143 results match your criteria Fibrous Papule of the Face


Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex.

Orphanet J Rare Dis 2020 Jun 1;15(1):133. Epub 2020 Jun 1.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder forming hamartomas throughout the body. Facial angiofibromas (FAs) occur in 75% of TSC patients, which are often enlarged, impairing the appearance of the face, and reducing the patient's quality of life (QOL). The aim of this study was to characterize the impact of topical sirolimus treatment on the health-related QOL in patients with FA associated with TSC. Read More

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http://dx.doi.org/10.1186/s13023-020-01417-5DOI Listing

The role of diagnostic and interventional radiology in juvenile nasopharyngeal angiofibroma: A case report and literature review.

Radiol Case Rep 2020 Jul 22;15(7):812-815. Epub 2020 Apr 22.

Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Juvenile Nasopharyngeal Angiofibroma is a rare and locally aggressive benign tumor. It is characterized by high vascularization leading to spontaneous bleeding or massive hemorrhage. We reported a case of 13 years old boy with a swollen at the right face, nasal congestion, recurrent nose bleeding, hyposmia, headache, breathing difficulty, and a nasopharyngeal mass at CT scan. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182694PMC

The efficacy and safety of topical rapamycin-calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double-blind, randomized clinical trial.

Br J Dermatol 2020 Feb 16. Epub 2020 Feb 16.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The efficacy of topical rapamycin is well documented for tuberous sclerosis complex (TSC)-related facial angiofibromas (FAs). Calcitriol has been shown to lessen skin fibrosis and may be therapeutically beneficial to FAs.

Objectives: To evaluate whether topical rapamycin-calcitriol combination is an effective and safe treatment for TSC-related FAs. Read More

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http://dx.doi.org/10.1111/bjd.18949DOI Listing
February 2020

Scleromyxedema histopathologically mimicking hypercellular fibrous papules (angiofibomas): Case report of an unusual histopathological presentation.

J Cutan Pathol 2020 Feb 12. Epub 2020 Feb 12.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York.

Scleromyxedema (SMX) is an inflammatory condition of unknown etiology strongly associated with monoclonal gammopathy. Classical histopathology of SMX is characterized with the triad of diffuse mucin deposits, increased amount of collagen, and presence of stellate fibroblasts. Herein, we report an unusual histopathological variant of SMX in a 41-year-old female with lesions of the nose histopathologically mimicking cellular angiofibromas. Read More

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http://dx.doi.org/10.1111/cup.13665DOI Listing
February 2020

[Primary juvenile nasal angiofibroma in a 38 year-old male (case report)].

Vestn Otorinolaringol 2019 ;84(5):76-80

N.N. Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia, 125047.

Juvenile nasal angiofibroma (JNA) is a benign, fibro-vascular, locally aggressive tumor with invasive growth patterns and high probability of recurrence. JNA present exclusively in adolescent boys between 9 and 19 years of age, total about 0.05% of head and neck tumors. Read More

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http://dx.doi.org/10.17116/otorino20198405176DOI Listing
January 2020

Clinical and histopathological presentation and successful treatment with ciclosporin for canine sarcoidosis: a case report.

Vet Dermatol 2019 Oct 22;30(5):438-e136. Epub 2019 Jul 22.

Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, 252-5201, Japan.

Background: Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis is a rare disease which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face and ear; it is usually treated with corticosteroids. To date, there are no published reports on alternatives to corticosteroids treatment. Read More

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http://dx.doi.org/10.1111/vde.12775DOI Listing
October 2019
5 Reads

Extranasopharyngeal Angiofibroma of the Frontal Sinus.

J Craniofac Surg 2019 Jul;30(5):e432-e433

Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea.

Angiofibroma is a rare tumor that accounts for about 0.05% of all head and neck tumors; it mainly occurs in the region of the nasopharynx. To date, no study originating in the frontal sinus has been reported. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005464DOI Listing
July 2019
3 Reads

Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a Single-Center, Open-Label Trial.

Child Neurol Open 2019 14;6:2329048X19835047. Epub 2019 Apr 14.

Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Facial angiofibromas, composed of fibrous tissue and blood vessels appearing on the face, are closely associated with tuberous sclerosis complex. Historically, oral rapamycin, a mammalian target of the rapamycin inhibitor of cell proliferation, has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine generally precludes its use in patients lacking significant internal involvement. The authors developed a novel topical formulation of rapamycin cream to treat the facial angiofibroma without exposing patients to possible systemic side effects. Read More

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http://dx.doi.org/10.1177/2329048X19835047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589944PMC
April 2019
8 Reads

Angiofibroma of the Eyelid: A Rare Clinical and Histologic Variant.

Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e199-e102

Departments of Ophthalmology.

A flesh-colored, supraciliary lesion of the left upper eyelid in a 47-year-old man was excised for cosmetic reasons. Histopathology and immunohistochemistry demonstrated CD34-positive benign spindle cells, factor XIIIa-positive dendritic cells, and CD163-positive histiocytes, all dispersed within a diffuse collagenous background. Prominent loose perivascular cuffs of fibroblastic cells and collagen surrounded small blood vessels. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001423DOI Listing
December 2019
24 Reads

Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions.

J Craniofac Surg 2019 May/Jun;30(3):800-802

Department of Otolaryngology - Head and Neck Surgery.

Lesions involving the masseteric and buccal spaces have traditionally required transoral or transcervical approaches. Herein, the authors describe the successful endonasal endoscopic resection of a juvenile nasopharyngeal angiofibroma (JNA) with significant extension into the masseteric and buccal spaces facilitated by transoral finger retraction. Juvenile nasopharyngeal angiofibromas are hypervascular tumors originating in the pterygopalatine fossa (PPF) with complex relationships to skull base and orbital structures. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004931DOI Listing
July 2019
11 Reads

Intraoral Endoscopic Ligation of Maxillary Artery in the Infratemporal Fossa.

J Craniofac Surg 2019 Jan;30(1):137-140

Department of Otolaryngology - Head and Neck Surgery, Endoscopic Sinus Surgery and Skull Base Surgery, Autonomous University of Veracruz, Xalapa, Mexico.

Ligation of the sphenopalatine and posterior nasal arteries is indicated for posterior epistaxis as initial treatment or when conservative measures fail. In some patients, a transnasal approach or its alternative transantral approach are not possible due to tumor filling the nasal corridor, pterygopalatine fossa, or maxillary sinus. Aim of this study was to evaluate feasibility of endoscopically assisted transoral approach for the ligation of the maxillary artery (MA). Read More

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http://dx.doi.org/10.1097/SCS.0000000000004981DOI Listing
January 2019
49 Reads

Long-term neurological morbidity following endoscopic transnasal resection of juvenile angiofibroma.

Laryngoscope 2019 09 12;129(9):2184-2188. Epub 2018 Oct 12.

Unit of Otorhinolaryngology-Head and Neck Surgery.

Objectives/hypothesis: Although transnasal endoscopic resection (TER) of juvenile angiofibroma (JA) is unquestionably less invasive than traditional external approaches, several endonasal and neurovascular structures are sacrificed during the procedure. The aim of this study was to evaluate long-term neurological morbidity and related quality of life following TER of JA.

Study Design: Retrospective cohort study. Read More

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http://doi.wiley.com/10.1002/lary.27466
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http://dx.doi.org/10.1002/lary.27466DOI Listing
September 2019
11 Reads

The cutaneous manifestations of tuberous sclerosis complex.

Am J Med Genet C Semin Med Genet 2018 09 23;178(3):321-325. Epub 2018 Sep 23.

Department of Dermatology, UTHealth McGovern Medical School, Houston, Texas.

Tuberous sclerosis complex (TSC) is a genetic multisystem disease with variable manifestations that can prominently involve the skin. The diagnosis of this disorder has evolved over the past two centuries. The 2012 TSC criteria emphasizes the importance of dermatological findings; orocutaneous manifestations account for 4 of 11 major criterion and 3 of 6 minor criterion. Read More

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http://doi.wiley.com/10.1002/ajmg.c.31649
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http://dx.doi.org/10.1002/ajmg.c.31649DOI Listing
September 2018
5 Reads

Facial angiofibromas treated by rapamycin 0.05% ointment and a combined laser therapy.

J Cosmet Dermatol 2018 Oct 19;17(5):762-765. Epub 2018 Aug 19.

