldwide. Niue is a small self-governing South Pacific island nation with approximately 1600 residents that was formerly LF endemic. Here, we review the progress made towards eliminating LF in Niue since 1999. Read More

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http://dx.doi.org/10.1186/s41182-019-0141-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420762PMC
March 2019
1 Read

Profiling the best-performing community medicine distributors for mass drug administration: a comprehensive, data-driven analysis of treatment for schistosomiasis, lymphatic filariasis, and soil-transmitted helminths in Uganda.

BMC Med 2019 Mar 28;17(1):69. Epub 2019 Mar 28.

Vector Control Division, Bilharzia and Worm Control Programme, Uganda Ministry of Health, Kampala, Uganda.

Background: The most prevalent neglected tropical diseases are treated through blanket drug distribution that is reliant on lay community medicine distributors (CMDs). Yet, treatment rates achieved by CMDs vary widely and it is not known which CMDs treat the most people.

Methods: In Mayuge District, Uganda, we tracked 6779 individuals (aged 1+ years) in 1238 households across 31 villages. Read More

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http://dx.doi.org/10.1186/s12916-019-1303-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437990PMC
March 2019
1 Read

Using intervention mapping to design and implement quality improvement strategies towards elimination of lymphatic filariasis in Northern Ghana.

PLoS Negl Trop Dis 2019 03 25;13(3):e0007267. Epub 2019 Mar 25.

Public Health Leadership Program, Gillings School of Global Public Health, University of North Carolina, McGavran-Greenberg Hall, Chapel Hill, North Carolina, United State of America.

Introduction: The Global Strategy to Eliminate Lymphatic Filiariasis (GFELF) through Mass Drug Administration (MDA) has been implemented in Ghana since the year 2000 and transmission has been interrupted in 76 of 98 endemic districts. To improve the MDA in the remaining districts with microfilaria (MF) prevalence above the 1% threshold for the interruption of transmission, there is a need to identify and implement appropriate quality improvement (QI) strategies. This paper describes the use of intervention mapping to select QI strategies to improve an existing evidence-based MDA program in Northern Ghana. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448919PMC
March 2019
1 Read

Identification and classification of differentially expressed genes in pyrethroid-resistant Culex pipiens pallens.

Mol Genet Genomics 2019 Mar 23. Epub 2019 Mar 23.

Department of Pathogen Biology, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, People's Republic of China.

Culex pipiens pallens is an important vector that transmits Bancroftian filariasis, Japanese encephalitis and other diseases that pose a serious threat to human health. Extensive and improper use of insecticides has caused insecticide resistance in mosquitoes, which has become an important obstacle to the control of mosquito-borne diseases. It is crucial to investigate the underlying mechanism of insecticide resistance. Read More

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http://dx.doi.org/10.1007/s00438-018-1521-7DOI Listing
March 2019
1 Read

A Simple Genotyping Method for Rapid Differentiation of Subtypes and Subtype Distribution of spp. in Thailand.

Pathogens 2019 Mar 21;8(1). Epub 2019 Mar 21.

Lymphatic Filariasis and Tropical Medicine Research Unit, Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

spp. is one of the most common protozoa of humans and animals worldwide. The genetic diversity of spp. Read More

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http://dx.doi.org/10.3390/pathogens8010038DOI Listing
March 2019
2 Reads

A detailed review of the mosquitoes (Diptera: Culicidae) of Iran and their medical and veterinary importance.

Acta Trop 2019 Mar 18;194:106-122. Epub 2019 Mar 18.

Department of Life Sciences, Natural History Museum, London, UK.

Mosquitoes (Diptera: Culicidae) are the most significant arthropods of medical importance because of the burden of diseases, such as malaria, encephalitis and filariasis, which are caused by pathogens and parasites they transmit to humans. In 2007, the most recently published checklist of Iranian mosquitoes included 64 species representing seven genera. Public databases were searched to the end of August 2018 for publications concerning the diseases in Iran caused by mosquito-borne pathogens. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.03.019DOI Listing
March 2019
1 Read

Microfilaria: not always associated with eosinophilia.

Trop Doct 2019 Mar 21:49475519833264. Epub 2019 Mar 21.

2 Professor, Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Filariasis is a parasitic infection seen predominantly in tropical and subtropical countries including India. In clinically suspected cases, examining a thick wet mount smear or a buffy coat film is most informative. In unsuspected cases, however, eosinophilia in a peripheral blood smear (PBS) may be the sole indicator of parasitaemia. Read More

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http://dx.doi.org/10.1177/0049475519833264DOI Listing

Impact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in Cameroon.

Parasit Vectors 2019 Mar 19;12(1):114. Epub 2019 Mar 19.

