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Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Unit of Nuclear Medicine, Aosta Regional Hospital, Aosta, Italy.

Prostate cancer is one of the most common malignancies. Imaging tools play an important role throughout the entire process of the disease. The scenario, however, is going to change. Read More

Int J Paleopathol 2019 Mar 23;25:1-8. Epub 2019 Mar 23.

Department of Cultural Heritage, University of Bologna, via degli Ariani 1, 48121, Ravenna, Italy; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany.

Objective: To evaluate, via a multidisciplinary approach, a distinctive paleopathological condition, believed to be fibrous dysplasia, found on a 19th/20th century skeleton from Certosa Monumental Cemetery, Bologna, Italy.

Materials: A skeletonized cranium and mandible recovered from an ossuary in 2014.

Methods: Pathological alterations were analysed by radiological examination, dental macrowear, histopathological and genetic analyses. Read More

Turk Neurosurg 2018 Nov 21. Epub 2018 Nov 21.

Tokat Gaziosmanpasa University Medicine School.

Aim: Fibrous dysplasia (FD) is relatively rare in craniofacial region compared to other regions of body. In the present study, radiological findings of FD detected in patients who had computed tomography (CT) and/or magnetic resonance imaging (MRI) were evaluated.

Material And Methods: This study included a total of 25 patients (17 female and 8 male) who were found to have FD based on CT examinations in March 2010-July 2018 period. Read More

Cleft Palate Craniofac J 2019 Feb 27:1055665619833294. Epub 2019 Feb 27.

1 Division of Plastic and Reconstructive Surgery, Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, IL, USA.

Juvenile psammomatoid ossifying fibroma (JPOF) is a rare benign osseous tumor, usually presenting in the midface. There are many similarities in location, presentation, and radiographic appearance between fibrous dysplasia (FD) and JPOF. Awareness of this entity is important for craniofacial surgeons, as surgical timing and intraoperative management differ between these tumors. Read More

Maxillofac Plast Reconstr Surg 2018 Dec 6;40(1):38. Epub 2018 Dec 6.

1Department of Oral and Maxillofacial Surgery, Dental Hospital, Kyung-hee University Hospital at Gang-dong, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278 Republic of Korea.

Background: Fibrous dysplasia (FD) is a benign bone lesion characterized by the progressive replacement of normal bone with fibro-osseous connective tissue. The maxilla is the most commonly affected area of facial bone, resulting in facial asymmetry and functional disorders. Surgery is an effective management option and involves removing the diseased bone via an intraoral approach: conservative bone shaving or radical excision and reconstruction. Read More

J Orthop Case Rep 2018 May-Jun;8(3):33-37

Department of Orthopaedics, Sri Ramachandra Medical University, Chennai, Tamil Nadu, India.

Introduction: Fibrous dysplasia is a rare benign disorder of the skeletal system characterized by fibro-osseous proliferation with intervening areas of normal or immature bone in the intramedullary region. It can either be a monostotic (involves one bone) or a polyostotic (involves more than one bone) presentation and usually occurs equally in males and females. Deformities such as scoliosis and shepherd's crook deformity are frequently encountered in the polyostotic form. Read More

Craniomaxillofac Trauma Reconstr 2018 Dec 16;11(4):314-319. Epub 2017 Nov 16.

Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, Faculty of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

Fibrous dysplasia is a benign fibroosseous disorder that can affect the maxillary bones, causing aesthetic deformity and functional impairment. This article reports the case of a 13-year-old male patient at the time of diagnosis. The patient showed increased facial volume with relevant asymmetry, having reported the onset of the condition 12 months before. Read More

BMC Med Imaging 2018 12 19;18(1):54. Epub 2018 Dec 19.

Institute of Pathology, School of Medicine, University of Belgrade, Dr Subotica 1, 11000, Belgrade, Republic of Serbia.

