1,184 results match your criteria Filaria Journal [Journal]


Eprinomectin pour-on: Prevention of gastrointestinal and pulmonary nematode infections in sheep.

Vet Parasitol 2018 Dec 8;264:42-46. Epub 2018 Nov 8.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101 Rohrdorf, Germany.

The present study was conducted to further characterize the anthelmintic activity of the 0.5% w/v topical formulation of eprinomectin (EPRINEX Pour-on, Merial) when administered at 1 mg/kg body weight to sheep in preventing the establishment of induced gastrointestinal and pulmonary nematode infections. Thirty-six female Merino sheep (∼4 months of age, weighing 27. Read More

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December 2018

High genetic diversity in the Dirofilaria repens species complex revealed by mitochondrial genomes of feline microfilaria samples from Narathiwat, Thailand.

Transbound Emerg Dis 2018 Oct 3. Epub 2018 Oct 3.

Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Dirofilaria repens is a zoonotic, mosquito-borne filaria infecting carnivores, particularly dogs. It is expanding its range in Europe but epidemiological information is sparse for other Eurasian regions. In Hong Kong and India, the closely related species Candidatus Dirofilaria hongkongensis was proposed. Read More

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October 2018

Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study.

PLoS Negl Trop Dis 2018 Sep 25;12(9):e0006824. Epub 2018 Sep 25.

ICMR-Regional Medical Research Center, Chandrasekharpur, Bhubaneswar, Odisha, India.

Background: Current Global Program to Eliminate Lymphatic Filariasis (GPELF) that prohibits pregnant mothers and children below two years of age from coverage targeted interruption of transmission after 5-6 rounds of annual mass drug administration (MDA). However, after more than 10 rounds of MDA in India the target has not been achieved, which poses challenge to the researchers and policy makers. Several studies have shown that in utero exposure to maternal filarial infections plays certain role in determining the susceptibility and disease outcome in children. Read More

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September 2018
10 Reads

Breast filariasis.

IDCases 2018 7;14:e00453. Epub 2018 Sep 7.

Department of Pathology, AIIMS, New Delhi- 110029, India.

Filariasis is a global health problem and is a major social and economical burden in tropical countries in Asia, Africa and few of the South American countries [1,2]. In india, filariasis endemic in number of states including Bihar, Kerala, Uttar Pradesh, Andhra Pradesh and Tamil Nadu is found chiefly along the banks of rivers and sea coastal areas. We present a case of 28 year female patient who presented with lump in her left breast for three months and was not associated with pain or discharge from nipple. Read More

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September 2018

IL-6 is required for protective immune responses against early filarial infection.

Int J Parasitol 2018 Oct 1;48(12):925-935. Epub 2018 Sep 1.

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany. Electronic address:

IL-6 has a wide range of biological activities that includes anti- and pro-inflammatory aspects. In this study, we investigated the role of IL-6 in immune responses to the rodent filarial nematode Litomosoides sigmodontis, a model for human filarial infections. IL-6 mice had a significantly increased worm burden after natural infection compared with wild type controls at early time points p. Read More

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October 2018
10 Reads

Parasite prevalence in Mycobacterium spp. infected dairy goats in the region of Murcia (south-east Spain).

Rev Sci Tech 2017 Dec;36(3):905-916

Eighty-four Murciano-Granadina dairy goats slaughtered in the region of Murcia (South-East Spain) were necropsied to evaluate parasitic infections. The majority of the animals (94.0%) were parasitised and multiple infections were present. Read More

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December 2017
1 Read

Mosquitoes (Diptera: Culicidae) and mosquito-borne diseases in Mali, West Africa.

Parasit Vectors 2018 Aug 13;11(1):467. Epub 2018 Aug 13.

MIVEGEC Unit, IRD-CNRS-Univ. Montpellier, Montpellier, France.

