148 results match your criteria Fibrous Papule of the Face

Masquerading case of a lumpy bumpy face.

JAAD Case Rep 2020 Dec 16;6(12):1261-1263. Epub 2020 Oct 16.

HCA Healthcare/USF Morsani College of Medicine GME: Largo Medical Center, Largo, Florida.

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December 2020

Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face.

J Cutan Pathol 2021 Feb 2;48(2):274-280. Epub 2020 Dec 2.

Department of Pathology, Acıbadem University School of Medicine, Istanbul, Turkey.

Background: Signs of inflammation including epidermal interface changes, spongiosis, and dermal inflammation as well as pagetoid dyskeratosis are rarely described in fibrous papule (FP). We aimed to describe the inflammatory parameters, the rate of pagetoid dyskeratosis, along with CD163 immunohistochemical staining as an adjunctive diagnostic tool in FP.

Methods: Histopathology samples of all biopsy-proven FP cases were retrieved from archives and investigated for inflammatory parameters, presence of pagetoid dyskeratosis, as well as CD163, CD10, and CD34 immunostaining pattern of dermal spindle/stellate or multinucleate cells (graded from 0 to 4). Read More

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February 2021

The "bumpy" adolescent nose: Acne associated angiofibroma-like nasal papules.

Pediatr Dermatol 2021 Jan 7;38(1):45-49. Epub 2020 Aug 7.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.

Background/objective: Papular scars are a recently described clinical phenotype of acne scarring characterized by papules occurring on the nose and chin. We have observed a similar presentation of nasal papules among patients seen in our clinic for acne and sought to further characterize the clinical and histopathological characteristics of this entity.

Methods: In this single-site case series, a retrospective review of electronic medical records of patients with nasal papules in association with acne vulgaris between April 2018 and April 2019 was performed. Read More

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January 2021

Improved health-related quality of life in patients treated with topical sirolimus for facial angiofibroma associated with tuberous sclerosis complex.

Orphanet J Rare Dis 2020 06 1;15(1):133. Epub 2020 Jun 1.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder forming hamartomas throughout the body. Facial angiofibromas (FAs) occur in 75% of TSC patients, which are often enlarged, impairing the appearance of the face, and reducing the patient's quality of life (QOL). The aim of this study was to characterize the impact of topical sirolimus treatment on the health-related QOL in patients with FA associated with TSC. Read More

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The role of diagnostic and interventional radiology in juvenile nasopharyngeal angiofibroma: A case report and literature review.

Radiol Case Rep 2020 Jul 22;15(7):812-815. Epub 2020 Apr 22.

Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Juvenile Nasopharyngeal Angiofibroma is a rare and locally aggressive benign tumor. It is characterized by high vascularization leading to spontaneous bleeding or massive hemorrhage. We reported a case of 13 years old boy with a swollen at the right face, nasal congestion, recurrent nose bleeding, hyposmia, headache, breathing difficulty, and a nasopharyngeal mass at CT scan. Read More

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The efficacy and safety of topical rapamycin-calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double-blind, randomized clinical trial.

Br J Dermatol 2020 10 18;183(4):655-663. Epub 2020 Mar 18.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: The efficacy of topical rapamycin is well documented for tuberous sclerosis complex (TSC)-related facial angiofibromas (FAs). Calcitriol has been shown to lessen skin fibrosis and may be therapeutically beneficial to FAs.

Objectives: To evaluate whether topical rapamycin-calcitriol combination is an effective and safe treatment for TSC-related FAs. Read More

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October 2020

Scleromyxedema histopathologically mimicking hypercellular fibrous papules (angiofibomas): Case report of an unusual histopathological presentation.

J Cutan Pathol 2020 Jul 20;47(7):638-642. Epub 2020 Feb 20.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York.