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

Background: Tuberous sclerosis is an autosomal dominant genodermatosis characterized by nonmalignant hamartomas in multiple organs. Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement. Facial disfigurement negatively affects the quality of life of patients and their families, often leading to negative psychosocial outcomes. Read More

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http://doi.wiley.com/10.1111/jocd.12725
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http://dx.doi.org/10.1111/jocd.12725DOI Listing
October 2018
28 Reads

Pediatric Nasal Obstruction.

Otolaryngol Clin North Am 2018 Oct 19;51(5):971-985. Epub 2018 Jul 19.

Department of Otolaryngology, Upper Airway Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2018, Cincinnati, OH 45229, USA; Department of Pulmonary Medicine, Upper Airway Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2018, Cincinnati, OH 45229, USA. Electronic address:

Nasal obstruction is one of the most common problems seen by pediatric otolaryngologists. Prompt treatment of nasal obstruction can be critical in newborns and infants because of their obligatory nasal breathing. Older children will typically have more inflammatory, infectious, or traumatic causes of nasal obstruction. Read More

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http://dx.doi.org/10.1016/j.otc.2018.05.005DOI Listing
October 2018
63 Reads

Fibrous Papule: A Histopathologic Review.

Am J Dermatopathol 2018 Aug;40(8):551-560

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Fibrous papule (FP) is a common benign lesion located primarily in the nose. Although its histogenesis has been marred with controversies in the past, the dermal dendrocyte is now largely accepted to be the putative cell of origin. Histopathologic diagnosis of an FP is straightforward in most cases, which shows characteristics of an angiofibroma. Read More

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http://Insights.ovid.com/crossref?an=00000372-201808000-0000
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http://dx.doi.org/10.1097/DAD.0000000000001083DOI Listing
August 2018
16 Reads

Calvian Endo-pen: New Coagulation Forceps for Endoscopic Endonasal Transsphenoidal Surgery.

J Neurol Surg A Cent Eur Neurosurg 2018 Nov 6;79(6):524-527. Epub 2018 Jul 6.

Department of ENT, HELIOS Klinikum Erfurt, Erfurt, Thüringen, Germany.

Objective:  Over the past few years bipolar electrocoagulation techniques in neurosurgery have been continually improving. However, limited access during endoscopic endonasal transsphenoidal surgery (EETS) for central skull base pathologies and the requirement of very precise coagulation in that dedicated anatomical area requires further refinement of bipolar coagulation instruments. We describe our experience (effectiveness of coagulation, intraoperative handling, and the use as a dissecting tool) with a new type of coagulation forceps, the Calvian endo-pen (Sutter Medizintechnik, Freiburg, Germany) during EETS. Read More

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http://dx.doi.org/10.1055/s-0038-1655731DOI Listing
November 2018
6 Reads

Cutaneous Manifestations of Tuberous Sclerosis.

Acta Dermatovenerol Croat 2018 Apr;26(1):73-74

Vladimir Prelević, MD, Clinic for Nephrology Clinical Center of Montenegro, Ljubljanska bb 81101 Podgorica, Montenegro;

Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). Read More

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April 2018
47 Reads

Bilateral Giant Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Complex: A Case Report.

Acta Med Indones 2018 Jan;50(1):61-65

Department of Surgery, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.

Tuberous sclerosis complex (TSC) has several renal manifestations including angiomyolipomas (AML) and renal epithelial neoplasms. A bilateral giant renal AML is extremely rare. We report a case of giant bilateral AML and discuss the diagnosis and treatment of it. Read More

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January 2018
11 Reads

Masses of the Nose, Nasal Cavity, and Nasopharynx in Children.

Radiographics 2017 Oct;37(6):1704-1730

From the Department of Radiology, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205 (D.P.R.); and Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio (E.S.O., B.L.K.).

A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. Read More

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http://dx.doi.org/10.1148/rg.2017170064DOI Listing
October 2017
80 Reads

Tuberous Sclerosis Complex in 29 Children: Clinical and Genetic Analysis and Facial Angiofibroma Responses to Topical Sirolimus.