Global Health Institute, University of Antwerp, Antwerp, Belgium.

Background: Surveys conducted in 1991-1992 in the Mbam Valley (Cameroon) revealed that onchocerciasis was highly endemic, with community microfilarial loads (CMFL) > 100 microfilariae/snip in some villages. Also in 1991-1992, a survey of suspected cases of epilepsy (SCE) found 746 SCE using a questionnaire administered to individuals identified by key informants, with prevalences reaching 13.6% in some communities. Read More

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http://dx.doi.org/10.1186/s13071-019-3345-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423875PMC
March 2019
1 Read

Assessing the Presence of Infections in Vectors Using Xenomonitoring in Lymphatic Filariasis Endemic Districts in Ghana.

Trop Med Infect Dis 2019 Mar 17;4(1). Epub 2019 Mar 17.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581 Legon, Ghana.

Mass drug administration (MDA) is the current mainstay to interrupt the transmission of lymphatic filariasis. To monitor whether MDA is effective and transmission of lymphatic filariasis indeed has been interrupted, rigorous surveillance is required. Assessment of transmission by programme managers is usually done via serology. Read More

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http://dx.doi.org/10.3390/tropicalmed4010049DOI Listing

Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area.

PLoS One 2019 18;14(3):e0213686. Epub 2019 Mar 18.

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Malaria reduction and future elimination in China is made more difficult by the importation of cases from neighboring endemic countries, particularly Myanmar, Laos, and Vietnam, and increased travel to Africa by Chinese nationals. The increasing prevalence of artemisinin resistant parasites across Southeast Asia highlights the importance of monitoring the parasite importation into China. Artemisinin resistance in the Mekong region is associated with variants of genes encoding the K13 kelch domain protein (pf13k), found in specific genetic backgrounds, including certain alleles of genes encoding the chloroquine resistance transporter (pfcrt) and multidrug resistance transporter PgH1 (pfmdr1). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422288PMC
March 2019
3 Reads

Community and Drug Distributor Perceptions and Experiences of Mass Drug Administration for the Elimination of Lymphatic Filariasis: A Rapid Review of Qualitative Research.

Adv Parasitol 2019 16;103:117-149. Epub 2018 Oct 16.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

Study Objectives: This article presents findings from a rapid review of qualitative research conducted to inform decision makers about community and drug distributor perceptions and experiences of mass drug administration campaigns for the elimination of lymphatic filariasis. We focused on questions related to acceptability of the mass drug administration campaigns within these groups and their thoughts around the feasibility of planning and carrying out the campaigns.

Methods: We carried out a systematic search in five databases to identify potential studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0065308X183005
Publisher Site
http://dx.doi.org/10.1016/bs.apar.2018.09.003DOI Listing
October 2018
3 Reads

Neglected tropical diseases: elimination and eradication.

Clin Med (Lond) 2019 Mar;19(2):157-160

London School of Hygiene and Tropical Medicine, London, UK.

The term neglected tropical diseases (NTDs) describes a disparate group of diseases which affect populations living in poverty and are important causes of morbidity and mortality worldwide. Global programmes for the control of NTDs benefit large-scale donations made by pharmaceutical companies. A number of NTDs have internationally agreed targets for their control, elimination and eradication. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-2-157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454364PMC

Preclinical development of an oral anti- macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.

Sci Transl Med 2019 Mar;11(483)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin A, was identified as a hit against This bacterial endosymbiont is required for filarial worm viability and fertility and is a validated target for macrofilaricidal drugs. Medicinal chemistry was undertaken to develop tylosin A analogs with improved oral bioavailability. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau2086DOI Listing
March 2019
3 Reads
15.843 Impact Factor

The Effect of a Regimen of Antifungal Cream Use on Episodes of Acute Adenolymphangitis (ADL) among Lymphedema Patients: An Application Using Marginal Structural Models.

J Epidemiol Glob Health 2018 Dec;8(3-4):176-182

Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, MS A-06, Atlanta, GA 30329-4027, United States.

Episodes of adenolymphangitis (ADL) are a recurrent clinical aspect of lymphatic filariasis (LF) and a risk factor for progression of lymphedema. Inter-digital entry lesions, often found on the web spaces between the toes of those suffering from lymphedema, have been shown to contribute to the occurrence of ADL episodes. Use of antifungal cream on lesions is often promoted as a critical component of lymphedema management. Read More

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http://dx.doi.org/10.2991/j.jegh.2017.10.009DOI Listing
December 2018
1 Read

Loa loa microfilariae in skin snips: consequences for onchocerciasis monitoring and evaluation in L. loa endemic areas.

