16,698 results match your criteria Filariasis


The Experimental Infections of the Human Isolate of Strongyloides Stercoralis in a Rodent Model (The Mongolian Gerbil, Meriones Unguiculatus).

Pathogens 2019 Feb 5;8(1). Epub 2019 Feb 5.

Lymphatic Filariasis and Tropical Medicine Research Unit, Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Strongyloidiasis is life-threatening disease which is mainly caused by infection. Autoinfection of the parasite results in long-lasting infection and fatal conditions, hyperinfection and dissemination (primarily in immunosuppressed hosts). However, mechanisms of autoinfection and biology remain largely unknown. Read More

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http://dx.doi.org/10.3390/pathogens8010021DOI Listing
February 2019

[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax].

Bull Soc Pathol Exot 2018 ;111(1):17-23

Direction d'épidémiologie, de laboratoire et de recherches, 52 angle Delmas 33 et rue Charbonnières, Port-au-Prince, Haïti.

Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Read More

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http://dx.doi.org/10.3166/bspe-2018-0005DOI Listing
January 2018

Management of vulvar lymphedema of filarial origin in a pregnant woman and its outcome: A case report.

J Obstet Gynaecol Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynaecology, Jawaharlal Nehru Institute of Post Graduate Education and Research, Pondicherry, India.

Lymphedema of filarial origin affecting the vulva is extremely rare. It is a dilemma if seen in a pregnant woman as there are no guidelines regarding excision and the mode of delivery. With the World Health Organization-driven global program to eradicate filaria, it is unfortunate to see such cases. Read More

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http://dx.doi.org/10.1111/jog.13933DOI Listing
February 2019

Prevalence and intensity of Loa loa infection over twenty-three years in three communities of the Mbalmayo health district (Central Cameroon).

BMC Infect Dis 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Centre for Research on Filariasis and other Tropical Diseases, PO Box 5797, Yaounde, Cameroon.

Background: Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the second or third most common reason for medical consultation after malaria, and a recent study has reported an excess mortality associated with the infection. However, the clinical impact of this filarial disease is yet to be elucidated, and it is still considered a benign disease eliciting very little attention. Read More

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http://dx.doi.org/10.1186/s12879-019-3776-yDOI Listing
February 2019
1 Read

Residual Efficacy of Insecticides Sprayed on Different Types of Surfaces Against Leishmaniasis and Filariasis Vectors in Egypt.

J Med Entomol 2019 Feb 9. Epub 2019 Feb 9.

Entomology Branch, Walter Reed Army Institute of Research, Silver Spring, Silver Spring, MD.

Determination of the residual activity of insecticides is an essential component in the selection of an appropriate insecticide for indoor residual spraying operations. This report presents the results of a laboratory study to evaluate the residual bio-efficacy of four insecticides sprayed on the most common house-wall surfaces that occur in Egypt (wood, mud, and cement) against Phlebotomus papatasi (Scopoli, 1786) (Diptera: Psychodidae) and Culex pipiens Linnaeus, 1758 (Diptera: Culicidae). In total, 28,050 P. Read More

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http://dx.doi.org/10.1093/jme/tjy243DOI Listing
February 2019

Cytochrome P450 Mono-Oxygenase and Resistance Phenotype in DDT and Deltamethrin-Resistant Anopheles gambiae (Diptera: Culicidae) and Culex quinquefasciatus in Kosofe, Lagos, Nigeria.

J Med Entomol 2019 Feb 11. Epub 2019 Feb 11.

Vector Research Laboratory, Nigeria Institute of Medical Research, Lagos, Nigeria.

Pyrethroids and DDT are key insecticides in the control of malaria, yellow fever, and lymphatic filariasis vectors. Knockdown and metabolic resistance mechanisms have been proven to be important in determining the efficacy of insecticides. Here we investigated cytochrome P450 as a resistance mechanism in Anopheles gambiae Giles and Culex quinquefasciatus Say exposed to deltamethrin and DDT. Read More

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https://academic.oup.com/jme/advance-article/doi/10.1093/jme
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http://dx.doi.org/10.1093/jme/tjz006DOI Listing
February 2019
2 Reads

First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions.

