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Int J Surg Case Rep 2021 May 29;84:106049. Epub 2021 May 29.

Department of Oral and Maxillofacial Surgery, Central University of Ecuador, Quito, Ecuador.

Introduction And Importance: Fibrous Dysplasia (FD) is a benign fibro-osseous lesion, characterized by replacement with fibrous connective tissue instead of normal bone. The best treatment option for the condition has not yet been established, although several therapeutic approaches have been reported. The present case report describes the clinical, imaging and therapeutic aspects of an atypical bilateral presentation of FD in the mandible. Read More

J Orthod 2021 Jun 8:14653125211021871. Epub 2021 Jun 8.

Department of Paediatric Dentistry, Glasgow Dental Hospital, Glasgow, UK.

Study models are frequently used in orthodontics and are a key part of both initial assessment and treatment planning. They are an important part of comprehensive orthodontic records; furthermore, study models are an essential diagnostic aid that can be studied in detail without the patient being present. We present a case of a 14-year-old boy with an abnormal palatal swelling detected by his specialist orthodontist after review of study models taken at the initial appointment. Read More

Diagnostics (Basel) 2021 May 31;11(6). Epub 2021 May 31.

Department of Radiology, Nuclear Medicine Division, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.

This paper details the case report of a 26-year-old man who presented with a growing right-sided skull mass evaluated with ultrasound, non-contrast CT, contrast-enhanced MRI and Tc-MDP whole body bone scan with SPECT/CT. These studies suggested a broad differential diagnosis favoring benign osseous lesions. Given a more recent increase in the rate of growth, headache and large size, the lesion was excised via craniotomy followed by cranioplasty. Read More

BMC Musculoskelet Disord 2021 May 19;22(1):460. Epub 2021 May 19.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.

Background: The calcar femorale was identified long ago. However, our current understanding of the calcar is insufficient, and its related concepts are sometimes confused. The calcar femoral is an important anatomical structure of the proximal femur, and its function can be overlooked. Read More

J Craniofac Surg 2021 Apr 29. Epub 2021 Apr 29.

Department of Maxillofacial Radiology, Faculty of Dentistry, Yeni Yuzyil University, Istanbul Department of Orthopedics and Traumatology, Van Training and Research Hospital, Van Department of Orthopedics and Traumatology, Tepecik Training and Research Hospital Department of Maxillofacial Radiology, Faculty of Dentistry, Ege University, Izmir, Turkey.

Abstract: Fibrous dysplasia (FD), a benign fibro-osseous bone tumor commonly involving the craniofacial region, presents a wide spectrum of radiographic patterns. When FD lesions are suspected, various imaging modalities and histopathologic analyses may be required to reach a firm diagnosis. Here, the authors report the case of a 10-year-old male patient presenting with polyostotic type of FD with follow-up data for the next 9 years. Read More

J Maxillofac Oral Surg 2021 Jun 8;20(2):240-245. Epub 2019 Nov 8.

Department of Oral and Maxillofacial Surgery, Sri Guru Ram Das Institute of Dental Sciences and Research, Mall Mandi, GT Road, Amritsar, 143001 India.

Introduction: Cemento-ossifying fibroma is considered as a benign osseous tumour, closely related to other lesions such as fibrous dysplasia and cementifying periapical dysplasia. These lesions occur in the second to the fourth decade of life. It is a bony tumour of maxilla and mandible of possibly odontogenic origin with aggressive behaviour and high tendency for recurrence. Read More

Bone Rep 2021 Jun 9;14:101058. Epub 2021 Apr 9.

Department of Internal Medicine, Division of Endocrinology, Center for Bone Quality, LUMC, Albinusdreef 2, 2333ZA Leiden, the Netherlands.

We present two patients with fibrous dysplasia who showed a decrease in lesional size and activity after denosumab therapy. Both patients also experienced a reduction in pain and bone turnover markers, which had not been accomplished during previous bisphosphonate therapy. These cases highlight the potential of denosumab to decrease lesional size in fibrous dysplasia. Read More

Int J Spine Surg 2021 Feb 29;14(s4):S46-S51. Epub 2020 Dec 29.

Department of Orthopaedics and Traumatology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

Fibrous dysplasia of the spine in a polyostotic form is very rare, with fewer than 36 cases discussed in the literature and there is no such case in Indonesia that has been reported. The aim of this report is to present a case from Indonesia of polyostotic fibrous dysplasia isolated in the spine. We report a case of a 38-year-old Sundanese man with a 1-year history of progressive back pain and weakness of both lower extremities. Read More

Clin Nucl Med 2021 Apr 20. Epub 2021 Apr 20.

From the Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; and Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.

Abstract: 68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) PET imaging has been introduced for detecting many primary and metastatic tumors. However, false-positive uptakes have been reported in some benign lesions. Here, we presented a 68Ga-FAPI-avid lesion in the left temporal bone in a 41-year-old man with a history of signet ring cell gastric adenocarcinoma. Read More

Acta Orthop Traumatol Turc 2021 Mar;55(2):184-188

Department of Orthopaedics and Traumatology, Hacettepe University, School of Medicine, Ankara, Turkey.