Mosquito-borne diseases cause major human diseases in almost every part of the world. In West Africa, and notably in Mali, vector control measures help reduce the impact of mosquito-borne diseases, although malaria remains a threat to both morbidity and mortality. The most recent overview article on mosquitoes in Mali was published in 1961, with a total of 88 species. Read More

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August 2018
2 Reads

Current discovery progress of some emerging anti-infective chalcones: Highlights from 2016 to 2017.

Curr Drug Discov Technol 2018 Jul 20. Epub 2018 Jul 20.

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar 470003, Madhya Pradesh. India.

The anti-infective potentials of the natural products are very well known for centuries and are a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones, flavonols, flavanones, flavanols, proanthocyanidins, anthocyanidins, chalcones, and aurones. The chalcone or 1,3-diphenyl-2E-propene-1-one represents the class of natural product which comprise of benzylideneacetophenone function; i. Read More

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July 2018
1 Read

Filarial tropical pulmonary eosinophilia: a condition masquerading asthma, a series of 12 cases.

J Asthma 2018 Aug 24:1-8. Epub 2018 Aug 24.

a Department of Pediatrics , PGIMER, Dr.RML Hospital , New Delhi , India.

Introduction: Tropical pulmonary eosinophilia (TPE) is a form of occult filariasis, clinically characterized by paroxysmal cough, wheezing and dyspnea which is often misdiagnosed and treated as asthma. These manifestations result from a host immune response to trapped antigens of the microfilarial parasites Wuchereria bancrofti or Brugia malayi in the pulmonary microcirculation.

Case Study: We describe three rare presentations of TPE (cor pumonale, cystic lung disease and respiratory distress mimicking acute severe asthma) in our series of 12 cases. Read More

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August 2018
4 Reads

Leishmania donovani molecules recognized by sera of filaria infected host facilitate filarial infection.

Parasitol Res 2018 Sep 26;117(9):2901-2912. Epub 2018 Jun 26.

Division of Parasitology, CSIR-Central Drug Research Institute, New Campus, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.

We earlier found that F6 fraction of human filaria Brugia malayi cross-reacted with sera of Leishmania donovani infected hamsters and immunization with F6 inhibited both filarial and leishmanial infections. In the present study, we identified a 52.9-93. Read More

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September 2018
1 Read

Coinfection of malaria and filaria with unusual crisis forms.

Trop Parasitol 2018 Jan-Jun;8(1):44-46. Epub 2018 May 28.

Department of Pathology, TN Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.

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Occurrence of Dipetalonema gracile in a wild population of woolly monkey Lagothrix poeppiigii in the northeastern Peruvian Amazon.

Rev Bras Parasitol Vet 2018 Apr-Jun;27(2):154-160. Epub 2018 May 24.

Laboratório de Biologia Celular e Helmintologia "Profa. Dra. Reinalda Marisa Lanfredi", Instituto de Ciências Biológicas, Universidade Federal do Pará - UFPA, Belém, PA, Brasil.

Dipetalonema gracile (Rudolphi, 1809) (Filarioidea: Onchocercidae) is one of six species of cavities filarial parasites of Neotropical non-human primates. The present study recorded the occurrence of D. gracile, provides morphological and morphometric data and extends the geographical distribution. Read More

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Case Report: Filaria or Megasperm? A Cause of an Ultrasonographic "Filarial Dance Sign".

Am J Trop Med Hyg 2018 Jul 10;99(1):102-103. Epub 2018 May 10.

Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Canada.

Bancroftian filariasis can cause genital abnormalities related to chronic inflammation and obstruction of the afferent lymphatic vessels, and may demonstrate a "filarial dance sign" on scrotal ultrasound with mobile echogenic particles observed. We present a patient with a positive "filarial dance sign," travel within Latin America, and negative filarial serology. Read More

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July 2018
1 Read

Filaria specific antibody response profiling in plasma from anti-retroviral naïve Loa loa microfilaraemic HIV-1 infected people.

BMC Infect Dis 2018 04 4;18(1):160. Epub 2018 Apr 4.

Laboratory of vaccinology/biobanking, CIRCB, Messa, Yaounde, Cameroon.