Clin Infect Dis 2019 Mar 6. Epub 2019 Mar 6.

Centre for Research on Filariasis and other Tropical Diseases, Yaounde Cameroon.

The specificity of skin snips for onchocerciasis diagnosis is considered to be almost 100%. In this study, molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz172DOI Listing
March 2019
12 Reads
8.886 Impact Factor

Investigation of Mixture Modelling Algorithms as a Tool for Determining the Statistical Likelihood of Serological Exposure to Filariasis Utilizing Historical Data from the Lymphatic Filariasis Surveillance Program in Vanuatu.

Trop Med Infect Dis 2019 Mar 8;4(1). Epub 2019 Mar 8.

College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4878, Australia.

As the prevalence of lymphatic filariasis declines, it becomes crucial to adequately eliminate residual areas of endemicity and implement surveillance. To this end, serological assays have been developed, including the Bm14 Filariasis CELISA which recommends a specific optical density cut-off level. We used mixture modelling to assess positive cut-offs of Bm14 serology in children in Vanuatu using historical OD (Optical Density) ELISA values collected from a transmission assessment survey (2005) and a targeted child survey (2008). Read More

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https://www.mdpi.com/2414-6366/4/1/45
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http://dx.doi.org/10.3390/tropicalmed4010045DOI Listing
March 2019
5 Reads

Evaluation of Pistia stratiotes fractions as effective larvicide against Anopheles mosquitoes.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):945-950

c Department of Biological Sciences , Bayero University , Kano , Nigeria.

Mosquito are well-known vectors that cause diseases particularly malaria and filariasis which are detrimental to human health. These vectors occur mainly in tropical countries where more than 2 billion people live in endemic regions with about one million deaths been claimed yearly from malaria and filariasis. The study is aimed at evaluating the larvicidal activity of Pistia stratiotes fractions on Anopheles mosquitoes (Diptera: Culicidae). Read More

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http://dx.doi.org/10.1080/21691401.2019.1582538DOI Listing
December 2019

Mapping of lymphatic filariasis in loiasis areas: A new strategy shows no evidence for Wuchereria bancrofti endemicity in Cameroon.

PLoS Negl Trop Dis 2019 03 8;13(3):e0007192. Epub 2019 Mar 8.

Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Background: Mapping of lymphatic filariasis (LF) caused by Wuchereria bancrofti largely relies on the detection of circulating antigen using ICT cards. Several studies have recently shown that this test can be cross-reactive with sera of subjects heavily infected with Loa loa and thus mapping results in loiasis endemic areas may be inaccurate.

Methodology/principal Findings: In order to develop an LF mapping strategy for areas with high loiasis prevalence, we collected day blood samples from 5,001 subjects residing in 50 villages that make up 6 health districts throughout Cameroon. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436748PMC
March 2019
132 Reads

Immunological evaluation of fusion protein of abundant larval protein transcript-2 (BmALT-2) and Tuftsin in experimental mice model.

Parasite Epidemiol Control 2019 Feb 7;4:e00092. Epub 2019 Feb 7.

Centre for Biotechnology, Anna University, Sardar Patel Road, Guindy, Chennai 600025, Tamil Nadu, India.

Introduction: Filariasis, a neglected tropical helminth disease needs vaccine besides mass drug administration for its successful eradication.

Methods: An attempt was made to produce a fusion protein (P-TUFT-ALT-2) of abundant larval transcript protein-2 and Tuftsin to enhance its immunogenicity. The fusion construct was expressed in , a nonexpensive commercial expression system. Read More

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http://dx.doi.org/10.1016/j.parepi.2019.e00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378782PMC
February 2019

Gender equity in mass drug administration for neglected tropical diseases: data from 16 countries.

Int Health 2019 Mar 8. Epub 2019 Mar 8.

RTI International, 701 13th St NW, Suite 750, Washington, DC USA.

Background: Gender equity in global health is a target of the Sustainable Development Goals and a requirement of just societies. Substantial progress has been made towards control and elimination of neglected tropical diseases (NTDs) via mass drug administration (MDA). However, little is known about whether MDA coverage is equitable. Read More

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http://dx.doi.org/10.1093/inthealth/ihz012DOI Listing

Epidemiological Features of Highly Pathogenic Avian Influenza in Cameroon.

Vet Med Int 2019 27;2019:3796369. Epub 2019 Jan 27.

Unit of Veterinary Public Health and Clinical Sciences, Faculty of Veterinary Medicine, Universite des Montagnes, Cameroon.

