16,598 results match your criteria Filariasis


Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.

Front Genet 2018 27;9:575. Epub 2018 Nov 27.

West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.

Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as and parasites such as . This ranges from investigations of disease outbreaks and pathogenesis, host and pathogen genomic variation, and host immune evasion mechanisms to identification of potential diagnostic markers and vaccine targets. High throughput genomics data generated from pathogens and animal models can be combined with host genomics and patients' health records to give advice on treatment options as well as potential drug and vaccine interactions. Read More

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November 2018

Role of IL-21 in host pathogenesis in experimental visceral leishmaniasis.

J Parasit Dis 2018 Dec 22;42(4):500-504. Epub 2018 Aug 22.

2Department of Biotechnology, Gauhati University, Guwahati, Assam India.

Visceral leishmaniasis (VL) is a major global health problem but still remains one of the neglected tropical diseases. Currently available chemotherapeutics are associated with severe toxicity and increased drug resistance. There is a need to explore for novel therapeutic strategies that could modulate host immune responses or work in synergy with chemotherapy of VL. Read More

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December 2018

(Trichocomaceae): A Natural, Eco-Friendly Mycoinsecticide for Control of Malaria, Filariasis, Dengue Vectors and Its Toxicity Assessment Against an Aquatic Model Organism .

Front Pharmacol 2018 26;9:1355. Epub 2018 Nov 26.

Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Salem, India.

Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adulticidal, and smoke toxicity effect of extract against three mosquito species, namely , and (Diptera: Culicidae). The isolated fungal strain was identified as (GenBank accession no: KX694148. Read More

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November 2018

Combining different diagnostic studies of lymphatic filariasis for risk mapping in Papua New Guinea: a predictive model from microfilaraemia and antigenaemia prevalence surveys.

Trop Med Health 2018 4;46:41. Epub 2018 Dec 4.

3College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4870 Australia.

Background: The Global Programme to Eliminate Lymphatic Filariasis has encouraged countries to follow a set of guidelines to help them assess the need for mass drug administration and evaluate its progress. Papua New Guinea (PNG) is one of the highest priority countries in the Western Pacific for lymphatic filariasis and the site of extensive research on lymphatic filariasis and surveys of its prevalence. However, different diagnostic tests have been used and thresholds for each test are unclear. Read More

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December 2018

A comparison between paper-based and m-Health tools for collating and reporting clinical cases of lymphatic filariasis and podoconiosis in Ethiopia.

Mhealth 2018 26;4:49. Epub 2018 Oct 26.

Centre for Neglected Tropical Diseases, Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.

Background: Lymphatic filariasis (LF) and podoconiosis are disabling diseases, endemic in Ethiopia. The main clinical manifestations include lymphoedema from LF and podoconiosis, and hydrocoele from LF. To ensure access to morbidity management and disability prevention (MMDP) services, data on patient numbers in each implementation unit (IU) is required. Read More

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October 2018

Larvicidal activity of some medicinal plant extracts against filariasis fever mosquito, Culex quinquefasciatus (Say.) (Diptera: Culicidae).

Comp Immunol Microbiol Infect Dis 2018 Dec 26;61:1-4. Epub 2018 Oct 26.

Department of Biological Chemistry, Centre of Biological Science and Health, Regional University of Cariri - URCA, 63105-000, Crato, CE, Brazil. Electronic address:

Objectives: The present study was aimed to find the larvicidal activity of petroleum ether, chloroform, acetone and methanolic extracts of Dichanthium foveolatum (Del.) Roberty, Leptochloa uniflora Hochst, Pancratium triflorum Roxb and Molineria trichocarpa (Wight) N.P. Read More

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December 2018
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Are Medical Laboratories Ready for the Diagnosis of Parasitic Diseases?

Authors:
Ahmet Özbilgin

EJIFCC 2018 Nov 7;29(3):171-174. Epub 2018 Nov 7.

Department of Parasitology, Faculty of Medicine, University of Manisa Celal Bayar, Manisa, Turkey.