Background: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis. Read More

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April 2018
17 Reads
2.610 Impact Factor

Living together: Malaria and filaria.

Am J Hematol 2018 Oct 30;93(10):1294-1295. Epub 2018 Mar 30.

Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

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October 2018
5 Reads

Association between urticaria and nematode infections.

Allergy Asthma Proc 2018 Mar;39(2):86-95

From the School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino," Messina, Italy.

Background: The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Read More

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March 2018
5 Reads

Cord Blood Antiparasite Interleukin 10 as a Risk Marker for Compromised Vaccine Immunogenicity in Early Childhood.

J Infect Dis 2018 Apr;217(9):1426-1434

Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio.

Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' antiparasite cytokine profiles relate to immunoglobulin G (IgG) responses to standard vaccination during infancy.

Methods: A total of 450 Kenyan women were tested for parasitic infections during pregnancy. Read More

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April 2018
12 Reads

Filaria surveys in the Armed Forces: Need for a revisit.

Med J Armed Forces India 2017 Oct 17;73(4):332-337. Epub 2016 Nov 17.

Associate Professor, Dept of Community Medicine, Armed Forces Medical College, Pune 411040, India.

Background: Routine annual filarial surveys are conducted amongst various categories of military personnel and their families as per policies in vogue in the Armed Forces. The neglect and inattention faced by this disease needs to be addressed in terms of policy, provisioning and processes while dealing with filariasis in the Armed Forces.

Methods: Routine annual filarial survey was conducted in a garrison during the months of Nov and Dec in 2013 and 2014. Read More

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October 2017
1 Read

Answer to December 2017 Photo Quiz.

J Clin Microbiol 2017 12;55(12):3568

Yale School of Medicine, Section of Infectious Diseases, AIDS Program, New Haven, Connecticut, USA

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December 2017
3 Reads

Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.

PLoS One 2017 15;12(11):e0188138. Epub 2017 Nov 15.

Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.

Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive. Read More

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December 2017
6 Reads

Phylogenetic study based on 28S rRNA gene sequencing of isolated from the filaria endemic areas of Bankura district, West Bengal, India.

J Parasit Dis 2017 Dec 11;41(4):981-986. Epub 2017 May 11.

Department of Nutrition, A.K.P.C Mahavidyalaya, Bengai, Hooghly, India.

Lymphatic filariasis is one of the major public health concern in India, and Bankura district of West Bengal is one of the main filaria prone area of the country. is the causative organism and is the main vector of lymphatic filariasis in India. In the present study, infection and infectivity rate of filarial vector were determined. Read More

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December 2017
5 Reads

Detection of Cercopithifilaria bainae in western Romania.

Parasitol Res 2017 Nov 27;116(11):3235-3238. Epub 2017 Sep 27.

Institute for Diagnosis and Animal Health, Bucharest, Romania.

Cercopithifilaria species are tick-transmitted filarial parasites of mammals. In Europe, three Cercopithifilaria spp. are known to parasitize dogs, all occurring mainly in the Mediterranean countries. Read More

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November 2017
8 Reads

Persistent 'hotspots' of lymphatic filariasis microfilaraemia despite 14 years of mass drug administration in Ghana.

Trans R Soc Trop Med Hyg 2016 12;110(12):690-695

Family Health International (FHI360), P.O. Box 4033, Accra, Ghana.

Background: Among the 216 districts in Ghana, 98 were declared endemic for lymphatic filariasis in 1999 after mapping. Pursuing the goal of elimination, WHO recommends annual treatment using mass drugs administration (MDA) for at least 5 years. MDA was started in the country in 2001 and reached national coverage in 2006. Read More

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December 2016
26 Reads

IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity.

Int J Parasitol 2017 12 30;47(14):951-960. Epub 2017 Aug 30.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Germany; German Centre for Infection Research (DZIF), Partner Site, Bonn-Cologne, Bonn, Germany. Electronic address:

Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. Read More

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December 2017
11 Reads

Incidental detection of two adult gravid filarial worms in breast: a case report.