Background: This is the first reported case of a primary intraosseous angioleiomyoma and the second case of a primary leiomyoma of the rib, irrespective of age. Angioleiomyomas mostly occur in patients of advanced age, in any part of the body, particularly the lower extremities and present as painful, slow-growing nodules in the dermis, subcutaneous fat or deep fascia. Other localizations, especially bone, are considered extremely rare, as well as their occurrence in paediatric patients. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 4;136(2):119-121. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

Insights Imaging 2018 Dec 27;9(6):1035-1056. Epub 2018 Nov 27.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive Room 228 MSC 4320, Bethesda, MD, 20892, USA.

Fibrous dysplasia (FD) is a congenital disorder arising from sporadic mutation of the α-subunit of the Gs stimulatory protein. Osseous changes are characterised by the replacement and distortion of normal bone with poorly organised, structurally unsound, fibrous tissue. The disease process may be localised to a single or multiple bones. Read More

Am J Otolaryngol 2019 Mar - Apr;40(2):334-336. Epub 2018 Sep 18.

Department of Otolaryngology - Head & Neck Surgery, Emory University, Medical Office Tower (MOT), 9th Floor, 550 Peachtree Street NE, Atlanta, GA 30308, United States of America. Electronic address:

We present a rare case of a vascular anomaly of the sphenoid and temporal bones causing an expandable mass of the temporal region with dependent patient positioning and characteristic osseous changes on imaging. Initial diagnosis considerations included multiple myeloma (MM), fibrous dysplasia (FD), Paget's disease, lymphoma, meningoencephalocele (MEC), and vascular malformation (VaM). VaMs of the head and neck are rare and typically arise in the mandible and maxilla. Read More

Neuroimaging Clin N Am 2019 Feb 31;29(1):29-47. Epub 2018 Oct 31.

Department of Radiology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA; Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA. Electronic address:

Many bone dysplasias, some common and others rare, may involve the temporal bone causing conductive, sensorineural, or mixed hearing loss, vestibular dysfunction, or skull base foraminal narrowing, potentially affecting quality of life. Some conditions may affect only the temporal bone, whereas others may be more generalized, involving different regions of the body. High-resolution computed tomography may detect subtle osseous changes that can help define the type of dysplasia, and MR imaging can help define the degree of activity of lesions and potential associated complications. Read More

N Engl J Med 2018 11;379(20):1964-1965

National Institutes of Health, Bethesda, MD

Brain Tumor Res Treat 2018 Oct;6(2):86-91

Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.

Aneurysmal bone cyst (ABC) is a rare non-neoplastic bone lesion that involves mostly the long bones and vertebrae and may occur very rarely in the craniofacial bones. ABCs may occur as secondary bony pathologies in association with various benign and malignant bone tumors and with fibrous dysplasia (FD). FD is a common non-neoplastic bony pathology mostly affecting craniofacial bones. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(15):1188-1191

Department of Rhinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

To compare and analyze the incidence, clinical features ,imaging features, the preoperative serum alkalinosis phosphatase (ALP) and recurrence rates of osteoma, ossifying fibroma (OF), and fibrous dysplasia (FD) in sinus and maxillofacial benign fibrosis (FOLS). The 273 cases of FOLS with paranasal sinus and maxillofacial region in our hospital, among which there were 153 cases of osteoma, 44 cases of OF, and 76 cases of FD, were reviewed retrospectively and were follow-up for 6 months to 5 years. The incidence, gender, age, lesion location, preoperative serum ALP levels and recurrence rate of different lesions were analyzed and compared. Read More

World Neurosurg 2019 Jan 24;121:e246-e261. Epub 2018 Sep 24.

Department of Spine Pathology, N.N. Priorov Central Institute of Traumatology and Orthopedics, Moscow, Russia.

Introduction: With the introduction into the neurosurgical practice of minimally invasive methods using endoscopic techniques, it became possible to effectively remove hard-to-reach tumors, including central tumors of the anterior region of the posterior cranial fossa.