Economic instability, destabilisation with armed conflagration, religious and ethnic conflicts are the most important driving factors for migrations towards Europe. Mediterranean countries are important route for refugees who emigrate from the Middle East, Africa and Asia. Viral, bacterial, parasitic and fungal diseases carried by these refugees constitute a significant health risk in Mediterranean countries. Read More

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November 2018
4 Reads

Exploring the homolog of a novel proinflammatory microfilarial sheath protein (MfP) of Wuchereria bancrofti in the adult-stage bovine filarial parasite Setaria cervi.

J Helminthol 2018 Nov 27:1-6. Epub 2018 Nov 27.

Parasitology Laboratory,Department of Zoology (Centre for Advanced Studies),Visva-Bharati University,Santiniketan-731 235,India.

A novel microfilarial sheath protein (MfP) of the human filarial parasite Wuchereria bancrofti and its proinflammatory activity on host macrophages were identified recently. MfP is a homolog of the nematode bestrophin-9 superfamily that acts as a ligand of macrophage Toll-like receptor 4 (TLR4) to induce inflammation through NF-κB activation. Therefore, the presence and functional implication of this novel protein in adult-stage parasites were open questions to answer. Read More

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November 2018
1 Read

Perceived threat and benefit toward community compliance of filariasis' mass drug administration in Pekalongan district, Indonesia.

Risk Manag Healthc Policy 2018 23;11:189-197. Epub 2018 Oct 23.

Department of Epidemiology and Tropical Diseases, Faculty of Public Health, Diponegoro University, Semarang, Indonesia,

Purpose: Lymphatic filariasis (LF) is a chronic infection of , and and is a mosquito-transmitted disease. Mass drug administration (MDA) needs to be done annually to control LF and requires adherence of endemic populations to take medication properly. Maintaining high coverage of MDA is a challenge because the activity needs to be done in several years. Read More

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October 2018
1 Read

Backpack PCR: A point-of-collection diagnostic platform for the rapid detection of Brugia parasites in mosquitoes.

PLoS Negl Trop Dis 2018 Nov 21;12(11):e0006962. Epub 2018 Nov 21.

Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America.

Background: Currently, molecular xenomonitoring efforts for lymphatic filariasis rely on PCR or real-time PCR-based detection of Brugia malayi, Brugia timori and Wuchereria bancrofti in mosquito vectors. Most commonly, extraction of DNA from mosquitoes is performed using silica column-based technologies. However, such extractions are both time consuming and costly, and the diagnostic testing which follows typically requires expensive thermal cyclers or real-time PCR instruments. Read More

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November 2018
2 Reads

Decreased nematode clearance & anti-phosphorylcholine specific IgM responses in mannose-binding lectin deficient mice.

Immunol Cell Biol 2018 Nov 20. Epub 2018 Nov 20.

The Royal Veterinary College, Department of Comparative Biomedical Sciences, Royal College Street, London, NW1 0TU, United Kingdom.

Brugia malayi is a nematode that causes human lymphatic filariasis. Previously, we showed that mannose binding lectin (MBL) -A is necessary for clearance of B. malayi microfilariae in mice and presence of MBL-A is linked with maximal levels of parasite-specific IgM. Read More

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November 2018

Hydrocele Due to Wuchereria bancrofti Infection.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

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November 2018

Identification and characterization of Loa loa antigens responsible for cross-reactivity with rapid diagnostic tests for lymphatic filariasis.

PLoS Negl Trop Dis 2018 Nov 16;12(11):e0006963. Epub 2018 Nov 16.

Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

The Global Program to Eliminate Lymphatic Filariasis (LF) relies on rapid diagnostic tests (RDTs) to determine where annual mass drug administration for LF is required and when it can be stopped. These tests detect a Wuchereria bancrofti glycoprotein in the blood of infected persons via a carbohydrate moiety recognized by the monoclonal antibodies AD12 and DH6.5. Read More

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November 2018
3 Reads

Integrated Management of Skin NTDs-Lessons Learned from Existing Practice and Field Research.