BMC Res Notes 2017 Aug 16;10(1):412. Epub 2017 Aug 16.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai, Maharashtra, 4900012, India.

Background: Microfilaria is a major public health problem in tropical and subtropical countries and is an endemic problem in India. Wuchereria bancrofti is the commonest filarial infection. In some lesions, microfilariae and adult filarial worm have been incidentally detected in fine-needle aspirates. Read More

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August 2017
7 Reads

Enhanced Adhesion of Mosquitoes to Rough Surfaces.

ACS Appl Mater Interfaces 2017 Jul 6;9(28):24373-24380. Epub 2017 Jul 6.

Department of Chemical and Biomolecular Engineering, Tulane University , New Orleans, Louisiana 70118, United States.

Insects and small animals capable of adhering reversibly to a variety of surfaces employ the unique design of the distal part of their legs. In the case of mosquitoes, their feet are composed of thousands of micro- and nanoscale protruding structures, which impart superhydrophobic properties. Previous research has shown that the superhydrophobic nature of the feet allows mosquitoes to land on water, which is necessary for their reproduction cycle. Read More

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July 2017
22 Reads

Parasitic diseases of camels in Iran (1931-2017) - a literature review.

Parasite 2017 15;24:21. Epub 2017 Jun 15.

Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Parasitic diseases of camels are major causes of impaired milk and meat production, decreases in performance or even death. Some camel parasites also represent a threat to human health. About 171,500 one-humped camels (Camelus dromedarius) and 100-300 two-humped camels (Camelus bactrianus) live in Iran. Read More

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April 2018
17 Reads

Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep.

BMC Vet Res 2017 May 30;13(1):148. Epub 2017 May 30.

Merial GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany.

Background: The anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined. Read More

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May 2017
21 Reads

Functional genomics in reveal diverse muscle nAChRs and differences between cholinergic anthelmintics.

Proc Natl Acad Sci U S A 2017 05 9;114(21):5539-5544. Epub 2017 May 9.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011

Many techniques for studying functional genomics of important target sites of anthelmintics have been restricted to because they have failed when applied to animal parasites. To overcome these limitations, we have focused our research on the human nematode parasite which causes elephantiasis. Here, we combine single-cell PCR, whole muscle cell patch clamp, motility phenotyping (Worminator), and dsRNA for RNAi for functional genomic studies that have revealed, in vivo, four different muscle nAChRs ( and ). Read More

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May 2017
2 Reads

Corrigendum to "Cross reactive molecules of human lymphatic filaria Brugia malayi inhibit Leishmania donovani infection in hamsters" [Acta Trop. 152 (2015) 103-111].

Acta Trop 2017 08 26;172:263. Epub 2017 Apr 26.

Division of Parasitology, CSIR-Central Drug Research Institute, New Campus, BS 10/1, Sector 10, Jankipuram Extension, Lucknow 226031, India. Electronic address:

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August 2017
5 Reads

Lessons from the genomes and transcriptomes of filarial nematodes.

Mol Biochem Parasitol 2017 07 23;215:23-29. Epub 2017 Jan 23.

Center for Genomics and Systems Biology, Department of Biology, New York University, USA. Electronic address:

Human filarial infections are a leading cause of morbidity in the developing world. While a small arsenal of drugs exists to treat these infections, there remains a tremendous need for the development of additional interventions. Recent genome sequences and transcriptome analyses of filarial nematodes have provided novel biological insight and allowed for the prediction of novel drug targets as well as potential vaccine candidates. Read More

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July 2017
1 Read

Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia.

Parasit Vectors 2017 01 24;10(1):40. Epub 2017 Jan 24.

Division of Parasitology, CSIR-Central Drug Research Institute, BS 10/1, Sector 10 Jankipuram Extension, Sitapur Road, Lucknow, UP, 226031, India.