Parasitol Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wangland Road, Bangkoknoi, Bangkok, 10700, Thailand.

Lymphatic filariae are important human and animal parasites. Infection by these parasites could lead to severe morbidity and has significant socioeconomic impacts. Topical selamectin is a semi-synthetic macrocyclic lactone that is widely used to prevent heartworm infection. Read More

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http://link.springer.com/10.1007/s00436-019-06248-3
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http://dx.doi.org/10.1007/s00436-019-06248-3DOI Listing
February 2019
1 Read

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

J Med Chem 2019 Feb 7. Epub 2019 Feb 7.

A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found to be potent anti-Wolbachia antibiotics, and as such, may be useful in the treatment of filarial infections caused by Onchocherca volvulus, resulting in Onchocerciasis or river blindness, or Wuchereria bancrofti and Brugia malayi and related parasitic nematodes resulting in lymphatic filariasis. These two important Neglected Tropical diseases (NTDs) disproportionately impact patients in the developing world. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01854DOI Listing
February 2019

Molecular identification of Wolbachia and Sodalis glossinidius in the midgut of Glossina fuscipes quanzensis from the Democratic Republic of Congo.

Parasite 2019 7;26. Epub 2019 Feb 7.

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, PO Box 812 Yaoundé, Cameroon.

During the last 30 years, investigations on the microbiome of different tsetse species have generated substantial data on the bacterial flora of these cyclical vectors of African trypanosomes, with the overarching goal of improving the control of trypanosomiases. It is in this context that the presence of Wolbachia and Sodalis glossinidius was studied in wild populations of Glossina fuscipes quanzensis from the Democratic Republic of Congo. Tsetse flies were captured with pyramidal traps. Read More

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http://dx.doi.org/10.1051/parasite/2019005DOI Listing
February 2019
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Environmental factors associated with the distribution of Loa loa vectors Chrysops spp. in Central and West Africa: seeing the forest for the trees.

Parasit Vectors 2019 Feb 6;12(1):72. Epub 2019 Feb 6.

Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.

Background: Loiasis is caused by the filarial parasite Loa loa, which is widespread through Central and West Africa and largely confined the tropical equatorial rainforests. The tabanid flies Chrysops silacea and Chrysops dimidiata are the main vectors driving transmission. This study aimed to better define the spatial distribution and ecological niche of the two vectors to help define spatial-temporal risk and target appropriate, timely intervention strategies for filariasis control and elimination programmes. Read More

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http://dx.doi.org/10.1186/s13071-019-3327-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366063PMC
February 2019

Non-compliance to mass drug administration associated with the low perception of the community members about their susceptibility to lymphatic filariasis in Ankobra, Ghana.

Infect Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

School of Public Health (SPH), University of Ghana, Legon, Accra. Ghana.

Background: Lymphatic filariasis (LF) is a parasitic disease that has been targeted for elimination through the Mass Drug Administration (MDA.) Although the MDA started in the Ankobra community in Ghana in 2000, LF prevalence as reported in 2014 was relatively high (4.5%). Read More

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http://dx.doi.org/10.2174/1871526519666190206210808DOI Listing
February 2019

Potential factors influencing lymphatic filariasis transmission in "hotspot" and "control" areas in Ghana: the importance of vectors.

Infect Dis Poverty 2019 Feb 5;8(1). Epub 2019 Feb 5.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

Background: Mass drug administration (MDA) programmes for the control of lymphatic filariasis in Ghana, have been ongoing in some endemic districts for 16 years. The current study aimed to assess factors that govern the success of MDA programmes for breaking transmission of lymphatic filariasis in Ghana.

Methods: The study was undertaken in two "hotspot" districts (Ahanta West and Kassena Nankana West) and two control districts (Mpohor and Bongo) in Ghana. Read More

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http://dx.doi.org/10.1186/s40249-019-0520-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362603PMC
February 2019

Plant extracts for developing mosquito larvicides: from laboratory to the field, with insights on the modes of action.