Objective: To analyze the results of surgical treatment of patients with various centrally located tumors of the base of the skull that extend into the anterior region of the posterior cranial fossa using the endoscopic endonasal transclival approach.

Methods: The personal surgical experience of the first author is 136 patients with various tumors (e. Read More

Acta Chir Orthop Traumatol Cech 2018 ;85(4):291-293

I. chirurgická klinika Lékařské fakulty Masarykovy Univerzity a Fakultní nemocnice U sv. Anny v Brně.

The purpose of the case report is to present the case of a 42-year-old woman with thoracic outlet syndrome caused by fibrous dysplasia of the first rib treated by surgical therapy through cervicothoracic approach by Grunenwald with complete vascular and partial brachial plexus preparation. Key words:thoracic outlet syndrome, fibrous dysplasia, cervicothoracic approach. Read More

Radiologia 2019 Mar - Apr;61(2):177-178. Epub 2018 Sep 17.

Hospital Universitario Virgen de las Nieves, Granada, España.

Cleft Palate Craniofac J 2018 Sep 10:1055665618798292. Epub 2018 Sep 10.

1 Department of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

Background: As 3-dimensional (3D) printers and models become more widely available and increasingly affordable, surgeons may consider investing in a printer for their own cleft or craniofacial center. To inform surgeons considering adoption of this evolving technology, this study describes one multi-surgeon center's 5-year experience using a 3D printer.

Methods: This study included 3D models printed between October 2012 and October 2017. Read More

Gen Dent 2018 Sep-Oct;66(5):77-78

Neuropathology 2018 Dec 6;38(6):624-630. Epub 2018 Sep 6.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

We report a case of a 20-month-old male presenting with seizures who was found to have a hyperintense lesion on T2-weighted images of magnetic resonance imaging in the left medial temporal lobe that was initially clinically and radiologically thought to be either low-grade glioma or focal cortical dysplasia. Histologic, immunohistochemical and molecular evaluation (array comparative genomic hybridization, Archer fusion panel) of the resection specimen demonstrated a highly infiltrative fibroblastic spindle cell neoplasm with mild nuclear atypia and an RBPMS-NTRK3 fusion. NTRK-fused mesenchymal tumors are known to involve extracranial sites but, to our knowledge, have not been described within the central nervous system. Read More

World Neurosurg 2018 Dec 31;120:159-162. Epub 2018 Aug 31.

Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Erasmus Medical Center and Sophia Children's Hospital, Rotterdam, The Netherlands.

Background: Fibrous dysplasia (FD) is most often a slowly progressive benign disease in which the normal bone structure is replaced by fibrous and osteoid tissue.

Case Description: A 16-year-old adolescent, known with FD in the sphenoid bone, suffered an acute decreased visual acuity with papilledema on the left eye. The radiologic images were best compatible with cystic degeneration of the known FD with optic nerve compression in the optic canal. Read More

Cureus 2018 Jun 29;10(6):e2894. Epub 2018 Jun 29.

Radiology, University of Miami, MIAMI, USA.

Laser thermal ablation is a novel minimally invasive neurosurgical technique that has proven to be beneficial in the treatment of a select group of neurosurgical conditions such as primary brain neoplasms, brain metastases, radiation necrosis, and epileptogenic lesions such as cortical dysplasia and mesial temporal sclerosis. The applicability of laser thermal ablation and its utility in the treatment of extra-axial (EA) brain neoplasms, mainly meningioma, is another novel use of this technique. Our article discusses the use and benefits of this technique in this particular clinical scenario. Read More

J Orthop Case Rep 2018 Mar-Apr;8(2):95-99

Department of Trauma, Hand and Reconstructive Surgery, Pelvic Center, University Hospital Hamburg Eppendorf, UKE.