Authors:
Rie R Yotsu

Trop Med Infect Dis 2018 Nov 14;3(4). Epub 2018 Nov 14.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8102, Japan.

Integration of neglected tropical diseases (NTDs) into the public health agenda has been a priority in global health for the last decade. Because a number of these diseases share not only the geographical distribution, but also a common feature which is skin involvement, bringing together a sub-group of 'skin NTDs' is one way forward to promote further integration among NTDs. With these diseases, which include leprosy, Buruli ulcer, yaws, mycetoma, lymphatic filariasis, and leishmaniasis, patients may be left with life-long deformities and disabilities when diagnosis and treatment are delayed. Read More

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November 2018
1 Read

Bioassay and molecular study for detection of insecticide resistance dengue causing mosquito vectors.

Indian J Med Microbiol 2018 Jul-Sep;36(3):435-438

Division of Entomology and Filariasis, Regional Medical Research Centre (ICMR), Dibrugarh, Assam, India.

Nowadays, dengue infection creates a major problem across the country. The vector species carrying dengue infection has progressively started to developed resistance against most of the currently used insecticides. Hence, a study was carried out in dengue-endemic areas of Assam and Arunachal Pradesh to find the current situation of insecticide susceptibility status of dengue vectors. Read More

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November 2018
11 Reads
1.040 Impact Factor

Novel Findings of Anti-Filarial Drug Target and Structure-Based Virtual Screening for Drug Discovery.

Int J Mol Sci 2018 Nov 13;19(11). Epub 2018 Nov 13.

Department of Infection Biology, Wonkwang University School of Medicine, Iksan 54538, Korea.

Lymphatic filariasis and onchocerciasis caused by filarial nematodes are important diseases leading to considerable morbidity throughout tropical countries. Diethylcarbamazine (DEC), albendazole (ALB), and ivermectin (IVM) used in massive drug administration are not highly effective in killing the long-lived adult worms, and there is demand for the development of novel macrofilaricidal drugs affecting new molecular targets. A Ca binding protein, calumenin, was identified as a novel and nematode-specific drug target for filariasis, due to its involvement in fertility and cuticle development in nematodes. Read More

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November 2018
1 Read

Lymphatic filariasis transmission in Rufiji District, southeastern Tanzania: infection status of the human population and mosquito vectors after twelve rounds of mass drug administration.

Parasit Vectors 2018 Nov 13;11(1):588. Epub 2018 Nov 13.

WHO Regional Office for Africa, Brazzaville, Republic of the Congo.

Background: Control of lymphatic filariasis (LF) in most of the sub-Saharan African countries is based on annual mass drug administration (MDA) using a combination of ivermectin and albendazole. Monitoring the impact of this intervention is crucial for measuring the success of the LF elimination programmes. This study assessed the status of LF infection in Rufiji district, southeastern Tanzania after twelve rounds of MDA. Read More

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November 2018
5 Reads

Prevention and Control Strategies for Parasitic Infections in the Korea Centers for Disease Control and Prevention.

Korean J Parasitol 2018 Oct 31;56(5):401-408. Epub 2018 Oct 31.

Department of Parasitology and Tropical Medicine, Inha University School of Medicine, Incheon 22212, Korea.

Korea is successfully controlled intestinal parasitic infections owing to economic development and high health consciousness. The Division of Vectors and Parasitic Diseases (formerly the Division of Malaria and Parasitology) is in the Center for Laboratory Control of Infectious Diseases of the Korea Centers for Disease Control and Prevention. It has been the governmental agency responsible for controlling and leading scientific research on parasitic diseases. Read More

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October 2018
4 Reads

The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar.

PLoS Negl Trop Dis 2018 Nov 12;12(11):e0006944. Epub 2018 Nov 12.

College of Medicine & Dentistry, Division of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.