Scleromyxedema (SMX) is an inflammatory condition of unknown etiology strongly associated with monoclonal gammopathy. Classical histopathology of SMX is characterized with the triad of diffuse mucin deposits, increased amount of collagen, and presence of stellate fibroblasts. Herein, we report an unusual histopathological variant of SMX in a 41-year-old female with lesions of the nose histopathologically mimicking cellular angiofibromas. Read More

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[Primary juvenile nasal angiofibroma in a 38 year-old male (case report)].

Vestn Otorinolaringol 2019 ;84(5):76-80

N.N. Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia, 125047.

Juvenile nasal angiofibroma (JNA) is a benign, fibro-vascular, locally aggressive tumor with invasive growth patterns and high probability of recurrence. JNA present exclusively in adolescent boys between 9 and 19 years of age, total about 0.05% of head and neck tumors. Read More

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January 2020

Obstructive Sleep Apnea as the First Presentation of Juvenile Nasal Angiofibroma.

J Clin Sleep Med 2019 09;15(9):1373-1375

Pediatric Sleep Medicine at Saint Barnabas Medical Center, West Orange, New Jersey.

Citation: Lobl M, Zandieh SO. Obstructive sleep apnea as the first presentation of juvenile nasal angiofibroma. J Clin Sleep Med. Read More

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September 2019

Clinical and histopathological presentation and successful treatment with ciclosporin for canine sarcoidosis: a case report.

Vet Dermatol 2019 Oct 22;30(5):438-e136. Epub 2019 Jul 22.

Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, 252-5201, Japan.

Background: Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis is a rare disease which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face and ear; it is usually treated with corticosteroids. To date, there are no published reports on alternatives to corticosteroids treatment. Read More

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October 2019

Extranasopharyngeal Angiofibroma of the Frontal Sinus.

J Craniofac Surg 2019 Jul;30(5):e432-e433

Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea.

Angiofibroma is a rare tumor that accounts for about 0.05% of all head and neck tumors; it mainly occurs in the region of the nasopharynx. To date, no study originating in the frontal sinus has been reported. Read More

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Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a Single-Center, Open-Label Trial.

Child Neurol Open 2019 14;6:2329048X19835047. Epub 2019 Apr 14.

Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Facial angiofibromas, composed of fibrous tissue and blood vessels appearing on the face, are closely associated with tuberous sclerosis complex. Historically, oral rapamycin, a mammalian target of the rapamycin inhibitor of cell proliferation, has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine generally precludes its use in patients lacking significant internal involvement. The authors developed a novel topical formulation of rapamycin cream to treat the facial angiofibroma without exposing patients to possible systemic side effects. Read More

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Angiofibroma of the Eyelid: A Rare Clinical and Histologic Variant.

Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e199-e102

Departments of Ophthalmology.

A flesh-colored, supraciliary lesion of the left upper eyelid in a 47-year-old man was excised for cosmetic reasons. Histopathology and immunohistochemistry demonstrated CD34-positive benign spindle cells, factor XIIIa-positive dendritic cells, and CD163-positive histiocytes, all dispersed within a diffuse collagenous background. Prominent loose perivascular cuffs of fibroblastic cells and collagen surrounded small blood vessels. Read More

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December 2019

Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions.

J Craniofac Surg 2019 May/Jun;30(3):800-802

Department of Otolaryngology - Head and Neck Surgery.

Lesions involving the masseteric and buccal spaces have traditionally required transoral or transcervical approaches. Herein, the authors describe the successful endonasal endoscopic resection of a juvenile nasopharyngeal angiofibroma (JNA) with significant extension into the masseteric and buccal spaces facilitated by transoral finger retraction. Juvenile nasopharyngeal angiofibromas are hypervascular tumors originating in the pterygopalatine fossa (PPF) with complex relationships to skull base and orbital structures. Read More

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Management of persistent juvenile angiofibroma after endoscopic resection: Analysis of a single institution series of 74 patients.