Background: In the past, immune responses to several Brugia malayi immunodominant antigens have been characterized in filaria-infected populations; however, little is known regarding Wolbachia proteins. We earlier cloned and characterized few B. malayi (trehalose-6-phosphate phosphatase, Bm-TPP and heavy chain myosin, BmAF-Myo) and Wolbachia (translation initiation factor-1, Wol Tl IF-1 and NAD-dependent DNA ligase, wBm-LigA) proteins and investigated the immune responses, which they triggered in animal models. Read More

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January 2017
4 Reads
3.430 Impact Factor

Characterization of immunoreactive proteins of Setaria cervi isolated by preparative polyacrylamide gel electrophoresis.

Acta Parasitol 2017 Mar;62(1):29-37

Filarial parasites are complex mixtures of antigenic proteins and characterization of these antigenic molecules is essential to identify the diagnostically important filaria-specific antigens. In the present study, we have fractionated the somatic extracts from adults of Setaria cervi (bovine filarial parasite) on preparative SDS-polyacrylamide gel electrophoresis and tested the immunoreactivity of the separated gel fractions with polyclonal antibodies against filarial excretory-secretory antigens as well as filarial patients sera. The SDS-PAGE analysis of gel eluted fractions revealed 1 protein band in F-1 fraction, 2 protein bands in F-2 fraction and 2-3 protein bands in all other fractions (F3- F11). Read More

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March 2017
1 Read
0.960 Impact Factor

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae.

Sci Rep 2016 12 22;6:39648. Epub 2016 Dec 22.

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae contain Wolbachia endobacteria that synthesize the MDP-containing cell wall precursor lipid II, NOD2's role during infection with the rodent filaria Litomosoides sigmodontis was investigated. In NFκB reporter-cells, worm-extract containing Wolbachia induced NOD2 and NOD1. Read More

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December 2016
15 Reads

Immunization with Brugia malayi Myosin as Heterologous DNA Prime Protein Boost Induces Protective Immunity against B. malayi Infection in Mastomys coucha.

PLoS One 2016 9;11(11):e0164991. Epub 2016 Nov 9.

Division of Parasitology, CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.

The current control strategies employing chemotherapy with diethylcarbamazine, ivermectin and albendazole have reduced transmission in some filaria-endemic areas, there is growing interest for complementary approaches, such as vaccines especially in light of threat of parasite developing resistance to mainstay drugs. We earlier demonstrated recombinant heavy chain myosin of B. malayi (Bm-Myo) as a potent vaccine candidate whose efficacy was enhanced by heterologous DNA prime/protein boost (Myo-pcD+Bm-Myo) vaccination in BALB/c mice. Read More

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July 2017
18 Reads
1 Citation
3.234 Impact Factor

Increased IgG antibody responses to excretory/secretory antigens in neonates born from mothers infected with filarial nematodes.

J Helminthol 2017 Nov 28;91(6):752-756. Epub 2016 Oct 28.

Division of Immunology,Regional Medical Research Center (Indian Council of Medical Research),Chandrasekharpur,Bhubaneswar - 751023,Odisha,India.

The present investigation aimed to evaluate the extent to which maternal filarial infection influences IgG subclass immune responses in the cord blood of neonates. Prevalence of antigenaemia was detected using an Og4C3 assay. Filaria-specific IgG subclasses against excretory/secretory antigens were measured by ELISA. Read More

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November 2017
3 Reads

Filarial nematode infection in eclectus parrots (Eclectus roratus) in Taiwan.

Avian Pathol 2017 Apr 20;46(2):188-194. Epub 2016 Dec 20.

a Department of Veterinary Medicine and Animal Hospital , College of Veterinary Medicine, National Pingtung University of Science and Technology , Pingtung , Taiwan (ROC).

A total of 166 psittacines belonging to 22 species were received by the Animal Hospital of National Pingtung University of Science & Technology (NPUST) from 2013 to 2015. Only eclectus parrots (Eclectus roratus) were identified as hosts for microfilariae. All eclectus parrots were adult birds and had been kept in Taiwan for more than three years. Read More

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April 2017
2 Reads

Prevalence and pathogenesis of some filarial nematodes infecting donkeys in Egypt.