Introduction: Fibrous dysplasia (FD) is an uncommon benign tumor of bone. Although FD can affect flat bones, it is rare for the scapula to be involved. In addition, little is known about the management of FD when it involves the scapula. Read More

J Med Case Rep 2018 Aug 31;12(1):240. Epub 2018 Aug 31.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Fibrous dysplasia is a rare benign, intramedullary, fibro-osseous lesion. It is thought to be a developmental disorder of bone maturation where normal lamellar bone is replaced by irregular trabecular bone ensnared with fibrous dysplastic tissue that is unable to complete maturation resulting in significant loss of mechanical strength. This, together with the inability to mineralize sufficiently, leads to deformity, pain, and pathological fractures. Read More

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Radiology, Princess Marina Hospital, Gaborone, Botswana.

McCune-Albright syndrome (MAS) is a rare disease characterised by triad of monostotic or polyostotic fibrous dysplasia, café au-lait skin spots and a variety of endocrine disorders; precocious puberty (PP) being the most common presenting symptom in female patients. Hyperfunction endocrinopathies including hyperthyroidism, growth hormone excess and cortisol excess are typical presentations in MAS. We present a case of 21-year-old woman with clinical and radiological characteristics of MAS triad; she presented with short stature which was attributed to both growth hormone deficiency and PP. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 07;32(7):893-898

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To evaluate the feasibility and effectiveness of proximal femoral nail anti-rotation (PFNA) combined with curettage and bone graft through Watson-Jones approach in the treatment of proximal femur benign tumors and tumor like lesions.

Methods: The clinical data of 38 patients with benign tumors and tumor like lesions in the proximal femur who were treated through the Watson-Jones approach with PFNA combined with curettage and bone graft between January 2008 and January 2015 were retrospective analysed. There were 24 males and 14 females with an average age of 28 years (range, 15-57 years). Read More

Exp Eye Res 2018 10 17;175:199-206. Epub 2018 Aug 17.

Eye Institute & Affiliated Xiamen Eye Center, Xiamen University Medical College, Xiamen, Fujian, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China. Electronic address:

Pterygium postoperative granuloma (PPG) is one of the common complications of pterygium surgery. In order to provide the structural features of PPG, and to further explore its pathogenetic mechanism, we analyzed clinical and pathological characteristics of 12 PPG cases. New blood vessels were observed under a slit lamp in PPG and peripheral conjunctival tissues. Read More

J Clin Endocrinol Metab 2018 Nov;103(11):4293-4303

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

Context: McCune-Albright syndrome (MAS) is a rare disorder characterized by fibrous dysplasia of bone, café-au-lait macules, and hyperfunctioning endocrinopathies. It arises from somatic gain-of-function mutations in GNAS, which encodes the cAMP-regulating protein Gαs. Somatic GNAS mutations have been reported in intraductal papillary mucinous neoplasms (IPMNs) and various gastrointestinal (GI) tumors. Read More

Dental Press J Orthod 2018 May-Jun;23(3):26-34

Universidade Estadual de Feira de Santana, Curso de Odontologia (Feira de Santana/BA, Brazil).

Florid cemento-osseous dysplasia is a sclerosing disease that affects the mandible, especially the alveolar process, and that is, in most cases, bilateral; however, in some cases it affects up to three or even four quadrants. During the disease, normal bone is replaced with a thinly formed, irregularly distributed tissue peppered with radiolucent areas of soft tissue. Newly formed bone does not seem to invade periodontal space, but, in several images, it is confused with the roots, without, however, compromising pulp vitality or tooth position in the dental arch. Read More

J Craniofac Surg 2018 Oct;29(7):1760-1766

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Craniofacial bone lesions involving the orbit are often associated with symptoms, including proptosis, orbital dystopia, and overall facial asymmetry. Fibrous dysplasia and osteoma are the 2 most commonly observed bone tumors in the craniofacial area. Nine patients with either craniofacial fibrous dysplasia or osteoma and an unacceptable aesthetic appearance were treated from January 2015 to July 2016. Read More

J Clin Imaging Sci 2018 18;8:23. Epub 2018 Jun 18.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Aim: The purpose of the study was to analyze and summarize the computed tomography (CT) and magnetic resonance imaging (MRI) findings of spinal monostotic fibrous dysplasia (MFD) as well as evaluate the clinical value of CT and MRI in MFD diagnosis.

