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Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More

Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.

Acute Geriatrics Unit, Monza (MB). Italy.

Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

Transpl Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

Background: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown.

Methods: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28). Read More

IEEE Trans Nanobioscience 2018 Nov 30. Epub 2018 Nov 30.

In this study, we separately fabricated the poly (ε-caprolactone) (PCL) scaffolds containing epidermal growth factor (EGF) by using our-self fabricated electrospinning machine for tissue regeneration application. Several fundamental properties, including the dimensions, wettability and EGF release profiles, of the fabricated EGF-PCL the bead, fibrous and multistructured scaffolds were characterised by using the Scanning Electron Microscopy (SEM), contact angle goniometer and vertical diffusion system. The EGF release profiles of three scaffolds were measured for 200 hours and the multistructured scaffold performed stable and long EGF release properties. Read More

J Mater Sci Mater Med 2018 Nov 30;29(12):182. Epub 2018 Nov 30.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.

3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. Read More

J Tissue Eng 2018 Jan-Dec;9:2041731418808633. Epub 2018 Nov 14.

Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Soft tissue generation, especially in large tissue, is a major challenge in reconstructive surgery to treat congenital deformities, posttraumatic repair, and cancer rehabilitation. The concern is along with the donor site morbidity, donor tissue shortage, and flap necrosis. Here, we report a dissection-free adipose tissue chamber-based novel guided adipose tissue regeneration strategy in a bioreactor of elastic gelatin cryogel and polydopamine-assisted platelet immobilization intended to improve angiogenesis and generate large adipose tissue in situ. Read More

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Hemangiopericytomas (HPCs) are rare vascular tumors that resemble meningiomas on imaging and have a high rate of local recurrence and metastases. There remains a paucity of data to guide management decisions of intraspinal dissemination of HPC in the literature, and none specifically related to anaplastic HPCs.

Case Description: Case report of a 34-year-old female with locally and distantly recurrent anaplastic hemangiopericytoma (HPC) (WHO grade III). Read More

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Zoological Institute, Russian Academy of Sciences, Saint-Petersburg, Russia.

Silk spinning is widely-spread in trombidiform mites, yet scarse information is available on the morphology of their silk glands. Thus this study describes the fine structure of the prosomal silk glands in a small parasitic mite, Ornithocheyletia sp. (Cheyletidae). Read More

BMC Pediatr 2018 Dec 4;18(1):382. Epub 2018 Dec 4.

Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Nanlishi Road 56, Xicheng District, Beijing, People's Republic of China.

Background: Mediastinal teratoma is uncommon in children. It can be very difficult to diagnose especially in early stage. Rarely, teratoma may rupture into adjacent structures and lead to lung lesions or pleuritis. Read More

Rev Prat 2017 Jun;67(6):628-631

Service d'urologieandrologie, CHU Carémeau, Nîmes, France.

Lapeyronie's disease. Lapeyronie's disease is a common condition responsible for an acquired penile curvature due to a fibrous albugineal plaque, affecting 3.4 to 9% of the male population. Read More

Int J Surg Case Rep 2018 Nov 27;54:10-14. Epub 2018 Nov 27.

Deptt. of Pathology, PGIMS Rohtak, Haryana, India. Electronic address:

Introduction: Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin that occurs most often in the visceral pleura. It rarely occurs in the central nervous system (CNS). If they occur intracranially, they are extra-axially located and develop from the meninges. Read More

Colloids Surf B Biointerfaces 2018 Nov 8;175:26-35. Epub 2018 Nov 8.

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

Biocompatible and highly porous network hydrogel scaffolds were fabricated for the development of artificial cornea (AC) periphery/skirt that could be used to enhance the long-term retention of the implants. In this study, a series of hydrogel scaffolds for this application was fabricated from the photo-polymerization of a mixture of poly(ethylene glycol) (PEG)- and poloxamer (P407)-based macromer solutions in dichloromethane in which solvent-induced phase separation (SIPS) arose to form scaffolds with macroporous structure and high water content. The overall porosity ranging from 20% to 75% and open/closed pore structure of the hydrogel scaffolds could be finely tuned by varying the ratio of P407/PEG in the macromer solution and solvent type. Read More

Radiol Oncol 2018 Nov 26;52(4):353-364. Epub 2018 Nov 26.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.