Vet World 2016 Aug 22;9(8):888-92. Epub 2016 Aug 22.

Department of Parasitology, Faculty of Veterinary Medicine, Banha University, Moshtohor, Toukh 13736, Egypt.

Aim: The primary objective of the present study is to determine the commonness of filarial parasites in donkeys in Egypt, identification of the filarial species tainting them and the delivered pathogenic impact connected with the infestation.

Materials And Methods: A total of 188 donkeys were examined for filarial infection. The blood samples and scraping of the cutaneous bleeding lesions were collected, stained, and inspected for microfilariae all through the period from March 2011 to October 2013. Read More

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August 2016
1 Read

Filarial worm residing in ovarian papillary serous adenocarcinoma-A rare case report.

Diagn Cytopathol 2016 Nov 22;44(11):952-954. Epub 2016 Jul 22.

Department of Gynecology, Lok Nayak Hospital, Delhi, India.

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November 2016
5 Reads

Finding Wolbachia in Filarial larvae and Culicidae Mosquitoes in Upper Egypt Governorate.

Korean J Parasitol 2016 Jun 30;54(3):265-72. Epub 2016 Jun 30.

Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Wolbachia is an obligatory intracellular endosymbiotic bacterium, present in over 20% of all insects altering insect reproductive capabilities and in a wide range of filarial worms which is essential for worm survival and reproduction. In Egypt, no available data were found about Wolbachia searching for it in either mosquitoes or filarial worms. Thus, we aimed to identify the possible concurrent presence of Wolbachia within different mosquitoes and filarial parasites, in Assiut Governorate, Egypt using multiplex PCR. Read More

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June 2016
2 Reads

Mapping is a prerequisite for elimination of filariasis and effective targeting of filarial 'hot spots'.

Pathog Glob Health 2016 Jun-Jul;110(4-5):157-63. Epub 2016 Jul 14.

b Department of Epidemiology and Vector Control , National Institute for Research in Tribal Health (ICMR) , Jabalpur , India.

Objective: This study was undertaken to determine the prevalence of filarial infection in the districts of Madhya Pradesh, which were classified as non-endemic by the national program for control of filariasis. These districts showed evidence of clinical symptoms related to filariasis. To confirm the presence of filariasis, night blood surveys and entomological surveys were carried out to detect microfilaria in humans and filarial infection in vectors. Read More

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April 2017
8 Reads

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria.

Planta Med 2017 Feb 8;83(3-04):300-305. Epub 2016 Jul 8.

School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

A new chromone, 2-(2-hydroxy-2-phenylethyl)chromone (), was isolated together with ten known phenylethyl chromones from MeOH extracts of agarwood (). The selected compounds were evaluated in an antiproliferative assay against five human tumor cell lines, including a multidrug-resistant cell line. They were also tested for antitumor promoting activity, as mediated by 12--tetradecanoylphorbol-13-acetate-induced activation of the Epstein-Barr virus early antigen in Raji cells. Read More

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February 2017
11 Reads

Identifying role of perceived quality and satisfaction on the utilization status of the community clinic services; Bangladesh context.

BMC Health Serv Res 2016 06 24;16:204. Epub 2016 Jun 24.

Department of Maternal and Child Health, National Institute of Preventive and Social Medicine (NIPSOM), Mohakhali, Dhaka, 1212, Bangladesh.

Background: Bangladesh is one among the few countries of the world that provides free medical services at the community level through various public health facilities. It is now evident that, clients' perceived quality of services and their expectations of service standards affect health service utilization to a great extent. The aim of the study was to develop and validate the measures for perception and satisfaction of primary health care quality in Bangladesh context and to identify their aspects on the utilization status of the Community Clinic services. Read More

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June 2016
12 Reads
1.660 Impact Factor

Mobile Diagnostics Based on Motion? A Close Look at Motility Patterns in the Schistosome Life Cycle.