Materials And Methods: CT ( = 4) and MRI ( = 5) images of six patients with pathologically confirmed spinal MFD were examined. The assessed image features included location, shape, rib involvement, vertebral collapse, margin, attenuation, and sclerotic rim on CT, as well as signal intensity, dark signal rim, and enhancement pattern on MRI. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 10;135(5):311-314. Epub 2018 Jul 10.

Head and Neck Department, Lariboisière Hospital, University Paris 7, 2, rue Amboise-Paré, 75010 Paris, France.

Objectives: Infratemporal fossa (ITF) tumors are rare and little is known about their general epidemiology, making it sometimes difficult for clinicians, who seldom encounter them, to distinguish between benign and malignant forms on the basis of the initial clinical and radiological work-up alone. The objectives of this retrospective study were: (i) to determine the respective prevalences of the various histologic types of ITF tumor, and (ii) to assess associations between certain clinical and radiological features and malignancy.

Methods: A single-center observational study in a university hospital included all new consecutive cases of ITF tumor treated from January 2000 to December 2016. Read More

Skeletal Radiol 2019 Jan 9;48(1):119-127. Epub 2018 Jul 9.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Objective: To examine the CT and MR imaging features of phosphaturic mesenchymal tumors (PMTs).

Materials And Methods: With IRB approval, our institutional radiology/pathology database was reviewed for pathologically-proven PMTs. CT and MRI examinations were reviewed in consensus noting several imaging features, and if available, comparative molecular imaging tests were analyzed. Read More

Korean J Fam Med 2019 Jan 6;40(1):58-60. Epub 2018 Jul 6.

Mealhada Primary Health Care Unit, Mealhada, Portugal.

Fibrous dysplasia (FD) is a non-malignant bone tumor that typically behaves as a slow and indolent growing mass lesion. We report the case of a female patient presenting with headache and facial deformity and later diagnosed with polyostotic fibrous dysplasia (PFD). A 29-year-old woman visited Mealhada Primary Health Care Unit complaining of headache, nasal congestion, and hyposmia for several weeks. Read More

Imaging Sci Dent 2018 Jun 19;48(2):131-137. Epub 2018 Jun 19.

Department of Oral and Maxillofacial Radiology, School of Dentistry, Chonbuk National University, Jeonju, Korea.

Cemento-osseous dysplasia (COD) is a benign fibro-osseous lesion of bone, in which normal bone is replaced by fibrous tissue, followed by calcification with osseous and cementum-like tissue. COD is classified into 3 categories according to its location: periapical, focal, and florid COD (FCOD). On radiography, FCOD appears radiolucent in its early stages. Read More

J Coll Physicians Surg Pak 2018 Jun;28(6):S72-S74

Department of Radiology, Armed Forces Institute of Radiology and Imaging (AFIRI), Rawalpindi.

Fibrous dysplasia is a slow growing fibro-osseous tumor, which is infrequent in craniofacial location and very rarely found in paranasal sinuses. Its occurrence is usually in children and young adolescents. The complications common in this location are related to the sinus ostia obstruction, like sinusitis or mucocele formation. Read More

Clin Nucl Med 2018 Aug;43(8):625-626

Mazabraud's, a syndrome consisting of fibrous dysplasia and soft tissue myxomas, is a rare disorder with less than 100 cases reported in the literature. Appearance of lesions in Mazabraud's syndrome on FDG PET/CT scan in an oncological scenario can be misinterpreted as malignancy. We present the case of a 69-year-old woman, diagnosed with metastatic colon carcinoma and suspected osseous as well as soft tissue metastases, who was later found to have concomitant Mazabraud's syndrome. Read More

Skeletal Radiol 2019 Jan 27;48(1):151-157. Epub 2018 May 27.