Acta Trop 2019 Jan 31. Epub 2019 Jan 31.

Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy. Electronic address:

In the last decades, major research efforts have been done to investigate the insecticidal activity of plant-based products against mosquitoes. This is a modern and timely challenge in parasitology, aimed to reduce the frequent overuse of synthetic pesticides boosting resistance development in mosquitoes and causing serious threats to human health and environment. This review covers the huge amount of literature available on plant extracts tested as mosquito larvicides, particularly aqueous and alcoholic ones, due to their easy formulation in water without using surfactants. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.019DOI Listing
January 2019
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Preventive chemotherapy reverses covert, lymphatic associated tissue change in young people with lymphatic filariasis in Myanmar.

Trop Med Int Health 2019 Jan 31. Epub 2019 Jan 31.

Centre for Neglected Tropical Diseases, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Objectives: This longitudinal comparative study investigated the effect of preventive chemotherapy (PC) on covert tissue changes associated with lymphatic filariasis (LF) among young people living in an LF-endemic area in Myanmar.

Methods: Tissue compressibility and extracellular free fluid in the lower limbs of people aged 10 - 21 years were measured using Indurometry and bio-impedance spectroscopy (BIS). Baseline measures were taken in October 2014, annual mass drug administration (MDA) of PC was delivered in December and in March 2015, and further PC was offered to LF-positive cases who had missed MDA. Read More

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http://doi.wiley.com/10.1111/tmi.13212
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http://dx.doi.org/10.1111/tmi.13212DOI Listing
January 2019
3 Reads

Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test.

PLoS Negl Trop Dis 2019 Jan 30;13(1):e0007064. Epub 2019 Jan 30.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States of America.

Background: Mali has become increasingly interested in the evaluation of transmission of both Wuchereria bancrofti and Onchocerca volvulus as prevalences of both infections move toward their respective elimination targets. The SD Bioline Onchocerciasis/LF IgG4 Rapid Test was used in 2 evaluation units (EU) to assess its performance as an integrated surveillance tool for elimination of lymphatic filariasis (LF) and onchocerciasis.

Methodology/principal Findings: A cross sectional survey with SD Bioline Onchocerciasis/LF IgG4 Rapid Test was piggy-backed onto a transmission assessment survey (TAS) (using the immunochromatographic card test (ICT) Binax Filariasis Now test for filarial adult circulating antigen (CFA) detection) for LF in Mali among 6-7 year old children in 2016 as part of the TAS in two EUs namely Kadiolo-Kolondieba in the region of Sikasso and Bafoulabe -Kita-Oussoubidiagna-Yelimane in the region of Kayes. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007064
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http://dx.doi.org/10.1371/journal.pntd.0007064DOI Listing
January 2019
6 Reads

Subcutaneous filariasis: An unusual presentation with an adult gravid worm on aspiration.

Trop Parasitol 2018 Jul-Dec;8(2):121-123. Epub 2018 Dec 27.

Department of Pathology, ESI Hospital, Rohini, Delhi, India.

Detection of adult gravid filarial worm in fine-needle aspiration cytology (FNAC) smears is unusual despite the high incidence of this parasite in endemic zones. Bancroftian filariasis presenting as subcutaneous nodules is very rare, and only a few cases are reported in literature. In spite of various reports stating the presence of microfilaria using aspiration cytology in various sites, the presence of an adult gravid filarial worm in subcutaneous nodules by FNAC is an extremely rare finding. Read More

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http://dx.doi.org/10.4103/tp.TP_60_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329263PMC
December 2018
1 Read

Breast ductal carcinoma with coexistent microfilaria: Diagnosed on cytology.

Trop Parasitol 2018 Jul-Dec;8(2):103-105. Epub 2018 Dec 27.

Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India.