Lymphatic filariasis is widely endemic in Myanmar. Despite the establishment of an elimination program in 2000, knowledge of the remaining burden of disease relies predominantly on programmatic information. To assist the program, we conducted an independent cross-sectional household cluster survey to determine the prevalence of filariasis infection, morbidity and mass-drug administration coverage in four townships of the Mandalay Region: Amarapura, Patheingyi, Tada-U and Wundwin. Read More

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November 2018
5 Reads

Estimating the elimination feasibility in the 'end game' of control efforts for parasites subjected to regular mass drug administration: Methods and their application to schistosomiasis.

PLoS Negl Trop Dis 2018 Nov 12;12(11):e0006794. Epub 2018 Nov 12.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

Progress towards controlling and eliminating parasitic worms, including schistosomiasis, onchocerciasis, and lymphatic filariasis, is advancing rapidly as national governments, multinational NGOs, and pharmaceutical companies launch collaborative chemotherapeutic control campaigns. Critical questions remain regarding the potential for achieving elimination of these infections, and analytical methods can help to quickly estimate progress towards-and the probability of achieving-elimination over specific timeframes. Here, we propose the effective reproduction number, Reff, as a proxy of elimination potential for sexually reproducing worms that are subject to poor mating success at very low abundance (positive density dependence, or Allee effects). Read More

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November 2018
5 Reads

Changes in canine serum N-glycosylation as a result of infection with the heartworm parasite Dirofilaria immitis.

Sci Rep 2018 Nov 9;8(1):16625. Epub 2018 Nov 9.

New England Biolabs Inc., Ipswich, Massachusetts, 01938, USA.

Filariases are diseases caused by infection with filarial nematodes and transmitted by insect vectors. The filarial roundworm Dirofilaria immitis causes heartworm disease in dogs and other carnivores. D. Read More

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November 2018
4 Reads

Advancing toward the Elimination of Lymphatic Filariasis.

Authors:
David H Molyneux

N Engl J Med 2018 11;379(19):1871-1872

From the Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

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November 2018
1 Read

A Trial of a Triple-Drug Treatment for Lymphatic Filariasis.

N Engl J Med 2018 11;379(19):1801-1810

From the Center for Global Health and Diseases, Case Western Reserve University School of Medicine (C.L.K., Y.-C.C., B.M., J.W.K.), and the Veterans Affairs Medical Center (C.L.K.), Cleveland; Papua New Guinea Institute of Medical Research, Goroka (J.S., N.S., S.S., L.J.R., P.M.S.); and the Division of Biostatistics (C.W.G.) and Department of Medicine, Infectious Diseases Division (G.J.W.), Washington University School of Medicine, St. Louis.

Background: The World Health Organization has targeted lymphatic filariasis for global elimination by 2020 with a strategy of mass drug administration. This trial tested whether a single dose of a three-drug regimen of ivermectin plus diethylcarbamazine plus albendazole results in a greater sustained clearance of microfilariae than a single dose of a two-drug regimen of diethylcarbamazine plus albendazole and is noninferior to the two-drug regimen administered once a year for 3 years.

Methods: In a randomized, controlled trial involving adults from Papua New Guinea with Wuchereria bancrofti microfilaremia, we assigned 182 participants to receive a single dose of the three-drug regimen (60 participants), a single dose of the two-drug regimen (61 participants), or the two-drug regimen once a year for 3 years (61 participants). Read More

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November 2018
7 Reads

Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti.

Cell Mol Biol (Noisy-le-grand) 2018 Oct 30;64(13):69-73. Epub 2018 Oct 30.

Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Khalid University. Abha, KSA.

Glutathione-S-transferase also referred as GST is one of the major detoxification enzymes in parasitic helminths. The crucial role played by GST in various chronic infections has been well reported. The dependence of nematodes on detoxification enzymes to maintain their survival within the host established the crucial role of GST in filariasis and other related diseases. Read More

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October 2018
2 Reads

Mansonellosis, the most neglected human filariasis.