The epidemiology of avian influenza is unknown in Cameroon despite the two outbreaks that occurred in 2006 and 2016-2017, respectively. In order to fill the gap, an attempt was made to provide some basic information on the epidemiology of highly pathogenic avian influenza in Cameroon. Thus, data were collected from follow-up reports of the second HPAI outbreaks prepared by the veterinary health officials of Cameroon and sent to the World Organisation for Animal Health (OIE). Read More

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http://dx.doi.org/10.1155/2019/3796369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369508PMC
January 2019
1 Read

The Global Burden of Disease of Zoonotic Parasitic Diseases: Top 5 Contenders for Priority Consideration.

Authors:
Konrad Pisarski

Trop Med Infect Dis 2019 Mar 2;4(1). Epub 2019 Mar 2.

Division of Tropical Health & Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4814, Australia.

With the rise of global migration, international trade, and global environmental challenges such as climate change, it is not surprising that the interactions between humans and other animals are shifting. Salient infectious diseases, such as malaria and HIV (which have high burdens of disease), attract sophisticated public health frameworks and funding from global/regional organisations, such as the WHO. This unfortunately detracts attention from the many emerging zoonoses that fall under the radar as neglected tropical diseases (NTDs). Read More

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http://dx.doi.org/10.3390/tropicalmed4010044DOI Listing

Exploring the Insecticidal Potential of Boldo () Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean .

Molecules 2019 Mar 1;24(5). Epub 2019 Mar 1.

School of Pharmacy, University of Camerino, Via S. Agostino 1, 62032 Camerino Italy.

Every year Chile exports about 2000 tons of boldo folium (), which is used around the world as a traditional herbal medicinal product (THMP), mostly to relieve gastrointestinal disorders. This biomass may be a resource for the agrochemical industry to manufacture botanical insecticides. In this regard, the insecticidal potential of boldo has been poorly investigated. Read More

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http://dx.doi.org/10.3390/molecules24050879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429277PMC
March 2019
6 Reads

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

PLoS Negl Trop Dis 2019 02 28;13(2):e0007159. Epub 2019 Feb 28.

Global Pharmaceutical Research and Development, AbbVie, North Chicago, Illinois, United States of America.

There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administration (MDA) with current microfilaricides, and to provide a solution to treatment of onchocerciasis / loiasis co-infection, where MDA is restricted. We have identified a novel macrofilaricidal agent, Tylosin A (TylA), which acts by targeting the worm-symbiont Wolbachia bacterium. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413952PMC
February 2019
5 Reads

"The sun keeps rising but darkness surrounds us": a qualitative exploration of the lived experiences of women with obstetric fistula in Ethiopia.

BMC Womens Health 2019 Feb 26;19(1):37. Epub 2019 Feb 26.

Department of Health, Behavior and Society, Institute of Health, Jimma University, PO.Box: 378, Jimma, Ethiopia.

Background: Obstetric fistula is a hole between the vagina and bladder, and/or between the vagina and rectum, triggered by prolonged obstructed labor. The World Health Organization has estimated that at least 50,000 to 100,000 cases of obstetric fistula occur every year, and that over two million women with obstetric fistula in developing countries remain untreated. Research on women's lived experiences of obstetric fistula is limited. Read More

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http://dx.doi.org/10.1186/s12905-019-0732-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390300PMC
February 2019
7 Reads

Bridging the gap in outreach and compliance with mass drug administration for lymphatic filariasis elimination in an endemic district in Kerala, India: an intervention research approach.

Health Educ Res 2019 Feb 25. Epub 2019 Feb 25.

Vector Control Research Centre, (Indian Council of Medical Research), Medical Complex, Indira Nagar, Pondicherry, India.

Lymphatic filariasis (LF), a neglected tropical disease is targeted for elimination globally by 2020. National Health Policy of India set the goal by 2017 and annual single-dose mass drug administration (MDA) with anti-filarial drugs is in operation in endemic districts since 2004. Performance and effectiveness of MDA was diverse across the nation and prevalence of infection continues above threshold level in 50% of endemic districts which requires alternative strategies. Read More

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http://dx.doi.org/10.1093/her/cyz005DOI Listing
February 2019
1 Read

Comparison of Staging Systems to Assess Lymphedema Caused by Cancer Therapies, Lymphatic Filariasis, and Podoconiosis.

Lymphat Res Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Tropical Disease Biology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Lymphedema is a disease of the skin and subcutaneous tissue resulting from a disturbance in lymph flow. Anyone can be affected, and causes include cancer therapy when lymph nodes are removed or irradiated, the parasitic disease lymphatic filariasis, and damage caused by exposure to irritant soils known as podoconiosis. Manifest lymphedema is progressive and a major contributor to disability, stigma, and social isolation for affected people. Read More

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http://dx.doi.org/10.1089/lrb.2018.0063DOI Listing
February 2019
1 Read