Filariasis is a major health problem of the tropical and subtropical regions, but filariae are also found in temperate climates. The disease is endemic all over India and microfilariae have been observed as coincidental findings with inflammatory conditions and neoplastic lesions. We report a rare case of a 40-year-old female from a nonendemic area presenting with lump in the left breast. Read More

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http://dx.doi.org/10.4103/tp.TP_34_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329269PMC
December 2018
1 Read

Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study.

Parasit Vectors 2019 Jan 28;12(1):64. Epub 2019 Jan 28.

University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Background: Vector-borne pathogens are emerging concerns in multiple regions of Canada. Determining regional prevalence of canine vector-borne pathogens and documenting change will improve clinician awareness, enable targeted prevention, enhance diagnosis and ideally reduce the risk of disease. Study objectives were to: (i) estimate the prevalence of positive canine vector-borne test results from samples submitted in Canada; (ii) assess change in prevalence over time, from baseline (2008) to 2015; and (iii) estimate the prevalence of pathogen co-infections. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-019-3299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350403PMC
January 2019
5 Reads

Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23.

Parasit Vectors 2019 Jan 28;12(1):63. Epub 2019 Jan 28.

Janssen Diagnostics, Janssen R&D, Turnhoutseweg 30, 2340, Beerse, Belgium.

Background: Ov16 serology is considered a reference method for Onchocerca volvulus epidemiological mapping. Given the suboptimal sensitivity of this test and the fact that seroconversion takes more than a year after infection, additional serological tests might be needed to guide onchocerciasis elimination programmes. Recently, two linear epitopes encoded in OvMP-1 and OvMP-23 peptides were introduced as serological markers, but the observed antibody cross-reactivity in samples originating from Onchocerca volvulus non-endemic areas required further investigation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350367PMC
January 2019
8 Reads

Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation.

Chemosphere 2019 Jan 21;222:56-61. Epub 2019 Jan 21.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key Laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, Shanghai 200025, China; Jiangsu Academy of Agricultural Sciences, Jiangsu 210014, China; The Institute of Microbiology of the Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Schistosomiasis japonica caused by Schistosoma japonicum infection is recognized as a considerable economic and public health concern in Asia. Oncomelania hupensis is the sole intermediate host of S. japonicum. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.102DOI Listing
January 2019
1 Read

Microbial exopolymer-capped selenium nanowires - Towards new antibacterial, antibiofilm and arbovirus vector larvicides?

J Photochem Photobiol B 2019 Jan 18;192:55-67. Epub 2019 Jan 18.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Arboviral diseases and microbial pathogens resistant to commercially available drugs are on the rise. Herein, a facile microbial-based approach was developed to synthesize selenium nanowires (Se NWs) using microbial exopolymer (MEP) extracted from the Bacillus licheniformis (probiotic bacteria). MEP-Se NWs were characterized using UV-Visible, XRD, FTIR, HR-TEM, FE-SEM and EDX. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.01.009DOI Listing
January 2019
3 Reads

Corrigendum to "RNA interference in vivo in Schistosoma japonicum: Establishing and optimization of RNAi mediated suppression of gene expression by long dsRNA in the intra-mammalian life stages of worms" [Biochem. Biophys. Res. Commun. 503 (2018) 1004-1010].

Biochem Biophys Res Commun 2019 Feb 21;510(1):85. Epub 2019 Jan 21.

State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China; Key Laboratory of Parasite and Vector Biology of the Chinese Ministry of Health, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.01.051DOI Listing
February 2019
1 Read

Elimination of lymphatic filariasis in South East Asia.

BMJ 2019 Jan 22;364:k5198. Epub 2019 Jan 22.

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Germany.

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http://dx.doi.org/10.1136/bmj.k5198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340355PMC
January 2019

Submicroscopic Malaria in Migrants from Sub-Saharan Africa, Spain.