New Microbes New Infect 2018 Nov 1;26:S19-S22. Epub 2018 Sep 1.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

Human mansonellosis is caused by and the three main filarial species in the genus Despite accumulating evidence of a high prevalence in endemic areas, there is currently no filariasis control programme targeting mansonellosis. The health-related impact on people living with these filariae remains unknown, and evidences regarding treatment strategies are scarce. Like other neglected diseases, it mainly affects poor populations living in tropical and subtropical climates. Read More

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November 2018
4 Reads

Filariasis elimination, vector control and eradication challenges: Commentary on Webber, R. Eradication of Wuchereria bancrofti infection through vector control. Trans Roy Soc Trop Med and Hyg 1979;73:722-4.

Authors:
David H Molyneux

Trans R Soc Trop Med Hyg 2018 Nov;112(11):476-478

Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

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November 2018

Effect of Serratia AS1 (Enterobacteriaceae: Enterobacteriales) on the Fitness of Culex pipiens (Diptera: Culicidae) for Paratransgenic and RNAi Approaches.

J Med Entomol 2018 Nov 2. Epub 2018 Nov 2.

Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The mosquito Culex pipiens is the primary vector of Rift Valley fever, West Nile, encephalitis, and Zika viruses, and periodic lymphatic filariasis. Developing insecticide resistance in mosquitoes demands the development of new approaches to fight these diseases. Paratransgenesis and RNAi approaches by using engineered bacteria have been shown to reduce mosquito vector competence. Read More

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November 2018
3 Reads

A preliminary survey of filarial parasites in dogs and cats in Sri Lanka.

PLoS One 2018 2;13(11):e0206633. Epub 2018 Nov 2.

Department of Parasitology, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.

Human brugian filariasis has re-emerged in Sri Lanka after a quiescent period of four decades. This study investigated the prevalence of canine and feline filarial parasites in three localities with human sub-periodic brugian filariasis, in order to determine their potential reservoir status. All reachable dogs and cats, both stray and domestic, within a 350m radius of an index case of brugian filariasis in three locations (Madampe, Wattala and Weliweriya) were screened for microfilariae using Giemsa stained thick blood smears. Read More

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November 2018
3 Reads
3.230 Impact Factor

"Wherever doctors cannot reach, the sunshine can": overcoming potential barriers to malaria elimination interventions in Haiti.

Malar J 2018 Oct 29;17(1):393. Epub 2018 Oct 29.

Center for Applied Malaria Research and Evaluation, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA.

Background: Haiti and the Dominican Republic, the only two Caribbean countries with endemic malaria transmission, are committed to eliminating malaria. With a Plasmodium falciparum prevalence under 1% and a highly focal transmission, the efforts towards elimination in Haiti will include several community-based interventions that must be tailored to the local sociocultural context to increase their uptake. However, little is known about local community perceptions regarding malaria and the planned elimination interventions. Read More

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October 2018
4 Reads

Knowledge, attitude and practices of snakebite management amongst health workers in Cameroon: Need for continuous training and capacity building.

PLoS Negl Trop Dis 2018 Oct 25;12(10):e0006716. Epub 2018 Oct 25.

Cameroon Society of Epidemiology, Yaounde, Cameroon.

Background: Snakebite has only recently been recognized as a neglected tropical disease by the WHO. Knowledge regarding snakebites and its care is poor both at the population level, and at the health care staff level. The goal of this study was to describe the level of knowledge and clinical practice regarding snakebite among health care staff from Cameroon. Read More

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October 2018
6 Reads

Update on the current status of onchocerciasis in Côte d'Ivoire following 40 years of intervention: Progress and challenges.

PLoS Negl Trop Dis 2018 Oct 23;12(10):e0006897. Epub 2018 Oct 23.

Washington University School of Medicine, Department of Medicine, Infectious Diseases Division, St. Louis, Missouri, United States of America.