Head Neck 2019 05 10;41(5):1297-1303. Epub 2018 Dec 10.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Background: Management of persistent juvenile angiofibroma (pJA) after transnasal endoscopic resection is controversial. To better understand its behavior, optimize treatment, and minimize morbidity, we report our experience in pJA focusing on follow-up strategies and disease progression.

Methods: A retrospective review of clinical records of all JA cases treated with endoscopic surgery at the Unit of Otorhinolaryngology of the University of Brescia between January 1994 and October 2015 was performed. Read More

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Intraoral Endoscopic Ligation of Maxillary Artery in the Infratemporal Fossa.

J Craniofac Surg 2019 Jan;30(1):137-140

Department of Otolaryngology - Head and Neck Surgery, Endoscopic Sinus Surgery and Skull Base Surgery, Autonomous University of Veracruz, Xalapa, Mexico.

Ligation of the sphenopalatine and posterior nasal arteries is indicated for posterior epistaxis as initial treatment or when conservative measures fail. In some patients, a transnasal approach or its alternative transantral approach are not possible due to tumor filling the nasal corridor, pterygopalatine fossa, or maxillary sinus. Aim of this study was to evaluate feasibility of endoscopically assisted transoral approach for the ligation of the maxillary artery (MA). Read More

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January 2019

Long-term neurological morbidity following endoscopic transnasal resection of juvenile angiofibroma.

Laryngoscope 2019 09 12;129(9):2184-2188. Epub 2018 Oct 12.

Unit of Otorhinolaryngology-Head and Neck Surgery.

Objectives/hypothesis: Although transnasal endoscopic resection (TER) of juvenile angiofibroma (JA) is unquestionably less invasive than traditional external approaches, several endonasal and neurovascular structures are sacrificed during the procedure. The aim of this study was to evaluate long-term neurological morbidity and related quality of life following TER of JA.

Study Design: Retrospective cohort study. Read More

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September 2019

The cutaneous manifestations of tuberous sclerosis complex.

Am J Med Genet C Semin Med Genet 2018 09 23;178(3):321-325. Epub 2018 Sep 23.

Department of Dermatology, UTHealth McGovern Medical School, Houston, Texas.

Tuberous sclerosis complex (TSC) is a genetic multisystem disease with variable manifestations that can prominently involve the skin. The diagnosis of this disorder has evolved over the past two centuries. The 2012 TSC criteria emphasizes the importance of dermatological findings; orocutaneous manifestations account for 4 of 11 major criterion and 3 of 6 minor criterion. Read More

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September 2018

Facial angiofibromas treated by rapamycin 0.05% ointment and a combined laser therapy.

J Cosmet Dermatol 2018 Oct 19;17(5):762-765. Epub 2018 Aug 19.

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

Background: Tuberous sclerosis is an autosomal dominant genodermatosis characterized by nonmalignant hamartomas in multiple organs. Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement. Facial disfigurement negatively affects the quality of life of patients and their families, often leading to negative psychosocial outcomes. Read More

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October 2018

Pediatric Nasal Obstruction.

Otolaryngol Clin North Am 2018 Oct 19;51(5):971-985. Epub 2018 Jul 19.

Department of Otolaryngology, Upper Airway Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2018, Cincinnati, OH 45229, USA; Department of Pulmonary Medicine, Upper Airway Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2018, Cincinnati, OH 45229, USA. Electronic address:

Nasal obstruction is one of the most common problems seen by pediatric otolaryngologists. Prompt treatment of nasal obstruction can be critical in newborns and infants because of their obligatory nasal breathing. Older children will typically have more inflammatory, infectious, or traumatic causes of nasal obstruction. Read More

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October 2018

Fibrous Papule: A Histopathologic Review.