Emerg Infect Dis 2019 Feb;25(2):349-352

In a screening program, we detected submicroscopic malaria in 8.9% of recent migrants to Spain from sub-Saharan Africa. Hemoglobinopathies and filarial infection occurred more frequently in newly arrived migrants with submicroscopic malaria than in those without. Read More

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http://dx.doi.org/10.3201/eid2502.180717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346455PMC
February 2019

Epidemiological screening and xenomonitoring for human lymphatic filariasis infection in select districts in the states of Maharashtra and Karnataka, India.

Parasitol Res 2019 Jan 21. Epub 2019 Jan 21.

Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, USA.

Lymphatic filariasis (LF) is a mosquito-transmitted tropical neglected parasitic infection that currently affects over 120 million people around the world and another 856 million people are at risk of acquiring the infection. Mass Drug Administration (MDA) spearheaded by the World Health Organization is the only current strategy to control this infection in endemic areas. In this study, we performed an epidemiological survey in select regions in the southern parts of India to determine the current status of LF infection in subjects. Read More

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http://dx.doi.org/10.1007/s00436-019-06205-0DOI Listing
January 2019

Flubendazole as a macrofilaricide: History and background.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006436. Epub 2019 Jan 16.

Johnson & Johnson Global Public Health, Janssen Research and Development, LLC., New Brunswick, New Jersey, United States of America.

Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lead to high macrofilaricidal efficacy in a variety of preclinical models and in humans. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334891PMC
January 2019
5 Reads

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006320. Epub 2019 Jan 16.

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.

Flubendazole (FBZ) is highly efficacious against filarial nematodes after parenteral administration and presents a promising macrofilaricidal drug candidate for the elimination of onchocerciasis and other filariae. In the present study the efficacy of a newly developed bioavailable amorphous solid dispersion (ASD) oral formulation of FBZ was investigated in the Litomosoides sigmodontis jird model. FBZ was administered to chronically infected, microfilariae-positive jirds by single (40mg/kg), repeated (2, 6 or 15mg/kg for 5 or 10 days) oral (OR) doses or single subcutaneous (SC) injections (2 or 10mg/kg). Read More

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http://dx.doi.org/10.1371/journal.pntd.0006320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334906PMC
January 2019
2 Reads

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006787. Epub 2019 Jan 16.

Dept. of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.

River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms can live for several years, releasing millions of microfilariae throughout the course of infection. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334909PMC
January 2019
1 Read

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006356. Epub 2019 Jan 16.

Department of Parasitology and Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-cutaneous (s.c. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334903PMC
January 2019
1 Read

Entomological assessment of the transmission following recrudescence of onchocerciasis in the Comoé Valley, Burkina Faso.

Parasit Vectors 2019 Jan 15;12(1):34. Epub 2019 Jan 15.

Ministère de l'Enseignement Supérieur, de la Recherche Scientifique et de l'Innovation, Institut de Recherche en Sciences de la Santé (IRSS), Direction Régionale de l'Ouest, BP 545, Bobo Dioulasso 01, Burkina Faso.

Background: Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite the decade-long West African Regional Programme for the Elimination of Onchocerciasis, involving the mass administration of ivermectin to populations in endemic areas, recrudescence has occurred. An example is in the Cascades Region of south-west Burkina Faso where the resumption of transmission had resulted in infection prevalences of up to 70% in some villages. Read More

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http://dx.doi.org/10.1186/s13071-019-3290-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332526PMC
January 2019
1 Read

Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast.

Parasite 2019 15;26. Epub 2019 Jan 15.

Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov First Moscow State Medical University, Moscow 119435, Russia.

Dirofilariasis is endemic in Russia, as well as in many other European countries. The aim of this study was to assess the ability of mosquitoes to transfer Dirofilaria immitis and Dirofilaria repens in regions with temperate and subtropical climates. The possible impact of the symbiotic bacterium Wolbachia on Dirofilaria transmission was also investigated. Read More

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https://www.parasite-journal.org/10.1051/parasite/2019002
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http://dx.doi.org/10.1051/parasite/2019002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333102PMC
January 2019
7 Reads

The central adaptor molecule TRIF influences L. sigmodontis worm development.