Background Liver cancer is the sixth most common cancer worldwide and the second leading cause of cancer mortality. Chronic liver disease caused by viral infection, alcohol abuse, or other factors can lead to cirrhosis. Cirrhosis is the most important clinical risk factor for hepatocellular carcinoma (HCC) whereby the normal hepatic architecture is replaced by fibrous septa and a spectrum of nodules ranging from benign regenerative nodules to HCC, each one of them with different imaging features. Read More

Chem Commun (Camb) 2018 Dec 4. Epub 2018 Dec 4.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.

Reversible imine exchange is adopted to molecularly re-arrange polyazomethine-based amorphous fibers into covalent organic frameworks (COFs) retaining pristine fibrous characters with periodic and oriented micropore channels. Such fibrous COFs can immobilize the assembled Nafion to form long-range proton conduction pathways, thus largely promoting proton transport. Read More

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Fibrous sheath interacting protein 1 (FSIP1) is a cancer antigen expressed in the majority of breast cancer tissues and is associated with poor prognosis. However, the role of FSIP1 in the progression and drug sensitivity of triple-negative breast cancer (TNBC) has not been explored. Here, we show that FSIP1 deficiency by shRNA-mediated knockdown or CRISPR-Cas9-mediated knockout significantly inhibits the proliferation and invasion of TNBC cells and impairs chemotherapy-induced growth inhibition in vivo. Read More

Biomed Eng Online 2018 Dec 3;17(1):179. Epub 2018 Dec 3.

Department of Medical Physics, School of Foundational Education, Peking University Health Science Center, Beijing, 100191, China.

Background: The purpose of this study is to explore the potential of phase contrast imaging to detect fibrotic progress in its early stage; to investigate the feasibility of texture features for quantified diagnosis of liver fibrosis; and to evaluate the performance of back propagation (BP) neural net classifier for characterization and classification of liver fibrosis.

Methods: Fibrous mouse liver samples were imaged by X-ray phase contrast imaging, nine texture measures based on gray-level co-occurrence matrix were calculated and the feasibility of texture features in the characterization and discrimination of liver fibrosis at early stages was investigated. Furthermore, 36 or 18 features were applied to the input of BP classifier; the classification performance was evaluated using receiver operating characteristic curve. Read More

Bioresour Technol 2018 Nov 26;274:180-189. Epub 2018 Nov 26.

LBE, INRA, Univ Montpellier, 102 avenue des Etangs, 11100 Narbonne, France.

Digestate mechanical separation is present in numerous anaerobic digestion plants. In this study, data from literature and from unpublished analysis were gathered to evaluate digestate separation efficiency for different mechanical separators. For the first time, efficiency indicators allowed the definition of two mass distribution profiles. Read More

Opt Lett 2018 Dec;43(23):5865-5868

We demonstrate for the first time, to the best of our knowledge, Raman random lasing in a continuous-wave (CW) excited, completely biocompatible and biodegradable carrot medium naturally composed of fibrous cellulose scattering medium and rich carotene Raman gain medium. The CW-laser-induced photoluminescence threshold and linewidth analysis at the Stokes modes of carotene show a characteristic lasing action with a threshold of 130  W/cm and linewidth narrowing with mode Q factor up to 1300. Polarization study of output modes reveals that lasing mode mostly retains the source polarization state. Read More

Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.

Solitary fibrous tumor/hemangiopericytoma seldom arises from the optic nerve sheath. Herein, we describe the clinical, radiological, and histological findings of a solitary fibrous tumor/hemangiopericytoma arising from the optic nerve sheath and occupying the optic canal. The diagnosis is challenging both clinically and histologically as it clinically simulates a commoner lesion, i. Read More

Vestn Oftalmol 2018 ;134(5):4-14

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021; I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.

The article describes a newly developed and tested diffractive optical element (DOE) that converts non-uniform radiation of the laser output into a homogeneous ring. The Gerchberg-Saxton algorithm is shown to be well suited for achieving annular intensity distribution. Testing this ring transducer on threshold-plasticity cornea demonstrated the reversibility of axisymmetric changes in the cornea. Read More

Ann Transl Med 2018 Oct;6(20):407

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Background: This study aimed to evaluate the survival of the advanced non-small cell lung cancer (NSCLC) patients underwent salvage surgeries after EGFR-TKI neoadjuvant therapies.