Focal fibrocartilaginous dysplasia (FFCD) is a rare disease that can cause angular deformities of long bones. The common pathologic finding is a thick fibrotic band extending from epiphysis to metaphysis on one side of the bone. The tethering effect of the fibrotic band around the growth plate is thought to be the main etiology for the development and progression of the deformity. Read More

Semin Ultrasound CT MR 2021 Apr 29;42(2):150-163. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

We will provide an imaging-focused discussion of 3 benign bone tumors that do not fit in the categories of cartilaginous tumors or osteoid tumors. We have chosen giant cell tumor of bone, unicameral bone cyst, and fibrous dysplasia. All 3 of these entities are common enough that one does not have to be a musculoskeletal radiologist in a cancer hospital to encounter them occasionally, but none of them should be seen frequently. Read More

Int J Surg Pathol 2021 Apr 1:1066896921997141. Epub 2021 Apr 1.

195112Mayo Clinic, Rochester, MN, USA.

. Fibrous dysplasia (FD) is a benign fibro-osseous neoplasm that most commonly arises in the ribs, femur, and craniofacial bones. We analyzed features of FD arising in the spine/short tubular/small bones of the hands/feet (STSBHF), specifically assessing for pattern of bone formation (conventional, complex/anastomosing, psammomatoid/cementum like), myxoid change, and presence of osteoclast-type giant cells. Read More

J Clin Endocrinol Metab 2021 Mar 31. Epub 2021 Mar 31.

Center for Bone Quality, dept. of Internal Medicine, division of Endocrinology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.

Context: The correlation between Fibrous Dysplasia/McCune-Albright syndrome (FD/MAS) skeletal disease burden on Na[18F]F-PET-CT and serum bone turnover markers (BTMs) was recently described. The effect of treatment on lesional fluoride burden in FD/MAS is unknown.

Objective: To investigate treatment response measurements in FD/MAS patients who underwent Na[18F]F-PET-CT and treatment with antiresorptives. Read More

Neurosurg Rev 2021 Mar 22. Epub 2021 Mar 22.

Department of Neurosurgery, Eberhard Karls University Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

Calvarial lesions are rare and can present as a variety of different diseases. The lesions can be palpable on the skin and cause local pain and paraesthesia and, depending on the location, neurological deficits can also occur. This research aims to present an overview of typical imaging features as well as neurosurgical management. Read More

J Craniofac Surg 2021 Mar 17. Epub 2021 Mar 17.

Department of Plastic and Reconstructive Surgery, Saitama Medical Center, Jichi Medical University Department of Plastic and Reconstructive Surgery, Jichi Medical University Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Tochigi 329-0498, Japan.

Abstract: The authors report a case of a rare, large, nodular pseudogout which developed from the temporomandibular joint (TMJ).An 83-year-old female was referred to the hospital with swelling on her left cheek. Imaging studies revealed a large calcified mass surrounding the left mandibular condyle, partially destroying the adjoining bone and extending to the skull base. Read More

Acta Biomed 2020 10 13;92(1):e2021018. Epub 2020 Oct 13.

Department of Neurosciences, Section of Otolaryngology and Regional Centre for Head and Neck Cancer, University of Padova, Treviso, Italy; Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Padova, Italy.

Background And Aim Of The Work: Fibrous dysplasia is a fibro-osseous osteopathy in which the normal bone architecture is replaced by fibrous tissue and non-functional trabeculae-like osseous structures. In head and neck area monostotic or polyostotic lesions cause a progressively expanding destructive bone swelling producing cosmetic deformities and functional impairments. The aim of this article is to present a retrospective review of a clinical case series with pathologically confirmed jawbone fibrous dysplasia for over an 8-year-period. Read More

Neuroradiol J 2021 Mar 8:1971400921998967. Epub 2021 Mar 8.

Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Egypt.

Bone-related disorders of the jaw (BRDJ) include a spectrum of non-neoplastic and neoplastic lesions of the maxillofacial region that have been recently classified into fibro-osseous lesions, giant cell lesions and osseous tumours. The histopathological features of BRDJ can be similar and overlie each other. Imaging is important in order to reach a specific diagnosis. Read More

World J Clin Cases 2021 Feb;9(5):1111-1118

MRI Department, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China.

Background: Fibrous dysplasia (FD) is a common benign intramedullary fibro-osseous lesion. Involvement of the spine is rare, with the literature including only case reports, and cases of monostotic FD (MFD) in the sacrum are extremely rare. A correct preoperative diagnosis of spinal MFD is important for clinicians to select proper treatment. Read More

Ann Nucl Med 2021 Mar 13;35(3):397-405. Epub 2021 Feb 13.

Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine Kyoto University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Objective: Tumor-induced osteomalacia (TIO) is caused by typically small tumors that secrete fibroblast growth factor 23 (FGF23). As tumor resection is the only effective treatment for TIO, it is important to detect the culprit tumor. We aimed to assess the utility of Gallium-DOTA-D-Phe(1)-Tyr(3)-octreotide (Ga-DOTATOC) PET/CT in TIO and the correlation between biochemical parameters and the PET/CT results. Read More

Int J Clin Exp Pathol 2021 1;14(2):247-251. Epub 2021 Feb 1.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, Hubei, China.