Parasitol Res 2019 Feb 15;118(2):539-549. Epub 2019 Jan 15.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.

Worldwide approximately 68 million people are infected with lymphatic filariasis (Lf), provoked by Wuchereria bancrofti, Brugia malayi and Brugia timori. This disease can lead to massive swelling of the limbs (elephantiasis) and disfigurement of the male genitalia (hydrocele). Filarial induced immune regulation is characterised by dominant type 2 helper T cell and regulatory immune responses. Read More

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http://dx.doi.org/10.1007/s00436-018-6159-1DOI Listing
February 2019
1 Read

Larvicidal Activity of Synthesized Silver Nanoparticles from Essential Oil against .

Insects 2019 Jan 11;10(1). Epub 2019 Jan 11.

Lymphatic Filariasis and Tropical Medicine Research Unit, Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

is the major vector of the bancroftian filarial parasite which causes human lymphatic filariasis and St. Louis encephalitis. The simple way to stop the transmission is to control the vector by using synthetic chemicals. Read More

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http://www.mdpi.com/2075-4450/10/1/27
Publisher Site
http://dx.doi.org/10.3390/insects10010027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359542PMC
January 2019
6 Reads

New strains of Japanese encephalitis virus circulating in Shanghai, China after a ten-year hiatus in local mosquito surveillance.

Parasit Vectors 2019 Jan 9;12(1):22. Epub 2019 Jan 9.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 20025, People's Republic of China.

Background: Continuous vector pathogen surveillance is essential for preventing outbreaks of mosquito-borne diseases. Several mosquito species acting as vectors of Japanese encephalitis virus (JEV), dengue virus, Zika virus, malaria parasites and other pathogens are primary mosquito species in Shanghai, China. However, few surveys of human pathogenic arboviruses in mosquitoes in Shanghai have been reported in the last ten years. Read More

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http://dx.doi.org/10.1186/s13071-018-3267-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327439PMC
January 2019
3.430 Impact Factor

Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents.

Parasit Vectors 2019 Jan 8;12(1):14. Epub 2019 Jan 8.

Parasites and Vectors Biology Research Unit (PAVBRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Background: Loiasis, an often-neglected tropical disease, is a threat to the success of lymphatic filariasis and onchocerciasis elimination programmes in rainforest areas of the central and western Africa. Its control and even its elimination might be possible through the use of a safe macrofilaricide, a prophylactic drug, or perhaps a vaccine. This present study evaluated the effect of flubendazole (FLBZ) on the development of Loa loa L3 in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s13071-018-3282-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323797PMC
January 2019
7 Reads
3.430 Impact Factor

Albendazole alone or in combination with microfilaricidal drugs for lymphatic filariasis.

Cochrane Database Syst Rev 2019 01 8;1:CD003753. Epub 2019 Jan 8.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA.

Background: The Global Programme to Eliminate Lymphatic Filariasis recommends mass treatment of albendazole co-administered with the microfilaricidal (antifilarial) drugs diethylcarbamazine (DEC) or ivermectin; and recommends albendazole alone in areas where loiasis is endemic.

Objectives: To assess the effects of albendazole alone, and the effects of adding albendazole to DEC or ivermectin, in people and communities with lymphatic filariasis.

Search Methods: We searched the Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Embase (OVID), LILACS (BIREME), and reference lists of included trials. Read More

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http://dx.doi.org/10.1002/14651858.CD003753.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354574PMC
January 2019
1 Read

Prevalence of disease vectors in Lakshadweep Islands during post-monsoon season.

J Vector Borne Dis 2018 Jul-Sep;55(3):189-196

Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu, India.

Background & Objectives: : Increase of vector-borne diseases (VBDs) in India has posed a question on the situation in Lakshadweep Islands, where VBDs are reported from time-to-time. The present investigation was aimed to assess the faunastic situation of the prevailing vectors along with their breeding sites in different islands of the Lakshadweep.