Pediatr Dermatol 2017 Sep 2;34(5):572-577. Epub 2017 Aug 2.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background/objectives: Tuberous sclerosis complex (TSC) is a genetic disorder and facial angiofibromas are disfiguring facial lesions. The aim of this study was to analyze the clinical and genetic features of TSC and to assess the treatment of facial angiofibromas using topical sirolimus in Chinese children.

Methods: Information was collected on 29 patients with TSC. Read More

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http://dx.doi.org/10.1111/pde.13204DOI Listing
September 2017
62 Reads

Nasopharyngeal angiofibroma in an adult with Proteus syndrome. First reported case.

Hippokratia 2017 Jul-Sep;21(3):147-149

2 Otolaryngology Department, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece.

Background: Proteus Syndrome (PS) is a rare hamartoneoplastic disorder consisting of a disproportionate and asymmetric overgrowth of body parts, leading to severe body and face disfigurement. Individuals with PS frequently need to undergo a number of surgical procedures including Otolaryngology interventions. Their peculiar anatomy turns even the most straightforward intervention to a challenging one. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247999PMC
November 2018
33 Reads

Tuberous Sclerosis Complex.

N Engl J Med 2017 May;376(20):e42

Universita degli Studi di Pisa, Pisa, Italy

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http://dx.doi.org/10.1056/NEJMicm1610501DOI Listing
May 2017
13 Reads

Reflectance confocal microscopy features of facial angiofibromas.

Dermatol Pract Concept 2017 Jan 31;7(1):51-54. Epub 2017 Jan 31.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.

Facial angiofibromas are benign tumors presenting as firm, dome-shaped, flesh-colored to pink papules, typically on the nose and adjoining central face. Clinically and dermoscopically they can mimic melanocytic nevi or basal cell carcinomas (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that is useful in diagnosing melanocytic and non-melanocytic facial lesions. Read More

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http://dx.doi.org/10.5826/dpc.0701a10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315042PMC
January 2017
8 Reads

Erythematous Lesions on the Face and Papules on the Trunk of a Young Woman.

Actas Dermosifiliogr 2017 Dec 21;108(10):941-942. Epub 2017 Jan 21.

Servicio de Dermatología, Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, España.

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http://dx.doi.org/10.1016/j.ad.2016.07.024DOI Listing
December 2017
6 Reads

Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face.

An Bras Dermatol 2016 Sep-Oct;91(5):589-594

Universidade Federal da Bahia (UFBA) - Salvador (BA), Brazil.

Background:: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature.

Objective:: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions.

Methods:: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20165077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087215PMC
May 2017
18 Reads

Bilateral blindness following anterior nasal packing in a case of nasopharyngeal angiofibroma.

J Laryngol Otol 2016 Nov;130(11):1072-1073

ENT Department,All India Institute of Medical Sciences,Bhubaneswar,Odisha,India.

Background: Epistaxis is the most common ENT emergency encountered in the Emergency Department. Most cases can be managed by simple anterior nasal packing. This is usually a safe and very effective option in an emergency situation, requiring minimal expertise and infrastructure. Read More

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http://www.journals.cambridge.org/abstract_S0022215116008987
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http://dx.doi.org/10.1017/S0022215116008987DOI Listing
November 2016
5 Reads

Tuberous Sclerosis with Severe Cutaneous Manifestation and Multiples Facial Angiofibromas.

Head Neck Pathol 2016 Dec 2;10(4):542-546. Epub 2016 May 2.

Department of Clinic and Surgery, Area Stomatology, Alfenas Federal University, Alfenas, Minas Gerais, Brazil.

Tuberous sclerosis is an extremely variable disease that can affect virtually any organ in the body. The most common findings are cutaneous manifestations, that are critical features in helping to establish diagnosis. We present a case of young man with diagnosis of tuberous sclerosis presenting multiple shagreen patches around the trunk, in the neck and genital region; large plaques with uneven surfaces on the right side of the lower back; and multiple papular lesions in his face, particularly around the nasolabial region, eyebrows and forehead. Read More

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http://dx.doi.org/10.1007/s12105-016-0723-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082047PMC
December 2016
14 Reads

Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis.

Indian J Dermatol Venereol Leprol 2017 Jan-Feb;83(1):27-32

Department of Pediatric Neurology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Background: The skin is one of the most affected organs in tuberous sclerosis complex and angiofibromas are seen in almost 80% of such patients. These benign tumors impose a great psycho-social burden on patients.