Methods: From 2014 to 2016, 10 patients diagnosed as advanced stage NSCLC (N2 metastasis or great vessels invasion) who responded to EGFR-TKI neoadjuvant therapy were recruited in this study. All patients underwent surgeries and consented the follow-up study. Read More

Case Rep Orthop 2018 25;2018:1593021. Epub 2018 Oct 25.

Department of Orthopedic Surgery, Wakayama Medical University, Japan.

There is little evidence regarding the optimal approach to treatment for delayed-onset lumbar radiculopathy due to foraminal stenosis after osteoporotic vertebral fracture. Here, we describe the use of spinal endoscopy for the treatment of this disabling condition, in an 80-year-old woman presenting with severe radicular pain following an osteoporotic lumbar compression fracture. Radiographic findings showed the compression of the L2 root within the foramen, and computed tomography identified a fragment of the posterior wall of the vertebral body under the pedicle. Read More

Cesk Patol 2018 ;63(4):191-194

Hyalinizing trabecular tumor is a rare neoplasm usually with benign clinical behavior. Exceptionally it shows characteristic features of malignant tumors, such as the presence of venous or capsular invasion or distant metastasis. We report the case of 45-years-old female with a palpable nodule in the right lobe of the thyroid gland, 8x8x10 mm in size, well circumscribed, white colored. Read More

Lond Med Phys J 1817 Jun;37(220):466-471

J Bone Miner Res 2018 Nov 29. Epub 2018 Nov 29.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone. Local bone remodeling regulation by BMSCs is also altered, and FD tissue is characterized by abundant osteoclast-like cells that may be essential for lesion expansion. Read More

Mikrochim Acta 2018 Nov 28;185(12):561. Epub 2018 Nov 28.

Department of Chemistry, College of Science, Hebei Agricultural University, Baoding, 071001, Hebei, China.

A fibrous magnetic boron nitride nanocomposite was synthesized and is shown to be a viable adsorbent for the magnetic solid phase extraction of pesticides prior to their quantitation by gas chromatography with electron capture detection. The optimum conditions were obtained by both single factor optimization and response surface analysis (Box-Behnken design). Under the optimized conditions, the response to the ten pesticides (dicofol, α-endosulfan, p,p'-DDE, nitrofen, β-endosulfan, p,p'-DDD, p,p'-DDT, bifenthrin, permethrin and fenvalerate) is linear in the 0. Read More

Bull Exp Biol Med 2018 Dec 28;166(2):274-278. Epub 2018 Nov 28.

N. N. Priorov Central Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Moscow, Russia.

Structural dynamics of the fibrous basis of the reparative regenerate during spontaneous skin wound healing comprises multiple stages, it successively transforms from one organization level to another more complex level, forms a multilevel 3D structure including molecular, supramolecular, fibrillar, fiber, and tissue elements. The formed reparative regenerate is integrated with the preserved skin, together they have common fibrous basis consisting of three parts that are different in organization of fibrous structures: atypical (central), tissue organospecific (peripheral), and transitional. Read More

Nanoscale Res Lett 2018 Nov 29;13(1):384. Epub 2018 Nov 29.

College of Civil Engineering and Mechanics, Xiangtan University, Xiangtan, 411105, Hunan, China.

Polyurethane (PU) nanofibers were prepared from electrospun method. Atomic force microscopy (AFM) was employed to characterize the mechanical properties of electrospun PU nanofibers. The impact of temperature on the mechanical behavior of PU nanofibers was studied using three-point bending test based on AFM. Read More

Eur J Orthop Surg Traumatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Studies over the past decade have reported that the use of highly porous sockets in total hip arthroplasty (THA) results in osseointegration and long-term implant stability. However, some reports have raised concerns regarding radiographic evidence of poor osseointegration with features of fibrous tissue ingrowth. The purpose of this study was to compare clinical and radiographic assessments of highly porous sockets with those of hydroxyapatite (HA)-coated porous sockets in THA for hip dysplasia (DDH) at least 1 year after surgery. Read More

Circ J 2018 Nov 29. Epub 2018 Nov 29.

Division of Cardiology, Osaka Rosai Hospital.