Methods: : Extensive surveys were carried out from November 2017 to January 2018 (post-monsoon season) randomly in the nine inhabited islands of Lakshadweep for conducting faunastic studies on mosquitoes and to know the basic binomics like breeding and resting preference of mosquitoes. Read More

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http://dx.doi.org/10.4103/0972-9062.249127DOI Listing
February 2019

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.

Proc Natl Acad Sci U S A 2019 Jan 7;116(4):1414-1419. Epub 2019 Jan 7.

Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom;

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting >90% of the essential nematode endosymbiont bacterium, , using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. Read More

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http://dx.doi.org/10.1073/pnas.1816585116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347715PMC
January 2019

Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease.

ChemMedChem 2019 Feb 30;14(4):386-453. Epub 2019 Jan 30.

School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa.

The Pathogen Box is a 400-strong collection of drug-like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in-depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure-activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community. Read More

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http://dx.doi.org/10.1002/cmdc.201800755DOI Listing
February 2019

GEOFIL: A spatially-explicit agent-based modelling framework for predicting the long-term transmission dynamics of lymphatic filariasis in American Samoa.

Epidemics 2018 Dec 29. Epub 2018 Dec 29.

Research School of Population Health, The Australian National University, Australia.

In this study, a spatially-explicit agent-based modelling framework GEOFIL was developed to predict lymphatic filariasis (LF) transmission dynamics in American Samoa. GEOFIL included individual-level information on age, gender, disease status, household location, household members, workplace/school location and colleagues/schoolmates at each time step during the simulation. In American Samoa, annual mass drug administration from 2000 to 2006 successfully reduced LF prevalence dramatically. Read More

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http://dx.doi.org/10.1016/j.epidem.2018.12.003DOI Listing
December 2018
3 Reads

Elimination within reach: A cross-sectional study highlighting the factors that contribute to persistent lymphatic filariasis in eight communities in rural Ghana.

PLoS Negl Trop Dis 2019 01 4;13(1):e0006994. Epub 2019 Jan 4.

Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Despite the progress achieved in scaling-up mass drug administration (MDA) for lymphatic filariasis (LF) in Ghana, communities with persistent LF still exist even after 10 years of community treatment. To understand the reasons for persistence, we conducted a study to assess the status of disease elimination and understand the adherence to interventions including MDA and insecticide treated nets.

Methodology And Principal Findings: We conducted a parasitological and epidemiological cross-sectional study in adults from eight villages still under MDA in the Northern Region savannah and the coastal Western Region of the country. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342320PMC
January 2019
1 Read

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.

Nat Commun 2019 01 2;10(1):11. Epub 2019 Jan 2.

Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.

Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of AstraZeneca's 1.3 million in-house compound library and identify 5 novel chemotypes with faster in vitro kill rates (<2 days) than existing anti-Wolbachia drugs that cure onchocerciasis and lymphatic filariasis. Read More

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http://dx.doi.org/10.1038/s41467-018-07826-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315057PMC
January 2019
1 Read
10.742 Impact Factor

Immunogenicity and protective efficacy of Recombinase A from Wolbachia endosymbiont of filarial nematode Brugia malayi (wBmRecA).

Vaccine 2019 Jan 27;37(4):571-580. Epub 2018 Dec 27.

Parasitology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address:

Lymphatic filariasis causes global morbidity. Wolbachia, an endo-symbiotic intracellular bacterium of the filarial nematode helps in their growth and development, regulates fecundity in female worms and contributes to the immunopathogenesis of the disease. However, genes and proteins of Wolbachia that may act as putative vaccine candidates are not known. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.12.015DOI Listing
January 2019
2 Reads

Association of a Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort.

Am J Trop Med Hyg 2019 Feb;100(2):344-350

Centre for Infection Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany.

Lymphatic filariasis (LF) is a parasitic infection, caused by three closely related nematodes, namely , , and . Previously, we have shown that lysate from microfilariae induces the expression of interleukin and programmed death-ligand on monocytes, which lead to inhibition of CD4 T-cell responses. In this study, we investigated associations of and programmed cell death pathway gene polymorphisms with clinical manifestation in LF. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0731
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http://dx.doi.org/10.4269/ajtmh.18-0731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367610PMC
February 2019
6 Reads

Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study.