Am J Dermatopathol 2018 Aug;40(8):551-560

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Fibrous papule (FP) is a common benign lesion located primarily in the nose. Although its histogenesis has been marred with controversies in the past, the dermal dendrocyte is now largely accepted to be the putative cell of origin. Histopathologic diagnosis of an FP is straightforward in most cases, which shows characteristics of an angiofibroma. Read More

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Calvian Endo-pen: New Coagulation Forceps for Endoscopic Endonasal Transsphenoidal Surgery.

J Neurol Surg A Cent Eur Neurosurg 2018 Nov 6;79(6):524-527. Epub 2018 Jul 6.

Department of ENT, HELIOS Klinikum Erfurt, Erfurt, Thüringen, Germany.

Objective:  Over the past few years bipolar electrocoagulation techniques in neurosurgery have been continually improving. However, limited access during endoscopic endonasal transsphenoidal surgery (EETS) for central skull base pathologies and the requirement of very precise coagulation in that dedicated anatomical area requires further refinement of bipolar coagulation instruments. We describe our experience (effectiveness of coagulation, intraoperative handling, and the use as a dissecting tool) with a new type of coagulation forceps, the Calvian endo-pen (Sutter Medizintechnik, Freiburg, Germany) during EETS. Read More

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November 2018

Cutaneous Manifestations of Tuberous Sclerosis.

Acta Dermatovenerol Croat 2018 Apr;26(1):73-74

Vladimir Prelević, MD, Clinic for Nephrology Clinical Center of Montenegro, Ljubljanska bb 81101 Podgorica, Montenegro;

Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). Read More

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Bilateral Giant Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Complex: A Case Report.

Acta Med Indones 2018 Jan;50(1):61-65

Department of Surgery, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.

Tuberous sclerosis complex (TSC) has several renal manifestations including angiomyolipomas (AML) and renal epithelial neoplasms. A bilateral giant renal AML is extremely rare. We report a case of giant bilateral AML and discuss the diagnosis and treatment of it. Read More

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January 2018

Masses of the Nose, Nasal Cavity, and Nasopharynx in Children.

Radiographics 2017 Oct;37(6):1704-1730

From the Department of Radiology, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205 (D.P.R.); and Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio (E.S.O., B.L.K.).

A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. Read More

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October 2017

Tuberous Sclerosis Complex in 29 Children: Clinical and Genetic Analysis and Facial Angiofibroma Responses to Topical Sirolimus.

Pediatr Dermatol 2017 Sep 2;34(5):572-577. Epub 2017 Aug 2.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background/objectives: Tuberous sclerosis complex (TSC) is a genetic disorder and facial angiofibromas are disfiguring facial lesions. The aim of this study was to analyze the clinical and genetic features of TSC and to assess the treatment of facial angiofibromas using topical sirolimus in Chinese children.

Methods: Information was collected on 29 patients with TSC. Read More

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September 2017

Nasopharyngeal angiofibroma in an adult with Proteus syndrome. First reported case.

Hippokratia 2017 Jul-Sep;21(3):147-149

2 Otolaryngology Department, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece.

Background: Proteus Syndrome (PS) is a rare hamartoneoplastic disorder consisting of a disproportionate and asymmetric overgrowth of body parts, leading to severe body and face disfigurement. Individuals with PS frequently need to undergo a number of surgical procedures including Otolaryngology interventions. Their peculiar anatomy turns even the most straightforward intervention to a challenging one. Read More

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November 2018

Tuberous Sclerosis Complex.

N Engl J Med 2017 May;376(20):e42

Universita degli Studi di Pisa, Pisa, Italy

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Reflectance confocal microscopy features of facial angiofibromas.

Dermatol Pract Concept 2017 Jan 31;7(1):51-54. Epub 2017 Jan 31.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.

Facial angiofibromas are benign tumors presenting as firm, dome-shaped, flesh-colored to pink papules, typically on the nose and adjoining central face. Clinically and dermoscopically they can mimic melanocytic nevi or basal cell carcinomas (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that is useful in diagnosing melanocytic and non-melanocytic facial lesions. Read More

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January 2017