Diagnostics (Basel) 2016 Jun 17;6(2). Epub 2016 Jun 17.

Public Health Agency of Sweden, SE-17182 Solna, Sweden.

Imaging at high resolution and subsequent image analysis with modified mobile phones have the potential to solve problems related to microscopy-based diagnostics of parasitic infections in many endemic regions. Diagnostics using the computing power of "smartphones" is not restricted by limited expertise or limitations set by visual perception of a microscopist. Thus diagnostics currently almost exclusively dependent on recognition of morphological features of pathogenic organisms could be based on additional properties, such as motility characteristics recognizable by computer vision. Read More

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Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens.

Am J Trop Med Hyg 2016 08 6;95(2):394-400. Epub 2016 Jun 6.

Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.

Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. Read More

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August 2016
14 Reads
2 Citations
2.700 Impact Factor

Occurrence of Mansonella ozzardi diagnosed using a polycarbonate membrane in a riverside population of Lábrea in the Western Brazilian Amazon.

Rev Soc Bras Med Trop 2016 Feb;49(1):115-8

Departamento de Medicina, Faculdade São Lucas, Porto Velho, Rondônia, Brazil.

INTRODUCTION Mansonella ozzardi is a widely distributed filaria worm in the Amazon region. This study aimed to determine the prevalence of M. ozzardi infection in riverine communities of Lábrea municipality, Amazonas State, Brazil. Read More

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February 2016
1 Read

Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports).

BMC Infect Dis 2016 Apr 19;16:171. Epub 2016 Apr 19.

Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.

Background: Human dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time. Read More

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April 2016
5 Reads

Pyrosequencing Using SL and 5S rRNA as Molecular Markers for Identifying Zoonotic Filarial Nematodes in Blood Samples and Mosquitoes.

Vector Borne Zoonotic Dis 2016 05 23;16(5):326-33. Epub 2016 Mar 23.

1 Department of Parasitology, Faculty of Medicine, Khon Kaen University , Khon Kaen, Thailand .

Backgrounds: Lymphatic filariasis is principally caused by Wuchereria bancrofti, and Brugia malayi. The other two filarial nematode species, Brugia pahangi and Dirofilaria immitis, possibly cause human zoonotic diseases.

Methods: We propose the development of a PCR assay linked with DNA pyrosequencing as a rapid tool to identify W. Read More

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May 2016
23 Reads
2.298 Impact Factor

First report of Filaria martis Gmelin, 1790 in the European mink, Mustela lutreola (Linnaeus, 1761).

Parasitol Res 2016 Jun 23;115(6):2499-503. Epub 2016 Mar 23.

GREGE, Route de Préchac, 33730, Villandraut, France.

The riparian European mink (Mustela lutreola), currently surviving in only three unconnected sites in Europe, is now listed as a critically endangered species according to the IUCN. Habitat loss and degradation, anthropic mortality, interaction with the feral American mink (Neovison vison), and infectious diseases are among the principal causes of its decline. Surveys of helminth parasites of this host that also include focus on subcutaneous potentially pathogenic helminths such as those belonging to the genus Filaria are very scarce. Read More

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June 2016
2 Reads

Can community-based integrated vector control hasten the process of LF elimination?

Parasitol Res 2016 Jun 12;115(6):2353-62. Epub 2016 Mar 12.

Centre for Research in Medical Entomology (ICMR), No. 4 Sarojini Street, Chinna Chokkikulam, Madurai, 625 002, Tamil Nadu, India.

Community-based integrated vector control (IVC) using polystyrene beads (EPS) and pyrethroid impregnated curtains (PIC) as an adjunct to mass drug administration (MDA) was implemented for lymphatic filariasis elimination, in the filaria endemic villages of Tirukoilur, south India. In all the villages, MDA was carried out by the state health machinery, as part of the national filariasis elimination programme. Thirty-six difficult-to-control villages were grouped as, viz, MDA alone, MDA + EPS and MDA + EPS + PIC arms. Read More

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June 2016
2 Reads