PLoS Negl Trop Dis 2018 12 27;12(12):e0007002. Epub 2018 Dec 27.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston MA, United States of America.

Background: Neglected tropical diseases (NTDs) account for a large disease burden in sub-Saharan Africa. While the general cost-effectiveness of NTD interventions to improve health outcomes has been assessed, few studies have also accounted for the financial and education gains of investing in NTD control.

Methods: We built on extended cost-effectiveness analysis (ECEA) methods to assess the health gains (e. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007002
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http://dx.doi.org/10.1371/journal.pntd.0007002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307713PMC
December 2018
11 Reads

Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination.

Parasit Vectors 2018 Dec 27;11(1):672. Epub 2018 Dec 27.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

Background: The global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. Read More

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http://dx.doi.org/10.1186/s13071-018-3260-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307201PMC
December 2018
1 Read
3.430 Impact Factor

Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol.

Parasit Vectors 2018 Dec 27;11(1):671. Epub 2018 Dec 27.

College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Background: The American Heartworm Society currently recommends the use of a monthly macrocyclic lactone, a 28-day course of 10 mg/kg doxycycline BID, and the 3-dose protocol of melarsomine dihydrochloride for the treatment of canine heartworm disease. Doxycycline is necessary for the reduction of the bacterium Wolbachia, found in all heartworm life-stages. Previous price increases and decreasing availability prompted us to evaluate alternative tetracycline antibiotics, i. Read More

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http://dx.doi.org/10.1186/s13071-018-3264-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307258PMC
December 2018

Comparative analysis of excretory-secretory antigens of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum regarding their applicability for specific serodiagnosis of human anisakidosis based on IgG-ELISA.

Exp Parasitol 2019 Feb 22;197:9-15. Epub 2018 Dec 22.

Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, 3012, Bern, Switzerland.

Serodiagnosis of human anisakidosis is presently hampered by the current lack of standardised serological assays that allow sensitive and specific detection of Anisakidae-specific antibodies in human patients. In the present study, we comparatively evaluated the diagnostic value (by IgG-ELISA) of excretory-secretory antigens (ESAgs) of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum, representing the most frequently found genera responsible for human infection. In addition, we tested also a mix of the three ES preparations (Mix-ESAgs) as well as two recombinant allergens of A. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144894183035
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http://dx.doi.org/10.1016/j.exppara.2018.12.004DOI Listing
February 2019
10 Reads

Internal Parasites of Pigs and Worm Control Practices in Bamboutos, Western Highlands of Cameroon.

J Parasitol Res 2018 21;2018:8242486. Epub 2018 Nov 21.

Veterinary Research Institute, HAO-Demeter, NAGREF Campus, Thessaloniki, Greece.

Internal parasites are limiting factors to successful, sustainable livestock production. Knowledge on how they are dealt with is important to prevent resistance to anthelmintics. The aim of this study was to describe the internal parasitism of indoor pigs in Bamboutos Division in Cameroon, as well as the attendant worm control practices. Read More

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http://dx.doi.org/10.1155/2018/8242486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280243PMC
November 2018

Biological Control of Mosquito-Borne Diseases: The Potential of -Based Interventions in an IVM Framework.

J Trop Med 2018 15;2018:1470459. Epub 2018 Nov 15.

Aix-Marseille Univ, IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Marseille, France.

People living in the tropical and subtropical regions of the world face an enormous health burden due to mosquito-borne diseases such as malaria, dengue fever, and filariasis. Historically and today, targeting mosquito vectors with, primarily, insecticide-based control strategies have been a key control strategy against major mosquito-borne diseases. However, the success to date of such approaches is under threat from multiple insecticide resistance mechanisms while vector control (VC) options are still limited. Read More

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http://dx.doi.org/10.1155/2018/1470459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276417PMC
November 2018
1 Read