Fibrous dysplasia of bone (FDB) is a rare bone disease that may be misdiagnosed as bone metastasis in terms of some symptoms and imaging features. Therefore, the differential diagnosis between FDB and bone metastasis may be a challenge. To our knowledge, there are no reports in the literature to date regarding concomitant nasopharyngeal carcinoma (NPC) with FDB. Read More

Aust Endod J 2021 Apr 1;47(1):105-112. Epub 2021 Feb 1.

Department of Oral and Maxillofacial Radiology, School of Dentistry, Aichi Gakuin University, Aichi, Japan.

Cemento-osseous dysplasia (COD) is a lesion in which periapical bone is replaced by fibrous tissue, including osseous or cementum-like tissue. In the initial stage of COD, radiolucencies are noted at the root apex on periapical radiography, which can be confused with apical periodontitis. Understanding of correct pathological condition and careful assessment of COD is critical to avoid unnecessary endodontic interventions in healthy teeth. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Apr 29;131(4):385-389. Epub 2021 Jan 29.

Professor and Chair, Oral & Maxillofacial Radiology, Department of Oral, Biological and Medical Sciences, The University of British Columbia, Vancouver, BC, Canada.

Endocr Pract 2020 Aug;26(8):931

From the Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Electronic address:

Arq Bras Oftalmol 2020 Nov-Dec;83(6):535-537

Division of Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

A 65-year-old female patient was referred to our hospital for evaluation for cataract surgery. Her past medical history included corrective jaw surgeries for facial deformities that developed during infancy and persisted through early adulthood. A complete ophthalmological examination revealed bilateral angioid streaks, drusen in both optic disc areas, and a subretinal neovascular membrane in the left macula. Read More

JBJS Case Connect 2020 10 16;10(4):e20.00157. Epub 2020 Oct 16.

Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Japan.

Case: We report the case of a 78-year-old woman with undifferentiated pleomorphic sarcoma (UPS) of the proximal femur arising in a previous site of fibrous dysplasia (i.e., a liposclerosing myxofibrous tumor) that had been treated 4 years earlier with curetted surgery. Read More

Clin Nucl Med 2021 Jul;46(7):e349-e352

From the Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai.

Abstract: A 43-year-old man diagnosed with fibrous dysplasia with McCune-Albright syndrome was subjected to 18F-fluoride bone scan and 68Ga-PSMA-HBED-CC PET/CT as per the institution protocol. 18F-bone scan revealed extensive involvement of axial and appendicular skeleton confirming polyostotic fibrous dysplasia. 68Ga-PSMA PET/CT showed increased tracer uptake in corresponding lesions of fibrous dysplasia. Read More

Vet Surg 2021 Feb 5;50(2):383-392. Epub 2021 Jan 5.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, USA.

Objective: To describe the presentation, diagnosis, treatment, and outcome for horses with fibro-osseous lesions of the craniofacial complex.

Study Design: Retrospective multicenter case series.

Animals: Thirty horses evaluated for fibro-osseous lesions of the skull from January 1, 2001 through December 31, 2019 in four centers. Read More

J Oral Maxillofac Surg 2021 May 26;79(5):1053-1061. Epub 2020 Nov 26.

Professor, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Purpose: Differential diagnosis of chronic diffuse sclerosing osteomyelitis of the mandible (DSOM) and craniofacial fibrous dysplasia (CFD) involving the mandible is challenging. The purpose of this study was to explore the differences of the clinical and radiographic characteristics between these 2 conditions.

Patients And Methods: In this retrospective cross-sectional, blinded, comparative study, clinical and imaging data of patients with DSOM and CFD at the Peking University Hospital of Stomatology from 2012 to 2018 were retrieved. Read More

Radiol Case Rep 2021 Feb 28;16(2):230-236. Epub 2020 Nov 28.

Radiology Department, Watford General Hospital, Vicarage Road, Watford WD18 0HB, United Kingdom.

Fibrous dysplasia is a benign, congenital skeletal disorder which leads to the formation of fibro-osseous intramedullary bone lesions. Clival fibrous dysplasia is a rare variant which commonly presents asymptomatically with no findings on examination and is often picked up incidentally on radiological investigation. A 39-year-old female presented with a sudden onset headache of 3 days' duration alongside diplopia and right lower limb weakness upon examination. Read More

Curr Med Imaging 2020 Dec 8. Epub 2020 Dec 8.

Ankara University, Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara. Turkey.

Background: McCune-Albright Syndrome (MAS) is a genetic disorder with a triad of endocrine diseases, caféau-lait macules and fibrous dysplasias. Craniofacial fibrous dysplasia is a term that is used to describe the fibrous dysplasia which were localized at the craniofacial skeleton and it is common in MAS patients.

Objective: The objective of this review is to determine the involvement frequency of cranial and facial bones in the patients with MAS and CFD. Read More