Objective: The aim of the study was to evaluate the effectiveness and tolerability of topical sirolimus for facial angiofibromas in patients with tuberous sclerosis complex. Read More

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http://dx.doi.org/10.4103/0378-6323.190844DOI Listing
May 2017
18 Reads

Angiofibroma of Soft Tissue on the Cheek: Diagnosis Confirmed by Gene Rearrangement in NCOA2.

Acta Derm Venereol 2017 01;97(1):133-134

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

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http://dx.doi.org/10.2340/00015555-2461DOI Listing
January 2017
24 Reads

Avoiding allogenic blood transfusions in endoscopic angiofibroma surgery.

J Otolaryngol Head Neck Surg 2016 Apr 11;45:25. Epub 2016 Apr 11.

Division of Otolaryngology, University of Cape Town, Cape Town, South Africa.

Background: Surgical approaches for many tumours are often limited by blood loss, exposure and risk to vital anatomical structures. Therefore, the standard of care for certain skull base tumours has become endoscopic transnasal resection. Other surgical disciplines often use cell salvage techniques, but review of the otolaryngology literature revealed very few case reports. Read More

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http://dx.doi.org/10.1186/s40463-016-0135-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827172PMC
April 2016
8 Reads

Tuberous sclerosis: histological analysis with confocal laser scanning microscope of gingival angiofibromatosis.

Pathologica 2015 Sep-Dec;107(3-4):197-200

Introduction: Tuberous sclerosis (TS) is an autosomal dominant neuro-cutaneous syndrome characterized by multiple hamartomas in various organs, especially on skin and central nervous system. The most common features of TS include facial angiofibromas, hypomelanotic cutaneous macules, shagreen patches in the lumbar area, cerebral cortical tubers, sub-ependymal nodules, sub-ependymal giant cell astrocytomas, cardiac rhabdomyomas, and renal angiomyolipomas. Frequently oral manifestations such as fibrous hyperplasia, angiofibromas and dental enamel pitting are also observed. Read More

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April 2016
4 Reads

A fibrous papule with abundant CD34-immunoreactive ganglion-like multinucleated giant cells: a case report and review of the literature.

Dermatol Online J 2015 Jul 15;21(7). Epub 2015 Jul 15.

Stanford University School of Medicine.

Fibrous papules present clinically as benign, asymptomatic, dome-shaped, flesh colored papules on the face. Histologically, fibrous papules are characterized by fibrous stroma with fibroblasts and dilated blood vessels. Multiple variants of fibrous papules have been reported. Read More

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http://escholarship.org/uc/item/1bd989kn.pdf
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July 2015
8 Reads

Inhibition of Angiofibromas in a Tuberous Sclerosis Patient Using Topical Timolol 0.5% Gel.

Pediatrics 2015 Sep;136(3):e709-13

Angiofibromas are the most recognized cutaneous manifestations of tuberous sclerosis complex. Angiofibromas can be associated with disfigurement, bleeding, pruritus, and erythema and may lead to significant psychosocial consequences for affected patients. Histopathologically, angiofibromas consist of a mixture of vascular and interstitial cells. Read More

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http://pediatrics.aappublications.org/content/pediatrics/136
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2015-0025DOI Listing
September 2015
8 Reads

Stage III nasopharyngeal angiofibroma: Improving results with endoscopic-assisted midfacial degloving and modification to the Fisch staging system.

J Craniomaxillofac Surg 2015 Oct 31;43(8):1678-83. Epub 2015 Jul 31.

Department of Neurosurgery, (Head of Dept: Prof. Sanjay Behari), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

Objectives: To study outcomes with endoscopic-assisted midfacial degloving for Fisch stage III nasopharyngeal angiofibroma and propose a new staging system.

Design: Retrospective study of patients with Fisch stage III juvenile nasopharyngeal angiofibroma (JNA) including preoperative angiography, intraoperative blood loss and residue/recurrence following surgery.

Setting: Tertiary care superspecialty referral center. Read More

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http://dx.doi.org/10.1016/j.jcms.2015.07.025DOI Listing
October 2015
49 Reads
2.600 Impact Factor

Facial Angiofibromas.