Background: Onchocerciasis control in Côte d'Ivoire started with aerial insecticide spraying in 1974 and continued with community directed treatment with ivermectin (CDTi) from 1992 to the present. Onchocerciasis and lymphatic filariasis (LF) are co-endemic in 46 of the 81 health districts in the country. Fourteen and 12 districts are endemic for only LF or onchocerciasis, respectively. Read More

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October 2018
1 Read

Laboratory Evaluation of a Rapid IgG4 Antibody Test (BLF Rapid™) for Bancroftian Filariasis.

Am J Trop Med Hyg 2018 Dec;99(6):1587-1590

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

At the end phase of the Global Programme to Eliminate Lymphatic Filariasis, antibody testing may have a role in decision-making for bancroftian filariasis-endemic areas. This study evaluated the diagnostic performance of BLF Rapid, a prototype immunochromatographic IgG4-based test using SXP recombinant protein, for detection of bancroftian filariasis. The test was evaluated using 258 serum samples, comprising 96 samples tested at Universiti Sains Malaysia (in-house) and 162 samples tested independently at three international laboratories in the USA and India, and two laboratories in Malaysia. Read More

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December 2018
6 Reads

Eradicating Filariasis.

J Assoc Physicians India 2018 Apr;66(4):88-90

Professor of Medicine (Retd.), TN Medical College, Hon. Physician, Bhatia Hospital, Mumbai, Maharashtra.

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Clinical characteristics of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan.

Seizure 2018 Nov 5;62:108-115. Epub 2018 Oct 5.

Neglected Tropical Diseases Unit, Ministry of Health, Juba, Sudan. Electronic address:

Purpose: To describe the clinical manifestations of persons with epilepsy (PWE) in onchocerciasis endemic villages in South Sudan.

Methods: During a survey in Maridi County in May 2018, PWE were interviewed and examined in their households by a clinical officer or medical doctor. Onchocerciasis-associated epilepsy (OAE) was defined as ≥2 seizures without any obvious cause, starting between the ages of 3-18 years in previously healthy persons who had resided for at least 3 years in the onchocerciasis endemic area. Read More

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November 2018
2 Reads

Avian Filariasis in Backyard Chickens in Japan.

Avian Dis 2018 Sep;62(3):326-329

D National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan.

In May 2017, a hen in a backyard chicken flock in Japan exhibited mild clinical signs, and the bird was examined for diagnosis. Unexpectedly, many microfilariae were observed in the lung by histologic examination, although no adult worms were detected within the body. In a blood test performed in July, microfilaremia was confirmed in a few clinically normal chickens of the same flock. Read More

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September 2018
6 Reads

Substantiating freedom from parasitic infection by combining transmission model predictions with disease surveys.

Nat Commun 2018 10 18;9(1):4324. Epub 2018 Oct 18.

Emory University and The Carter Center, One Copenhill, 453 Freedom Parkway, Atlanta, GA, 30307, USA.

Stopping interventions is a critical decision for parasite elimination programmes. Quantifying the probability that elimination has occurred due to interventions can be facilitated by combining infection status information from parasitological surveys with extinction thresholds predicted by parasite transmission models. Here we demonstrate how the integrated use of these two pieces of information derived from infection monitoring data can be used to develop an analytic framework for guiding the making of defensible decisions to stop interventions. Read More

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October 2018
2 Reads

Development of an urban molecular xenomonitoring system for lymphatic filariasis in the Recife Metropolitan Region, Brazil.

PLoS Negl Trop Dis 2018 Oct 16;12(10):e0006816. Epub 2018 Oct 16.

Department of Parasitology, Institute Aggeu Magalhães(IAM/FIOCRUZ Pernambuco), Recife, Brazil.

Introduction: Molecular xenomonitoring (MX)-pathogen detection in the mosquito rather than human-is a promising tool for lymphatic filariasis (LF) surveillance. In the Recife Metropolitan Region (RMR), the last LF focus in Brazil, Culex quinquefasciatus mosquitoes have been implicated in transmitting Wuchereria bancrofti parasites. This paper presents findings on the ideal mosquito collection method, mosquito dispersion, W. Read More

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October 2018
5 Reads

Immunodiagnostic potential of Wuchereria bancrofti L1 antigen-based filarial immunoglobulin G4 detection assay.