Background: There are few reports about the differences between drug-eluting stents (DES) and bare metal stents (BMS) in neoatherosclerosis associated with in-stent restenosis (ISR), so we compared the frequency and characteristics of neoatherosclerosis with ISR evaluated by optical coherence tomography (OCT) in the present study. Methods and Results: Between March 2009 and November 2016, 98 consecutive patients with ISR who underwent diagnostic OCT were enrolled: 34 patients had a BMS, 34 had a 1st-generation DES, and 30 had a 2nd-generation DES. Neoatherosclerosis was defined as a lipid neointima (including a thin-cap fibroatheroma [TCFA] neointima, defined as a fibroatheroma with a fibrous cap <65 µm) or calcified neointima. Read More

Sci Transl Med 2018 Nov;10(469)

Comprehensive Pneumology Center, Institute of Lung Biology and Disease,Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

Peritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and are a major cause of postsurgical and infectious morbidity. The primary molecular chain of events leading to the initiation of adhesions has been elusive, chiefly due to the lack of an identifiable cell of origin. Using clonal analysis and lineage tracing, we have identified injured surface mesothelium expressing podoplanin (PDPN) and mesothelin (MSLN) as a primary instigator of peritoneal adhesions after surgery in mice. Read More

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4027-4032

Institute of Material Medical Planting, Chongqing Engineering Research Center for Fine Variety Breeding Techniques of Chinese Materia Medica, Chongqing Academy of Chinese Materia Medica, Chongqing Key Laboratory of Chinese Medicine Resources, Chongqing Sub-center of National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Science, Chongqing 400065, China.

With Coptis chinensis in high-yielding soil as the object,the growth regularity of plant and dynamic change of alkaloid content was studied. The plant growth model of C. chinensis was constructed. Read More

J Neurosurg 2018 Oct 1:1-8. Epub 2018 Oct 1.

OBJECTIVEThe relationship between intraplaque hypoxia and intraplaque hemorrhage (IPH) has been reported, but the details remain obscure. In this study, the authors aimed to clarify the relationship among intraplaque hypoxia, endothelial progenitor cells (EPCs), and neovascularization, which causes IPH. The histological findings of specimens obtained from carotid endarterectomy were assessed. Read More

Insights Imaging 2018 Nov 27. Epub 2018 Nov 27.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive Room 228 MSC 4320, Bethesda, MD, 20892, USA.

Fibrous dysplasia (FD) is a congenital disorder arising from sporadic mutation of the α-subunit of the Gs stimulatory protein. Osseous changes are characterised by the replacement and distortion of normal bone with poorly organised, structurally unsound, fibrous tissue. The disease process may be localised to a single or multiple bones. Read More

Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):445-448

Department of Stomatology, Central Hospital of Xuzhou City. Xuzhou 221009, Jiangsu Province, China.

McCune-Albright Syndrome(MAS) is a rare disease characterized by triad of polyostotic fibrous dysplasia of bone(FD), precocious puberty, and café-au-lait skin pigmentation. This paper reported a case of McCune-Albright syndrome with hyperthyroidism, and discussed the pathogenesis, clinical manifestations, diagnosis and treatment of MAS. Read More

Am J Otolaryngol 2018 Sep 18. Epub 2018 Sep 18.

Department of Otolaryngology - Head & Neck Surgery, Emory University, Medical Office Tower (MOT), 9th Floor, 550 Peachtree Street NE, Atlanta, GA 30308, United States of America. Electronic address:

We present a rare case of a vascular anomaly of the sphenoid and temporal bones causing an expandable mass of the temporal region with dependent patient positioning and characteristic osseous changes on imaging. Initial diagnosis considerations included multiple myeloma (MM), fibrous dysplasia (FD), Paget's disease, lymphoma, meningoencephalocele (MEC), and vascular malformation (VaM). VaMs of the head and neck are rare and typically arise in the mandible and maxilla. Read More

Int J Surg Pathol 2018 Nov 27:1066896918814304. Epub 2018 Nov 27.

1 Aichi Gakuin University, Nagoya, Japan.

Adenoid cystic carcinoma is one of the most common salivary gland malignancies with poor long-term prognosis, but the coexistence of sialoliths is extraordinarily rare. In this article, we report a case of 30-year-old woman with a history of submandibular area swelling with intermittent pain increasing during mealtimes that had led her attending physician to diagnose a sialolith in the left submandibular gland on a radiograph 10 years before. However, the surgical specimen proved to be an adenoid cystic carcinoma accompanied with a sialolith. Read More

Am J Rhinol Allergy 2018 Nov 28:1945892418815044. Epub 2018 Nov 28.