Indian Pediatr 2015 Jul;52(7):634

Departments of Pediatric Medicine and #Dermatology, North Bengal Medical College; and *Dermatology, RG Kar Medical College; Kolkata, West Bengal, India.

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July 2015
47 Reads

Fibrous forehead plaque.

Cutis 2015 Apr;95(4):E11-6

Graduate Medical Education, Broward Health Medical Center, 1600 S Andrews Ave, Fort Lauderdale, FL 33316, USA.

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April 2015
18 Reads

Juvenile Nasopharyngeal Angiofibroma: Case report with review on role of imaging in diagnosis.

Contemp Clin Dent 2015 Jan-Mar;6(1):98-102

Department of Radio Diagnosis, GB Pant Hospital, New Delhi, India.

Juvenile nasopharyngeal angiofibroma is a locally aggressive benign vascular neoplasm, composed of vasogenic and myofibroblastic elements, accounts for 0.05-0.5% of all the head and neck neoplasms. Read More

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http://www.utmb.edu/otoref/Grnds/angiofibroma-2012-12/angiof
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http://www.jurnalulpediatrului.ro/pages/arhiva/59-60/59-60-I
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https://fhs.mcmaster.ca/otolaryngology/documents/Nov2013rhin
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http://www.contempclindent.org/text.asp?2015/6/1/98/149301
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http://dx.doi.org/10.4103/0976-237X.149301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319355PMC
February 2015
19 Reads

Cutaneous markers of systemic manifestations of tuberous sclerosis complex.

Int J Dermatol 2015 Jan;54(1):e52-5

Department of Dermatology, Colombo South Teaching Hospital, Colombo, Sri Lanka.

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http://dx.doi.org/10.1111/ijd.12636DOI Listing
January 2015
24 Reads

Laser treatment of angiofibromas in tuberous sclerosis.

Minerva Pediatr 2014 Dec;66(6):585-6

Department of Plastic and Reconstructive Surgery Policlinico di Modena, University of Modena & Reggio Emilia, Italy -

Tuberous sclerosis complex is an autosomal dominant disorder that can cause nonmalignant hamartomas in any organ. Angiofibromas are the most disturbing marker of the disease because they are conspicuously present on the face. We report the case of a 15-year-old girl affected by tuberous sclerosis, whose facial angiofibromas were satisfactorily treated by a green light vascular laser (532 nm). Read More

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December 2014
20 Reads

Topical everolimus for facial angiofibromas in the tuberous sclerosis complex. A first case report.

Pediatr Neurol 2014 Jul 1;51(1):109-13. Epub 2014 Mar 1.

Hospital Pharmacy, University Hospital Basel, University of Basel, Basel, Switzerland.

Background: Facial angiofibromas are present in most of the patients with the tuberous sclerosis complex and may cause severe disfiguration of the face. The tumor growth in tuberous sclerosis complex is promoted by the disinhibition of the mammalian target of rapamycin pathway. Thus, the systemic treatment with mammalian target of rapamycin inhibitors such as sirolimus and everolimus has recently been established to treat specific tuberous sclerosis complex-associated lesions. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2014.02.016DOI Listing
July 2014
115 Reads

Scalp fibroma: a rare cutaneous manifestation of tuberous sclerosis.

BMJ Case Rep 2014 Apr 19;2014. Epub 2014 Apr 19.

Department of Neurology, S M S Medical College, Jaipur, Rajasthan, India.

We report a case of a 23-year-old woman with a history of generalised tonic-clonic seizures, reddish brown maculopapular swelling over the face and an enlarging swelling over the scalp. Physical examinations revealed angiofibroma of the face and other typical cutaneous lesions of tuberous sclerosis, for example, shagreen patch and periungual fibroma. Scalp swelling was labelled as fibroma by dermatologists, which was further supported by the histopathological findings. Read More

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http://dx.doi.org/10.1136/bcr-2013-200612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992614PMC
April 2014
20 Reads

[Atypical histiocytoma in a child].

Ann Dermatol Venereol 2014 Apr 17;141(4):279-84. Epub 2014 Feb 17.

Service de dermatologie, hôpital de l'Archet 2, 151, route de Saint-Antoine, 06200 Nice, France.