Trans R Soc Trop Med Hyg 2018 Oct 15. Epub 2018 Oct 15.

Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India.

Background: After mass drug administration to eliminate human lymphatic filariasis, there is a need for surveillance to detect the measurable endpoint of the program.

Methods: An immunodominant seroreactive clone, WbL1, was identified through immunoscreening of a Wuchereria bancrofti L3 complementary DNA expression library. Recombinant WbL1 (rWbL1) was analysed with sera from W. Read More

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October 2018
1 Read
1.930 Impact Factor

A surveillance system for lymphatic filariasis after its elimination in Sri Lanka.

Parasitol Int 2019 Feb 9;68(1):73-78. Epub 2018 Oct 9.

Department of Bacteriology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan. Electronic address:

Lymphatic filariasis (LF) has been declared eliminated in Sri Lanka in September 2016. To maintain elimination status, a surveillance system to detect hidden endemic foci or LF resurgence is of highest priority. In this paper, we have reported an investigation of LF transmission in Trincomalee district where a surveillance program was not carried out due to 30 years of civil unrest. Read More

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February 2019
2 Reads
2.110 Impact Factor

Epididymal filariasis a rare presentation of testicular pain.

Urol Case Rep 2019 Jan 29;22:3-5. Epub 2018 Sep 29.

Department of Surgery at the Sunshine Coast University Hospital, 6 Doherty Street, Birtinya, Queensland, 4575, Australia.

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January 2019

Cloning, large-scale production and characterization of fusion protein (P-TUFT-ALT-2) of Brugian abundant larval transcript-2 with tuftsin in Pichia pastoris.

Prep Biochem Biotechnol 2018 Oct 10:1-11. Epub 2018 Oct 10.

a Centre for Biotechnology , Anna University , Chennai , India.

Lymphatic filariasis is a "disease of poor people" due to a large section of affected people with economic backwardness. Therefore, successful elimination of this disease requires a cost-effective prophylactic agent such as vaccine along with conventional drugs. The Abundant Larval Transcript-2 (BmALT-2) protein of Brugia malayi has been recognized as the most potential vaccine candidate. Read More

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October 2018

Wucherria bancrofti glutathione S-Transferase: Insights into the 2.3 Å resolution X-ray structure and function, a therapeutic target for human lymphatic filariasis.

Biochem Biophys Res Commun 2018 Nov 6;505(4):979-984. Epub 2018 Oct 6.

Centre for Biotechnology, Anna University, India. Electronic address:

The notoriety of parasitic nematode survival is directly related to chronic pathogenicity, which is evident in human lymphatic filariasis. It is a disease of poverty which causes severe disability affecting more than 120 million people worldwide. These nematodes down-regulate host immune system through a myriad of strategies that includes secretion of antioxidant and detoxification enzymes like glutathione-S-transferases (GSTs). Read More

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November 2018

Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.

PLoS Negl Trop Dis 2018 Oct 8;12(10):e0006772. Epub 2018 Oct 8.

Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, United States of America.

Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from Brugia malayi (Bm-FAR-1 and Bm-FAR-2) were expressed as recombinant proteins, and their ligand binding, structural characteristics, and immunogenicities examined. Circular dichroism showed that rBm-FAR-1 and rBm-FAR-2 are similarly rich in α-helix structure. Read More

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October 2018
1 Read

Quantifying the value of surveillance data for improving model predictions of lymphatic filariasis elimination.

PLoS Negl Trop Dis 2018 Oct 8;12(10):e0006674. Epub 2018 Oct 8.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Background: Mathematical models are increasingly being used to evaluate strategies aiming to achieve the control or elimination of parasitic diseases. Recently, owing to growing realization that process-oriented models are useful for ecological forecasts only if the biological processes are well defined, attention has focused on data assimilation as a means to improve the predictive performance of these models.