4 Department of Otolaryngology-Head & Neck Surgery, Albaha University, Al Bahah, Saudi Arabia.

Background: Although several studies have commented on causes of dacryocystorhinostomy (DCR) failure, detailed description of anatomical findings in such cases remains insufficient.

Objective: Our objective was primarily to analyze radiologic, endoscopic, and intraoperative findings in patients presenting with failed DCR and secondarily to assess the outcome of revision endoscopic DCR (endo-DCR) carried out at our institution.

Methods: Twenty-four failed DCRs presenting to our tertiary care center were retrospectively analyzed. Read More

PLoS One 2018 27;13(11):e0207943. Epub 2018 Nov 27.

Dept. of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background And Aims: With the intention to gain support for the hypothesis that incident ischemic complications of atherosclerotic disease involve a stochastic aspect, we performed a histological, qualitative evaluation of the epidemiology of coronary atherosclerotic disease in a cohort of aortic valve donors.

Patients And Methods: Donors (n = 695, median age 54, range 11-65 years) were dichotomized into a non-cardiovascular (non-CVD) and a cardiovascular disease death (CVD) group. Consecutive 5 mm proximal left coronary artery segments were Movat stained, and the atherosclerotic burden for each segment was graded (revised AHA-classification). Read More

PLoS One 2018 27;13(11):e0207581. Epub 2018 Nov 27.

Department of Musculoskeletal Tumors, Peking University People's Hospital, Beijing, People's Republic of China.

The surgical treatment of primary solitary fibrous tumors (SFT) involving the pelvic ring has not been reported previously. In this study, we aimed to evaluate the efficacy of surgical treatment for this disease. From 2009 to 2015, 13 patients underwent tumor resection at our hospital, with an average age of 49. Read More

Dermatol Pract Concept 2018 Oct 31;8(4):337-339. Epub 2018 Oct 31.

Department of Pathology, Hospital Universitario de Móstoles, Madrid, Spain.

Bone Res 2018 20;6:33. Epub 2018 Nov 20.

1Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA USA.

How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. Read More

Australas J Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Dermatology Department, Hospital General Universitario de Alicante, Alicante, Spain.

Background/objectives: The aim of this study was to evaluate the morphological findings of lipidised dermatofibromas under dermoscopic observation.

Methods: Dermoscopic examination of 13 cases of lipidised dermatofibromas was performed to evaluate specific dermoscopic criteria and patterns.

Results: The most frequently occurring dermoscopic features were as follows: (i) A yellowish homogenous pigmentation in all cases (100%); this pigmentation was total in 30. Read More

Eur Heart J 2018 Nov 26. Epub 2018 Nov 26.

Department of Cardiovascular Surgery, Shenzhen Sun Yat-sen Cardiovascular Hospital, No. 12 Langshan Road, Shenzhen, Guangdong Province, China.

Biomater Sci 2018 Nov 26. Epub 2018 Nov 26.

IRCSS Casa Sollievo della Sofferenza, Unità di Ingegneria Tissutale, Viale Cappuccini 1, San Giovanni Rotondo, FG 71013, Italy. and Center for Nanomedicine and Tissue Engineering (CNTE), ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore 3, Milan 20162, Italy.

Self-assembling peptides (SAPs) are synthetic bioinspired biomaterials that can be feasibly multi-functionalized for applications in surgery, drug delivery, optics and tissue engineering (TE). Despite their promising biocompatibility and biomimetic properties, they have never been considered real competitors of polymers and/or cross-linked extracellular matrix (ECM) natural proteins. Indeed, synthetic SAP-made hydrogels usually feature modest mechanical properties, limiting their potential applications, due to the transient non-covalent interactions involved in the self-assembling phenomenon. Read More

Eur J Orthop Surg Traumatol 2018 Nov 24. Epub 2018 Nov 24.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Orthopaedic Specialists - UPMC, 9104 Babcock Blvd, 5th Floor, Pittsburgh, PA, 15237, USA.

Purpose: We retrospectively reviewed the results of 89 patients with proximal pole scaphoid nonunion, 58 with avascular necrosis, treated with a capsular-based vascularized distal radius graft.

Methods: Seventy-one male and eighteen female patients with symptomatic nonunion at the proximal pole of the scaphoid were included in this study. No patient had a humpback deformity. Read More