Background: Histiocytoma (HC) is a very common benign tumour generally seen in the lower limbs of adults, particularly women. There are, however, atypical forms of HC that behave like locally aggressive tumours, occasionally with relapse or even metastasis. Herein we report a case of locally aggressive HC in a child, which, on account of its clinical extension, required seven surgical procedures to achieve complete excision. Read More

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http://dx.doi.org/10.1016/j.annder.2014.01.004DOI Listing
April 2014
18 Reads

Bilateral juvenile nasopharyngeal angiofibroma: report of a case.

Int Forum Allergy Rhinol 2014 Jul 24;4(7):603-6. Epub 2014 Mar 24.

Department of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA.

Background: Juvenile nasopharyngeal angiofibroma (JNA) is the most common benign neoplasm of the nasopharynx. Almost always unilateral on diagnosis, JNAs are locally invasive and may extend across the midline, giving a false bilateral appearance; as such, true bilateral JNA is exceedingly rare. We present a recent case of true bilateral JNA. Read More

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http://dx.doi.org/10.1002/alr.21322DOI Listing
July 2014
18 Reads

Fibrous papule of the face, similar to tuberous sclerosis complex-associated angiofibroma, shows activation of the mammalian target of rapamycin pathway: evidence for a novel therapeutic strategy?

PLoS One 2014 18;9(2):e89467. Epub 2014 Feb 18.

Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan ; Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Fibrous papules of the face are hamartomas characterized by stellate-shaped stromal cells, multinucleated giant cells, and proliferative blood vessels in the dermis. The pathogenesis of fibrous papules remains unclear. There is a striking microscopic resemblance between fibrous papules and tuberous sclerosis complex (TSC)-associated angiofibromas. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928451PMC
October 2014
7 Reads

Rhinophyma in tuberous sclerosis complex: case report with brief review of literature.

GMS Interdiscip Plast Reconstr Surg DGPW 2014 27;3:Doc12. Epub 2014 Nov 27.

Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Germany.

Tuberous sclerosis or tuberous sclerosis complex (TSC) is an autosomal dominant inherited disease characterized by the triad epilepsy, hamartomas (angiofibroma) and reduced intellectual capacity. Phenotype can vary considerably. Almost all patients with TSC have at least one characteristic dermatologic feature. Read More

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http://www.egms.de/en/journals/iprs/2014-3/iprs000053.shtml
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http://dx.doi.org/10.3205/iprs000053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582513PMC
October 2015
14 Reads

[Fibrous papules of the face: a retrospective anatomoclinical study of 283 cases].

Ann Dermatol Venereol 2013 Dec 17;140(12):763-70. Epub 2013 Oct 17.

Service de dermatologie, hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France. Electronic address:

Background: Fibrous papules of the face are frequent benign lesions seen in the nasal and perinasal region. Their clinical aspect is indistinct and the histological signs are sometimes mild or possibly misleading in the case of atypical forms. We carried out a retrospective study of 283 fibrous papules diagnosed at our histology laboratory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638130109
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http://dx.doi.org/10.1016/j.annder.2013.09.163DOI Listing
December 2013
11 Reads

Tuberous sclerosis complex diagnosed from oral lesions.

Sao Paulo Med J 2013 ;131(5):351-5

Universidade Estadual de Montes Claros, Postgraduate Program on Health Sciences, Montes ClarosMinas GeraisBrazil.

Context: Tuberous sclerosis complex (TSC) is a genetic disease in the group known as neurocutaneous syndromes, with dominant autosomal inheritance. It is characterized by skin and adnexal lesions and central and peripheral nervous system tumors, with neurological and psychiatric findings. It may affect the heart, kidneys, eyes, face, bones, lungs, stomach and dentition. Read More

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http://dx.doi.org/10.1590/1516-3180.2013.1315441DOI Listing
October 2014
21 Reads

[Medical indications for laser therapy in dermatology].

Ned Tijdschr Geneeskd 2013 ;157(44):A6662

Sint Franciscus Gasthuis, afd. Dermatologie, Rotterdam.

Laser therapy in dermatology is often associated with cosmetic procedures. However, nowadays laser therapy has become a treatment modality for many dermatological diseases. We present three cases of patients with different dermatological diseases that are highly therapy-resistant. Read More

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June 2014
28 Reads