Methodology And Principal Findings: We report on the development of an analytical framework to quantify the relative values of various longitudinal infection surveillance data collected in field sites undergoing mass drug administrations (MDAs) for calibrating three lymphatic filariasis (LF) models (EPIFIL, LYMFASIM, and TRANSFIL), and for improving their predictions of the required durations of drug interventions to achieve parasite elimination in endemic populations. Read More

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October 2018

Morbidity Pattern and Role of Community Health Workers in Urban Slums of Durg and Bhilai City of Chhattisgarh.

Indian J Community Med 2018 Jul-Sep;43(3):229-232

Indian Institute of Public Health, Gandhinagar, Gujarat, India.

Introduction: In 2002, the Government of Chhattisgarh initiated a Community Health Worker program called the Mitanin Program, to strengthen the health system of Chhattisgarh. The current study was conducted with the twin objectives to assess morbidity pattern and health-seeking behavior in urban slums of Durg and Bhilai to understand the role of Mitanins in health seeking of their slum population.

Methods: Ten urban slums, five each from Durg and Bhilai were selected through simple random sampling for the study. Read More

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October 2018
6 Reads

Seroprevalence of sarcocystosis in the local communities of Pangkor and Tioman Islands using recombinant surface antigens 3 (rSAG3) of Sarcocystis falcatula.

Trop Med Int Health 2018 Dec 23;23(12):1374-1383. Epub 2018 Oct 23.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Objective: To investigate the seroprevalence of Sarcocystosis in the local communities of Pangkor and Tioman islands, Malaysia, by using antigenic recombinant surface antigens 2 and 3 from Sarcocystis falcatula (rSfSAG2 and rSfSAG3) as the target proteins via Western blot and ELISA assays.

Methods: SfSAG2 and SfSAG3 genes were isolated from S. falcatula and expressed in Escherichia coli expression system. Read More

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December 2018
10 Reads
2.330 Impact Factor

How lymphatic filariasis was eliminated from an urban poor setting in Santo Domingo, Dominican Republic.

Int Health 2018 Oct 4. Epub 2018 Oct 4.

The Taskforce for Global Health, 330 West Ponce de Leon Ave, Decatur, Georgia, USA.

Background: While progress has been made in the elimination of lymphatic filariasis, challenges that call for innovative approaches remain. Program challenges are increasingly observed in 'hard-to-reach' populations: urban dwellers, migrant populations, those living in insecurity, children who are out of school and areas where infrastructure is weak and education levels are low. 'Business-as-usual' approaches are unlikely to work. Read More

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October 2018
1 Read

Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment.

Int J Parasitol Drugs Drug Resist 2018 Dec 22;8(3):587-595. Epub 2018 Sep 22.

Department of Infectious Diseases, University of Georgia, Athens, GA, 30602, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA. Electronic address:

Mass administration of macrocyclic lactones targets the transmission of the causative agents of lymphatic filariasis to their insect vectors by rapidly clearing microfilariae (Mf) from the circulation. It has been proposed that the anti-filarial action of these drugs may be mediated through the host immune system. We recently developed an in vitro assay for monitoring the attachment to and killing of B. Read More

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December 2018
13 Reads

Low Microfilaremia Levels in Three Districts in Coastal Ghana with at Least 16 Years of Mass Drug Administration and Persistent Transmission of Lymphatic Filariasis.

Trop Med Infect Dis 2018 Sep 26;3(4). Epub 2018 Sep 26.

Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.

Ghana has been implementing mass drug administration (MDA) of ivermectin and albendazole for the elimination of lymphatic filariasis (LF) since the year 2000, as part of the Global Programme to Eliminate Lymphatic Filariasis (GPELF). It was estimated that 5⁻6 years of treatment would be sufficient to eliminate the disease. Tremendous progress has been made over the years, and treatment has stopped in many disease endemic districts. Read More

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September 2018
8 Reads