Department of Radiology, The Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, UK.

Mazabraud's syndrome is a rare disorder characterised by the association of fibrous dysplasia with intramuscular myxomas. We present a 36-year-old woman with right anterior knee pain and a buttock mass. Imaging showed aggressive bone destruction within an area of fibrous dysplasia in the right femur and a mass with myxoid signal characteristics in the right adductor region. Read More

Rev Neurol 2018 Jun;66(11):373-376

Universidad de Antioquia, Medellin, Colombia.

Introduction: «Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinical features of a patient with giant cell arteritis. Read More

Skeletal Radiol 2018 Nov 23;47(11):1571-1576. Epub 2018 May 23.

Medical Oncology "A", IFO-Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

Fibrous dysplasia (FD) is a benign fibro-osseous disease of the bone that may be solitary or multicentric. It is important to distinguish this type of lesion from low-grade osteosarcomas (LGOS) and from secondary sarcomas, because malignant transformation has rarely been reported. It is classically described as having a ground-glass appearance, endosteal scalloping, and thinning of the cortex. Read More

Insights Imaging 2018 Aug 15;9(4):571-589. Epub 2018 May 15.

Division of Radiology, Department of Imaging and Medical Informatics, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland.

Although rare, masses and mass-like lesions of developmental and genetic origin may affect the paediatric craniofacial skeleton. They represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation and disfigurement. The most common lesions include fibrous dysplasia, dermoid cysts, vascular malformations and plexiform neurofibromas. Read More

J Surg Oncol 2018 Jun 3;117(8):1786-1798. Epub 2018 May 3.

Queen Elizabeth II Health Sciences Center, Halifax Infirmary, Dalhousie University, Halifax, Nova Scotia, Canada.

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. Read More

Indian J Radiol Imaging 2018 Jan-Mar;28(1):111-114

Department of Radiology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

A 12-year-old female presented with complaints of progressive visual impairment in both her eyes. On clinical examination, she was short for her age and her ophthalmoscopic examination revealed bilateral optic atrophy. Computed tomography of the patient revealed multiple expansile lytic lesions of mandible suggesting cherubism. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Apr;53(4):280-283

Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou Jiangsu 215006, China.

Florid cemento-osseous dysplasia (FLCOD) is a rare, extensive bone metabolism disorder, which occurs only in the jaw bone. It is usually asymptomatic for a long time and discovered incidentally during a radiological examination. The characteristics of FLCOD in the initial stages are similar to those of periapical granuloma or jaw cyst, which may lead to misdiagnosis. Read More

J Bone Miner Res 2018 Sep 22;33(9):1641-1648. Epub 2018 May 22.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.

Scoliosis is a complication of fibrous dysplasia/McCune-Albright syndrome (FD/MAS); however, risk factors and long-term outcomes are unknown. Bisphosphonates are commonly used; however, it is unknown whether their use decrease the risk of progressive scoliosis. Clinical data from the National Institutes of Health (NIH) cohort study was reviewed. Read More

Clin Cardiol 2018 Mar 25;41(3):300-306. Epub 2018 Mar 25.

Service Rythmologie, Hôpital Cardiologique Louis Pradel, Hospices Civils de Lyon, Lyon, France.

Arrhythmogenic right ventricular dysplasia (ARVD) is a rare cardiomyopathy characterized by the progressive replacement of cardiomyocytes by fatty and fibrous tissue in the right ventricle (RV). These infiltrations lead to cardiac electrical instability and ventricular arrhythmia. Current treatment for ARVD is empirical and essentially based on treatment of arrhythmia. Read More